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2. Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

Author

García-León, Juan Antonio, Cabrera-Socorro, Alfredo, Eggermont, Kristel, Swijsen, Ann, Terryn, Joke, Fazal, Raheem, Nami, FatemehArefeh, Ordovás, Laura, Quiles, Ana, Lluis, Frederic, Serneels, Lutgarde, Wierda, Keimpe, Sierksma, Annerieke, Kreir, Mohamed, Pestana, Francisco, Van Damme, Philip, De Strooper, Bart, Thorrez, Lieven, Ebneth, Andreas, and Verfaillie, Catherine M.

Published
2018
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3. Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Author

Boon, Ruben, Kumar, Manoj, Tricot, Tine, Elia, Ilaria, Ordovas, Laura, Jacobs, Frank, One, Jennifer, De Smedt, Jonathan, Eelen, Guy, Bird, Matthew, Roelandt, Philip, Doglioni, Ginevra, Vriens, Kim, Rossi, Matteo, Vazquez, Marta Aguirre, Vanwelden, Thomas, Chesnais, François, El Taghdouini, Adil, Najimi, Mustapha, Sokal, Etienne, Cassiman, David, Snoeys, Jan, Monshouwer, Mario, Hu, Wei-Shou, Lange, Christian, Carmeliet, Peter, Fendt, Sarah-Maria, and Verfaillie, Catherine M.

Published
2020
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7. Age-associated changes in fibrosis amount and spatial organization and its effects on human ventricular electrophysiology

Author

Perez-Zabalza, Maria, primary, Garcta-Mendtvil, Laura, additional, Mountris, Kostantinos A, additional, Smisdom, Nick, additional, Vallejo-Gil, Jose M, additional, Fresneda-Roldan, Pedro C, additional, Fananas-Mastral, Javier, additional, Matamala-Adell, Marta, additional, Sorribas-Berjon, Fernando, additional, Vazquez-Sancho, Manuel, additional, Bellido-Morales, Javier Andre, additional, Mancebon-Sierra, Francisco Javier, additional, Vaca-Nunez, Alexander Sebastian, additional, Ballester-Cuenca, Carlos, additional, Olivan-Viguera, Aida, additional, Ordovas, Laura, additional, and Pueyo, Esther, additional

Published
2021
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12. [P3-080]: AN ACADEMIC-PRIVATE PARTNERSHIP FOR THE VALIDATION OF NEW MODELS TO UNDERSTAND TAU-RELATED HYPEREXCITABILITY AND AGGREGATION USING HUMAN-INDUCED PLURIPOTENT STEM CELLS

Author

Garcia Leon, Juan Antonio, primary, Pestana, Francisco, additional, Kreir, Mohamed, additional, Shih, Pei-Yu, additional, Eggermont, Kristel, additional, Terryn, Joke, additional, Stumman, Tina Charlotte, additional, Geraerts, Martine, additional, Craig, Peter James, additional, Nuthall, Hugh norman, additional, Verheyen, An, additional, Royaux, Ines, additional, Fazal, Raheem, additional, Quiles, Ana, additional, Ordovas, Laura, additional, Bruce, Kevin, additional, Foerch, Patrik, additional, Diego Pita Almenar, Juan, additional, Ebneth, Andreas, additional, Verfaillie, Catherine, additional, and Socorro, Alfredo Cabrera, additional

Published
2017
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13. Molecular Imaging of Human Embryonic Stem Cells Stably Expressing Human PET Reporter Genes After Zinc Finger Nuclease–Mediated Genome Editing

Author

Wolfs, Esther, primary, Holvoet, Bryan, additional, Ordovas, Laura, additional, Breuls, Natacha, additional, Helsen, Nicky, additional, Schönberger, Matthias, additional, Raitano, Susanna, additional, Struys, Tom, additional, Vanbilloen, Bert, additional, Casteels, Cindy, additional, Sampaolesi, Maurilio, additional, Van Laere, Koen, additional, Lambrichts, Ivo, additional, Verfaillie, Catherine M., additional, and Deroose, Christophe M., additional

Published
2017
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14. AN ACADEMIC-PRIVATE PARTNERSHIP FOR THE VALIDATION OF NEW MODELS TO UNDERSTAND TAU-RELATED HYPEREXCITABILITY AND AGGREGATION USING HUMAN-INDUCED PLURIPOTENT STEM CELLS

Author

Garcia Leon, Juan Antonio, Pestana, Francisco, Kreir, Mohamed, Shih, Pei-Yu, Eggermont, Kristel, Terryn, Joke, Stumman, Tina Charlotte, Geraerts, Martine, Craig, Peter James, Nuthall, Hugh norman, Verheyen, An, Royaux, Ines, Fazal, Raheem, Quiles, Ana, Ordovas, Laura, Bruce, Kevin, Foerch, Patrik, Pita Almenar, Juan Diego, Ebneth, Andreas, Verfaillie, Catherine, and Socorro, Alfredo Cabrera

Published
2017
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15. Prospectively Isolated NGN3-Expressing Progenitors From Human Embryonic Stem Cells Give Rise to Pancreatic Endocrine Cells

Author

Cai, Qing, primary, Bonfanti, Paola, additional, Sambathkumar, Rangarajan, additional, Vanuytsel, Kim, additional, Vanhove, Jolien, additional, Gysemans, Conny, additional, Debiec-Rychter, Maria, additional, Raitano, Susanna, additional, Heimberg, Harry, additional, Ordovas, Laura, additional, and Verfaillie, Catherine M., additional

Published
2014
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16. Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells

Author

Roelandt, Philip, primary, Pauwelyn, Karen Ann, additional, Sancho-Bru, Pau, additional, Subramanian, Kartik, additional, Bose, Bipasha, additional, Ordovas, Laura, additional, Vanuytsel, Kim, additional, Geraerts, Martine, additional, Firpo, Meri, additional, De Vos, Rita, additional, Fevery, Johan, additional, Nevens, Frederik, additional, Hu, Wei-Shou, additional, and Verfaillie, Catherine M., additional

Published
2010
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19. Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Author

Laura García-Mendívil, María Pérez-Zabalza, Konstantinos Mountris, Sam Duwé, Nick Smisdom, Marta Pérez, Lluís Luján, Esther Wolfs, Ronald B. Driesen, José María Vallejo-Gil, Pedro Carlos Fresneda-Roldán, Javier Fañanás-Mastral, Manuel Vázquez-Sancho, Marta Matamala-Adell, Juan Fernando Sorribas-Berjón, Javier André Bellido-Morales, Francisco Javier Mancebón-Sierra, Alexánder Sebastián Vaca-Núñez, Carlos Ballester-Cuenca, Aida Oliván-Viguera, Emiliano Diez, Laura Ordovás, Esther Pueyo, Garcia-Mendivil, Laura, Perez-Zabalza, Maria, Mountris, Konstantinos, DUWE, Sam, SMISDOM, Nick, Perez, Marta, Lujan, Lluis, WOLFS, Esther, DRIESEN, Ronald, Maria Vallejo-Gil, Jose, Carlos Fresneda-Roldan, Pedro, Fananas-Mastral, Javier, Vazquez-Sancho, Manuel, Matamala-Adell, Marta, Fernando Sorribas-Berjon, Juan, Andre Bellido-Morales, Javier, Javier Mancebon-Sierra, Francisco, Sebastian Vaca-Nunez, Alexander, Ballester-Cuenca, Carlos, Olivan-Viguera, Aida, Diez, Emiliano, Ordovas, Laura, and Pueyo, Esther

Subjects
ARRHYTHMIAS, Science & Technology, Multidisciplinary, MYOCARDIAL FIBROSIS, IMAGES, Science, HEARTS, Computational bioinformatics, QUANTIFICATION, Pathophysiology, Multidisciplinary Sciences, CONDUCTION, LIPOFUSCIN, Science & Technology - Other Topics, Disease, CARDIAC FIBROSIS, MATRIX, SYSTEM
Abstract

Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. This work was supported by Ministerio de Ciencia e Innovacio´ n (Spain) (PID2019-105674RB-I00), by Gobierno de Arago´ n (LMP94_21) and (LMP128_21), by the European Research Council through grant ERC-StG 638284 and by European Social Fund and by Gobierno de Arago´ n (Reference Group BSICoS T39-20R) cofunded by FEDER 2014–2020 ‘‘Building Europe from Aragon‘‘. L.G-M was supported by a predoctoral fellowship from the Departamento de Ciencia, Universidad y Sociedad del Conocimiento from the Gobierno de Arago´ n 2016–2020 cofounded by Programa Operativo del Fondo Social Europeo Arago´ n (C150/2016), EMBO Short-Term fellowship (7710), and Ibercaja-CAI Estancias de Investigacio´ n IT18/18. Authors would like to acknowledge the Experimental Surgery Service of Aragon Health Sciences Institute (CIBA, Zaragoza, Spain), Mercazaragoza slaughterhouse (Zaragoza, Spain), and The Pink Pig slaughterhouse (Zuera, Spain) for their collaboration in the collection of young, adult, and boar tissue specimens, respectively.

Published
2022

20. Identification of 14 new single nucleotide polymorphisms in the bovine SLC27A1 gene and evaluation of their association with milk fat content.

Author

Ordovas L, Zaragoza P, Altarriba J, and Rodellar C

Subjects
Animals, Cattle, Fats metabolism, Female, Gene Expression Regulation, Genotype, Milk metabolism, Fats analysis, Fatty Acid Transport Proteins genetics, Milk chemistry, Polymorphism, Single Nucleotide genetics
Abstract

The solute carrier family 27 member 1 (SLC27A1) is an integral membrane protein involved in the transport of long-chain fatty acids across the plasma membrane. This protein has been implicated in diet-induced obesity and is thought to be important in the control of energy homeostasis. In previous reports, our group described the isolation and characterization of the bovine SLC27A1 gene. The bovine gene is organized in 13 exons spanning over more than 40 kb of genomic DNA and maps in BTA 7 where several quantitative trait loci for fat related traits have been described. Because of its key role in lipid metabolism and its genomic localization, in the present work the search for variability in the bovine SLC27A1 gene was carried out with the aim of evaluating its potential association with milk fat content in dairy cattle. By sequencing analysis of all exons and flanking regions 14 new single nucleotide polymorphisms (SNPs) were identified: 1 in the promoter, 7 in introns and 6 in exons. Allele frequencies of all the SNPs were calculated by minisequencing analysis in two groups of Holstein-Friesian animals with highest and lowest milk-fat content estimated breeding values as well as in animals of two Spanish cattle breeds, Asturiana de los Valles and Menorquina. In the conditions assayed, no significant differences between Holstein-Friesian groups were found for any of the SNPs, suggesting that the SLC27A1 gene may have a poor or null effect on milk fat content. In Asturiana and Menorquina breeds all the positions were polymorphic with the exception of SNPs 1 and 8 in which C allele was fixed in both of them.

Published
2008
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