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2. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.

Author

Makishima, H., Saiki, R., Nannya, Y., Korotev, S., Gurnari, C., Takeda, J., Momozawa, Y., Best, S., Krishnamurthy, P., Yoshizato, T., Atsuta, Y., Shiozawa, Y., Iijima-Yamashita, Y., Yoshida, K., Shiraishi, Y., Nagata, Y., Kakiuchi, N., Onizuka, M., Chiba, K., Tanaka, H., Kon, A., Ochi, Y., Nakagawa, M.M., Okuda, R., Mori, T., Yoda, A., Itonaga, H., Miyazaki, Y., Sanada, M., Ishikawa, T., Chiba, S., Tsurumi, H., Kasahara, S., Müller-Tidow, C., Takaori-Kondo, A., Ohyashiki, K., Kiguchi, T., Matsuda, F., Jansen, J.H., Polprasert, C., Blombery, P., Kamatani, Y., Miyano, S., Malcovati, L., Haferlach, T, Kubo, M., Cazzola, M., Kulasekararaj, A.G., Godley, L.A., Maciejewski, J.P., Ogawa, S., Makishima, H., Saiki, R., Nannya, Y., Korotev, S., Gurnari, C., Takeda, J., Momozawa, Y., Best, S., Krishnamurthy, P., Yoshizato, T., Atsuta, Y., Shiozawa, Y., Iijima-Yamashita, Y., Yoshida, K., Shiraishi, Y., Nagata, Y., Kakiuchi, N., Onizuka, M., Chiba, K., Tanaka, H., Kon, A., Ochi, Y., Nakagawa, M.M., Okuda, R., Mori, T., Yoda, A., Itonaga, H., Miyazaki, Y., Sanada, M., Ishikawa, T., Chiba, S., Tsurumi, H., Kasahara, S., Müller-Tidow, C., Takaori-Kondo, A., Ohyashiki, K., Kiguchi, T., Matsuda, F., Jansen, J.H., Polprasert, C., Blombery, P., Kamatani, Y., Miyano, S., Malcovati, L., Haferlach, T, Kubo, M., Cazzola, M., Kulasekararaj, A.G., Godley, L.A., Maciejewski, J.P., and Ogawa, S.

Abstract

Item does not contain fulltext, Germ line DDX41 variants have been implicated in late-onset myeloid neoplasms (MNs). Despite an increasing number of publications, many important features of DDX41-mutated MNs remain to be elucidated. Here we performed a comprehensive characterization of DDX41-mutated MNs, enrolling a total of 346 patients with DDX41 pathogenic/likely-pathogenic (P/LP) germ line variants and/or somatic mutations from 9082 MN patients, together with 525 first-degree relatives of DDX41-mutated and wild-type (WT) patients. P/LP DDX41 germ line variants explained ∼80% of known germ line predisposition to MNs in adults. These risk variants were 10-fold more enriched in Japanese MN cases (n = 4461) compared with the general population of Japan (n = 20 238). This enrichment of DDX41 risk alleles was much more prominent in male than female (20.7 vs 5.0). P/LP DDX41 variants conferred a large risk of developing MNs, which was negligible until 40 years of age but rapidly increased to 49% by 90 years of age. Patients with myelodysplastic syndromes (MDS) along with a DDX41-mutation rapidly progressed to acute myeloid leukemia (AML), which was however, confined to those having truncating variants. Comutation patterns at diagnosis and at progression to AML were substantially different between DDX41-mutated and WT cases, in which none of the comutations affected clinical outcomes. Even TP53 mutations made no exceptions and their dismal effect, including multihit allelic status, on survival was almost completely mitigated by the presence of DDX41 mutations. Finally, outcomes were not affected by the conventional risk stratifications including the revised/molecular International Prognostic Scoring System. Our findings establish that MDS with DDX41-mutation defines a unique subtype of MNs that is distinct from other MNs.

Published
2023

5. Fast Plasma Investigation for Magnetospheric Multiscale

Author

Pollock, C., primary, Moore, T., additional, Jacques, A., additional, Burch, J., additional, Gliese, U., additional, Saito, Y., additional, Omoto, T., additional, Avanov, L., additional, Barrie, A., additional, Coffey, V., additional, Dorelli, J., additional, Gershman, D., additional, Giles, B., additional, Rosnack, T., additional, Salo, C., additional, Yokota, S., additional, Adrian, M., additional, Aoustin, C., additional, Auletti, C., additional, Aung, S., additional, Bigio, V., additional, Cao, N., additional, Chandler, M., additional, Chornay, D., additional, Christian, K., additional, Clark, G., additional, Collinson, G., additional, Corris, T., additional, De Los Santos, A., additional, Devlin, R., additional, Diaz, T., additional, Dickerson, T., additional, Dickson, C., additional, Diekmann, A., additional, Diggs, F., additional, Duncan, C., additional, Figueroa-Vinas, A., additional, Firman, C., additional, Freeman, M., additional, Galassi, N., additional, Garcia, K., additional, Goodhart, G., additional, Guererro, D., additional, Hageman, J., additional, Hanley, J., additional, Hemminger, E., additional, Holland, M., additional, Hutchins, M., additional, James, T., additional, Jones, W., additional, Kreisler, S., additional, Kujawski, J., additional, Lavu, V., additional, Lobell, J., additional, LeCompte, E., additional, Lukemire, A., additional, MacDonald, E., additional, Mariano, A., additional, Mukai, T., additional, Narayanan, K., additional, Nguyan, Q., additional, Onizuka, M., additional, Paterson, W., additional, Persyn, S., additional, Piepgrass, B., additional, Cheney, F., additional, Rager, A., additional, Raghuram, T., additional, Ramil, A., additional, Reichenthal, L., additional, Rodriguez, H., additional, Rouzaud, J., additional, Rucker, A., additional, Samara, M., additional, Sauvaud, J.-A., additional, Schuster, D., additional, Shappirio, M., additional, Shelton, K., additional, Sher, D., additional, Smith, D., additional, Smith, K., additional, Smith, S., additional, Steinfeld, D., additional, Szymkiewicz, R., additional, Tanimoto, K., additional, Taylor, J., additional, Tucker, C., additional, Tull, K., additional, Uhl, A., additional, Vloet, J., additional, Walpole, P., additional, Weidner, S., additional, White, D., additional, Winkert, G., additional, Yeh, P.-S., additional, and Zeuch, M., additional

Published
2016
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8. Fast Plasma Investigation for Magnetospheric Multiscale

Author

Pollock, C., Moore, T., Jacques, A., Burch, J., Gliese, U., Saito, Y., Omoto, T., Avanov, L., Barrie, A., Coffey, V., Dorelli, J., Gershman, D., Giles, B., Rosnack, T., Salo, C., Yokota, S., Adrian, M., Aoustin, C., Auletti, C., Aung, S., Bigio, V., Cao, N., Chandler, M., Chornay, D., Christian, K., Clark, G., Collinson, G., Corris, T., De Los Santos, A., Devlin, R., Diaz, T., Dickerson, T., Dickson, C., Diekmann, A., Diggs, F., Duncan, C., Figueroa-Vinas, A., Firman, C., Freeman, M., Galassi, N., Garcia, K., Goodhart, G., Guererro, D., Hageman, J., Hanley, J., Hemminger, E., Holland, M., Hutchins, M., James, T., Jones, W., Kreisler, S., Kujawski, J., Lavu, V., Lobell, J., LeCompte, E., Lukemire, A., MacDonald, E., Mariano, A., Mukai, T., Narayanan, K., Nguyan, Q., Onizuka, M., Paterson, W., Persyn, S., Piepgrass, B., Cheney, F., Rager, A., Raghuram, T., Ramil, A., Reichenthal, L., Rodriguez, H., Rouzaud, J., Rucker, A., Saito, Y., Samara, M., Sauvaud, J.-A., Schuster, D., Shappirio, M., Shelton, K., Sher, D., Smith, D., Smith, K., Smith, S., Steinfeld, D., Szymkiewicz, R., Tanimoto, K., Taylor, J., Tucker, C., Tull, K., Uhl, A., Vloet, J., Walpole, P., Weidner, S., White, D., Winkert, G., Yeh, P.-S., and Zeuch, M.

Published
2016
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9. P741: DDX41 MUTATIONS DEFINE A UNIQUE SUBTYPE OF MYELOID NEOPLASMS.

Author

Makishima, H., primary, Saiki, R., additional, Nannya, Y., additional, Korotev, S., additional, Gurnari, C., additional, Takeda, J., additional, Momozawa, Y., additional, Best, S., additional, Krishnamurthy, P., additional, Yoshizato, T., additional, Atsuta, Y., additional, Shiozawa, Y., additional, Iijima-Yamashita, Y., additional, Yoshida, K., additional, Shiraishi, Y., additional, Nagata, Y., additional, Kakiuchi, N., additional, Onizuka, M., additional, Chiba, K., additional, Tanaka, H., additional, Kon, A., additional, Ochi, Y., additional, Nakagawa, M., additional, Okuda, R., additional, Mori, T., additional, Itonaga, H., additional, Miyazaki, Y., additional, Sanada, M., additional, Tsurumi, H., additional, Kasahara, S., additional, Müller-Tidow, C., additional, Takaori-Kondo, A., additional, Ohyashiki, K., additional, Kiguchi, T., additional, Matsuda, F., additional, Jansen, J., additional, Polprasert, C., additional, Miyano, S., additional, Malcovati, L., additional, Haferlach, T., additional, Kubo, M., additional, Cazzola, M., additional, Kulasekararaj, A., additional, Godley, L., additional, Maciejewski, J., additional, and Ogawa, S., additional

Published
2022
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12. Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients

Author

Kihara, R, Nagata, Y, Kiyoi, H, Kato, T, Yamamoto, E, Suzuki, K, Chen, F, Asou, N, Ohtake, S, Miyawaki, S, Miyazaki, Y, Sakura, T, Ozawa, Y, Usui, N, Kanamori, H, Kiguchi, T, Imai, K, Uike, N, Kimura, F, Kitamura, K, Nakaseko, C, Onizuka, M, Takeshita, A, Ishida, F, Suzushima, H, Kato, Y, Miwa, H, Shiraishi, Y, Chiba, K, Tanaka, H, Miyano, S, Ogawa, S, and Naoe, T

Published
2014
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13. O09 - Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution: MYELOID NEOPLASMS WITH GERMLINE AND SOMATIC DDX41 MUTATIONS

Author

Makishima, H., Nannya, Y., Momozawa, Y., Gurnari, C., Kulasekararaj, A., Yoshizato, T., Takeda, J., Atsuta, Y., Shiozawa, Y., Iijima-Yamashita, Y., Saiki, R., Yoshida, K., Shiraishi, Y., Nagata, Y., Onizuka, M., Nakagawa, M., Itonaga, H., Kanda, Y., Miyazaki, Y., Sanada, M., Tsurumi, H., Kasahara, S., Kondo-Takaori, A., Ohyashiki, K., Kiguchi, T., Matsuda, F., Jansen, J., Papaemmanuil, E., Creignou, M., Tobiasson, M., Hellström-Lindberg, E., Polprasert, C., Malcovati, L., Cazzola, M., Haferlach, T., Maciejewski, J., Kamatani, Y., Miyano, S., and Ogawa, S.

Published
2021
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14. Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution

Author

Makishima, H., primary, Nannya, Y., additional, Momozawa, Y., additional, Gurnari, C., additional, Kulasekararaj, A., additional, Yoshizato, T., additional, Takeda, J., additional, Atsuta, Y., additional, Shiozawa, Y., additional, Iijima-Yamashita, Y., additional, Saiki, R., additional, Yoshida, K., additional, Shiraishi, Y., additional, Nagata, Y., additional, Onizuka, M., additional, Nakagawa, M., additional, Itonaga, H., additional, Kanda, Y., additional, Miyazaki, Y., additional, Sanada, M., additional, Tsurumi, H., additional, Kasahara, S., additional, Kondo-Takaori, A., additional, Ohyashiki, K., additional, Kiguchi, T., additional, Matsuda, F., additional, Jansen, J., additional, Papaemmanuil, E., additional, Creignou, M., additional, Tobiasson, M., additional, Hellström-Lindberg, E., additional, Polprasert, C., additional, Malcovati, L., additional, Cazzola, M., additional, Haferlach, T., additional, Maciejewski, J., additional, Kamatani, Y., additional, Miyano, S., additional, and Ogawa, S., additional

Published
2021
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23. The Small Satellite-Based, Imaging X-Ray Polarimeter Explorer (IXPE) Mission

Author

Deininger, W. D., Masciarelli, J., Kalinowski, W., Hibbard, G., Wedmore, J., Gray, S., Ferrie, M., Dolan, D., Onizuka, M., Seek, T., Sharma, D., Mitchell, S., Ferrant, K., Boree, C., Antoniak, S., Mize, R., Alexander, C., Foster, M., O'Dell, S. L., Ramsey, B. D., Santoli, F., Pinchera, M., Minuti, M., Trois, A., Monte, E. Del, and Muleri, F.

Subjects
explorer, x-ray, mission, Astrophysics::High Energy Astrophysical Phenomena, polarimeter, satellite, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, base, small
Abstract

The Imaging X-ray Polarimeter Explorer (IXPE) focuses on high energy astrophysics in the 2—8 keV x-ray band. IXPE is designed to explore general relativistic and quantum physics effects of gravity, energy, electric and magnetic fields at extreme limits. IXPE, a NASA Small Explorer (SMEX) Mission, will add new dimensions to on-orbit x-ray science: polarization degree, polarization angle and extended object polarization imaging. Polarization uniquely probes physical anisotropies that are not otherwise measurable—ordered magnetic fields, aspheric matter distributions, or general relativistic coupling to black-hole spin. Detailed imaging enables the specific properties of extended x-ray sources to be differentiated. The IXPE Observatory consists of spacecraft and payload modules built up in parallel to form the Observatory during system integration and test. The payload includes three polarization-sensitive, x-ray detector arrays paired with three x-ray mirror module assemblies (MMA). A deployable boom provides the correct separation (focal length) between the detector units and MMAs. Currently, the boom has been delivered, all four detectors units (DU) are complete, the detectors service unit (DSU) is complete, instrument system testing has been completed (DSU with 3 DUs), three of four MMAs is built and all spacecraft components except the solar array have been delivered along with the spacecraft and payload structures. Payload and spacecraft integration and test (I&T) started in March 2020. This paper overviews the flight segment (the Observatory, payload, and spacecraft implementation concepts) with emphasis on the build status and summarizes the launch segment. Launch is planned to occur on a Falcon 9 launch vehicle during Summer 2021. The paper summarizes the impacts of switching from the ‘design-to baseline’ of Pegasus XL to the selected launch vehicle for flight, Falcon 9. COVID-19 impacts to the Project are also summarized. The paper will close with a summary of the mission development status. The Project is firmly into the build phase for both the spacecraft and payload and rapidly approaching Observatory I&T.

Published
2020

26. Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphoblastic leukaemia in first complete remission: comparisons between related and unrelated, and myeloablative and reduced-intensity conditioning transplantation: P915

Author

Nishiwaki, S., Inamoto, Y., Sakamaki, H., Kurokawa, M., Iida, H., Ogawa, H., Fukuda, T., Ozawa, Y., Kobayashi, N., Kasai, M., Mori, T., Iwato, K., Yoshida, T., Onizuka, M., Kawa, K., Morisima, Y., Suzuki, R., Atsuta, Y., and Miyamura, K.

Published
2011

30. S118 IMPACT OF PRE-TRANSPLANT DONOR-SPECIFIC ANTI-HLA ANTIBODIES IN CORD BLOOD TRANSPLANTATION ON BEHALF OF THE TRANSPLANT COMPLICATIONS WORKING GROUP OF JSHCT

Author

Fuji, S., primary, Oshima, K., additional, Ohashi, K., additional, Sawa, M., additional, Saito, K., additional, Eto, T., additional, Tanaka, M., additional, Onizuka, M., additional, Nakamae, H., additional, Shiratori, S., additional, Ozawa, Y., additional, Hidaka, M., additional, Nagamura-Inoue, T., additional, Tanaka, H., additional, Fukuda, T., additional, Ichinohe, T., additional, Atsuta, Y., additional, and Ogata, M., additional

Published
2019
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31. PF756 DONOR UNC-93 HOMOLOG B1 GENETIC VARIATION PREDICTS SURVIVAL OUTCOMES AFTER UNRELATED BONE MARROW TRANSPLANTATION

Author

Uchino, K., primary, Mizuno, S., additional, Horio, T., additional, Mizutani, M., additional, Nakamura, A., additional, Takasugi, S., additional, Hanamura, I., additional, Vu, L., additional, Kodera, Y., additional, Espinoza, J.L., additional, Onizuka, M., additional, Kashiwase, K., additional, Morishima, Y., additional, Fukuda, T., additional, Doki, N., additional, Miyamura, K., additional, Mori, T., additional, Morishita, E., additional, Nakao, S., additional, and Takami, A., additional

Published
2019
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32. PF179 DIFFERENT IMPACT OF BCR BREAKPOINT ON THE OUTCOME OF ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION FROM DIFFERENT GRAFT SOURCE FOR PH+ALL IN THE ERA OF TKI

Author

Nishiwaki, S., primary, Mizuta, S., additional, Ohashi, K., additional, Fukuda, T., additional, Uchida, N., additional, Kanamori, H., additional, Onizuka, M., additional, Ozawa, Y., additional, Tanaka, J., additional, Ichinohe, T., additional, Atsuta, Y., additional, and Kako, S., additional

Published
2019
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33. S135 NGS-BASED COPY-NUMBER ANALYSIS IN MORE THAN 2,000 PATIENTS WITH MYELOID NEOPLASMS

Author

Saiki, R., primary, Shiozawa, Y., additional, Yoshizato, T., additional, Nanya, Y., additional, Takeda, J., additional, Yoshida, K., additional, Shiraishi, Y., additional, Tanaka, H., additional, Chiba, K., additional, Atsuta, Y., additional, Onizuka, M., additional, Itonaga, H., additional, Sanada, M., additional, Kanda, Y., additional, Przychodzen, B., additional, Sekeres, M.A., additional, Guinta, K.M., additional, Saunthararajah, Y., additional, Shih, L.-Y., additional, Miyawaki, S., additional, Nakamaki, T., additional, Taguchi, M., additional, Fuji, S., additional, Sasaki, N., additional, Uoshima, N., additional, Ueda, Y., additional, Miyazaki, Y., additional, Usuki, K., additional, Imada, K., additional, Takaori-Kondo, A., additional, Chiba, S., additional, Kasahara, S., additional, Kiguchi, T., additional, Tsurumi, H., additional, Malcovati, L., additional, Cazzola, M., additional, Ishikawa, T., additional, Miyano, S., additional, Maciejewski, J.P., additional, Makishima, H., additional, and Ogawa, S., additional

Published
2019
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37. P2.17-004 Salvage Surgery for Pulmonary Metastases in Patients with Testicular Germ Cell Tumors

Author

Kikuchi, S., primary, Sekine, Y., additional, Sugai, K., additional, Kawamura, T., additional, Ueda, S., additional, Saeki, Y., additional, Kobayashi, N., additional, Goto, Y., additional, Minami, Y., additional, Onizuka, M., additional, Kojima, T., additional, Kawai, K., additional, Nishiyama, H., additional, Ichimura, H., additional, and Sato, Y., additional

Published
2017
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39. Impact of low-dose TBI on outcomes of reduced intensity conditioning allogeneic hematopoietic stem cell transplantation for AML

Author

Aoki, J, primary, Seo, S, additional, Kanamori, H, additional, Tanaka, M, additional, Fukuda, T, additional, Onizuka, M, additional, Kobayashi, N, additional, Kondo, T, additional, Sawa, M, additional, Uchida, N, additional, Iwato, K, additional, Icihnohe, T, additional, Atsuta, Y, additional, Yano, S, additional, and Takami, A, additional

Published
2015
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40. Sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: Incidence, risk factors and outcomes

Author

Yakushijin, K, primary, Atsuta, Y, additional, Doki, N, additional, Yokota, A, additional, Kanamori, H, additional, Miyamoto, T, additional, Ohwada, C, additional, Miyamura, K, additional, Nawa, Y, additional, Kurokawa, M, additional, Mizuno, I, additional, Mori, T, additional, Onizuka, M, additional, Taguchi, J, additional, Ichinohe, T, additional, Yabe, H, additional, Morishima, Y, additional, Kato, K, additional, Suzuki, R, additional, and Fukuda, T, additional

Published
2015
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41. The Significance of Incomplete Stent Apposition in Patients Undergoing Stenting of Internal Carotid Artery Stenosis

Author

Onizuka, M., Kazekawa, K., Nagata, S., Tsutsumi, M., Aikawa, H., Tomokiyo, M., Iko, M., Tomonobu Kodama, Nii, K., Matsubara, S., and Tanaka, A.

Subjects
Aged, 80 and over, Male, Ticlopidine, Interventional, Aspirin, Middle Aged, equipment and supplies, Prognosis, Radiography, Interventional, Magnetic Resonance Imaging, Brain Ischemia, Carotid Arteries, Recurrence, Humans, Carotid Stenosis, Female, Stents, cardiovascular diseases, Angioplasty, Balloon, Platelet Aggregation Inhibitors, Aged, Follow-Up Studies, Retrospective Studies
Abstract

BACKGROUND AND PURPOSE: Incomplete stent apposition after carotid angioplasty and stent placement (CAS) is often seen but little is known about how the incomplete attachment goes after stent placement. For example, some may change into restenosis around the stent edge and some may remain unchanged. The purpose of this study is to clarify the morphologic prognosis of an incomplete stent apposition at the stent edge. METHODS: CAS was attempted on 135 consecutive stenotic lesions (124 patients). Angiograms were then evaluated immediately after the procedure. An incomplete stent apposition at stent edge was found in 15 patients, and all of them were followed up by angiography and MR imaging with antiplatelet therapy. RESULTS: No ischemic event caused by the lesions occurred during the mean follow-up period of 11 months (from 4 to 32 months). The angiography findings of 15 lesions at a mean of 8.8 months (from 2 to 28 months) after CAS showed that all remained unchanged. No patients required any additional intervention. No new ischemic lesions were detected in any of the 15 patients who underwent follow-up MR imaging at a mean of 10 months (from 2 to 32 months) after CAS. CONCLUSION: In this study, the existence of a segment of incomplete stent apposition had no adverse morphologic or clinical effect.

Published
2006

44. Three-dimensional structures for high saturation signals and crosstalk suppression in 1.20 μm pixel back-illuminated CMOS image sensor

Author

Shinohara, T., primary, Watanabe, K., additional, Arakawa, S., additional, Kawashima, H., additional, Kawashima, A., additional, Abe, T., additional, Yanagita, T., additional, Ohta, K., additional, Inada, Y., additional, Onizuka, M., additional, Nakayama, H., additional, Tateshita, Y., additional, Morikawa, T., additional, Ohno, K., additional, Sugimoto, D., additional, Kadomura, S., additional, and Hirayama, T., additional

Published
2013
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46. Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22

Author

Kikuchi, T., Naruse, T.K., Onizuka, M., Li, S., Kimura, T., Oka, A., Morishima, Y., Kulski, J.K., Ichimiya, S., Sato, N., Inoko, H., Kikuchi, T., Naruse, T.K., Onizuka, M., Li, S., Kimura, T., Oka, A., Morishima, Y., Kulski, J.K., Ichimiya, S., Sato, N., and Inoko, H.

Abstract

Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gene polymorphisms, such as minor histocompatibility antigens (mHas) and genes coding for cytokines. However, a detailed genetic background for aGVHD has not yet been established. To find novel susceptibility and/or protective loci for aGVHD, a whole genome-wide association study of donors and recipients needs to be performed. As the first step to such a study, we retrospectively analyzed polymorphisms of 155 microsatellite markers spread across the long arm of chromosome 22 in 70 pairs of HLA-matched unrelated BMT donors and recipients. We performed individual typing and then compared the markers' allele frequencies (1) between all the aGVHD (grades III and IV GVHD) and GVHD-free (grade 0 GVHD) groups in donors and recipients and (2) between the aGVHD and aGVHD-free groups in donor/recipient pairs that were matched and mismatched for the microsatellite marker's allele. Screening of the microsatellite markers revealed five loci with a significant difference between the aGVHD and GVHD-free groups and revealed eight loci on chromosome 22, where the microsatellite allele mismatched markers were associated with aGVHD. This screening analysis suggests that several aGVHD-associated susceptible and protective loci exist on chromosome 22, which may encompass novel gene regions that need to be elucidated for their role in aGVHD.

Published
2007

50. A decision analysis of allogeneic hematopoietic stem cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor

Author

Kako, S, primary, Morita, S, additional, Sakamaki, H, additional, Ogawa, H, additional, Fukuda, T, additional, Takahashi, S, additional, Kanamori, H, additional, Onizuka, M, additional, Iwato, K, additional, Suzuki, R, additional, Atsuta, Y, additional, Kyo, T, additional, Sakura, T, additional, Jinnai, I, additional, Takeuchi, J, additional, Miyazaki, Y, additional, Miyawaki, S, additional, Ohnishi, K, additional, Naoe, T, additional, and Kanda, Y, additional

Published
2010
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