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Your search keyword '"Onishi, Miyuki"' showing total 43 results
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43 results on '"Onishi, Miyuki"'

12. Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor

Author

Yamamoto, Koichi, primary, Kakino, Akemi, additional, Takeshita, Hikari, additional, Hayashi, Norihiro, additional, Li, Lei, additional, Nakano, Atsushi, additional, Hanasaki-Yamamoto, Hiroko, additional, Fujita, Yoshiko, additional, Imaizumi, Yuki, additional, Toyama-Yokoyama, Serina, additional, Nakama, Chikako, additional, Kawai, Tatsuo, additional, Takeda, Masao, additional, Hongyo, Kazuhiro, additional, Oguro, Ryosuke, additional, Maekawa, Yoshihiro, additional, Itoh, Norihisa, additional, Takami, Yoichi, additional, Onishi, Miyuki, additional, Takeya, Yasushi, additional, Sugimoto, Ken, additional, Kamide, Kei, additional, Nakagami, Hironori, additional, Ohishi, Mitsuru, additional, Kurtz, Theodore W., additional, Sawamura, Tatsuya, additional, and Rakugi, Hiromi, additional

Published
2015
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20. –374 T/A Polymorphism inRAGEGene is Associated with Onset of Diabetes Mellitus, Atherosclerosis, and Renal Dysfunction in Patients with Hypertension

Author

Kawai, Tatsuo, primary, Kamide, Kei, additional, Ito, Norihisa, additional, Onishi, Miyuki, additional, Oguro, Ryosuke, additional, Takeya, Yasushi, additional, Tatara, Yuji, additional, Maekawa, Yoshihiro, additional, Katsuya, Tomohiro, additional, Ohishi, Mitsuru, additional, and Rakugi, Hiromi, additional

Published
2012
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26. Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography

Author

Kawai, Tatsuo, primary, Kamide, Kei, additional, Onishi, Miyuki, additional, Hongyo, Kazuhiro, additional, Yamamoto-Hanasaki, Hiroko, additional, Oguro, Ryosuke, additional, Maekawa, Yoshihiro, additional, Yamamoto, Koichi, additional, Takeya, Yasushi, additional, Sugimoto, Ken, additional, Ohishi, Mitsuru, additional, and Rakugi, Hiromi, additional

Published
2012
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27. Case report of a long-surviving Werner syndrome patient with severe aortic valve stenosis

Author

Kawai, Tatsuo, primary, Nozato, Yoichi, additional, Kamide, Kei, additional, Onishi, Miyuki, additional, Yamamoto-Hanasaki, Hiroko, additional, Tatara, Yuji, additional, Takemura, Yukihiro, additional, Yamamoto, Koichi, additional, Takeya, Yasushi, additional, Sugimoto, Ken, additional, Kusakabe, Norio, additional, Yasuda, Osamu, additional, Ohishi, Mitsuru, additional, and Rakugi, Hiromi, additional

Published
2011
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35. -374 T/A Polymorphism in RAGE Gene is Associated with Onset of Diabetes Mellitus, Atherosclerosis, and Renal Dysfunction in Patients with Hypertension.

Author

Kawai, Tatsuo, Kamide, Kei, Ito, Norihisa, Onishi, Miyuki, Oguro, Ryosuke, Takeya, Yasushi, Tatara, Yuji, Maekawa, Yoshihiro, Katsuya, Tomohiro, Ohishi, Mitsuru, and Rakugi, Hiromi

Subjects
RECEPTOR for advanced glycation end products (RAGE), GENETIC polymorphisms, DIABETES, ATHEROSCLEROSIS, KIDNEY diseases, HYPERTENSION, PATIENTS, INFLAMMATION, DISEASE prevalence
Abstract

Receptor of advanced glycation end products (RAGE) is reportedly linked with chronic inflammatory diseases due to aging or diabetes. The aim of this study was to show how −374 T/A RAGE has an impact on systemic vascular damage and renal function. The study subjects were a total of 468 essential hypertension patients from the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study cohort. We prospectively examined the association of −374 T/A RAGE with their prognoses and investigated the correlation between −374 T/A RAGE and multiple clinical parameters. Kaplan-Meier analysis did not show a significant association of −374 T/A RAGE with total mortality or the prevalence of cardiovascular events. Carriers of the A allele showed a significantly higher prevalence of diabetes mellitus (DM) and lower estimated glomerular filtration rate (eGFR) than subjects without this allele. In subjects with DM, carriers of the A allele showed a significantly lower eGFR. These significant correlations were only seen in male subjects. Carriers of the A allele of −374 T/A RAGE show an independent risk of atherosclerosis and reduced renal function in male hypertensive patients with DM. [ABSTRACT FROM AUTHOR]

Published
2013
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43. A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration.

Author

Yokoyama S, Oguro R, Yamamoto K, Akasaka H, Ito N, Kawai T, Kusunoki H, Takeya Y, Takeya-Onishi M, Yamamoto-Hanasaki H, Sugimoto K, Ikebe K, Gondo Y, Ohishi M, Kamide K, and Rakugi H

Subjects
Aged, Female, Genetic Predisposition to Disease, Genotype, Glucuronidase metabolism, Humans, Hypertension, Klotho Proteins, Male, Middle Aged, Stroke metabolism, Glucuronidase blood, Glucuronidase genetics, Polymorphism, Single Nucleotide, Stroke blood
Abstract

Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general population (age=70±1 years) to assess the association between rs650439 and plasma klotho concentration. A significant trend was observed in the elderly population where plasma klotho concentration decreased as the T alleles in rs650439 increased. Subjects with a TT genotype had lower plasma klotho concentrations than those with AT+AA genotypes. In conclusion, TT genotype of klotho SNP (rs650439) is correlated with an increased incidence of stroke in hypertensive patients, and the mechanism underlying this correlation might involve the effect of rs650439 T allele on plasma klotho concentrations.

Published
2018
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