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1. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Author

Dellon, Evan S., Gonsalves, Nirmala, Abonia, J. Pablo, Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Attwood, Stephen E., Auth, Marcus K.H., Bailey, Dominique D., Biederman, Luc, Blanchard, Carine, Bonis, Peter A., Bose, Paroma, Bredenoord, Albert J., Chang, Joy W., Chehade, Mirna, Collins, Margaret H., Di Lorenzo, Carlo, Dias, Jorge Amil, Dohil, Ranjan, Dupont, Christophe, Falk, Gary W., Ferreira, Cristina T., Fox, Adam T., Genta, Robert M., Greuter, Thomas, Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Horsley-Silva, Jennifer L., Ishihara, Shunji, Ishimura, Norihisa, Jensen, Elizabeth T., Gutiérrez-Junquera, Carolina, Katzka, David A., Khoury, Paneez, Kinoshita, Yoshikazu, Kliewer, Kara L., Koletzko, Sibylle, Leung, John, Liacouras, Chris A., Lucendo, Alfredo J., Martin, Lisa J., McGowan, Emily C., Menard-Katcher, Calies, Metz, David C., Miller, Talya L., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Murch, Simon, Nhu, Quan M., Nomura, Ichiro, Nurko, Samuel, Ohtsuka, Yoshikazu, Oliva, Salvatore, Orel, Rok, Papadopoulou, Alexandra, Patel, Dhyanesh A., Pesek, Robert D., Peterson, Kathryn A., Philpott, Hamish, Putnam, Philip E., Richter, Joel E., Rosen, Rachel, Ruffner, Melanie A., Safroneeva, Ekaterina, Schreiner, Philipp, Schoepfer, Alain, Schroeder, Shauna R., Shah, Neil, Souza, Rhonda F., Spechler, Stuart J., Spergel, Jonathan M., Straumann, Alex, Talley, Nicholas J., Thapar, Nikhil, Vandenplas, Yvan, Venkatesh, Rajitha D., Vieira, Mario C., von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Wershil, Barry K., Wright, Benjamin L., Yamada, Yoshiyuki, Yang, Guang-Yu, Zevit, Noam, Rothenberg, Marc E., Furuta, Glenn T., and Aceves, Seema S.

Published
2022
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2. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.

Author

Dellon, Evan, Liacouras, Chris, Molina-Infante, Javier, Furuta, Glenn, Spergel, Jonathan, Zevit, Noam, Spechler, Stuart, Attwood, Stephen, Straumann, Alex, Alexander, Jeffrey, Atkins, Dan, Arva, Nicoleta, Blanchard, Carine, Bonis, Peter, Book, Wendy, Capocelli, Kelley, Chehade, Mirna, Cheng, Edaire, Collins, Margaret, Davis, Carla, Dias, Jorge, Di Lorenzo, Carlo, Dohil, Ranjan, Dupont, Christophe, Falk, Gary, Ferreira, Cristina, Fox, Adam, Gonsalves, Nirmala, Gupta, Sandeep, Katzka, David, Kinoshita, Yoshikazu, Menard-Katcher, Calies, Kodroff, Ellyn, Metz, David, Miehlke, Stephan, Muir, Amanda, Mukkada, Vincent, Murch, Simon, Nurko, Samuel, Ohtsuka, Yoshikazu, Orel, Rok, Papadopoulou, Alexandra, Peterson, Kathryn, Philpott, Hamish, Putnam, Philip, Richter, Joel, Rosen, Rachel, Rothenberg, Marc, Schoepfer, Alain, Scott, Melissa, Shah, Neil, Sheikh, Javed, Souza, Rhonda, Strobel, Mary, Talley, Nicholas, Vaezi, Michael, Vandenplas, Yvan, Vieira, Mario, Walker, Marjorie, Wechsler, Joshua, Wershil, Barry, Wen, Ting, Yang, Guang-Yu, Hirano, Ikuo, Bredenoord, Albert, and Aceves, Seema

Subjects
Diagnosis, Eosinophilic Esophagitis, Esophageal Eosinophilia, Proton Pump Inhibitor, Algorithms, Consensus, Diagnostic Techniques, Digestive System, Eosinophilic Esophagitis, Gastroenterology, Humans, Predictive Value of Tests, Prognosis, Proton Pump Inhibitors
Abstract

BACKGROUND & AIMS: Over the last decade, clinical experiences and research studies raised concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for eosinophilic esophagitis (EoE). We aimed to clarify the use of PPIs in the evaluation and treatment of children and adults with suspected EoE to develop updated international consensus criteria for EoE diagnosis. METHODS: A consensus conference was convened to address the issue of PPI use for esophageal eosinophilia using a process consistent with standards described in the Appraisal of Guidelines for Research and Evaluation II. Pediatric and adult physicians and researchers from gastroenterology, allergy, and pathology subspecialties representing 14 countries used online communications, teleconferences, and a face-to-face meeting to review the literature and clinical experiences. RESULTS: Substantial evidence documented that PPIs reduce esophageal eosinophilia in children, adolescents, and adults, with several mechanisms potentially explaining the treatment effect. Based on these findings, an updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement. CONCLUSIONS: EoE should be diagnosed when there are symptoms of esophageal dysfunction and at least 15 eosinophils per high-power field (or approximately 60 eosinophils per mm2) on esophageal biopsy and after a comprehensive assessment of non-EoE disorders that could cause or potentially contribute to esophageal eosinophilia. The evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EoE than as a diagnostic criterion, and we have developed updated consensus criteria for EoE that reflect this change.

Published
2018

3. Synbiotics in the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications

Author

Hojsak, Iva, Kolaček, Sanja, Mihatsch, Walter, Mosca, Alexis, Shamir, Raanan, Szajewska, Hania, Vandenplas, Yvan, van den Akker, Chris H. P., Berni Canani, Roberto, Dinleyici, Ener Cagri, Domellof, Magnus, van Goudoever, Johannes B., Guarino, Alfredo, Gutierrez-Castrellon, Pedro, Indrio, Flavia, Orel, Rok, Salvatore, Silvia, and Weizman, Zvi

Published
2023
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4. Reevaluating the FDA's warning against the use of probiotics in preterm neonates : a societal statement by ESPGHAN and EFCNI

Author

van den Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez-Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, van Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, Szajewska, Hania, van den Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez-Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, van Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, and Szajewska, Hania

Abstract

The recent advisory issued by the United States Food and Drug Administration, cautioning against the routine administration of probiotics in preterm neonates, has sparked a lively debate within the scientific community. This commentary presents a perspective from members of the Special Interest Group on Gut Microbiota and Modifications within the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and other authors who contributed to the ESPGHAN position paper on probiotics for preterm infants, as well as representatives from the European Foundation for the Care of Newborn Infants. We advocate for a more nuanced and supportive approach to the use of certain probiotics in this vulnerable population, balancing the demonstrated benefits and risks.

Published
2024
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6. Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).

Author

Amil‐Dias, Jorge, Oliva, Salvatore, Papadopoulou, Alexandra, Thomson, Mike, Gutiérrez‐Junquera, Carolina, Kalach, Nicolas, Orel, Rok, Auth, Marcus Karl‐Heinz, Nijenhuis‐Hendriks, Danielle, Strisciuglio, Caterina, Bauraind, Olivia, Chong, Sonny, Ortega, Gloria Dominguez, Férnandez, Sonia Férnandez, Furman, Mark, Garcia‐Puig, Roger, Gottrand, Frederic, Homan, Matjaz, Huysentruyt, Koen, and Kostovski, Aco

Published
2024
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7. Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications

Author

Indrio, Flavia, primary, Dinleyici, Ener Cagri, additional, Berni Canani, Roberto, additional, Domellöf, Magnus, additional, Francavilla, Ruggiero, additional, Guarino, Alfredo, additional, Gutierrez Castrellon, Pedro, additional, Orel, Rok, additional, Salvatore, Silvia, additional, Van den Akker, Chris H. P., additional, and Weizman, Zvi, additional

Published
2024
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8. Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis

Author

Papadopoulou, Alexandra, primary, Amil‐Dias, Jorge, additional, Auth, Marcus Karl‐Heinz, additional, Chehade, Mirna, additional, Collins, Margaret H., additional, Gupta, Sandeep K., additional, Gutiérrez‐Junquera, Carolina, additional, Orel, Rok, additional, Vieira, Mario C., additional, Zevit, Noam, additional, Atkins, Dan, additional, Bredenoord, Albert J., additional, Carneiro, Fatima, additional, Dellon, Evan S., additional, Gonsalves, Nirmala, additional, Menard‐Katcher, Calies, additional, Koletzko, Sibylle, additional, Liacouras, Chris, additional, Marderfeld, Luba, additional, Oliva, Salvatore, additional, Ohtsuka, Yoshikazu, additional, Rothenberg, Marc E., additional, Strauman, Alex, additional, Thapar, Nikhil, additional, Yang, Guan‐Yu, additional, and Furuta, Glenn T., additional

Published
2024
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9. Training in Paediatric Clinical Nutrition Across Europe: A Survey of the National Societies Network (2016–2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, and Koletzko, Berthold

Published
2022
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13. Reevaluating the FDA's warning against the use of probiotics in preterm neonates: A societal statement by ESPGHAN and EFCNI

Author

Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez‐Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, and Szajewska, Hania

Abstract

The recent advisory issued by the United States Food and Drug Administration, cautioning against the routine administration of probiotics in preterm neonates, has sparked a lively debate within the scientific community. This commentary presents a perspective from members of the Special Interest Group on Gut Microbiota and Modifications within the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and other authors who contributed to the ESPGHAN position paper on probiotics for preterm infants, as well as representatives from the European Foundation for the Care of Newborn Infants. We advocate for a more nuanced and supportive approach to the use of certain probiotics in this vulnerable population, balancing the demonstrated benefits and risks.

Published
2024
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18. Nutrition of patients with severe neurologic impairment

Author

Orel Anija, Homan Matjaz, Blagus Rok, Benedik Evgen, Orel Rok, and Fidler Mis Natasa

Subjects
malnutrition, severe neurologic impairment, gastrostomy, enteral formula, pureed food, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Commercial enteral formulas are generally recommended for gastrostomy feeding in patients with severe neurologic impairment. However, pureed food diets are still widely used and even gaining popularity among certain groups. We tried to compare the effectiveness of gastrostomy feeding for treatment of severe malnutrition with either enteral formulas or pureed feeds.

Published
2017
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22. Probiotics for the management of pediatric gastrointestinal disorders : position paper of the ESPGHAN special interest group on gut microbiota and modifications

Author

Szajewska, Hania, Berni Canani, Roberto, Domellöf, Magnus, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Lo Vecchio, Andrea, Mihatsch, Walter A., Mosca, Alexis, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van den Akker, Chris H P, van Goudoever, Johannes B., Vandenplas, Yvan, Weizman, Zvi, Szajewska, Hania, Berni Canani, Roberto, Domellöf, Magnus, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Lo Vecchio, Andrea, Mihatsch, Walter A., Mosca, Alexis, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van den Akker, Chris H P, van Goudoever, Johannes B., Vandenplas, Yvan, and Weizman, Zvi

Abstract

BACKGROUND: Probiotics, defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are widely used despite uncertainty regarding their efficacy and discordant recommendations about their use. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Gut Microbiota and Modifications provides updated recommendations for the use of probiotics for the management of selected pediatric gastrointestinal disorders. METHODS: All systematic reviews and/or meta-analyses, as well as subsequently published randomized controlled trials (RCTs) (until December 2021), that compared the use of probiotics in all delivery vehicles and formulations, at any dose, with no probiotic (ie, placebo or no treatment), were eligible for inclusion. The recommendations were formulated only if at least 2 RCTs on a similar well-defined probiotic strain were available. The modified Delphi process was used to establish consensus on the recommendations. RESULTS: Recommendations for the use of specific probiotic strains were made for the management of acute gastroenteritis, prevention of antibiotic-associated diarrhea, nosocomial diarrhea and necrotizing enterocolitis, management of Helicobacter pylori infection, and management of functional abdominal pain disorders and infant colic. CONCLUSIONS: Despite evidence to support the use of specific probiotics in some clinical situations, further studies confirming the effect(s) and defining the type, dose, and timing of probiotics are still often required. The use of probiotics with no documented health benefits should be discouraged.

Published
2023
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23. Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER)

Author

Hoofien, Assaf, Dias, Jorge A., Malamisura, Monica, Rea, Francesca, Chong, Sonny, Oudshoorn, Johanna, Nijenhuis-Hendriks, Danielle, Otte, Sebastian, Papadopoulou, Alexandra, Romano, Claudio, Gottrand, Frederic, Miravet, Victor V., Orel, Rok, Oliva, Salvatore, Junquera, Carolina G., Załęski, Andrzej, Urbonas, Vaidotas, Garcia-Puig, Roger, Gomez, Maria J.M., Dominguez-Ortega, Gloria, Auth, Marcus K.-H., Kori, Michal, Ben Tov, Amir, Kalach, Nicolas, Velde, Saskia V., Furman, Mark, Miele, Erasmo, Marderfeld, Luba, Roma, Eleftheria, and Zevit, Noam

Published
2019
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27. Training in pediatric hepatology across Europe

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, Baker, Alastair, Kelly, Deirdre, Ribes-Koninckxh, Carmen, Furlano, Raoul, I, and Pediatrics

Subjects
Science & Technology, training, children, Hepatology, nutrition, pediatric gastroenterology, Gastroenterology & Hepatology, Gastroenterology, ADOLESCENT, GUIDELINES, DISEASE, PERCUTANEOUS LIVER-BIOPSY, Training, pediatric hepatology, Europe, survey, Life Sciences & Biomedicine, ADULT HEALTH-CARE, POSITION PAPER, TRANSITION
Abstract

BACKGROUND: The widely recognized burden of liver diseases makes training in pediatric hepatology (PH) imperative. The aim of this survey, which was part of a global survey on training in pediatric gastroenterology, hepatology and nutrition (PGHN) across Europe, was to assess the PH and liver transplantation (LT) infrastructure, staff and training programs in PGHN training centers. METHOD: Standardized questionnaires were collected from training centers via the presidents/representatives of the National Societies Network of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) from June 2016 to December 2019. RESULTS: A total of 100 PGHN training centers participated in the survey (14/100 were national referral centers in PH and/or LT). Dedicated PH clinics were available in 75%, but LT clinics in only 11%. Dedicated beds for PGHN inpatients were available in 47/95 (49%) centers. Full-time or part-time specialists for PH care were available in 31/45 (69%) and 11/36 (31%) centers, respectively. Liver biopsies (LB) were performed in 93% of centers by: a PGHN specialist (35%); an interventional radiologist (26%); a pediatric surgeon (4%); or a combination of them (35%). Dividing the annual number of LBs in the centers performing LBs by the number of trainees gave a median (range) of 10 (1-125) per trainee. Transient elastography was available in 60/92 (65%) of centers. CONCLUSIONS: The survey highlighted the differences and shortcomings in PH training across Europe. ESPGHAN should take initiatives together with National Societies to ensure the acquisition of PH knowledge and skills according to the ESPGHAN curriculum.An infographic is available for this article at: http://www.annalsgastro.gr/files/journals/1/earlyview/2022/Infographic-Hepatology-training-paper.pdf. ispartof: ANNALS OF GASTROENTEROLOGY vol:35 issue:2 pages:187-+ ispartof: location:Greece status: published

Published
2022

28. Association of training standards in pediatric gastroenterology, hepatology and nutrition in European training centers with formal national recognition of the subspecialty:a survey of the ESPGHAN National Societies Network 2016-2019

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, Thomson, Mike, Benninga, Marc, Thapar, Nikhil, Kelly, Deirdre, Koletzko, Berthold, Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I, Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidota, Kansu, Aydan, Georgieva, Miglena, Thomson, Mike, Benninga, Marc, Thapar, Nikhil, Kelly, Deirdre, Koletzko, Berthold, and Pediatrics

Subjects
Science & Technology, Gastroenterology & Hepatology, SYLLABUS, Gastroenterology, Training in pediatric gastroenterology, hepatology and nutrition, ESPGHAN, GUIDELINES, Life Sciences & Biomedicine
Abstract

BACKGROUND: This survey evaluated the effects of the recognition of pediatric gastroenterology, hepatology and nutrition (PGHN) on European PGHN training centers. METHOD: Standardized questionnaires were collected from training centers via the presidents/representatives of the National Societies Network of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, from June 2016 to December 2019. RESULTS: A total of 100 training centers from 19 countries participated in the survey: 55 from 12 countries where PGHN is formally recognized (Group 1) and 45 from 7 countries where it is not (Group 2). Training centers in Group 2 were less likely to have an integrated endoscopy suite, a written training curriculum and a training lead (P=0.059, P

Published
2022

29. Comparison of a Web-Based Dietary Assessment Tool with Software for the Evaluation of Dietary Records / Primerjava Spletne Aplikacije in Računalniškega Programa Za Ovrednotenje Prehranskih Dnevnikov

Author

Benedik Evgen, Koroušić Seljak Barbara, Hribar Maša, Rogelj Irena, Bratanič Borut, Orel Rok, and Fidler Mis Nataša

Subjects
web-based dietary assessment tools, dietary records, comparison, pregnant women, spletne aplikacije za ovrednotenje prehranskih dnevnikov, prehranski dnevniki, primerjava, nosečnice, Public aspects of medicine, RA1-1270
Abstract

Izhodišča. V klinični praksi za ovrednotenje prehranskih dnevnikov običajno uporabljamo računalniško podporo, bodisi v obliki računalniškega programa ali spletne aplikacije. Namen članka je predstaviti rezultate primerjave nemškega računalniškega programa in slovenske spletne aplikacije za ovrednotenje prehranskega vnosa na osnovi metode štiridnevnega papirnega tehtanega prehranskega dnevnika (papirni PD), ki so ga vodile nosečnice.

Published
2015
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30. Pediatric endoscopy training across Europe: a survey of the ESPGHAN National Societies Network 2016–2019

Author

Papadopoulou, Alexandra, additional, Ribes-Koninckx, Carmen, additional, Baker, Alastair, additional, Noni, Maria, additional, Koutri, Eleni, additional, Karagianni, Maria-Vasiliki, additional, Protheroe, Sue, additional, Guarino, Alfredo, additional, Mas, Emmanuel, additional, Wilschanski, Michael, additional, Roman, Enriqueta, additional, Escher, Johanna, additional, Furlano, Raoul I., additional, Posovszky, Carsten, additional, Hoffman, Ilse, additional, Bronsky, Jiri, additional, Hauer, Almuthe Christine, additional, Tjesic-Drinkovic, Duska, additional, Fotoulaki, Maria, additional, Orel, Rok, additional, Urbonas, Vaidotas, additional, Kansu, Aydan, additional, Georgieva, Miglena, additional, and Thomson, Mike, additional

Published
2022
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32. Use of Probiotics for the Management of Acute Gastroenteritis in Children: An Update

Author

Working Group on Probiotics and Prebiotics of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, Szajewska, Hania, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Kolacek, Sanja, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van Goudoever, Johannes B, Vandenplas, Yvan, Weizman, Zvi, Zalewski, Bartłomiej M, Neonatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, Faculty of Medicine and Pharmacy, Clinical sciences, Growth and Development, Pediatrics, Szajewska, Hania, Guarino, Alfredo, Hojsak, Iva, Indrio, Flavia, Kolacek, Sanja, Orel, Rok, Salvatore, Silvia, Shamir, Raanan, van Goudoever, Johannes B, Vandenplas, Yvan, Weizman, Zvi, and Zalewski, Bartłomiej M

Subjects
Diarrhea, Limosilactobacillus reuteri, medicine.medical_specialty, MEDLINE, law.invention, 03 medical and health sciences, Probiotic, 0302 clinical medicine, Randomized controlled trial, Lactobacillus rhamnosus, law, 030225 pediatrics, Internal medicine, Humans, Medicine, Pediatrics, Perinatology, and Child Health, acute gastroenteritis, Child, Children, biology, Lacticaseibacillus rhamnosus, business.industry, Probiotics, Gastroenterology, Infant, food and beverages, Acute gastroenteritis, biology.organism_classification, Gastroenteritis, Lactobacillus reuteri, Practice Guidelines as Topic, Pediatrics, Perinatology and Child Health, 030211 gastroenterology & hepatology, medicine.symptom, business, Saccharomyces boulardii
Abstract

Since the publication of the 2014 European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Working Group (WG) on Probiotics and Prebiotics guidelines for the management of acute gastroenteritis (AGE), new evidence concerning the efficacy of probiotics has become available. This document provides updated recommendations on the use of probiotics for the treatment of AGE in previously presumed healthy infants and children. A systematic literature search was performed. All pooled analyses were explicitly performed for the current report. The WG graded the recommendations and assessed the certainty of the supporting evidence using the Grading of Recommendations, Assessment Development, and Evaluations tool. The recommendations were formulated if at least 2 randomized controlled trials that used a given probiotic were available. Despite the large number of identified trials, the WG could not identify 2 randomized controlled trial of high quality for any strain that provided benefit when used for treating AGE. The WG made weak recommendations for (in descending order in terms of the number of trials evaluating any given strain): Saccharomyces boulardii (low to very low certainty of evidence); Lactobacillus rhamnosus GG (very low certainty of evidence); L reuteri DSM 17938 (low to very low certainty of evidence); and L rhamnosus 19070-2 and L reuteri DSM 12246 (very low certainty of evidence). The WG made a strong recommendation against L helveticus R0052 and L rhamnosus R0011 (moderate certainty of evidence) and a weak recommendation against Bacillus clausii strains O/C, SIN, N/R, and T (very low certainty of evidence).

Published
2020

33. Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN

Author

Oliva, Salvatore, Dias, Jorge Amil, Rea, Francesca, Malamisura, Monica, Espinheira, Maria Céu, Papadopoulou, Alexandra, Koutri, Eleni, Rossetti, Danilo, Orel, Rok, Homan, Matjaž, Bauraind, Olivia, Auth, Marcus Karl-Heinz, Junquera, Carolina Gutierrez, Vande Velde, Saskia, Kori, Michal, Huysentruyt, Koen, Urbonas, Vaidotas, Roma, Eleftheria, Fernández, Sonia Fernández, Domínguez-Ortega, Gloria, Zifman, Eyal, Kafritsa, Panayota, Miele, Erasmo, Zevit, Noam, Oliva, Salvatore, Dias, Jorge Amil, Rea, Francesca, Malamisura, Monica, Espinheira, Maria Céu, Papadopoulou, Alexandra, Koutri, Eleni, Rossetti, Danilo, Orel, Rok, Homan, Matjaž, Bauraind, Olivia, Auth, Marcus Karl-Heinz, Junquera, Carolina Gutierrez, Vande Velde, Saskia, Kori, Michal, Huysentruyt, Koen, Urbonas, Vaidota, Roma, Eleftheria, Fernández, Sonia Fernández, Domínguez-Ortega, Gloria, Zifman, Eyal, Kafritsa, Panayota, Miele, Erasmo, Zevit, Noam, Clinical sciences, Growth and Development, and Pediatrics

Subjects
Proton Pump Inhibitors/therapeutic use, Male, Delayed Diagnosis, Adolescent, gastroenterology, Proton Pump Inhibitors, Eosinophilic Esophagitis, Endoscopy, Gastrointestinal, Enteritis, Eosinophilic Esophagitis/complications, Child, Preschool, Gastritis, Pediatrics, Perinatology and Child Health, Eosinophilia, Humans, Female, Deglutition Disorders/drug therapy, Pediatrics, Perinatology, and Child Health, Registries, Child, Deglutition Disorders, Food Hypersensitivity
Abstract

OBJECTIVES: Few pediatric data on phenotypic aspects of eosinophilic esophagitis (EoE) are available. The pEEr registry was developed to prospectively characterize children with EoE from Europe and Israel. METHODS: pEEr is an ongoing prospective registry enrolling children with esophageal eosinophilia (≥15 eos/HPF). Anonymized data were collected from 19 pediatric centers. Data regarding demographics, clinical manifestations, endoscopy, histology, and therapies were collected. RESULTS: A total of 582 subjects (61% male) were analyzed. The median age at diagnosis was 10.5 years [interquartile range (IQR): 5.7-17.7], whereas the age at symptom onset was 9.2 years (IQR: 4.3-16.4), resulting in a median diagnostic delay of 1.2 years (IQR: 0.7-2.3). The diagnostic delay was longer below age

Published
2022

37. Paediatric Gastrointestinal Endoscopy: European Society for Paediatric Gastroenterology Hepatology and Nutrition and European Society of Gastrointestinal Endoscopy Guidelines

Author

Thomson, Mike, Tringali, Andrea, Dumonceau, Jean-Marc, Tavares, Marta, Tabbers, Merit M., Furlano, Raoul, Spaander, Manon, Hassan, Cesare, Tzvinikos, Christos, Ijsselstijn, Hanneke, Viala, Jérôme, Dall’Oglio, Luigi, Benninga, Marc, Orel, Rok, Vandenplas, Yvan, Keil, Radan, Romano, Claudio, Brownstone, Eva, Hlava, Štěpán, Gerner, Patrick, Dolak, Werner, Landi, Rosario, Huber, Wolf D., Everett, Simon, Vecsei, Andreas, Aabakken, Lars, Amil-Dias, Jorge, and Zambelli, Alessandro

Published
2017
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39. Contributors

Author

Abdolghaffari, Amir Hossein, primary, Abdollahi, Mohammad, additional, Ahanchian, Hamid, additional, Ahmad, Farah N., additional, Akbarzadeh, Fariborz, additional, Alighieri, Giovanni, additional, Amini, Amir, additional, Anadón, Arturo, additional, Anania, Caterina, additional, Annibale, Bruno, additional, Arena, Mattia Pia, additional, Arena, Angela, additional, Arés, Irma, additional, Argyri, Anthoula A., additional, Aslim, Belma, additional, Aydaş, Selcen Babaoğlu, additional, Azimi, Amirreza, additional, Ballesteros, Antonio O., additional, Barbosa, Joana, additional, Bastani, Parvin, additional, Bedani, Raquel, additional, Betta, Pasqua, additional, Biglu, Mohammad-Hossein, additional, Borges, Sandra, additional, Bucci, C., additional, Buriti, Flávia C.A., additional, Camacho-Ruiz, R.M., additional, Capozzi, Vittorio, additional, Catenazzi, Piero, additional, Celani, Camilla, additional, Chaluvadi, Saikiran, additional, Champagne, Claude P., additional, Chiesa, Claudio, additional, Clark, Eva H., additional, Collier, Robert J., additional, Colombo, Jacopo, additional, de Moreno de LeBlanc, Alejandra, additional, de Morais, Elisa Carvalho, additional, Dekker, M., additional, Di Venere, D., additional, Drago, Lorenzo, additional, Farnworth, Edward R., additional, Feleszko, Wojciech, additional, Fernandez-Arrojo, Lucia, additional, Fernández-López, J., additional, Finamore, Alberto, additional, Fiocco, Daniela, additional, Gatesoupe, F.J., additional, Ghasemi-Niri, Farnaz, additional, Giacchi, Valentina, additional, Golkhalkhali, Babak, additional, Gomez-Zavaglia, A., additional, Gooshe, Maziar, additional, Gundogdu, Zuhal, additional, Hanning, Irene, additional, Hashemi, Seyed Mohammad Bagher, additional, Hemalatha, Rajkumar, additional, Homayouni, Aziz, additional, Hotchkiss, Arland T., additional, Iovino, P., additional, Saad, Susana Marta Isay, additional, Jafarabadi, Mohammad Asghari, additional, Jafari, Seyed Ali, additional, Jamaluddin, Rosita, additional, Jeong, Ji-Kang, additional, Jirillo, Felicita, additional, Jirillo, Emilio, additional, Jones, Rheinallt M., additional, Kaur, Baljinder, additional, Kaur, Gaganjot, additional, Keshtiban, Ata K., additional, Khalili, Mohammad, additional, Khalili, Leyla, additional, Khalili, Leila, additional, Kirmiz, Nina, additional, Kumar, Manoj, additional, Lahner, Edith, additional, Lavermicocca, P., additional, LeBlanc, Jean Guy, additional, Likotrafiti, Eleni, additional, Lim, Ying-Jye, additional, Lingbeck, Jody, additional, López, Paloma, additional, Mohedano, Mª Luz, additional, Magrone, Thea, additional, Mahdavi, Reza, additional, Maleki, Davood, additional, Mallah, Fatemeh, additional, Marathe, Shreesh J., additional, Marotta, Francesco, additional, Martínez, María Aránzazu, additional, Martinez-Augustin, O., additional, Martínez-Larrañaga, María Rosa, additional, Mehrabany, Elnaz Vaghef, additional, Mills, David A., additional, Stover, Mitchel Graham, additional, Mobili, P., additional, Mohammad, Diya, additional, Mohammad-Alizadeh-Charandabi, Sakineh, additional, Redzwan, S. Mohd, additional, Monedero, Vicente, additional, Moreno Villares, Jose M., additional, Moreno-Vilet, L., additional, Morrow, Lee E., additional, Motoori, Masaaki, additional, Murthy, Jayasimha N., additional, Nácher-Vázquez, Montserrat, additional, Nagpal, Ravinder, additional, Nielsen, Dennis Sandris, additional, Nikniaz, Hossein, additional, Nikniaz, Leila, additional, Nikniaz, Zeinab, additional, Notararigo, Sara, additional, Nunes, Vânia dos Santos, additional, Orel, Rok, additional, Osman, Ali, additional, Ouwehand, Arthur C., additional, Pacifico, Lucia, additional, Panagou, Efstathios Z., additional, Park, Kun-Young, additional, Payahoo, Laleh, additional, Peluso, Ilaria, additional, Pérez-Alvarez, J.A., additional, Pérez-Ramos, Adrian, additional, Plou, Francisco J., additional, Poorbaghi, Seyedeh Leila, additional, Portales-Pérez, D.P., additional, Quigley, Eamonn M.M., additional, Ranjbar, Fatemeh, additional, Reberšak, Lea Vodušek, additional, Rhoades, Jonathan, additional, Ricke, Steven C., additional, Rodriguez-Colinas, Barbara, additional, Rodríguez-Díaz, Jesús, additional, Romano, N., additional, Russo, Pasquale, additional, Russo, F., additional, Ruszczyński, Marek, additional, Saad, Susana M.I., additional, de Medina, F. Sánchez, additional, Santonicola, A., additional, Sayas-Barberá, M.E., additional, Sciacca, Pietro, additional, Scorrano, Antonio, additional, Sendra, E., additional, Sepehrimanesh, Masood, additional, Serafini, Mauro, additional, Shek, Lynette Pei-Chi, additional, Shokrvash, Behjat, additional, Sisto, A., additional, Sivieri, Katia, additional, Skalkam, Maria Lena, additional, Soh, Shu-E, additional, Spano, Giuseppe, additional, Sugimura, Keijiro, additional, Tanaka, Koji, additional, Tassou, Chrysoula C., additional, Teixeira, Paula, additional, Tennilä, Julia, additional, Toscano, Marco, additional, Tripathi, Alok S., additional, Tymczyszyn, E., additional, Valerio, F., additional, van Zanten, Gabriella, additional, Villas Boas, Paulo José Fortes, additional, Wachholz, Patrick Alexander, additional, Watson, Ronald Ross, additional, Wiese, Maria, additional, Yadav, Hariom, additional, Yam, Kit L., additional, Yano, Masahiko, additional, Zeng, Hongliang, additional, Zhang, Yi, additional, Zheng, Baodong, additional, Ziyadi, Somayeh, additional, and Zuppa, Antonio Alberto, additional

Published
2016
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42. Functional gastro-intestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies

Author

Vandenplas, Yvan, Benninga, Marc, Broekaert, Ilse, Falconer, Jackie, Gottrand, Frederic, Guarino, Alfredo, Lifschitz, Carlos, Lionetti, Paolo, Orel, Rok, Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Ruemmele, Frank M., Salvatore, Silvia, Shamir, Raanan, Schäppi, Michela, Staiano, Annamaria, Szajewska, Hania, Thapar, Nikhil, and Wilschanski, Michael

Published
2016
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43. Probiotics and Preterm Infants: A Position Paper by the ESPGHAN Committee on Nutrition and the ESPGHAN Working Group for Probiotics and Prebiotics

Author

van den Akker, Chris H P, van Goudoever, Johannes B, Shamir, Raanan, Domellöf, Magnus, Embleton, Nicholas D, Hojsak, Iva, Lapillonne, Alexandre, Mihatsch, Walter A, Canani, Roberto Berni, Bronsky, Jiri, Campoy, Cristina, Fewtrell, Mary S, Mis, Nataša Fidler, Guarino, Alfredo, Hulst, Jessie M, Indrio, Flavia, Kolaček, Sanja, Orel, Rok, Vandenplas, Yvan, Weizman, Zvi, Szajewska, Hania, van den Akker, Chris H P, van Goudoever, Johannes B, Shamir, Raanan, Domellöf, Magnu, Embleton, Nicholas D, Hojsak, Iva, Lapillonne, Alexandre, Mihatsch, Walter A, Canani, Roberto Berni, Bronsky, Jiri, Campoy, Cristina, Fewtrell, Mary S, Mis, Nataša Fidler, Guarino, Alfredo, Hulst, Jessie M, Indrio, Flavia, Kolaček, Sanja, Orel, Rok, Vandenplas, Yvan, Weizman, Zvi, and Szajewska, Hania

Abstract

More than 10,000 preterm infants have participated in randomised controlled trials on probiotics worldwide, suggesting that probiotics in general could reduce rates of necrotising enterocolitis (NEC), sepsis, and mortality. However, answers to relevant clinical questions as to which strain to use, at what dosage, and how long to supplement, are not available. On the other hand, an increasing number of commercial products containing probiotics are available from sometimes suboptimal quality. Also, a large number of units around the world are routinely offering probiotic supplementation as the standard of care despite lacking solid evidence. Our recent network meta-analysis identified probiotic strains with greatest efficacy regarding relevant clinical outcomes for preterm neonates. Efficacy in reducing mortality and morbidity was found for only a minority of the studied strains or combinations. In the present position paper, we aim to provide advice which specific strains might potentially be used and which strains should not be used. Besides, we aim to address safety issues of probiotic supplementation to preterm infants, who have reduced immunological capacities and occasional indwelling catheters. For example, quality reassurance of the probiotic product is essential, probiotic strains should be devoid of transferable antibiotic resistance genes, and local microbiologists should be able to routinely detect probiotic sepsis. Provided all safety issues are met, there is currently a conditional recommendation (with low certainty of evidence) to provide either L. rhamnosus GG ATCC53103 or the combination of B. infantis Bb-02, B. lactis Bb-12, and Str. thermophilus TH-4 in order to reduce NEC rates.

Published
2020

49. The Use of Fecal Calprotectin Testing in Paediatric Disorders: A Position Paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee

Author

Koninckx, Carmen Ribes, Donat, Ester, Benninga, Marc A., Broekaert, Ilse J., Gottrand, Frederic, Kolho, Kaija-Leena, Lionetti, Paolo, Miele, Erasmo, Orel, Rok, Papadopoulou, Alexandra, Pienar, Corina, Schappi, Michela G., Wilschanski, Michael, Thapar, Nikhil, Koninckx, Carmen Ribes, Donat, Ester, Benninga, Marc A., Broekaert, Ilse J., Gottrand, Frederic, Kolho, Kaija-Leena, Lionetti, Paolo, Miele, Erasmo, Orel, Rok, Papadopoulou, Alexandra, Pienar, Corina, Schappi, Michela G., Wilschanski, Michael, and Thapar, Nikhil

Abstract

Objectives: The aim of the study was to review the evidence regarding the clinical use and value of fecal calprotectin (FC) measurements in different gastrointestinal disorders in children. Methods: A literature search was conducted in the PubMed, MEDLINE, EMBASE, and Cochrane databases until October 31, 2019. Subtopics were identified and each assigned to individual authors. Results: A total of 28 recommendations were voted on using the nominal voting technique. Recommendations are given related to sampling, measurement methods, and results interpretation. The 14 authors anonymously voted on each recommendation using a 9-point scale (1 strongly disagree to 9 fully agree). Consensus was considered achieved if at least 75% of the authors voted 6, 7, 8, or 9. Conclusions: Consensus was reached for all recommendations. Limitations for the use of FC in clinical practice include variability in extraction methodology, performance of test kits as well as the need to establish local reference ranges because of the influence of individual factors, such as age, diet, microbiota, and drugs. The main utility of FC measurement at present is in the diagnosis and monitoring of inflammatory bowel disease (IBD) as well as to differentiate it from functional gastrointestinal disorders (FAPDs). FC, however, has neither utility in the diagnosis of infantile colic nor to differentiate between functional and organic constipation. A rise in FC concentration, may alert to the risk of developing necrotizing enterocolitis and help identifying gastrointestinal involvement in children with Henoch-Schonlein purpura. FC measurement is of little value in Cow's Milk Protein Allergy, coeliac disease (CD), and cystic fibrosis. FC does neither help to distinguish bacterial from viral acute gastroenteritis (AGE), nor to diagnose Helicobacter Pylori infection, small intestinal bacterial overgrowth (SIBO), acute appendicitis (AA), or intestinal polyps.

Published
2021

50. Management of Gastrointestinal and Nutritional Problems in Children With Neurological Impairment: A Survey of Practice

Author

Romano, Claudio, Dipasquale, Valeria, Van Winckel, Myriam, Hulst, Jessie, Broekaert, Ilse, Bronsky, Jiri, Dall'Oglio, Luigi, Mis, Natasa Fidler, Hojsak, Iva, Orel, Rok, Papadopoulou, Alexandra, Schaeppi, Michela, Thapar, Nikhil, Wilschanski, Michael, Sullivan, Peter, Gottrand, Frederic, Romano, Claudio, Dipasquale, Valeria, Van Winckel, Myriam, Hulst, Jessie, Broekaert, Ilse, Bronsky, Jiri, Dall'Oglio, Luigi, Mis, Natasa Fidler, Hojsak, Iva, Orel, Rok, Papadopoulou, Alexandra, Schaeppi, Michela, Thapar, Nikhil, Wilschanski, Michael, Sullivan, Peter, and Gottrand, Frederic

Abstract

Objectives: The main aim of this study was to determine the impact on clinical practice of the first European Society of Gastroenterology, Hepatology, and Nutrition (ESPGHAN) position paper on the diagnosis and management of nutritional and gastrointestinal problems in children with neurological impairment (NI). Methods: In this pilot-study, a web-based questionnaire was distributed between November, 2019 and June, 2020, amongst ESPGHAN members using the ESPGHAN newsletter. Fifteen questions covered the most relevant aspects on nutritional management and gastrointestinal issues of children with NI. A descriptive analysis of responses was performed. Results: A total of 150 health professionals from 23 countries responded to the survey. A considerable variation in clinical practice concerning many aspects of nutritional and gastrointestinal management of children with NI was observed. The most frequently used method for diagnosing oropharyngeal dysfunction was the direct observation of meals with or without the use of standardised scores (n = 103). Anthropometric measurements were the most commonly used tools for assessing nutritional status (n = 111). The best treatment for gastroesophageal reflux disease (GERD) was considered to be proton pump inhibitor therapy by most (n = 116) participants. Regarding tube feeding, nearly all respondents (n = 114) agreed that gastrostomy is the best enteral access to be used for long-term enteral feeding. Fundoplication was indicated at the time of gastrostomy placement especially in case of uncontrolled GERD. Conclusions: More studies are required to address open questions on adequate management of children with NI. Identifying knowledge gaps paves the way for developing updated recommendations and improving patient care.

Published
2021

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