48 results on '"Onuoha, Shimobi"'
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2. Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR
3. CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial
4. Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR
5. Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction
6. Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein–Protein Interaction
7. A Rapamycin-Activated Caspase 9-Based Suicide Gene
8. An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma
9. Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
10. Mapping the conformational changes that occur in Hsp90 upon cofactor binding
11. Designer small molecule control system based on Minocycline induced disruption of protein-protein interaction.
12. A primer set for the rapid isolation of scFv fragments against cell surface antigens from immunised rats
13. Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy
14. AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies
15. Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy
16. Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis
17. Targeting the T cell receptor [beta]-chain constant region for immunotherapy of T cell malignancies
18. Anti-CD21 Chimeric Antigen Receptor T cells for the Treatment of T Cell Acute Lymphoblastic Leukemia
19. Trojan horses and guided missiles: targeted therapies in the war on arthritis
20. Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies
21. A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency
22. Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL)
23. A High Sensitivity aCD22 CAR Combined with aCD19 CAR to Generate Dual Targeting CAR T Cells for the Treatment of r/r B-ALL
24. Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants
25. Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants
26. Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis
27. Optimised Method for the Production and Titration of Lentiviral Vectors Pseudotyped with the SARS-CoV-2 Spike
28. Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments
29. Abstract 1070: AUTO7: Anti-PSMA humanized CAR T-cell with improved persistence and resistance to tumor microenvironment for metastatic castration resistant prostate cancer (mCRPC)
30. Abstract 2183: Targeting TRBC1 and 2 for the treatment of T cell lymphomas
31. Generation of a Highly Sensitive CD22 CAR
32. Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile
33. Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy Targeting CD19 and CD22, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study
34. Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments.
35. Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study
36. Structure Guided Engineering of Highly Specific Chimeric Antigen Receptors for the Treatment of T Cell Lymphomas
37. Analysis of T-Cell Receptor Beta-Constant Region Expression for Rapid Assessment of T-Cell Clonality
38. Rational design of antirheumatic prodrugs specific for sites of inflammation
39. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
40. Targeting T-Cell Receptor β-Constant Domain for Immunotherapy of T-Cell Malignancies
41. Construction and Pre-Clinical Evaluation of a New Anti-CD19 Chimeric Antigen Receptor
42. AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies
43. Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation
44. A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells
45. A1.54 Development of a novel bispecific therapeutic for rheumatoid arthritis
46. Knotted Fusion Proteins Reveal Unexpected Possibilities in Protein Folding
47. Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis
48. Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt.
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