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25. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.

Author

Kanzaki, Noriyuki, Ono, Yoshiko, Shibata, Hiroshi, Moritani, Toshio, Kanzaki, Noriyuki, Ono, Yoshiko, Shibata, Hiroshi, and Moritani, Toshio

Abstract

[Background]: The aim of this study was to investigate the ability of a glucosamine-containing supplement to improve locomotor functions in subjects with knee pain. [Methods]: A randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted for 16 weeks in 100 Japanese subjects (age, 51.8±0.8 years) with knee pain. Subjects were randomly assigned to one of the two supplements containing 1) 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, and 5 µg of vitamin D per day (GCQID group, n=50) or 2) a placebo (placebo group, n=50). Japanese Knee Osteoarthritis Measure, visual analog scale score, normal walking speed, and knee-extensor strength were measured to evaluate the effects of the supplement on knee-joint functions and locomotor functions. [Results]: In subjects eligible for efficacy assessment, there was no significant group × time interaction, and there were improvements in knee-joint functions and locomotor functions in both groups, but there was no significant difference between the groups. In subjects with mild-to-severe knee pain at baseline, knee-extensor strength at week 8 (104.6±5.0% body weight vs 92.3±5.5% body weight, P=0.030) and the change in normal walking speed at week 16 (0.11±0.03 m/s vs 0.05±0.02 m/s, P=0.038) were significantly greater in the GCQID group than in the placebo group. Further subgroup analysis based on Kellgren–Lawrence (K–L) grade showed that normal walking speed at week 16 (1.36±0.05 m/s vs 1.21±0.02 m/s, P<0.05) was significantly greater in the GCQID group than in the placebo group in subjects with K–L grade I. No adverse effect of treatment was identified in the safety assessment. [Conclusion]: In subjects with knee pain, GCQID supplementation was effective for relieving knee pain and improving locomotor functions.

Published
2015

26. Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes

Author

1000060722329, Takada, Shingo, 1000060399871, Kinugawa, Shintaro, 1000080552869, Matsushima, Shouji, Takemoto, Daisuke, 1000060782505, Furihata, Takaaki, Mizushima, Wataru, 1000040706553, Fukushima, Arata, 1000090374321, Yokota, Takashi, Ono, Yoshiko, Shibata, Hiroshi, 1000080382539, Okita, Koichi, 1000070264017, Tsutsui, Hiroyuki, 1000060722329, Takada, Shingo, 1000060399871, Kinugawa, Shintaro, 1000080552869, Matsushima, Shouji, Takemoto, Daisuke, 1000060782505, Furihata, Takaaki, Mizushima, Wataru, 1000040706553, Fukushima, Arata, 1000090374321, Yokota, Takashi, Ono, Yoshiko, Shibata, Hiroshi, 1000080382539, Okita, Koichi, 1000070264017, and Tsutsui, Hiroyuki

Abstract

We previously reported that exercise capacity and skeletal muscle mitochondrial function in diabetic mice were impaired, in association with the activation of NAD(P)H oxidase. It has been reported that sesamin inhibits NAD(P)H oxidase‐induced superoxide production. Therefore, we examined whether the antioxidant sesamin could prevent a decline in exercise capacity in mice with high‐fat diet (HFD)‐induced diabetes. C57BL/6J mice were fed a normal diet (ND) or HFD, then treated or not with sesamin (0.2%) to yield the following four groups: ND, ND+Sesamin, HFD and HFD+Sesamin (n = 10 each). After 8 weeks, body weight, fat weight, blood glucose, insulin, triglyceride, total cholesterol and fatty acid were significantly increased in HFD compared with ND mice. Sesamin prevented the increases in blood insulin and lipid levels in HFD‐fed mice, but did not affect the plasma glucose. Exercise capacity determined by treadmill tests was significantly reduced in HFD mice, but almost completely recovered in HFD+Sesamin mice. Citrate synthase activity was significantly decreased in the skeletal muscle of HFD mice, and these decreases were also inhibited by sesamin. Superoxide anion and NAD(P)H oxidase activity were significantly increased in HFD mice compared with the ND mice and were ameliorated by sesamin. Sesamin prevented the decline in exercise capacity in HFD‐induced diabetic mice via maintenance of mitochondrial function, fat oxidation and attenuation of oxidative stress in the skeletal muscle. Our data suggest that sesamin may be useful as a novel agent for the treatment of diabetes mellitus.

Published
2015

27. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain a randomized, double-blind, placebo-controlled study

Author

Kanzaki,Noriyuki, Ono,Yoshiko, Shibata,Hiroshi, Moritani,Toshio, Kanzaki,Noriyuki, Ono,Yoshiko, Shibata,Hiroshi, and Moritani,Toshio

Abstract

Noriyuki Kanzaki,1 Yoshiko Ono,1 Hiroshi Shibata,1 Toshio Moritani2 1Institute for Health Care Science, Suntory Wellness Ltd, Seika-cho, Soraku-gun, 2Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, Japan Background: The aim of this study was to investigate the ability of a glucosamine-containing supplement to improve locomotor functions in subjects with knee pain.Methods: A randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted for 16 weeks in 100 Japanese subjects (age, 51.8±0.8 years) with knee pain. Subjects were randomly assigned to one of the two supplements containing 1) 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, and 5 µg of vitamin D per day (GCQID group, n=50) or 2) a placebo (placebo group, n=50). Japanese Knee Osteoarthritis Measure, visual analog scale score, normal walking speed, and knee-extensor strength were measured to evaluate the effects of the supplement on knee-joint functions and locomotor functions.Results: In subjects eligible for efficacy assessment, there was no significant group × time interaction, and there were improvements in knee-joint functions and locomotor functions in both groups, but there was no significant difference between the groups. In subjects with mild-to-severe knee pain at baseline, knee-extensor strength at week 8 (104.6±5.0% body weight vs 92.3±5.5% body weight, P=0.030) and the change in normal walking speed at week 16 (0.11±0.03 m/s vs 0.05±0.02 m/s, P=0.038) were significantly greater in the GCQID group than in the placebo group. Further subgroup analysis based on Kellgren–Lawrence (K–L) grade showed that normal walking speed at week 16 (1.

Published
2015

33. The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84

Author

Izumo, Takayuki, primary, Maekawa, Toshihiro, additional, Horii, Yuko, additional, Fujisaki, Yoshiyuki, additional, Ida, Masayuki, additional, Furukawa, Yuichi, additional, Ono, Yoshiko, additional, Kiso, Yoshinobu, additional, Kitagawa, Yoshinori, additional, Shibata, Hiroshi, additional, and Nagai, Katsuya, additional

Published
2013
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37. 1,5-Anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection

Author

MENG, XIAOJIE, primary, KAWAHARA, KO-ICHI, additional, MIYANOHARA, HIROAKI, additional, YOSHIMOTO, YASUSHI, additional, YOSHINAGA, KAZUHIRO, additional, NOMA, SATOSHI, additional, KIKUCHI, KIYOSHI, additional, MORIMOTO, YOKO, additional, ITO, TAKASHI, additional, OYAMA, YOKO, additional, YOSHINAGA, NARIMASA, additional, SHRESTHA, BINITA, additional, CHANDAN, BINITA, additional, MERA, KENTARO, additional, TADA, KO-ICHI, additional, MIURA, NAOKI, additional, ONO, YOSHIKO, additional, TAKENOUCHI, KAZUNORI, additional, MAENOSONO, RYUICHI, additional, NAGASATO, TOMOKA, additional, HASHIGUCHI, TERUTO, additional, and MARUYAMA, IKURO, additional

Published
2011
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44. Sesamin Metabolites Induce an Endothelial Nitric Oxide-Dependent Vasorelaxation through Their Antioxidative Property-Independent Mechanisms: Possible Involvement of the Metabolites in the Antihypertensive Effect of Sesamin

Author

Nakano, Daisuke, primary, Kwak, Chol-Jun, additional, Fujii, Kiwako, additional, Ikemura, Kenji, additional, Satake, Aiko, additional, Ohkita, Mamoru, additional, Takaoka, Masanori, additional, Ono, Yoshiko, additional, Nakai, Masaaki, additional, Tomimori, Namino, additional, Kiso, Yoshinobu, additional, and Matsumura, Yasuo, additional

Published
2006
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48. The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosusstrain S-PT84

Author

Izumo, Takayuki, Maekawa, Toshihiro, Horii, Yuko, Fujisaki, Yoshiyuki, Ida, Masayuki, Furukawa, Yuichi, Ono, Yoshiko, Kiso, Yoshinobu, Kitagawa, Yoshinori, Shibata, Hiroshi, and Nagai, Katsuya

Abstract

Splenic sympathetic nerve activity (SNA) modulates cellular immune functions such as splenic natural killer cell activity. Lactobacillus pentosusstrain S-PT84 enhances splenic natural killer cell activity. Here, we examined whether S-PT84 affects splenic natural killer activity through splenic SNA in BALBc mice. Splenic SNA was significantly decreased following the administration of S-PT84. This phenomenon was inhibited by pretreatment with thioperamide (histamine H3receptor antagonist), suggesting that S-PT84 directly affected splenic SNA. Thioperamide also inhibited the increase in splenic natural killer activity by S-PT84. Thus, the change in splenic natural killer activity by S-PT84 may be partially modulated through SNA.

Published
2013
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49. Evaluation of Antioxidative Effects of Sesamin on the In vivoHepatic Reducing Abilities by a Radiofrequency ESR Method

Author

Tada, Mika, Ono, Yoshiko, Nakai, Masaaki, Harada, Masami, Shibata, Hiroshi, Kiso, Yoshinobu, and Ogata, Tateaki

Abstract

Antioxidative effects of sesamin (a mixture of sesamin and episesamin) were evaluated in the liver, kidney and inferior vena cava of living rats using a radiofrequency ESR method. TEMPOL, 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, was used as an in vivoredox probe, the half-life of which is believed to be correlated with the antioxidant status. The oral administration of sesamin (250 mg/kg rat weight) 3 h before ESR measurements shortened the half-life of TEMPOL in the liver by 10 - 15% as compared with the controls, but did not affect the other organs. This effect was maintained for at least 3 h after the administration, and then disappeared at 24 h, corresponding to the results of our preliminary pharmacokinetic studies. Changes in the reducing ability were observed only in the hepatic sites of the sesamin-treated rats. These findings suggest that sesamin exhibits effective antioxidant activity in the liver viamodulation of the intracellular redox status related to TEMPOL reduction.

Published
2013
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