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1. Correction: Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity: a secondary analysis of CORDIOPREV randomized controlled trial

Author

Podadera-Herreros, Alicia, Arenas-de Larriva, Antonio P., Gutierrez-Mariscal, Francisco M., Alcala-Diaz, Juan F., Ojeda-Rodriguez, Ana, Rodriguez-Cantalejo, Fernando, Cardelo, Magdalena P., Rodriguez-Cano, Diego, Torres-Peña, Jose D., Luque, Raul M., Ordovas, Jose M., Perez-Martinez, Pablo, Delgado-Lista, Javier, Lopez-Miranda, Jose, and Yubero-Serrano, Elena M.

Published
2024
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2. Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity: a secondary analysis of CORDIOPREV randomized controlled trial

Author

Podadera-Herreros, Alicia, Arenas-de Larriva, Antonio P., Gutierrez-Mariscal, Francisco M., Alcala-Diaz, Juan F., Ojeda-Rodriguez, Ana, Rodriguez-Cantalejo, Fernando, Cardelo, Magdalena P., Rodriguez-Cano, Diego, Torres-Peña, Jose D., Luque, Raul M., Ordovas, Jose M., Perez-Martinez, Pablo, Delgado-Lista, Javier, Lopez-Miranda, Jose, and Yubero-Serrano, Elena M.

Published
2024
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4. A metabolomic signature of the APOE2 allele

Author

Sebastiani, Paola, Song, Zeyuan, Ellis, Dylan, Tian, Qu, Schwaiger-Haber, Michaela, Stancliffe, Ethan, Lustgarten, Michael S, Funk, Cory C, Baloni, Priyanka, Yao, Cong-Hui, Joshi, Shakchhi, Marron, Megan M, Gurinovich, Anastasia, Li, Mengze, Leshchyk, Anastasia, Xiang, Qingyan, Andersen, Stacy L, Feitosa, Mary F, Ukraintseva, Svetlana, Soerensen, Mette, Fiehn, Oliver, Ordovas, Jose M, Haigis, Marcia, Monti, Stefano, Barzilai, Nir, Milman, Sofiya, Ferrucci, Luigi, Rappaport, Noa, Patti, Gary J, and Perls, Thomas T

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Genetics, Aging, Aged, 80 and over, Humans, Apolipoprotein E2, Polymorphism, Genetic, Alleles, Longitudinal Studies, Apolipoproteins E, Apolipoprotein E, Longevity, Metabolomics, Lipid metabolism, Clinical sciences
Abstract

With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants. This consortium includes the New England Centenarian Study, the Baltimore Longitudinal Study of Aging, the Arivale study, the Longevity Genes Project/LonGenity studies, and the Long Life Family Study. We analyzed the association between APOE genotype groups E2 (e2e2 and e2e3 genotypes, N = 544), E3 (e3e3 genotypes, N = 2299), and E4 (e3e4 and e4e4 genotypes, N = 702) with metabolite profiles in the five studies and used fixed effect meta-analysis to aggregate the results. Our meta-analysis identified a signature of 19 metabolites that are significantly associated with the E2 genotype group at FDR

Published
2023

5. Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study

Author

Rivas-Garcia, Lorenzo, Quintana-Navarro, Gracia M., Torres-Peña, Jose D., Arenas-de Larriva, Antonio P., Alcala-Díaz, Juan F., Yubero-Serrano, Elena M., Perez Caballero, Ana I., Ortiz-Morales, Ana M., Rangel-Zuñiga, Oriol Alberto, López-Moreno, Alejandro, Ordovas, Jose M., Perez-Martinez, Pablo, Lopez-Miranda, Jose, and Delgado-Lista, Javier

Published
2024
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8. Contributors

Author

Aiken, Catherine E.M., primary, Amiri, Azita, additional, Anderson, Faith L., additional, Argenson, Arthur, additional, Arita, Anna, additional, Attarian, Hrayr, additional, Berner, Alison, additional, Bhandari, Vineet, additional, Bhat, Vishwanath, additional, Bos, Angelo Jose Goncalves, additional, Bradbury, Neil A., additional, Bucher, Meghan L., additional, Burns, Jan, additional, Campesi, Ilaria, additional, Casadevall, Arturo, additional, Chiti, Hossein, additional, Christiansen, Dorte M., additional, Coad, Beth, additional, Corella, Dolores, additional, Coromilas, Ellie J., additional, de leon, Romina Garcia, additional, Devi-Chou, Virginia, additional, Dicent, Jocelyn, additional, Dorak, Mehmet Tevfik, additional, Einstein, Gillian, additional, Fajkovic, Harun, additional, Fang, Ferric C., additional, Fattore, Liana, additional, Fausto-Sterling, Anne, additional, Fazeli, Alireza, additional, Feldberg, Dov, additional, Fillingim, Roger B., additional, Franconi, Flavia, additional, Frith, Karen H., additional, Fritzen, Andreas M., additional, Fukui, Michika, additional, Galea, Liisa A.M., additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmati, Donato, additional, Giblin, Josephine, additional, Glezerman, Marek, additional, Godakumara, Kasun, additional, Gram, Sydney, additional, Guillamon, Antonio, additional, Haga, Susanne B., additional, Hennessey, Jessica A., additional, Hihara, Masakatsu, additional, Holt, William V., additional, Hufnagel, Antonia, additional, Iwaguro, Hideki, additional, Jamialahmadi, Tannaz, additional, Joel, Daphna, additional, Jovanov, Emil, additional, Kakudo, Natsuko, additional, Kiens, Bente, additional, Kim, Jin Kyung, additional, Kirchengast, Sylvia, additional, Kochav, Stephanie M., additional, Kodithuwakku, Suranga P., additional, Kok, L.M., additional, Koopman, Peter, additional, Krut, Zoe, additional, Kuro, Atsuyuki, additional, Kuroda, Ryosuke, additional, Kushida, Satoshi, additional, Lai, Yunjia, additional, Lee, Bonnie H., additional, Lleo, Ana, additional, Lundsgaard, Anne-Marie, additional, Maggi, Adriana C., additional, Matsushita, Satoshi, additional, McCarthy, Margaret M., additional, Melloni, Alice, additional, Meloni, Maurizio, additional, Miller, Gary W., additional, Mishra, Suresh, additional, Mitsui, Toshihito, additional, Mizuno, Hiroshi, additional, Nelissen, R.G.H.H., additional, Nickl, Petr, additional, Nomura, Tatsuya, additional, Oertelt-Prigione, Sabine, additional, Oliveira-Zumda, Gabriela Guimaraes, additional, Ordovas, Jose M., additional, Parsamanesh, Negin, additional, Pelled, Gadi, additional, Puiu, Andrei A., additional, Rajah, M. Natasha, additional, Reddy, Doodipala Samba, additional, Reiner, Željko, additional, Sahebkar, Amirhossein, additional, Saita, Yoshitomo, additional, Sánchez-Serrano, Ibis, additional, Sari Motlagh, Reza, additional, Savic, Ivanka, additional, Schmidinger, Manuela, additional, Schmidt, Caleb M., additional, Schmidt, Michael A., additional, Sedlacek, Radislav, additional, Serani, Angelo, additional, Shaib, Fidaa, additional, Shariat, Shahrokh F., additional, Singh, Keshav K., additional, Sobajima, Satoshi, additional, Sokolowski, Dustin J., additional, Sokolowski, Marla B., additional, Sun, Simón(e) D., additional, Sun, Zhongxin, additional, Sung, Jihyun, additional, Syding, Linn Amanda, additional, Taneja, Veena, additional, Tautz, Diethard, additional, Thurston, Lisa M., additional, Tierney, Siobhan, additional, Tisato, Veronica, additional, Tobita, Morikuni, additional, Tollkuhn, Jessica, additional, Tsubosaka, Masanori, additional, Tucci, Valter, additional, Uribe, Carme, additional, Van Noort, A., additional, Votinov, Mikhail, additional, Walsh, Reubs J., additional, Wan, Elaine Y., additional, and Zubiaurre-Elorza, Leire, additional

Published
2023
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10. Association between telomere length and intima-media thickness of both common carotid arteries in patients with coronary heart disease: From the CORDIOPREV randomized controlled trial

Author

Ojeda-Rodriguez, Ana, Alcala-Diaz, Juan F., Rangel-Zuñiga, Oriol Alberto, Arenas-de Larriva, Antonio Pablo, Gutierrez-Mariscal, Francisco M., Gómez-Luna, Purificación, Torres-Peña, Jose D., Garcia-Rios, Antonio, Romero-Cabrera, Juan L., Malagon, Maria M., Perez-Martinez, Pablo, Ordovas, Jose M., Delgado-Lista, Javier, Yubero-Serrano, Elena M., and Lopez-Miranda, Jose

Published
2023
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11. Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial

Author

Bermingham, Kate M., primary, Linenberg, Inbar, additional, Polidori, Lorenzo, additional, Asnicar, Francesco, additional, Arrè, Alberto, additional, Wolf, Jonathan, additional, Badri, Fatema, additional, Bernard, Hannah, additional, Capdevila, Joan, additional, Bulsiewicz, William J., additional, Gardner, Christopher D., additional, Ordovas, Jose M., additional, Davies, Richard, additional, Hadjigeorgiou, George, additional, Hall, Wendy L., additional, Delahanty, Linda M., additional, Valdes, Ana M., additional, Segata, Nicola, additional, Spector, Tim D., additional, and Berry, Sarah E., additional

Published
2024
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12. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Author

Díez-Ricote, Laura, San-Cristobal, Rodrigo, Concejo, M José, Martínez-González, Miguel Á, Corella, Dolores, Salas-Salvadó, Jordi, Goday, Albert, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A, Martín Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Ros, Emilio, Vázquez-Ruiz, Zenaida, Ortega-Azorín, Carolina, García-Gavilán, Jesús F, Malcampo, Mireia, Martínez-Urbistondo, Diego, Tojal-Sierra, Lucas, García Rodríguez, Antonio, Gómez-Bellvert, Nuria, Chaplin, Alice, García-Ríos, Antonio, Bernal-López, Rosa M, Santos-Lozano, José M, Basterra-Gortari, Javier, Sorlí, José V, Murphy, Michelle, Gasulla, Griselda, Micó, Víctor, Salaverria-Lete, Itziar, Goñi Ochandorena, Estibaliz, Babio, Nancy, Herraiz, Xavier, Ordovás, José M, and Daimiel, Lidia

Published
2022
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14. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Author

Alcala-Diaz, Juan F, Almaden Peña, Yolanda, Aranda, Enrique, Arenas de Larriva, Antonio P, Badimon, Lina, Badimon, Juan J, Blanco-Molina, Angeles, Blanco-Rojo, Ruth, Bolivar-Muñoz, Julia, Caballero-Villarraso, Javier, Camargo, Antonio, Chica, Javier, Corina, Andreea, Criado-Garcia, Juan, Cruz-Teno, Cristina, Daponte-Codina, Antonio, de Teresa Galvan, Eduardo, Delgado-Casado, Nieves, Delgado-Lista, Javier, Estruch, Ramon, Fernandez, Juan M, Fernandez-Gandara, Carolina, Fuentes-Jimenez, Francisco, Garcia-Carpintero Fernandez-Pacheco, Sonia, Garcia-Rios, Antonio, Gomez-Delgado, Francisco, Gomez-Garduño, Angela, Gomez-Luna, Purificacion, Gomez-Luna, Maria J, Gonzalez-Guardia, Lorena, Gonzalez-Requero, Ana I., Gutierrez-Mariscal, Francisco M, Haro-Mariscal, Carmen M, Jimenez-Lucena, Rosa, Jimenez-Morales, Ana I., Leon-Acuña, Ana, Lopez-Miranda, Jose, Lopez-Segura, Fernando, Marin-Hinojosa, Carmen, Meneses Alvarez, Maria E, Mesa-Luna, Dolores, Moya-Garrido, Maria N, Muñoz-Carvajal, Ignacio, Navarro-Martos, Vanessa, Ochoa, Juan J, Ordovas, Jose M, Ortiz-Minuesa, Juan A, Ortiz-Morales, Ana M, Pan, Manuel, Peña-Orihuela, Patricia, Perez-Caballero, Ana I, Perez-Corral, Isabel, Perez-Jimenez, Francisco, Perez-Martinez, Pablo, Pi-Sunyer, Francesc X, Quintana-Navarro, Gracia M, Ramirez-Lara, Irene, Rangel-Zuñiga, Oriol A, Rodriguez-Artalejo, Fernando, Rodriguez-Cantalejo, Fernando, Romero, Miguel A, Roncero-Ramos, Irene, Ruano-Ruiz, Juan A., Ruiz de Castroviejo, Joaquin, Sanchez-Villegas, Pablo, Suarez de Lezo, Jose, Suarez de Lezo, Javier, Torres-Peña, Jose D, Vals-Delgado, Cristina, Valverde, Roberto, Visioli, Francisco, Yubero-Serrano, Elena M, Fuentes, Francisco, and Gonzalez-Requero, Ana I

Published
2022
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17. Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study

Author

Romero-Cabrera, Juan Luis, Garaulet, Marta, Jimenez-Torres, Jose, Alcala-Diaz, Juan F., Quintana Navarro, Gracia M., Martin-Piedra, Laura, Torres-Peña, Jose David, Rodriguez-Cantalejo, Fernando, Rangel-Zuñiga, Oriol Alberto, Yubero-Serrano, Elena Maria, Luque, Raul M., Ordovas, Jose M., Lopez-Miranda, Jose, Pérez-Martínez, Pablo, and García-Rios, Antonio

Published
2022
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18. Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial

Author

Podadera-Herreros, Alicia, Alcala-Diaz, Juan F., Gutierrez-Mariscal, Francisco M., Jimenez-Torres, Jose, Cruz-Ares, Silvia de la, Arenas-de Larriva, Antonio P., Cardelo, Magdalena P., Torres-Peña, Jose D., Luque, Raul M., Ordovas, Jose M., Delgado-Lista, Javier, Lopez-Miranda, Jose, and Yubero-Serrano, Elena M.

Published
2022
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19. Acylcarnitines are associated with lower depressive symptomatology in a mainland puerto rican cohort.

Author

Palacios, Natalia, Bhupathiraju, Shilpa N., Kelly, Rachel S., Lee, Jong Soo, Ordovas, Jose M., and Tucker, Katherine L.

Subjects
CENTER for Epidemiologic Studies Depression Scale, PUERTO Ricans, GENE regulatory networks, OLDER people, MULTIPLE comparisons (Statistics)
Abstract

Introduction: Recent studies have implicated acetyl-l-carnitine as well as other acylcarnitines in depression. To our knowledge, no untargeted metabolomics studies have been conducted among US mainland Puerto Ricans. Objectives: We conducted untargeted metabolomic profiling on plasma from 736 participants of the Boston Puerto Rican Health Study. Methods: Using Weighted Gene Co-expression Network Analysis, we identified metabolite modules associated with depressive symptomatology, assessed via the Center for Epidemiologic Studies Depression scale. We identified metabolites contributing to these modules and assessed the relationship between these metabolites and depressive symptomatology. Results: 621 annotated metabolites clustered into eight metabolite modules, of which one, the acylcarnitine module, was significantly inversely associated with depressive symptomatology (β = − 27.7 (95% CI (− 54.5—0.8); p = 0.043). Several metabolite hub features in the acylcarnitine module were significantly associated with depressive symptomatology, after correction for multiple comparisons. Conclusions: In this untargeted plasma metabolomics study among mainland Puerto Rican older adults, acylcarnitines, as a metabolite module were inversely associated with depressive symptomatology. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

Author

Huang, Tao, Ding, Ming, Bergholdt Helle, KM, Wang, Tiange, Heianza, Yoriko, Sun, Dianjianyi, Frazier-Wood Alexis, C, Aslibekyan, Stella, North Kari, E, Voortman, Trudy, Graff, Mariaelisa, Smith Caren, E, Lai, Chao-Qiang, Varbo, Anette, Lemaitre, Rozenn N, de Jonge, M Ester AL, Fumeron, Frédéric, Corella, Dolores, Wang, Carol A, Tjønneland, Anne, Overvad, Kim, Sørensen, Thorkild IA, Feitosa, Mary F, Wojczynski, Mary K, Kähönen, Mika, Renström, Frida, Psaty, Bruce M, Siscovick, David S, Barroso, Inês, Johansson, Ingegerd, Hernandez, Dena, Ferrucci, Luigi, Bandinelli, Stefania, Linneberg, Allan, Zillikens, M Carola, Sandholt, Camilla Helene, Pedersen, Oluf, Hansen, Torben, Schulz, Christina-Alexandra, Sonestedt, Emily, Orho-Melander, Marju, Chen, Tzu-An, Rotter, Jerome I, Allison, Mathew A, Rich, Stephen S, Sorlí, Jose V, Coltell, Oscar, Pennell, Craig E, Eastwood, Peter, Hofman, Albert, Uitterlinden, Andre G, van Rooij, Frank JA, Chu, Audrey Y, Rose, Lynda M, Ridker, Paul M, Viikari, Jorma, Raitakari, Olli, Lehtimäki, Terho, Mikkilä, Vera, Willett, Walter C, Wang, Yujie, Tucker, Katherine L, Ordovas, Jose M, Kilpeläinen, Tuomas O, Province, Michael A, Franks, Paul W, Arnett, Donna K, Tanaka, Toshiko, Toft, Ulla, Ericson, Ulrika, Franco, Oscar H, Mozaffarian, Dariush, Hu, Frank B, Chasman, Daniel I, Nordestgaard, Børge G, Ellervik, Christina, and Qi, Lu

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Genetics, Adult, Body Mass Index, Body Weight, Cross-Sectional Studies, Dairy Products, Genotype, Humans, Mendelian Randomization Analysis, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Prospective Studies, Mendelian Randomization of Dairy Consumption Working Group, Medical Biotechnology, Medical Biochemistry and Metabolomics, Clinical Sciences, General Clinical Medicine, Clinical sciences, Medical biochemistry and metabolomics
Abstract

BackgroundAssociations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.MethodsWe performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies.ResultsHigher dairy intake was associated with higher BMI (β = 0.03 kg/m2 per serving/day; 95% CI, 0.00-0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake (P = 3.15 × 10-12) and 0.12 (95% CI, 0.06-0.17) kg/m2 higher BMI (P = 2.11 × 10-5). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m2 per serving/day; 95% CI, 0.27-0.92; P = 3.0 × 10-4).ConclusionsThe present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.

Published
2018

23. Beta cell functionality and hepatic insulin resistance are major contributors to type 2 diabetes remission and starting pharmacological therapy: from CORDIOPREV randomized controlled trial

Author

Roncero-Ramos, Irene, Gutierrez-Mariscal, Francisco M., Gomez-Delgado, Francisco, Villasanta-Gonzalez, Alejandro, Torres-Peña, Jose D., Cruz-Ares, Silvia De La, Rangel-Zuñiga, Oriol A., Luque, Raul M., Ordovas, Jose M., Delgado-Lista, Javier, Perez-Martinez, Pablo, Camargo, Antonio, Alcalá-Diaz, Juan F., and Lopez-Miranda, Jose

Published
2021
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26. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Author

Zheng, Yan, Huang, Tao, Wang, Tiange, Mei, Zhendong, Sun, Zhonghan, Zhang, Tao, Ellervik, Christina, Chai, Jin-Fang, Sim, Xueling, van Dam, Rob M., Tai, E-Shyong, Koh, Woon-Puay, Dorajoo, Rajkumar, Saw, Seang-Mei, Sabanayagam, Charumathi, Wong, Tien Yin, Gupta, Preeti, Rossing, Peter, Ahluwalia, Tarunveer S., Vinding, Rebecca K., Bisgaard, Hans, Bønnelykke, Klaus, Wang, Yujie, Graff, Mariaelisa, Voortman, Trudy, van Rooij, Frank J. A., Hofman, Albert, van Heemst, Diana, Noordam, Raymond, Estampador, Angela C., Varga, Tibor V., Enzenbach, Cornelia, Scholz, Markus, Thiery, Joachim, Burkhardt, Ralph, Orho-Melander, Marju, Schulz, Christina-Alexandra, Ericson, Ulrika, Sonestedt, Emily, Kubo, Michiaki, Akiyama, Masato, Zhou, Ang, Kilpeläinen, Tuomas O., Hansen, Torben, Kleber, Marcus E., Delgado, Graciela, McCarthy, Mark, Lemaitre, Rozenn N., Felix, Janine F., Jaddoe, Vincent W. V., Wu, Ying, Mohlke, Karen L., Lehtimäki, Terho, Wang, Carol A., Pennell, Craig E., Schunkert, Heribert, Kessler, Thorsten, Zeng, Lingyao, Willenborg, Christina, Peters, Annette, Lieb, Wolfgang, Grote, Veit, Rzehak, Peter, Koletzko, Berthold, Erdmann, Jeanette, Munz, Matthias, Wu, Tangchun, He, Meian, Yu, Caizheng, Lecoeur, Cécile, Froguel, Philippe, Corella, Dolores, Moreno, Luis A., Lai, Chao-Qiang, Pitkänen, Niina, Boreham, Colin A., Ridker, Paul M., Rosendaal, Frits R., de Mutsert, Renée, Power, Chris, Paternoster, Lavinia, Sørensen, Thorkild I. A., Tjønneland, Anne, Overvad, Kim, Djousse, Luc, Rivadeneira, Fernando, Lee, Nanette R., Raitakari, Olli T., Kähönen, Mika, Viikari, Jorma, Langhendries, Jean-Paul, Escribano, Joaquin, Verduci, Elvira, Dedoussis, George, König, Inke, Balkau, Beverley, Coltell, Oscar, Dallongeville, Jean, Meirhaeghe, Aline, Amouyel, Philippe, Gottrand, Frédéric, Pahkala, Katja, Niinikoski, Harri, Hyppönen, Elina, März, Winfried, Mackey, David A., Gruszfeld, Dariusz, Tucker, Katherine L., Fumeron, Frédéric, Estruch, Ramon, Ordovas, Jose M., Arnett, Donna K., Mook-Kanamori, Dennis O., Mozaffarian, Dariush, Psaty, Bruce M., North, Kari E., Chasman, Daniel I., and Qi, Lu

Published
2020

28. Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA)

Author

Wang, Zhe, Manichukal, Ani, Goff, David C, Mora, Samia, Ordovas, Jose M, Pajewski, Nicholas M, Post, Wendy S, Rotter, Jerome I, Sale, Michele M, Santorico, Stephanie A, Siscovick, David, Tsai, Michael Y, Arnett, Donna K, Rich, Stephen, and Frazier-Wood, Alexis C

Subjects
Biological Sciences, Genetics, Atherosclerosis, Aging, Human Genome, Cardiovascular, Aged, Aged, 80 and over, Ethnicity, Female, Humans, Lipoproteins, Male, Middle Aged, Polymorphism, Single Nucleotide, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract

A recent genome-wide association study associated 62 single nucleotide polymorphisms (SNPs) from 43 genomic loci, with fasting lipoprotein subfractions in European-Americans (EAs) at genome-wide levels of significance across three independent samples. Whether these associations are consistent across ethnicities with a non-European ancestry is unknown. We analyzed 15 lipoprotein subfraction measures, on 1677 African-Americans (AAs), 1450 Hispanic-Americans (HAs), and 775 Chinese-Americans (CHN) participating in the multi-ethnic study of atherosclerosis (MESA). Genome-wide data were obtained using the Affymetrix 6.0 and Illumina HumanOmni chips. Linear regression models between genetic variables and lipoprotein subfractions were adjusted for age, gender, body mass index, smoking, study center, and genetic ancestry (based on principal components), and additionally adjusted for Mexican/Non-Mexican status in HAs. A false discovery rate correction was applied separately within the results for each ethnicity to correct for multiple testing. Power calculations revealed that we did not have the power for SNP-based measures of association, so we analyzed phenotype-specific genetic risk scores (GRSs), constructed as in the original genome-wide analysis. We successfully replicated all 15 GRS-lipoprotein associations in 2527 EAs. Among the 15 significant GRS-lipoprotein associations in EAs, 11 were significant in AAs, 13 in HAs, and 1 in CHNs. Further analyses revealed that ethnicity differences could not be explained by differences in linkage disequilibrium, lipid lowering drugs, diabetes, or gender. Our study emphasizes the importance of ethnicity (here indexing genetic ancestry) in genetic risk for CVD and highlights the need to identify ethnicity-specific genetic variants associated with CVD risk.

Published
2017

30. Telomere Maintenance Is Associated with Type 2 Diabetes Remission in Response to a Long-Term Dietary Intervention without Non-Weight Loss in Patients with Coronary Heart Disease: From the CORDIOPREV Randomized Controlled Trial

Author

Ojeda-Rodriguez, Ana, primary, Alcala-Diaz, Juan F., additional, Rangel-Zuñiga, Oriol Alberto, additional, Arenas-de Larriva, Antonio P., additional, Gutierrez-Mariscal, Francisco M., additional, Torres-Peña, Jose D., additional, Mora-Ortiz, Marina, additional, Romero-Cabrera, Juan L., additional, Luque, Raul M., additional, Ordovas, Jose M., additional, Perez-Martinez, Pablo, additional, Delgado-Lista, Javier, additional, Yubero-Serrano, Elena M., additional, and Lopez-Miranda, Jose, additional

Published
2024
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31. A genome-wide study of lipid response to fenofibrate in Caucasians

Author

Irvin, Marguerite R, Rotroff, Daniel M, Aslibekyan, Stella, Zhi, Degui, Hidalgo, Bertha, Motsinger-Reif, Alison, Marvel, Skylar, Srinivasasainagendra, Vinodh, Claas, Steven A, Buse, John B, Straka, Robert J, Ordovas, Jose M, Borecki, Ingrid B, Guo, Xiuqing, Chen, Ida YD, Rotter, Jerome I, Wagner, Michael J, and Arnett, Donna K

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Atherosclerosis, Human Genome, Cardiovascular, Clinical Trials as Topic, Female, Fenofibrate, Genetic Markers, Genome-Wide Association Study, Genotype, Humans, Hypertriglyceridemia, Hypolipidemic Agents, Lipid Metabolism, Lipids, Male, Meta-Analysis as Topic, Middle Aged, Outcome Assessment, Health Care, White People, cholesterol, dyslipidemia, fenofibrate, genome-wide association study, lipid, lipoprotein, triglyceride, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

BackgroundFibrates are commonly prescribed for hypertriglyceridemia, but they also lower LDL cholesterol and increase HDL cholesterol. Large interindividual variations in lipid response suggest that some patients may benefit more than others and genetic studies could help identify such patients.MethodsWe carried out the first genome-wide association study of lipid response to fenofibrate using data from two well-characterized clinical trials: the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study. Genome-wide association study data from both studies were imputed to the 1000 Genomes CEU reference panel (phase 1). Lipid response was modeled as the log ratio of the post-treatment lipid level to the pretreatment level. Linear mixed models (GOLDN, N=813 from 173 families) and linear regression models (ACCORD, N=781) adjusted for pretreatment lipid level, demographic variables, clinical covariates, and ancestry were used to evaluate the association of genetic markers with lipid response. Among Caucasians, the results were combined using inverse-variance weighted fixed-effects meta-analyses. The main findings from the meta-analyses were examined in other ethnic groups from the HyperTG study (N=267 Hispanics) and ACCORD (N=83 Hispanics, 138 African Americans).ResultsA known lipid locus harboring the pre-B-cell leukemia homeobox 4 (PBX4) gene on chromosome 19 is important for LDL cholesterol response to fenofibrate (smallest P=1.5×10). The main results replicated with nominal statistical significance in Hispanics from ACCORD (P

Published
2016

32. Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk

Author

Coltell, Oscar, primary, Asensio, Eva M., additional, Sorlí, José V., additional, Ortega-Azorín, Carolina, additional, Fernández-Carrión, Rebeca, additional, Pascual, Eva C., additional, Barragán, Rocío, additional, González, José I., additional, Estruch, Ramon, additional, Alzate, Juan F., additional, Pérez-Fidalgo, Alejandro, additional, Portolés, Olga, additional, Ordovas, Jose M., additional, and Corella, Dolores, additional

Published
2023
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33. Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study

Author

Rivas-Garcia, Lorenzo, primary, Quintana-Navarro, Gracia M., additional, Torres-Peña, Jose D., additional, Arenas-de Larriva, Antonio P., additional, Alcala-Díaz, Juan F., additional, Yubero-Serrano, Elena M., additional, Perez Caballero, Ana I., additional, Ortiz-Morales, Ana M., additional, Rangel-Zuñiga, Oriol Alberto, additional, López-Moreno, Alejandro, additional, Ordovas, Jose M., additional, Perez-Martinez, Pablo, additional, Lopez-Miranda, Jose, additional, and Delgado-Lista, Javier, additional

Published
2023
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35. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians 1 , 2

Author

Fretts, Amanda M, Follis, Jack L, Nettleton, Jennifer A, Lemaitre, Rozenn N, Ngwa, Julius S, Wojczynski, Mary K, Kalafati, Ioanna Panagiota, Varga, Tibor V, Frazier-Wood, Alexis C, Houston, Denise K, Lahti, Jari, Ericson, Ulrika, van den Hooven, Edith H, Mikkilä, Vera, Kiefte-de Jong, Jessica C, Mozaffarian, Dariush, Rice, Kenneth, Renström, Frida, North, Kari E, McKeown, Nicola M, Feitosa, Mary F, Kanoni, Stavroula, Smith, Caren E, Garcia, Melissa E, Tiainen, Anna-Maija, Sonestedt, Emily, Manichaikul, Ani, van Rooij, Frank JA, Dimitriou, Maria, Raitakari, Olli, Pankow, James S, Djoussé, Luc, Province, Michael A, Hu, Frank B, Lai, Chao-Qiang, Keller, Margaux F, Perälä, Mia-Maria, Rotter, Jerome I, Hofman, Albert, Graff, Misa, Kähönen, Mika, Mukamal, Kenneth, Johansson, Ingegerd, Ordovas, Jose M, Liu, Yongmei, Männistö, Satu, Uitterlinden, André G, Deloukas, Panos, Seppälä, Ilkka, Psaty, Bruce M, Cupples, L Adrienne, Borecki, Ingrid B, Franks, Paul W, Arnett, Donna K, Nalls, Mike A, Eriksson, Johan G, Orho-Melander, Marju, Franco, Oscar H, Lehtimäki, Terho, Dedoussis, George V, Meigs, James B, and Siscovick, David S

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Diabetes, Genetics, Aging, Cardiovascular, Nutrition, Metabolic and endocrine, Blood Glucose, Cohort Studies, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hyperglycemia, Hyperinsulinism, Insulin, Insulin Resistance, Insulin Secretion, Insulin-Secreting Cells, Meat, Meat Products, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, diet, gene–diet interaction, glucose, insulin, meat intake, meta-analysis, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

BackgroundRecent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown.ObjectiveWe investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus.DesignFourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined 1) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations.ResultsProcessed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-ln-pmol/L (95% CI: 0.035, 0.063-ln-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance.ConclusionThe association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms. Six of the participating studies are registered at clinicaltrials.gov as NCT0000513 (Atherosclerosis Risk in Communities), NCT00149435 (Cardiovascular Health Study), NCT00005136 (Family Heart Study), NCT00005121 (Framingham Heart Study), NCT00083369 (Genetics of Lipid Lowering Drugs and Diet Network), and NCT00005487 (Multi-Ethnic Study of Atherosclerosis).

Published
2015

36. Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study

Author

Yubero-Serrano, Elena M., Alcalá-Diaz, Juan F., Gutierrez-Mariscal, Francisco M., Arenas-de Larriva, Antonio P., Peña-Orihuela, Patricia J., Blanco-Rojo, Ruth, Martinez-Botas, Javier, Torres-Peña, Jose D., Perez-Martinez, Pablo, Ordovas, Jose M., Delgado-Lista, Javier, Gómez-Coronado, Diego, and Lopez-Miranda, Jose

Published
2021
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37. Correction to: Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study

Author

Yubero-Serrano, Elena M., Alcalá-Diaz, Juan F., Gutierrez-Mariscal, Francisco M., Arenas-de Larriva, Antonio P., Peña-Orihuela, Patricia J., Blanco-Rojo, Ruth, Martinez-Botas, Javier, Torres-Peña, Jose D., Perez-Martinez, Pablo, Ordovas, Jose M., Delgado-Lista, Javier, Gómez-Coronado, Diego, and Lopez-Miranda, Jose

Published
2021
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39. Human postprandial responses to food and potential for precision nutrition

Author

Berry, Sarah E., Valdes, Ana M., Drew, David A., Asnicar, Francesco, Mazidi, Mohsen, Wolf, Jonathan, Capdevila, Joan, Hadjigeorgiou, George, Davies, Richard, Al Khatib, Haya, Bonnett, Christopher, Ganesh, Sajaysurya, Bakker, Elco, Hart, Deborah, Mangino, Massimo, Merino, Jordi, Linenberg, Inbar, Wyatt, Patrick, Ordovas, Jose M., Gardner, Christopher D., Delahanty, Linda M., Chan, Andrew T., Segata, Nicola, Franks, Paul W., and Spector, Tim D.

Published
2020
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42. Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

Author

Peloso, Gina M, Auer, Paul L, Bis, Joshua C, Voorman, Arend, Morrison, Alanna C, Stitziel, Nathan O, Brody, Jennifer A, Khetarpal, Sumeet A, Crosby, Jacy R, Fornage, Myriam, Isaacs, Aaron, Jakobsdottir, Johanna, Feitosa, Mary F, Davies, Gail, Huffman, Jennifer E, Manichaikul, Ani, Davis, Brian, Lohman, Kurt, Joon, Aron Y, Smith, Albert V, Grove, Megan L, Zanoni, Paolo, Redon, Valeska, Demissie, Serkalem, Lawson, Kim, Peters, Ulrike, Carlson, Christopher, Jackson, Rebecca D, Ryckman, Kelli K, Mackey, Rachel H, Robinson, Jennifer G, Siscovick, David S, Schreiner, Pamela J, Mychaleckyj, Josyf C, Pankow, James S, Hofman, Albert, Uitterlinden, Andre G, Harris, Tamara B, Taylor, Kent D, Stafford, Jeanette M, Reynolds, Lindsay M, Marioni, Riccardo E, Dehghan, Abbas, Franco, Oscar H, Patel, Aniruddh P, Lu, Yingchang, Hindy, George, Gottesman, Omri, Bottinger, Erwin P, Melander, Olle, Orho-Melander, Marju, Loos, Ruth JF, Duga, Stefano, Merlini, Piera Angelica, Farrall, Martin, Goel, Anuj, Asselta, Rosanna, Girelli, Domenico, Martinelli, Nicola, Shah, Svati H, Kraus, William E, Li, Mingyao, Rader, Daniel J, Reilly, Muredach P, McPherson, Ruth, Watkins, Hugh, Ardissino, Diego, Project, NHLBI GO Exome Sequencing, Zhang, Qunyuan, Wang, Judy, Tsai, Michael Y, Taylor, Herman A, Correa, Adolfo, Griswold, Michael E, Lange, Leslie A, Starr, John M, Rudan, Igor, Eiriksdottir, Gudny, Launer, Lenore J, Ordovas, Jose M, Levy, Daniel, Chen, Y-D Ida, Reiner, Alexander P, Hayward, Caroline, Polasek, Ozren, Deary, Ian J, Borecki, Ingrid B, Liu, Yongmei, Gudnason, Vilmundur, Wilson, James G, van Duijn, Cornelia M, Kooperberg, Charles, Rich, Stephen S, Psaty, Bruce M, Rotter, Jerome I, O’Donnell, Christopher J, Rice, Kenneth, Boerwinkle, Eric, Kathiresan, Sekar, and Cupples, L Adrienne

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Heart Disease - Coronary Heart Disease, Human Genome, Cardiovascular, Heart Disease, Atherosclerosis, Aetiology, 2.1 Biological and endogenous factors, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Adult, Aged, Alleles, Animals, Black People, Cholesterol, HDL, Cholesterol, LDL, Cohort Studies, Coronary Disease, Female, Gene Frequency, Genetic Association Studies, Genetic Code, Genetic Variation, Humans, Linear Models, Male, Mice, Mice, Inbred C57BL, Microtubule-Associated Proteins, Middle Aged, Phenotype, Sequence Analysis, DNA, Subtilisins, Triglycerides, White People, NHLBI GO Exome Sequencing Project, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the "Exome Array" to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121*], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.

Published
2014

44. Contributors

Author

Abete, Itziar, primary, Agirre, Xabier, additional, Ahlgren, Jennie, additional, Alkorta-Aranburu, Gorka, additional, Aller, Rocío, additional, Andres-Lacueva, Cristina, additional, Antonio de Luis, Daniel, additional, Babino, Darwin, additional, Bar-El Dadon, Shimrit, additional, Bonet, Maria Luisa, additional, Bordoni, Laura, additional, Borel, Patrick, additional, Bosch, Annet M., additional, Brown, Steven, additional, Busso, Dolores, additional, Calabriso, Nadia, additional, Capurso, Antonio, additional, Capurso, Cristiano, additional, Cariello, Marica, additional, Carluccio, Maria Annunziata, additional, Casas-Agustench, Patricia, additional, Cheatham, Carol L., additional, Chirita-Emandi, Adela, additional, Chittoor, Geetha, additional, Choi, Myung-Sook, additional, Choi, Sang-Woon, additional, Cordero, Paul, additional, Corrales, Fernando J., additional, Cortés, Víctor, additional, Cross, Nicholas C.P., additional, Crujeiras, Ana B., additional, Curi, Rui, additional, De Caterina, Raffaele, additional, de Lorenzo, David, additional, Desmarchelier, Charles, additional, Dong, Olivia, additional, Estruch, Ramón, additional, Ezponda, Teresa, additional, Fenech, Michael, additional, Ferguson, Lynnette R., additional, Fischer, Karina, additional, Fontana, Luigi, additional, Friso, Simonetta, additional, Gabbianelli, Rosita, additional, Garaulet, Marat, additional, Garcia-Irigoyen, Oihane, additional, Gil, Angel, additional, Gómez-Abellán, Purificación, additional, Görman, Ulf, additional, Harris, William S., additional, Hernandez-Vazquez, Alain de J., additional, Hugenholtz, Paul, additional, Hyde, Lara K., additional, Ibáñez, Clara, additional, Izaola, Olatz, additional, Jones, Peter J.H., additional, Kirwan, Richard, additional, Kohlmeier, Martin, additional, Krupenko, Natalia I., additional, Kwon, Eun-Young, additional, Lamming, Dudley W., additional, Lamuela-Raventos, Rosa M., additional, Langin, Dominique, additional, Langley-Evans, Simon, additional, Lira do Amaral, Cátia, additional, Lopez-Minguez, Jesus, additional, Madonna, Rosalinda, additional, Mansego, Maria L., additional, Marotz, Clarisse, additional, Martinez, J. Alfredo, additional, Massaro, Marika, additional, McRitchie, Susan, additional, Mesmar, Bayan, additional, Milagro, Fermín I., additional, Moreno-Aliaga, María J., additional, Moreno-Indias, Isabel, additional, Moschetta, Antonio, additional, Navas-Carretero, Santiago, additional, Niculescu, Mihai, additional, Nordström, Karin, additional, Novo, Francisco J., additional, Oben, Jude A., additional, Odriozola, Leticia, additional, Ordovas, Jose M., additional, Palou, Andreu, additional, Parslow, Virginia R., additional, Pathmasiri, Wimal, additional, Pérez-Castrillón, José Luis, additional, Pérusse, Louis, additional, Piccinin, Elena, additional, Plaza-Diaz, Julio, additional, Prósper, Felipe, additional, Qi, Lu, additional, Ralston, Jessica C., additional, Ramírez de Molina, Ana, additional, Rasti, George, additional, Reifen, Ram, additional, Renda, Giulia, additional, Riancho, José A., additional, Riancho del Moral, José Antonio, additional, Rivadeneira, Fernando, additional, Roche, Helen M., additional, Ruiz-Mambrilla, Marta, additional, Ruiz-Ojeda, Francisco Javier, additional, Salas-Pérez, Francisca, additional, San-Cristobal, Rodrigo, additional, Santander, Nicolás, additional, Santos, José L., additional, Saupe, Jörg, additional, Scoditti, Egeria, additional, Serhan, Charles N., additional, Simonet, Nicolas G., additional, Simopoulos, Artemis P., additional, Steinle, Nanette, additional, Sumner, Susan C.J., additional, Tinahones, Francisco J., additional, Vaquero, Alejandro, additional, Vazquez-Vidal, Itzel, additional, Velazquez-Arellano, Antonio, additional, Viguerie, Nathalie, additional, Vinciguerra, Manlio, additional, Visioli, Francesco, additional, Vizmanos, José L., additional, von Lintig, Johannes, additional, Voruganti, Venkata Saroja, additional, Wanders, Ronald J.A., additional, Wang, Tiange, additional, Wiltshire, Tim, additional, Yu, Deyang, additional, Zarrinpar, Amir, additional, Zeisel, Steven H., additional, and Zulet, Maria Angeles, additional

Published
2020
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46. Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet

Author

Corella, Dolores, Ramírez-Sabio, Judith B., Coltell, Oscar, Ortega-Azorín, Carolina, Estruch, Ramón, Martínez-González, Miguel A., Salas-Salvadó, Jordi, Sorlí, José V., Castañer, Olga, Arós, Fernando, Garcia-Corte, Franscisco J., Serra-Majem, Lluís, Gómez-Gracia, Enrique, Fiol, Miquel, Pintó, Xavier, Saez, Guillermo T., Toledo, Estefanía, Basora, Josep, Fitó, Montserrat, Cofán, Montserrat, Ros, Emilio, and Ordovas, Jose M.

Published
2018
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47. Mediterranean diet improves endothelial function in patients with diabetes and prediabetes: A report from the CORDIOPREV study

Author

Torres-Peña, Jose D., Garcia-Rios, Antonio, Delgado-Casado, Nieves, Gomez-Luna, Purificacion, Alcala-Diaz, Juan F., Yubero-Serrano, Elena M., Gomez-Delgado, Francisco, Leon-Acuña, Ana, Lopez-Moreno, Javier, Camargo, Antonio, Tinahones, Francisco J., Delgado-Lista, Javier, Ordovas, Jose M., Perez-Martinez, Pablo, and Lopez-Miranda, Jose

Published
2018
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48. Genome-wide association of body fat distribution in African ancestry populations suggests new loci.

Author

Liu, Ching-Ti, Monda, Keri L, Taylor, Kira C, Lange, Leslie, Demerath, Ellen W, Palmas, Walter, Wojczynski, Mary K, Ellis, Jaclyn C, Vitolins, Mara Z, Liu, Simin, Papanicolaou, George J, Irvin, Marguerite R, Xue, Luting, Griffin, Paula J, Nalls, Michael A, Adeyemo, Adebowale, Liu, Jiankang, Li, Guo, Ruiz-Narvaez, Edward A, Chen, Wei-Min, Chen, Fang, Henderson, Brian E, Millikan, Robert C, Ambrosone, Christine B, Strom, Sara S, Guo, Xiuqing, Andrews, Jeanette S, Sun, Yan V, Mosley, Thomas H, Yanek, Lisa R, Shriner, Daniel, Haritunians, Talin, Rotter, Jerome I, Speliotes, Elizabeth K, Smith, Megan, Rosenberg, Lynn, Mychaleckyj, Josyf, Nayak, Uma, Spruill, Ida, Garvey, W Timothy, Pettaway, Curtis, Nyante, Sarah, Bandera, Elisa V, Britton, Angela F, Zonderman, Alan B, Rasmussen-Torvik, Laura J, Chen, Yii-Der Ida, Ding, Jingzhong, Lohman, Kurt, Kritchevsky, Stephen B, Zhao, Wei, Peyser, Patricia A, Kardia, Sharon LR, Kabagambe, Edmond, Broeckel, Ulrich, Chen, Guanjie, Zhou, Jie, Wassertheil-Smoller, Sylvia, Neuhouser, Marian L, Rampersaud, Evadnie, Psaty, Bruce, Kooperberg, Charles, Manson, Joann E, Kuller, Lewis H, Ochs-Balcom, Heather M, Johnson, Karen C, Sucheston, Lara, Ordovas, Jose M, Palmer, Julie R, Haiman, Christopher A, McKnight, Barbara, Howard, Barbara V, Becker, Diane M, Bielak, Lawrence F, Liu, Yongmei, Allison, Matthew A, Grant, Struan FA, Burke, Gregory L, Patel, Sanjay R, Schreiner, Pamela J, Borecki, Ingrid B, Evans, Michele K, Taylor, Herman, Sale, Michele M, Howard, Virginia, Carlson, Christopher S, Rotimi, Charles N, Cushman, Mary, Harris, Tamara B, Reiner, Alexander P, Cupples, L Adrienne, North, Kari E, and Fox, Caroline S

Subjects
Humans, Obesity, Waist-Hip Ratio, Polymorphism, Single Nucleotide, African Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Adiposity, Body Fat Distribution, Genome-Wide Association Study, Genetic Loci, Polymorphism, Single Nucleotide, Developmental Biology, Genetics
Abstract

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values

Published
2013

49. Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate

Author

Aslibekyan, Stella, Goodarzi, Mark O, Frazier-Wood, Alexis C, Yan, Xiaofei, Irvin, Marguerite R, Kim, Eric, Tiwari, Hemant K, Guo, Xiuqing, Straka, Robert J, Taylor, Kent D, Tsai, Michael Y, Hopkins, Paul N, Korenman, Stanley G, Borecki, Ingrid B, Chen, Yii-Der I, Ordovas, Jose M, Rotter, Jerome I, and Arnett, Donna K

Subjects
Genetics, Cardiovascular, Clinical Research, Atherosclerosis, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adult, Apolipoprotein A-I, Apolipoproteins E, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Epistasis, Genetic, Female, Fenofibrate, Gene Frequency, Genome-Wide Association Study, Humans, Hypertriglyceridemia, Hypolipidemic Agents, Lipids, Male, Meta-Analysis as Topic, Microtubule-Associated Proteins, Middle Aged, Outcome Assessment, Health Care, Polymorphism, Single Nucleotide, Regression Analysis, Triglycerides, General Science & Technology
Abstract

A recent large-scale meta-analysis of genome-wide studies has identified 95 loci, 59 of them novel, as statistically significant predictors of blood lipid traits; we tested whether the same loci explain the observed heterogeneity in response to lipid-lowering therapy with fenofibrate. Using data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 861) we fit linear mixed models with the genetic markers as predictors and high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol, and triglyceride concentrations as outcomes. For all four traits, we analyzed both baseline levels and changes in response to treatment with fenofibrate. For the markers that were significantly associated with fenofibrate response, we fit additional models evaluating potential epistatic interactions. All models were adjusted for age, sex, and study center as fixed effects, and pedigree as a random effect. Statistically significant associations were observed between the rs964184 polymorphism near APOA1 (P-value≤0.0001) and fenofibrate response for HDL and triglycerides. The association was replicated in the Pharmacogenetics of Hypertriglyceridemia in Hispanics study (HyperTG, n = 267). Suggestive associations with fenofibrate response were observed for markers in or near PDE3A, MOSC1, FLJ36070, CETP, the APOE-APOC1-APOC4-APOC2, and CILP2. Finally, we present strong evidence for epistasis (P-value for interaction =  0.0006 in GOLDN, 0.05 in HyperTG) between rs10401969 near CILP2 and rs4420638 in the APOE-APOC1-APOC4-APOC2 cluster with total cholesterol response to fenofibrate. In conclusion, we present evidence linking several novel and biologically relevant genetic polymorphisms to lipid lowering drug response, as well as suggesting novel gene-gene interactions in fenofibrate pharmacogenetics.

Published
2012

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