1. Oral transmission of L-type bovine spongiform encephalopathy agent among cattle
- Author
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Kentaro Masujin, Kohtaro Miyazawa, Morikazu Imamura, Yuichi Matsuura, Hiroyuki Okada, Yuichi Murayama, Yoshifumi Iwamaru, and Takashi Yokoyama
- Subjects
0301 basic medicine ,Microbiology (medical) ,Epidemiology ,Prions ,Bovine spongiform encephalopathy ,animal diseases ,030106 microbiology ,lcsh:Medicine ,atypical bovine spongiform encephalopathy ,lcsh:Infectious and parasitic diseases ,prion ,03 medical and health sciences ,Bovine spongiform encephalopathy agent ,oral transmission ,medicine ,L-BSE ,Animals ,lcsh:RC109-216 ,L-type ,Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle ,Transmission (medicine) ,business.industry ,lcsh:R ,Dispatch ,Brain ,medicine.disease ,Virology ,Immunohistochemistry ,Transmissibility (vibration) ,nervous system diseases ,zoonoses ,Atypical bovine spongiform encephalopathy ,prions and related diseases ,Encephalopathy, Bovine Spongiform ,stomatognathic diseases ,030104 developmental biology ,Infectious Diseases ,cattle ,Female ,business - Abstract
To determine oral transmissibility of the L-type bovine spongiform encephalopathy (BSE) prion, we orally inoculated 16 calves with brain homogenates of the agent. Only 1 animal, given a high dose, showed signs and died at 88 months. These results suggest low risk for oral transmission of the L-BSE agent among cattle.
- Published
- 2017
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