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21 results on '"Onomura, Mai"'

2. Supplementary Table from Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study

Author

Zembutsu, Hitoshi, primary, Nakamura, Seigo, primary, Akashi-Tanaka, Sadako, primary, Kuwayama, Takashi, primary, Watanabe, Chie, primary, Takamaru, Tomoko, primary, Takei, Hiroyuki, primary, Ishikawa, Takashi, primary, Miyahara, Kana, primary, Matsumoto, Hiroshi, primary, Hasegawa, Yoshie, primary, Kutomi, Goro, primary, Shima, Hiroaki, primary, Satomi, Fukino, primary, Okazaki, Minoru, primary, Zaha, Hisamitsu, primary, Onomura, Mai, primary, Matsukata, Ayami, primary, Sagara, Yasuaki, primary, Baba, Shinichi, primary, Yamada, Akimitsu, primary, Shimada, Kazuhiro, primary, Shimizu, Daisuke, primary, Tsugawa, Koichiro, primary, Shimo, Arata, primary, Tan, Ern Yu, primary, Hartman, Mikael, primary, Chan, Ching-Wan, primary, Lee, Soo Chin, primary, and Nakamura, Yusuke, primary

Published
2023
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3. Supplementary Figures from Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study

Author

Zembutsu, Hitoshi, primary, Nakamura, Seigo, primary, Akashi-Tanaka, Sadako, primary, Kuwayama, Takashi, primary, Watanabe, Chie, primary, Takamaru, Tomoko, primary, Takei, Hiroyuki, primary, Ishikawa, Takashi, primary, Miyahara, Kana, primary, Matsumoto, Hiroshi, primary, Hasegawa, Yoshie, primary, Kutomi, Goro, primary, Shima, Hiroaki, primary, Satomi, Fukino, primary, Okazaki, Minoru, primary, Zaha, Hisamitsu, primary, Onomura, Mai, primary, Matsukata, Ayami, primary, Sagara, Yasuaki, primary, Baba, Shinichi, primary, Yamada, Akimitsu, primary, Shimada, Kazuhiro, primary, Shimizu, Daisuke, primary, Tsugawa, Koichiro, primary, Shimo, Arata, primary, Tan, Ern Yu, primary, Hartman, Mikael, primary, Chan, Ching-Wan, primary, Lee, Soo Chin, primary, and Nakamura, Yusuke, primary

Published
2023
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7. The Challenge to Reduce Breast Cancer Mortality in Okinawa: Consensus of the First Okinawa Breast Oncology Meeting

Author

Tamaki, Kentaro, Tamaki, Nobumitsu, Kamada, Yoshihiko, Uehara, Kano, Zaha, Hisamitsu, Onomura, Mai, Gushimiyagi, Masanori, Kurashita, Kaname, Miyazato, Keiko, Tengan, Hiromu, Miyara, Kyuichiro, Ishida, Takanori, Tamaki, Kentaro, Tamaki, Nobumitsu, Kamada, Yoshihiko, Uehara, Kanou, Zaha, Hisamitsu, Onomura, Mai, Gushimiyagi, Masanori, Ueda, Makoto, Kurashita, Kaname, Miyazato, Keiko, Tengan, Hiromu, Miyara, Kyuichiro, Miyaguni, Takao, Nagamine, Shinji, Miyagi, Jun, Nomura, Hironori, Sunagawa, Kazuya, Higa, Junko, Sato, Chiho, and Ishida, Takanori

Published
2013
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10. A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study

Author

Onishi, Hiroshi, primary, Udagawa, Chihiro, additional, Kubo, Michiaki, additional, Nakamura, Seigo, additional, Akashi-Tanaka, Sadako, additional, Kuwayama, Takashi, additional, Watanabe, Chie, additional, Takamaru, Tomoko, additional, Takei, Hiroyuki, additional, Ishikawa, Takashi, additional, Miyahara, Kana, additional, Matsumoto, Hiroshi, additional, Hasegawa, Yoshie, additional, Momozawa, Yukihide, additional, Low, Siew-Kee, additional, Kutomi, Goro, additional, Shima, Hiroaki, additional, Satomi, Fukino, additional, Okazaki, Minoru, additional, Zaha, Hisamitsu, additional, Onomura, Mai, additional, Matsukata, Ayami, additional, Sagara, Yasuaki, additional, Baba, Shinichi, additional, Yamada, Akimitsu, additional, Shimada, Kazuhiro, additional, Shimizu, Daisuke, additional, Tsugawa, Koichiro, additional, Shimo, Arata, additional, Hartman, Mikael, additional, Chan, Ching-Wan, additional, Lee, Soo Chin, additional, Endo, Itaru, additional, and Zembutsu, Hitoshi, additional

Published
2018
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11. Significant Effect of Polymorphisms inCYP2D6on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study

Author

Zembutsu, Hitoshi, primary, Nakamura, Seigo, additional, Akashi-Tanaka, Sadako, additional, Kuwayama, Takashi, additional, Watanabe, Chie, additional, Takamaru, Tomoko, additional, Takei, Hiroyuki, additional, Ishikawa, Takashi, additional, Miyahara, Kana, additional, Matsumoto, Hiroshi, additional, Hasegawa, Yoshie, additional, Kutomi, Goro, additional, Shima, Hiroaki, additional, Satomi, Fukino, additional, Okazaki, Minoru, additional, Zaha, Hisamitsu, additional, Onomura, Mai, additional, Matsukata, Ayami, additional, Sagara, Yasuaki, additional, Baba, Shinichi, additional, Yamada, Akimitsu, additional, Shimada, Kazuhiro, additional, Shimizu, Daisuke, additional, Tsugawa, Koichiro, additional, Shimo, Arata, additional, Tan, Ern Yu, additional, Hartman, Mikael, additional, Chan, Ching-Wan, additional, Lee, Soo Chin, additional, and Nakamura, Yusuke, additional

Published
2017
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13. Abstract 2031: Association between CYP2D6 genotype and response to tamoxifen in a prospective multicenter study in Japan

Author

Zembutsu, Hitoshi, primary, Nakamura, Seigo, additional, Akashi-Tanaka, Sadako, additional, Kuwayama, Takashi, additional, Watanabe, Chie, additional, Takamaru, Tomoko, additional, Takei, Hiroyuki, additional, Miyahara, Kana, additional, Matsumoto, Hiroshi, additional, Hasegawa, Yoshie, additional, Kutomi, Goro, additional, Shima, Hiroaki, additional, Satomi, Fukino, additional, Maeda, Hideki, additional, Okazaki, Minoru, additional, Zaha, Hisamitsu, additional, Onomura, Mai, additional, Matsukata, Ayami, additional, Sagara, Yasuaki, additional, Baba, Shinichi, additional, Yamada, Akimitsu, additional, Shimada, Kazuhiro, additional, Shimizu, Daisuke, additional, Tsugawa, Koichiro, additional, Shimo, Arata, additional, Yu, Tan Ern, additional, Hartman, Mikael, additional, Wang, Chan Ching, additional, Lee, Soo Chin, additional, and Nakamura, Yusuke, additional

Published
2016
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20. Significant Effect of Polymorphisms in CYP2D6 on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study.

Author

Zembutsu H, Nakamura S, Akashi-Tanaka S, Kuwayama T, Watanabe C, Takamaru T, Takei H, Ishikawa T, Miyahara K, Matsumoto H, Hasegawa Y, Kutomi G, Shima H, Satomi F, Okazaki M, Zaha H, Onomura M, Matsukata A, Sagara Y, Baba S, Yamada A, Shimada K, Shimizu D, Tsugawa K, Shimo A, Tan EY, Hartman M, Chan CW, Lee SC, and Nakamura Y

Subjects
Adult, Aged, Aged, 80 and over, Female, Genotype, Humans, Ki-67 Antigen analysis, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, Treatment Outcome, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Cytochrome P-450 CYP2D6 genetics, Tamoxifen therapeutic use
Abstract

Purpose: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, "endoxifen." There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. Hence, we performed a prospective multicenter study to evaluate the clinical effect of CYP2D6 genotype on tamoxifen therapy. Experimental Design: We enrolled 279 patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative, invasive breast cancer receiving preoperative tamoxifen monotherapy for 14 to 28 days. Ki-67 response in breast cancer tissues after tamoxifen therapy was used as a surrogate marker for response to tamoxifen. We prospectively investigated the effects of allelic variants of CYP2D6 on Ki-67 response, pathological response, and hot flushes. Results: Ki-67 labeling index in breast cancer tissues significantly decreased after preoperative tamoxifen monotherapy ( P = 0.0000000000000013). Moreover, proportion and Allred scores of estrogen receptor-positive cells in breast cancer tissues were significantly associated with Ki-67 response ( P = 0.0076 and 0.0023, respectively). Although CYP2D6 variants were not associated with pathologic response nor hot flushes, they showed significant association with Ki-67 response after preoperative tamoxifen therapy ( P = 0.018; between two groups, one with at least one wild-type allele and the other without a wild-type allele). Conclusions: This is the first prospective study evaluating the relationship between CYP2D6 variants and Ki-67 response after tamoxifen therapy. Our results suggest that genetic variation in CYP2D6 is a key predictor for the response to tamoxifen in patients with breast cancer. Clin Cancer Res; 23(8); 2019-26. ©2016 AACR ., (©2016 American Association for Cancer Research.)

Published
2017
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21. Can we improve breast cancer mortality in Okinawa? Consensus of the 7th Okinawa Breast Oncology Meeting.

Author

Tamaki K, Tamaki N, Kamada Y, Uehara K, Zaha H, Onomura M, Ueda M, Kurashita K, Miyazato K, Higa J, Miyara K, Shiraishi M, Murayama S, and Ishida T

Subjects
Breast Neoplasms diagnosis, Breast Neoplasms therapy, Early Detection of Cancer, Female, Humans, Japan epidemiology, Life Style, Breast Neoplasms mortality
Abstract

The rate of breast cancer mortality in Okinawa has gradually been increasing up to 2010. Now Okinawa has the second worst mortality rate in Japan, in part due to the enormous dietary changes resulting from the post-World War II US military occupation, high incidence of obesity, high non-optimal treatment rate, and low breast-cancer screening rate. To reduce breast cancer mortality in Okinawa, we established the Okinawa Breast Oncology Meeting (OBOM) in 2012. At the 7th OBOM held on January 10th, 2014, we discussed the breast cancer mortality in Okinawa focusing on lifestyle, breast cancer screening and optimal treatments. The Okinawan women who were overweight and/or obese during premenopausal and postmenopausal ages had a statistically significant higher risk of breast cancer development compared to those with non-overweight and/or obese women. The traditional diet of Okinawa consists of foods low in calories but rich in nutritional value. Therefore, we recommend Okinawan people not to forget the Okinawan traditional lifestyle, and to reduce their bodyweight to prevent breast cancer. One of the main goals of the OBOM is to raise breast cancer screening attendance rates to 50% (29.2% in 2010). We should standardize the quality control for breast cancer screening in Okinawa. It is important to continue enlightening the Okinawan population to receive optimal treatment. In addition, we are striving to establish systematic medical cooperation between the hospitals specializing in breast cancer treatment with rural hospitals. The OBOM group endeavors to contribute to the improvement of breast cancer mortality in Okinawa.

Published
2015
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