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9 results on '"Oostindjer, Andrew"'

2. Comparing the diagnostic considerations between general practitioners with a special interest in cardiovascular disease and those without in patients with symptoms suggestive of heart failure: a vignette study

Author

HAG Hart- Vaatziekten, HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Academische werkplaats huisartsenzorg, Vermeer, Cornelia J.C., Groenewegen, Amy, Hollander, Monika, Schuring, Janneke, Looijmans–van den Akker, Ingrid, Oostindjer, Andrew, van Duijn, Huug, Nederend, Ineke, Rutten, Frans H., HAG Hart- Vaatziekten, HAG Zorginnovatieonderzoek, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Academische werkplaats huisartsenzorg, Vermeer, Cornelia J.C., Groenewegen, Amy, Hollander, Monika, Schuring, Janneke, Looijmans–van den Akker, Ingrid, Oostindjer, Andrew, van Duijn, Huug, Nederend, Ineke, and Rutten, Frans H.

Published
2024

3. Screening over 100 000 patients in 39 general practices in the Netherlands for anticoagulation underprescription in atrial fibrillation: a descriptive, cross-sectional study

Author

Voorhout, Leonard, primary, Pisters, Ron, additional, Geurts, Constants H P H, additional, Oostindjer, Andrew, additional, van Doorn, Sander, additional, Rila, Harrie, additional, Fuijkschot, Wessel W, additional, Verheugt, Freek, additional, and Hemels, Martin E W, additional

Published
2023
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9. [Bempedoic acid, a new cholesterol-lowering agent].

Author

Oostindjer A and Roeters van Lennep JE

Subjects
Humans, Proprotein Convertase 9, Cholesterol, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Hyperlipidemias
Abstract

Statins have been de cornerstone for the treatment of hyperlipidaemia for decades now. More recently the introduction of the PCSK9 inhibitors, inclisiran and even more recently bempedoic acid have given us new options for the treatment of hyperlipidaemia. Bempedoic acid is a prodrug which is metabolized in the liver and not in the peripheral tissues like muscles, this means that myalgia does not occur as a side effect. Its effect on the cholesterol synthesis occurs earlier in the chain of events than that of statins which work primarily via HMGcoA reductase. Other than that is has more or less the same effect as a statin. Next to cholesterol lowering effect it has a dampening effect on inflammation another important link in atherosclerosis. Bempedoic acid is cheap making it the drug of choice after statins and ezetimibe.

Published
2023

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