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2. An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT

Author

Beksac, Meral, Iacobelli, Simona, Koster, Linda, Cornelissen, Jan, Griskevicius, Laimonas, Rabin, Neil K., Stoppa, Anne Marie, Meijer, Ellen, Mear, Jean-Baptiste, Zeerleder, Sacha, Mayer, Jiri, Fenk, Roland, Fegueux, Nathalie, Chevallier, Patrice, Konirova, Eva, Snowden, John A., Engelhardt, Monika, Orchard, Kim, Hulin, Cyrille, Schaap, Nicolaas, Sossa, Claudia, Elmaagacli, Ahmet, McLornan, Donal P., Hayden, Patrick J., Schönland, Stefan, and Yakoub-Agha, Ibrahim

Published
2023
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3. Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial

Author

Beesley, Richard, Churchill, Vicky, Insch, Elspeth, Loughton, Holly, MacDonald, Eilean, Lax, Siân, Lowe, Faye, Magwaro, Sophia, Gradwell, Mark, Kinsella, Francesca, Rolfe, Hayley, McIntyre, Stacey, Mortimer, Paige, Al-Taei, Saly, Tadros, Susan, Workman, Sarita, Arnott, Maxine, Brock, James, Melville, Andrew, Najm, Aurelie, Rutherford, Matthew, Sunzini, Flavia, Herman, Lou S, Hobbs, Agnieszka, Ragno, Martina, Wu, Mary Y, Selby, Rachael, Clay, Jennifer, Hutchison, Clare, Lown, Robert, Lwin, May N, Meardon, Naomi, Kelleher, Peter, Lightstone, Liz, Walters, Thomas, Denyer, Jayne, Ibrahim, Rahima, Gleeson, Sarah, Martin, Paul, McAdoo, Stephen, Baker, Helena, Horswill, Sarah, Parungao, Nina, Saich, Stephen, Cullinane, James, Irwin, Sophie, Klenerman, Paul, Marjot, Thomas, Chakraverty, Ronjon, Holroyd, Christopher, Kavi, Janki, Trown, Doreen, Babbage, Gavin, Chackathayil, Julia, Faria, Patricia, Ingham, Karen, Miah, Murad, Miranda, Mauro, O'Reilly, Nicola, Smith, Callie, Driver, Kimberley, Gauntlett, Kaylee, Farthing, Andrew, Rundell, Suzann, Smith, Emily, Tong, Andrew, Woolcock, Kieran, Hanke, Daniel, Laidlaw, Stephen, Malik, Zainab, Nguyen, Dung, Provine, Nicholas, Tipton, Tom, Walker, Victoria, Goodyear, Carl S, Patel, Amit, Barnes, Eleanor, Willicombe, Michelle, Siebert, Stefan, de Silva, Thushan I, Snowden, John A, Lim, Sean H, Bowden, Sarah J, Billingham, Lucinda, Richter, Alex, Carroll, Miles, Carr, Edward J, Beale, Rupert, Rea, Daniel, Parry, Helen, Pirrie, Sarah, Lim, Zixiang, Satsangi, Jack, Dunachie, Susanna J, Cook, Gordon, Miller, Paul, Basu, Neil, Gilmour, Ashley, Hodgkins, Anne-Marie, Evans, Lili, Hughes, Ana, Longet, Stephanie, Meacham, Georgina, Yong, Kwee L, A'Hearne, Matthew J, Koh, Mickey B C, Burns, Siobhan O, Orchard, Kim, Paterson, Caron, McIlroy, Graham, Murray, Sam M, Thomson, Tina, Dimitriadis, Stavros, Goulston, Lyndsey, Miller, Samantha, Keillor, Victoria, Prendecki, Maria, Thomas, David, Kirkham, Amanda, McInnes, Iain B, and Kearns, Pamela

Published
2024
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4. SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Author

Barnes, Eleanor, Goodyear, Carl S., Willicombe, Michelle, Gaskell, Charlotte, Siebert, Stefan, I de Silva, Thushan, Murray, Sam M., Rea, Daniel, Snowden, John A., Carroll, Miles, Pirrie, Sarah, Bowden, Sarah J., Dunachie, Susanna J., Richter, Alex, Lim, Zixiang, Satsangi, Jack, Cook, Gordon, Pope, Ann, Hughes, Ana, Harrison, Molly, Lim, Sean H., Miller, Paul, Klenerman, Paul, Basu, Neil, Gilmour, Ashley, Irwin, Sophie, Meacham, Georgina, Marjot, Thomas, Dimitriadis, Stavros, Kelleher, Peter, Prendecki, Maria, Clarke, Candice, Mortimer, Paige, McIntyre, Stacey, Selby, Rachael, Meardon, Naomi, Nguyen, Dung, Tipton, Tom, Longet, Stephanie, Laidlaw, Stephen, Orchard, Kim, Ireland, Georgina, Thomas, David, Kearns, Pamela, Kirkham, Amanda, and McInnes, Iain B.

Published
2023
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5. Allogeneic stem cell transplantation for chronic lymphocytic leukemia in the era of novel agents.

Author

Roeker, Lindsey, Dreger, Peter, Brown, Jennifer, Lahoud, Oscar, Eyre, Toby, Brander, Danielle, Skarbnik, Alan, Coombs, Catherine, Kim, Haesook, Davids, Matthew, Manchini, Steven, George, Gemlyn, Shah, Nirav, Voorhees, Timothy, Orchard, Kim, Walter, Harriet, Arumainathan, Arvind, Sitlinger, Andrea, Park, Jae, Geyer, Mark, Zelenetz, Andrew, Sauter, Craig, Giralt, Sergio, Perales, Miguel-Angel, and Mato, Anthony

Subjects
Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Follicular, Retrospective Studies
Abstract

Although novel agents (NAs) have improved outcomes for patients with chronic lymphocytic leukemia (CLL), a subset will progress through all available NAs. Understanding outcomes for potentially curative modalities including allogeneic hematopoietic stem cell transplantation (alloHCT) following NA therapy is critical while devising treatment sequences aimed at long-term disease control. In this multicenter, retrospective cohort study, we examined 65 patients with CLL who underwent alloHCT following exposure to ≥1 NA, including baseline disease and transplant characteristics, treatment preceding alloHCT, transplant outcomes, treatment following alloHCT, and survival outcomes. Univariable and multivariable analyses evaluated associations between pre-alloHCT factors and progression-free survival (PFS). Twenty-four-month PFS, overall survival (OS), nonrelapse mortality, and relapse incidence were 63%, 81%, 13%, and 27% among patients transplanted for CLL. Day +100 cumulative incidence of grade III-IV acute graft-vs-host disease (GVHD) was 24%; moderate-severe GVHD developed in 27%. Poor-risk disease characteristics, prior NA exposure, complete vs partial remission, and transplant characteristics were not independently associated with PFS. Hematopoietic cell transplantation-specific comorbidity index independently predicts PFS. PFS and OS were not impacted by having received NAs vs both NAs and chemoimmunotherapy, 1 vs ≥2 NAs, or ibrutinib vs venetoclax as the line of therapy immediately pre-alloHCT. AlloHCT remains a viable long-term disease control strategy that overcomes adverse CLL characteristics. Prior NAs do not appear to impact the safety of alloHCT, and survival outcomes are similar regardless of number of NAs received, prior chemoimmunotherapy exposure, or NA immediately preceding alloHCT. Decisions about proceeding to alloHCT should consider comorbidities and anticipated response to remaining therapeutic options.

Published
2020

6. Comparison of fludarabine–melphalan and fludarabine–treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesus, Finke, Jürgen, Labopin, Myriam, Craddock, Charles, Protheroe, Rachel, Kottaridis, Panagiotis, Tholouli, Eleni, Byrne, Jenny L., Orchard, Kim, Salmenniemi, Urpu, Hilgendorf, Inken, Hunter, Hannah, Nicholson, Emma, Bloor, Adrian, Snowden, John A., Verbeek, Mareike, Clark, Andrew, Savani, Bipin N., Spyridonidis, Alexandros, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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7. Comorbidities in transplant recipients with acute myeloid leukemia receiving low-intensity conditioning regimens: an ALWP EBMT study

Author

Fein, Joshua A., Shouval, Roni, Galimard, Jacques-Emmanuel, Labopin, Myriam, Socié, Gérard, Finke, Jürgen, Cornelissen, Jan J., Malladi, Ram, Itälä-Remes, Maija, Chevallier, Patrice, Orchard, Kim H., Bunjes, Donald, Aljurf, Mahmoud, Rubio, Marie Thérèse, Versluis, Jurjen, Mohty, Mohamad, and Nagler, Arnon

Published
2023
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8. Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial

Author

Goodyear, Carl S, primary, Patel, Amit, additional, Barnes, Eleanor, additional, Willicombe, Michelle, additional, Siebert, Stefan, additional, de Silva, Thushan I, additional, Snowden, John A, additional, Lim, Sean H, additional, Bowden, Sarah J, additional, Billingham, Lucinda, additional, Richter, Alex, additional, Carroll, Miles, additional, Carr, Edward J, additional, Beale, Rupert, additional, Rea, Daniel, additional, Parry, Helen, additional, Pirrie, Sarah, additional, Lim, Zixiang, additional, Satsangi, Jack, additional, Dunachie, Susanna J, additional, Cook, Gordon, additional, Miller, Paul, additional, Basu, Neil, additional, Gilmour, Ashley, additional, Hodgkins, Anne-Marie, additional, Evans, Lili, additional, Hughes, Ana, additional, Longet, Stephanie, additional, Meacham, Georgina, additional, Yong, Kwee L, additional, A'Hearne, Matthew J, additional, Koh, Mickey B C, additional, Burns, Siobhan O, additional, Orchard, Kim, additional, Paterson, Caron, additional, McIlroy, Graham, additional, Murray, Sam M, additional, Thomson, Tina, additional, Dimitriadis, Stavros, additional, Goulston, Lyndsey, additional, Miller, Samantha, additional, Keillor, Victoria, additional, Prendecki, Maria, additional, Thomas, David, additional, Kirkham, Amanda, additional, McInnes, Iain B, additional, Kearns, Pamela, additional, Beesley, Richard, additional, Churchill, Vicky, additional, Insch, Elspeth, additional, Loughton, Holly, additional, MacDonald, Eilean, additional, Lax, Siân, additional, Lowe, Faye, additional, Magwaro, Sophia, additional, Gradwell, Mark, additional, Kinsella, Francesca, additional, Rolfe, Hayley, additional, McIntyre, Stacey, additional, Mortimer, Paige, additional, Al-Taei, Saly, additional, Tadros, Susan, additional, Workman, Sarita, additional, Arnott, Maxine, additional, Brock, James, additional, Melville, Andrew, additional, Najm, Aurelie, additional, Rutherford, Matthew, additional, Sunzini, Flavia, additional, Herman, Lou S, additional, Hobbs, Agnieszka, additional, Ragno, Martina, additional, Wu, Mary Y, additional, Selby, Rachael, additional, Clay, Jennifer, additional, Hutchison, Clare, additional, Lown, Robert, additional, Lwin, May N, additional, Meardon, Naomi, additional, Kelleher, Peter, additional, Lightstone, Liz, additional, Walters, Thomas, additional, Denyer, Jayne, additional, Ibrahim, Rahima, additional, Gleeson, Sarah, additional, Martin, Paul, additional, McAdoo, Stephen, additional, Baker, Helena, additional, Horswill, Sarah, additional, Parungao, Nina, additional, Saich, Stephen, additional, Cullinane, James, additional, Irwin, Sophie, additional, Klenerman, Paul, additional, Marjot, Thomas, additional, Chakraverty, Ronjon, additional, Holroyd, Christopher, additional, Kavi, Janki, additional, Trown, Doreen, additional, Babbage, Gavin, additional, Chackathayil, Julia, additional, Faria, Patricia, additional, Ingham, Karen, additional, Miah, Murad, additional, Miranda, Mauro, additional, O'Reilly, Nicola, additional, Smith, Callie, additional, Driver, Kimberley, additional, Gauntlett, Kaylee, additional, Farthing, Andrew, additional, Rundell, Suzann, additional, Smith, Emily, additional, Tong, Andrew, additional, Woolcock, Kieran, additional, Hanke, Daniel, additional, Laidlaw, Stephen, additional, Malik, Zainab, additional, Nguyen, Dung, additional, Provine, Nicholas, additional, Tipton, Tom, additional, and Walker, Victoria, additional

Published
2024
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9. Correction: An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT

Author

Beksac, Meral, Iacobelli, Simona, Koster, Linda, Cornelissen, Jan, Griskevicius, Laimonas, Rabin, Neil K., Stoppa, Anne Marie, Meijer, Ellen, Mear, Jean-Baptiste, Zeerleder, Sacha, Mayer, Jiri, Fenk, Roland, Fegueux, Nathalie, Chevallier, Patrice, Konirova, Eva, Snowden, John A., Engelhardt, Monika, Orchard, Kim, Hulin, Cyrille, Schaap, Nicolaas, Sossa, Claudia, Elmaagacli, Ahmet, McLornan, Donal P., Hayden, Patrick J., Schönland, Stefan, and Yakoub-Agha, Ibrahim

Published
2023
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10. Worldwide Network for Blood and Marrow Transplantation Special Article on Key Elements in Quality and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy

Author

Alseraihy, Amal, McGrath, Eoin, Niederwieser, Dietger, Chabannon, Christian, Szer, Jeff, Mohty, Mohamad, Kharfan-Dabaja, Mohamed A., Orchard, Kim, Schwartz, Joseph, Rasheed, Walid, Koh, Mickey, Kröger, Nicolaus, Kodera, Yoshihisa, Fakih, Riad El, Worel, Nina, Manson, Lynn, Rintala, Tuula, Tabakhi, Abdelghani, Savani, Bipin, Gergis, Usama, Sureda, Anna, Eldridge, Paul W., Yakoub‐Agha, Ibrahim, Hamadani, Mehdi, Weisdorf, Daniel, Greinix, Hildegard, and Aljurf, Mahmoud

Published
2022
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11. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey

Author

Ljungman, Per, de la Camara, Rafael, Mikulska, Malgorzata, Tridello, Gloria, Aguado, Beatriz, Zahrani, Mohsen Al, Apperley, Jane, Berceanu, Ana, Bofarull, Rodrigo Martino, Calbacho, Maria, Ciceri, Fabio, Lopez-Corral, Lucia, Crippa, Claudia, Fox, Maria Laura, Grassi, Anna, Jimenez, Maria-Jose, Demir, Safiye Koçulu, Kwon, Mi, Llamas, Carlos Vallejo, Lorenzo, José Luis López, Mielke, Stephan, Orchard, Kim, Porras, Rocio Parody, Vallisa, Daniele, Xhaard, Alienor, Knelange, Nina Simone, Cedillo, Angel, Kröger, Nicolaus, Piñana, José Luis, and Styczynski, Jan

Published
2021
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13. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Author

Petersdorf, Effie W, Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J Alejandro, Maiers, Martin, Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen, Villard, Jean, Stevenson, Phil, Apperley, Jane, Bardy, Peter, Bernard, Ghislaine, Bertrand, Yves, Bloor, Adrian, Bonini, Chiara, Buhler, Stephane, Bungener, Laura, Campbell, Helen, Carlson, Kristina, Carpenter, Ben, Cesbron, Anne, Chabannon, Christian, Chalandon, Yves, Chapman, Jeremy, Chebel, Réda, Chevallier, Patrice, Choi, Gerda, Collin, Matt, Cornelissen, Jan J, Crawley, Charles, D'Orsogna, Lloyd, Dalle, Jean-Hugues, Deconinck, Eric, DeMatteis, Muriel, Diviney, Mary, Dormoy, Anne, Gagne, Katia, Gibson, Brenda, Gilleece, Maria, Gottlieb, David, Gribben, John, Güngör, Tayfun, Haagenson, Mike, Hart, Cathie, Holdsworth, Rhonda, Humphreys, Ian, Kodera, Yoshihisa, Koh, Mickey, Labussière-Wallet, Hélène, Lankester, Arjan C, Lardy, Neubery, Lawson, Sarah, Leleu, Xavier, MacKinnon, Stephen, Malladi, Ram, Marsh, Steven GE, Martin, Murray, Mayor, Neema P, McQuaker, I Grant, Meijer, Ellen, Morishima, Satoko, Nikolousis, Emmanouil, Orchard, Kim, Passweg, Jacob, Patel, Amit, Patrick, Katherine, Pedron, Béatrice, Peniket, Andy, Perry, Julia, Petersen, Eefke, Potter, Victoria, Potter, Mike, Protheroe, Rachel, Raus, Nicole, Ruiz de Elvira, Carmen, Russell, Nigel, Schaap, Nicholaas PM, Schanz, Urs, Schouten, Harry, Skinner, Roderick, Snowden, John, Spierings, Eric, Steward, Colin, Tholouli, Eleni, Thornton, Alycia, Tilanus, Marcel, van de Meer, Arnold, Veelkens, Hendrik, Veys, Paul, Watson, Narelle, Weston, Lyanne, Wilson, Keith, Wilson, Marie, Wynn, Robert, Zsiros, József, Maiers, Martin J, and Spellman, Stephen R

Published
2020
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14. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, Houghton, John, additional, Jowitt, Simon, additional, Thomas-Dewing, Rowena, additional, Williams, Mark, additional, Zaman, Sonya, additional, Cullis, Jonathan, additional, Everington, Tamara, additional, Grand, Effie, additional, Hasan, Yasmin, additional, Murrin, Richard, additional, Wandoo, Farooq, additional, Ismail, Saad, additional, Mohite, Unmesh, additional, Sati, Hamdi, additional, Jenner, Matthew, additional, Orchard, Kim, additional, Richardson, Deborah, additional, McCloskey, Kayleigh, additional, Xu Chin, Kate, additional, Fenella Willis, Neoh, additional, Sud, Amit, additional, Gharib, Maged, additional, Nicholson, Toby, additional, Bowen, David, additional, Janes, Sarah, additional, Eagleton, Helen, additional, O'Hea, Anne-Marie, additional, Pattinson, Jonathan, additional, Hervey, Victoria, additional, Lyons, Simon, additional, Marshall, Scott, additional, Nicolle, Annette, additional, Vavyla, Maria, additional, Burgess, Jordan, additional, Somervaille, Tim, additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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15. Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML

Author

Bultitude, Will P., Schellekens, Jennifer, Szydlo, Richard M., Anthias, Chloe, Cooley, Sarah A., Miller, Jeffrey S., Weisdorf, Daniel J., Shaw, Bronwen E., Roberts, Chrissy h., Garcia-Sepulveda, Christian A., Lee, Julia, Pearce, Rachel M., Wilson, Marie C., Potter, Michael N., Byrne, Jenny L., Russell, Nigel H., MacKinnon, Stephen, Bloor, Adrian J., Patel, Amit, McQuaker, I. Grant, Malladi, Ram, Tholouli, Eleni, Orchard, Kim, Potter, Victoria T., Madrigal, J. Alejandro, Mayor, Neema P., and Marsh, Steven G. E.

Published
2020
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16. Reducing the diversity of allogeneic transplant protocols in the UK through a BSBMT Anthony Nolan Protocol Harmonization Initiative

Author

Anthias, Chloe, Apperley, Jane, Bloor, Adrian, Byrne, Jennifer, Collin, Matthew, Crawley, Charles, Craddock, Charles, Finnegan, Damian, Gilleece, Maria, Gribben, John, Hunter, Ann, Hunter, Hannah, Koh, Mickey, Mackinnon, Stephen, Malladi, Ram, Marks, David, McQuaker, Grant, Nikolousis, Manos, Orchard, Kim, Pavlu, Jiri, Peniket, Andrew, Potter, Mike, Potter, Victoria, Robinson, Stephen, Russell, Nigel, Salim, Rahuman, Snowden, John, Thomson, Kirsty, Tholouli, Eleni, and Wilson, Keith

Published
2020
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18. Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Snowden, John A., Saccardi, Riccardo, Orchard, Kim, Ljungman, Per, Duarte, Rafael F., Labopin, Myriam, McGrath, Eoin, Brook, Nigel, de Elvira, Carmen Ruiz, Gordon, Debra, Poirel, Hélène A., Ayuk, Francis, Beguin, Yves, Bonifazi, Francesca, Gratwohl, Alois, Milpied, Noel, Moore, John, Passweg, Jakob, Rizzo, J. Douglas, Spellman, Stephen R., Sierra, Jorge, Solano, Carlos, Sanchez-Guijo, Fermin, Worel, Nina, Gusi, Andreu, Adams, Gillian, Balan, Theodor, Baldomero, Helen, Macq, Gilles, Marry, Evelyne, Mesnil, Florence, Oldani, Elena, Pearce, Rachel, Perry, Julia, Raus, Nicole, Schanz, Urs, Tran, Steven, Wilcox, Leonie, Basak, Grzegorz W., Chabannon, Christian, Corbacioglu, Selim, Dolstra, Harry, Kuball, Jürgen, Mohty, Mohamad, Lankester, Arjan, Montoto, Sylvia, Nagler, Arnon, Styczynski, Jan, Yakoub-Agha, Ibrahim, de Latour, Regis Peffault, Kroeger, Nicolaus, Brand, Ronald, de Wreede, Liesbeth C., van Zwet, Erik, and Putter, Hein

Published
2020
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19. Cellular factors that interact with the negative regulatory element in the 5'-long terminal repeat of human immunodeficiency virus type 1

Author

Orchard, Kim Harold

Subjects
572.8, Genetics
Abstract

Transcriptional regulation of HlV-1 gene expression has been shown to be regulated by a combination of viral and cellular proteins which bind to regulatory elements in the viral 5' long terminal repeat (5'LTR) Functionally the LTR can be divided into three regulatory regions: the TAR region, extending from nucleotides 1 to 60 relative to the start site of transcription, contains sequences with which the viral trans-activator Tat interacts. The adjacent region from nucleotides -1 to -78 contains the core promoter with elements crucial for both basal and Tat-induced expression. The third region, extending from -79 to -454, contains numerous elements with which a variety of cellular factors may interact, resulting in either positive or negative modulation of LTR-driven transcription. The work contained within this thesis describes the discovery and delineation of two new transcription factor binding sites, designated as site A and site B, within the 5'-LTR of HIV-1. The majority of the work focused on site B itself, involving the characterisation of cellular proteins that specifically interacted with the nucleotide sequences in this site. Site B was found to contain a palindromic sequence TGACC involved in protein-DNA contact separated by a 9 base-pair spacer sequence that was not important for protein binding. This palindrome resembles the consensus binding site for members of the nuclear hormone receptor super-family of transcription factors. Although several members of this super-family of transcription factors were shown to interact in vitro with site B, the predominant protein present in T-lymphocyte nuclear extracts did not correspond to any of those previously characterised. The T-cell protein was shown to have a relative molecular size of 100-110 kD for the monomeric polypeptide and bound to site B as a dimer. Maximal binding to site B required both halves of the palindrome. Functionally site B was shown to act as a repressor element of both basal transcription and of transcription activated by phorbol ester in T- lymphocytes. Site B was also shown to function as a retinoic acid response element (RARE) in a heterologous promoter. The ability to function as either a positive or negative regulatory element is a recognised characteristic of nuclear hormone response elements and in part is a function of the relative abundance of factors able to interact with the site or to form complexes with one another. The overall effect of site B upon LTR-directed transcription may similarly depend upon the complex interaction of multiple factors which themselves depend on the cell type, cell activation state and degree of differentiation.

Published
1999

20. Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Author

Jesus Duque-Afonso, Jürgen Finke, Maud Ngoya, Jacques-Emmanuel Galimard, Charles Craddock, Kavita Raj, Adrian Bloor, Emma Nicholson, Matthias Eder, Orchard Kim, Thomas Valerius, John Snowden, Eleni Tholouli, Charles Crawley, Matthew Collin, Keith Wilson, Alain Gadisseur, Rachel Protheroe, Eva Wagner-Drouet, Bipin Savani, Alexandros Spyridonidis, Fabio Ciceri, Arnon Nagler, and Mohamad Mohty

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Abstract

The authors have requested that this preprint be removed from Research Square.

Published
2022

21. Benchmarking of survival outcomes following Haematopoietic Stem Cell Transplantation (HSCT): an update of the ongoing project of the European Society for Blood and Marrow Transplantation (EBMT) and Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Saccardi, Riccardo, primary, Putter, Hein, additional, Eikema, Dirk-Jan, additional, Busto, María Paula, additional, McGrath, Eoin, additional, Middelkoop, Bas, additional, Adams, Gillian, additional, Atlija, Marina, additional, Ayuk, Francis Ayuketang, additional, Baldomero, Helen, additional, Beguin, Yves, additional, de la Cámara, Rafael, additional, Cedillo, Ángel, additional, Balari, Anna María Sureda, additional, Chabannon, Christian, additional, Corbacioglu, Selim, additional, Dolstra, Harry, additional, Duarte, Rafael F., additional, Dulery, Rémy, additional, Greco, Raffaella, additional, Gusi, Andreu, additional, Hamad, Nada, additional, Kenyon, Michelle, additional, Kröger, Nicolaus, additional, Labopin, Myriam, additional, Lee, Julia, additional, Ljungman, Per, additional, Manson, Lynn, additional, Mensil, Florence, additional, Milpied, Noel, additional, Mohty, Mohamad, additional, Oldani, Elena, additional, Orchard, Kim, additional, Passweg, Jakob, additional, Pearce, Rachel, additional, de Latour, Régis Peffault, additional, Poirel, Hélène A., additional, Rintala, Tuula, additional, Rizzo, J. Douglas, additional, Ruggeri, Annalisa, additional, Sanchez-Martinez, Carla, additional, Sanchez-Guijo, Fermin, additional, Sánchez-Ortega, Isabel, additional, Trnková, Marie, additional, Ferreiras, David Valcárcel, additional, Wilcox, Leonie, additional, de Wreede, Liesbeth C., additional, and Snowden, John A., additional

Published
2023
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22. Comorbidities in transplant recipients with acute myeloid leukemia receiving low-intensity conditioning regimens:an ALWP EBMT study

Author

Fein, Joshua A., Shouval, Roni, Galimard, Jacques Emmanuel, Labopin, Myriam, Socié, Gérard, Finke, Jürgen, Cornelissen, Jan J., Malladi, Ram, Itälä-Remes, Maija, Chevallier, Patrice, Orchard, Kim H., Bunjes, Donald, Aljurf, Mahmoud, Rubio, Marie Thérèse, Versluis, Jurjen, Mohty, Mohamad, Nagler, Arnon, Fein, Joshua A., Shouval, Roni, Galimard, Jacques Emmanuel, Labopin, Myriam, Socié, Gérard, Finke, Jürgen, Cornelissen, Jan J., Malladi, Ram, Itälä-Remes, Maija, Chevallier, Patrice, Orchard, Kim H., Bunjes, Donald, Aljurf, Mahmoud, Rubio, Marie Thérèse, Versluis, Jurjen, Mohty, Mohamad, and Nagler, Arnon

Abstract

Older age and a high burden of comorbidities often drive the selection of low-intensity conditioning regimens in allogeneic hematopoietic stem cell transplantation recipients. However, the impact of comorbidities in the low-intensity conditioning setting is unclear. We sought to determine the contribution of individual comorbidities and their cumulative burden on the risk of nonrelapse mortality (NRM) among patients receiving low-intensity regimens. In a retrospective analysis of adults (≥18 years) who underwent transplantation for acute myeloid leukemia in the first complete remission between 2008 and 2018, we studied recipients of low-intensity regimens as defined by the transplantation conditioning intensity (TCI) scale. Multivariable Cox models were constructed to study associations of comorbidities with NRM. Comorbidities identified as putative risk factors in the low-TCI setting were included in combined multivariable regression models assessed for overall survival, NRM, and relapse. A total of 1663 patients with a median age of 61 years received low-TCI regimens. Cardiac comorbidity (including arrhythmia/valvular disease) and psychiatric disease were associated with increased NRM risk (hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.13-2.09 and HR, 1.69; 95% CI, 1.02-2.82, respectively). Moderate pulmonary dysfunction, though prevalent, was not associated with increased NRM. In a combined model, cardiac, psychiatric, renal, and inflammatory bowel diseases were independently associated with adverse transplantation outcomes. These findings may inform patient and regimen selection and reinforce the need for further investigation of cardioprotective transplantation approaches.

Published
2023

23. Correction: Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Snowden, John A., Saccardi, Riccardo, Orchard, Kim, Ljungman, Per, Duarte, Rafael F., Labopin, Myriam, McGrath, Eoin, Brook, Nigel, de Elvira, Carmen Ruiz, Gordon, Debra, Poirel, Hélène A., Ayuk, Francis, Beguin, Yves, Bonifazi, Francesca, Gratwohl, Alois, Milpied, Noel, Moore, John, Passweg, Jakob, Rizzo, J. Douglas, Spellman, Stephen R., Sierra, Jorge, Solano, Carlos, Sanchez-Guijo, Fermin, Worel, Nina, Gusi, Andreu, Adams, Gillian, Balan, Theodor, Baldomero, Helen, Macq, Gilles, Marry, Evelyne, Mesnil, Florence, Oldani, Elena, Pearce, Rachel, Perry, Julia, Raus, Nicole, Schanz, Urs, Tran, Steven, Wilcox, Leonie, Basak, Grzegorz W., Chabannon, Christian, Corbacioglu, Selim, Dolstra, Harry, Kuball, Jürgen, Mohty, Mohamad, Lankester, Arjan, Montoto, Sylvia, Nagler, Arnon, Styczynski, Jan, Yakoub-Agha, Ibrahim, de Latour, Regis Peffault, Kroeger, Nicolaus, Brand, Ronald, de Wreede, Liesbeth C., van Zwet, Erik, and Putter, Hein

Published
2020
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24. Comorbidities in recipients of low transplant conditioning intensity regimens for acute myeloid leukemia: an ALWP EBMT study

Author

Fein, Joshua Alexander, primary, Shouval, Roni, additional, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Socié, Gerard, additional, Finke, Jürgen, additional, Cornelissen, Jan J, additional, Malladi, Ram, additional, Itälä-Remes, Maija, additional, Chevallier, Patrice, additional, Orchard, Kim, additional, Bunjes, Donald, additional, Aljurf, Mahmoud, additional, Rubio, Marie-Thérèse, additional, Versluis, Jurjen, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2023
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25. Immunogenicity of SARSCoV2 Third Dose Vaccine Strategies in Immunocompromised Patients with Suboptimal Immunity Following Two Doses (OCTAVE-DUO): An Open-Label, Multi-Centre, Randomised, Controlled Phase III Trial

Author

Goodyear, Carl S., primary, Patel, Amit, additional, Barnes, Eleanor, additional, willicombe, michelle, additional, Siebert, Stefan, additional, de Silva, Thushan I., additional, Snowden, John A., additional, Lim, Sean, additional, Bowden, Sarah, additional, Billingham, Lucinda J., additional, Richter, Alex G., additional, Carroll, Miles W., additional, Carr, Edward J., additional, Beale, Rupert, additional, Rea, Daniel, additional, Parry, Helen, additional, Pirrie, Sarah, additional, Lim, Zixiang, additional, Satsangi, Jack, additional, Dunachie, Susanna, additional, Cook, Gordon, additional, Miller, Paul, additional, Basu, Neil, additional, Gilmour, Ashley, additional, Hodgkins, Anne-Marie, additional, Evans, Lili, additional, Hughes, Ana, additional, Longet, Stephanie, additional, Meacham, Georgina, additional, Yong, Kwee, additional, Ahearne, Matthew, additional, Koh, Mickey B. C., additional, Burns, Siobhan O., additional, Orchard, Kim, additional, Paterson, Caron, additional, McIlroy, Graham, additional, Murray, Sam M., additional, Thomson, Tina, additional, Dimitriadis, Stavros, additional, Goulston, Lyndsey, additional, Miller, Samantha, additional, Keillor, Victoria, additional, Prendecki, Maria, additional, Thomas, David, additional, Kirkham, Amanda, additional, McInnes, Iain, additional, and Kearns, Pamela, additional

Published
2023
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26. Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

Author

Galleu, Antonio, Riffo-Vasquez, Yanira, Trento, Cristina, Lomas, Cara, Dolcetti, Luigi, Cheung, Tik Shing, von Bonin, Malte, Barbieri, Laura, Halai, Krishma, Ward, Sophie, Weng, Ling, Chakraverty, Ronjon, Lombardi, Giovanna, Watt, Fiona M., Orchard, Kim, Marks, David I., Apperley, Jane, Bornhauser, Martin, Walczak, Henning, Bennett, Clare, and Dazzi, Francesco

Published
2017
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27. Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Author

Duque Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Orchard, Kim H., additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew P., additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel Elizabeth, additional, Wagner, Eva Maria, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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30. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, de Wreede, Liesbeth C., Müller, Carlheinz R., Crivello, Pietro, Bonneville, Edouard F., Petersdorf, Effie W., Socié, Gerard, Dubois, Valérie, Niittyvuopio, Riitta, Peräsaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J., Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R., Marsh, Steven G.E., Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itäla-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, van Gorkom, Gwendolyn, Hoogenboom, Jorinde D., Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, Fleischhauer, Katharina, Clausen, Johannes, Holter, Wolfgang, Kalhs, Peter, Beguin, Yves, Bron, Dominique, Deeren, Dries, Lung, Wu Ka, Kerre, Tessa, Poiré, Xavier, Selleslag, Dominik, Schroyens, Wilfried, Jindra, Pavel, Mayer, Jiri, Vydra, Jan, Zák, Pavel, Nielsen, Bendt, Sengeloev, Henrik, Kaare, Ain, Partanen, Anu, Bay, Jacques-Olivier, Bertrand, Yves, Blaise, Didier, Bourhis, Jean Henri, Chevallier, Patrice, Cluzeau, Thomas, Damaj, Gandhi, Fegueux, Nathalie, Guyotat, Denis, Hunault-Berger, Mathilde, Labussière-Wallet, Hélène, Leleu, Xavier, Lioure, Bruno, Maury, Sebastien, Michel, Gérard, Mohty, Mohamad, Rubio, Marie Thérèse, Tilly, Herve, Turlure, Pascal, Bethge, Wolfgang, Casper, Jochen, Einsele, Hermann, Ganser, Arnold, Kröger, Nicolaus, Martin, Sonja, Platzbecker, Uwe, Reinhardt, Christian, Schäfer-Eckart, Kerstin, Thurner, Lorenz, Valerius, Thomas, Wulf, Gerald G., Karakasis, Dimitrios, Spyridonidis, Alexandros, Hauser, Peter, Reményi, Péter, Reykdal, Sigrun, Mousavi, Ashrafsadat, Angelucci, Emanuele, Arcese, William, Benedetti, Fabio, Bernasconi, Paolo, Biondi, Andrea, Bonifazi, Francesca, Carella, Angelo Michele, Carluccio, Paola, Casini, Marco, Cavanna, Luigi, Ciceri, Fabio, Cimino, Giuseppe, Corradini, Paolo, Fanin, Renato, Galieni, Piero, Grillo, Giovanni, Iori, Anna Paola, La Nasa, Giorgio, Locatelli, Franco, Marotta, Giuseppe, Martino, Massimo, Mazza, Patrizio, Mordini, Nicola, Musso, Maurizio, Olivieri, Attilio, Pavone, Vincenzo, Pane, Fabrizio, Petrini, Mario, Pioltelli, Pietro, Rambaldi, Alessandro, Ruggeri, Marco, Saccardi, Riccardo, Santarone, Stella, Scimè, Rosanna, Sica, Simona, Tarella, Corrado, Velardi, Andrea, Visani, Giuseppe, Zecca, Marco, Tanase, Alina, Kulagin, Aleksandr, Savchenko, Valery, López, Carmen Albo, Amor, Adrián Alegre, López, Jose Luis Bello, Caballero, Dolores, Duarte, Rafael, Cascon, Maria Jesús Pascual, Porras, Rocio Parody, Pérez-Simón, Jose Antonio, Rovira, Montserrat, Sanz, Jaime, Carrete, Juan Pio Torres, Cammenga, Jörg, Isaksson, Cecilia, Mielke, Stephan, Chalandon, Yves, Passweg, Jakob, Schanz, Urs, Meijer, Ellen, Kuball, Jürgen, Veelken, Joan Hendrik, Apperley, Jane, Bloor, Adrian, Byrne, Jenny, Carpenter, Ben, Clark, Andrew, Collin, Matthew, Craddock, Charles, Gibson, Brenda E., Khan, Anjum, Martin, Murray, Medd, Patrick, Nicholson, Emma, Orchard, Kim, Patel, Amit, Peniket, Andy, Potter, Victoria, Snowden, John, Wilson, Keith M.O., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Transplant. Immunology/Tissue Typing lab, Interne Geneeskunde, MUMC+: MA Hematologie (9), Hematology, IRCCS San Raffaele Scientific Institute [Milan, Italie], EFS, CHU Lille, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], Oslo University Hospital [Oslo], CHU Bordeaux [Bordeaux], CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University of Groningen [Groningen], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), and Essen University Hospital

Subjects
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, [SDV]Life Sciences [q-bio], HSCT, Medizin, Hematology, Hematologi
Abstract

International audience; Not available.

Published
2023

31. Correction:An early post-transplant relapse prediction score in multiple myeloma: a large cohort study from the chronic malignancies working party of EBMT (Bone Marrow Transplantation, (2023), 10.1038/s41409-023-01999-1)

Author

Beksac, Meral, Iacobelli, Simona, Koster, Linda, Cornelissen, Jan, Griskevicius, Laimonas, Rabin, Neil K., Stoppa, Anne Marie, Meijer, Ellen, Mear, Jean-Baptiste, Zeerleder, Sacha, Mayer, Jiri, Fenk, Roland, Fegueux, Nathalie, Chevallier, Patrice, Konirova, Eva, Snowden, John A., Engelhardt, Monika, Orchard, Kim, Hulin, Cyrille, Schaap, Nicolaas, Sossa, Claudia, Elmaagacli, Ahmet, McLornan, Donal P., Hayden, Patrick J., Schönland, Stefan, and Yakoub-Agha, Ibrahim

Abstract

Correction to: Bone Marrow Transplantation, published online 09 May 2023 In this article, the second affiliation of Claudia Sossa was missing. It should be Universidad Autónoma de Bucaramanga—UNAB, Bucaramanga, Santander, Colombia. The original article has been corrected.

Published
2023

32. Total body irradiation + fludarabine compared to busulfan + fludarabine as 'reduced-toxicity conditioning' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Sobczyk-Kruszelnicka, Malgorzata, Stelljes, Matthias, Byrne, Jenny, Fegueux, Nathalie, Beelen, Dietrich, Rovira, Montserrat, Spyridonidis, Alexandros, Blaise, Didier, Bornhäuser, Martin, Karadogan, Ihsan, Savani, Bipin, Nagler, Arnon, Mohty, Mohamad, Martin, Sonja, Chevallier, Patrice, Neubauer, Andreas, Damaj, Gandhi, Koc, Yener, Ganser, Arnold, Collin, Matthew, Yakoub-Agha, Ibrahim, Ozdogu, Hakan, Araujo, Mercedes Colorado, Itäla-Remes, Maija, Orchard, Kim, Isaksson, Cecilia, Bethge, Wolfgang, Martin, Hans, Aljurf, Mahmoud, Faber, Edgar, Caballero, Dolores, Zák, Pavel, Leleu, Xavier, Bay, Jacques-Olivier, Rohrlich, Pierre-Simon, Kröger, Nicolaus, Huynh, Anne, Schäfer-Eckart, Kerstin, Milpied, Noel, Lenhoff, Stig, Ho, Aloysius, López, Jose Luis Bello, Mordini, Nicola, Lioure, Bruno, Halaburda, Kazimierz, Olivieri, Attilio, Gedde-Dahl, Tobias, Protheroe, Rachel, Tischer, Johanna, Klammer, Matthias, Clausen, Johannes, Potter, Victoria, Ladetto, Marco, Tilly, Herve, Deconinck, Eric, Brecht, Arne, Müller, Lutz Peter, Heinicke, Thomas, Carrete, Juan Pio Torres, Bazarbachi, Ali, Reményi, Péter, Rubio, Marie Thérèse, Fanin, Renato, Pérez-Simón, Jose Antonio, Niels, Murawski, Diez-Martin, J., Arat, Mutlu, Hermine, Olivier, Socié, Gerard, Cornelissen, Jan, Santarone, Stella, Guyotat, Denis, Bulabois, Claude Eric, Bernasconi, Paolo, Johansson, Jan-Erik, Vrhovac, Radovan, Greinix, Hildegard, Lorenzo, José Luis López, Apte, Shashikant, Craddock, Charles, Kobbe, Guido, Zahrani, Mohsen Al, Dreger, Peter, Lange, Andrzej, Tbakhi, Abdelghani, Meijer, Ellen, Llamas, Carlos Vallejo, Santasusana, Josep Maria Ribera, Corradini, Paolo, Benedetti, Fabio, Rambaldi, Alessandro, Gandemer, Virginie, Malfuson, Jean-Valère, Kaare, Ain, Risitano, Antonio, Petrini, Mario, Selleri, Carmine, Wu, Depei, Hematology, CCA - Cancer Treatment and quality of life, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Transplantation Conditioning, MESH: Busulfan, Medizin, MESH: Graft vs Host Disease, Graft vs Host Disease, [SDV.CAN]Life Sciences [q-bio]/Cancer, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Busulfan, MESH: Hematopoietic Stem Cell Transplantation, MESH: Transplantation Conditioning, Retrospective Studies, Transplantation, Acute leukemia, MESH: Humans, MESH: Middle Aged, business.industry, Hazard ratio, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, MESH: Retrospective Studies, Retrospective cohort study, Hematology, Middle Aged, Total body irradiation, Fludarabine, Leukemia, Myeloid, Acute, Regimen, 030220 oncology & carcinogenesis, MESH: Vidarabine, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Leukemia, Myeloid, Acute, business, MESH: Whole-Body Irradiation, Vidarabine, Whole-Body Irradiation, 030215 immunology, medicine.drug
Abstract

International audience; The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two "reduced-toxicity" regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation at a dose of 8 Gy + fludarabine (TBI8Gy/Flu). In the entire study cohort (n = 518), the probabilities of overall survival (OS), leukemia-free survival (LFS), relapse and non-relapse mortality (NRM) at 2 years for Bu3/Flu and TBI8Gy/Flu were 62% vs. 72.5% (p = 0.051), 59.5% vs. 65% (p = 0.15), 30% vs. 20% (p = 0.01), and 10% vs. 14% (p = 0.18), respectively. In multivariate model for patients

Published
2021

34. Impact of positron emission tomography - computed tomography status on progression-free survival for relapsed follicular lymphoma patients undergoing autologous stem cell transplantation

Author

Eyre, Toby A., primary, Barrington, Sally F., additional, Okosun, Jessica, additional, Abamba, Clementina, additional, Pearce, Rachel M., additional, Lee, Julia, additional, Carpenter, Ben, additional, Crawley, Charles R., additional, Bloor, Adrian J.C., additional, Gilleece, Maria, additional, Nicholson, Emma, additional, Shah, Nimish, additional, Orchard, Kim, additional, Malladi, Ram, additional, and Townsend, William M., additional

Published
2022
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36. Letermovir prophylaxis in T-cell–depleted transplants: breakthrough and rebound infections in the postmarketing setting

Author

Marzolini, Maria A.V., Mehra, Varun, Thomson, Kirsty J., Tholouli, Eleni, Bloor, Adrian J.C., Parker, Anne, Lovell, Richard, Orchard, Kim, Publicover, Amy, Nicholson, Emma, Snowden, John A., Byrne, Jennifer, Khan, Anjum, Gilleece, Maria H., Errico, Gerardo, Lozano, Sara, Hurst, Erin, Duncan, Nick, Pirrie, Jennifer, Crea, Philip, Carpenter, Ben, Pagliuca, Antonio, and Peggs, Karl S.

Published
2021
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37. Autologous Stem Cell Transplantation in AL-Amyloidosis Following Yttrium-90 Labelled Anti-CD66 Monoclonal Antibody As Sole Conditioning Is Associated with Low Toxicity and Demonstrable Disease Responses

Author

Orchard, Kim H., primary, Langford, Jon, additional, Lloyd-Evans, Paul, additional, Phillips, Denise, additional, Guy, Matthew, additional, Michopoulou, Sofia, additional, Lewis, Gemma, additional, Williams, Julian, additional, Zvavamwe, Clint, additional, Hutchison, Claire, additional, Nunnick, Jane, additional, Blackwell, Amanda, additional, Chan, Pei-San, additional, Wickham, Caspar, additional, Quigley, Ann-Marie, additional, Cook, Mark, additional, Jackson, Graham, additional, Hawkins, Philip N, additional, and Wechalekar, Ashutosh D., additional

Published
2021
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41. Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy

Author

Aljurf, Mahmoud, Snowden, John A., Hayden, Patrick, Orchard, Kim H., and McGrath, Eoin

Subjects
Hematology, Oncology, Blood Transfusion Medicine, Internal Medicine, outcome analysis, structural indicators, process indicators, Hematopoietic Stem Cell Transplantation, Quality Management, Audits, Qualification and Validation, Personnel Requirements, Performance Measurement, Tracking and Traceability, Adverse Events, Quality Management Plan, Accreditation, Data Management, Training, Risk Management, JACIE, Haematology, bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJF Haematology, bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
Abstract

This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program.

Published
2021
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42. Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Author

Halter, Joerg P., Michael, W., Schüpbach, M., Mandel, Hanna, Casali, Carlo, Orchard, Kim, Collin, Matthew, Valcarcel, David, Rovelli, Attilio, Filosto, Massimiliano, Dotti, Maria T., Marotta, Giuseppe, Pintos, Guillem, Barba, Pere, Accarino, Anna, Ferra, Christelle, Illa, Isabel, Beguin, Yves, Bakker, Jaap A., Boelens, Jaap J., de Coo, Irenaeus F. M., Fay, Keith, Sue, Carolyn M., Nachbaur, David, Zoller, Heinz, Sobreira, Claudia, Pinto Simoes, Belinda, Hammans, Simon R., Savage, David, Martí, Ramon, Chinnery, Patrick F., Elhasid, Ronit, Gratwohl, Alois, and Hirano, Michio

Published
2015
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43. An open-label, multicenter phase I/IIa study evaluating the safety and clinical activity of clonal neoantigen reactive T cells in patients with advanced non-small cell lung cancer (CHIRON).

Author

Jamal-Hanjani, Mariam, primary, Greystoke, Alastair, additional, Thistlethwaite, Fiona, additional, Summers, Yvonne J., additional, Allison, Jennifer, additional, Cave, Judith, additional, Orchard, Kim, additional, Ottensmeier, Christian, additional, Middleton, Gary, additional, Khoja, Leila, additional, Grant, Michael, additional, Patel, Shreenal, additional, Robertson, Jane, additional, Peggs, Karl, additional, and Forster, Martin, additional

Published
2021
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44. Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19 : EBMT guidelines and recommendations

Author

Greco, Raffaella, Alexander, Tobias, Burman, Joachim, Del Papa, Nicoletta, de Vries-Bouwstra, Jeska, Farge, Dominique, Henes, Joerg, Kazmi, Majid, Kirgizov, Kirill, Muraro, Paolo A., Ricart, Elena, Rovira, Montserrat, Saccardi, Riccardo, Sharrack, Basil, Snarski, Emilian, Withers, Barbara, Jessop, Helen, Boglione, Claudia, Kramer, Ellen, Badoglio, Manuela, Labopin, Myriam, Orchard, Kim, Corbacioglu, Selim, Ljungman, Per, Mikulska, Malgorzata, De la Camara, Rafael, Snowden, John A., Greco, Raffaella, Alexander, Tobias, Burman, Joachim, Del Papa, Nicoletta, de Vries-Bouwstra, Jeska, Farge, Dominique, Henes, Joerg, Kazmi, Majid, Kirgizov, Kirill, Muraro, Paolo A., Ricart, Elena, Rovira, Montserrat, Saccardi, Riccardo, Sharrack, Basil, Snarski, Emilian, Withers, Barbara, Jessop, Helen, Boglione, Claudia, Kramer, Ellen, Badoglio, Manuela, Labopin, Myriam, Orchard, Kim, Corbacioglu, Selim, Ljungman, Per, Mikulska, Malgorzata, De la Camara, Rafael, and Snowden, John A.

Abstract

Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an "endemic" phase and therefore an ongoing risk within a "new normality". These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.

Published
2021
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45. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey

Author

National Institute for Health Research (UK), Ljungman, Per, Cámara, Rafael de la, Mikulska, Malgorzata, Tridello, Gloria, Aguado, Beatriz, Al Zahrani, Mohsen, Apperley, Jane, Berceanu, Ana, Martino, Rodrigo, Calbacho, M., Ciceri, Fabio, López-Corral, L., Crippa, Claudia, Fox, María‐Laura, Grassi, Anna, Jiménez, María J., Koçulu Demir, Safiye, Kwon, Mi, Vallejo Llamas, Carlos, López Lorenzo, José Luis, Mielke, Stephan, Orchard, Kim, Parody Porras, Rocío, Vallisa, Daniele, Xhaard, Alienor, Simone Knelange, Nina, Cedillo, Ángel, Kroger, Nicolaus, Piñana, José Luis, Styczynski, Jan, National Institute for Health Research (UK), Ljungman, Per, Cámara, Rafael de la, Mikulska, Malgorzata, Tridello, Gloria, Aguado, Beatriz, Al Zahrani, Mohsen, Apperley, Jane, Berceanu, Ana, Martino, Rodrigo, Calbacho, M., Ciceri, Fabio, López-Corral, L., Crippa, Claudia, Fox, María‐Laura, Grassi, Anna, Jiménez, María J., Koçulu Demir, Safiye, Kwon, Mi, Vallejo Llamas, Carlos, López Lorenzo, José Luis, Mielke, Stephan, Orchard, Kim, Parody Porras, Rocío, Vallisa, Daniele, Xhaard, Alienor, Simone Knelange, Nina, Cedillo, Ángel, Kroger, Nicolaus, Piñana, José Luis, and Styczynski, Jan

Abstract

This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0–80.3) for allogeneic, and 60.6 years (7.7–81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2–292.7) in allogeneic and 24.6 months (−0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.

Published
2021

47. Correction: Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Snowden, John A, Saccardi, Riccardo, Orchard, Kim, Ljungman, Per, Duarte, Rafael F, Labopin, Myriam, McGrath, Eoin, Brook, Nigel, de Elvira, Carmen Ruiz, Gordon, Debra, Poirel, Hélène A, Ayuk, Francis, Beguin, Yves, Bonifazi, Francesca, Gratwohl, Alois, Milpied, Noel, Moore, John, Passweg, Jakob, Rizzo, J Douglas, Spellman, Stephen R, Sierra, Jorge, Solano, Carlos, Sanchez-Guijo, Fermin, Worel, Nina, Gusi, Andreu, Adams, Gillian, Balan, Theodor, Baldomero, Helen, Macq, Gilles, Marry, Evelyne, et al, University of Zurich, and Snowden, John A

Subjects
2747 Transplantation, 10032 Clinic for Oncology and Hematology, 2720 Hematology, 610 Medicine & health
Published
2020

48. Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Snowden, John A, Saccardi, Riccardo, Orchard, Kim, et al, Schanz, U, University of Zurich, and Snowden, John A

Subjects
2747 Transplantation, 10032 Clinic for Oncology and Hematology, 2720 Hematology, 610 Medicine & health
Published
2020

50. Benchmarking of survival outcomes following haematopoietic stem cell transplantation: A review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Author

Snowden, John A; https://orcid.org/0000-0001-6819-3476, Saccardi, Riccardo, Orchard, Kim, et al, Schanz, U, Snowden, John A; https://orcid.org/0000-0001-6819-3476, Saccardi, Riccardo, Orchard, Kim, et al, and Schanz, U

Abstract

In many healthcare settings, benchmarking for complex procedures has become a mandatory requirement by competent authorities, regulators, payers and patients to assure clinical performance, cost-effectiveness and safe care of patients. In several countries inside and outside Europe, benchmarking systems have been established for haematopoietic stem cell transplantation (HSCT), but access is not universal. As benchmarking is now integrated into the FACT-JACIE standards, the EBMT and JACIE established a Clinical Outcomes Group (COG) to develop and introduce a universal system accessible across EBMT members. Established systems from seven European countries (United Kingdom, Italy, Belgium, France, Germany, Spain, Switzerland), USA and Australia were appraised, revealing similarities in process, but wide variations in selection criteria and statistical methods. In tandem, the COG developed the first phase of a bespoke risk-adapted international benchmarking model for one-year survival following allogeneic and autologous HSCT based on current capabilities within the EBMT registry core dataset. Data completeness, which has a critical impact on validity of centre comparisons, is also assessed. Ongoing development will include further scientific validation of the model, incorporation of further variables (when appropriate) alongside implementation of systems for clinically meaningful interpretation and governance aiming to maximise acceptance to centres, clinicians, payers and patients across EBMT.

Published
2020

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