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Die transmastoidale/transpyramidale, retrolabyrinthäre Neurektomie des Nervus vestibularis wurde entwickelt (Oppel,1984), um in Fällen einer ineffektiven medikamentösen (Betahistin, Gentamycin) oder chirurgischen Therapie (Saccotomie) die Schwindelsymptomatik bei der Menière’schen[for full text, please go to the a.m. URL], 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Survival of glioblastoma patients has been linked to the completeness of surgical resection. Available data, however, were generated with adjuvant radiotherapy. Data confirming that extensive cytoreduction remains beneficial to patients treated with the current standard, concomitant temozolomide radiochemotherapy, are limited. We therefore analyzed the efficacy of radiochemotherapy for patients with little or no residual tumor after surgery. In this prospective, non-interventional multicenter cohort study, entry criteria were histological diagnosis of glioblastoma, small enhancing or no residual tumor on post-operative MRI, and intended temozolomide radiochemotherapy. The primary study objective was progression-free survival; secondary study objectives were survival and toxicity. Furthermore, the prognostic value of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation was investigated in a subgroup of patients. One-hundred and eighty patients were enrolled. Fourteen were excluded by patient request or failure to initiate radiochemotherapy. Twenty-three patients had non-evaluable post-operative imaging. Thus, 143 patients qualified for analysis, with 107 patients having residual tumor diameters ≤1.5 cm. Median follow-up was 24.0 months. Median survival or patients without residual enhancing tumor exceeded the follow-up period. Median survival was 16.9 months for 32 patients with residual tumor diameters >0 to ≤1.5 cm (95% CI: 13.3–20.5, p = 0.039), and 13.9 months (10.3–17.5, overall p 1.5 cm. Patient age at diagnosis and extent of resection were independently associated with survival. Patients with MGMT promoter methylated tumors and complete resection made the best prognosis. Completeness of resection acts synergistically with concomitant and adjuvant radiochemotherapy, especially in patients with MGMT promoter methylation. Electronic supplementary material The online version of this article (doi:10.1007/s11060-012-0798-3) contains supplementary material, which is available to authorized users.

Einleitung: Eine isolierte Parese des Nervus hypoglossus ist ein in der Literatur selten beschriebenes Symptom. Betroffene Patienten weisen eine Hypomobilität, Faszikulationen und eine Deviation der Zunge zur Seite der Läsion mit einer Atrophie der Zungenmuskulatur der paretischen Seite auf.[for full text, please go to the a.m. URL], 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Objective: Recently, we have detected the stem cell marker SOX2 in a subset of tumor cells in glioblastoma multiforme (GBM). SOX2 represents a transcription factor which has attracted growing attention since it contributes to the maintenance of pluripotent adult neural stem cells. Its expression in [for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien

Objective: Epilepsy surgery in patients with tumours aims to remove the tumour itself and the epileptogenic zone. Our centre has developed an approach to lesions located in the apex of the temporal lobe “apical temporal resection” (aTLR); this resection is based on tailored resection of[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien