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1. Twenty-Minute No-Touch Period Before Controlled DCD Heart Retrieval: Is There Still a Chance for Successful Recovery? The Italian Experience

Author

Gerosa, G., primary, Pradegan, N., additional, Tarzia, V., additional, Lena, T., additional, Zanatta, P., additional, Galeone, A., additional, Gottin, L., additional, Onorati, F., additional, Boffini, M., additional, Zanierato, M., additional, Botta, L., additional, Martin Suarez, S., additional, Feccia, M., additional, Lilla Della Monica, P., additional, Oliveti, A., additional, Pacini, D., additional, Rinaldi, M., additional, Luciani, G.B., additional, and Cardillo, M., additional

Published
2024
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4. Malperfusion Syndrome in Patients with Acute Type A Aortic Dissection: Incidence and Mortality Rates after Surgical Repair.

Author

Dell, A. A., Wisniewski, K., Onorati, F., Demal, T.J., Peterss, S., Fiore, A., Perrotti, A., Nappi, F., Pinto, A.G., Pol, M., Mazzaro, E., Vendramin, I., Ferrante, L., Quintana, E., Gerelli, S., Acharya, M., Field, M., Pettinari, M., Stefano, R., and Juvonen, T.

Subjects
AORTIC dissection, DEATH rate, DISSECTION, SYNDROMES, HOSPITAL mortality
Abstract

This article discusses the incidence and mortality rates of malperfusion syndrome in patients with acute Type A aortic dissection after surgical repair. The study, conducted across 18 European centers, included 3,902 patients. It found that 45.62% of patients presented with signs of preoperative malperfusion, with the most common type being cerebral malperfusion. The study also showed that rates of in-hospital mortality increased with the severity of malperfusion. The authors conclude that different levels of the Penn classification can be used as valid predictors of mortality. [Extracted from the article]

Published
2024
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5. Predictor Analysis for Acute Type A Aortic Dissection in Small Aortic Diameters

Author

Demal, T. J., additional, Detter, C., additional, von Kodolitsch, Y., additional, Mariscalco, G., additional, Gatti, G., additional, Peterss, S., additional, Büch, J., additional, Onorati, F., additional, Perrotti, A., additional, Fiore, A., additional, Pettinari, M., additional, Dell'aquila, A. M., additional, Pol, M., additional, Field, M., additional, Vendramin, I., additional, Rinaldi, M., additional, Lega, J. R., additional, Juvonen, T., additional, Quintana, E., additional, Pinto, A. G., additional, Nappi, F., additional, Di Perna, D., additional, Reichenspurner, H., additional, Biancari, F., additional, and Conradi, L., additional

Published
2023
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6. RF44 OUTCOME AFTER BILATERAL INTERNAL MAMMARY ARTERY GRAFTING IN HIGH- AND LOW-VOLUME HOSPITALS: AN ANALYSIS OF THE E-CABG REGISTRY

Author

Saccocci, M., Perotti, A., Reichart, D., Gatti, G., Faggian, G., Onorati, F., Feo, M. De, Chocron, S., Dalen, M., Santarpino, G., Rubino, A.S., Maselli, D., Gherli, R., Salsano, A., Nicolini, F., Zanobini, M., Bounader, K., Seccareccia, F., Rosato, S., Tauriainen, T., Mariscalco, G., Ruggieri, V.G., and Biancari, F.

Published
2018
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9. OC11 CLINICAL FRAILTY SCALE AND OUTCOME AFTER CORONARY ARTERY BYPASS GRAFTING: AN ANALYSIS OF THE E-CABG REGISTRY

Author

Saccocci, M., Reichart, D., Rosato, S., Nammas, W., Onorati, F., Dalen, M., Castro, L., Gherli, R., Gatti, G., Franzese, I., Faggian, G., De Feo, M., Khodabandeh, S., Santarpino, G., Rubino, A.S., Maselli, D., Nardella, S., Salsano, A., Nicolini, F., Zanobini, M., Bounader, K., Kinnunen, E., Tauriainen, T., Airaksinen, J., Seccareccia, F., Mariscalco, G., Ruggieri, V.G., Perrotti, A., and Biancari, F.

Published
2018
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10. OC87 VALUE OF SCREENING ASYMPTOMATIC CAROTID ARTERY STENOSIS PRIOR TO CORONARY ARTERY BYPASS GRAFTING: ANALYSIS OF THE E-CABG REGISTRY

Author

Salsano, A., Santarpino, G., Santini, F., Nicolini, F., De Feo, M., Dalén, M., Fischlein, T., Perrotti, A., Reichart, D., Gatti, G., Onorati, F., Franzese, I., Faggian, G., Bancone, C., Chocron, S., Khodabandeh, S., Rubino, A.S., Maselli, D., Nardella, S., Gherli, R., Zanobini, M., Saccocci, M., Bounader, K., Rosato, S., Tauriainen, T., Mariscalco, G., Airaksinen, J., Ruggieri, V.G., and Biancari, F.

Published
2018
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11. OC88 COMPARATIVE ANALYSIS OF PROTHROMBIN COMPLEX CONCENTRATE AND FRESH FROZEN PLASMA IN THE MANAGEMENT OF PERIOPERATIVE BLEEDING AFTER CORONARY ARTERY BYPASS GRAFTING

Author

Salsano, A., Mariscalco, G., Santini, F., Ruggieri, V.G., Perrotti, A., Chocron, S., Gherli, R., Reichart, D., Demal, T., Faggian, G., Franzese, I., Dalén, M., Santarpino, G., Fischlein, T., Rubino, A.S., Maselli, D., Nardella, S., Nicolini, F., Saccocci, M., Gatti, G., Bounader, K., Rosato, S., Kinnunen, E., De Feo, M., Tauriainen, T., Onorati, F., and Biancari, F.

Published
2018
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13. OC71 SURGICAL TREATMENT FOR ISOLATED TRICUSPID VALVE INFECTIVE ENDOCARDITIS. 25-YEAR RESULTS

Author

Di Mauro, M., Dato, G. Actis, Barili, F., Corte, A. Della, Ratta, E. Della, Cugola, D., Galletti, L., Centofanti, P., Santini, F., Salsano, A., Rinaldi, M., Mancuso, S., Cappabianca, G., Beghi, C., De Vincentiis, C., Biondi, A., Livi, U., Sponga, S., Pacini, D., Murara, G., Di Bortalomeo, R., Scrofani, R., Cagnoni, G., Antona, C., Nicolini, F., Benassi, F., De Bonis, M., Pozzoli, A., Casali, G., Scrascia, G., Bortolotti, U., Falcetta, G., Musumeci, F., Gherli, R., Vizzardi, E., Salvador, L., Piccichè, M., Paparella, D., Margari, V., Troise, G., Villa, E., Dossena, Y., Lucarelli, C., Onorati, F., Faggian, G., Mariscalco, G., Maselli, D., Foschi, M., Parolari, A., and Lorusso, R.

Published
2018
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16. COVID-19 in Heart Transplant Recipients: A Multicenter Analysis of the Northern Italian Outbreak

Author

Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, Gerosa, G, Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, Gerosa G, Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, Gerosa, G, Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, and Gerosa G

Abstract

Objectives: The aim of this study was to assess the clinical course and outcomes of all heart transplant recipients affected by coronavirus disease-2019 (COVID-19) who were followed at the leading heart transplant centers of Northern Italy. Background: The worldwide severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has created unprecedented challenges for public health, demanding exceptional efforts for the successful management and treatment of affected patients. Heart transplant patients represent a unique cohort of chronically immunosuppressed subjects in which SARS-CoV-2 may stimulate an unpredictable clinical course of infection. Methods: Since February 2020, we enrolled all 47 cases (79% male) in a first cohort of patients, with a mean age of 61.8 ± 14.5 years, who tested positive for SARS-CoV-2, out of 2,676 heart transplant recipients alive before the onset of the COVID-19 pandemic at 7 heart transplant centers in Northern Italy. Results: To date, 38 patients required hospitalization while 9 remained self-home quarantined and 14 died. Compared to the general population, prevalence (18 vs. 7 cases per 1,000) and related case fatality rate (29.7% vs. 15.4%) in heart transplant recipients were doubled. Univariable analysis showed older age (p = 0.002), diabetes mellitus (p = 0.040), extracardiac arteriopathy (p = 0.040), previous PCI (p = 0.040), CAV score (p = 0.039), lower GFR (p = 0.004), and higher NYHA functional classes (p = 0.023) were all significantly associated with in-hospital mortality. During the follow-up two patients died and a third patient has prolonged viral-shedding alternating positive and negative swabs. Since July 1st, 2020, we had 6 new patients who tested positive for SARS-CoV-2, 5 patients asymptomatic were self-quarantined, while 1 is still hospitalized for pneumonia. A standard therapy was maintained for all, except for the hospitalized patient. Conclusions: The prevalence and mortality of SARS-CoV-2 should spur cl

Published
2021

17. COVID-19 in Heart Transplant Recipients: A Multicenter Analysis of the Northern Italian Outbreak

Author

Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, Gerosa G, Bottio T., Bagozzi L., Fiocco A., Nadali M., Caraffa R., Bifulco O., Ponzoni M., Lombardi C.M., Metra M., Russo C.F., Frigerio M., Masciocco G., Potena L., Loforte A., Pacini D., Faggian G., Onorati F., Sponga S., Livi U., Iacovoni A., Terzi A., Senni M., Rinaldi M., Boffini M., Marro M., Jorgji V., Carrozzini M., Gerosa G., Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, and Gerosa, G

Subjects
Male, COVID-19 and heart transplant recipient, TAPSE, Tricuspid annular plane systolic excursion, immunosuppressive therapy, COPD, Chronic obstructive pulmonary disease, BMI, Body mass index, Comorbidity, heart transplantation, Article, COVID-19 and heart transplant recipients, Follow-Up Studie, ECLS, Extracorporeal life support, SARS-CoV-2, Severe Acute Respiratory Syndrome-Coronavirus-2, Retrospective Studie, ICU, Intensive Care Unit, ARDS, Acute respiratory distress syndrome, Humans, COVID-19, Coronavirus Disease 19, sPAP, Systolic pulmonary artery pressure, PCI, Percutaneous coronary intervention, Hospital Mortality, NYHA, New York Heart Association, Pandemics, Aged, Retrospective Studies, RT-PCR, Reverse transcriptase-polymerase chain reaction, Heart Failure, Pandemic, SARS-CoV-2, ALT, Alanine aminotransferase, COVID-19, Female, Follow-Up Studies, Italy, Middle Aged, Heart Transplantation, Transplant Recipients, CAV, Cardiac allograft vasculopathy, GFR, Glomerular filtration rate, CRP, C-reactive Protein, WBC, White blood cells, LVEF, Left ventricular ejection fraction, PCT, Procalcitonin, iLVEDV, Indexed left ventricular end-diastolic volume, AST, Aspartate aminotransferase, Human
Abstract

Aims The aim of this study was to assess the clinical course and outcomes of all heart transplant recipients affected by COVID-19 who were followed at the leading heart transplant centers of Northern Italy. Method and Results Since February 2020, we enrolled all 47 cases (79% male) in a first cohort of patients, with a mean age of 61.8 ± 14.5 years, who tested positive for SARS-CoV-2, out of 2676 heart transplant recipients alive before the onset of the COVID-19 pandemic at 7 heart transplant centers in Northern Italy. To date, 38 patients required hospitalization while 9 remained self-home quarantined and 14 died. Compared to the general population, prevalence (18 vs 7 cases per 1000) and related case fatality rate (29.7 vs 15.4%) in heart transplant recipients were doubled. Univariable analysis showed older age (p=0.002), diabetes mellitus (p=0.040), extracardiac arteriopathy (p=0.040), previous PCI (p=0.040), CAV score (p=0.039), lower GFR (p=0.004), and higher NYHA classes (p=0.023) were all significantly associated with in-hospital mortality. During the follow-up two patients died and a third patient has prolonged viral-shedding alternating positive and negative swabs. Since 1st July 2020, we had 6 new patients who tested positive for SARS-CoV-2, 5 patients asymptomatic were self-quarantined, while 1 is still hospitalized for pneumonia. A standard therapy was maintained for all, except for the hospitalized patient. Conclusion The prevalence and mortality of SARS-CoV-2 should spur clinicians to immediately refer heart transplant recipients suspected as having SARS-CoV2 infection to centers specializing in the care of this vulnerable population., Graphical abstract

Published
2021

18. Late myocardial infarction and repeat revascularization after coronary artery bypass grafting in patients with prior percutaneous coronary intervention

Author

Biancari, F. (Fausto), Salsano, A. (Antonio), Santini, F. (Francesco), De Feo, M. (Marisa), Dalén, M. (Magnus), Zhang, Q. (Qiyao), Gatti, G. (Giuseppe), Mazzaro, E. (Enzo), Franzese, I. (Ilaria), Bancone, C. (Ciro), Zanobini, M. (Marco), Tauriainen, T. (Tuomas), Mäkikallio, T. (Timo), Saccocci, M. (Matteo), Francica, A. (Alessandra), Rosato, S. (Stefano), El-Dean, Z. (Zein), Onorati, F. (Francesco), Mariscalco, G. (Giovanni), Biancari, F. (Fausto), Salsano, A. (Antonio), Santini, F. (Francesco), De Feo, M. (Marisa), Dalén, M. (Magnus), Zhang, Q. (Qiyao), Gatti, G. (Giuseppe), Mazzaro, E. (Enzo), Franzese, I. (Ilaria), Bancone, C. (Ciro), Zanobini, M. (Marco), Tauriainen, T. (Tuomas), Mäkikallio, T. (Timo), Saccocci, M. (Matteo), Francica, A. (Alessandra), Rosato, S. (Stefano), El-Dean, Z. (Zein), Onorati, F. (Francesco), and Mariscalco, G. (Giovanni)

Abstract

Objectives: The aim of the present study was to evaluate the risk of late mortality and major adverse cardiovascular and cerebral events after coronary artery bypass grafting (CABG) in patients with prior percutaneous coronary intervention (PCI). Methods: A total of 2948 patients undergoing isolated CABGs were included in a prospective multicenter registry. Outcomes were adjusted for multiple covariates in logistic regression, Cox proportional hazards analysis and competing risk analysis. Results: In all, 2619 patients fulfilled the inclusion criteria of this analysis. Of them, 2199 (79.1%) had no history of PCI and 420 (20.9%) had a prior PCI. An adjusted analysis showed that a single prior PCI and multiple prior PCIs did not increase the risk of 30-day and 5-year mortality. Patients with multiple prior PCIs had a significantly higher risk of 5-year myocardial infarction (SHR 2.566, 95%CI 1.379–4.312) and repeat revascularization (SHR 1.774, 95%CI 1.140–2.763). Similarly, 30-day and 5-year mortality were not significantly increased in patients with prior PCI treatment of single or multiple vessels. Patients with multiple vessels treated with PCI had a significantly higher risk of 5-year myocardial infarction (SHR 2.640, 95%CI 1.497–4.658), repeat revascularization (SHR 1.648, 95%CI 1.029–2.638) and stroke (SHR 2.215, 95%CI 1.056–4.646) at 5-year. The risk for repeat revascularization was also increased with a prior single vessel PCI, but not for other outcomes. Conclusions: Among patients undergoing CABGs, multiple prior PCIs seem to increase the risk of late myocardial infarction and the need for repeat revascularization, but not the risk of mortality.

Published
2022

20. Multicenter Italian Study on Radial Mechanically Assisted Circulatory Support (MIRAMACS): Ongoing Analyses

Author

Loforte, A., primary, Gliozzi, G., additional, Attisani, M., additional, Comisso, M., additional, Iacovoni, A., additional, Maiani, M., additional, Boschi, S., additional, Onorati, F., additional, Scandroglio, M., additional, Baronetto, A., additional, Terzi, A., additional, De Bonis, M., additional, Santini, F., additional, Faggian, G., additional, Livi, U., additional, Musumeci, F., additional, Rinaldi, M., additional, and Pacini, D., additional

Published
2022
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24. Surgical treatment of isolated tricuspid valve infective endocarditis: 25-year results from a multicenter registry

Author

Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., Lorusso R., Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., and Lorusso R.

Abstract

Background: To assess early and late mortality in patients with isolated acute tricuspid valve infective endocarditis (TVIE) using data from a multicenter registry. Methods: From 1983 to 2018, isolated acute TVIE was surgically treated in 157 (3.8%) patients [mean age 47 ± 16 years (range 15–86 years), 25% females]. Of these, 142 (90%) had native tricuspid regurgitation, 7 (5%) native tricuspid valve (TV) steno-regurgitation, and 8 (5%) prosthetic TVIE. Intravenous drug use (IVDU) was recorded in 38% of patients, infection involved cardiac implantable electronic device leads in 21%, and vascular catheters for dialysis in 1%; in the remaining cases, the cause was unknown. The primary endpoint was in-hospital outcome, long-term freedom from recurrence and overall survival. Results: Overall, 77 (49%) patients underwent TV repair, 72 (46%) TV replacement, and 8 (5%) prosthetic TV replacement. Early mortality was 11% (n = 17). Expected early mortality according to EndoSCORE was 12%, with age (odds ratio 1.06) and redo (odds ratio 6.64) as risk factors. Late deaths occurred in 31 patients and TVIE recurrences in 4. Survival rates at 10, 20, and 25 years were 66%, 60%, and 44%, respectively. Risk factors were age [hazard ratio (HR) 1.06], mycotic TVIE (HR 4.2), IVDU (HR 4.90), infected prosthesis replacement (HR 4.4), and presence of cardiac implantable electronic device leads (HR 3.0). No significant difference was found in valve repair vs. replacement and in IVDUs vs. non-IVDUs. Conclusions: Patients with isolated acute TVIE undergoing surgical treatment show acceptable early and late outcomes. TVIE recurrence was low, and repair of the affected valve does not seem to confer any advantage either at early or long term up to 25 years.

Published
2019

26. Correction to: European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria (Journal of Cardiothoracic Surgery, (2021), 16, 1, (171), 10.1186/s13019-021-01536-5)

Author

Biancari, F., Mariscalco, G., Yusuff, H., Tsang, G., Luthra, S., Onorati, F., Francica, A., Rossetti, C., Perrotti, A., Chocron, S., Fiore, A., Folliguet, T., Pettinari, M., Dell'Aquila, A. M., Demal, T., Conradi, L., Detter, C., Pol, M., Ivak, P., Schlosser, F., Forlani, S., Chetty, G., Harky, A., Kuduvalli, M., Field, M., Vendramin, I., Livi, U., Rinaldi, M., Ferrante, L., Etz, C., Noack, T., Mastrobuoni, S., De Kerchove, L., Jormalainen, M., Laga, S., Meuris, B., Schepens, M., Dean, Z. E., Vento, A., Raivio, P., Borger, M., and Juvonen, T.

Published
2021

27. European registry of type A aortic dissection (ERTAAD):rationale, design and definition criteria

Author

Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), Juvonen, T. (Tatu), Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), and Juvonen, T. (Tatu)

Abstract

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient’s conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. Methods: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient’s comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit. Discussion: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD. Trial registration: ClinicalTrials.gov Identifier: NCT04831073.

Published
2021

30. Multicenter Italian Study on Radial Mechanically Assisted Circulatory Support (MIRAMACS): Preliminary Results

Author

Loforte, A., primary, Gliozzi, G., additional, Attisani, M., additional, Montalto, A., additional, Iacovoni, A., additional, Onorati, F., additional, Maiani, M., additional, Scandroglio, M., additional, Terzi, A., additional, De Bonis, M., additional, Faggian, G., additional, Livi, U., additional, Musumeci, F., additional, Rinaldi, M., additional, and Pacini, D., additional

Published
2021
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31. Corrigendum to “A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE”. [Int. J. Cardiol. 241 (Aug 15 2017) 97–102](S0167527317309877)(10.1016/j.ijcard.2017.03.148)

Author

Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., Nappi G., Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., and Nappi G.

Abstract

The authors regret that the first name and last name of the author Sandro Sponga was published incorrectly in the original version and this has now been corrected.

Published
2018

33. Impact of Aortic Manipulation on High Perioperative Cerebral Stroke Risk Undergoing Coronary Artery Bypass Grafting: Results from the E-CABG (European Multicenter Study on Coronary Artery Bypass Grafting)

Author

Naito, S., additional, Demal, T. J., additional, Schneeberger, Y., additional, Reichenspurner, H., additional, Gatti, G., additional, Onorati, F., additional, Mariscalco, G., additional, Santini, F., additional, Sill, B., additional, and Biancari, F., additional

Published
2021
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34. On-Pump versus Off-Pump Coronary Bypass Grafting in Patients with Non–Dialysis-Dependent Renal Impairment

Author

Hua, X., additional, Demal, T. J., additional, Reiter, B., additional, Dalén, M., additional, Ruggieri, V. G., additional, Gatti, G., additional, Onorati, F., additional, Rubino, A. S., additional, Maselli, D., additional, Gherli, R., additional, Salsano, A., additional, Saccocci, M., additional, Santarpino, G., additional, Nicolini, F., additional, De Feo, M., additional, Perrotti, A., additional, Mariscalco, G., additional, Reichenspurner, H., additional, and Biancari, F., additional

Published
2021
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41. Infectious complications in patients receiving ticagrelor or clopidogrel before coronary artery bypass grafting

Author

Dalén, M., primary, Biancari, F., additional, Perrotti, A., additional, Mariscalco, G., additional, Onorati, F., additional, Faggian, G., additional, Franzese, I., additional, Salsano, A., additional, Santini, F., additional, Ruggieri, V.G., additional, Maselli, D., additional, Nardella, S., additional, Santarpino, G., additional, Fischlein, T., additional, Saccocci, M., additional, Zanobini, M., additional, Musumeci, F., additional, Gherli, R., additional, Rubino, A.S., additional, De Feo, M., additional, Bancone, C., additional, Nicolini, F., additional, Kinnunen, E.-M., additional, Tauriainen, T., additional, Reichart, D., additional, Demal, T., additional, Gatti, G., additional, Khodabandeh, S., additional, and Holm, M., additional

Published
2020
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44. A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE

Author

Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sandro, S, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sandro S., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., Nappi G., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sandro, S, Pacini, D, Di Bartolomeo, R, De Martino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sandro S., Pacini D., Di Bartolomeo R., De Martino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., and Nappi G.

Abstract

Background The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). Methods From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or prosthesis valve endocarditis (PVE) were operated on in 26 Italian Cardiac Surgery Centers. The relationship between early mortality and covariates was evaluated with logistic mixed effect models. Fixed effects are parameters associated with the entire population or with certain repeatable levels of experimental factors, while random effects are associated with individual experimental units (centers). Results Early mortality was 11.0% (298/2715); At mixed effect logistic regression the following variables were found associated with early mortality: age class, female gender, LVEF, preoperative shock, COPD, creatinine value above 2 mg/dl, presence of abscess, number of treated valve/prosthesis (with respect to one treated valve/prosthesis) and the isolation of Staphylococcus aureus, Fungus spp., Pseudomonas Aeruginosa and other micro-organisms, while Streptococcus spp., Enterococcus spp. and other Staphylococci did not affect early mortality, as well as no micro-organisms isolation. LVEF was found linearly associated with outcomes while non-linear association between mortality and age was tested and the best model was found with a categorization into four classes (AUC = 0.851). Conclusions The following study provides a logistic risk model to predict early mortality in patients with heart valve or prosthesis infective endocarditis undergoing surgical treatment, called “The EndoSCORE”.

Published
2017

50. Impact of preoperative thrombocytopenia on the outcome after coronary artery bypass grafting

Author

Nammas, W. (Wail), Dalén, M. (Magnus), Rosato, S. (Stefano), Gherli, R. (Riccardo), Reichart, D. (Daniel), Gatti, G. (Giuseppe), Onorati, F. (Francesco), Faggian, G. (Giuseppe), De Feo, M. (Marisa), Bancone, C. (Ciro), Chocron, S. (Sidney), Khodabandeh, S. (Sorosh), Santarpino, G. (Giuseppe), Rubino, A. S. (Antonino S.), Maselli, D. (Daniele), Nardella, S. (Saverio), Salsano, A. (Antonio), Gherli, T. (Tiziano), Nicolini, F. (Francesco), Zanobini, M. (Marco), Saccocci, M. (Matteo), Bounader, K. (Karl), D’Errigo, P. (Paola), Kiviniemi, T. (Tuomas), Kinnunen, E.-M. (Eeva-Maija), Perrotti, A. (Andrea), Airaksinen, J. (Juhani), Mariscalco, G. (Giovanni), Ruggieri, V. G. (Vito G.), Biancari, F. (Fausto), Nammas, W. (Wail), Dalén, M. (Magnus), Rosato, S. (Stefano), Gherli, R. (Riccardo), Reichart, D. (Daniel), Gatti, G. (Giuseppe), Onorati, F. (Francesco), Faggian, G. (Giuseppe), De Feo, M. (Marisa), Bancone, C. (Ciro), Chocron, S. (Sidney), Khodabandeh, S. (Sorosh), Santarpino, G. (Giuseppe), Rubino, A. S. (Antonino S.), Maselli, D. (Daniele), Nardella, S. (Saverio), Salsano, A. (Antonio), Gherli, T. (Tiziano), Nicolini, F. (Francesco), Zanobini, M. (Marco), Saccocci, M. (Matteo), Bounader, K. (Karl), D’Errigo, P. (Paola), Kiviniemi, T. (Tuomas), Kinnunen, E.-M. (Eeva-Maija), Perrotti, A. (Andrea), Airaksinen, J. (Juhani), Mariscalco, G. (Giovanni), Ruggieri, V. G. (Vito G.), and Biancari, F. (Fausto)

Abstract

The impact of thrombocytopenia on postoperative bleeding and other major adverse events after cardiac surgery is unclear. This issue was investigated in a series of patients who underwent isolated coronary artery bypass grafting (CABG) from the prospective, multicenter E-CABG registry. Preoperative thrombocytopenia was defined as preoperative platelet count <150 × 10⁹/L and it was considered moderate-severe when preoperative platelet count was <100 × 10⁹/L. Multilevel mixed-effects regression analysis was performed to adjust the effect of thrombocytopenia on outcomes for baseline and operative covariates as well as for interinstitutional differences in patient-blood management. Among 7189 patients included in this analysis, 599 (8.3%) had preoperative thrombocytopenia. Patient with preoperative thrombocytopenia had an increased chest drainage output at 12 h (mean, 519 vs. 456 mL, adjusted coeff. 39, 95%CI 18–60) and rates of severe-massive bleeding (Universal Definition of Perioperative Bleeding (UDPB) severity grades 3–4: 12.7% vs. 8.1%, adjusted OR 1.47, 95%CI 1.11–1.93; E-CABG bleeding severity grades 2–3: 10.4% vs. 6.1%, adjusted OR 1.78, 95%CI 1.30–2.43). Thrombocytopenia was associated with an increased risk of hospital/30-day death (3.2% vs. 1.9%, adjusted OR 2.02, 95%CI 1.20–3.42), 1-year death (5.7% vs. 3.4%, adjusted HR 1.68, 95%CI 1.16–2.44), deep sternal wound infection (3.5% vs. 2.4%, adjusted OR 1.65, 95%CI 1.02–2.66), acute kidney injury (28.1% vs. 22.2%, OR 1.45, 1.18–1.78), and prolonged stay in the intensive care unit (mean, 3.6 vs 2.8 days, adjusted coeff. 0.74, 95%CI 0.40–1.09). Similar results were observed in a subset of patients with moderate-severe thrombocytopenia (51 patients, 0.7%). In particular, these patients had a markedly higher rate of acute kidney injury (40%, adjusted OR, 1.94, 95%CI 1.05–3.57), resternotomy for bleeding (7.8%, adjusted OR 3.49, 95%CI 1.20–10.21), and severe-massive bleeding (UDPB severity grades 3–4

Published
2019

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