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4. Enhanced recovery after radical cystectomy: Outcomes of implementation after 80 cases

Author

Serra, A. Abella, primary, González, J. A. Jerez, additional, Orejas, M. Serrallach, additional, Reggeti, J. I. Pérez, additional, Parejo, C. Ferreiro, additional, De Pablos Rodriguez, P., additional, Serra, P. Sanz, additional, Escudero, C. Alvarez, additional, Novo, J. F. Suárez, additional, Español, L. Gallego, additional, and Julià, F. Vigués, additional

Published
2022
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17. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Author

de Vries, RP, Riley, R, Wiebenga, A, Aguilar-Osorio, G, Amillis, S, Uchima, CA, Anderluh, G, Asadollahi, M, Askin, M, Barry, K, Battaglia, E, Bayram, Ö, Benocci, T, Braus-Stromeyer, SA, Caldana, C, Cánovas, D, Cerqueira, GC, Chen, F, Chen, W, Choi, C, Clum, A, dos Santos, RAC, de Lima Damásio, AR, Diallinas, G, Emri, T, Fekete, E, Flipphi, M, Freyberg, S, Gallo, A, Gournas, C, Habgood, R, Hainaut, M, Harispe, ML, Henrissat, B, Hildén, KS, Hope, R, Hossain, A, Karabika, E, Karaffa, L, Karányi, Z, Kraševec, N, Kuo, A, Kusch, H, LaButti, K, Lagendijk, EL, Lapidus, A, Levasseur, A, Lindquist, E, Lipzen, A, Logrieco, AF, MacCabe, A, Mäkelä, MR, Malavazi, I, Melin, P, Meyer, V, Mielnichuk, N, Miskei, M, Molnár, ÁP, Mulé, G, Ngan, CY, Orejas, M, Orosz, E, Ouedraogo, JP, Overkamp, KM, Park, HS, Perrone, G, Piumi, F, Punt, PJ, Ram, AFJ, Ramón, A, Rauscher, S, Record, E, and Riaño-Pachón, DM

Abstract

© 2017 The Author(s). Background: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.

Published
2017

18. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Author

de Vries, R.P. Riley, R. Wiebenga, A. Aguilar-Osorio, G. Amillis, S. Uchima, C.A. Anderluh, G. Asadollahi, M. Askin, M. Barry, K. Battaglia, E. Bayram, O. Benocci, T. Braus-Stromeyer, S.A. Caldana, C. Cánovas, D. Cerqueira, G.C. Chen, F. Chen, W. Choi, C. Clum, A. dos Santos, R.A.C. de Lima Damásio, A.R. Diallinas, G. Emri, T. Fekete, E. Flipphi, M. Freyberg, S. Gallo, A. Gournas, C. Habgood, R. Hainaut, M. Harispe, M.L. Henrissat, B. Hildén, K.S. Hope, R. Hossain, A. Karabika, E. Karaffa, L. Karányi, Z. Kraševec, N. Kuo, A. Kusch, H. LaButti, K. Lagendijk, E.L. Lapidus, A. Levasseur, A. Lindquist, E. Lipzen, A. Logrieco, A.F. MacCabe, A. Mäkelä, M.R. Malavazi, I. Melin, P. Meyer, V. Mielnichuk, N. Miskei, M. Molnár, A.P. Mulé, G. Ngan, C.Y. Orejas, M. Orosz, E. Ouedraogo, J.P. Overkamp, K.M. Park, H.-S. Perrone, G. Piumi, F. Punt, P.J. Ram, A.F.J. Ramón, A. Rauscher, S. Record, E. Riaño-Pachón, D.M. Robert, V. Röhrig, J. Ruller, R. Salamov, A. Salih, N.S. Samson, R.A. Sándor, E. Sanguinetti, M. Schütze, T. Sepčić, K. Shelest, E. Sherlock, G. Sophianopoulou, V. Squina, F.M. Sun, H. Susca, A. Todd, R.B. Tsang, A. Unkles, S.E. van de Wiele, N. van Rossen-Uffink, D. de Castro Oliveira, J.V. Vesth, T.C. Visser, J. Yu, J.-H. Zhou, M. Andersen, M.R. Archer, D.B. Baker, S.E. Benoit, I. Brakhage, A.A. Braus, G.H. Fischer, R. Frisvad, J.C. Goldman, G.H. Houbraken, J. Oakley, B. Pócsi, I. Scazzocchio, C. Seiboth, B. vanKuyk, P.A. Wortman, J. Dyer, P.S. Grigoriev, I.V.

Abstract

Background: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi. © 2017 The Author(s).

Published
2017

19. Opposite patterns of expression of two Aspergillus nidulans xylanase genes with respect to ambient pH

Author

MacCabe, A.P., Orejas, M., Perez-Gonzalez, J.A., and Ramon, D.

Subjects
Aspergillus -- Research, Binding sites (Biochemistry) -- Analysis, Nucleotides -- Analysis, Hydrogen-ion concentration -- Measurement, Biological sciences
Abstract

The nucleotide sequences of the upstream portion of the xlnA and xlnB genes were determined to elucidate the pH regulation of the expression of the two genes. Two and one consensus PacC binding sites were revealed, indicating that the transcription may be partly controlled by the PacC binding sites. Results of the Northern blotting analysis demonstrated that the alkalinity-mimicking pacC(super c)14 simultaneously leads to increased levels of xlnA transcript and a decrease in the levels of the xlnB messenger.

Published
1998

21. Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase

Author

Sanz, C, Alvarez, MI, Orejas, M, Velayos, A, Eslava, AP, and Benito, EP

Abstract

The Phycomyces blakesleeanus wild-type is yellow, because it accumulates beta-carotene as the main carotenoid. A new carotenoid mutant of this fungus (A486) was isolated, after treatment with ethyl methane sulfonate (EMS), showing a whitish coloration. It accumulates large amounts of phytoene, small quantities of phytofluene, zeta-carotene and neurosporene, in decreasing amounts, and traces of beta-carotene. This phenotype indicates that it carries a leaky mutation affecting the enzyme phytoene dehydrogenase (EC 1.3.-.-), which is specified by the gene carB. Biochemical analysis of heterokaryons showed that mutant A486 complements two previously characterized carB mutants, C5 (carB10) and S442 (carB401). Sequence analysis of the carB gene genomic copy from these three strains revealed that they are all altered in the gene carB, giving information about the nature of the mutation in each carB mutant allele. The interallelic complementation provides evidence for the multimeric organization of the P. blakesleeanus phytoene dehydrogenase.

Published
2016

22. Poster session 4: Friday 5 December 2014, 08:30-12:30Location: Poster area

Author

Orii M, Tanimoto T, Yokoyama M, Ota S, Kubo T, Hirata K, Tanaka A, Imanishi T, Akasaka T, Michelsen M, Pena A, Mygind N, Hoest N, Prescott E, Abd El Dayem S, Battah A, Abd El Azzez F, Ahmed A, Fattoh A, Ismail R, Andjelkovic K, Kalimanovska Ostric D, Nedeljkovic I, Andjelkovic I, Rashid H, Abuel Enien H, Ibraheem M, Vago H, Toth A, Csecs I, Czimbalmos C, Suhai FI, Kecskes K, Becker D, Simor T, Merkely B, D'ascenzi F, Pelliccia A, Natali B, Cameli M, Lisi M, Focardi M, Corrado D, Bonifazi M, Mondillo S, Zaha V, Kim G, Su K, Zhang J, Mikush N, Ross J, Palmeri M, Young L, Tadic M, Ilic S, Celic V, Jaimes C, Gonzalez Mirelis J, Gallego M, Goirigolzarri J, Pellegrinet M, Poli S, Prati G, Vriz O, Di Bello V, Carerj S, Zito C, Mateescu A, Popescu B, Antonini Canterin F, Chatzistamatiou E, Moustakas G, Memo G, Konstantinidis D, Mpampatzeva Vagena I, Manakos K, Traxanas K, Vergi N, Feretou A, Kallikazaros I, Hewing B, Theres L, Dreger H, Spethmann S, Stangl K, Baumann G, Knebel F, Uejima T, Itatani K, Nakatani S, Lancellotti P, Seo Y, Zamorano J, Ohte N, Takenaka K, Naar J, Mortensen L, Johnson J, Winter R, Shahgaldi K, Manouras A, Braunschweig F, Stahlberg M, Coisne D, Al Arnaout AM, Tchepkou C, Raud Raynier P, Diakov C, Degand B, Christiaens L, Barbier P, Mirea O, Cefalu C, Savioli G, Guglielmo M, Maltagliati A, O'neill L, Walsh K, Hogan J, Manzoor T, Ahern B, Owens P, Sengelov M, Biering Sorensen T, Jorgensen P, Bruun N, Fritz Hansen T, Bech J, Olsen F, Sivertsen J, Jensen J, Marta L, Abecasis J, Reis C, Ribeiras R, Andrade M, Mendes M, D'andrea A, Stanziola A, Di Palma E, Martino M, Lanza M, Betancourt V, Maglione M, Calabro' R, Russo M, Bossone E, Vogt MO, Meierhofer Ch, Rutz T, Fratz S, Ewert P, Roehlig Ch, Kuehn A, Storsten P, Eriksen M, Remme E, Boe E, Smiseth O, Skulstad H, Ereminiene E, Ordiene R, Ivanauskas V, Vaskelyte J, Stoskute N, Kazakauskaite E, Benetis R, Marketou M, Parthenakis F, Kontaraki J, Zacharis E, Maragkoudakis S, Logakis J, Roufas K, Vougia D, Vardas P, Dado E, Knuti G, Djamandi J, Shota E, Sharka I, Saka J, Halmai L, Nemes A, Kardos A, Neubauer S, Kurnicka K, Domienik Karlowicz J, Lichodziejewska B, Goliszek S, Grudzka K, Krupa M, Dzikowska Diduch O, Ciurzynski M, Pruszczyk P, Chung H, Kim J, Yoon Y, Min P, Lee B, Hong B, Rim S, Kwon H, Choi E, Soya O, Kuryata O, Kakihara R, Naruse C, Inayoshi A, El Sebaie M, Frer A, Abdelsamie M, Eldamanhory A, Ciampi Q, Cortigiani L, Simioniuc A, Manicardi C, Villari B, Picano E, Sicari R, Ferferieva V, Deluyker D, Lambrichts I, Rigo J, Bito V, Kuznetsov V, Yaroslavskaya E, Krinochkin D, Pushkarev G, Gorbatenko E, Trzcinski P, Michalski B, Lipiec P, Szymczyk E, Peczek L, Nawrot B, Chrzanowski L, Kasprzak J, Todaro M, Khandheria B, Cusma Piccione M, La Carrubba S, Oreto G, Di Bella G, Gunyeli E, Oliveira Da Silva C, Sahlen A, Spampinato R, Tasca M, Roche E. Silva J, Strotdrees E, Schloma V, Dmitrieva Y, Dobrovie M, Borger M, Mohr F, Einarsen E, Cramariuc D, Lonnebakken M, Boman K, Gohlke Barwolf C, Chambers J, Gerdts E, Calin A, Rosca M, Beladan C, Mirescu Craciun A, Gurzun M, Enache R, Ginghina C, Antova E, Georgievska Ismail Lj, Srbinovska E, Andova V, Peovska I, Davceva J, Otljanska M, Vavulkis M, Tsuruta H, Kohsaka S, Murata M, Yasuda R, Dan M, Yashima F, Inohara T, Maekawa Y, Hayashida K, Fukuda K, Migliore R, Adaniya M, Barranco M, Miramont G, Gonzalez S, Tamagusuku H, Abid L, Ben Kahla S, Charfeddine S, Abid D, Kammoun S, Amano M, Izumi C, Miyake M, Tamura T, Kondo H, Kaitani K, Nakagawa Y, Ghulam Ali S, Fusini L, Tamborini G, Muratori M, Gripari P, Bottari V, Celeste F, Cefalu' C, Alamanni F, Pepi M, Obase K, Mor Avi V, Weinert L, Lang R, Teixeira R, Monteiro R, Garcia J, Ribeiro M, Cardim N, Goncalves L, Miglioranza M, Muraru D, Cavalli G, Addetia K, Cucchini U, Mihaila S, Veronesi F, Badano L, Galian Gay L, Gonzalez Alujas M, Teixido Tura G, Gutierrez Garcia L, Rodriguez Palomares J, Evangelista Masip A, Conte L, Fabiani I, Giannini C, La Carruba S, De Carlo M, Barletta V, Petronio A, Mahmoud H, Al Ghamdi M, Ghabashi A, Salaun E, Zenses A, Evin M, Collart F, Pibarot P, Habib G, Rieu R, Fabregat Andres O, Estornell Erill J, Cubillos Arango A, Bochard Villanueva B, Chacon Hernandez N, Higueras Ortega L, Perez Bosca L, Paya Serrano R, Ridocci Soriano F, Cortijo Gimeno J, Mzoughi K, Zairi I, Jabeur M, Ben Moussa F, Mrabet K, Kamoun S, Fennira S, Ben Chaabene A, Kraiem S, Schnell F, Betancur J, Daudin M, Simon A, Lentz P, Tavard F, Hernandes A, Carre F, Garreau M, Donal E, Abduch M, Vieira M, Antunes M, Mathias W, Mady C, Arteaga E, Alencar A, Tesic M, Djordjevic Dikic A, Beleslin B, Giga V, Trifunovic D, Petrovic O, Jovanovic I, Petrovic M, Stepanovic J, Vujisic Tesic B, Cha J, Kim Kh, Bergler Klein J, Geier C, Maurer G, Gyongyosi M, Cortes Garcia M, Oliva M, Navas M, Orejas M, Rabago R, Martinez M, Briongos S, Romero A, Rey M, Farre J, Ruisanchez Villar C, Ruiz Guerrero L, Rubio Ruiz S, Lerena Saenz P, Gonzalez Vilchez F, Hernandez Hernandez J, Armesto Alonso S, Blanco Alonso R, Martin Duran R, Gonzalez Gay M, Novo G, Marturana I, Bonomo V, Arvigo L, Evola V, Karfakis G, Lo Presti M, Verga S, Novo S, Petroni R, Acitelli A, Bencivenga S, Cicconetti M, Di Mauro M, Petroni A, Romano S, Penco M, Park S, Kim S, Kim M, Shim W, Majstorovic A, Ivanovic B, Driessen MM, Meijboom F, Mertens L, Dragulescu A, Friedberg M, De Stefano F, Santoro C, Buonauro A, Muscariello R, Lo Iudice F, Ierano P, Esposito R, Galderisi M, Sunbul M, Kivrak T, Durmus E, Yildizeli B, Mutlu B, Rodrigues A, Daminello E, Echenique L, Cordovil A, Oliveira W, Monaco Ch, Lira E, Fischer Ch, Morhy S, Mignot A, Jaussaud J, Chevalier L, Lafitte S, Curci V, Alvino F, Ikonomidis I, Pavlidis G, Lambadiari V, Kousathana F, Triantafyllidi H, Varoudi M, Dimitriadis G, Lekakis J, Cho JS, Cho E, Yoon H, Ihm Sh, Lee J, Molnar AA, Kovacs A, Apor A, Tarnoki A, Tarnoki D, Horvath T, Maurovich Horvat P, Jermendy G, Kiss R, Al Habbaa A, Petrovic Nagorni S, Ciric Zdravkovic S, Stanojevic D, Jankovic Tomasevic R, Atanaskovic V, Mitic V, Todorovic L, Dakic S, Park JS, Choi J, Kim Sh, Kwon Y, Jin H, Coppola C, Piscopo G, Galletta F, Maurea C, Esposito E, Barbieri A, Maurea N, Kaldararova M, Tittel P, Kantorova A, Vrsanska V, Kollarova E, Hraska V, Nosal M, Ondriska M, Masura J, Simkova I, Tadeu I, Azevedo O, Lourenco M, Luis F, Lourenco A, Planinc I, Bagadur G, Bijnens B, Ljubas J, Baricevic Z, Skoric B, Velagic V, Milicic D, Cikes M, Campanale CM, Di Maria S, Mega S, Nusca A, Marullo F, Di Sciascio G, El Tahlawi M, Abdallah M, Gouda M, Gad M, Elawady M, Igual Munoz B, Maceira Gonzalez Alicia A, Donate Betolin L, Vazquez Sanchez Alejandro A, Valera Martinez F, Sepulveda Sanchez P, Cervera Zamora A, Piquer Gil Marina M, Montero Argudo A, Naka K, Evangelou D, Lakkas L, Kalaitzidis R, Bechlioulis A, Gkirdis I, Tzeltzes G, Nakas G, Pappas K, Michalis L, Mansencal N, Bagate F, Arslan M, Siam Tsieu V, Deblaise J, El Mahmoud R, Dubourg O, Wierzbowska Drabik K, Plewka M, Bandera F, Generati G, Pellegrino M, Alfonzetti E, Labate V, Villani S, Gaeta M, Guazzi M, Grycewicz T, Szymanska K, Grabowicz W, Lubinski A, Sotaquira M, Caiani E, Garcia Gonzalez P, De La Espriella Juan R, Albiach Montanana C, Berenguer Jofresa A, Perez Bosca J, Cheng HL, Huang CH, Wang YC, Chou WH, Melnikov N, Kolunin G, Enina T, Sierraalta W, Le Bihan D, Barretto R, Assef J, Gospos M, Buffon M, Ramos A, Garcia A, Pinto I, Souza A, Mueller H, Reverdin S, Ehret G, Conti L, Dos Santos S, Abdel Moneim SS, Nhola LF, Huang R, Kohli M, Longenbach S, Green M, Villarraga HR, Bordun KA, Jassal DS, Mulvagh SL, Evangelista A, Madeo A, Piras P, Giordano F, Giura G, Teresi L, Gabriele S, Re F, Puddu P, Torromeo C, Suwannaphong S, Vathesatogkit P, See O, Yamwong S, Katekao W, Sritara P, Iliuta L, Szulik M, Streb W, Wozniak A, Lenarczyk R, Sliwinska A, Kalarus Z, Kukulski T, Weng KP, Lin CC, Hein S, Lehmann L, Kossack M, Juergensen L, Katus H, Hassel D, Turrini F, Scarlini S, Giovanardi P, Messora R, Mannucci C, Bondi M, Olander R, Sundholm J, Ojala T, Andersson S, Sarkola T, Karolyi M, Kocsmar I, Raaijmakers R, Kitslaar P, Szilveszter B, Tissue Doppler echocardiography research work, VFM international collaboration group, MTA SE Lendület Cardiovascular Imaging Research Group Heart, Vascular Center Semmelweis University Budapest Hungary, POLICINO, SALVATORE, Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, M, Pena, A, Mygind, N, Hoest, N, Prescott, E, Abd El Dayem, S, Battah, A, Abd El Azzez, F, Ahmed, A, Fattoh, A, Ismail, R, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, H, Abuel Enien, H, Ibraheem, M, Vago, H, Toth, A, Csecs, I, Czimbalmos, C, Suhai, Fi, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'Ascenzi, F, Pelliccia, A, Natali, B, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, V, Kim, G, Su, K, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, L, Tadic, M, Ilic, S, Celic, V, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, B, Antonini Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, J, Ohte, N, Takenaka, K, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, Am, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'Neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Sengelov, M, Biering Sorensen, T, Jorgensen, P, Bruun, N, Fritz Hansen, T, Bech, J, Olsen, F, Sivertsen, J, Jensen, J, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, M, Mendes, M, D'Andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, M, Bossone, E, Vogt, Mo, Meierhofer, Ch, Rutz, T, Fratz, S, Ewert, P, Roehlig, Ch, Kuehn, A, Storsten, P, Eriksen, M, Remme, E, Boe, E, Smiseth, O, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, J, Yoon, Y, Min, P, Lee, B, Hong, B, Rim, S, Kwon, H, Choi, E, Soya, O, Kuryata, O, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, M, Frer, A, Abdelsamie, M, Eldamanhory, A, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, J, Bito, V, Kuznetsov, V, Yaroslavskaya, E, Krinochkin, D, Pushkarev, G, Gorbatenko, E, Trzcinski, P, Michalski, B, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, J, Todaro, M, Khandheria, B, Cusma Piccione, M, La Carrubba, S, Oreto, G, Di Bella, G, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Spampinato, R, Tasca, M, Roche E., Silva J, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, M, Mohr, F, Einarsen, E, Cramariuc, D, Lonnebakken, M, Boman, K, Gohlke Barwolf, C, Chambers, J, Gerdts, E, Calin, A, Rosca, M, Beladan, C, Mirescu Craciun, A, Gurzun, M, Enache, R, Ginghina, C, Antova, E, Georgievska Ismail, Lj, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, M, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Veronesi, F, Badano, L, Galian Gay, L, Gonzalez Alujas, M, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez Palomares, J, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, A, Mahmoud, H, Al Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, A, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos Arango, A, Bochard Villanueva, B, Chacon Hernandez, N, Higueras Ortega, L, Perez Bosca, L, Paya Serrano, R, Ridocci Soriano, F, Cortijo Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, P, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, M, Vieira, M, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, A, Tesic, M, Djordjevic Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic Tesic, B, Cha, J, Kim, Kh, Bergler Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, M, Navas, M, Orejas, M, Rabago, R, Martinez, M, Briongos, S, Romero, A, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, F, Hernandez Hernandez, J, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez Gay, M, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, S, Kim, S, Kim, M, Shim, W, Majstorovic, A, Ivanovic, B, Driessen, Mm, Meijboom, F, Mertens, L, Dragulescu, A, Friedberg, M, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, A, Daminello, E, Echenique, L, Cordovil, A, Oliveira, W, Monaco, Ch, Lira, E, Fischer, Ch, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, Curci, V, Alvino, F, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J, Cho, E, Yoon, H, Ihm, Sh, Lee, J, Molnar, Aa, Kovacs, A, Apor, A, Tarnoki, A, Tarnoki, D, Horvath, T, Maurovich Horvat, P, Jermendy, G, Kiss, R, Al Habbaa, A, Petrovic Nagorni, S, Ciric Zdravkovic, S, Stanojevic, D, Jankovic Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J, Choi, J, Kim, Sh, Kwon, Y, Jin, H, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, I, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, Cm, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, M, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, A, Donate Betolin, L, Vazquez Sanchez Alejandro, A, Valera Martinez, F, Sepulveda Sanchez, P, Cervera Zamora, A, Piquer Gil Marina, M, Montero Argudo, A, Naka, K, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, L, Mansencal, N, Bagate, F, Arslan, M, Siam Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska Drabik, K, Plewka, M, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Caiani, E, Garcia Gonzalez, P, De La Espriella Juan, R, Albiach Montanana, C, Berenguer Jofresa, A, Perez Bosca, J, Cheng, Hl, Huang, Ch, Wang, Yc, Chou, Wh, Melnikov, N, Kolunin, G, Enina, T, Sierraalta, W, Le Bihan, D, Barretto, R, Assef, J, Gospos, M, Buffon, M, Ramos, A, Garcia, A, Pinto, I, Souza, A, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S, Nhola, Lf, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, Hr, Bordun, Ka, Jassal, D, Mulvagh, Sl, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, Kp, Lin, Cc, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, H, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, J, Ojala, T, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, P, Szilveszter, B, Tissue Doppler echocardiography research, Work, VFM international collaboration, Group, MTA SE Lendület Cardiovascular Imaging Research Group, Heart, Vascular Center Semmelweis University Budapest, Hungary, and Policino, Salvatore

Subjects
Medical education, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Friday 5 December 2014, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2014

23. 2186Prevalence and characteristics of anomalous coronary arteries origin from the opposite side in an unselected population of patients undergoing computed tomographic angiography

Author

Rivero Monteagudo, A., primary, Orejas, M., additional, Farre, J., additional, Garcia, A., additional, Tomas, M., additional, Navarro, F., additional, Aldamiz, G., additional, Devesa, A., additional, Navas, M.A., additional, Cortes, M., additional, Rabago, R., additional, and Ibanez, B., additional

Published
2017
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25. Parathormone levels are independently associated with the presence of left ventricular hypertrophy in patients with coronary artery disease

Author

Aceña, Á., primary, Pello, A. M., additional, Carda, R., additional, Lorenzo, Ó., additional, Gonzalez-Casaus, M. L., additional, Blanco-Colio, L. M., additional, Martín-Ventura, J. L., additional, Palfy, J., additional, Orejas, M., additional, Rábago, R., additional, Gonzalez-Parra, E., additional, Mahíllo-Fernández, I., additional, Farré, J., additional, Egido, J., additional, and Tuñón, José, additional

Published
2015
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27. Construction of a genetically modified wine yeast strain expressing the Aspergillus aculeatus rhaA gene, encoding an -L-Rhamnosidase of enological interest

Author

Manzanares, P., Orejas, M., Vicente Gil, J., de Graaff, L.H., Visser, J., Ramon, D., Manzanares, P., Orejas, M., Vicente Gil, J., de Graaff, L.H., Visser, J., and Ramon, D.

Abstract

The Aspergillus aculeatus rhaA gene encoding an alpha-L-rhamnosidase has been expressed in both laboratory and industrial wine yeast strains. Wines produced in microvinifications, conducted using a combination of the genetically modified industrial strain expressing rhaA and another strain expressing a beta-glucosidase, show. increased content mainly of the aromatic compound linalool.

Published
2003

35. The filamentous fungus Aspergillus nidulansproduces an α‐L‐rhamnosidase of potential oenological interest

Author

Orejas, M., Ibáñez, E., and Ramón, D.

Abstract

The production of α‐ l‐rhamnosidase by Aspergillus nidulanshas been investigated. In the presence of rhamnose as sole carbon source, this fungus produces an α‐ l‐rhamnosidase of molecular weight 90 kDa. Production of this enzyme is under carbon catabolite repression, apparently by a CreA‐independent system. At acidic ambient pH there is an increase in the synthesis of the enzyme which is not related to PacC. Using ρ‐nitrophenyl‐α‐ l‐rhamnopyranoside as substrate, the enzyme activity in culture filtrates shows pH and temperature optima of 4·5–8 and 40–50 °C, respectively. At the concentrations found in must or wine, enzyme activity was only slightly affected by glucose and SO2and partly inhibited by ethanol, indicating a potential for use in wine aroma release.

Published
1999
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36. Signaling of ambient pH in Aspergillus involves a cysteine protease.

Author

Denison, S H, Orejas, M, and Arst, H N

Abstract

In Aspergillus nidulans, the regulation of gene expression in response to changes in ambient pH is mediated by the PacC zinc finger transcriptional regulator. At alkaline ambient pH, PacC is proteolytically processed to a functional form serving as an activator of alkaline-expressed genes and a repressor of acid-expressed genes. This activation of PacC occurs in response to a signal mediated by the products of the pal genes. Thus, the products of the palA, -B, -C, -F, -H, and -I genes constitute an alkaline ambient pH signal transduction pathway. How the pal signal transduction pathway senses ambient pH and transduces a signal to trigger PacC processing is a fascinating unresolved problem. We have cloned and sequenced the palB gene. The predicted palB gene product has similarity to the catalytic domain of the calpain family of calcium-activated cysteine proteases. We have shown, however, that the PalB protein does not catalyze the final step of proteolytic processing of PacC.

Published
1995

37. Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Author

Vries, R. P. De, Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Uchima, C. A., Anderluh, G., Asadollahi, M., Askin, M., Barry, K., Battaglia, E., Bayram, O., Benocci, T., Braus-Stromeyer, S. A., Caldana, C., Cánovas, D., Cerqueira, G. C., Chen, F., Chen, W., Choi, C., Clum, A., Santos, R. A. C. Dos, Lima Damásio, A. R. De, Diallinas, G., Emri, T., Fekete, E., Flipphi, M., Freyberg, S., Gallo, A., Gournas, C., Habgood, R., Hainaut, M., Harispe, M. L., Henrissat, B., Hildén, K. S., Hope, R., Hossain, A., Karabika, E., Karaffa, L., Karányi, Z., KrašEvec, N., Kuo, A., Kusch, H., LaButti, K., Lagendijk, E. L., Lapidus, A., Levasseur, A., Lindquist, E., Lipzen, A., Logrieco, A. F., MacCabe, A., Mäkelä, M. R., Malavazi, I., Melin, P., Meyer, V., Mielnichuk, N., Miskei, M., Molnár, A. P., Mulé, G., Ngan, C. Y., Orejas, M., Orosz, E., Ouedraogo, J. P., Overkamp, K. M., Park, H.-S., Perrone, G., Piumi, F., Punt, P. J., Ram, A. F. J., Ramón, A., Rauscher, S., Record, E., Riaño-Pachón, D. M., Robert, V., Röhrig, J., Ruller, R., Salamov, A., Salih, N. S., Samson, R. A., Sándor, E., Sanguinetti, M., Schütze, T., Sep?I?, K., Shelest, E., Sherlock, G., Sophianopoulou, V., Squina, F. M., Sun, H., Susca, A., Todd, R. B., Tsang, A., Unkles, S. E., Wiele, N. Van De, Rossen-Uffink, D. Van, Castro Oliveira, J. V. De, Vesth, T. C., Visser, J., Yu, J.-H., Zhou, M., Andersen, M. R., Archer, D. B., Baker, S. E., Benoit, I., Brakhage, A. A., Braus, G. H., Fischer, R., Frisvad, J. C., Goldman, G. H., Houbraken, J., Oakley, B., Pócsi, I., Scazzocchio, C., Seiboth, B., VanKuyk, P. A., Wortman, J., Dyer, P. S., and Grigoriev, I. V.

Subjects
Fungal biology, Aspergillus, Comparative genomics, 15. Life on land, Genome sequencing, 3. Good health
Abstract

Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.

39. Milestones in wine biotechnology

Author

Ramon, D., Genoves, S., Gil, Jv, Herrero, O., Andrew Peter MacCabe, Manzanares, P., Matallana, E., Orejas, M., Uber, G., and Valles, S.

41. L-Rhamnose induction of Aspergillus nidulans α-L-rhamnosidase genes is glucose repressed via a CreA-independent mechanism acting at the level of inducer uptake

Author

Tamayo-Ramos Juan A, Flipphi Michel, Pardo Ester, Manzanares Paloma, and Orejas Margarita

Subjects
Aspergillus nidulans, Carbon catabolite repression, CreA-independent, Inducer exclusion, α-L-rhamnosidase, Transcriptional regulation, Microbiology, QR1-502
Abstract

Abstract Background Little is known about the structure and regulation of fungal α-L-rhamnosidase genes despite increasing interest in the biotechnological potential of the enzymes that they encode. Whilst the paradigmatic filamentous fungus Aspergillus nidulans growing on L-rhamnose produces an α-L-rhamnosidase suitable for oenological applications, at least eight genes encoding putative α-L-rhamnosidases have been found in its genome. In the current work we have identified the gene (rhaE) encoding the former activity, and characterization of its expression has revealed a novel regulatory mechanism. A shared pattern of expression has also been observed for a second α-L-rhamnosidase gene, (AN10277/rhaA). Results Amino acid sequence data for the oenological α-L-rhamnosidase were determined using MALDI-TOF mass spectrometry and correspond to the amino acid sequence deduced from AN7151 (rhaE). The cDNA of rhaE was expressed in Saccharomyces cerevisiae and yielded pNP-rhamnohydrolase activity. Phylogenetic analysis has revealed this eukaryotic α-L-rhamnosidase to be the first such enzyme found to be more closely related to bacterial rhamnosidases than other α-L-rhamnosidases of fungal origin. Northern analyses of diverse A. nidulans strains cultivated under different growth conditions indicate that rhaA and rhaE are induced by L-rhamnose and repressed by D-glucose as well as other carbon sources, some of which are considered to be non-repressive growth substrates. Interestingly, the transcriptional repression is independent of the wide domain carbon catabolite repressor CreA. Gene induction and glucose repression of these rha genes correlate with the uptake, or lack of it, of the inducing carbon source L-rhamnose, suggesting a prominent role for inducer exclusion in repression. Conclusions The A. nidulans rhaE gene encodes an α-L-rhamnosidase phylogenetically distant to those described in filamentous fungi, and its expression is regulated by a novel CreA-independent mechanism. The identification of rhaE and the characterization of its regulation will facilitate the design of strategies to overproduce the encoded enzyme - or homologs from other fungi - for industrial applications. Moreover, A. nidulans α-L-rhamnosidase encoding genes could serve as prototypes for fungal genes coding for plant cell wall degrading enzymes regulated by a novel mechanism of CCR.

Published
2012
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42. Poster session 4: Friday 5 December 2014, 08:30-12:30 * Location: Poster area

Author

Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, MM, Pena, A, Mygind, ND, Hoest, NB, Prescott, E, Abd El Dayem, SOHA, Battah, AHMED, Abd El Azzez, FATEN, Ahmed, AZZA, Fattoh, AYA, Ismail, REEM, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, HESHAM, Abuel Enien, HESHAM, Ibraheem, MAHER, work, Tissue Doppler echocardiography research, Vago, H, Toth, A, Csecs, I, Czimbalmos, CS, Suhai, F I, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, VG, Kim, GE, Su, KN, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, LH, Tadic, M, Ilic, SI, Celic, VC, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, BA, Antonini-Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, JL, Ohte, N, Takenaka, K, group, VFM international collaboration, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, A-M, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Savioli, G, Guglielmo, M, Mirea, O, Cefalu, C, Barbier, P, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, MJ, Mendes, M, D'andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, MG, Bossone, E, Vogt, M O, Meierhofer, CH, Rutz, TH, Fratz, S, Ewert, P, Roehlig, CH, Kuehn, A, Storsten, P, Eriksen, M, Remme, EW, Boe, E, Smiseth, OA, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, JY, Yoon, YW, Min, PK, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Soya, OV, Kuryata, OV, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, MAHA, Frer, ABDEL, Abdelsamie, MAGDY, Eldamanhory, AHMED, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, 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Vascular, University, Semmelweis, Budapest, Hungary, and Group, MTA-SE Lendület Cardiovascular Imaging Research

Abstract

Purpose: Although delayed-enhancement magnetic resonance imaging (DEMRI) is essential for diagnosis of cardiac sarcoidosis (CS), the test was not available when pacemaker was implamted. Recently, MR-conditional pacemaker has become avilable and we hypothesized that this device would be useful for diagnosis and management of CS. The aim of this study was to assess the diagnostic ability of MR-conditional pacemaker about CS in patients with advanced A-V nodal block (AAVB). Methods: Twenty-seven AAVB patients (14 men, 13 women; mean age, 69 ± 11 years) who were implanted MR-conditional pacemaker were studied. DEMRI was performed 6 weeks after implantation of permanent pacemaker. In patients with positive for DE, additional examinations like echocardiography, radioisotope imaging, biopsy, and coronary computed-tomography were performed due to confirm the diagnosis of CS and exclude coronary artery disease. Results: DE was observed in 12 patients (44 %). Out of 12 patients, 2 patients were excluded for having prior myocardial infarction. Seven of 10 (70 %) patients were diagnosed of CS by the consensus criteria. Compared with non-CS group, CS group had significantly lower age (61 ± 12 years vs. 72 ± 9 years p = 0.017). There was no significant difference about sex, angiotensin-converting enzyme, brain natriuretic peptide, and left ventricular ejection fraction between 2 groups. Six patients had started corticosteroid therapy and 5 patients (83%) recovered A-V nodal conduction. Conclusion: MR-conditional pacemaker was useful for diagnosis and management of patients with AAVB caused by CS. Figure Cardiac MRI in patient with AV block

Published
2014
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47. Dapagliflozin Improved Cardiac Function and Structure in Diabetic Patients with Preserved Ejection Fraction: Results of a Single Centre, Observational Prospective Study.

Author

Cortés M, Lorenzo O, Lumpuy-Castillo J, Martínez-Albaladejo S, Taibo-Urquía M, Pello AM, Bollas AJ, Orejas M, Navas MÁ, Macia E, Martínez ME, Rueda A, and Tuñón J

Abstract

Sodium-glucose cotransporter inhibitors (SGLT2i) have demonstrated a reduction in cardiovascular events in diabetes and heart failure (HF). The mechanisms underlying this benefit are not well known and data are contradictory. The purpose of this study is to analyse the effect of dapagliflozin on cardiac structure and function in patients with normal ejection fraction. Between October 2020 and October 2021, we consecutively included 31 diabetic patients without prior history of SGLT2i use. In all of them, dapagliflozin treatment was started. At inclusion and during six months of follow-up, different clinical, ECG, analytical, and echocardiographic (standard, 3D, and speckle tracking) variables were recorded. After a follow-up period of 6.6 months, an average reduction of 18 g ( p = 0.028) in 3D-estimated left ventricle mass was observed. An increase in absolute left ventricle global longitudinal strain (LV-GLS) of 0.3 ( p = 0.036) was observed, as well as an increase in isovolumetric relaxation time (IVRT) of 10.5 ms ( p = 0.05). Moreover, dapagliflozin decreased the levels of plasma creatin-kinase (CK-MB) and atrial natriuretic peptide (ANP). In conclusion, our data show that the use of SGLT2i is associated with both structural (myocardial mass) and functional (IVRT, LV-GLS) cardiac improvements in a population of diabetic patients with normal ejection fraction.

Published
2023
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49. The Loss-of-Function Mutation aldA67 Leads to Enhanced α-L-Rhamnosidase Production by Aspergillus nidulans .

Author

Orejas M and MacCabe AP

Abstract

In Aspergillus nidulans L-rhamnose is catabolised to pyruvate and L-lactaldehyde, and the latter ultimately to L-lactate, via the non-phosphorylated pathway (LRA) encoded by the genes lraA - D , and aldA that encodes a broad substrate range aldehyde dehydrogenase (ALDH) that also functions in ethanol utilisation. LRA pathway expression requires both the pathway-specific transcriptional activator RhaR ( rhaR is expressed constitutively) and the presence of L-rhamnose. The deletion of lraA severely impairs growth when L-rhamnose is the sole source of carbon and in addition it abolishes the induction of genes that respond to L-rhamnose/RhaR, indicating that an intermediate of the LRA pathway is the physiological inducer likely required to activate RhaR. The loss-of-function mutation aldA67 also has a severe negative impact on growth on L-rhamnose but, in contrast to the deletion of lraA , the expression levels of L-rhamnose/RhaR-responsive genes under inducing conditions are substantially up-regulated and the production of α-L-rhamnosidase activity is greatly increased compared to the aldA + control. These findings are consistent with accumulation of the physiological inducer as a consequence of the loss of ALDH activity. Our observations suggest that aldA loss-of-function mutants could be biotechnologically relevant candidates for the over-production of α-L-rhamnosidase activity or the expression of heterologous genes driven by RhaR-responsive promoters.

Published
2022
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