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2. Surveillance for Pancreatic Cancer in High-Risk Individuals Leads to Improved Outcomes: A Propensity Score-Matched Analysis

Author

Klatte, Derk C.F., Boekestijn, Bas, Onnekink, Anke M., Dekker, Friedo W., van der Geest, Lydia G., Wasser, Martin N.J.M., Feshtali, Shirin, Mieog, J. Sven D., Luelmo, Saskia A.C., Morreau, Hans, Potjer, Thomas P., Inderson, Akin, Boonstra, Jurjen J., Vasen, Hans F.A., van Hooft, Jeanin E., Bonsing, Bert A., and van Leerdam, Monique E.

Published
2023
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3. Psychosocial issues of individuals undergoing surveillance for increased risk of melanoma and pancreatic cancer due to a germline CDKN2A variant: A focus group study.

Author

Klatte, Derk C. F., Onnekink, Anke M., Hinnen, Chris, van Doorn, Remco, Potjer, Thomas P., van Leerdam, Monique E., and Bleiker, Eveline M. A.

Abstract

Individuals with a germline CDKN2A pathogenic variant (PV) are at high risk of developing melanoma and pancreatic cancer and are therefore offered surveillance. The potential advantages and disadvantages associated with genetic testing and surveillance are discussed during medical counseling, although little is known about the associated psychosocial factors that are relevant to this population. This study sought to provide a qualitative exploration of psychosocial factors related to genetic testing and participation in skin and pancreatic surveillance in (potential) carriers of a CDKN2A PV. Fifteen individuals—both at‐risk individuals and confirmed variant carriers—participated in one of the three online focus groups. Pre‐defined discussion topics, including genetic testing, cancer surveillance, influence on lifestyle and family planning, were discussed. Patients reported that important reasons to engage in genetic testing included the possibility to participate in surveillance to gain control over their cancer risk and to get clarification on the potential carrier status of their children. We observed considerable differences in risk perception and experienced burden of surveillance. Knowledge of the PV has had a positive influence on lifestyle factors and altered attitudes toward life in some. Most participants were not aware of preimplantation genetic testing. This focus group study provided insight into a variety of psychosocial themes related to (potential) carriership of a CDKN2A PV. Future efforts should focus on identifying those who may benefit from additional psychosocial support, development of a centralized source of information, and assessing the knowledge, needs, and timing of counseling for family planning. [ABSTRACT FROM AUTHOR]

Published
2024
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4. THE ADDED VALUE OF BLOOD GLUCOSE MONITORING IN HIGH-RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE

Author

Bogdanski, Aleksander M., primary, Onnekink, Anke M., additional, Inderson, Akin, additional, Boekestijn, Bas, additional, Bonsing, Bert A., additional, Vasen, Hans F.A., additional, van Hooft, Jeanin E., additional, Boonstra, Jurjen J., additional, Mieog, J. Sven D., additional, Wasser, Martin N.J.M., additional, Feshtali, Shirin, additional, Potjer, Thomas P., additional, Klatte, Derk C.F., additional, and van Leerdam, Monique E., additional

Published
2024
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7. Comparison of pancreatic cancer outcomes diagnosed in surveillance and the general population: A propensity score-matched analysis.

Author

Klatte, Derk C.F., primary, Boekestijn, Bas, additional, Onnekink, Anke M., additional, Dekker, Friedo W., additional, van der Geest, Lydia G., additional, Wasser, Martin N.J.M.M., additional, Feshtali, Shirin, additional, Mieog, J. Sven D., additional, Morreau, Hans, additional, Potjer, Thomas P., additional, Inderson, Akin, additional, Boonstra, Jurjen J., additional, Vasen, Hans F.A., additional, Luelmo, Saskia, additional, van Hooft, Jeanin E., additional, Bonsing, Bert A., additional, and van Leerdam, Monique E., additional

Published
2023
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8. Reply

Author

Onnekink, Anke M., van Hooft, Jeanin E., Voermans, Rogier P., Gastroenterology and Hepatology, CCA - Cancer Treatment and Quality of Life, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Hepatology, Gastroenterology
Published
2023
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9. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Timmerhuis, Hester C., additional, Bac, Simon T., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas L., additional, Bosscha, Koop, additional, Bouwense, Stefan A.W., additional, Bruno, Marco J., additional, van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther C.J., additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel G.W., additional, van Eijck, Casper H.J., additional, Erkelens, Willemien G., additional, van Goor, Harry, additional, van Grinsven, Janneke, additional, Haveman, Jan-Willem, additional, van Hooft, Jeanin E., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten A.C., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier J., additional, Römkens, Tessa E.H., additional, van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel B.W., additional, Straathof, Jan Willem A., additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, van Wanrooij, Roy L., additional, Witteman, Ben J.M., additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2022
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10. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION):Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, Voermans, Rogier P., Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, and Voermans, Rogier P.

Abstract

Background & Aims: Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical Step-Up Approach in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that the endoscopic step-up approach might be preferred over the surgical step-up approach in patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both step-up approaches after a period of at least 5 years. Methods: In this long-term follow-up study, we reevaluated all clinical data on 83 patients (of the originally 98 included patients) from the TENSION trial who were still alive after the initial 6-month follow-up. The primary end point, similar to the TENSION trial, was a composite of death and major complications. Secondary end points included individual major complications, pancreaticocutaneous fistula, reinterventions, pancreatic insufficiency, and quality of life. Results: After a mean follow-up period of 7 years, the primary end point occurred in 27 patients (53%) in the endoscopy group and in 27 patients (57%) in the surgery group (risk ratio [RR], 0.93; 95% confidence interval [CI], 0.65–1.32; P = .688). Fewer pancreaticocutaneous fistulas were identified in the endoscopy group (8% vs 34%; RR, 0.23; 95% CI, 0.08–0.83). After the initial 6-month follow-up, the endoscopy group needed fewer reinterventions than the surgery group (7% vs 24%; RR, 0.29; 95% CI, 0.09–0.99). Pancreatic insufficiency and quality of life did not differ between groups. Conclusions: At long-term follow-up, the endoscopic step-up approach was not superior to the surgical step-up approach in reducing death or major complications in patients with infected necrotizing pancreatitis. However, patients assigned to the endoscopic approach developed overall fewer pancreaticocutaneous fistulas and needed fewer reinterventions after the initial 6-month follow-up. Netherlands Tria

Published
2022

11. Sa283 ENDOSCOPIC VERSUS SURGICAL STEP-UP APPROACH FOR INFECTED NECROTIZING PANCREATITIS: LONG-TERM FOLLOW-UP OF A MULTICENTER RANDOMIZED CONTROLLED TRIAL (EXTENSION)

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Bac, Simon, additional, Timmerhuis, Hester C., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bosscha, Koop, additional, Bouwense, Stefan A., additional, Bruno, Marco J., additional, Van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther, additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel, additional, Van Eijck, Casper H., additional, Erkelens, G. Willemien, additional, van Goor, Harry, additional, van Grevenstein, Helma, additional, van Grinsven, Janneke, additional, Haveman, Jan illem, additional, Hofker, Sijbrand H., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten, additional, Wanrooij, Roy V., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, De Ridder, Rogier, additional, Romkens, Tessa, additional, Van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel, additional, Straathof, Jan Willem, additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, Witteman, Ben, additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2021
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