104 results on '"Opris, Daniela"'
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2. Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study
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AELION, Jacob, AMARELO-RAMOS, Juan, BALSA, Alejandro, BERGHEA, Florian, BRZEZICKI, Jan, BURNETTE, Michael, FRETZIN, Scott, GARCÍA-CARAZO, Sara, GLADSTEIN, Geoffrey, GOMEZ-REINO, Juan, GOODERHAM, Melinda, GONZÁLEZ-FERNÁNDEZ, Carlos, GOTTLIEB, Alice, GRATACOS, Jordi, HAALAND, Derek, KAMALOVA, Rima, LESZCZYNSKI, Piotr, MARTIN-MOLA, Emilio, MASLYANSKY, Alexey, NAVARRO, Federico, OPRIS, Daniela, PAPP, Kim, PERLAMUTROV, Yuriy, PHILIPP, Sandra, RACEWICZ, Artur, REBROV, Andrey, RELL-BAKALARSKA, Maria, ROSMARIN, David, RUBBERT-ROTH, Andrea, SHERGY, William, SHIRINSKY, Ivan, SONIN, Dmitry, STANISLAV, Marina, SUKHAREV, Alexey, TEMNIKOV, Vadim, VINOGRADOVA, Irina, WAYTZ, Paul, YAKUSHEVICH, Vladimir, Deodhar, Atul, Gottlieb, Alice B, Boehncke, Wolf-Henning, Dong, Bin, Wang, Yuhua, Zhuang, Yanli, Barchuk, William, Xu, Xie L, and Hsia, Elizabeth C
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- 2018
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3. Three-month tapering and discontinuation of long- term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial
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Almayali, Abdullah Ali Hadi, primary, Boers, Maarten, additional, Hartman, Linda, additional, Opris, Daniela, additional, Bos, Reinhard, additional, Kok, Marc R, additional, Da Silva, Jose AP, additional, Griep, Ed, additional, Klaasen, Ruth, additional, Allaart, Cornelia F, additional, Baudoin, Paul, additional, Raterman, Hennie G, additional, Szekanecz, Zoltan, additional, Buttgereit, Frank, additional, Masaryk, Pavol, additional, Lems, Willem, additional, Smulders, Yvo, additional, Cutolo, Maurizio, additional, and ter Wee, Marieke M, additional
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- 2023
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4. Three-month tapering and discontinuation of long-term, low-dose glucocorticoids in senior patients with rheumatoid arthritis is feasible and safe: placebo-controlled double blind tapering after the GLORIA trial.
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Hadi Almayali, Abdullah Ali, Boers, Maarten, Hartman, Linda, Opris, Daniela, Bos, Reinhard, Kok, Marc R., Ap Da Silva, Jose, Griep, Ed, Klaasen, Ruth, Allaart, Cornelia F., Baudoin, Paul, Raterman, Hennie G., Szekanecz, Zoltan, Buttgereit, Frank, Masaryk, Pavol, Lems, Willem, Smulders, Yvo, Cutolo, Maurizio, and Ter Wee, Marieke M.
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- 2023
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5. A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study
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Airò, Paolo, Alegre-Sancho, Juan Jose, Allanore, Yannick, Ananieva, Lidia P., Ancuta, Codrina, Andrade, Luis Eduardo, Aringer, Martin, Becvar, Radim, Bojinca, Mihai, Butrimiene, Irena, Cantatore, Francesco Paolo, Caporali, Roberto, Caramaschi, Paola, Carreira, Patricia E., Chirieac, Rodica, Corrado, Ada, Cosentino, Vanesa, Cuomo, Giovanna, Czirjak, Laszlo, Da Silva, José Antonio Pereira, la Peña Lefebvre, Paloma García de, De Keyser, Filip, de Souza Müller, Carolina, Damgaard, Kirsten, Damjanov, Nemanja, Denisov, Lev N., Distler, Oliver, Doube, Alan, Dumitrascu, Alina, Engelhart, Merete, Exposito, Marta Valero, Eyerich, Kilian, Farge-Bancel, Dominique, Azevedo, Valderílio Feijó, Foti, Rosario, Frerix, Marc, Gabrielli, Armando, Garen, Torhild, Gottschalk, Paola, Groseanu, Laura, Guiducci, Serena, Günther, Claudia, Hachulla, Eric, Hein, Rüdiger, Heitmann, Stefan, Henes, Jörg, Hesselstrand, Roger, Highton, John, Iannone, Florenzo, Ionescu, Ruxandra Maria, Kayser, Cristiane, Karpec, Diana, Kerzberg, Eduardo, Kotulska, Anna, Kopec-Medrek, Magdalena, Kucharz, Eugene, Krummel-Lorenz, Brigitte, Lauffer, Felix, Launay, David, Li, Mengtao, Litinsky, Ira, Loyo, Esthela, Cerinic, Marco Matucci, Meroni, Pierluigi, Midtvedt, Øyvind, Mihai, Carmen Marina, Montecucco, Carlomaurizio, Montoya, Fabiana, Morgiel, Ewa, Mouthon, Luc, Müller-Ladner, Ulf, Nielsen, Henrik, Opris, Daniela, Ortiz-Santamaria, Vera, Otsa, Kati, Pileckyte, Margarita, Pisarri, Simonetta, Popescu, Monica, Pozzi, Maria Rosa, Puppo, Francesco, Radominski, Sebastião Cezar, Riccieri, Valeria, Rosato, Edoardo, Rozman, Blaz, Rubio, Silvia Rodriguez, Rugiene, Rita, Saar, Petra, Salvador, Maria João, Seidel, Matthias, Sokolik, Renata, Solanki, Kamal, Stamenkovic, Bojana, Stankovic, Aleksandra, Stebbings, Simon, Strauss, Gitte, Sulli, Alberto, Szamosi, Szilvia, Szechinski, Jacek, Szmyrka-Kaczmarek, Magdalena, Szücs, Gabriella, Tanaseanu, Cristina-Mihaela, Tiglea, Isabela, Tyndall, Alan, Ughi, Nicola, Uprus, Maria, Vacca, Alessandra, Varju, Cecilia, Venalis, Algirdas, Venalis, Paulius, Walker, Ulrich A., Widuchowska, Malgorzata, Wiland, Piotr, Wuttge, Dirk M., Zeni, Silvana, Zenone, Thierry, Ingegnoli, Francesca, Boracchi, Patrizia, Gualtierotti, Roberta, Smith, Vanessa, Cutolo, Maurizio, and Foeldvari, Ivan
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- 2015
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6. BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets
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Ancuta, Codrina, primary, Pomirleanu, Cristina, additional, Mihailov, Claudia, additional, Ancuta, Eugen, additional, and Opris, Daniela, additional
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- 2017
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7. Prediction of improvement in skin fibrosis in diffuse cutaneous systemic sclerosis: a EUSTAR analysis
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Dobrota, Rucsandra, Maurer, Britta, Graf, Nicole, Jordan, Suzana, Mihai, Carina, Kowal-Bielecka, Otylia, Allanore, Yannick, Distler, Oliver, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriela, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, André, Vlachoyiannopoulos, P., Montecucco, C., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Czirják, László, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Airò, Paolo, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M, Andréasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, F., Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Mauriziano, Ospedale, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jörg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J., Silva, José Antonio Pereira Da, Stamenkovic, Bojana, Stankovic, Aleksandra, Banja, Niska, Tikly, Mohammed, Ananieva, Lidia P., Denisov, Lev N., Müller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Clinica, U.O. Immunologia, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Walter A. Sifuentes, Midtvedt, Øyvind, Reiseter, Silje, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco P., Corrado, Ada, Pozzi, Maria R., Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Krummel-Lorenz, Brigitte, Aringer, Martin, Günther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C., de Souza Müller, Carolina, Azevedo, Valderílio F., Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, O’Donnell, John, Solanki, Kamal, Veale, Douglas, OʼRourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Amoroso, Antonio, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Villiger, Peter, Adler, Sabine, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Spertini, François, Ribi, Camillo, Buss, Guillaume, Pasquali, Jean Louis, Martin, Thierry, and Gorse, Audrey
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- 2016
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8. Mapping and predicting mortality from systemic sclerosis
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Elhai, Muriel, Meune, Christophe, Boubaya, Marouane, Avouac, Jérôme, Hachulla, Eric, Balbir-Gurman, Alexandra, Riemekasten, Gabriela, Airò, Paolo, Joven, Beatriz, Vettori, Serena, Cozzi, Franco, Ullman, Susanne, Czirják, László, Tikly, Mohammed, Müller-Ladner, Ulf, Caramaschi, Paola, Distler, Oliver, Iannone, Florenzo, Ananieva, Lidia P, Hesselstrand, Roger, Becvar, Radim, Gabrielli, Armando, Damjanov, Nemanja, Salvador, Maria J, Riccieri, Valeria, Mihai, Carina, Szücs, Gabriella, Walker, Ulrich A, Hunzelmann, Nicolas, Martinovic, Duska, Smith, Vanessa, Müller, Carolina de Souza, Montecucco, Carlo Maurizio, Opris, Daniela, Ingegnoli, Francesca, Vlachoyiannopoulos, Panayiotis G, Stamenkovic, Bojana, Rosato, Edoardo, Heitmann, Stefan, Distler, Jörg H W, Zenone, Thierry, Seidel, Matthias, Vacca, Alessandra, Langhe, Ellen De, Novak, Srdan, Cutolo, Maurizio, Mouthon, Luc, Henes, Jörg, Chizzolini, Carlo, Mühlen, Carlos Alberto von, Solanki, Kamal, Rednic, Simona, Stamp, Lisa, Anic, Branimir, Santamaria, Vera Ortiz, Santis, Maria De, Yavuz, Sule, Sifuentes-Giraldo, Walter Alberto, Chatelus, Emmanuel, Stork, Jiri, Laar, Jacob van, Loyo, Esthela, García de la Peña Lefebvre, Paloma, Eyerich, Kilian, Cosentino, Vanesa, Alegre-Sancho, Juan Jose, Kowal-Bielecka, Otylia, Rey, Grégoire, Matucci-Cerinic, Marco, and Allanore, Yannick
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- 2017
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9. Assessment of skin involvement in systemic sclerosis
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Kumánovics, Gábor, Péntek, Márta, Bae, Sangmee, Opris, Daniela, Khanna, Dinesh, Furst, Daniel E., and Czirják, László
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- 2017
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10. “To Be or Not To Be,” Ten Years After: Evidence for Mixed Connective Tissue Disease as a Distinct Entity
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Cappelli, Susanna, Bellando Randone, Silvia, Martinović, Dušanka, Tamas, Maria-Magdalena, Pasalić, Katarina, Allanore, Yannick, Mosca, Marta, Talarico, Rosaria, Opris, Daniela, Kiss, Csaba G., Tausche, Anne-Kathrin, Cardarelli, Silvia, Riccieri, Valeria, Koneva, Olga, Cuomo, Giovanna, Becker, Mike Oliver, Sulli, Alberto, Guiducci, Serena, Radić, Mislav, Bombardieri, Stefano, Aringer, Martin, Cozzi, Franco, Valesini, Guido, Ananyeva, Lidia, Valentini, Gabriele, Riemekasten, Gabriela, Cutolo, Maurizio, Ionescu, Ruxandra, Czirják, László, Damjanov, Nemanja, Rednic, Simona, and Matucci Cerinic, Marco
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- 2012
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11. A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study
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Elhai, Muriel, Avouac, Jérôme, Walker, Ulrich A, Matucci-Cerinic, Marco, Riemekasten, Gabriela, Airò, Paolo, Hachulla, Eric, Valentini, Gabriele, Carreira, Patricia E, Cozzi, Franco, Balbir Gurman, Alexandra, Braun-Moscovici, Yolanda, Damjanov, Nemanja, Ananieva, Lidia P, Scorza, Raffaella, Jimenez, Sergio, Busquets, Joanna, Li, Mengtao, Müller-Ladner, Ulf, Kahan, André, Distler, Oliver, Allanore, Yannick, Guiducci, Serena, Tyndall, Alan, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Cuomo, Giovanna, Vettori, Serena, Rednic, Simona, Nicoara, Ileana, Vlachoyiannopoulos, P., Montecucco, C., Caporali, Roberto, Novak, Srdan, Czirják, László, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Govoni, M., Monaco, Andrea Lo, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Denton, Christopher, Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N., Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Zea Mendoza, Antonio, de la Puente Buijdos, Carlos, Sifuentes Giraldo, Walter A., Midtvedt, Øyvind, Garen, Torhild, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M., Mihai, Carmen M., Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Smith, Vanessa, Cantatore, Francesco P., Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R., Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C., Müller, Carolina de Souza, Azevedo, Valderílio F., Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Stebbings, Simon, Highton, John, Stamp, Lisa, Chapman, Peter, Baron, Murray, OʼDonnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, OʼRourke, Marie, Loyo, Esthela, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E., Kafaja, Suzanne, Lefebvre, Paloma García de la Peña, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Kerzberg, Eduardo, Montoya, Fabiana, and Cosentino, Vanesa
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- 2016
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12. Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study
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Avouac, Jérôme, Walker, Ulrich A, Hachulla, Eric, Riemekasten, Gabriela, Cuomo, Giovanna, Carreira, Patricia E, Caramaschi, Paola, Ananieva, Lidia P, Matucci-Cerinic, Marco, Czirjak, Laszlo, Denton, Christopher, Ladner, Ulf Müller, Allanore, Yannick, Guiducci, Serena, Tyndall, Alan, Lapadula, Giovanni, Iannone, Florenzo, Distler, Oliver, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlomaurizio, Caporali, Roberto, Novak, Srdan, Chizzolini, Carlo, Kucharz, Eugene J., Kotulska, Anna, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge-Bancel, Dominique, Hadj-Khelifa, Sondess, Airò, Paolo, Hesselstrand, Roger, Scheja, Agneta, Martinovic, Duska, Gurman, Alexandra Balbir, Braun-Moscovici, Yolanda, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Morovic-Vergles, Jadranka, Black, Carol, Damjanov, Nemanja, Kötter, Ina, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Silva, José Antonio Pereira Da, Salvador, Maria João, Stamenkovi, Bojana, Stankovic, Aleksandra, Marasini, Bianca, Belloli, Laura, Tikly, Mohammed, Denisov, Lev N., Scorza, Raffaella, Engelhart, Merete, Strauss, Gitte, Szücs, Gabriella, Szamosi, Szilvia, de la Puente, Carlos, de la Pena Lefebvre, Paloma García, Midtvedt, Øyvind, Garen, Torhild, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Wigley, Fredrick M., Stoica, Viktor, Mihai, Carmen Marina, Distler, Jörg, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Rüdiger, Szechinski, Jacek, Wiland, Piotr, Krummel-Lorenz, Brigitte, Aringer, Martin, Westhovens, Rene, De Langhe, Ellen, Anic, Branimir, Baresi, Marko, Üprus, Maria, Otsa, Kati, Yavuz, Sule, Radominski, Sebastião Cezar, de Souza Müller, Carolina, Jimenez, Sergio, Busquets, Joanna, Popa, Sergei, Agachi, Svetlana, Zenone, Thierry, Mathieu, Alessandro, Vacca, Alessandra, Stamp, Lisa, Chapman, Peter, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Foti, Rosario, and Rubio, Silvia Rodriguez
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- 2016
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13. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database
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Maurer, Britta, Graf, Nicole, Michel, Beat A, Müller-Ladner, Ulf, Czirják, László, Denton, Christopher P, Tyndall, Alan, Metzig, Carola, Lanius, Vivian, Khanna, Dinesh, Distler, Oliver, Tarner, Ingo H, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Lapadula, Giovanni, Iannone, Florenzo, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Vettori, Serena, Riemekasten, Gabriele, Rednic, Simona, Nicoara, Ileana, Kahan, André, Allanore, Yannick, Vlachoyiannopoulos, P, Montecucco, C, Caporali, Roberto, Carreira, Patricia E, Novak, Srdan, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J, Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Hij, Adrian, Airò, Paolo, Hesselstrand, Roger, Scheja, Agneta, Wollheim, Frank, Martinovic, Duska, Gurman, Alexandra Balbir, Braun-Moscovici, Yolanda, Govoni, M, Monaco, Andrea Lo, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Oleszowsky, Mara, Burkhardt, Harald, Himsel, Andrea, Salvador, Maria J, Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Starovoytova, Maya N, Ananieva, Lidia P, Scorza, Raffaella, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szücs, Gabriella, Mendoza, Antonio Zea, Buijdos, Carlos de la Puente, Sifuentes Giraldo, Walter A., Midtvedt, Øyvind, Garen, Torhild, Hachulla, Eric, Launay, David, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Mihai, Carmen M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Gorga, Marilena, Dobrota, Rucsandra, Bojinca, Mihai, Schett, Georg, Distler, Jörg HW, Meroni, Pierluigi, Zeni, Silvana, Mouthon, Luc, Keyser, Filip De, Cantatore, Francesco P, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria R, Eyerich, Kilian, Hein, Rüdiger, Knott, Elisabeth, Szechinski, Jacek, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Günther, Claudia, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Radominski, Sebastião C, Müller, Carolina de Souza, Azevedo, Valderílio F, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Zenone, Thierry, Highton, John, Stamp, Lisa, Chapman, Peter, OʼDonnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O’Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Pisarri, Simonetta, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Chirieac, Rodica, Ancuta, Codrina, E Furst, Daniel, Kafaja, Suzanne, Lefebvre, Paloma García de la Peña, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Hélène, Litinsky, Ira, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Kerzberg, Eduardo, Montoya, Fabiana, and Cosentino, Vanesa
- Published
- 2015
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14. Phenotypes determined by cluster analysis and their survival in the prospective European Scleroderma Trials and Research cohort of patients with systemic sclerosis
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Sobanski, Vincent, Giovannelli, Jonathan, Allanore, Yannick, Riemekasten, Gabriela, Airo, Paolo, Vettori, Serena, Cozzi, Franco, Distler, Oliver, Matucci-Cerinic, Marco, Denton, Christopher, Launay, David, Hachulla, Eric, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Kyburz, Diego, Lapadula, Giovanni, Iannone, Florenzo, Maurer, Britta, Jordan, Suzana, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis, Montecucco, Carlo, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E, Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J, Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M, Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, Francesco, Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Nuova, Arcispedale Santa Maria, Salvador, Maria Joao, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Marasini, Bianca, Tikly, Mohammed, Ananieva, Lidia P, Denisov, Lev N, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriella, Szamosi, Szilvia, Zea Mendoza, Antonio, de la Puente, Carlos, Sifuentes Giraldo, Walter Alberto, Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Mihai, Carina, Milicescu, Mihaela, Sunderkoetter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Distler, Joerg HW, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, von Muehlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D, Yoshinari, Natalino H, Marangoni, Roberta G, Martin, Patricia, Fuocco, Luiza, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Eduardo, Andrade Luis C, Fathi, Nihal, Hassanien, Manal, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A, Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Kahl, Sarah, Hsu, Vivien M, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Pasquali, Jean Louis, Martin, Thierry, Gorse, Audrey, Guffroy, Aurelien, Poindron, Vincent, EUSTAR Collaborators, Guiducci, S., Walker, U., Kyburz, D., Lapadula, G., Iannone, F., Maurer, B., Jordan, S., Becvar, R., Sierakowsky, S., Kowal Bielecka, O., Cutolo, M., Sulli, A., Valentini, G., Cuomo, G., Siegert, E., Rednic, S., Nicoara, I., Kahan, A., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Stork, J., Inanc, M., Carreira, P.E., Novak, S., Czirják, L., Varju, C., Chizzolini, C., Kucharz, E.J., Kotulska, A., Kopec-Medrek, M., Widuchowska, M., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Wu, C., Marjanovic, Z., Faivre, H., Hij, D., Dhamadi, R., Airò, P., Hesselstrand, R., Wollheim, F., Wuttge, D.M., Andréasson, K., Martinovic, D., Balbir-Gurman, A., Braun-Moscovici, Y., Trotta, F., Lo Monaco, A., Hunzelmann, N., Pellerito, R., Mauriziano, O., Maria Bambara, L., Caramaschi, P., Morovic-Vergles, J., Black, C., Damjanov, N., Henes, J., Ortiz Santamaria, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Burkhardt, H., Himsel, A., Bajocchi, G., Maria Nuova, A.S., João Salvador, M., Pereira Da Silva, J.A., Stamenkovic, B., Stankovic, A., Francesco Selmi, C., De Santis, M., Marasini, B., Tikly, M., Ananieva, L.P., Denisov, L.N., Müller-Ladner, U., Frerix, M., Tarner, I., Scorza, R., Puppo, F., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szücs, G., Szamosi, S., Zea Mendoza, A., de la Puente, C., Sifuentes Giraldo, W.A., Midtvedt, Ø., Reiseter, S., Garen, T., Valesini, G., Riccieri, V., Maria Ionescu, R., Opris, D., Groseanu, L., Wigley, F.M., Sfrent Cornateanu, R., Ionitescu, R., Maria Gherghe, A., Soare, A., Gorga, M., Bojinca, M., Mihai, C., Milicescu, M., Sunderkötter, C., Kuhn, A., Sandorfi, N., Schett, G., Distler, J.H., Beyer, C., Meroni, P., Ingegnoli, F., Mouthon, L., De Keyser, F., Smith, V., Paolo Cantatore, F., Corrado, A., Ullman, S., Iversen, L., Alberto von Mühlen, C., Marilu Bohn, J., Scussel Lonzetti, L., Rosa Pozzi, M., Eyerich, K., Hein, R., Knott, E., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Madej, M., Houssiau, F.A., Jose Alegre-Sancho, J., Krummel-Lorenz, B., Saar, P., Aringer, M., Günther, C., Westhovens, R., de Langhe, E., Lenaerts, J., Anic, B., Baresic, M., Mayer, M., Üprus, M., Otsa, K., Yavuz, S., Granel, B., Cezar Radominski, S., de Souza Müller, C., Azevedo, V.F., Jimenez, S., Busquets, J., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Popa, S., Zenone, T., Pileckyte, M., Stebbings, S., Highton, J., Mathieu, A., Vacca, A., Sampaio-Barros, P.D., Yoshinari, N.H., Marangoni, R.G., Martin, P., Fuocco, L., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Abdel Atty Mohamed, W.A., Rosato, E., Amoroso, A., Gigante, A., Oksel, F., Yargucu, F., Tanaseanu, C.M., Popescu, M., Dumitrascu, A., Tiglea, I., Foti, R., Chirieac, R., Ancuta, C., Furst, D.E., Villiger, P., Adler, S., van Laar, J., Kayser, C., Eduardo C, A.L., Fathi, N., Hassanien, M., de la Peña Lefebvre, P.G., Rodriguez Rubio, S., Valero Exposito, M., Sibilia, J., Chatelus, E., Gottenberg, J.E., Chifflot, H., Litinsky, I., Emery, P., Buch, M., Del Galdo, F., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Ann Saketkoo, L., Lasky, J.A., Kerzberg, E., Montoya, F., Cosentino, V., Limonta, M., Luca Brucato, A., Lupi, E., Rosner, I., Rozenbaum, M., Slobodin, G., Boulman, N., Rimar, D., Couto, M., Spertini, F., Ribi, C., Buss, G., Kahl, S., Hsu, V.M., Chen, F., McCloskey, D., Malveaux, H., Louis Pasquali, J., Martin, T., Gorse, A., Guffroy, A., Poindron, V., and Chizzolini, Carlo
- Subjects
0301 basic medicine ,Male ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Databases, Factual ,systemic sclerosis ,SUBSETS ,Disease ,Severity of Illness Index ,Scleroderma ,DISEASE ,0302 clinical medicine ,Medicine and Health Sciences ,Immunology and Allergy ,Cluster Analysis ,CRITERIA ,Prospective Studies ,Prospective cohort study ,skin and connective tissue diseases ,integumentary system ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,Adult ,Aged ,Autoantibodies/blood ,Europe/epidemiology ,Female ,Humans ,Middle Aged ,Phenotype ,Prognosis ,Scleroderma, Diffuse/blood ,Scleroderma, Diffuse/epidemiology ,Scleroderma, Diffuse/pathology ,Scleroderma, Limited/blood ,Scleroderma, Limited/epidemiology ,Scleroderma, Limited/pathology ,Scleroderma, Systemic/blood ,Scleroderma, Systemic/epidemiology ,Scleroderma, Systemic/pathology ,Connective tissue disease ,ddc ,Europe ,MANIFESTATIONS ,Cohort ,Life Sciences & Biomedicine ,medicine.medical_specialty ,Immunology ,PROFILE ,CLASSIFICATION ,03 medical and health sciences ,Rheumatology ,Scleroderma, Limited ,Internal medicine ,Severity of illness ,medicine ,Autoantibodies ,030203 arthritis & rheumatology ,Science & Technology ,Scleroderma, Systemic ,business.industry ,Autoantibody ,Systemic sclerosis (SSc) ,medicine.disease ,030104 developmental biology ,Scleroderma, Diffuse ,business - Abstract
OBJECTIVE: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. METHODS: A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. RESULTS: Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. CONCLUSION: Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis. ispartof: ARTHRITIS & RHEUMATOLOGY vol:71 issue:9 pages:1553-1570 ispartof: location:United States status: published
- Published
- 2019
15. Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
- Author
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Elhai, Muriel, Boubaya, Marouane, Distler, Oliver, Smith, Vanessa, Matucci-Cerinic, Marco, Alegre Sancho, Juan Jose, Truchetet, Marie-Elise, Braun-Moscovici, Yolanda, Iannone, Florenzo, Novikov, Pavel I., Lescoat, Alain, Siegert, Elise, Castellvi, Ivan, Airo, Paolo, Vettori, Serena, De Langhe, Ellen, Hachulla, Eric, Erler, Anne, Ananieva, Lidia, Krusche, Martin, Lopez-Longo, F. J., Distler, Joerg H. W., Hunzelmann, Nicolas, Hoffmann-Vold, Anna-Maria, Riccieri, Valeria, Hsu, Vivien M., Pozzi, Maria R., Ancuta, Codrina, Rosato, Edoardo, Mihai, Carina, Kuwana, Masataka, Saketkoo, Lesley Ann, Chizzolini, Carlo, Hesselstrand, Roger, Ullman, Susanne, Yavuz, Sule, Rednic, Simona, Caimmi, Cristian, Bloch-Queyrat, Coralie, Allanore, Yannick, Guiducci, Serena, Walker, Ulrich A., Kyburz, Diego, Lapadula, Giovanni, Maurer, Britta, Jordan, Suzana, Dobrota, Rucsandra, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Sulli, Alberto, Cutolo, Maurizio, Cuomo, Giovanna, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlo Maurizio, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Scheja, Agneta, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Trotta, F., Lo Monaco, Andrea, Pellerito, Raffaele, Mauriziano, Ospedale, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jorg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Da Silva, Jose Antonio Pereira, Salvador, Maria Joao, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Tikly, Mohammed, Denisov, Lev N., Herrick, Ariane, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriela, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Sifuentes W. A., Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Launay, David, Valesini, Guido, Ionescu, Ruxandra Maria, Groseanu, Laura, Opris, Daniela, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Milicescu, Mihaela, Sunderkotter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Melsens, Karin, Cantatore, Francesco P., Corrado, Ada, Iversen, Line, von Muhlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Eyerich, Kilian, Hein, Rudiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Gunther, Claudia, Westhovens, Rene, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Granel, Brigitte, Muller, Carolina de Souza, Radominski, Sebastiao C., Azevedo, Valderilio F., Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stebbings, Simon, Highton, John, Chapman, Peter, O'Donnell, John, Stamp, Lisa, Doube, Alan, Solanki, Kamal, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Furst, Daniel, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, Hassanien, Manal, Lefebvre, Paloma Garcia de la Pena, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Sibilia, Jean, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Lasky, Joseph A., Cosentino, Vanesa, Kerzberg, Eduardo, Montoya, Fabiana, Bianchi, Washington, Carneiro, Sueli, Maretti, Giselle Baptista, Bianchi, Dante Valdetaro, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Kahl, Sarah, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chotchaeva, Fatima, Mukhin, Nikolay A., Moiseev, Sergey, Elhai, Muriel, Boubaya, Marouane, Distler, Oliver, Smith, Vanessa, Matucci-Cerinic, Marco, Alegre Sancho, Juan Jose, Truchetet, Marie-Elise, Braun-Moscovici, Yolanda, Iannone, Florenzo, Novikov, Pavel I., Lescoat, Alain, Siegert, Elise, Castellvi, Ivan, Airo, Paolo, Vettori, Serena, De Langhe, Ellen, Hachulla, Eric, Erler, Anne, Ananieva, Lidia, Krusche, Martin, Lopez-Longo, F. J., Distler, Joerg H. W., Hunzelmann, Nicolas, Hoffmann-Vold, Anna-Maria, Riccieri, Valeria, Hsu, Vivien M., Pozzi, Maria R., Ancuta, Codrina, Rosato, Edoardo, Mihai, Carina, Kuwana, Masataka, Saketkoo, Lesley Ann, Chizzolini, Carlo, Hesselstrand, Roger, Ullman, Susanne, Yavuz, Sule, Rednic, Simona, Caimmi, Cristian, Bloch-Queyrat, Coralie, Allanore, Yannick, Guiducci, Serena, Walker, Ulrich A., Kyburz, Diego, Lapadula, Giovanni, Maurer, Britta, Jordan, Suzana, Dobrota, Rucsandra, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Sulli, Alberto, Cutolo, Maurizio, Cuomo, Giovanna, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlo Maurizio, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Scheja, Agneta, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Trotta, F., Lo Monaco, Andrea, Pellerito, Raffaele, Mauriziano, Ospedale, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jorg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Da Silva, Jose Antonio Pereira, Salvador, Maria Joao, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Tikly, Mohammed, Denisov, Lev N., Herrick, Ariane, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriela, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Sifuentes W. A., Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Launay, David, Valesini, Guido, Ionescu, Ruxandra Maria, Groseanu, Laura, Opris, Daniela, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Milicescu, Mihaela, Sunderkotter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Melsens, Karin, Cantatore, Francesco P., Corrado, Ada, Iversen, Line, von Muhlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Eyerich, Kilian, Hein, Rudiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Gunther, Claudia, Westhovens, Rene, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Granel, Brigitte, Muller, Carolina de Souza, Radominski, Sebastiao C., Azevedo, Valderilio F., Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stebbings, Simon, Highton, John, Chapman, Peter, O'Donnell, John, Stamp, Lisa, Doube, Alan, Solanki, Kamal, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Furst, Daniel, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, Hassanien, Manal, Lefebvre, Paloma Garcia de la Pena, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Sibilia, Jean, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Lasky, Joseph A., Cosentino, Vanesa, Kerzberg, Eduardo, Montoya, Fabiana, Bianchi, Washington, Carneiro, Sueli, Maretti, Giselle Baptista, Bianchi, Dante Valdetaro, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Kahl, Sarah, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chotchaeva, Fatima, Mukhin, Nikolay A., and Moiseev, Sergey
- Abstract
Objective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Results 254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47-5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55-1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56-3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83-9.62]; p=0.019 as compared with controls vs 3 [0.66-5.35]; p=0.012). Conclusion Rituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
- Published
- 2019
16. Incidences and risk factors of organ manifestations in the early course of systemic sclerosis: A longitudinal EUSTAR study
- Author
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Jaeger, Veronika K., Wirz, Elina G., Allanore, Yannick, Rossbach, Philipp, Riemekasten, Gabriela, Hachulla, Eric, Distler, Oliver, Airò, Paolo, Carreira, Patricia E., Gurman, Alexandra Balbir, Tikly, Mohammed, Vettori, Serena, Damjanov, Nemanja, Müller Ladner, Ulf, Distler, Jörg H. W., Mangtao, Li, Walker, Ulrich A., Ananieva, Lidia, Heitmann, Stefan, Rednic, Simona, Riccieri, Valeria, Szmyrka Kaczmarek, Magdalena, Farge, Dominique, Lapadula, Giovanni, Matucci Cerinic, Marco, Guiducci, Serena, Hunzelmann, Nicolas, Ricci, Massimo, Mihai, Carina, Veale, Douglas, Hesselstrand, Roger, Mariok, Eduardo, Smith, Vanessa, Tarner, Ingo H., Kucharz, Eugene J., Czirják, László, Martinovic, Duska, Solanki, Kamal, Ancuta, Codrina Mihaela, Sibilia, Jean, Paola, Caramaschi, Hassanien, Manal, Kahl, Sarah, Wigley, Frederick, Vanthuyne, Marie, Opris, Daniela, Radominski, Sebastião C., Monaco, Andrea Lo, Corrado, Ada, Koehm, Michaela, Codullo, Veronica, Radim, Bevcar, Loyo, Esthela, Üprus, Maria, Pellerito, Raffaele, Zenone, Thierry, Gabrielli, Armando, Kowal Bielecka, Otylia, Rozman, Blaz, Scorza, Raffaella, Saketkoo, Lesley Ann, Midtvedt, Oyvind, Von Mühlen, Carlos Alberto, Henes, Jörg, Branimir, Ani, Hasler, Paul, Yavuz, Sule, Adler, Sabine, Krummel Lorenz, Brigitte, Posa, Magdalena, Engelhart, Merete, Denton, Christopher, Krasowska, Dorota, Lefebvre, Paloma Garcia De La Peña, Cozzi, Franco, Mouthon, Luc, Rosato, Edoardo, Selmi, Carlo, Sancho, Juan José Alegre, Mallia, Carmel, Limonta, Massimiliano, Seidel, Matthias, Foti, Rosario, Stamp, Lisa, Ullman, Susanne, Stebbings, Simon, Santamaria, Vera Ortiz, Del Galdo, Francesco, De Langhe, Ellen, Mathieu, Alessandro, Sunderkötter, Cord, Eyerich, Kilian, Stamenkovic, Bojana, Novak, Srdan, Sampaio Barros, Percival D., Kayser, Cristiane, Litinsky, Ira, Couto, Maura, Jaeger, Veronika K., Wirz, Elina G., Allanore, Yannick, Rossbach, Philipp, Riemekasten, Gabriela, Hachulla, Eric, Distler, Oliver, Airã², Paolo, Carreira, Patricia E., Gurman, Alexandra Balbir, Tikly, Mohammed, Vettori, Serena, Damjanov, Nemanja, Mã¼ller ladner, Ulf, Distler, Jã¶rg H. W., Li, Mangtao, Walker, Ulrich A., Ananieva, Lidia, Heitmann, Stefan, Rednic, Simona, Riccieri, Valeria, Szmyrka kaczmarek, Magdalena, Farge, Dominique, Lapadula, Giovanni, Matucci cerinic, Marco, Guiducci, Serena, Hunzelmann, Nicola, Ricci, Massimo, Mihai, Carina, Veale, Dougla, Hesselstrand, Roger, Mariok, Eduardo, Smith, Vanessa, Tarner, Ingo H., Kucharz, Eugene J., Czirjã¡k, Lã¡szlã³, Martinovic, Duska, Solanki, Kamal, Ancuta, Codrina Mihaela, Sibilia, Jean, Paola, Caramaschi, Hassanien, Manal, Kahl, Sarah, Wigley, Frederick, Vanthuyne, Marie, Opris, Daniela, Radominski, Sebastiã£o C., Monaco, Andrea Lo, Corrado, Ada, Koehm, Michaela, Codullo, Veronica, Radim, Bevcar, Loyo, Esthela, Ãœprus, Maria, Pellerito, Raffaele, Zenone, Thierry, Gabrielli, Armando, Kowal bielecka, Otylia, Rozman, Blaz, Scorza, Raffaella, Saketkoo, Lesley Ann, Midtvedt, Oyvind, Von Mã¼hlen, Carlos Alberto, Henes, Jã¶rg, Branimir, Ani, Hasler, Paul, Yavuz, Sule, Adler, Sabine, Krummel lorenz, Brigitte, Posa, Magdalena, Engelhart, Merete, Denton, Christopher, Krasowska, Dorota, Lefebvre, Paloma Garcia De La Peã±a, Cozzi, Franco, Mouthon, Luc, Rosato, Edoardo, Selmi, Carlo, Sancho, Juan Josã© Alegre, Mallia, Carmel, Limonta, Massimiliano, Seidel, Matthia, Foti, Rosario, Stamp, Lisa, Ullman, Susanne, Stebbings, Simon, Santamaria, Vera Ortiz, Del Galdo, Francesco, De Langhe, Ellen, Mathieu, Alessandro, Sunderkã¶tter, Cord, Eyerich, Kilian, Stamenkovic, Bojana, Novak, Srdan, Sampaio barros, Percival D., Kayser, Cristiane, Litinsky, Ira, Couto, Maura, and University of Zurich
- Subjects
Male ,Genetics and Molecular Biology (all) ,Pulmonology ,Blood Pressure ,Vascular Medicine ,Biochemistry ,Scleroderma ,Diagnostic Radiology ,0302 clinical medicine ,Retrospective Studie ,Longitudinal Studies ,lcsh:Science ,integumentary system ,Incidence ,Arteries ,Systolic Pressure ,3. Good health ,Echocardiography ,Cohort ,Regression Analysis ,Human ,medicine.medical_specialty ,Imaging Techniques ,Gastrointestinal Disease ,Immunology ,1100 General Agricultural and Biological Sciences ,Skin Diseases ,03 medical and health sciences ,FEV1/FVC ratio ,Rheumatology ,1300 General Biochemistry, Genetics and Molecular Biology ,Humans ,Autoantibodies ,Retrospective Studies ,Aged ,1000 Multidisciplinary ,Biochemistry, Genetics and Molecular Biology (all) ,Proportional hazards model ,lcsh:R ,Biology and Life Sciences ,Proteins ,medicine.disease ,Agricultural and Biological Sciences (all) ,Blood Vessels ,lcsh:Q ,Clinical Medicine ,Ejection Fraction ,Lung Diseases ,Kidney Disease ,Physiology ,Gastrointestinal Diseases ,lcsh:Medicine ,Longitudinal Studie ,Kaplan-Meier Estimate ,Medicine (all) ,Lung Disease ,Pericardial effusion ,Risk Factors ,Medizinische Fakultät ,Immune Physiology ,Ultrasound Imaging ,Medicine and Health Sciences ,030212 general & internal medicine ,Pulmonary Arteries ,Connective Tissue Diseases ,Immune System Proteins ,Pulmonary Hypertension ,Multidisciplinary ,Ejection fraction ,Radiology and Imaging ,Incidence (epidemiology) ,10051 Rheumatology Clinic and Institute of Physical Medicine ,Middle Aged ,Autoantibodie ,Heart Disease ,Kidney Diseases ,Female ,Anatomy ,Research Article ,Adult ,Heart Diseases ,Cardiology ,610 Medicine & health ,Research and Analysis Methods ,Antibodies ,Regression Analysi ,Autoimmune Diseases ,Diagnostic Medicine ,Internal medicine ,medicine ,ddc:610 ,030203 arthritis & rheumatology ,Scleroderma, Systemic ,business.industry ,Risk Factor ,Skin Disease ,Raynaud Disease ,Retrospective cohort study ,Surgery ,Cardiovascular Anatomy ,Clinical Immunology ,business - Abstract
Objective Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs. Organ involvement mostly manifests after a variable period of the onset of Raynaud's phenomenon (RP). We aimed to map the incidence and predictors of pulmonary, cardiac, gastrointestinal (GI) and renal involvement in the early course of SSc. Methods In the EUSTAR cohort, patients with early SSc were identified as those who had a visit within the first year after RP onset. Incident SSc organ manifestations and their risk factors were assessed using Kaplan-Meier methods and Cox regression analysis. Results Of the 695 SSc patients who had a baseline visit within 1 year after RP onset, the incident non-RP manifestations (in order of frequency) were: skin sclerosis (75%) GI symptoms (71%), impaired diffusing capacity for monoxide40mmHg (14%), and renal crisis (3%). In the heart, incidence rates were highest for diastolic dysfunction, followed by conduction blocks and pericardial effusion. While the main baseline risk factor for a short timespan to develop FVC impairment was diffuse skin involvement, for PAPsys>40mmHg it was higher patient age. The main risk factors for incident cardiac manifestations were anti-topoisomerase autoantibody positivity and older age. Male sex, anti-RNA-polymerase-III positivity, and older age were risk factors associated with incident renal crisis. Conclusion In SSc patients presenting early after RP onset, approximately half of all incident organ manifestations occur within 2 years and have a simultaneous rather than a sequential onset. These findings have implications for the design of new diagnostic and therapeutic strategies aimed to ‘widen' the still very narrow ‘window of opportunity'. They may also enable physicians to counsel and manage patients presenting early in the course of SSc more accurately.
- Published
- 2016
17. Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study
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Deodhar, Atul, primary, Gottlieb, Alice B, additional, Boehncke, Wolf-Henning, additional, Dong, Bin, additional, Wang, Yuhua, additional, Zhuang, Yanli, additional, Barchuk, William, additional, Xu, Xie L, additional, Hsia, Elizabeth C, additional, AELION, Jacob, additional, AMARELO-RAMOS, Juan, additional, BALSA, Alejandro, additional, BERGHEA, Florian, additional, BRZEZICKI, Jan, additional, BURNETTE, Michael, additional, FRETZIN, Scott, additional, GARCÍA-CARAZO, Sara, additional, GLADSTEIN, Geoffrey, additional, GOMEZ-REINO, Juan, additional, GOODERHAM, Melinda, additional, GONZÁLEZ-FERNÁNDEZ, Carlos, additional, GOTTLIEB, Alice, additional, GRATACOS, Jordi, additional, HAALAND, Derek, additional, KAMALOVA, Rima, additional, LESZCZYNSKI, Piotr, additional, MARTIN-MOLA, Emilio, additional, MASLYANSKY, Alexey, additional, NAVARRO, Federico, additional, OPRIS, Daniela, additional, PAPP, Kim, additional, PERLAMUTROV, Yuriy, additional, PHILIPP, Sandra, additional, RACEWICZ, Artur, additional, REBROV, Andrey, additional, RELL-BAKALARSKA, Maria, additional, ROSMARIN, David, additional, RUBBERT-ROTH, Andrea, additional, SHERGY, William, additional, SHIRINSKY, Ivan, additional, SONIN, Dmitry, additional, STANISLAV, Marina, additional, SUKHAREV, Alexey, additional, TEMNIKOV, Vadim, additional, VINOGRADOVA, Irina, additional, WAYTZ, Paul, additional, and YAKUSHEVICH, Vladimir, additional
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- 2018
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18. Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
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Hartman, Linda, primary, Rasch, Linda A., additional, Klausch, Thomas, additional, Bijlsma, Hans W. J., additional, Christensen, Robin, additional, Smulders, Yvo M., additional, Ralston, Stuart H., additional, Buttgereit, Frank, additional, Cutolo, Maurizio, additional, Da Silva, Jose A. P., additional, Opris, Daniela, additional, Rovenský, Jozef, additional, Szamosi, Szilvia, additional, Middelink, Leonie M., additional, Lems, Willem F., additional, and Boers, Maarten, additional
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- 2018
- Full Text
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19. Update of EULAR recommendations for the treatment of systemic sclerosis
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UMC Utrecht, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Kowal-Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H W, Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicolas, Khanna, Dinesh, Matucci-Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller-Ladner, Ulf, Daikeler, Thomas, Lanciano, Elisabetta, Becvár, Radim, Tomcik, Michal, Gindzienska-Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tünde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic-Krstulovic, Daniela, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Morovic-Vergles, Jadranka, Culo, Melanie I., Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthias F., Klinik, Medizinische, Hasler, Paul, Da Silva, José A Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlos, Midtvedt, Øyvind, Hoffmann-Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre-Sancho, Juan José, Beltran-Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Barešic, Marko, Mayer, Miroslav, üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik-Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma García, Imbert, Bernard, UMC Utrecht, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Kowal-Bielecka, Otylia, Fransen, Jaap, Avouac, Jerome, Becker, Mike, Kulak, Agnieszka, Allanore, Yannick, Distler, Oliver, Clements, Philip, Cutolo, Maurizio, Czirjak, Laszlo, Damjanov, Nemanja, del Galdo, Francesco, Denton, Christopher P., Distler, Jörg H W, Foeldvari, Ivan, Figelstone, Kim, Frerix, Marc, Furst, Daniel E., Guiducci, Serena, Hunzelmann, Nicolas, Khanna, Dinesh, Matucci-Cerinic, Marco, Herrick, Ariane L., van den Hoogen, Frank, van Laar, Jacob M., Riemekasten, Gabriela, Silver, Richard, Smith, Vanessa, Sulli, Alberto, Tarner, Ingo, Tyndall, Alan, Welling, Joep, Wigley, Frederic, Valentini, Gabriele, Walker, Ulrich A., Zulian, Francesco, Müller-Ladner, Ulf, Daikeler, Thomas, Lanciano, Elisabetta, Becvár, Radim, Tomcik, Michal, Gindzienska-Sieskiewicz, Ewa, Iudici, Michele, Rednic, Simona, Vlachoyiannopoulos, Panayiotis G., Caporali, Roberto, Carreira, Patricia E., Novak, Srdan, Minier, Tünde, Kucharz, Eugene J., Gabrielli, Armando, Moroncini, Gianluca, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Radic, Mislav, Marasovic-Krstulovic, Daniela, Braun-Moscovici, Yolanda, Monaco, Andrea Lo, Morovic-Vergles, Jadranka, Culo, Melanie I., Henes, Jörg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Michalska-Jakubus, Malgorzata, Seidel, Matthias F., Klinik, Medizinische, Hasler, Paul, Da Silva, José A Pereira, Salvador, Maria J., Stamenkovic, Bojana, Stankovic, Aleksandra, Tikly, Mohammed, Ananieva, Lidia P., Beretta, Lorenzo, Szucs, Gabriella, Szamosi, Szilvia, de la Puente Bujidos, Carlos, Midtvedt, Øyvind, Hoffmann-Vold, Anna Maria, Launay, David, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra, Opris, Daniela, Mihai, Carina, Herrgott, Ilka, Beyer, Christian, Ingegnoli, Francesca, von Mühlen, Carlos Alberto, Alegre-Sancho, Juan José, Beltran-Catalan, Emma, Aringer, Martin, Fantana, Julia, Leuchten, Nicolai, Tausche, Anne Kathrin, Langhe, Ellen De, Vanthuyne, Marie, Anic, Branimir, Barešic, Marko, Mayer, Miroslav, üprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Jimenez, Sergio A., Popa, Serghei, Agachi, Svetlana, Zenone, Thierry, Stebbings, Simon, Dockerty, Joanne, Vacca, Alessandra, Schollum, Joanna, Veale, Douglas J., Toloza, Sergio, Xu, Dong, Olas, Jacek, Rosato, Edoardo, Foti, Rosario, Adler, Sabine, Dan, Diana, Wiesik-Szewczyk, Ewa, Olesinska, Marzena, Kayser, Cristiane, Fathi, Nihal, de la Peña Lefebvre, Paloma García, and Imbert, Bernard
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- 2017
20. Original papers: clinical or basic research anti-cyclic citrullinated peptide antibodies - activity markers in rheumatoid arthritis
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Predeteanu, Denisa, Varzaru, Luminita, Balanescu, Andra, Bojinca, Violeta, Opris, Daniela, Vlad, Violeta, Berghea, Florian, Abobului, Mihai, Constantinescu, Cosmin, and Ionescu, Ruxandra
- Subjects
musculoskeletal diseases ,rheumatoid arthritis ,Adult ,Male ,anti-cyclic cytrullinated peptide antibodies ,Romania ,Original Articles ,Middle Aged ,Peptides, Cyclic ,rheumatoid factor ,Arthritis, Rheumatoid ,immune system diseases ,Case-Control Studies ,Rheumatic Diseases ,Humans ,Female ,skin and connective tissue diseases ,Biomarkers ,Aged ,Autoantibodies ,Retrospective Studies - Abstract
Background: Immunological abnormalities in rheumatoid arthritis (RA) imply several antibodies, among which anti-cyclic cytrullinated peptide antibodies (anti-CCP) have the highest sensitivity and specificity. Their diagnostic and prognostic value in RA is well known, although their value as markers of the disease activity has not been established yet. Objectives: The aim of this study is to evaluate the correlation between anti-CCP antibodies and RA activity which eventually leads to the best treatment of choice. Patients and Methods: 217 consecutive patients hospitalized in the Department of Internal Medicine and Rheumatology, “Sf. Maria” Clinical Hospital between 01.01-31.06 2007 were retrospectively studied. They were divided into two groups: group A-111 patients with RA (ACR criteria fulfilled) and group B-106 patients with other rheumatic diseases. The following parameters taken out of the patients, files were studied: parameters of the clinical activity of disease (C reactive protein, fibrinogen), rheumatoid factor (RF) and anti-CCP antibodies. Disease activity score (DAS) using 4 variables (number of tender joints, number of swollen joints, erythrocyte sedimentation rate and assessement of the disease activity) was also studied. Data were processed with SPSS program using linear functions, Pearson correlation coefficient and Hi2 test of interdependency. Results: The sensitivity of anti-CCP antibodies in patients with RA was 56.75%. The specificity of anti-CCP antibodies in patients with RA was 90.56%. Low seric levels of anti-CCP antibodies were also found in patients without RA, but with other conditions like: osteoarthritis, viral polyarthritis, infectious myositis and Still disease; moderate to high seric levels were found in patients with psoriatic arthritis. Significant correlations were found between anti-CCP antibodies and DAS (r=0.437), between anti-CCP and fibrinogen (r=0,32) between anti-CCP antibodies and C reactive protein (r=0,237) as well as between anti-CCP and RF (r=0, 38). Conclusions: Anti-CCP antibodies are highly specific but moderately sensitive for RA, their highest frequencies and seric levels being found in seropositive RA. Anti-CCP can be used in patients with RA not only as a diagnostic marker but also as a reliable test for assessing the activity of the disease.
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- 2009
21. Treatment of Anterior Instability of the Shoulder
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Vlase, Marius, Ene, Razvan, Opris, Daniela, and Cirstoiu, Catalin
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Original Papers - Abstract
The aim of this study is to compare the long term results of the treatment of anterior instability of the shoulder.The study included a total of 37 patients diagnosed with anterior instability of the shoulder, on the basis of clinical data (anamnesis, physical examination) and imaging (X-rays, MRI examination), operated in the Department of Orthopedics and Traumatology - Emergency University Hospital Bucharest, Romania, between 2009-2012. They were divided in 3 groups, according to the surgical technique used (open Bankart, arthroscopic Bankart and Bristow procedure), and the results were evaluated at 2 years postoperatively using Rowe and Constant scores. Statistical analysis was performed using one-way ANOVA test.There were no intra- or postoperative complications. No reluxations were recorded. Statistically significant differences (FFcrit; p0.05) of the Constant score were recorded between the three groups on the range of movement variable, especially external rotation, their mean values being higher in the group treated arthroscopically compared to the other two groups.Arthroscopic shoulder stabilization surgery gives the best long time results in terms of functional recovery of the shoulder, objectified by Constant and Rowe scores. Data from the literature show a higher rate of recurrence after arthroscopic interventions, suggesting that the indications of this technique still requires further clarifications. It's required a more precise preoperative evaluation, in order to detect any lesions associated with Bankart lesion (bone defects of the anterior rim of glenoid, Hill-Sachs lesion, capsular laxity, rotator cuff tears, long head of biceps injuries). Mastering a surgical techniques is not always enough in order to obtain the best results. The choice of proper surgical technique for each patient, however, can significantly reduce the recurrence rate of shoulder dislocation.
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- 2015
22. Dual X-Ray Absorptiometry Whole Body Composition of Bone Tissue in Rheumatoid Arthritis – a Cross-Sectional Study
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POPESCU, Claudiu, BOJINCA, Violeta, OPRIS, Daniela, and IONESCU, Ruxandra
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Case Reports - Published
- 2015
23. Low vitamin D status in systemic sclerosis and the impact on disease phenotype
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Groseanu, Laura, primary, Bojinca, Violeta, additional, Gudu, Tania, additional, Saulescu, Ioana, additional, Predeteanu, Denisa, additional, Balanescu, Andra, additional, Berghea, Florian, additional, Opris, Daniela, additional, Borangiu, Andreea, additional, Constantinescu, Cosmin, additional, Negru, Magda, additional, and Ionescu, Ruxandra, additional
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- 2016
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24. Improved clinical, functional and work outcomes in spondyloarthritides during real-life adalimumab treatment in central–eastern Europe
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Szántó, Sándor, primary, Poór, Gyula, additional, Opris, Daniela, additional, Iaremenko, Oleg, additional, Procházková, Leona, additional, Kuuse, Reet, additional, Nagy, Orsolya, additional, Chernyshov, Valentyn, additional, and Géher, Pál, additional
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- 2016
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25. A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study
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Ingegnoli, Francesca, primary, Boracchi, Patrizia, additional, Gualtierotti, Roberta, additional, Smith, Vanessa, additional, Cutolo, Maurizio, additional, Foeldvari, Ivan, additional, Airò, Paolo, additional, Alegre-Sancho, Juan Jose, additional, Allanore, Yannick, additional, Ananieva, Lidia P., additional, Ancuta, Codrina, additional, Andrade, Luis Eduardo, additional, Aringer, Martin, additional, Becvar, Radim, additional, Bojinca, Mihai, additional, Butrimiene, Irena, additional, Cantatore, Francesco Paolo, additional, Caporali, Roberto, additional, Caramaschi, Paola, additional, Carreira, Patricia E., additional, Chirieac, Rodica, additional, Corrado, Ada, additional, Cosentino, Vanesa, additional, Cuomo, Giovanna, additional, Czirjak, Laszlo, additional, Da Silva, José Antonio Pereira, additional, la Peña Lefebvre, Paloma García de, additional, De Keyser, Filip, additional, de Souza Müller, Carolina, additional, Damgaard, Kirsten, additional, Damjanov, Nemanja, additional, Denisov, Lev N., additional, Distler, Oliver, additional, Doube, Alan, additional, Dumitrascu, Alina, additional, Engelhart, Merete, additional, Exposito, Marta Valero, additional, Eyerich, Kilian, additional, Farge-Bancel, Dominique, additional, Azevedo, Valderílio Feijó, additional, Foti, Rosario, additional, Frerix, Marc, additional, Gabrielli, Armando, additional, Garen, Torhild, additional, Gottschalk, Paola, additional, Groseanu, Laura, additional, Guiducci, Serena, additional, Günther, Claudia, additional, Hachulla, Eric, additional, Hein, Rüdiger, additional, Heitmann, Stefan, additional, Henes, Jörg, additional, Hesselstrand, Roger, additional, Highton, John, additional, Iannone, Florenzo, additional, Ionescu, Ruxandra Maria, additional, Kayser, Cristiane, additional, Karpec, Diana, additional, Kerzberg, Eduardo, additional, Kotulska, Anna, additional, Kopec-Medrek, Magdalena, additional, Kucharz, Eugene, additional, Krummel-Lorenz, Brigitte, additional, Lauffer, Felix, additional, Launay, David, additional, Li, Mengtao, additional, Litinsky, Ira, additional, Loyo, Esthela, additional, Cerinic, Marco Matucci, additional, Meroni, Pierluigi, additional, Midtvedt, Øyvind, additional, Mihai, Carmen Marina, additional, Montecucco, Carlomaurizio, additional, Montoya, Fabiana, additional, Morgiel, Ewa, additional, Mouthon, Luc, additional, Müller-Ladner, Ulf, additional, Nielsen, Henrik, additional, Opris, Daniela, additional, Ortiz-Santamaria, Vera, additional, Otsa, Kati, additional, Pileckyte, Margarita, additional, Pisarri, Simonetta, additional, Popescu, Monica, additional, Pozzi, Maria Rosa, additional, Puppo, Francesco, additional, Radominski, Sebastião Cezar, additional, Riccieri, Valeria, additional, Rosato, Edoardo, additional, Rozman, Blaz, additional, Rubio, Silvia Rodriguez, additional, Rugiene, Rita, additional, Saar, Petra, additional, Salvador, Maria João, additional, Seidel, Matthias, additional, Sokolik, Renata, additional, Solanki, Kamal, additional, Stamenkovic, Bojana, additional, Stankovic, Aleksandra, additional, Stebbings, Simon, additional, Strauss, Gitte, additional, Sulli, Alberto, additional, Szamosi, Szilvia, additional, Szechinski, Jacek, additional, Szmyrka-Kaczmarek, Magdalena, additional, Szücs, Gabriella, additional, Tanaseanu, Cristina-Mihaela, additional, Tiglea, Isabela, additional, Tyndall, Alan, additional, Ughi, Nicola, additional, Uprus, Maria, additional, Vacca, Alessandra, additional, Varju, Cecilia, additional, Venalis, Algirdas, additional, Venalis, Paulius, additional, Walker, Ulrich A., additional, Widuchowska, Malgorzata, additional, Wiland, Piotr, additional, Wuttge, Dirk M., additional, Zeni, Silvana, additional, and Zenone, Thierry, additional
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- 2015
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26. Serum serotonin: useful for the assessment of the bone metabolism status?
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Poiana, Catalina, primary, Carsote, Mara, additional, Radoi, Valentin, additional, Mihai, Alexandra, additional, Geleriu, Andreea, additional, Capatana, Cristina, additional, Trifanescu, Raluca, additional, and Opris, Daniela, additional
- Published
- 2014
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27. A1.27 Serum rituximab level and other predictors for good eular response before re-treatment in rheumatoid arthritis
- Author
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Mazilu, Diana, primary, Gainaru, Cecilia, additional, Apetrei, Natalia, additional, Luca, Georgiana, additional, Gudu, Tania, additional, Peltea, Alexandra, additional, Groseanu, Laura, additional, Constantinescu, Cosmin, additional, Saulescu, Ioana, additional, Bojinca, Violeta, additional, Balanescu, Andra, additional, Predeteanu, Denisa, additional, Ionescu, Ruxandra, additional, and Opris, Daniela, additional
- Published
- 2014
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28. A1.85 Can rituximab treatment in rheumatoid arthritis patients decrease cardiovascular risk?
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Gudu, Tania, primary, Mazilu, Diana, additional, Peltea, Alexandra, additional, Opris, Daniela, additional, and Ionescu, Ruxandra, additional
- Published
- 2014
- Full Text
- View/download PDF
29. A1.4 Predictive factors for the eular response in ra patients with rituximab treatment
- Author
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Peltea, Alexandra, primary, Mazilu, Diana, additional, Gudu, Tania, additional, Opris, Daniela, additional, and Ionescu, Ruxandra, additional
- Published
- 2014
- Full Text
- View/download PDF
30. Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients
- Author
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Mazilu, Diana, primary, Gudu, Tania, additional, Ionescu, Ruxandra, additional, and Opris, Daniela, additional
- Published
- 2014
- Full Text
- View/download PDF
31. SAT0196 Vitamin D Status and Clinical Significance in a Group of Scleroderma Patients
- Author
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Groseanu, L., primary, Saulescu, Ioana, additional, Balanescu, Andra, additional, Bojinca, Violeta, additional, Opris, Daniela, additional, Constantinescu, Cosmin, additional, Berghea, Florian, additional, Abobului, Mihai, additional, Predeteanu, Denisa, additional, and Ionescu, Ruxandra, additional
- Published
- 2013
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32. COMPARISON OF NON-RADIOGRAPHIC SPONDYLOARTHRITIS VERSUS ANKYLOSING SPONDYLITIS PATIENTS UNDERGOING BIOLOGICAL THERAPY - DATA FROM A ROMANIAN COHORT.
- Author
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Deaconu, Claudia, Opris, Daniela, and Ionescu, Ruxandra
- Subjects
- *
SPONDYLITIS , *ARTHRITIS , *ANKYLOSING spondylitis , *BIOTHERAPY , *X-rays , *PATIENTS - Abstract
Both non-radiographic spondyloarthritis (nr-SpA) and ankylosing spondylitis (AS) are medical conditions that belong to the axial spondyloarthritis spectrum; these two terms reveal the extent of sacroiliitis assessed by conventional x-ray or MRI. According to the latest classification criteria (ASAS, 2009), clinicians are able to differentiate patients with nr-SpA from AS and to follow their disease progression. The present study aims to compare the two patient categories undergoing biological therapy with an anti-TNF agent and indicate distinct disease features. We included 94 patients in treatment with IFX, ADL, ETA or GOL and monitored clinical, biological and disease activity parameters. The nr-SpA subgroup included a higher percentage of female patients; AS patients presented higher values of the CRP at follow-up visits; there were no significant differences between the two groups regarding the HLA-B27 presence, uveitis history or smoking status. Patients with an inactive disease status had a lower BMI, shorter disease duration and an early initiation of biological therapy so that we suggest a close and regular monitoring of these two entities. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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33. ASSESSING ANTI-TNF TROUGH LEVELS AND ITS APPLICABILITY IN DAILY PRACTICE IN SPONDYLOARTHRITIS PATIENTS.
- Author
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Deaconu, Claudia, Opris, Daniela, and Ionescu, Ruxandra
- Subjects
- *
SPONDYLITIS , *TUMOR necrosis factors , *TREATMENT of arthritis , *DRUG monitoring , *INDIVIDUALIZED medicine , *STATISTICAL correlation , *ENZYME-linked immunosorbent assay , *THERAPEUTICS - Abstract
Objective. The purpose of the present study was to assess the relevance of therapeutic drug monitoring in spondyloarthritis patients, by determining drug serum levels and anti-drug antibodies and estimating cut-off values for three TNF inhibitors. Methods. Over one year, we enrolled 100 patients with SpA, under consequent treatment with adalimumab (ADL), etanercept (ETA) or infliximab (IFX). Demographic, clinical (BASDAI, ASDAS) and laboratory (ESR, CRP) data was collected together with drug serum level and anti-drug antibodies using the ELISA technique. The statistical analysis was performed using the SPSS software, version 20.0 with the aid of Student t-test, Spearman and Pearson tests. Results. Out of the study cohort, 35% were on ADL, 33% on IFX, and 32% under ETA treatment. Undetectable drug levels correlated to the presence of anti-drug antibodies and to disease activity scores. There were no identified anti-ETA antibodies. For this study lot trough levels are estimated between 2 and 4 μg/mL for an ASDAS-CRP under 2.1. Conclusion. Serum drug level measurement and anti-drug antibody detection can be used as a completion to a clinician's tools in assessing disease activity, leading to an optimal and personalized manner of patient management. [ABSTRACT FROM AUTHOR]
- Published
- 2016
34. THE IMMUNOGENICITY ERA - WHAT SHOULD WE KNOW ON ANTI-TNFS IN SPONDYLOARTHRITIS PATIENTS?
- Author
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Deaconu, Claudia, Opris, Daniela, and Ionescu, Ruxandra
- Subjects
- *
ARTHRITIS patients , *TUMOR necrosis factors , *IMMUNOGLOBULINS , *ANTI-drug advertising , *PATHOLOGICAL physiology - Abstract
Spondyloarthritis (SpA) patients do not respond uniformly to TNF inhibitor therapy, some of them losing their beneficial evolution and becoming primary or secondary non-responders. Hence, questions have been raised whether this situation is linked to predictive genetic factors, individual characteristics or to disease activity. Studies have incriminated immunogenicity as being responsible for the loss or lack of response. It appears that the development of anti-drug antibodies leads to a decrease in drug levels with further impact on patients' clinical state. This brief review aims to clarify some of the processes involved in the immunogenic phenomenon for patients with SpA, based on the current published literature. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
35. OPTIMIZING EXISTING TOOLS FOR REACHING AN ADEQUATE DISEASE CONTROL IN PATIENTS WITH SPONDYLOARTHRITIS.
- Author
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Deaconu, Claudia, Opris, Daniela, Mazilu, Diana, Groseanu, Laura, Borangiu, Andreea, Ioana, Saulescu, Peltea, Alexandra, Negru, Magdalena, Constantinescu, Cosmin, Vlad, Violeta, Bojinca, Violeta, Balanescu, Andra, Predeteanu, Denisa, and Ionescu, Ruxandra
- Subjects
- *
ARTHRITIS , *TUMOR necrosis factors , *ANALYSIS of variance , *POLYMERASE chain reaction , *SINGLE nucleotide polymorphisms - Abstract
Background/Objective. Disease activity in spondyloarthritis (SpA) is evaluated through conventional scores such as BASDAI or ASDAS. The aim of this study was to determine disease activity in SpA patients under biological therapy with further assessment on the quality of each activity indicator and their clinical value together with their impact on NSAID intake. Materials and methods. Over nine months (January-August 2015) we enrolled 100 patients with SpA on anti- TNF therapy (33% IFX; 35% ADL; 32% ETA). We collected demographic, clinical (BASDAI, ASDAS, PtGA) and laboratory data (ESR, CRP). Frequency of NSAID ingestion expressed as days per week was included in a questionnaire. Considering their biologic treatment, patients were divided into disease activity groups and sample characteristics were correlated and compared. Statistical analysis was performed with SPSS 20.0, using specific tests such as Pearson, Spearman or ANOVA. Results. Patients with active disease, stated by both activity scores had an increased NSAID intake. Out of 86% of patients with a BASDAI under 4, only 82.6% had an ASDAS-CRP lower than 1.3. BASDAI correlated to both ASDAS scores (r = 0.65 and 0.71, P<0.001) and PtGA correlated to both disease activity scales, with a stronger correlation to BASDAI (r = 0.912, P<0.01) than ASDAS (r = 0.67 and 0.71, P<0.01 for both). Conclusion. We proved that disease activity scores have good discriminatory power, with a strong correlation between the subjective BASDAI and PtGA. However, ASDAS-CRP proves to be more rigorous than other variables when targeting high and low disease activity, thus indicating the need of an objective component in assessing these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
36. Artifacts and Pitfalls in DXA Scan Images and Interpretation
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Bojinca, Violeta, primary, Opris, Daniela, additional, and Bojinca, Mihai, additional
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- 2012
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37. Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients
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Besliu, Alina, primary, Banica, Leontina, additional, Predeteanu, Denisa, additional, Vlad, Violeta, additional, Ionescu, Ruxandra, additional, Pistol, Gina, additional, Opris, Daniela, additional, Berghea, Florian, additional, Stefanescu, Maria, additional, and Matache, Cristiana, additional
- Published
- 2011
- Full Text
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38. Oxidative stress markers for monitoring secondary effects of rheumatoid arthritis treatments
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Negrei, Carolina, primary, Balalau, Dan, additional, Baconi, Daniela, additional, Margina, Denisa, additional, Ilie, Mihaela, additional, Balanescu, Andra, additional, Berghea, Florian, additional, Bojinca, Violeta, additional, Opris, Daniela, additional, Predeteanu, Denisa, additional, and Ionescu, Ruxandra, additional
- Published
- 2009
- Full Text
- View/download PDF
39. Additional file 1: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
Protocol for sub-study of medication adherence. (DOCX 14Â kb)
40. Additional file 2: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
SPIRIT Checklist. (DOC 121Â kb)
41. Additional file 4: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
List of ethical committees that approved the GLORIA trial. (DOCX 13Â kb)
42. Additional file 1: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
Protocol for sub-study of medication adherence. (DOCX 14Â kb)
43. Additional file 4: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
List of ethical committees that approved the GLORIA trial. (DOCX 13Â kb)
44. Additional file 2: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
SPIRIT Checklist. (DOC 121Â kb)
45. Additional file 3: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
Full list of outcome measures: benefit, harm, and cost-utility. (DOCX 32Â kb)
46. Additional file 3: of Harm, benefit and costs associated with low-dose glucocorticoids added to the treatment strategies for rheumatoid arthritis in elderly patients (GLORIA trial): study protocol for a randomised controlled trial
- Author
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Hartman, Linda, Rasch, Linda, Klausch, Thomas, Bijlsma, Hans, Christensen, Robin, Smulders, Yvo, Ralston, Stuart, Buttgereit, Frank, Cutolo, Maurizio, Silva, Jose Da, Opris, Daniela, RovenskĂ˝, Jozef, Szamosi, Szilvia, Middelink, Leonie, Lems, Willem, and Boers, Maarten
- Subjects
3. Good health - Abstract
Full list of outcome measures: benefit, harm, and cost-utility. (DOCX 32Â kb)
47. PULMONARY NON-HODGKIN LYMPHOMA IN A PRIMARY SJÖGREN SYNDROME PATIENT.
- Author
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Deaconu, Claudia, Ionescu, Ruxandra, and Opris, Daniela
- Subjects
- *
LYMPHOMAS , *AUTOIMMUNE diseases , *DISEASE incidence , *RITUXIMAB , *SINGLE nucleotide polymorphisms - Abstract
Sjögren syndrome (SS) is a chronic autoimmune condition that mainly targets exocrine glands where it produces lymphocytic infiltrates. The clinical display varies in severity and can include malignancy association such as non-Hodgkin lymphoma. Its incidence ranges from 5 to 8%, while the risk of occurrence is 16 to 44 times higher. This article aims to describe the evolution of a patient with primary SS who developed pulmonary lymphoma for which she received Rituximab as part of the oncological therapeutic scheme. During the course of the disease she developed membranous glomerulonephritis, rarely described in these patients and low complement levels cited as predictive factor for lymphoproliferation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
48. DISEASE ACTIVITY PREDICTS WHOLE BODY AND REGIONAL LEAN TISSUE IN RHEUMATOID ARTHRITIS - A CROSS-SECTIONAL STUDY.
- Author
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Popescu, Claudiu, Bojinca, Violeta, Opris, Daniela, and Ionescu, Ruxandra
- Subjects
- *
RHEUMATOID arthritis diagnosis , *RHEUMATOID arthritis , *RHEUMATOID arthritis treatment , *DUAL-energy X-ray absorptiometry , *POSTMENOPAUSE , *CROSS-sectional method , *PATIENTS - Abstract
Aim. The study aims to assess the potential infl uences of rheumatoid arthritis (RA) and its specifi c disease measures on lean body composition phenotypes of female patients. Methods. The study was cross-sectionally designed to include Caucasian postmenopausal female RA patients and age-matched postmenopausal female controls. All the subjects gave written informed consent and the study was approved by the local ethics committee. Each subject underwent in the same day a clinical examination, laboratory tests, whole body dual X-ray absorptiometry (DXA) composition and physical activity estimation using a self-administered questionnaire. Correlations, differences and predictive power were analyzed with appropriate statistical tests. Results. The study included 107 RA patients and 104 controls. Compared to the normal subjects, who recorded higher levels of physical activity, the RA patients had signifi cantly lower appendicular lean tissue absolute and relative indices and higher prevalence of sarcopenia. The whole body and appendicular lean tissue indices showed signifi cant negative correlations with measures of disease severity (duration, infl ammation, quality of life and radiographic progression), independent of age, levels of physical activity, body mass index and smoking. Conclusions. The measures of disease activity and severity independently predict lean tissue phenotypes in RA patients, behaving as risk factors for sarcopenia and rheumatoid cachexia. The diagnosis of RA in itself is a signifi cant predictive factor of sarcopenia. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
49. FACTORS ASSOCIATED WITH SEVERITY OF DISEASE IN PSORIATIC ARTHRITIS: A CROSS-SECTIONAL STUDY.
- Author
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Gudu, Tania, Peltea, Alexandra, Balanescu, Andra, Bojinca, Violeta, Opris, Daniela, Predeteanu, Denisa, and Ionescu, Ruxandra
- Subjects
- *
DISEASE prevalence , *PSORIATIC arthritis , *LOGISTIC regression analysis , *ADRENOCORTICAL hormones , *SKIN diseases , *DISEASE risk factors , *THERAPEUTICS - Abstract
Objectives. The objectives of this study were to evaluate the prevalence of disease severity in PsA and to assess the factors that might explain it. Methods. This was a cross-sectional study of unselected PsA patients. Severity was defined according to GRAPPA criteria of severity. Factors potentially associated with severity (demographical, clinical, laboratory variables, treatment related factors and comorbidities) were assessed by uni- and multivariate logistic regressions. Results. A total of 129 PsA patients were analysed: 77 (59.7%) women, mean±standard deviation age 53.5±11.8 years, and mean disease duration 7±7.4 years. Twenty-for patients (18.6%) had severe PsA. In the univariate regression, disease severity was associated with psoriasis duration, PsA duration, current moderate/severe skin disease, nail disease, history of corticotherapy, and total number of previous synthetic and biologic DMARDs. In the multivariate analysis, PsA severity was explained by the presence of current moderate/severe psoriasis - odds ratio 5.88 (95% confidence interval 1.39; 25.00) and history of corticosteroids - 4.65 (1.13; 18.87). Conclusion. PsA severity is best explained by the presence of moderate or severe psoriasis and past treatment with corticosteroids, but further longitudinal studies are needed to identify predictive factors. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
50. IS THERE AN EARLY ULTRASONOGRAPHIC PATTERN IN SALIVARY GLANDS IN BOTH PRIMARY AND SECONDARY SJÖGREN SYNDROME?
- Author
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Iorgoveanu, Vasilia, Bojinca, Violeta, Gheorghe, Madalina, MaziluYu, Diana ., Vlad, Violeta, Saulescu, Ioana, Groseanu, Laura, Opris, Daniela, Balanescu, Andra, Constantinescu, Cosmin, Predeteanu, Denisa, and Ionescu, Ruxandra
- Subjects
- *
EXOCRINE glands , *ULTRASONIC imaging , *LYMPHOCYTIC leukemia , *PLANT parenchyma , *PAROTID gland diseases , *SURGERY , *THERAPEUTICS , *LEUKEMIA treatment - Abstract
Background. Sjögren syndrome (SS) is a systemic chronic inflammatory disorder characterized by lymphocytic infiltrates in exocrine organs. Ultrasonography (US) demonstrates specificity and sensibility in major salivary glands (SG) evaluation. Recent data confirm US might be used as primary evaluation technique for its ability to show structural alterations of parenchyma (1). Objective. To assess the gray scale (GS) parenchymal inhomogeneity of major SG in patients with established primary and secondary SS and correlate with clinical and biological data. Methods. Consecutive patients with SS were recruited and SG US was performed. Inhomogeneity of glandular parenchyma was quantified binary on each gland. ESSDAI and ESSPRI scores were calculated. Statistics was performed with SPSS. Results. Twenty one (42.85% primary SS, 90.47% female) consecutive patients were included. Mean age was 53.66+/-12.99 years and disease duration 5.33+/-3.74 years. Antibody SSA/SSB presence was found in 85.7% (18/21). ESSDAI mean was 8.67+/-8.9 (0-29), ESSPRI 10.13+/-5.59(0-20). There were no differences regarding ESSDAI and ESSPRI in the two groups (primary and secondary SS). Right parotid gland showed alterations in 71.4% patients (77% with primary SS, 66% with secondary SS). Frequently inhomogeneity was found in all major SG (33%, 22% left and right submandibular, 77%, 44.4% left and right parotid glands) in primary SS. Both submandibular glands were symmetrically involved (p<0.02). Duration of disease was negatively correlated to inhomogeneity of right parotid gland (p<0.02). Conclusion. Inhomogeneity in major SG in GS US was found in the majority of patients with primary and secondary SS. The symmetrical involvement of submandibular glands was significant. The inhomogeneity appears in the early period of diagnosis. No major differences were found between two groups. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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