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7. Influence of comorbidities on treatment considerations for first-line biologic prescribing in patients with inflammatory bowel disease in the UK

Author

Akbar, A, Orchard, T, Powell, N, Selinger, C, and Tibbatts, C

Subjects
Hepatology, Gastroenterology
Abstract

BackgroundAnti-tumour necrosis factor (anti-TNF) therapies are the most commonly used biologics for inflammatory bowel disease (IBD), but for patients with a comorbidity, newer agents may be a more appropriate treatment choice.AimsTo investigate the impact of comorbidities in patients with IBD, on first-line biologic prescribing habits of IBD-specialist healthcare practitioners in the UK.MethodsIBD-specialist physicians and nurses were asked to answer an online survey, considering different prescribing scenarios in ulcerative colitis (UC) and Crohn’s disease (CD). Respondents could indicate a preference for anti-TNFs or newer biologics, both in the absence and presence of 10 common comorbidities.ResultsA total of 120 IBD-specialist healthcare professionals (HCPs) completed the survey. In the absence of comorbidities, anti-TNFs were favoured; infliximab was the preferred first-line biologic in both UC and CD (43% and 37% of respondents, respectively). On introducing comorbidities, the largest shift in prescribing behaviour was for vedolizumab, with preference increasing by 27% and 21%, compared with infliximab, which fell by 14% and 9% in UC and CD, respectively. Chronic/recurring infection (46%), congestive heart failure (≤44%) and malignancies (≤43%) were the most commonly selected comorbidities for vedolizumab treatment.ConclusionsClinicians adapt their biologic prescribing habits in patients with IBD with comorbidities, considering known contraindications and precautions. A preference for vedolizumab is evident in many cases, however, for several comorbid scenarios, including demyelinating disorders, chronic obstructive pulmonary disease and malignancy, anti-TNFs are prescribed despite known risks. It is important that continual re-evaluation of the IBD treatment landscape is undertaken by HCPs, in alignment with recommendations in published guidelines.

Published
2022

8. Non-Lorentzian SU(1, n) Spacetime Symmetry In Various Dimensions

Author

Lambert, N, Mouland, R, Orchard, T, Mouland, Rishi [0000-0001-7811-4014], and Apollo - University of Cambridge Repository

Subjects
High Energy Physics - Theory, High Energy Physics - Theory (hep-th), Materials Science (miscellaneous), Biophysics, FOS: Physical sciences, conformal transformation, General Physics and Astronomy, non-lorentzian, supersymmetry, Physical and Theoretical Chemistry, quantum field theory, Mathematical Physics, symmetry
Abstract

We discuss non-Lorentzian Lagrangian field theories in $2n-1$ dimensions that admit an $SU(1,n)$ spacetime symmetry which includes a scaling transformation. These can be obtained by a conformal compactification of a $2n$-dimensional Minkowskian conformal field theory. We discuss the symmetry algebra, its representations including primary fields and unitarity bounds. We also give various examples of free theories in a variety of dimensions and a discussion of how to reconstruct the parent $2n$-dimensional theory., 31 pages, appendix added. Matches published version

Published
2022
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30. Erythrocyte omega-3 index, ambient fine particle exposure, and brain aging

Author

Kaufman, J.D., Chen, J.-C., Wang, X., He, K., Hayden, K.M., Chui, H.C., Vizuete, W., Espeland, M.A., Whitsel, E.A., Serre, M.L., Xun, P., Orchard, T., Harris, W.S., and Chen, C.

Abstract

OBJECTIVE: To examine whether long-chain omega-3 polyunsaturated fatty acid (LCn3PUFA) levels modify the potential neurotoxic effects of particle matter with diameters

Published
2020
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