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1. Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

Author

Onodera H, Urayama T, Hirota K, Maeda K, Kubota-Koketsu R, Takahashi K, Hagiwara K, Okuno Y, Ikuta K, and Yunoki M

Subjects
IVIG, influenza, seasonal, neutralization, vaccine, Medicine (General), R5-920
Abstract

Hiroyuki Onodera,1 Takeru Urayama,2 Kazue Hirota,3 Kazuhiro Maeda,3 Ritsuko Kubota-Koketsu,3,4 Kazuo Takahashi,5 Katsuro Hagiwara,6 Yoshinobu Okuno,3 Kazuyoshi Ikuta,3,4 Mikihiro Yunoki,2,4,6 1Medical Information Department, 2Research and Development Division, Japan Blood Products Organization, Tokyo, 3Research and Development Division, The Research Foundation for Microbial Diseases of Osaka University, Kagawa, 4Former Department of Virology, Research Institute for Microbial Diseases, Osaka University, 5Virology Division, Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, 6Pathogenic Risk Evaluation, Graduate School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan Abstract: Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time. Keywords: IVIG, influenza, seasonal, neutralization, vaccine

Published
2017

4. Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the 'D-shuttle' project --

Author

Adachi, N., Adamovitch, V., Adjovi, Y., Aida, K., Akamatsu, H., Akiyama, S., Akli, A., Ando, A., Andrault, T., Antonietti, H., Anzai, S., Arkoun, G., Avenoso, C., Ayrault, D., Banasiewicz, M., Banaśkiewicz, M., Bernandini, L., Bernard, E., Berthet, E., Blanchard, M., Boreyko, D., Boros, K., Charron, S., Cornette, P., Czerkas, K., Dameron, M., Date, I., De Pontbriand, M., Demangeau, F., Dobaczewski, Ł., Dobrzyński, L., Ducouret, A., Dziedzic, M., Ecalle, A., Edon, V., Endo, K., Endo, T., Endo, Y., Etryk, D., Fabiszewska, M., Fang, S., Fauchier, D., Felici, F., Fujiwara, Y., Gardais, C., Gaul, W., Guérin, L., Hakoda, R., Hamamatsu, I., Handa, K., Haneda, H., Hara, T., Hashimoto, M., Hashimoto, T., Hashimoto, K., Hata, D., Hattori, M., Hayano, R., Hayashi, R., Higasi, H., Hiruta, M., Honda, A., Horikawa, Y., Horiuchi, H., Hozumi, Y., Ide, M., Ihara, S., Ikoma, T., Inohara, Y., Itazu, M., Ito, A., Janvrin, J., Jout, I., Kanda, H., Kanemori, G., Kanno, M., Kanomata, N., Kato, T., Kato, S., Katsu, J., Kawasaki, Y., Kikuchi, K., Kilian, P., Kimura, N., Kiya, M., Klepuszewski, M., Kluchnikov, E., Kodama, Y., Kokubun, R., Konishi, F., Konno, A., Kontsevoy, V., Koori, A., Koutaka, A., Kowol, A., Koyama, Y., Kozioł, M., Kozue, M., Kravtchenko, O., Kruczała, W., Kudła, M., Kudo, H., Kumagai, R., Kurogome, K., Kurosu, A., Kuse, M., Lacombe, A., Lefaillet, E., Magara, M., Malinowska, J., Malinowski, M., Maroselli, V., Masui, Y., Matsukawa, K., Matsuya, K., Matusik, B., Maulny, M., Mazur, P., Miyake, C., Miyamoto, Y., Miyata, K., Miyazaki, M., Molęda, M., Morioka, T., Morita, E., Muto, K., Nadamoto, H., Nadzikiewicz, M., Nagashima, K., Nakade, M., Nakayama, C., Nakazawa, H., Nihei, Y., Nikul, R., Niwa, S., Niwa, O., Nogi, M., Nomura, K., Ogata, D., Ohguchi, H., Ohno, J., Okabe, M., Okada, M., Okada, Y., Omi, N., Onodera, H., Onodera, K., Ooki, S., Oonishi, K., Oonuma, H., Ooshima, H., Oouchi, H., Orsucci, M., Paoli, M., Penaud, M., Perdrisot, C., Petit, M., Piskowski, A., Płocharski, A., Polis, A., Polti, L., Potsepnia, T., Przybylski, D., Pytel, M., Quillet, W., Remy, A., Robert, C., Sadowski, M., Saito, M., Sakuma, D., Sano, K., Sasaki, Y., Sato, N., Schneider, T., Schneider, C., Schwartzman, K., Selivanov, E., Sezaki, M., Shiroishi, K., Shustava, I., Śniecińska, A., Stalchenko, E., Staroń, A., Stromboni, M., Studzińska, W., Sugisaki, H., Sukegawa, T., Sumida, M., Suzuki, Y., Suzuki, K., Suzuki, R., Suzuki, H., Świderski, W., Szudejko, M., Szymaszek, M., Tada, J., Taguchi, H., Takahashi, K., Tanaka, D., Tanaka, G., Tanaka, S., Tanino, K., Tazbir, K., Tcesnokova, N., Tgawa, N., Toda, N., Tsuchiya, H., Tsukamoto, H., Tsushima, T., Tsutsumi, K., Umemura, H., Uno, M., Usui, A., Utsumi, H., Vaucelle, M., Wada, Y., Watanabe, K., Watanabe, S., Watase, K., Witkowski, M., Yamaki, T., Yamamoto, J., Yamamoto, T., Yamashita, M., Yanai, M., Yasuda, K., Yoshida, Y., Yoshida, A., Yoshimura, K., Żmijewska, M., and Zuclarelli, E.

Subjects
Physics - Medical Physics
Abstract

Twelve high schools in Japan (of which six are in Fukushima Prefecture), four in France, eight in Poland and two in Belarus cooperated in the measurement and comparison of individual external doses in 2014. In total 216 high-school students and teachers participated in the study. Each participant wore an electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of his/her whereabouts and activities. The distributions of annual external doses estimated for each region overlap with each other, demonstrating that the personal external individual doses in locations where residence is currently allowed in Fukushima Prefecture and in Belarus are well within the range of estimated annual doses due to the background radiation level of other regions/countries.

Published
2015
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6. Atomic Switch FPGA: Application for IoT Sensing Systems in Space

Author

Hihara, H., primary, Iwasaki, A., additional, Hashimoto, M., additional, Ochi, H., additional, Mitsuyama, Y., additional, Onodera, H., additional, Kanbara, H., additional, Wakabayashi, K., additional, Sugibayashi, T., additional, Takenaka, T., additional, Hada, H., additional, Tada, M., additional, Miyamura, M., additional, and Sakamoto, T., additional

Published
2020
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7. Theoretical study of angle-resolved two-photon photoemission in two-dimensional insulating cuprates

Author

Onodera, H., Tohyama, T., Tsutsui, K., and Maekawa, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We propose angle-resolved two-photon photoemission spectroscopy (AR-2PPES) as a technique to detect the location of the bottom of the upper Hubbard band (UHB) in two-dimensional insulating cuprates. The AR-2PPES spectra are numerically calculated for small Hubbard clusters. When the pump photon excites an electron from the lower Hubbard band, the bottom of the UHB is less clear, but when an electron in the nonbonding oxygen band is excited, the bottom of the UHB can be identified clearly, accompanied with additional spectra originated from the spin-wave excitation at half filling., Comment: 5 pages, 4 figures

Published
2005
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9. Temperature and Dimensionality Dependences of Optical Absorption Spectra in Mott Insulators

Author

Onodera, H., Tohyama, T., and Maekawa, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the temperature dependence of optical absorption spectra of one-dimensional (1D) and two-dimensional (2D) Mott insulators by using an effective model in the strong-coupling limit of a half-filed Hubbard model. In the numerically exact diagonalization calculations on finite-size clusters, we find that in 1D the energy position of the absorption edge is almost independent of temperature, while in 2D the edge position shifts to lower energy with increasing temperature. The different temperature dependence between 1D and 2D is attributed to the difference of the coupling of the charge and spin degrees of freedom. The implications of the results on experiments are discussed in terms of the dimensionality dependence., Comment: 5 pages, 4 figures

Published
2003
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10. Resonant Two-Magnon Raman Scattering and Photoexcited States in Two-Dimensional Mott Insulators

Author

Tohyama, T., Onodera, H., Tsutsui, K., and Maekawa, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We investigate the resonant two-magnon Raman scattering in two-dimensional (2D) Mott insulators by using a half-filled 2D Hubbard model in the strong coupling limit. By performing numerical diagonalization calculations for small clusters, we find that the Raman intensity is enhanced when the incoming photon energy is not near the optical absorption edge but well above it, being consistent with experimental data. The absence of resonance near the gap edge is associated with the presence of background spins, while photoexcited states for resonance are found to be characterized by the charge degree of freedom. The resonance mechanism is different from those proposed previously., Comment: REVTeX4, 4 pages, 3 figures, to be published in Phys. Rev. Lett

Published
2002
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43. Lattice-dictated conformers in bis(pyrazolyl)pyridine-based iron(II) complexes: Mossbauer, NMR, and magnetic studies

Author

Manikandan, P., Padmakumar, K., Thomas, K. R. Justin, Varghese, B., Onodera, H., and Manoharan, P. T.

Subjects
Chemistry, Inorganic -- Research, Pyridine -- Physiological aspects, Iron -- Physiological aspects, Coordination compounds -- Physiological aspects, Mossbauer effect -- Analysis, Chemistry
Abstract

Research has been conducted on the iron(II) complexes. The development of these complexes with the FeN (sub)6 chromophore of the same ligand and differing counterions is reported and the results of the complexes' crystal and molecular structure analysis are reported.

Published
2001

44. Microstructure and magnetic properties of Co-A1-O granular thin films

Author

Ohnuma, M., Hono, K., Onodera, H., Ohnuma, S., Fujimori, H., and Pedersen, J.S.

Subjects
Magnetic materials -- Research, Thin films -- Research, Physics
Abstract

The microstructural properties of Co-A1-O granular thin films were characterized using high resolution electron microscopy and small angle-x-ray scattering.

Published
2000

45. Elastic properties of filled-Skutterudite compounds probed by Mössbauer nuclei

Author

Tsutsui, S., primary, Umemura, J., additional, Kobayashi, H., additional, Tazaki, T., additional, Nasu, S., additional, Kobayashi, Y., additional, Yoda, Y., additional, Onodera, H., additional, Sugawara, H., additional, Matsuda, T. D., additional, Kikuchi, D., additional, Sato, H., additional, Sekine, C., additional, and Shirotani, I., additional

Published
2006
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