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1. Association Between Timed Up-and-Go Test and Future Changes in the Frailty Status in a Longitudinal Study of Japanese Community-Dwelling Older Adults

Author

Wada Y, Shojima K, Tamaki K, Mori T, Kusunoki H, Onishi M, Tsuji S, Matsuzawa R, Nagai K, Sano K, Hashimoto K, Goto M, Nagasawa Y, and Shinmura K

Subjects
frailty, cardiovascular health study, older adults, physical function, timed up-and-go test, Geriatrics, RC952-954.6
Abstract

Yosuke Wada,1,2 Kensaku Shojima,1 Kayoko Tamaki,1 Takara Mori,1,3 Hiroshi Kusunoki,1,4 Masaaki Onishi,5 Shotaro Tsuji,5,6 Ryota Matsuzawa,7 Koutatsu Nagai,7 Kyoko Sano,8 Kana Hashimoto,9 Masashi Goto,10 Yasuyuki Nagasawa,1 Ken Shinmura1,10 1Department of General Internal Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Japan; 2Roppou Clinic, Toyooka, Hyogo, Japan; 3Amagasaki Medical COOP Honden Clinic, Amagasaki, Hyogo, Japan; 4Department of Internal Medicine, Osaka Dental University, Hirakata, Japan; 5Department of Orthopedic Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Japan; 6Department of Orthopedic Surgery, Tatsuno City Hospital, Tatsuno, Japan; 7Department of Physical Therapy, School of Rehabilitation, Hyogo Medical University, Kobe, Japan; 8Takarazuka Rehabilitation Hospital, Takarazuka, Japan; 9School of Pharmacy, Hyogo Medical University, Kobe, Japan; 10Department of General Medicine and Community Health Science, Hyogo Medical University, Sasayama Medical Center, Tambasasayama, JapanCorrespondence: Ken Shinmura, Department of General Internal Medicine, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan, Tel +81-798-45-6865, Fax +81-798-45-6977, Email ke-shimmura@hyo-med.ac.jpPurpose: This study aimed to evaluate the relationship between timed up-and-go (TUG) test time and changes in frailty status in a longitudinal cohort study of rural Japanese older adults.Patients and Methods: This prospective cohort study included 545 community-dwelling older adults. Initial and 2-year follow-up surveys were conducted. We compared the number of the Japanese version of the Cardiovascular Health Study components during the follow-up period and classified the participants into three groups: the favorable change, unchanged as prefrail, and unfavorable change groups. Associations between changes in frailty status and TUG time in the first survey were examined. The predictive ability of the TUG test was determined using the receiver operating characteristic (ROC) curve.Results: The favorable change group comprised 315 individuals (57.8%), the unchanged as prefrail group 105 (19.2%), and the unfavorable change group 125 (22.9%). TUG time was associated with the favorable and unfavorable changes after adjustment for covariates (OR 0.79, 95% CI 0.68– 0.92, P=0.001 and OR 1.27, 95% CI 1.09– 1.49, P=0.002). The ROC curve of TUG time as a predictor of unfavorable changes showed an area under the curve of 0.59. A cut-off point of TUG was calculated as 6.3 s with 49.6% sensitivity and 66.0% specificity.Conclusion: TUG time in the first survey was significantly associated with changes in frailty status 2 years later. However, its predictive value as a stand-alone test is limited and has the potential to predict future changes in the frailty status in older adults in combination with other tests.Keywords: frailty, cardiovascular health study, older adults, physical function, timed up-and-go test

Published
2023

2. Isotropy of cosmic rays beyond $10^{20}$ eV favors their heavy mass composition

Author

Telescope Array Collaboration, Abbasi, R. U., Abe, Y., Abu-Zayyad, T., Allen, M., Arai, Y., Arimura, R., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Buckland, I., Cheon, B. G., Chikawa, M., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Furlich, G., Globus, N., Gonzalez, R., Hanlon, W., Hayashida, N., He, H., Hibi, R., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwasaki, A., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawakami, S., Kawata, K., Kharuk, I., Kido, E., Kim, H. B., Kim, J. H., Kim, S. W., Kimura, Y., Komae, I., Kuzmin, V., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., Lundquist, J. P., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Mizuno, K., Murakami, M., Myers, I., Nagataki, S., Nakai, K., Nakamura, T., Nishio, E., Nonaka, T., Oda, H., Ogio, S., Onishi, M., Ohoka, H., Okazaki, N., Oku, Y., Okuda, T., Omura, Y., Ono, M., Oshima, A., Oshima, H., Ozawa, S., Park, I. H., Park, K. Y., Potts, M., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rott, C., Rubtsov, G. I., Ryu, D., Sagawa, H., Saito, R., Sakaki, N., Sako, T., Sakurai, N., Sato, D., Sato, K., Sato, S., Sekino, K., Shah, P. D., Shibata, N., Shibata, T., Shikita, J., Shimodaira, H., Shin, B. K., Shin, H. S., Shinto, D., Smith, J. D., Sokolsky, P., Stokes, B. T., Stroman, T. A., Takagi, Y., Takahashi, K., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsuda, R., Tsunesada, Y., Udo, S., Urban, F., Warren, D., Wong, T., Yamazaki, K., Yashiro, K., Yoshida, F., Zhezher, Y., and Zundel, Z.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report an estimation of the injected mass composition of ultra-high energy cosmic rays (UHECRs) at energies higher than 10 EeV. The composition is inferred from an energy-dependent sky distribution of UHECR events observed by the Telescope Array surface detector by comparing it to the Large Scale Structure of the local Universe. In the case of negligible extra-galactic magnetic fields the results are consistent with a relatively heavy injected composition at E ~ 10 EeV that becomes lighter up to E ~ 100 EeV, while the composition at E > 100 EeV is very heavy. The latter is true even in the presence of highest experimentally allowed extra-galactic magnetic fields, while the composition at lower energies can be light if a strong EGMF is present. The effect of the uncertainty in the galactic magnetic field on these results is subdominant., Comment: 8 pages, 3 figures, accepted for publication in PRL

Published
2024

3. Mass composition of ultra-high energy cosmic rays from distribution of their arrival directions with the Telescope Array

Author

Telescope Array Collaboration, Abbasi, R. U., Abe, Y., Abu-Zayyad, T., Allen, M., Arai, Y., Arimura, R., Barcikowski, E., Belz, J. W., Bergman, D. R., Blake, S. A., Buckland, I., Cheon, B. G., Chikawa, M., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Furlich, G., Globus, N., Gonzalez, R., Hanlon, W., Hayashida, N., He, H., Hibi, R., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwasaki, A., Jeong, H. M., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawakami, S., Kawata, K., Kharuk, I., Kido, E., Kim, H. B., Kim, J. H., Kim, S. W., Kimura, Y., Komae, I., Kuzmin, V., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lubsandorzhiev, B., Lundquist, J. P., Matsumiya, H., Matsuyama, T., Matthews, J. N., Mayta, R., Mizuno, K., Murakami, M., Myers, I., Nagataki, S., Nakai, K., Nakamura, T., Nishio, E., Nonaka, T., Oda, H., Ogio, S., Onishi, M., Ohoka, H., Okazaki, N., Oku, Y., Okuda, T., Omura, Y., Ono, M., Oshima, A., Oshima, H., Ozawa, S., Park, I. H., Park, K. Y., Potts, M., Pshirkov, M. S., Remington, J., Rodriguez, D. C., Rott, C., Rubtsov, G. I., Ryu, D., Sagawa, H., Saito, R., Sakaki, N., Sako, T., Sakurai, N., Sato, D., Sato, K., Sato, S., Sekino, K., Shah, P. D., Shibata, N., Shibata, T., Shikita, J., Shimodaira, H., Shin, B. K., Shin, H. S., Shinto, D., Smith, J. D., Sokolsky, P., Stokes, B. T., Stroman, T. A., Takagi, Y., Takahashi, K., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, K., Tanaka, M., Tanoue, Y., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsuda, R., Tsunesada, Y., Udo, S., Urban, F., Warren, D., Wong, T., Yamazaki, K., Yashiro, K., Yoshida, F., Zhezher, Y., and Zundel, Z.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We use a new method to estimate the injected mass composition of ultrahigh cosmic rays (UHECRs) at energies higher than 10 EeV. The method is based on comparison of the energy-dependent distribution of cosmic ray arrival directions as measured by the Telescope Array experiment (TA) with that calculated in a given putative model of UHECR under the assumption that sources trace the large-scale structure (LSS) of the Universe. As we report in the companion letter, the TA data show large deflections with respect to the LSS which can be explained, assuming small extra-galactic magnetic fields (EGMF), by an intermediate composition changing to a heavy one (iron) in the highest energy bin. Here we show that these results are robust to uncertainties in UHECR injection spectra, the energy scale of the experiment and galactic magnetic fields (GMF). The assumption of weak EGMF, however, strongly affects this interpretation at all but the highest energies E > 100 EeV, where the remarkable isotropy of the data implies a heavy injected composition even in the case of strong EGMF. This result also holds if UHECR sources are as rare as $2 \times 10^{-5}$ Mpc$^{-3}$, that is the conservative lower limit for the source number density., Comment: 18 pages, 11 figures, accepted for publication in PRD

Published
2024

4. Observation of Declination Dependence in the Cosmic Ray Energy Spectrum

Author

The Telescope Array Collaboration, Abbasi, R. U., Abu-Zayyad, T., Allen, M., Belz, J. W., Bergman, D. R., Buckland, I., Campbell, W., Cheon, B. G., Endo, K., Fedynitch, A., Fujii, T., Fujisue, K., Fujita, K., Fukushima, M., Furlich, G., Gerber, Z., Globus, N., Hanlon, W., Hayashida, N., He, H., Hibino, K., Higuchi, R., Ikeda, D., Ishii, T., Ivanov, D., Jeong, S., Jui, C. C. H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kawachi, Y., Kawata, K., Kharuk, I., Kido, E., Kim, H. B., Kim, J. H., Kim, S. W., Kobo, R., Komae, I., Komatsu, K., Komori, K., Koyama, C., Kudenko, M., Kuroiwa, M., Kusumori, Y., Kuznetsov, M., Kwon, Y. J., Lee, K. H., Lee, M. J., Lubsandorzhiev, B., Lundquist, J. P., Matsuzawa, A., Matthews, J. A., Matthews, J. N., Mizuno, K., Mori, M., Murakami, M., Nagataki, S., Nakahara, M., Nakamura, T., Nakayama, T., Nakayama, Y., Nonaka, T., Ogio, S., Ohoka, H., Okazaki, N., Onishi, M., Oshima, A., Oshima, H., Ozawa, S., Park, I. H., Park, K. Y., Potts, M., Przybylak, M., Pshirkov, M. S., Remington, J., Rott, C., Rubtsov, G. I., Ryu, D., Sagawa, H., Sakaki, N., Sakamoto, R., Sako, T., Sakurai, N., Sakurai, S., Sato, D., Sato, S., Sekino, K., Shibata, T., Shikita, J., Shimodaira, H., Shin, B. K., Shin, H. S., Shinozaki, K., Smith, J. D., Sokolsky, P., Stokes, B. T., Stroman, T. A., Takagi, Y., Takahashi, K., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, K., Tanaka, M., Thomas, S. B., Thomson, G. B., Tinyakov, P., Tkachev, I., Tomida, T., Troitsky, S., Tsunesada, Y., Udo, S., Urban, F., Vaiman, I. A., Vrábel, M., Warren, D., Yamazaki, K., Zhezher, Y., Zundel, Z., and Zvirzdin, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on an observation of the difference between northern and southern skies of the ultrahigh energy cosmic ray energy spectrum with a significance of ${\sim}8\sigma$. We use measurements from the two largest experiments$\unicode{x2014}$the Telescope Array observing the northern hemisphere and the Pierre Auger Observatory viewing the southern hemisphere. Since the comparison of two measurements from different observatories introduces the issue of possible systematic differences between detectors and analyses, we validate the methodology of the comparison by examining the region of the sky where the apertures of the two observatories overlap. Although the spectra differ in this region, we find that there is only a $1.8\sigma$ difference between the spectrum measurements when anisotropic regions are removed and a fiducial cut in the aperture is applied., Comment: 8 pages, 6 figures

Published
2024

5. Empirical research on the utility of a preparation manual for a disaster medical response drill

Author

Arai T, Ohta S, Onishi M, Taniguchi M, Tsurukiri J, Kumasaka K, Nagata K, Suzuki K, Harigae K, and Yukioka T

Subjects
disaster medicine, textual analysis, database, quality assessment, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Takao Arai,1 Shoichi Ohta,1 Masaki Onishi,2 Miyu Taniguchi,1 Junya Tsurukiri,1 Kenichiro Kumasaka,1 Katsuhiro Nagata,1 Kensuke Suzuki,3 Ken Harigae,4 Tetsuo Yukioka1 1Department of Emergency and Critical Care Medicine, Trauma and Emergency Center, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan; 2National Institute of Advanced Industrial Science and Technology, Tokyo, Japan; 3Faculty of Medical Science, Nippon Sport Science University, Yokohama, Kanagawa, Japan; 4Emergency Department, Hino Municipal Hospital, Hino, Tokyo, Japan Purpose: It is difficult for emergency physicians to plan and execute a disaster medical response drill while conducting their daily work activities. Readily available drill preparation manuals are therefore essential, alongside assessment methods to ensure quality. Here, we propose email text analysis as a manual assessment method, and investigate its validity. Methods: The preparation status of two similar large-scale disaster medical response drills were compared. All email texts exchanged during the preparation stage were analyzed, and frequently appearing words (quality element) and word counts (quantity element) were compared between Drill 1, which was organized without a manual, and Drill 2, organized with a manual. Results: Word frequency analysis revealed that the key components of the manual (visualization of necessary work, preparation of documents in a certain format, and clarification of aims of the drill) contributed to the effectiveness of the preparation process for Drill 2. Furthermore, work volume during the preparation for Drill 2 was decreased by 41.9% from that during the preparation for Drill 1. Conclusion: Preparation of a high-quality manual is crucial so that emergency physicians can plan and execute a disaster medical response drill. Email text analysis can serve as an objective method assessing the quality of manuals. Keywords: disaster medicine, textual analysis, database, quality assessment

Published
2017

9. The energy spectrum of cosmic rays measured by the Telescope Array using 10 years of fluorescence detector data

Author

Abbasi, R.U., Abe, Y., Abu-Zayyad, T., Allen, M., Arai, Y., Arimura, R., Barcikowski, E., Belz, J.W., Bergman, D.R., Blake, S.A., Buckland, I., Cheon, B.G., Chikawa, M., Fedynitch, A., Fujii, T., Fujisue, K., Fujita, K., Fujiwara, R., Fukushima, M., Furlich, G., Gerber, Z., Globus, N., Hanlon, W., Hayashida, N., He, H., Hibi, R., Hibino, K., Higuchi, R., Honda, K., Ikeda, D., Inoue, N., Ishii, T., Ito, H., Ivanov, D., Iwasaki, A., Jeong, H.M., Jeong, S., Jui, C.C.H., Kadota, K., Kakimoto, F., Kalashev, O., Kasahara, K., Kasami, S., Kawakami, S., Kawata, K., Kharuk, I., Kido, E., Kim, H.B., Kim, J.H., Kim, S.W., Kimura, Y., Komae, I., Komori, K., Kusumori, Y., Kuznetsov, M., Kwon, Y.J., Lee, K.H., Lee, M.J., Lubsandorzhiev, B., Lundquist, J.P., Matsuyama, T., Matthews, J.A., Matthews, J.N., Mayta, R., Miyashita, K., Mizuno, K., Mori, M., Murakami, M., Myers, I., Nagataki, S., Nakai, K., Nakamura, T., Nishio, E., Nonaka, T., Ogio, S., Ohoka, H., Okazaki, N., Oku, Y., Okuda, T., Omura, Y., Onishi, M., Ono, M., Oshima, A., Oshima, H., Ozawa, S., Park, I.H., Park, K.Y., Potts, M., Pshirkov, M.S., Remington, J., Rodriguez, D.C., Rott, C., Rubtsov, G.I., Ryu, D., Sagawa, H., Saito, R., Sakaki, N., Sako, T., Sakurai, N., Sato, D., Sato, K., Sato, S., Sekino, K., Shah, P.D., Shibata, N., Shibata, T., Shikita, J., Shimodaira, H., Shin, B.K., Shin, H.S., Shinto, D., Smith, J.D., Sokolsky, P., Stokes, B.T., Stroman, T.A., Takagi, Y., Takahashi, K., Takamura, M., Takeda, M., Takeishi, R., Taketa, A., Takita, M., Tameda, Y., Tanaka, K., Tanaka, M., Thomas, S.B., Thomson, G.B., Tinyakov, P., Tkachev, I., Tokuno, H., Tomida, T., Troitsky, S., Tsuda, R., Tsunesada, Y., Udo, S., Urban, F., Vaiman, I.A., Warren, D., Wong, T., Yamazaki, K., Yashiro, K., Yoshida, F., Zhezher, Y., and Zundel, Z.

Published
2023
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10. INSPIRE: Challenge of 50 kg-class satellite to open up MeV gamma-ray astronomy

Author

Kataoka, J., primary, Iwashita, R., additional, Tanaka, K., additional, Mori, R., additional, Ogasawara, S., additional, Suga, T., additional, Koshikawa, N., additional, Watanabe, K., additional, Yasuda, M., additional, Kobayashi, H., additional, Kobayashi, D., additional, Otsubo, K., additional, Ohira, A., additional, Amaki, Y., additional, Arai, Y., additional, Tashiro, K., additional, Ozeki, Y., additional, Kawaguchi, Y., additional, Yoshimura, D., additional, Yoshida, H., additional, Takahashi, K., additional, Yatsu, Y., additional, Chujo, T., additional, Nakanishi, H., additional, Onishi, M., additional, and Takeda, S., additional

Published
2024
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12. Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study)

Author

Nakamura, Y., Namikawa, K., Yoshikawa, S., Kiniwa, Y., Maekawa, T., Yamasaki, O., Isei, T., Matsushita, S., Nomura, M., Nakai, Y., Fukushima, S., Saito, S., Takenouchi, T., Tanaka, R., Kato, H., Otsuka, A., Matsuya, T., Baba, N., Nagase, K., Inozume, T., Fujimoto, N., Kuwatsuka, Y., Onishi, M., Kaneko, T., Onuma, T., Umeda, Y., Ogata, D., Takahashi, A., Otsuka, M., Teramoto, Y., and Yamazaki, N.

Published
2021
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16. Computational evaluation of flight performance of flapping-wing nano air vehicles using hierarchical coupling of nonlinear dynamic and fluid-structure interaction analyses.

Author

Rashmikant, Onishi, M., Sugikawa, K., and Ishihara, D.

Subjects
*LIFT (Aerodynamics), *FLUID-structure interaction, *PIEZOELECTRIC actuators, *AIRPLANE wings, *WING-warping (Aerodynamics), *MICROMACHINING
Abstract

This study endeavours to introduce an inventive hierarchical coupling methodology for evaluating the flight capabilities of polymer micromachined flapping-wing nano air vehicles (FWNAVs) using advanced computational tools. Furthermore, our objective is to provide a practical demonstration of FWNAVs in both tethered and airborne scenarios. These dual objectives represent the distinctive and pioneering aspects of this research. Such FWNAVs, which are insect-inspired robots, have a 2.5-dimensional structure. An FWNAV comprises a micro piezoelectric drive system and a pair of micro thin flexible wings. The drive system includes a micro transmission and a piezoelectric bimorph actuator. The flight performance of the designed FWNAV is evaluated using a hierarchical coupling approach, where the whole system is decomposed into a micro wing and a micro piezoelectric drive system. The coupling between these parts is modelled as one-way coupling and that between the micro wings and the surrounding air is modelled as strong coupling. In the one-way coupling analysis, nonlinear structural dynamic analysis is conducted for the micro piezoelectric drive system, where the dynamic response is transmitted to the micro wings via the Dirichlet boundary condition. In the strong coupling analysis, strongly coupled fluid-structure interaction analysis is conducted for the micro wings and the surrounding air to consider their strong coupling. The optimisation of flight performance is conducted using fluid-structure interaction analysis to achieve sufficient lift force to support the weight of an FWNAV. The design of a tethered and flyable FWNAV with a size of 10mm or smaller is demonstrated. This FWNAV can be easily fabricated using polymer micromachining. [ABSTRACT FROM AUTHOR]

Published
2023
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18. P183 Development of a new simple ultrasound activity score for intestinal Behçet's Disease

Author

Yaguchi, K, primary, Kunisaki, R, additional, Sato, S, additional, Izumi, M, additional, Fukuno, Y, additional, Ebina, T, additional, Matsune, Y, additional, Hama, T, additional, Onishi, M, additional, Kobayashi, K, additional, Shibui, S, additional, Toritani, K, additional, Nishida, D, additional, Matsubayashi, M, additional, Nakamori, Y, additional, Nishio, M, additional, Umezawa, S, additional, Ogashiwa, T, additional, Sasaki, T, additional, Fujii, A, additional, Kimura, H, additional, Numata, K, additional, and Maeda, S, additional

Published
2023
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19. P780 Prognosis and optimal treatment for 5-aminosalicylic acid-intolerant patients with Ulcerative Colitis

Author

Yaguchi, K, primary, Kinoshita, H, additional, Kunisaki, R, additional, Madarame, A, additional, Tatsuno, M, additional, Nishikawa, Y, additional, Hama, T, additional, Onishi, M, additional, Kobayashi, K, additional, Shibui, S, additional, Toritani, K, additional, Nishida, D, additional, Matsubayashi, M, additional, Nakamori, Y, additional, Nishio, M, additional, Umezawa, S, additional, Ogashiwa, T, additional, Sasaki, T, additional, Fujii, A, additional, Kimura, H, additional, Kato, J, additional, and Maeda, S, additional

Published
2023
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20. Cobimetinib alone and plus venetoclax with/without atezolizumab in patients with relapsed/refractory multiple myeloma

Author

Schjesvold, F. (Fredrik), Lourenco-Paiva, B. (Bruno David), Ribrag, V. (Vincent), Rodríguez-Otero, P. (Paula), San-Miguel-Izquierdo, J. (Jesús Fernando), Robak, P. (Pawel), Hansson, M. (Markus), Onishi, M. (Maika), Hamidi, H. (Habib), Malhi, V. (Vikram), Dail, M., Dail, M. (Monique), Javery, A. (Apurva), Ku, G. (Grace), and Raab, M. S. (Marc S.)

Subjects
B-cell lymphoma-2, Mitogen-activated protein kinase pathway, Immunotherapy, Biomarker, Programmed death-ligand 1, Área de Medicina Clínica y Epidemiología
Abstract

This phase IB/II trial evaluated safety and efficacy of cobimetinib alone and in novel combinations with veneto-clax with/without atezolizumab in patients with relapsed/refractory multiple myeloma. Forty-nine patients were enrolled. Cobimetinib alone and in combination with venetoclax with/without atezolizumab was determined to be safe and tolerable; anti-tumor activity was moderate overall but higher in patients with translocation t(11;14). Introduction: Mitogen-activated protein kinase pathway mutations are present in > 50% of patients with relapsed/refractory (R/R) multiple myeloma (MM). MEK inhibitors show limited single-agent activity in R/R MM; combi-nation with B-cell lymphoma-2 (BCL-2) and programmed death-ligand 1 inhibition may improve efficacy. This phase Ib/II trial (NCT03312530) evaluated safety and efficacy of cobimetinib (cobi) alone and in combination with veneto-clax (ven) with/without atezolizumab (atezo) in patients with R/R MM. Patients and Methods: Forty-nine patients were randomized 1:2:2 to cobi 60 mg/day on days 1-21 (n = 6), cobi 40 mg/day on days 1-21 + ven 800 mg/day on days 1-28 with/without atezo 840 mg on days 1 and 15 of 28-day cycles (cobi-ven, n = 22; cobi-ven-atezo, n = 21). Safety run-in cohorts evaluated cobi-ven and cobi-ven-atezo dose levels. Results: Any-grade common adverse events (AEs) with cobi, cobi-ven, and cobi-ven-atezo, respectively, included diarrhea (33.3%, 81.8%, 90.5%) and nausea (16.7%, 50.0%, 66.7%); common grade >= 3 AEs included anemia (0%, 22.7%, 23.8%), neutropenia (0%, 13.6%, 38.1%), and thrombocytopenia (0%, 18.2%, 23.8%). The overall response rate for all-comers was 0% (cobi), 27.3% (cobi-ven), and 28.6% (cobi-ven-atezo), and 0%, 50.0%, and 100%, respectively, in patients with t(11;14) + . Biomarker analysis demon-strated non-t(11;14) patient selection with NRAS /KRAS /BRAF mutation or high BCL-2/BCL-2-L1 ratio ( > 52% of the study population) could enrich for responders to the cobi-ven combination. Conclusions: Cobi-ven and cobi-ven-atezo demonstrated manageable safety with moderate activity in all-comers, and higher activity in patients with t(11;14) + MM, supporting a biomar ker-dr iven approach for ven in MM.

Published
2023

21. Fast convolution kernels on pascal GPU with high memory efficiency

Author

Qiong Chang, Onishi, M., and Maruyama, T.

Subjects
FOS: Computer and information sciences, Computer Science - Distributed, Parallel, and Cluster Computing, Distributed, Parallel, and Cluster Computing (cs.DC)
Abstract

The convolution computation is widely used in many fields, especially in CNNs. Because of the rapid growth of the training data in CNNs, GPUs have been used for the acceleration, and memory-efficient algorithms are focused because of thier high performance. In this paper, we propose two convolution kernels for single-channel convolution and multi-channel convolution respectively. Our two methods achieve high performance by hiding the access delay of the global memory efficiently, and achieving high ratio of floating point Fused Multiply-Add operations per fetched data from the global memory. In comparison to the latest Cudnn library developed by Nvidia aimed to accelerate the deep-learning computation, the average performance improvement by our research is 2.6X for the single-channel, and 1.4X for the multi-channel., 10 pages, 5 figures

Published
2022

26. High performance dispersion compensating fibre

Author

Australian Conference on Optical Fibre Technology (19th : 1994 : Melbourne, Vic.), Onishi, M, Ishiguro, Y, Koyano, Y, Nishimura, M, Kanamori, H, and Mizutani, F

Published
1994

27. High sensitivity photodetector made of amorphous selenium and diamond cold cathode

Author

Masuzawa, T., Saito, I., Onishi, M., Ebisudani, T., Koh, A.T.T., Chua, D.H.C., Yamada, T., Ogawa, S., Takakuwa, Y., Shimosawa, T., and Okano, K.

Subjects
Selenium -- Comparative analysis -- Properties, Diamond crystals -- Properties, Diamonds -- Properties, Photodetectors -- Properties -- Comparative analysis, Physics
Abstract

In the present study, high-sensitivity photodetection has been demonstrated using an amorphous selenium (a-Se) based photodetector driven by nitrogen-doped diamond cold cathode. The emission current--applied voltage characteristics are compared between different lighting conditions, and their sensitivities are evaluated in terms of nominal quantum efficiency. The estimated nominal quantum efficiency was 10-40 for visible and up to 1000 for ultraviolet, proving a successful photodetection utilizing carrier multiplication in a-Se. PACS Nos.: 73.50.Pz, 73.61.Jc, 85.45.Db. Nous demontrons ici la photo-detection de haute sensibilite, en utilisant un photo-detecteur base sur du selenium amorphe (a-Se), entraine par une cathode froide de diamant dope a l'azote. Nous comparons sous differentes conditions les caracteristiques du courant d'emission versus le voltage applique et les sensibilites sont evaluees en fonction de l'efficacite quantique nominale. L'estime de l'efficacite quantique nominale est dans la fourchette 10-40 pour le visible et monte a 1000 pour l'UV, prouvant le succes de la photo-detection utilisant la multiplication des porteurs dans a-Se. [Traduit par la Redaction], 1. Introduction Amorphous selenium (a-Se) is a promising candidate for high-sensitivity photo imaging devices, because of its low thermal noise, high spatial resolution, as well as signal enhancement because of [...]

Published
2014
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32. Evaluating Current Research Status and Identifying Most Important Future Research Themes

Author

Tatano, H., Collins, A., James, W., Kantoush, S., Li, W.i-S., Ishikawa, H., Sumi, T., Takara, K., Herath, S., Mosalam, K., Mori, J., Imamura, F., Yoshimura, R., Berryman, K., Chigira, M., Matsushi, Y., Peek, L., Samaddar, S., Onishi, M., De Groeve, T., Ono, Y., Scawthorn, C., Hochrainer-Stigler, S., Yokomatsu, M., Suzuki, K., Ayala, I., Maki, N., Hatayama, M., Tatano, H., Collins, A., James, W., Kantoush, S., Li, W.i-S., Ishikawa, H., Sumi, T., Takara, K., Herath, S., Mosalam, K., Mori, J., Imamura, F., Yoshimura, R., Berryman, K., Chigira, M., Matsushi, Y., Peek, L., Samaddar, S., Onishi, M., De Groeve, T., Ono, Y., Scawthorn, C., Hochrainer-Stigler, S., Yokomatsu, M., Suzuki, K., Ayala, I., Maki, N., and Hatayama, M.

Abstract

This chapter focuses on group discussion sessions targeting the Priority Areas of the Sendai Framework for Disaster Risk Reduction 2015–2030. Day one group discussion session efforts were on Priority Area One—Understanding Disaster Risks; and Day two emphasis was on Priority Areas 2, 3 and 4.

Published
2021

35. Element-quality-based stiffening for the pseudoelastic mesh-moving technique

Author

Department of Mechanical Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan, Ishihara, D., Goto, A., Onishi, M., Horie, T., Niho, T., Department of Mechanical Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan, Ishihara, D., Goto, A., Onishi, M., Horie, T., and Niho, T.

Abstract

type:Journal Article, In this study, element-quality-based stiffening (EQBS) was developed as a method of maintaining mesh quality in the pseudoelastic mesh-moving technique. The proposed EQBS technique increases the stiffness of the element based on two element quality parameters, the element area and shape; this differs from techniques used in previous studies. Importantly, EQBS includes the previously proposed Jacobian-based stiffening (JBS) and minimum height-based stiffening (MHBS) techniques as a specific case. Therefore, it is quite general scenario of the selective stiffening of the mesh. The proposed EQBS technique was applied to the mesh-moving of a rectangular domain including a structure consisting of a square and a fin that undergo large translations and rotations. The proposed EQBS technique showed better performance than JBS on test problems with large translations and rotations applied to the structure. This is because EQBS considers the shear deformation of the element in addition to the tensile and compressive deformations., source:https://doi.org/10.1142/S0219876218501463

Published
2020

47. Performance analyses of TES microcalorimeters with mushroom shaped X-ray absorbers made of Sn or Bi

Author

Ishisaki, Y, Morita, U, Koga, T, Shinozaki, K, Sato, K, Takai, N, Ohashi, T, Arakawa, T, Kudo, H, Sato, H, Kobayashi, H, Izumi, T, Ohtsuka, S, Mori, K, Shoji, S, Osaka, T, Homma, T, Mitsuda, K, Yamasaki, N.Y, Fujimoto, R, Iyomoto, N, Oshima, T, Futamoto, K, Takei, Y, Ichitsubo, T, Fujimori, T, Yoshida, K, Kuroda, Y, Onishi, M, Goto, M, and Beppu, F

Published
2004
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48. Fabrication of multi-pixel TES microcalorimeters with an electrodeposited Sn absorber and Bi absorber

Author

Arakawa, T., Kudo, H., Sato, H., Kobayashi, H., Izumi, T., Ohtsuka, S., Mori, K., Shoji, S., Osaka, T., Homma, T., Mitsuda, K., Yamasaki, N., Fujimoto, R., Iyomoto, N., Oshima, T., Futamoto, K., Takei, Y., Ichitsubo, T., Fujimori, T., Yoshida, K., Ishisaki, Y., Morita, U., Koga, T., Shinozaki, K., Sato, K., Takai, N., Ohashi, T., Kuroda, Y., Onishi, M., Goto, M., and Beppu, F.

Published
2004
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49. TES microcalorimeter development for future Japanese X-ray astronomy missions

Author

Fujimoto, R, Mitsuda, K, Yamasaki, N.Y, Iyomoto, N, Oshima, T, Takei, Y, Futamoto, K, Ichitsubo, T, Fujimori, T, Yoshida, K, Ishisaki, Y, Morita, U, Koga, T, Shinozaki, K, Sato, K, Takai, N, Ohashi, T, Kudo, H, Sato, H, Arakawa, T, Kobayashi, H, Izumi, T, Ohtsuka, S, Mori, K, Shoji, S, Osaka, T, Homma, T, Kuroda, Y, Onishi, M, Goto, M, Beppu, F, Tanaka, T, Morooka, T, Nakayama, S, and Chinone, K

Published
2004
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50. Prototype of the high sensitive X-ray microcalorimeter for X-ray imaging

Author

Kudo, H., Nakamura, T., Arakawa, T., Ohtsuka, S., Izumi, T., Shoji, S., Sato, H., Kobayashi, H., Mori, K., Homma, T., Osaka, T., Mitsuda, K., Yamasaki, N.Y., Fujimoto, R., Iyomoto, N., Oshima, T., Futamoto, K., Takei, Y., Ichitsubo, T., Fujimori, T., Ishisaki, Y., Morita, U., Koga, T., Sato, K., Ohashi, T., Kuroda, Y., Onishi, M., Otake, K., and Beppu, F.

Published
2004
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