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141 results on '"Orange, Joseph B."'

2. History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment

Author

Khoury, Marc A., Churchill, Nathan W., Di Battista, Alex, Graham, Simon J., Symons, Sean, Troyer, Angela K., Roberts, Angela, Kumar, Sanjeev, Tan, Brian, Arnott, Stephen R., Ramirez, Joel, Tartaglia, Maria C., Borrie, Michael, Pollock, Bruce, Rajji, Tarek K., Pasternak, Stephen H., Frank, Andrew, Tang-Wai, David F., Scott, Christopher J. M., Haddad, Seyyed Mohammad Hassan, Nanayakkara, Nuwan, Orange, Joseph B., Peltsch, Alicia, Fischer, Corinne E., Munoz, David G., and Schweizer, Tom A.

Published
2024
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5. Predicting Cognitive Impairment in Cerebrovascular Disease Using Spoken Discourse Production

Author

Roberts, Angela, Aveni, Katharine, Basque, Shalane, Orange, Joseph B., McLaughlin, Paula, Ramirez, Joel, Troyer, Angela K., Gutierrez, Stephanie, Chen, Angie, Bartha, Robert, Binns, Malcolm A., Black, Sandra E., Casaubon, Leanne K., Dowlatshahi, Dar, Hassan, Ayman, Kwan, Donna, Levine, Brian, Mandzia, Jennifer, Sahlas, Demetrios J., Scott, Christopher J. M., Strother, Stephen, Sunderland, Kelly M., Symons, Sean, and Swartz, Richard

Abstract

Purpose: Dementia due to cerebrovascular disease (CVD) is common. Detecting early cognitive decline in CVD is critical because addressing risk factors may slow or prevent dementia. This study used a multidomain discourse analysis approach to determine the spoken language signature of CVD-related cognitive impairment. Method: Spoken language and neuropsychological assessment data were collected prospectively from 157 participants with CVD as part of the Ontario Neurodegenerative Disease Research Initiative, a longitudinal, observational study of neurodegenerative disease. Participants were categorized as impaired (n = 92) or cognitively normal for age (n = 65) based on neuropsychology criteria. Spoken language samples were transcribed orthographically and annotated for 13 discourse features, across five domains. Discriminant function analyses were used to determine a minimum set of discourse variables, and their estimated weights, for maximizing diagnostic group separation. Results: The optimal discriminant function that included 10 of 13 discourse measures correctly classified 78.3% of original cases (69.4% cross-validated cases) with a sensitivity of 77.2% and specificity of 80.0%. Conclusion: Spoken discourse appears to be a sensitive measure for detecting cognitive impairment in CVD with measures of productivity, information content, and information efficiency heavily weighted in the final algorithm. [This article was written with ONDRI Investigators.]

Published
2021
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6. Sex-Related Differences in Functional Fitness Outcomes in Older Adults.

Author

Marsala, Michael J., Belfry, Shannon, Orange, Joseph B., and Christie, Anita D.

Subjects
EXERCISE tests, HUMAN reproduction, AEROBIC capacity, REFERENCE values, CROSS-sectional method, HEALTH status indicators, SEX distribution, FUNCTIONAL assessment, GENDER identity, COMPARATIVE studies, EXERCISE, MUSCLE strength, DESCRIPTIVE statistics, LONGITUDINAL method, EXERCISE therapy, OLD age
Abstract

Sex-related differences in changes in functional fitness over time were longitudinally assessed in older adults participating in a group-based multimodal exercise program. From a database, functional fitness scores were obtained for 89 older adults (71.6 ± 6.5 years old) who had completed two assessments, 5–8 years apart. Lower body strength, upper body strength, aerobic endurance, flexibility, and change of direction performances were compared over time and with normative values. Females (p =.02), but not males, had an improvement in upper body strength over time. Females were also more flexible than males at both assessments (p ≤.02). Of those who had five consecutive assessments, females were more flexible than males (p ≤.05) and had a faster change of direction ability (p <.001). When compared with normative values, our results indicate that typical time-related functional fitness loss can be attenuated with group exercise. Our results further support the need to tailor exercise prescription according to the individual. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Neuroinflammatory biomarkers in neurodegenerative disease: Insights from the ONDRI Cohort

Author

Sumra, Vishaal, primary, Dilliott, Allison Ann, additional, Frank, Andrew R, additional, Lang, Anthony E, additional, Roberts, Angela C, additional, Troyer, Angela, additional, Levine, Brian, additional, Arnott, Stephen R., additional, Tan, Brian, additional, Fischer, Corinne E., additional, Marras, Connie, additional, Kwan, Donna, additional, Munoz, Douglas, additional, Tang‐Wai, David F., additional, Finger, Elizabeth, additional, Rogaeva, Ekaterina, additional, Orange, Joseph B, additional, Ramirez, Joel, additional, Sunderland, Kelly M, additional, Zinman, Lorne, additional, Binns, Malcolm, additional, Borrie, Michael, additional, Masellis, Mario, additional, Freedman, Morris, additional, Montero‐Odasso, Manuel, additional, Ozzoude, Miracle, additional, Bartha, Robert, additional, Swartz, Richard H., additional, and Tartaglia, Carmela, additional

Published
2023
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9. Assessing the impact of falls on neuropsychiatric symptoms in patients with neurodegenerative disease

Author

Joghataie, Goldin, primary, Dilliott, Allison Ann, additional, Frank, Andrew R, additional, Lang, Anthony E, additional, Roberts, Angela C, additional, Troyer, Angela, additional, Levine, Brian, additional, Arnott, Stephen R., additional, Tan, Brian, additional, Fischer, Corinne E., additional, Marras, Connie, additional, Kwan, Donna, additional, Munoz, Douglas, additional, Tang‐Wai, David F., additional, Finger, Elizabeth, additional, Rogaeva, Ekaterina, additional, Orange, Joseph B, additional, Ramirez, Joel, additional, Sunderland, Kelly M, additional, Zinman, Lorne, additional, Binns, Malcolm, additional, Borrie, Michael, additional, Masellis, Mario, additional, Freedman, Morris, additional, Montero‐Odasso, Manuel, additional, Ozzoude, Miracle, additional, Bartha, Robert, additional, Swartz, Richard H., additional, Abrahao, Agessandro, additional, McIlroy, Bill, additional, Strong, Michael J., additional, and Tartaglia, Carmela, additional

Published
2023
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10. Perceived efficacy, feasibility, and implementation of community engaged research practices in the multi‐site SuperAging Research Initiative

Author

Rahman‐Filipiak, Annalise, primary, Maher, Amanda Cook, additional, Okonkwo, Ozioma, additional, Amador, Gabriella, additional, Bradley, Samantha, additional, Eldes, Fatima, additional, Engelmeyer, Janessa, additional, Finger, Elizabeth, additional, Goldstein, Felicia C, additional, Hunt, Nicole, additional, Lose, Sarah R, additional, McIlroy, William, additional, Morhardt, Darby J., additional, Nelson, Alexis R, additional, Van Ooteghem, Karen, additional, Orange, Joseph B, additional, Parker, Monica W, additional, Roberts, Angela C, additional, Timpo, Phyllis, additional, Trammell, Antoine R, additional, Weintraub, Sandra, additional, and Rogalski, Emily J, additional

Published
2023
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13. Transitional Care from Hospital to Cardiac Rehabilitation During COVID-19: The Perspectives of Older Adults and Their Healthcare Providers.

Author

Flores-Sandoval, Cecilia, Orange, Joseph B., Ryan, Bridget L., Adams, Tracey L., Suskin, Neville, McKelvie, Robert, Elliott, Jacobi, and Sibbald, Shannon L.

Subjects
HOSPITALS, RESEARCH, RESEARCH evaluation, TRANSITIONAL care, ATTITUDES of medical personnel, RESEARCH methodology, FAMILY support, INTERVIEWING, PATIENTS' attitudes, CARDIAC rehabilitation, DECISION making, RESEARCH funding, THEMATIC analysis, COVID-19 pandemic
Abstract

Transitional care to cardiac rehabilitation during the pandemic was a complex process for older adults, with additional challenges for decision-making and participation. This study aimed to explore the perspectives of older adults and health providers on transitional care from the hospital to cardiac rehabilitation, focusing on patient participation in decision-making. A qualitative exploratory design was used. Semi-structured interviews were conducted with 15 older adults and 6 healthcare providers. Document analysis and reflexive journaling were used to support triangulation of findings. Six themes emerged from the data, related to insufficient follow-up from providers, the importance of patients' emotional and psychological health and the support provided by family members, the need for information tailored to patients' needs and spaces for participation in decision-making, as well as challenges during COVID-19, including delayed medical procedures, rushed discharge and isolating hospital stays. The findings of this study indicated a number of potential gaps in the provision of transitional care services as reported by older adults who had a cardiovascular event, often during the first few weeks post hospital discharge. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Predictive language comprehension in Parkinson’s disease

Author

Aveni, Katharine, primary, Ahmed, Juweiriya, additional, Borovsky, Arielle, additional, McRae, Ken, additional, Jenkins, Mary E., additional, Sprengel, Katherine, additional, Fraser, J. Alexander, additional, Orange, Joseph B., additional, Knowles, Thea, additional, and Roberts, Angela C., additional

Published
2023
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15. White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

Author

Carvalho de Abreu, Daniela Cristina, Pieruccini-Faria, Frederico, Sarquis-Adamson, Yanina, Black, Alanna, Fraser, Julia, Van Ooteghem, Karen, Cornish, Benjamin, Grimes, David, Jog, Mandar, Masellis, Mario, Steeves, Thomas, Nanayakkara, Nuwan, Ramirez, Joel, Scott, Christopher, Holmes, Melissa, Ozzoude, Miracle, Berezuk, Courtney, Symons, Sean, Mohammad Hassan Haddad, Seyyed, Arnott, Stephen R, Binns, Malcolm, Strother, Stephen, Beaton, Derek, Sunderland, Kelly, Theyers, Athena, Tan, Brian, Zamyadi, Mojdeh, Levine, Brian, Orange, Joseph B, Roberts, Angela C, Lou, Wendy, Sujanthan, Sujeevini, Breen, David P, Marras, Connie, Kwan, Donna, Adamo, Sabrina, Peltsch, Alicia, Troyer, Angela K, Black, Sandra E, McLaughlin, Paula M, Lang, Anthony E, McIlroy, William, Bartha, Robert, and Montero-Odasso, Manuel

Abstract

BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (pCONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.

Published
2023

16. Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A, McLaughlin, Paula M, Abrahao, Agessandro, Black, Sandra E, Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B, Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G, Rajji, Tarek K, Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D L, Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F, Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
Psychiatry and Mental health
Abstract

Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function. Methods We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD ( N = 111), CVD ( N = 148), PD ( N = 136), FTD ( N = 50) and ALS ( N = 36). We compared the frequency and severity of individual NPS (assessed by the neuropsychiatric inventory questionnaire) across cohorts using generalized estimating equations and analysis of variance. Second, we assessed the relationship of NPS burden with instrumental (iADLs) and basic (ADLs) activities of living across cohorts using multivariate linear regression while adjusting for relevant demographic and clinical covariates. Results Frequency of NPS varied across cohorts (χ2(4) = 34.4, p < .001), with post-hoc tests showing that FTD had the greatest frequency as compared to all other cohorts. The FTD cohort also had the greatest severity of NPS ( H(4) = 34.5, p < .001). Further, there were differences among cohorts in terms of the association between NPS burden and ADLs ( F(4,461) = 3.1, p = 0.02). Post-hoc comparisons suggested that this finding was driven by the FTD group, however, the differences did not remain significant following Bonferroni correction. There were no differences among cohorts in terms of the association between NPS burden and IADLs. Conclusions NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Published
2023

17. sj-docx-2-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-2-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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18. sj-pdf-1-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-pdf-1-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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19. sj-docx-3-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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20. Evaluation of a Student-Older Adult Telephone Befriending Program to Reduce Social Isolation during the COVID-19 Pandemic: A Pilot Evaluation

Author

Ahuja, Manan, Lewis, Kaitlin, Kim, Leanne, Owais, Sawayra, Compagnone, Jordana, Fallico, Laura, Fishbein, Francine, Stefanova, Isabella, Xu, Kai Man, Boulos, Mary, Gui, Shannon, Basu, Monisha, Cooper, Tracy, Kay, Kelly, Hogan, David B., Morais, José A., Molnar, Frank, Lam, Robert E., Borrie, Michael J., Koerber, Raphaelle, Vaccarello, Linh, Ho, Allan, MacKay, Scott, Ebert, Patricia, Harbridge, Cathy, Hogan, David, Mukharyamova, Alfiya, Foster, Nicoda, Wang, Irene, Kabitsis, Pauline P., Hamelin, Mary Ann, Troung, Nga, Lee, Janny, Sinha, Samir K., Thompson, Cody, Bharadia, Morgan, Sadowski, Cheryl, Chuen, Victoria, Chan, Adrian, Alibhai, Shabbir, Chau, Vicky, Dholakia, Saumil, Bagheri, Alireza, Simpson, Alexander (Sandy), Hewitt, David, Ratcliffe, Michael, Booth, Dr Malcolm, Lafleur, Benoit, Jibb, Samantha, Gingrich, Shaen, Lane, Susan, Clarke, Jo-Anne, Fat, Guillaume Lim, Gopaul, Aquila, Pananos, Demetri, Taabazuing, Mary-Margaret, Schnarr, Lindsay, Bater, Marilyn, Dai, Serina, Freedman, Amy, Degan, Sophie Del, Forget, Marie-France, Leblanc, Julie, Desjardins, Michaël, Durand, Madeleine, Vu, Thien Tuong Minh, Nguyen, Quoc Dinh, Desmarais, Philippe, Miles, Amy, Norris, Mireille, Reppas-Rindlisbacher, Christina, Finlay, Jessica M, Mahar, Alyson, Siddhpuria, Shailee, Hallet, Julie, Rochon, Paula, Kobayashi, Lindsay C, Wong, Eric, Gormley, Jessica, Lee, Justin, Conroy, Maeve, Patterson, Christopher, Xu, Victoria YY, Sham, Rosalind, Moy, Sally, Naglie, Gary, Smith, Jagger, Mahon, Joel, Almeida, Quincy, Bherer, Louis, Burhan, Amer, Liu-Ambrose, Teresa, Middleton, Laura, Nagamatsu, Lindsay, Speechley, Mark, Montero-Odasso, Manuel, Osman, Abdelhady, Ali, Shehzad, Payen, Anaïs, Beuscart, Jean-Baptiste, Soula, Julien, Verloop, David, Defebvre, Marguerite-Marie, Dambre, Delphine, Godard-Sebillotte, Claire, Pieruccini-Faria, Frederico, Haddad, Seyyed, Cornish, Ben, McIlroy, Bill, Bartha, Rob, Investigators, All ONDRI, Searle, Samuel, Walsh, Steve, Davis, Giselle, Mercier, Tara, Rockwood, Kenneth, Davis, Daniel, Haroon, Babar, Sultana, Munira, Campbell, Karen, Jennings, Morgan, Orange, Joseph B., Knowlton, Jill, George, Armin St., Bryant, Dianne, Akter, Ripa, Kim, Kristine, Huang, Allen, Arsenault-Lapierre, Geneviève, Bui, Tammy, Sourial, Nadia, Quesnel-Vallée, Amélie, Massamba, Victoria, Rochette, Louis, Morgan, Debra, Kosteniuk, Julie, Vedel, Isabelle, Aubin, Vincent, Paquet, Steve, Durand, Pierre J., Pageau, Félix, Bharaj, Neetika, Suárez, Pablo Solla, Obrand, Jeremy, Chetrit, Jessica, Ahmad, Fayeza, Lantagne, Sarah, Morrison, David, Xue, Xiaoqing, Afilalo, Marc, Richards, Brent, Afilalo, Jonathan, Bray, Nick W, Witt, Suzanne T, Bartha, Robert, Doherty, Timothy J, Nagamatsu, Lindsay S, Almeida, Quincy J, Arsenault-Lapierre, Genevieve, Cameron, Julie, Kolomitro, Klodiana, Dalgarno, Nancy, Turnnidge, Jennifer, Pelland, Lucie, Auais, Mohammad, Carr, Frances, Morgan, Angela, Devapura, Shehani, Williams, Christina, Symon, Jennifer, Howe-Riddell, Carolyn, Miller, Angela, Boone, Jennifer, Ebbage, Kevin, Jadaviji, Shalmin, Mathura, Pamela, Charles, Lesley, Parmar, Jasneet, Suzette, Brémault-Phillips, Pike, Ashley, Dobbs, Bonnie, Tian, Peter George, Piazza, Nicolo, Goldfarb, Michael, Martucci, Giuseppe, Rudski, Lawrence, Spaziano, Marco, Morin, Jean-Francois, Lachapelle, Kevin, Langlois, Yves, D’Amico, Danielle, Yusupov, Iris, Zhu, Lynn, Lass, Jordan W., Levine, Brian, Vandermorris, Susan, Troyer, Angela K., Ewa, Vivian, Lee, Jennifer, Jones, Chris, Gutscher, Abram, Feng, Chengying, Adebero, Tony, DePaul, Vincent, Vafaei, Afshin, Norman, Kathleen, Gallibois, Molly, Rogers, Kyle, Folkins, Chris, Jarrett, Pamela, Magalhaes, Sandra, Gibson, Kirstian, Gao, Yuchen, Ottley, Katherine M., Qiao, Thomas, Myge, Ivy, Compton, Roslyn M., Wickson-Griffiths, Abigail, Hunter, Paulette V., Network, Saskatchewan Long-Term Care, Gill, Navjot, Connelly, Denise, Godwin, Bradley, Hanson, Natasha, Kervin, Emily, Skerry, Leanne, McCloskey, Rose, Hassanabadi, Nazila, Berger, Claudie, Papaioannou, Alexandra, Cheung, Angela M, Rahme, Elham, Leslie, William D, Goltzman, David, Morin, Suzanne, Hogeveen, Sophie, Heckman, George, Milne, Kelly, Hirdes, John, Horne, Natalie, Marshall, Emily, Andrew, Melissa, Hunter, Susan, Somerville, Lyndsay, Lanting, Brent, Ivo, Jessica, Pitre, Teresa, Faisal, Sadaf, Antunes, Kristen, Oda, Kasumi, Patel, Tejal, Jacob, Gabriella, Sherwood, Malcolm, Malik, Shabhaz, Baker, Jacquie, Bhangu, Jaspreet, Khoury, Lara, Moors, Joy, Lampron, Jacynthe, Figueira, Sonshire, Nemnom, Marie-Joe, Eagles, Debra, Koop, Jennifer, Lee, Linda, Hillier, Loretta M., Gregg, Susie, Hickman, Kathy, Agla, Caitlin, Carducci, Jillian, Skimson, Kara, Dillon-Martin, Sharon, Kuzych, Lissa, Beuermann, Lindsay, Parikh, Ruchi, Lee, Catherine, Lee, Ahreum, McArthur, Caitlin, Ioannidis, George, Adachi, Jonathan D, Griffith, Lauren E, Thabane, Lehana, Giangregorio, Lora, Morin, Suzanne N, Madden, Kenneth, Feldman, Boris, Arishenkoff, Shane, Meneilly, Graydon, Mah, Jasmine, Godin, Judith, Stevens, Susan, Keefe, Janice, Sun, Michael, Goodwin, Josh, Cheung, Bonnie, von Maltzahn, Maia, Mailhot, Tanya, Clausen, Christina, Crump, Laura, Leblanc, Marie-Eve, Sanzone, Lia, Marr, Sharon, Doherty, Michelle, Siemon, Jennifer, Hillier, Loretta, Milroy, Desmond, Marrone, Erica, Maalouf, Mona, Moorhouse, Paige, Shetty, Nabha, Mallery, Laurie, Miller, Ashley, VonMaltzahn, Maia, Naug, Anne Marie Krueger, Tinning, Amanda, Buckler, Melissa, Stasiulis, Elaine, Sandhu, Harvir, Brookes, Jahnel, Vrkljan, Brenda, Mariano, Claudia, Gélinas, Isabelle, Byszewski, Anna, Rapoport, Mark J., Sanford, Sarah, Bédard, Michel, Belchior, Patricia, Crizzle, Alexander, Marshall, Shawn, Rapoport, Mark, Nene, Sofia, Bennett, Roxanne, Morin, Suzanne N., Nixon, Lara, Sampson, Megan, Punungwe, Fadzai Moreblessing, Kelly, Martina, Nuique, Kate, Papillon-Ferland, Louise, Castonguay, Valérie, Anderson, Sharon, Pollard, Cheryl, Poole, Lisa, Leslie, Myles, McGhan, Gwen, Weir, Carolyn, Pooler, Charlotte, Stickney-Lee, Jennifer, Shapkin, Kimberly, Peyrusqué, Eva, Kergoat, Marie-Jeanne, Bolduc, Aline, Buckinx, Fanny, Law, Caroline, Veillette, Nathalie, Fonseca, Raquel, Aubertin-Leheudre, Mylène, Quan, Samuel, Menec, Verena, O’Connell, Megan, Cloutier, Denise, Newall, Nancy, Tate, Robert, John, Philip St., Qureshi, Natasha, Djekic-Ivankovic, Maria, Wall, Michelle, Berry, Gregory, Mayo, Nancy, Gélinas, Céline, Funnell, Larry, Racey, Megan, Markle-Reid, Maureen, Fitzpatrick-Lewis, Donna, Ali, Muhammad Usman, Gagné, Hélène, Ploeg, Jenny, Sztramko, Richard, Harrison, Lisa, Sherifali, Diana, Sacco, Veronica, Stolee, Paul, Boscart, Veronique, MacEachen, Ellen, Malik, Shabaz, Borrie, Micheal, Fogarty, Jennifer, Savage, Rachel, Sirisegaram, Luxey, Thain, Jenny, Diachun, Laura, Lingard, Lorelei, Cristancho, Sayra, Triscott, Jean, Huang, James, Moores, David, Tian, Peter George Jaminal, and Cerna, Judith

Subjects
Abstracts, Eligible for the Edmund V. Cowdry Award, Finalists for the Willard and Phoebe Thompson Award, Posters, Eligible for the Réjean Hébert Canadian Institutes of Health Research - Institute on Aging Prize, Eligible for the Dr. Jack & Dr. ASA Award
Published
2021

21. Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.

Author

Riek, Heidi C., Brien, Donald C., Coe, Brian C., Huang, Jeff, Perkins, Julia E., Yep, Rachel, McLaughlin, Paula M., Orange, Joseph B., Peltsch, Alicia J., Roberts, Angela C., Binns, Malcolm A., Wendy Lou, Abrahao, Agessandro, Arnott, Stephen R., Beaton, Derek, Black, Sandra E., Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E., and Frank, Andrew R.

Published
2023
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22. Geriatric dementia care at Ontario Shores: A new model of care

Author

Viau, Katelynn, Yaddaden, Amel, Lussier, Maxime, Bier, Nathalie, Earle, Julie, Duff-Woskosky, Andra, Bartfay, Wally, Desai, Chaitali, Zavitz, Karen, Horsburgh, Sheri, Gamble, Brenda, Lee, Linda, Hillier, Loretta M., Patel, Tejal, Molnar, Frank, Clarke, Jo-Anne, Borrie, Michael, Cammer, Allison, Morgan, Debra, Whiting, Susan, de Vos, Maya, Henri-Bhargava, Alexandre, Votova, Kristine, Delmar, Paul, Kerchner, Geoffrey A, Wang, Guoqiao, Bateman, Randall, Klein, Gregory, Andjelkovic, Mirjana, Abi-Saab, Danielle, Bullain, Szofia, Montoya, Alonso, Fontoura, Paulo, Doody, Rachelle, Tai, Elaine, Harvey, David, Hofmann, Carsten, Ristic, Smiljana, Rehal, Sunita, Voyle, Nicola, Baudler, Monika, Verreault, Phylicia, Rousseau, François, Keller, Evelyn, Simard, Alexandra, Azouaou, Nassima, Jarboui, Manel, Talleria, Lorraine, Duguay, Johanne, Mérette, Chantale, Labbé, Annie, de Arco, Rossana Peredo Nunez, Yous, Marie-Lee, Ploeg, Jenny, Kaasalainen, Sharon, Martin, Lori Schindel, Palumbo, Mary Val, Rambur, Betty, McKenna, Lori, Voyer, Philippe, Allaire, Émilie, Li, Bing, Thaut, Michael, Yogaparan, Thirumagal, Shanmuganathan, Thirunathan, Vickneswaran, Anicha, Sriharan, Sruthy, DeMarco, Mari L., Hsiung, Ging-Yuek Robin, Best, John R., Chertkow, Howard, Gauthier, Serge, Karlawish, Jason, Feldman, Howard, Spaner, Caroline, Christie, Brian, Musteata, Stela, Gawryluk, Jodie, Hofer, Scott, Henri-Bhargava, Alex, Kenny, Rebecca, Elliot, Valerie, Kosteniuk, Julie, Chow, Amanda Froehlich, Bayly, Melanie, O’Connell, Megan E., Kortzman, August, O’Connell, Megan, Kirk, Andrew, Conn, David, Sokoloff, Lisa, Feldman, Sid, Chau, James, Moser, Andrea, Lingum, Navena, Gingrich, Shaen, Shaikh, Salma, Rabheru, Kiran, Cassidy, Keri-Leigh, Checkland, Claire, Parsons, Daria, Massie, Ariane S., Mitchell, Julie Spence, Aksenchuk, Sophia, Lindsay, Barbara, Howard, Maria, Shaw, Courtney, Armitage, Gerrard, Capstick, Andrea, McNeil, Heather, Holyoke, Paul, Vines, Chanile, Giosa, Justine, Khan, Bilal, Shultz, Mary, BEAUCHET, Olivier, Sekhon, Harmehr, Allali, Gilles, Montembeault, Maxime, Brodeur, Catherine, Macoir, Joël, Maxwell, Colleen, Maclagan, Laura, Campitelli, Michael, Yao, Shenzhen, Dharma, Christoffer, Sherin, Tracey, Hogan, David, Bronskill, Susan, Ivo, Jessica, Faisal, Sadaf, McDougall, Aidan, Bauer, Jillian, Pritchard, Sarah, Chang, Feng, Mehta, Deval, Syed, Ali, Carter, Caitlin, Sharma, Shaambhavi, Nagge, Jeff, Naglie, Gary, Stasiulis, Elaine, Yamin, Stephanie, Vrkljan, Brenda, Tuokko, Holly, Sanford, Sarah, Porter, Michelle, Polgar, Jan, Myers, Anita, Moorhouse, Paige, Mazer, Barbara, Marshall, Shawn, Gélinas, Isabelle, Crizzle, Alexander, Byszewski, Anna, Belchior, Patricia, Bédard, Michel, Rapoport, Mark, Minish, Duane, Yetman, Linda, Stephenson, Margaret, McCloskey, Rose, Agbaku, Mansa, Jarrett, Pamela, Cavanagh, Jennifer, Loncar, Adele, Demers, Vickie, Gobessi, Linda, Lodha, Vinay, Scerbe, Andrea, Astell, Arlene, DesRoches, Andrea, Panyavin, Ivan, Feltz, Nick, Wittich, Walter, Aubin, Gabrielle, Hogan, Mariah, Swaminathan, Swathi, Altschuler, Aviva, Murphy, Kelly, Guthrie, Dawn, Williams, Nicole, Campos, Jennifer, Mick, Paul, Orange, Joseph B., Pichora-Fuller, M. Kathleen, Savundranayagam, Marie Y., Phillips, Natalie A., Giroud, Nathalie, Pichora-Fuller, Kathy, Al-Yawer, Faisal, Rehan, Sana, Phillips, Natalie, Beauchet, Olivier, Niculescu, Iulia, Iaboni, Andrea, Quirt, Hannah, Penko, Marion, Tsokas, Mario, Marshall, Cecelia, Flint, Alastair, McGilton, Katherine, O’Connell, Megan E, Stewart, Norma J, Seitz, Dallas, Daku, Jean, Hack, Tracy, Hoium, Faye, Kennett-Russill, Deb, Sauter, Kristen, Holley, Joanna, Wimhurst, Christine, Katchaluba, Janet, Mitchell, Debbie, Severina, Elmira, Dallaire-Théroux, Caroline, Saikali, Stéphan, Duchesne, Simon, Sivananthan, Saskia, Mirza, Saira, Saeed, Usman, Knight, Jo, Ramirez, Joel, Stuss, Donald, Yu, Di, Swardfager, Walter, Keith, Julia, Nestor, Sean, Black, Sandra, Masellis, Mario, Joyal, Marilyne, Kotz, Sonja A., Lenglos, Christophe, Renauld, Emmanuelle, Wilson, Maximiliano A., Fecteau, Shirley, Appel, Lora, Kisonas, Erika, Appel, Eva, Bartlett, Deanna, Klein, Jennifer, Rosenberg, Jarred, Smith, Christopher, Ali, Suad, Narang, Tanya, Wiseman, Micaela, Ein, Natalie, Orchanian-Cheff, Ani, Rylett, Jane, Hogan, David B., Rockwood, Kenneth, Dixon, Roger, Sun, Winnie, Hawkins, Stacey A., Awde, Carolee, Kay, Kelly, Huntsbarger, Deana, Ferrier, Erin, Sourial, Nadia, Arsenault-Lapierre, Genevieve, McAiney, Carrie, Vedel, Isabelle, Ingram, K. Jennifer, Frank, Andrew, Sabra, Iman, Wallace, Bruce, Breau, Michael, Sweet, Lisa, Goubran, Rafiq, Knoefel, Frank, Goubran, Rafik, Stroulia, Eleni, Ault, Laura, Kecskemet, Judith, Guseva, Elena, Lungu, Ovidiu, Goldman, Sondra, Wilchesky, Machelle, Johri, Fozia, Turner, Angelese, Lavoie, Monica, Tang-Wai, David, Leonard, Carol, Graham, Naida L., Rochon, Elizabeth, Middleton, Laura, Herrmann, Nathan, Oh, Paul, Regan, Kayla, Bechard, Lauren, Lanctôt, Krista, Freeman, Shannon, Pettersen, Jacqueline, Tomasone, Jennifer, Dupuis, Sherry, Giangregorio, Lora, Ferris, Rebecca, Stultz, Tim, Mallard, Kirsten, Campbell, Elaine, Chatterjee, Atri, Mackenzie, Ian, Reinshagen, Veronica Hirsh, Ducharme, Blake, Mousavi, Ali, Gill, Sascha, Mouches, Pauline, Wang, Meng, Rajasheskar, Deepthi, MacMaster, Frank, Forkert, Nils, Smith, Eric, Ismail, Zahinoor, Varatharajah, Breni, Camicioli, Richard, Gee, Myrlene, Zwiers, Angela, Sekhon, Ramnik, Charlton, Anna, Arsenault-Lapierre, Geneviève, Ingram, Jennifer, Hawkins, Stacey, Mousavi, SeyedAli, Mackenzie, Ian R. A., Hirsh-Reinshagen, Veronica, Hsiung, Ging-Yuek. R., Gillingham, Susan M.E., Anderson, Nicole D., Alain, Claude, Georgievski, Georgi, Alfaro, Leonardo, McClenaghan, Meridith, Soares, Daniela, Matheson, Maureen, Stanoulis, Krisanne, Boyle, Daniel, Chau, Linh, Pelc, Jordan, Snash, Nadia, Byrne, Joanne, Elalouf, Karine, Alfaro, Andrea Urqueta, Johnson, Aaron, Marinier, Julie-Andrée, Kehayia, Eva, Gagné, Jean-Pierre, Murphy, Caitlin, Ellen, Ruth, Flowers, Brandi, Boulton, Karen Lee, Subotic, Arsenije, McCreary, Cheryl R., Nguyen, Amanda, Saad, Feryal, Alvarez, Ana, Beaudin, Andrew E, Pike, Bruce, Smith, Eric E, Hu, Sophie, Patten, Scott, Fick, Gordon, Sapkota, Shraddha, Mirza, Saira Saeed, Scott, Christopher J., Stuss, Donald T., Black, Sandra E., Le Blanc, Gabriella, Ducharme, Simon, Meilleur-Durand, Synthia, Lévesque, Marianne, St-Onge, Frédéric, Cunnane, Stephen, Villeneuve, Sylvia, Callahan, Brandy, Laforce, Robert, Cetin-Sahin, Deniz, Cummings, Greta G., Schuster, Tibor, Karanofsky, Mark, De Jesus, Belmir J., Cassani, Raymundo, Cecchi, Marco, Fadem, K. C., McGeown, William J., Falk, Tiago H., Chu, Charlene, Zdaniuk, Natalia, Wang, Rosalie, Ouellet, Marie-Christine, Cassivi-Joncas, Alison, Godard-Sebillotte, Claire, Rochette, Louis, Pelletier, Eric, Strumpf, Erin, Margo-Dermer, Eva, Silver, Hilah, Vafaei, Rod, Fok, Alice C, Hsiung, Ging-Yuek R., Ursenbach, Jake, Bethell, Jennifer, Neuman, Mark D, Bateman, Brian T, Hill, Andrea, Wunsch, Hannah, Ritchie, Kim, Cramm, Heidi, Aiken, Alice, Donnelly, Catherine, Goldie, Katie, Delara, Mahin, Ozzoude, Miracle, Varriano, Brenda, McLaughlin, Paula, Troyer, Angela, Bartha, Robert, Symons, Sean, Kwan, Donna, Tan, Brian, Swartz, Richard H., Saposnik, Gustavo, Tartaglia, Maria C., Ahuja, Manan, Siddhpuria, Shailee, Gormley, Jessica, Reppas, Christina, Wong, Eric, Lee, Justin, Patterson, Christopher, Walker, Jennifer, Warry, Wayne, Blind, Melissa, Allaby, Cheryl, Pitawanakwat, Karen, Zhao, Yantao, Lemieux, Andrine, Jacklin, Kristen, Crowshoe, Lindsay, Boehme, Gail, McKenna, Betty, Boyling, Elaine, Webkamigad, Sharlene, Bigeagle, Louise, Akan, Nicole, Wallace, Lindsay, Theou, Olga, Bennett, David, Darvesh, Sultan, Kirkland, Susan, Fisk, John, Andrew, Melissa, Cullen, Stephanie, Carroll, Susan, Mahon, Joel, Sarquis-Adamson, Yanina, Montero-Odasso, Manuel, Sharma, Nabina, Beaton, Derek, Roberts, Angela, Munoz, Doug, Swartz, Richard, Breen, David, Lang, Anthony, Fischer, COrrine, Fischer, Corrine, Kumar, Sanjeeve, Freedman, Morris, Finger, Elizabeth, Zinman, Lorne, Grimes, David A., Sunderland, Kelly M., Binns, Malcolm A., Strother, Stephen C., Mandzia, Jennifer, Orange, JB, Tartaglia, Carmela, El Shatshat, Amna, Rao, Praveen P.N., Teves, Julia, Bodkin, R Jack, Ho, Joanne M-W, Mehdizadeh, Sina, Dolatabadi, Elham, Ng, Kimberley-Dale, Arora, Twinkle, Jizmejian, Melody, Mansfield, Avril, Taati, Babak, Levy, Jake, Savard, Melissa, Pascoal, Tharick, Soucy, Jean-Paul, Rosa-Neto, Pedro, Martins, Felicia, Waller, Shannon, Flora, Parminder, Morland, Chris, Donovan, Steve, Fels, Deborah, Desai, Shital, Boger, Jennifer, Shashtri, Karan, Persaud, Deanna, Marashi, Sheida, Nedlund, Ann-Charlotte, Mäki-Petäjä-Leinonen, Anna, Nygård, Louise, Issakainen, Mervi, ryd, Charlotta, Pan, Yuhan, Joddrell, Phil, Dove, Erica, Owens, Hollis, Park, Elly, Liu, Lili, Kaufman, David, Simonian, Natalie, Chen, Ying, Sunderland, Kelly, Fraser, Julia, Swartz, Rick, Strother, Stephen, Legrand, Diego, Roberge, Pasquale, Vanasse, Alain, Bocti, Christian, Pirrie, Lorraine, Gray, Carolyn Steele, Nippak, Pria, Coughlan, Dave, Teselink, Johannes, Hermann, Nathan, Rasquinha, Fawn, Lanctot, Krista, Webber, Jodi, Woo, Kevin, Chamoun, Elicia, Coulombe, Valérie, Sellami, Leila, Paquette-Raynard, Emmanuelle, Gardner, Sandra, van Zon, Lorraine, Moy, Sally, Sidrak, Mariam, Sternhill, Janis, Feldman, Sidney, Karuza, Jurgis, Berall, Anna, Thomas, Neil, Mattek, Nora, Riley, Thomas, Reynolds, Christina, Marcoe, Jennifer, Sharma, Nicole, Kaye, Jeffrey, Jagtap, Shreya, Rotenberg, Shlomit, Vandermorris, Susan, Anderson, ND, Dawson, DR, Chater, Catherine, Soor, Jaspreet, Ji, Xiang, Koo, Morgan, Compagnone, Jordana, Kertes, Peter, Juby, Angela, Mager, Diana, Davis, Christopher, Jay, David, Blackburn, Toni, Brocks, Dion, Lee, Hyunwoo, Wiggermann, Vanessa, Rauscher, Alexander, Lam, Kevin, Tam, Roger, Popuri, Karteek, Beg, Mirza Faisal, Jacova, Claudia, Sossi, Vesna, Bindra, Jessica, Bouvier, Liziane, Monetta, Laura, Vitali, Paolo, Martel-Sauvageau, Vincent, Godin, Judith, McNeil, Shelly, McElhaney, Janet, Laughton, Thomas, Ho, Joanne, Tung, Jennifer, Dubé, Joseph B., Lin, Tianzhen, Best, Sarah, Truemner, Julia, Sargeant, Patricia L., Borrie, Michael J., Fogarty, Jennifer, Bassi, Nimi, Di Prospero, Cynthia, Whitehead, Victor, Pilon, Randi, Wong, Timothy, Elhayek, Nada, Dasgupta, Monidipa, Davis, Daniel, ORegan, Niamh, Kröger, Edeltraut, Furrer, Daniela, Wilcheski, Machelle, Morin, Michèle, Carmichael, Pierre-Hugues, Champoux, Nathalie, Monette, Johanne, Giguère, Anik, Aubin, Michèle, Durand, Pierre, Whiteside, Jena, Mele, Bria, Merrikh, Daria, Goodarzi, Zahra, Seary, Judith Anne, Bulley, Heather, Diciacca, Allison, Esseltine, Julia, Gaiger, Erin, Jankovic, Ivana, Mackenzie, Stephanie, McBride, Meghan, Knopp-Sihota, Jennifer A., Hoben, Mathias, Poss, Jeffrey W., Rachor, Geoffrey S., Estabrooks, Carole A., and Iroanyah, Ngozi

Subjects
Abstracts: Posters
Published
2020

24. Behavioral Markers for Deficits in Speed of Processing in Cerebrovascular Disease

Author

Chen, Ying, primary, Sunderland, Kelly M, additional, Khoo, Yuelee, additional, McLaughlin, Paula M, additional, Kwan, Donna, additional, Fraser, Julia, additional, Ramirez, Joel, additional, Binns, Malcolm A, additional, Arnott, Stephen R, additional, Beaton, Derek, additional, Brien, Donald C, additional, Casaubon, Leanne K, additional, Coe, Brian C, additional, Cornish, Benjamin, additional, Dowlatshahi, Dariush, additional, Hassan, Ayman, additional, Levine, Brian, additional, Lou, Wendy, additional, Mandzia, Jennifer, additional, McIlroy, William, additional, Montero-Odasso, Manuel, additional, Ooteghem, Karen Van, additional, Orange, Joseph B, additional, Peltsch, Alicia J, additional, Pieruccini-Faria, Frederico, additional, Raamana, Pradeep Reddy, additional, Roberts, Angela C, additional, Sahlas, Demetrios, additional, Saposnik, Gustavo, additional, Strother, Stephen C, additional, Swartz, Richard H, additional, Troyer, Angela K, additional, and Munoz, Doug M, additional

Published
2021
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26. Analyzing Mobility Patterns of Older Adults with Dementia Using GPS Technology

Author

Banihashemi, M. Amin, Sapkota, Shraddha, Bronskill, Susan E., Stuss, Donald T., Black, Sandra E., Bayat, Sayeh, Naglie, Gary, Rapoport, Mark, Ye, Bing, Stasiulis, Elaine, Mihailidis, Alex, Maxwell, Selena P., Cash, Meghan K., Darvesh, Sultan, Teper, Matthew Hacker, Hudon, Catherine, Vedel, Isabelle, Yang, Xin Qiang, Khanassov, Vladimir, Guseva, Elena, Lungu, Ovidiu, Goldman, Sondra, Wilchesky, Machelle, Tam, Angela, Dansereau, Christian, Itturia-Medina, Yasser, Urchs, Sebastian, Orban, Pierre, Breitner, John, Bellec, Pierre, Benhajali, Yassine, Spiers, Helen, Badhwar, AmanPreet, Trouille, Laura, Wallace, Lindsay, Theou, Olga, Godin, Judith, Rockwood, Kenneth, Andrew, Melissa, Starblanket, Danette, Bourassa, Carrie, Godard-Sebillotte, Claire, Sourial, Nadia, Rochette, Louis, Hardouin, Marine, Pelletier, Eric, Strumpf, Erin, Ruthirakuhan, Myuri, Herrmann, Nathan, Andreazza, Ana C., Gallagher, Damien, Verhoeff, Nicolaas Paul L.G., Lanctôt, Krista L., Trenaman, Shanna C., Andrew, Melissa K., Goralski, Kerry B., McLean, Allen, Morgan, Debra, Kosteniuk, Julie, O’Connell, Megan, Bayly, Melanie, Chow, Amanda Froehlich, Elliot, Valerie, Osgood, Nathaniel, Collin-Verreault, Yannik, Chouinard, Isabelle, Vogel, Jacob, Potvin, Olivier, Duchesne, Simon, Mirza, Saira Saeed, Ramirez, Joel, Lanctôt, Krista, Masellis, Mario, Kozyrev, Natalie, Albers, Shawn, Yang, Jennifer, Prado, Vania F., Rylett, R. Jane, Dekaban, Gregory A., McFall, G. Peggy, Dieumengarde, Louis, Drouin, Shannon, Camicioli, Richard, Dixon, Roger A., Adlimoghaddam, Aida, Perez, Claudia, Stortz, Greg, Djordjevic, Jelena, Snow, Wanda M., Goertzen, Andrew L, Ko, Ji Hyun, Albensi, Benedict C, Watson, Erin, Osman, Meric, Osman, Beliz Acan, O’Connell, Megan E., Kirk, Andrew, Stewart, Norma, Cammer, Allison, Innes, Anthea, Smith, Eric E., Barber, Philip A., Field, Thalia S., Frayne, Richard, Ganesh, Aravind, Hachinski, Vladimir, McCreary, Cheryl R., Pantoni, Leonardo, Sahlas, Demetrios J., Sharma, Mukul, Swartz, Richard H., Corbett, Dale, Yamin, Stéphanie, Vrkljan, Brenda, Tuokko, Holly, Sanford, Sarah, Porter, Michelle, Polgar, Jan, Myers, Anita, Moorhouse, Paige, Molnar, Frank, Mazer, Barbara, Marshall, Shawn, Gélinas, Isabelle, Crizzle, Alexandra, Byszewski, Anna, Belchior, Patricia, Bédard, Michel, Liu, Lili, Hollinda, Kara, Kaufman, David, Astell, Arlene, Daum, Christine, Stewart, Norma J., Seitz, Dallas, Holroyd-Leduc, Jayna, Daku, Jean, Hack, Tracy, Hoium, Faye, Kennett-Russill, Deb, Sauter, Kristen, Bronskill, Susan, Etches, Jacob, Guthrie, Dawn M., Williams, Nicole, Campos, Jennifer, Mick, Paul, Orange, Joseph B., Pichora-Fuller, M. Kathleen, Phillips, Natalie A., Savundranayagam, Marie, Wittich, Walter, Arsenault-Lapierre, Genevieve, Bergman, Howard, Tadley, Jaspaul, Buzatto, Adriana Zardini, Mung, Dorothea, Bajwa, Barinder, and Li, Liang

Subjects
Abstracts, CCNA Investigator Abstracts, I. Masters Students, III. Postdoctoral Fellows, II. MD, MD/PhD, or PhD Students
Published
2019

27. Quality home care for persons living with dementia: Personal support workers' perspectives in Ontario, Canada.

Author

Breen, Rachel, Savundranayagam, Marie Y., Orange, Joseph B., and Kothari, Anita

Subjects
TREATMENT of dementia, CAREGIVER attitudes, MEDICAL quality control, TEAMS in the workplace, CAREGIVERS, HOME care services, ATTITUDES of medical personnel, RESEARCH methodology, UNLICENSED medical personnel, INTERVIEWING, PATIENT-centered care, DEMENTIA patients, QUALITATIVE research, LABOR supply, DEMENTIA, ACCESS to information, DESCRIPTIVE statistics, CONTENT analysis, PATIENT education
Abstract

There is a global need to understand how the quality of home care for persons living with dementia is perceived by their most frequent formal caregivers, personal support workers (PSW), especially given the expected rise in the prevalence of dementia. The aim of this study was to explore the perceptions of PSW regarding what constitutes quality home care for persons with dementia. Qualitative content analysis was undertaken to interpret semi‐structured interviews with PSW (N = 15). Study findings indicate that quality home care is perceived to be (1) person‐centered; (2) provided by PSW with dementia‐specific education and training; (3) facilitated by specific PSW experiences, abilities and characteristics; (4) enhanced by accessible information, services and education for persons with dementia and their caregivers; (5) provided by an inclusive dementia care team; and (6) facilitated by organisational supports and respect. However, findings also indicated differences in what PSW perceive as quality home care versus what they are experiencing when providing care for persons with dementia. Participants advocated for increased supports to them through ongoing dementia‐specific education and training, increased teamwork among care providers, increased wages, sufficient and qualified staffing, and increased exchange of client information. The findings highlight the importance of exploring front‐line workers' perspectives and how they can help revise current healthcare policies and inform future policy development. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Predictive language comprehension in Parkinson’s disease

Author

Aveni, Katharine, primary, Ahmed, Juweiriya, additional, Borovsky, Arielle, additional, McRae, Ken, additional, Jenkins, Mary, additional, Sprengel, Katherine, additional, Fraser, Alex, additional, Orange, Joseph B., additional, Knowles, Thea, additional, and Roberts, Angela, additional

Published
2021
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30. A tutorial on multiblock discriminant correspondence analysis (MUDICA): a new method for analyzing discourse data from clinical populations

Author

Williams, Lynne J., Abdi, Herve, French, Rebecca, and Orange, Joseph B.

Subjects
Communicative disorders -- Care and treatment, Medical research -- Methods, Medicine, Experimental -- Methods, Speech therapy -- Methods, Qualitative research -- Methods, Health
Abstract

Purpose: In communication disorders research, clinical groups are frequently described based on patterns of performance, but researchers often study only a few participants described by many quantitative and qualitative variables. These data are difficult to handle with standard inferential tools (e.g., analysis of variance or factor analysis) whose assumptions are unfit for these data. This article presents multiblock discriminant correspondence analysis (MUDICA), which is a recent method that can handle datasets not suited for standard inferential techniques. Method: MUDICA is illustrated with clinical data examining conversational trouble-source repair and topic maintenance in dementia of the Alzheimer's type (DAT). Seventeen DAT participant/spouse dyads (6 controls, 5 participants with early DAT, 6 participants with moderate DAT) produced spontaneous conversations analyzed for co-occurrence of trouble-source repair and topic maintenance variables. Results: MUDICA found that trouble-source repair sequences and topic transitions are associated and that patterns of performance in the DAT groups differed significantly from those in the control group. Conclusion: MUDICA is ideally suited to analyze language and discourse data in communication disorders because it (a) can identify and predict clinical group membership based on patterns of performance, (b) can accommodate few participants and many variables, (c) can be used with categorical data, and (d) adds the rigor of inferential statistics. KEY WORDS: multiblock discriminant correspondence analysis, discourse, qualitative data analysis, discriminant analysis, inferential tool, In clinical research, it is necessary to identify the patterns of performance that discriminate clinical groups. Yet, speech and language researchers are often faced with the problem of finding a [...]

Published
2010
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31. Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative.

Author

Beaton, Derek, McLaughlin, Paula M., Orange, Joseph B., Munoz, Douglas P., Mandzia, Jennifer, Abrahao, Agessandro, Binns, Malcolm A., Black, Sandra E., Borrie, Michael, Dowlatshahi, Dar, Freedman, Morris, Fischer, Corinne E., Finger, Elizabeth C., Frank, Andrew, Grimes, David, Hassan, Ayman, Kumar, Sanjeev, Lang, Anthony Edward, Levine, Brian, and Marras, Connie

Subjects
CEREBROVASCULAR disease, ACTIVITIES of daily living, PSYCHOLOGY of caregivers, RESEARCH funding, FRONTOTEMPORAL dementia, NEURODEGENERATION
Abstract

Objectives: Caregiving burdens are a substantial concern in the clinical care of persons with neurodegenerative disorders. In the Ontario Neurodegenerative Disease Research Initiative, we used the Zarit's Burden Interview (ZBI) to examine: (1) the types of burdens captured by the ZBI in a cross-disorder sample of neurodegenerative conditions (2) whether there are categorical or disorder-specific effects on caregiving burdens, and (3) which demographic, clinical, and cognitive measures are related to burden(s) in neurodegenerative disorders?Methods/design: N = 504 participants and their study partners (e.g., family, friends) across: Alzheimer's disease/mild cognitive impairment (AD/MCI; n = 120), Parkinson's disease (PD; n = 136), amyotrophic lateral sclerosis (ALS; n = 38), frontotemporal dementia (FTD; n = 53), and cerebrovascular disease (CVD; n = 157). Study partners provided information about themselves, and information about the clinical participants (e.g., activities of daily living (ADL)). We used Correspondence Analysis to identify types of caregiving concerns in the ZBI. We then identified relationships between those concerns and demographic and clinical measures, and a cognitive battery.Results: We found three components in the ZBI. The first was "overall burden" and was (1) strongly related to increased neuropsychiatric symptoms (NPI severity r = 0.586, NPI distress r = 0.587) and decreased independence in ADL (instrumental ADLs r = -0.566, basic ADLs r = -0.43), (2) moderately related to cognition (MoCA r = -0.268), and (3) showed little-to-no differences between disorders. The second and third components together showed four types of caregiving concerns: current care of the person with the neurodegenerative disease, future care of the person with the neurodegenerative disease, personal concerns of study partners, and social concerns of study partners.Conclusions: Our results suggest that the experience of caregiving in neurodegenerative and cerebrovascular diseases is individualized and is not defined by diagnostic categories. Our findings highlight the importance of targeting ADL and neuropsychiatric symptoms with caregiver-personalized solutions. [ABSTRACT FROM AUTHOR]

Published
2022
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35. The Ontario Neurodegenerative Disease Research Initiative

Author

Sunderland, Kelly M., primary, Beaton, Derek, additional, Arnott, Stephen R., additional, Kleinstiver, Peter, additional, Kwan, Donna, additional, Lawrence-Dewar, Jane M., additional, Ramirez, Joel, additional, Tan, Brian, additional, Bartha, Robert, additional, Black, Sandra E., additional, Borrie, Michael, additional, Brien, Donald, additional, Casaubon, Leanne K., additional, Coe, Brian C., additional, Cornish, Benjamin, additional, Dilliott, Allison A., additional, Dowlatshahi, Dar, additional, Finger, Elizabeth, additional, Fischer, Corinne, additional, Frank, Andrew, additional, Fraser, Julia, additional, Freedman, Morris, additional, Greenberg, Barry, additional, Grimes, David A., additional, Hassan, Ayman, additional, Hatch, Wendy, additional, Hegele, Robert A., additional, Hudson, Christopher, additional, Jog, Mandar, additional, Kumar, Sanjeev, additional, Lang, Anthony, additional, Levine, Brian, additional, Lou, Wendy, additional, Mandzia, Jennifer, additional, Marras, Connie, additional, McIlroy, William, additional, Montero-Odasso, Manuel, additional, Munoz, David G., additional, Munoz, Douglas P., additional, Orange, Joseph B., additional, Park, David S., additional, Pasternak, Stephen H., additional, Faria, Frederico Pieruccini-, additional, Rajji, Tarek K., additional, Roberts, Angela C., additional, Robinson, John F., additional, Rogaeva, Ekaterina, additional, Sahlas, Demetrios J., additional, Saposnik, Gustavo, additional, Scott, Christopher J.M., additional, Seitz, Dallas, additional, Shoesmith, Christen, additional, Steeves, Thomas D.L., additional, Strong, Michael J., additional, Strother, Stephen C., additional, Swartz, Richard H., additional, Symons, Sean, additional, Tang-Wai, David F., additional, Tartaglia, Maria Carmela, additional, Troyer, Angela K., additional, Turnbull, John, additional, Zinman, Lorne, additional, McLaughlin, Paula M., additional, Masellis, Mario, additional, and Binns, Malcolm A., additional

Published
2020
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36. Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario Neurodegenerative Disease Research Initiative

Author

Beaton, Derek, primary, McLaughlin, Paula M., additional, Orange, Joseph B., additional, Munoz, Douglas P., additional, Mandzia, Jennifer, additional, Abrahao, Agessandro, additional, Binns, Malcolm A., additional, Black, Sandra E., additional, Borrie, Michael, additional, Dowlatshahi, Dar, additional, Freedman, Morris, additional, Fischer, Corinne E., additional, Finger, Elizabeth, additional, Frank, Andrew, additional, Grimes, David, additional, Hassan, Ayman, additional, Kumar, Sanjeev, additional, Lang, Anthony Edward, additional, Levine, Brian, additional, Marras, Connie, additional, Masellis, Mario, additional, Pollock, Bruce G., additional, Rajji, Tarek K., additional, Ramirez, Joel, additional, Sahlas, Demetrios J., additional, Saposnik, Gustavo, additional, Scott, Christopher J.M., additional, Seitz, Dallas P., additional, Strother, Stephen, additional, Sunderland, Kelly M., additional, Tan, Brian, additional, Tang-Wai, David, additional, Troyer, Angela K., additional, Turnbull, John, additional, Zinman, Lorne, additional, Swartz, Richard H., additional, Tartaglia, Carmela, additional, Breen, David P., additional, Kwan, Donna, additional, and Roberts, Angela, additional

Published
2020
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37. The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study

Author

McLaughlin, Paula M., primary, Sunderland, Kelly M., additional, Beaton, Derek, additional, Binns, Malcolm A., additional, Kwan, Donna, additional, Levine, Brian, additional, Orange, Joseph B., additional, Peltsch, Alicia J., additional, Roberts, Angela C., additional, Strother, Stephen C., additional, and Troyer, Angela K., additional

Published
2020
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41. The Quality Assurance and Quality Control Protocol for Neuropsychological Data Collection and Curation in the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study.

Author

McLaughlin, Paula M., Sunderland, Kelly M., Beaton, Derek, Binns, Malcolm A., Kwan, Donna, Levine, Brian, Orange, Joseph B., Peltsch, Alicia J., Roberts, Angela C., Strother, Stephen C., and Troyer, Angela K.

Subjects
DATA curation, DATA quality, NEUROPSYCHOLOGY, HEALTH outcome assessment, MEDICAL protocols, CONTENT mining, QUALITY assurance, NEURODEGENERATION, MEDICAL research
Abstract

As large research initiatives designed to generate big data on clinical cohorts become more common, there is an increasing need to establish standard quality assurance (QA; preventing errors) and quality control (QC; identifying and correcting errors) procedures for critical outcome measures. The present article describes the QA and QC approach developed and implemented for the neuropsychology data collected as part of the Ontario Neurodegenerative Disease Research Initiative study. We report on the efficacy of our approach and provide data quality metrics. Our findings demonstrate that even with a comprehensive QA protocol, the proportion of data errors still can be high. Additionally, we show that several widely used neuropsychological measures are particularly susceptible to error. These findings highlight the need for large research programs to put into place active, comprehensive, and separate QA and QC procedures before, during, and after protocol deployment. Detailed recommendations and considerations for future studies are provided. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Interprofessional team-based geriatric education and training: A review of interventions in Canada.

Author

Flores-Sandoval, Cecilia, Sibbald, Shannon, Ryan, Bridget L., and Orange, Joseph B.

Subjects
TEAMS in the workplace, ONLINE information services, CINAHL database, MEDICAL information storage & retrieval systems, GERIATRICS, SYSTEMATIC reviews, INTERDISCIPLINARY education, MEDLINE
Abstract

Given world-wide rises in the number of older adults, interprofessional education and training in geriatrics must be promoted across the learning spectrum, both for students and for health care professionals. This review examined interprofessional team-based education and training interventions in Canada focusing on the team component. A total of 10 studies (1997–2017) were eligible for analyzes. Studies offered health care providers opportunities to enhance their knowledge of geriatric competencies, as well as their ability to work in interprofessional geriatric teams. Although several interventions did not include team-based learning content explicitly, team-building opportunities, as well as assignments related to working on teams yielded positive impacts on learners. Results showed improved geriatric competencies as well as team functioning. Geriatric health care teams add significant value to the Canadian health care system. Consequently, opportunities to improve health care providers' geriatric knowledge and their ability to work in teams should be encouraged. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Healthcare teams and patient‐related terminology: a review of concepts and uses.

Author

Flores‐Sandoval, Cecilia, Sibbald, Shannon, Ryan, Bridget L., and Orange, Joseph B.

Subjects
HEALTH care teams, INTERPROFESSIONAL relations, LANGUAGE & languages, MEDICAL care, PATIENTS, TERMS & phrases, TEAMS in the workplace
Abstract

Background: Discussions concerning health care teams and patient‐related terminology remain an ongoing debate. Terms such as interdisciplinary, multidisciplinary and transdisciplinary, as well as interprofessional are ambiguously defined and frequently used, rightly or wrongly, interchangeably. Also, clarification on the terminology regarding patients is rarely explicitly addressed in the health care team's literature, potentially resulting in confusion among health professional students, novice researchers, and practitioners. Methods: A structured literature review was conducted. Electronic searches were performed from August 2018 to September 2019 on the following databases: CINHAL, Scopus, Science Direct, PubMed, Nursing and Allied Health and JSTOR. The following terms were used: 'terminology', 'team(s)', 'nursing', 'health', 'medical', 'education', 'interprofessional', 'interdisciplinary', 'multidisciplinary', 'transdisciplinary', 'collaboration', 'patient', 'client', 'customer', 'user' and 'person'. Results: Small but significant nuances in the use of language and its implications for patient care can be made visible for health professional education and clinical practice. Healthcare is necessarily interdisciplinary and therefore we are obligated, and privileged, to think more critically about the use of terminology to ensure we are supporting high‐quality evidence and knowledge application. Conclusion: To avoid confusion and lack of consistency in the peer‐review literature, authors should be encouraged to offer brief definitions and the rationale for the use of a particular term or group of term. In addition, a deeper understanding of the values that each patient‐related term represents for particular disciplines or health care professions is essential to achieve a more comprehensive conceptual rigour. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Non-Alzheimer’s Dementia

Author

Roberts, Angela, Savundranayagam, Marie Y, and Orange, Joseph B

Subjects
Medicine and Health Sciences, Social and Behavioral Sciences
Published
2017

47. Combined impairments in vision, hearing and cognition are associated with greater levels of functional and communication difficulties than cognitive impairment alone: Analysis of interRAI data for home care and long-term care recipients in Ontario

Author

Guthrie, Dawn M., primary, Davidson, Jacob G. S., additional, Williams, Nicole, additional, Campos, Jennifer, additional, Hunter, Kathleen, additional, Mick, Paul, additional, Orange, Joseph B., additional, Pichora-Fuller, M. Kathleen, additional, Phillips, Natalie A., additional, Savundranayagam, Marie Y., additional, and Wittich, Walter, additional

Published
2018
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48. Matched and mismatched appraisals of the effectiveness of communication strategies by family caregivers

Author

Savundranayagam, Marie Y and Orange, Joseph B

Subjects
Medicine and Health Sciences, Social and Behavioral Sciences
Abstract

Background: Communication problems stemming from Alzheimer’s disease (AD) often result in misunderstandings that can be linked with problem behaviours and increased caregiver stress. Moreover, these communication breakdowns also can result either from caregivers’ use of ineffective communication strategies, which paradoxically are perceived as helpful, or can occur as a result of not using effective communication strategies that are perceived as unhelpful.Aims: The two primary aims were to determine the effectiveness of strategies used to resolve communicationbreakdowns and to examine whether caregivers’ ratings of strategy effectiveness were consistent with evidence from video-recorded conversations and with effective communication strategies documented in the literature.Methods&Procedures: Twenty-eight mealtime conversations were recorded using a sample of 15 dyads consisting of individuals with early, middle and late clinical-stage AD and their family caregivers. Conversations were analysed using the trouble-source repair paradigm to identify the communication strategies used by caregivers to resolve breakdowns. Family caregivers also rated the helpfulness of communication strategies used to resolve breakdowns.Analyses were conducted to assess the overlap or match between the use and appraisals of the helpfulness ofcommunication strategies.Outcomes & Results: Matched and mismatched appraisals of communication strategies varied across stages of AD. Matched appraisals by caregivers of persons with early-stage AD were observed for 68% of 22 communication strategies, whereas caregivers of persons with middle- and late-stage AD had matched appraisals for 45% and 55% of the strategies, respectively.Moreover, caregivers of persons with early-stage AD had matched appraisals over and above making matched appraisals by chance alone, compared with caregivers of persons in middle- and late-stage AD.Conclusions & Implications:Mismatches illustrate the need for communication education and training, particularlyto establish empirically derived evidence-based communication strategies over the clinical course of AD.

Published
2014

49. White Matter Correlates of Spoken Discourse in Cerebrovascular Disease.

Author

Broberg, Dana N, Haddad, Seyyed Mohammad Hassan, Aveni, Katharine, Havens, Alexander, Orange, Joseph B, McLaughlin, Paula, Binns, Malcolm, Roberts, Angela C, and Bartha, Robert

Abstract

Background: Spoken discourse (language beyond single words or sentences) performance can be used to detect cognitive impairment in cerebrovascular disease (CVD) [Roberts A, et al. (2021). Top Lang Disord 41(1):73‐98]. However, the neurological basis for altered spoken discourse in CVD is poorly defined. This study examined the association between spoken discourse and indicators of white matter microstructural integrity provided by diffusion tensor imaging (DTI) to better define the link between CVD‐related neurodegeneration and altered spoken discourse. Method: Spoken discourse and 3T DTI data (30‐32 directions, b=1000) were obtained from the CVD cohort of the Ontario Neurodegenerative Disease Research Initiative (n=133). Spoken discourse analyses were completed previously [Roberts, 2021]. A DTI analysis pipeline [Hassan SMH, et al. (2019) PLoS One 14(12):e0226715] was used to generate brain maps of fractional anisotropy (FA) and mean diffusivity (MD) and calculate mean FA and MD values for the inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus – parietal (SLFp) and temporal (SLFt) endings, and uncinate fasciculi (UNC) in each hemisphere. Canonical correlation analyses examined associations between DTI metrics and 10 spoken discourse measures separately for FA in left hemisphere, MD in left hemisphere, FA in right hemisphere, MD in right hemisphere. Result: Canonical correlations were significant in the left hemisphere (FA: r=0.47, p<0.05; MD: r=0.51, p<0.01) but not the right (FA: r=0.34, p=0.90; MD: r=0.40, p=0.15)(Figure 1). Among the white matter tracts, the strongest canonical loadings were seen for the SLFp (FA: 0.81; MD: ‐0.59) and SLFt (FA: 0.71; MD: ‐0.40) compared to the ILF (FA: 0.44; MD: 0.03) and UNC (FA: ‐0.34; MD: 0.10). Higher FA in the SLFp and SLFt was associated with better performance on measures of fluency and information content. Lower MD in these tracts was associated with better performance on measures of fluency, information content, and syntax. Conclusion: Spoken discourse performance was associated with white matter microstructural integrity in the left hemisphere of the brain. Of the white matter tracts investigated in this study, impaired spoken discourse performance in CVD was most strongly linked to altered tissue microstructure in the parietal and temporal endings of the superior longitudinal fasciculus. [ABSTRACT FROM AUTHOR]

Published
2022
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