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210 results on '"Onishi I"'

4. FRI0065 CLINICAL FEATURES OF METHOTREXATE ASSOCIATED LYMPHOPROLIFERATIVE DISORDER IN RHEUMATOID ARTHRITIS PATIENTS AND INFLUENCE OF CD8 POSITIVE LYMPHOCYTE INFILTRATION

Author

Kameda, T., primary, Nakashima, S., additional, Inoo, M., additional, Onishi, I., additional, Kurata, N., additional, Shimada, H., additional, Mahmoud Fahmy Mansour, M., additional, Wakiya, R., additional, Kato, M., additional, Ushio, Y., additional, Sugihara, K., additional, Miyagi, T., additional, and Dobashi, H., additional

Published
2020
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8. Prognostic Impact of Cancer Stem Cell-Like Phenotypes in Pancreatic Ductal Adenocarcinoma

Author

Yamamoto K, Masanobu Kitagawa, Jin Xh, Abe S, Yuko Kinowaki, Onishi I, Aihemaiti G, and Susumu Kirimura

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Pathology, biology, CD44, Hazard ratio, Cancer, medicine.disease, Phenotype, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cancer stem cell, 030220 oncology & carcinogenesis, Pancreatic cancer, Internal medicine, Cancer cell, biology.protein, medicine, Immunohistochemistry
Abstract

Aim: To investigate the expression of cancer stem cell-like phenotypes in invasive pancreatic ductal adenocarcinoma, we analysed the correlation between the expression status of stemness markers and minichromosome maintenance 2 (MCM2), and clinicopathological characteristics; we also evaluated the prognostic significance of cancer stem cell-like features. Methods and results: We performed immunohistochemical staining in 44 cases of invasive pancreatic ductal adenocarcinoma. Patients were classified into high-expression and low-expression groups on the basis of the expression level of CD133, CD44, ALDH1, EpCAM, and MCM2. Seventeen of the 44 cases (39%) demonstrated high expression levels of CD133, whereas 12 of the 44 cases (27%) demonstrated high expression levels of CD44; 36 of the 44 cases (81%) demonstrated high expression levels of ALDH1, and 21 of the 44 cases (47%) demonstrated high expression levels of EpCAM. MCM2 was expressed in the nuclei of cancer cells with a positive cell ratio that ranged from 10% to 70%. Frequent positive stemness markers and/or a low expression of MCM2 was significantly correlated with worse overall survival (P=0.030). We defined frequent positive stemness markers (number of highly expressed markers>3) and/or a low expression of MCM2 phenotypes as the representative pattern of a cancer stem cell-like phenotype. The cancer stem cell-like phenotype was identified as an independent factor of overall survival by univariate (P=0.03) and multivariate analysis (hazard ratio, 2.763%; 95% confidence interval, 1.121-6.813; P=0.0273). Conclusion: The cancer stem cell-like phenotype could be involved in therapeutic resistance, resulting in worse overall survival. The cancer stem cell-like phenotype can be an indicator of recurrence in cases of invasive pancreatic ductal adenocarcinoma.

Published
2016
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9. THU0209 Lymphocyte subsets in biopsy specimen are associated with spontaneous regression of lymphoproliferative disorders in rheumatoid arthritis patients treated with methotrexate

Author

Kameda, T, primary, Izumikawa, M, additional, Inoo, M, additional, Onishi, I, additional, Kurata, N, additional, Nakashima, S, additional, Shimada, H, additional, Ozaki, H, additional, Wakiya, R, additional, Kondo, A, additional, Kadowaki, N, additional, and Dobashi, H, additional

Published
2017
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10. AB0197 Evaluation of Serum IL-10 and IP-10 Levels Is Useful as Prognostic Biomarkers for Selection of IL-6R Antibody (TCZ) Prior To Tumor Necrosis Factor (TNF) Inhibitor in Rheumatoid Arthritis Treatment

Author

Kameda, T., primary, Dobashi, H., additional, Inoo, M., additional, Onishi, I., additional, Kurata, N., additional, Izumikawa, M., additional, Takeuchi, Y., additional, Nakashima, S., additional, Shimada, H., additional, Ozaki, H., additional, Wakiya, R., additional, and Kadowaki, N., additional

Published
2016
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13. Photoinduced Metal-to-Insulator Transition in a Manganite Thin Film

Author

Takubo, N., Onishi, I., Takubo, Kou, Mizokawa, T., and Miyano, K.

Subjects
Materials science, Condensed matter physics, Photoemission spectroscopy, Elastic energy, General Physics and Astronomy, Multicritical point, Manganite, Condensed Matter::Materials Science, Condensed Matter::Superconductivity, Excited state, Rectangular potential barrier, Condensed Matter::Strongly Correlated Electrons, Strongly correlated material, Thin film
Abstract

A persistent photoinduced metal-to-insulator transition has been confirmed in a manganite thin film, ${\mathrm{Pr}}_{0.55}({\mathrm{Ca}}_{0.75}{\mathrm{Sr}}_{0.25}{)}_{0.45}{\mathrm{MnO}}_{3}$, near a multicritical point by monitoring with transport measurements and x-ray photoemission spectroscopy. Together with the previously reported reverse effect, the photoinduced insulator-to-metal transition, it is found that the relative stability of the metallic and insulating phases interchanges around 80 K in the middle of a very wide hysteresis loop, which is a manifestation of the large potential barrier due to the long-range elastic energy. It is shown that photons are much more effective in overcoming the barrier via the electronically excited intermediate states than via the heat mode.

Published
2008
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14. Severe Veno-occlusive Disease/Sinusoidal Obstruction Syndrome After Deceased-donor and Living-donor Liver Transplantation

Author

Takamura, H., primary, Nakanuma, S., additional, Hayashi, H., additional, Tajima, H., additional, Kakinoki, K., additional, Kitahara, M., additional, Sakai, S., additional, Makino, I., additional, Nakagawara, H., additional, Miyashita, T., additional, Okamoto, K., additional, Nakamura, K., additional, Oyama, K., additional, Inokuchi, M., additional, Ninomiya, I., additional, Kitagawa, H., additional, Fushida, S., additional, Fujimura, T., additional, Onishi, I., additional, Kayahara, M., additional, Tani, T., additional, Arai, K., additional, Yamashita, Taro, additional, Yamashita, Tatsuya, additional, Kitamura, H., additional, Ikeda, H., additional, Kaneko, S., additional, Nakanuma, Y., additional, Matsui, O., additional, and Ohta, T., additional

Published
2014
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17. FRI0207 A phase I/II clinical trial of intra-articular administration of ARG098, an anti-FAS IGM monoclonal antibody, in knee joint synovitis of japanese patients with rheumatoid arthritis

Author

Matsubara, T., primary, Okuda, K., additional, Chiba, J., additional, Takayama, A., additional, Inoue, H., additional, Sakurai, T., additional, Wakabayashi, H., additional, Kaneko, A., additional, Sugimoto, K., additional, Yamazaki, H., additional, Takanashi, T., additional, Takasaki, Y., additional, Tamura, N., additional, Ogasawara, M., additional, Inoo, M., additional, Onishi, I., additional, Kawai, S., additional, and Nohara, R., additional

Published
2013
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