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Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and memory deficits in a rodent model of cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Delayed inhibition of the Ca2+-permeable TRPM2 ion channel restored LTP post-CA/CPR, yet the mechanisms upstream of TRPM2 activation remain elusive. This study investigates CD38 as a potential regulator of TRPM2, highlighting a novel target to reverse hippocampal synaptic plasticity deficits after ischemia. We observe elevated levels of CD38 in activated astrocytes in the CA1 region of the hippocampus 7 days following CA/CPR in both male and female mice. Delayed inhibition of CD38 reverses hippocampal synaptic plasticity impairments at subacute timepoints after CA/CPR, phenocopying TRPM2 restoration of LTP. Our previous findings demonstrated that TRPM2 inhibition reverses the CA/CPR-induced enhancement of GABAA receptor (GABAAR) clustering, which contribute to ongoing LTP deficits. We, therefore, assessed the effect of CD38 on GABAergic inhibitory potentiation and find that inhibition of CD38 reverses GABAAR clustering in a TRPM2-dependent manner. In this study, we identify astroglial CD38 as a potential target and upstream regulator of the TRPM2 channel, offering a promising approach to restore hippocampal synaptic plasticity impairments following GCI through modulation of GABAergic signaling.

BackgroundPatient-reported outcome and experience measures can play a critical role in providing patient-centered and value-based health care to a growing population of patients who are chronically ill. Value-based telemedicine platforms such as the Naveta initiative may facilitate the effective integration of these tools into health care systems. ObjectiveThis study aims to evaluate the response rate to electronic patient-reported outcome measures (ePROMs) and electronic patient-reported experience measures (ePREMs) among patients participating in the Naveta telemedicine initiative and its correlations with sociodemographic and clinical characteristics, as well as the evolution of the response rates over time. MethodsBetween January 1, 2021, and June 30, 2023, a total of 53,364 ePREMs and ePROMs for 20 chronic conditions were administered through the Naveta-Phemium platform. Descriptive statistics were used to summarize continuous and categorical variables. Differences in response rates within each sociodemographic variable were analyzed using logistic regression models, with significance assessed via chi-square and post hoc Tukey tests. Two-way ANOVA was used to examine the interaction between time interval and disease type on response rate evolution. ResultsA total of 3372 patients with severe chronic diseases from 64 public hospitals in Spain participated in the Naveta health questionnaire project. The overall response rate to ePROMs and ePREMs during the first 2.5 years of the Naveta initiative was 46.12% (24,704/53,364), with a baseline rate of 53.33% (7198/13,496). Several sociodemographic factors correlated with lower response rates, including male gender, older age, lower education level, frequent alcohol use, being a student, and not being physically active. There were also significant variations in response rates among different types of chronic conditions (P

Objective: This study aimed to use the Person-Centered Coordinated Care Experience Questionnaire (P3CEQ) to assess the experience of person-centered coordinated care among people with long-term conditions in the Balearic Islands, Spain. Methods: Over 1300 participants receiving treatment for chronic conditions or HIV pre-exposure prophylaxis were invited to complete the P3CEQ and a socio-demographic questionnaire, both administered electronically via the Naveta app. The P3CEQ assesses the key domains of the P3C through an 11-item questionnaire. Items 1, 2, 3, 4, 5, 8, 9 and 10 assess specifically person-centredness (PC subscale), while items 5, 6, 7, 8 and 9 measure care coordination (CC subscale; question 7 includes 4 sub-questions to specifically assess care plans). Descriptive statistics were used to summarize patient characteristics and P3CEQ items scores. Data analysis included chi-squared test of independence, Student’s t -test and analysis of variance test. Pairwise comparisons were adjusted by Bonferroni correction. Results: The P3CEQ and a socio-demographic questionnaire were sent to 1313 individuals (651 men, 657 women, 5 ‘other gender’). A response rate of 35.34% was achieved, with 464 P3CEQ responders (223 men and 241 women). Significant differences in response rates were observed by age, smoking status, alcohol consumption, membership of patient organizations, and use of alternative medicine. Care planning was rated significantly lower than other measured domains. Women experienced less person-centered care than men (16.64 vs 17.91) and rated care coordination worse than their male counterparts (9.18 vs 10.23). There were also differences in scores between medical condition types, with cancer and inflammatory bowel disease patients rating highest for both person-centered care (21.20 and 19.13, respectively) and care coordination (10.70 vs 10.88, respectively). Patients with skin and rheumatic diseases rated lowest their experience of person-centered care. People with higher education and those employed or studying experienced better person-centeredness. Conclusion: Using the P3CEQ, we detected significant differences in the care experiences of people with chronic conditions, suggesting the need to address potential gender biases, social inequalities, and the poorer ratings observed for certain conditions in the study population.

Wave setup is a physical process that induces a temporal increase of the mean water level due to wave dissipation by bottom friction and breaking in the surf zone, extending over tens to hundreds of meters in the cross-shore direction. Wave setup contribution to coastal sea level solely induced by wind and atmospheric effects can increase by more than 100% under extreme events and conditions favoring its formation. It is therefore crucial to consider this phenomenon when assessing sea-level-related coastal hazards. Previous studies estimated the wave setup effect by means of numerical modeling and empirical formulations at regional and global scale. Such analyses require either high computational capacity to implement high-resolution numerical models over large domains, and/or accurate information on coastal morphological features from global or regional databases. Although the Mediterranean Sea is a fetch-limited environment, waves generated from extra-tropical cyclones are powerful enough for wave setup to develop, and subsequently for a potential significant wave setup contribution to extreme coastal sea level. Through the use of both numerical and empirical methods, we investigate the uncertainty associated to wave setup representation on the frequency and magnitude of coastal extreme sea levels occurring on sandy beaches in the Mediterranean Sea. Wave setup values are compared at beach scale between process-based modeling and empirical approaches, showing highly variable results. We also quantify the impact of wave setup on return levels of coastal sea level extremes using reconstructed sea levels. We employ various methods to calculate the wave setup component. Results show high spatial dispersion, with clear differences between the numerical and empirical approaches, especially in regions prone to the development of energetic waves. The total inter-method dispersion of 100-year return levels is often higher than 30 cm for average values of 62.4 cm. We emphasize the important limitations related to wave setup modeling (i.e., its underestimation) at large scale, and call for caution when applying empirical formulations (generally developed from local studies) at regional to global scale, which can lead to unrealistic wave setup values.

Abstract Ecosystems threatened by climate change can boost their resilience by developing spatial patterns. Spatially regular patterns in wave-exposed seagrass meadows are attributed to self-organization, yet underlying mechanisms are not well understood. Here, we show that these patterns could emerge from feedbacks between wave reflection and seagrass-induced bedform growth. We derive a theoretical model for surface waves propagating over a growing seagrass bed. Wave-induced bed shear stress shapes bedforms which, in turn, trigger wave reflection. Numerical simulations show seagrass pattern development once wave forcing exceeds a critical amplitude. In line with Mediterranean Sea field observations, these patterns have half the wavelength of the forcing waves. Our results raise the hypothesis that pattern formation optimizes the potential of seagrass meadows to reflect wave energy, and a clear direction for future field campaigns. If wave-reflecting pattern formation increases ecosystem resilience under globally intensifying wave climates, these ecosystems may inspire nature-based coastal protection measures.

Climate change is causing problems for agriculture, but the effect of combined abiotic stresses on crop nutritional quality is not clear. Here we studied the effect of 10 combinations of climatic conditions (temperature, CO2, O3 and drought) under controlled growth chamber conditions on the grain yield, protein, and mineral content of 3 wheat varieties. Results show that wheat plants under O3 exposure alone concentrated + 15 to + 31% more grain N, Fe, Mg, Mn P and Zn, reduced K by - 5%, and C did not change. Ozone in the presence of elevated CO2 and higher temperature enhanced the content of Fe, Mn, P and Zn by 2-18%. Water-limited chronic O3 exposure resulted in + 9 to + 46% higher concentrations of all the minerals, except K. The effect of climate abiotic factors could increase the ability of wheat to meet adult daily dietary requirements by + 6% to + 12% for protein, Zn and Fe, but decrease those of Mg, Mn and P by - 3% to - 6%, and K by - 62%. The role of wheat in future nutrition security is discussed.

Acute exercise induces transient modifications in the tumor microenvironment and has been linked to reduced tumor growth along with increased infiltration of immune cells within the tumor in mouse models. In this study, we aimed to evaluate the impact of acute exercise before treatment administration on tumor growth in a mice model of MC38 colorectal cancer receiving an immune checkpoint inhibitor (ICI) and chemotherapy. Six-week-old mice injected with colorectal cancer cells (MC38) were randomized in 4 groups: control (CTRL), immuno-chemotherapy (TRT), exercise (EXE) and combined intervention (TRT/EXE). Both TRT and TRT-EXE received ICI: anti-PD1-1 (1 injection/week) and capecitabine + oxaliplatin (5 times a week) for 1 week (experimentation 1), 3 weeks (experimentation 2). TRT-EXE and EXE groups were submitted to 50 minutes of treadmill exercise before each treatment administration. Over the protocol duration, tumor size has been monitored daily. Tumor growth and microenvironment parameters were measured after the intervention on Day 7 (D7) and Day 16 (D16). From day 4 to day 7, tumor volumes decreased in the EXE/TRT group while remaining stable in the TRT group (p=0.0213). From day 7 until day 16 tumor volume decreased with no significant difference between TRT and TRT/EXE. At D7 the TRT/EXE group exhibited a higher total infiltrate T cell (p=0.0118) and CD8+ cytotoxic T cell (p=0.0031). At D16, tumor marker of apoptosis, vascular integrity and inflammation were not significantly different between TRT and TRT/EXE. Our main result was that acute exercise before immuno-chemotherapy administration significantly decreased early-phase tumor growth (D0 to D4). Additionally, exercise led to immune cell infiltration changes during the first week after exercise, while no significant molecular alterations in the tumor were observed 3 weeks after exercise.

Robotics and autonomous systems are reshaping the world, changing healthcare, food production and biodiversity management. While they will play a fundamental role in delivering the UN Sustainable Development Goals, associated opportunities and threats are yet to be considered systematically. We report on a horizon scan evaluating robotics and autonomous systems impact on all Sustainable Development Goals, involving 102 experts from around the world. Robotics and autonomous systems are likely to transform how the Sustainable Development Goals are achieved, through replacing and supporting human activities, fostering innovation, enhancing remote access and improving monitoring. Emerging threats relate to reinforcing inequalities, exacerbating environmental change, diverting resources from tried-and-tested solutions and reducing freedom and privacy through inadequate governance. Although predicting future impacts of robotics and autonomous systems on the Sustainable Development Goals is difficult, thoroughly examining technological developments early is essential to prevent unintended detrimental consequences. Additionally, robotics and autonomous systems should be considered explicitly when developing future iterations of the Sustainable Development Goals to avoid reversing progress or exacerbating inequalities.

Abstract Shoreline position is a key parameter of a beach state, often used as a descriptor of the response of the system to changes in external forcing, such as sea-level rise. Changes in shoreline position are the result of coupled hydrodynamic and morphodynamic processes happening in the nearshore and acting at different temporal scales. Due to this complexity, methodologies aimed at reproducing shoreline evolution at decadal time scale require many simplifications. Simpler methods usually consider an equilibrium beach profile whose shape depends only on beach morphology, and whose location varies depending on incoming forcing. Here, we derive a general equation for shoreline evolution using equilibrium beach profiles. We particularize it based on several common assumptions, and evaluate changes on shoreline position caused by sea-level rise, combined with simultaneous wave and high-frequency sea-level forcing. We compare our model against other analytical equilibrium beach profile-based models and with a dynamic model explicitly computing sediment transport. Results indicate that: (i) it is necessary to consider the area of the emerged beach subject to marine forcing rather than focusing only on the submerged part, (ii) the rates of shoreline recession may change for narrow beaches, defined as those for which marine forcings act onto all of their aerial surface, and (iii) Bruun’s Rule can describe beach shoreline evolution, but the uncertainty in selecting the landward boundary of the active profile entails a huge uncertainty in the magnitude of shoreline evolution. This problematic uncertainty can be drastically reduced if instantaneous forcing conditions are used instead of the arbitrary emerged/submerged active profile boundaries typically defined by only one statistic parameter of extreme conditions.

Desde el 2019, el colectivo académico AnimationDuo organiza talleres (Animation-Making Workshops) dirigidos a grupos en situación de vulnerabilidad, que combinan el servicio a la comunidad con un proyecto de investigación que estudia las cualidades y competencias del proceso de animación stop-motion. El programa consiste en experiencias prácticas estructuradas a partir de la teoría de la ética del cuidado y aspectos puntuales de las reflexiones de Martin Heidegger sobre la materia, las cosas, y los objetos (utensilios). El ensayo argumenta que, al fomentar un modo de relación con el mundo más-que-humano que enfatiza la importancia del tacto, el proceso de animación stop-motion estimula formas alternativas de entender el mundo material y sus interacciones con ser humano que tienen el potencial de mejorar el bienestar de sus creadores.

In the Panama Bight, two different seasonal surface circulation patterns coincide with a strong mean sea level variation, as observed from 27 years of absolute dynamic topography (ADT) and the use of self-organizing maps. From January to April, a cyclonic gyre with a strong southwestward Panama Jet Surface Current (PJSC) dominates the basin circulation, forced by the Panama surface wind jet that also produces upwelling, reducing sea surface temperature (SST), increasing sea surface salinity (SSS) and causing an ADT decrease. From June to December, the Choco surface wind jet enhances SST, precipitation and river runoff, which reduces SSS, causing an ADT rise, which in turn forces a weak circulation in the bight, vanishing the PJSC. Interannual variability in the region is strongly affected by El Niño–Southern Oscillation (ENSO); however this climatic variability does not modify the seasonal circulation patterns in the Panama Bight. In contrast, the positive (negative) ENSO phase increases (decreases) SST and ADT in the Panama Bight, with a mean annual difference of 0.9 ∘C and 9.6 cm, respectively, between the two conditions, while its effect on SSS is small. However, as the strong seasonal SST, SSS and ADT ranges are up to 2.2 ∘C, 2.59 g kg−1 and 28.3 cm, the seasonal signal dominates over interannual variations in the bight.

Abstract Systematic and sustained high quality measurements of nearshore waves and beach morphology are crucial to understand morphodynamic processes that determine beach evolution, to unravel the effects of global warming on sandy coasts and thus improve forecasting models. In 2011 a comprehensive beach monitoring program, the first in the Mediterranean Sea, started at Cala Millor Beach on the island of Mallorca (Spain). The aim was to provide long-term datasets of near-shore morphodynamics in a carbonate sandy micro-tidal and semi-embayed beach fronted by a Posidonia oceanica seagrass meadow. We present our morphological and hydrodynamical dataset of Cala Millor covering more than a decade. The dataset includes topobathymetries, shoreline positions obtained from video cameras, meteorological parameters from a weather station, currents, as well as waves and sea level from ADCP measurements and sediment size. This free and unrestricted archived dataset can be used to support the modelling of erosion-deposition patterns, calibrate beach evolution models, and as a result to propose adaptation and mitigation actions under different global change scenarios.

Introducción: El tema del cambio climático y sus efectos, en la salud, educación y transporte, es un tema emergente, que pretende la optimización del consumo y la eficiencia energética. Esta investigación se plantea como objetivo, la caracterización del uso y aprovechamiento de energías, en establecimientos de atención médica de la región capital durante el año 2022, considerando la distribución energética, eficiencia y fuentes primarias de energía utilizadas en este país. Métodos: Se trata de una investigación descriptiva, transversal y prospectiva, a través del análisis cuali-cuantitativo, con el uso de informantes clave quienes consideran importante la iluminación natural en los espacios y el mayor aprovechamiento energético en áreas como la quirúrgica y consulta externa. Resultados: Surge el uso de la energía solar, eólica e hidráulica como recursos energéticos aprovechables, así como la sostenibilidad y la mantenibilidad en el diseño y rediseño de infraestructuras hospitalarias. Los tipos de energías utilizados en Venezuela, siguen correspondiendo a la hidráulica y combustibles fósiles, se conoce la tecnología e implementación de paneles solares para la mejoría del cambio climático, la huella del carbono, el uso de energías verdes y reducción de combustibles fósiles. Su aceptación depende de regulaciones y la concientización energética como elementos fundamentales para el cambio.

The extreme wave height distribution in the Caribbean Sea is studied using a new method based on the maximum basin-wide aggregate of significant wave height, Hs, values per month. Besides, by means of the Self-Organizing Maps (SOM) technique, we identify coherent geographical regions with similar extreme wave height variability in the Caribbean Sea. Our findings revealed three primary regions: the eastern side with comparatively lower values, the central region with intermediate values, and the western side with the highest extreme wave heights. The study also examines the wind forcing conditions driving the spatial and temporal variability of the extreme waves, highlighting the influence of the low-pressure belt dynamics as well as the role played by the Caribbean Low-Level Jet (CLLJ) index, and the impact of cold fronts and hurricanes on extreme wave heights. Additionally, we explore the relationship between the extreme wave height distribution and climatic indices, such as the Atlantic Multidecadal Oscillation (AMO), the Atlantic Meridional Mode (AMM), the North Atlantic Oscillation (NAO) and the Oceanic Niño (ONI). The results reveal that the spatial distribution of extreme wave heights in the Caribbean Sea is mostly ruled by the influence of the CLLJ, with correlations close to 80%. In addition, significant correlations were observed between the extreme wave heights and the ENSO in the central Caribbean, as well as positive correlations between the extreme wave heights and NAO in the eastern part of the basin, and significant values of correlation with the negative phases of AMO and AMM in the whole basin. We show that, unlike conventional (or broadly used) methods deployed to identify extreme wave height, such as percentile 99th, Hs99, our methodology allows a further assessment of the wind and climate forcing conditions associated with the extreme wave events. Although, we acknowledge that the method here presented has limitations to capture extreme wave height outliers, it has the advantage of being used concomitant with the wind forcing to develop multivariate wave climate analysis at basin scale, and could be extended to a more local scale when studying coastal processes.

La Fundación Palarq, entidad privada y sin ánimo de lucro, fue creada en 2016. Desde esa fecha, apoya a proyectos de investigación en Arqueología y Paleontología Humana, con tres convocatorias; una anual, dirigida a equipos españoles que pertenecen a entidades públicas españolas, que desarrollen su actividad en el extranjero, excluyendo Europa. Una segunda, de carácter bienal, corresponde a los Premios Nacionales de Arqueología y Paleontología Humana, abierto a proyectos tanto en España como en el extranjero. La tercera línea de apoyo a la investigación está destinada a subvencionar actividades incluidas dentro de la llamada arqueometría, en proyectos dirigidos por equipos españoles que, en este caso, también trabajen en territorio nacional. Otra de las actividades a las que se dedica esta fundación es la difusión de conocimiento en paleontología humana y arqueología en general. En este caso está relacionada con dar a conocer los resultados de los proyectos que apoya y, por otra parte, dar a conocer de forma rigurosa pero amena estas disciplinas en general. En ambos casos colaborando con los medios de comunicación, y con el uso de las actuales redes sociales, en especial YouTube y Tik Tok. Otras de las actividades a las que se dedica esta Fundación es la difusión de conocimiento en paleontología humana y arqueología en general. En este caso relacionada con dar a conocer los resultados de los proyectos que apoya y, por otra parte, dar a conocer de forma rigurosa pero amena estas disciplinas en general. En ambos casos colaborando con los medios de comunicación, y con el uso de las actuales redes sociales, en especial en YouTube y Tik Tok.

Every year the Caribbean Sea faces the passage of several tropical cyclones that generate coastal extreme sea levels with potential strong and hazardous impacts. In this work we simulate the storm surges and wind waves induced by a set of 1000 tropical cyclones over the Caribbean Sea that are representative of the present-day climate. These events have been extracted from a global database of synthetic tropical cyclones spanning a 10 000-year period. The atmospheric forcing fields, associated with the set of tropical cyclones, are used to feed a coupled hydrodynamic–wave model with high resolution (∼ 2 km) along the continental and island coasts. Given the large number of events modelled, our results allow detailed statistical analyses of the magnitude and mechanisms of coastal extreme sea levels, as well as the identification of one of the most exposed areas to both storm surges and extreme wind waves.

Abstract Diatoms are among the most efficient autotrophic organisms for oceanic primary production and carbon sequestration. Yet, the spatial distributions of these planktonic organisms remain puzzling and the underlying physical processes poorly known, especially in oligotrophic open waters. Here we investigate what dynamical conditions are conducive to episodic diatom blooms in oceanic deserts based on Lagrangian diagnosis and satellite‐derived phytoplankton functional types and currents. The coherence of the flow is diagnosed in space and time simultaneously through the Lagrangian coherence rate (LCR) to identify which dynamical structures favor diatom growth. Observations evidence that flow structures with high LCR (40 days or longer) in areas with elevated eddy kinetic energy and vorticity sustain high diatom concentrations in the sunlit layers. Our findings show that the integration of Eulerian kinematic variables into a Lagrangian frame reveals new dynamical aspects of geophysical turbulence and unveil their biological impacts.

Resumen: Objetivo: Conocer la valoración y preferencias de usuarios y profesionales sanitarios sobre la teleconsulta en Atención Primaria. Diseño: Estudio transversal mediante encuesta, telefónica a usuarios y presencial a profesionales, en 2021. Emplazamiento: Atención Primara urbana. Sujetos: Muestra aleatoria de usuarios con teleconsultas en el último año, estratificados por sexo y edad, y médicos y enfermeros de los centros participantes. Mediciones: Variables Likert valorando la teleconsulta según motivos de consulta, preferencias y aspectos relacionados. Análisis descriptivo y comparación de proporciones y medias. Resultados: Responden 300 pacientes y 48 profesionales. Ambos valoran positivamente la teleconsulta para gestionar la receta electrónica (RE) (el 83 y el 83%, respectivamente), la incapacidad temporal (IT) (el 80 y el 64%) y cuestiones relacionadas con la COVID-19 (el 71 y el 58%). La valoración positiva de la teleconsulta disminuye para el tratamiento de las enfermedades agudas (el 47 y el 25%) y crónicas (el 49 y el 33%). Globalmente las personas