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3. Precision Medicine in Chronic Rhinosinusitis: Where Does Allergy Fit In?

Author

Xu, Xinni, Ong, Yew Kwang, Wang, De Yun, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Traidl-Hoffmann, Claudia, editor, Zuberbier, Torsten, editor, and Werfel, Thomas, editor

Published
2022
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14. Transcriptomics of rhinovirus persistence reveals sustained expression of RIG‐I and interferon‐stimulated genes in nasal epithelial cells in vitro

Author

Ong, Hsiao Hui, primary, Andiappan, Anand Kumar, additional, Duan, Kaibo, additional, Lum, Josephine, additional, Liu, Jing, additional, Tan, Kai Sen, additional, Howland, Shanshan, additional, Lee, Bernett, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Chow, Vincent T., additional, and Wang, De‐Yun, additional

Published
2022
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15. Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral Response

Author

Gamage, Akshamal M., primary, Tan, Kai Sen, additional, Chan, Wharton O. Y., additional, Lew, Zhe Zhang Ryan, additional, Liu, Jing, additional, Tan, Chee Wah, additional, Rajagopalan, Deepa, additional, Lin, Quy Xiao Xuan, additional, Tan, Le Min, additional, Venkatesh, Prasanna Nori, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Lin, Raymond Tzer Pin, additional, Prabhakar, Shyam, additional, Wang, De Yun, additional, and Wang, Lin-Fa, additional

Published
2022
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18. Induction of IL-25 Expression in Human Nasal Polyp Epithelium by Influenza Virus Infection is Abated by Interferon-Alpha Pretreatment

Author

Hong, Haiyu, primary, Tan, Kai Sen, additional, Yan, Yan, additional, Chen, Fenghong, additional, Ong, Hsiao Hui, additional, Oo, Yukei, additional, Liu, Jing, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Sugrue, Richard, additional, Chow, Vincent T, additional, and Wang, De Yun, additional

Published
2021
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20. European Position Paper on Rhinosinusitis and Nasal Polyps 2020

Author

Fokkens, Wytske, Lund, Valerie, Hopkins, Claire, Hellings, Peter, Kern, Robert, Reitsma, Sietze, Toppila- Salmi, Sanna, Bernal-Sprekelsen, Manuel, Mullol, Joaquim, Alobid, Isam, Anselmo- Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad, von Buchwald, Christian, Cervin, Anders, Cohen, Noam, Constantinidis, Jannis, De Gabory, Ludovic, Desrosiers, Martin, Diamant, Zuzana, Douglas, Richard, Gevaert, Philippe, Hafner, Anita, Harvey, Richard, Joos, Guy, Kalogjera, Livije, Knill, Andrew, Kocks, Janwillem, Landis, Basile, Limpens, Jacqueline, Lebeer, Sarah, Lourenco, Olga, Matricardi, Paolo, Meco, Cem, O’Mahony, Liam, Philpott, Carl, Ryan, Dermot, Schlosser, Rodney, Senior, Brent, Smith, Timothy, Teeling, Thijs, Tomazic, Peter Valentin, Wang, De Yun, Wang, Dehui, Zhang, Luo, Agius, Adrian, Ahlström-Emanuelsson, Cecilia, Alabri, Rashid, Albu, Silviu, Alhabash, Saied, Aleksic, Aleksandra, Aloulah, Mohammad, Al- Qudah, Mohannad, Alsaleh, Saad, Baban, Muaid Aziz, Baudoin, Tomislav, Balvers, Tijmen, Battaglia, Paolo, Bedoya, Juan David, Beule, Achim, Bofares, Khaled, Braverman, Itzhak, Brozek-Madry, Eliza, Byaruhanga, Richard, Callejas, Claudio, Carrie, Sean, Caulley, Lisa, Chussi, Desderius, de Corso, Eugenio, Coste, Andre, El Hadi, Usama, Elfarouk, Ahmed, Eloy, Philippe, Farrokhi, Shokrollah, Felisati, Giovanni, Ferrari, Michel, Fishchuk, Roman, Grayson, Jessica, Goncalves, Paulo, Grdinic, Boris, Grgic, Velimir, Hamizan, Aneeza, Heinichen, Julio, Husain, Salina, Ing Ping, Tang, Ivaska, Justinas, Jakimovska, Frodita, Jovancevic, Ljiljana, Kakande, Emily, Kamel, Reda, Karpischenko, Sergei, Kariyawasam, Harsha, Kawauchi, Hideyuki, Kjeldsen, Anette, Klimek, Ludger, Krzeski, Antoni, Kopacheva Barsova, Gabriela, Wam Kim, Sung, Lal, Devyani, Letort, José, Lopatin, Andrey, Mahdjoubi, Abdelhak, Mesbahi, Alireza, Netkovski, Jane, Nyenbue Tshipukane, Dieudonné, Obando-Valverde, Andrés, Okano, Mitsuhiro, Onerci111, Metin, Ong, Yew Kwang, Orlandi, Richard, Otori, Nobuyoshi, Ouennoughy, Kheir, Ozkan, Muge, Peric, Aleksandar, Plzak, Jan, Prokopakis, Emmanuel, Prepageran, Nerayanan, Psaltis, Alkis, Pugin, Benoit, Raftopulos, Marco, Rombaux, Philippe, Riechelmann, Herbert, Sahtout, Semia, Sarafoleanu, Caius-Codrut, Searyoh, Kafui, Rhee, Chae-Seo, Shi, Jianbo, Shkoukani, Mahdi, Shukuryan, Arthur, Sicak, Marian, Smyth, David, Snidvongs, Kornkiat, Soklic Kosak, Tanja, Stjärne, Pär, Sutikno, Budi, Steinsvåg, Sverre, Tantilipikorn, Pongsakorn, Thanaviratananich, Sanguansak, Tran, Thuy, Urbancic, Jure, Valiulis, Arunas, Vasquez de Aparicio, Carolina, Vicheva, Dilyana, Virkkula, Paula, Vicente, Gil, Voegels, Richard, Wagenmann, Martin, Wardani, Retno, Welge-Lussen, Antje, Witterick, Ian, Wright, Erin, Zabolotniy, Dmytro, Zsolt, Bella, Zwetsloot, Casper, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, uBibliorum, Faculteit Medische Wetenschappen/UMCG, Fokkens, Wytske J., UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service d'oto-rhino-laryngologie, Ear, Nose and Throat, and AII - Inflammatory diseases

Subjects
Adult, medicine.medical_specialty, Evidence-based practice, Rhinosinusitis, MEDLINE, Therapeutics, PLACEBO-CONTROLLED TRIAL, 03 medical and health sciences, 0302 clinical medicine, Nasal Polyps, QUALITY-OF-LIFE, Diagnosis, paranasal sinus diseases, nasal polyps, therapeutics, diagnosis, asthma, prevention, control, Paranasal Sinus Diseases, Humans, Medicine, Nasal polyps, ENDOSCOPIC-SINUS-SURGERY, 3125 Otorhinolaryngology, ophthalmology, Sinusitis, Prevention and Control, Child, 030223 otorhinolaryngology, Intensive care medicine, UPPER RESPIRATORY-TRACT, TERM-FOLLOW-UP, Rhinitis, Science & Technology, business.industry, General Medicine, Guideline, Evidence-based medicine, RANDOMIZED CONTROLLED-TRIAL, medicine.disease, ACUTE MAXILLARY SINUSITIS, Asthma, 3. Good health, Integrated care, CHURG-STRAUSS-SYNDROME, Otorhinolaryngology, Acute Disease, Chronic Disease, Position paper, PRIMARY CILIARY DYSKINESIA, Human medicine, business, ALLERGIC FUNGAL RHINOSINUSITIS, Life Sciences & Biomedicine
Abstract

The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com. ispartof: RHINOLOGY vol:58 issue:Suppl S29 pages:I-+ ispartof: location:Netherlands status: published

Published
2020

22. Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

Author

Gamage, Akshamal M., primary, Tan, Kai Sen, additional, Chan, Wharton O. Y., additional, Liu, Jing, additional, Tan, Chee Wah, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Andiappan, Anand K., additional, Anderson, Danielle E., additional, Wang, De Yun, additional, and Wang, Lin-Fa, additional

Published
2020
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23. Next-Generation Allergic Rhinitis Care in Singapore: 2019 ARIA Care Pathways

Author

Liu, Xuandao, primary, Wang, De Yun, additional, Charn, Tze Choong, additional, Koh, Leslie Timothy, additional, Teo, Neville WY, additional, Ong, Yew Kwang, additional, Thong, Mark KT, additional, Bachert, Claus, additional, Pfaar, Oliver, additional, Schünemann, Holger J, additional, Bedbrook, Anna, additional, Czarlewski, Wienczyslawa, additional, and Bousquet, Jean, additional

Published
2020
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24. Differential treatment response to mepolizumab in severe eosinophilic asthma with nasal polyps

Author

Tan, Nadia Suray, primary, Ong, Yew Kwang, additional, Mukherjee, Manali, additional, Chao, Siew Shuen, additional, Tan, W.S. Daniel, additional, Liew, Mei Fong, additional, Xu, Xinni, additional, Sng, Yuansheng Melvin, additional, Wang, De Yun, additional, Wong, W.S. Fred, additional, Nair, Parameswaran, additional, Angeli, Veronique, additional, and Lim, Hui Fang, additional

Published
2020
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32. Contributors

Author

Abdellatif Bali, Anja Bernaerts, Alexandra R. Borges, Jan W. Casselman, Margaret N. Chapman, Ya-Fang Chen, Vincent Chong, Bert De Foer, Joost van Dinther, James Thomas Patrick Decourcy Hallinan, Theresa Kouo, Ong Yew Kwang, Timothy L. Larson, Marc Lemmerling, Yen-Heng Lin, Hon-Man Liu, Robert E. Morales, Erwin Offeciers, Prashant Raghavan, Osamu Sakai, Ilona M. Schmalfuss, Lubdha M. Shah, David Soon Yiew Sia, Eric Ting Yuik Sing, Chia Ghim Song, Fiona Ting, Richard H. Wiggins, Mathew L. Wong, Laura Wuyts, and Clement Yong

Published
2018

35. Role of IL-13Ra2 in modulating IL-13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa

Author

Liu, Jing, primary, Li, Ying Ying, additional, Andiappan, Anand Kumar, additional, Yan, Yan, additional, Tan, Kai Sen, additional, Ong, Hsiao Hui, additional, Thong, Kim Thye, additional, Ong, Yew Kwang, additional, Yu, Feng Gang, additional, Low, Heng Boon, additional, Zhang, Yong Liang, additional, Shi, Li, additional, and Wang, De Yun, additional

Published
2019
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36. RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications

Author

Tan, Kai Sen, primary, Andiappan, Anand Kumar, additional, Lee, Bernett, additional, Yan, Yan, additional, Liu, Jing, additional, Tang, See Aik, additional, Lum, Josephine, additional, He, Ting Ting, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Lim, Hui Fang, additional, Choi, Hyung Won, additional, Rotzschke, Olaf, additional, Chow, Vincent T, additional, and Wang, De Yun, additional

Published
2019
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38. H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium

Author

Tian, Tengfei, primary, Zi, Xiaoxue, additional, Peng, Yang, additional, Wang, Zhaoni, additional, Hong, Haiyu, additional, Yan, Yan, additional, Guan, Weijie, additional, Tan, Kai Sen, additional, Liu, Jing, additional, Ong, Hsiao Hui, additional, Kang, Xue, additional, Yu, Jieqing, additional, Ong, Yew Kwang, additional, Thong, Kim Thye, additional, Shi, Li, additional, Ye, Jing, additional, and Wang, De-Yun, additional

Published
2018
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39. Magnetic Resonance Imaging Study of the Pericranial Flap and Its Local Effects Following Endoscopic Craniofacial Resection.

Author

Xu, Xinni, Lwin, Sein, Ting, Eric, and Ong, Yew Kwang

Abstract

Objectives/hypothesis: To describe the magnetic resonance imaging (MRI) characteristics of the pericranial flap, changes in the pericranial flap thickness over time, presence of frontal sinus opacification, and presence of frontal lobe herniation into the nasal cavity.Study Design: Retrospective case series.Methods: Seventeen consecutive endoscopic craniofacial resections with pericranial flap reconstruction performed at a tertiary hospital from 2010 to 2019 were reviewed. Sixty-eight serial MRI scans were evaluated.Results: All pericranial flaps consistently featured a homogenous appearance on T1-weighted sequence and enhanced with contrast. On T2-weighted sequence, the skull base reconstruction demonstrated four layers of alternating hypo- and hyperintensity, which corresponded with the inlay synthetic graft or neodura (hypointense), loose areolar tissue (hyperintense), fibrous pericranium (hypointense), and nasal mucosa or granulation tissue (hyperintense). The mean pericranial flap thickness was 9.9 mm. In thicker flaps, the loose areolar layer contributed the bulk of the thickness. Of 13 patients who underwent three or more serial MRI scans, 11 flaps (84.6%) were stable and two (15.4%) had >50% reduction in their original thickness over time. Thirteen of 17 (76.5%) patients had frontal sinus opacification on follow-up. None developed frontal sinus mucoceles or frontal lobe herniation.Conclusions: The pericranial flap has a distinctive MRI appearance, especially on T2-weighted sequence. The thickness of the flap remains relatively stable over time for most patients even following radiotherapy. It is a sturdy flap that is able to support the frontal lobe. Frontal sinus obstruction is common, although complications from this appear to be rare.Level Of Evidence: 4 Laryngoscope, 131:E90-E97, 2021. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Novel findings in immunopathophysiology of chronic rhinosinusitis and their role in a model of precision medicine.

Author

Xu, Xinni, Ong, Yew Kwang, and Wang, De Yun

Subjects
*INDIVIDUALIZED medicine, *SINUSITIS, *NASAL polyps, *BIOMARKERS, *PATHOLOGICAL physiology, *BIOLOGICAL tags
Abstract

Our understanding of the pathophysiology of chronic rhinosinusitis (CRS) is continuously evolving. The traditional description of CRS in terms of two phenotypes based on the presence or absence of nasal polyps belies the underlying intricate immunopathophysiological processes responsible for this condition. CRS is being increasingly recognized as a disease spectrum encompassing a range of inflammatory states in the sinonasal cavity, with non‐type 2 inflammatory disease on one end, type 2 inflammatory, eosinophil‐heavy disease on the other and an overlap of both in different proportions in between. Abundance in research on the immune mechanisms of CRS has revealed various new endotypes that hold promise as biomarkers for the development of targeted therapies in severe, uncontrolled CRS. The introduction of precision medicine to manage this chronic, complex condition is a step forward in providing individualized care for all patients with CRS. In this review, the latest research on the pathophysiology of CRS with a focus on potential novel biomarkers and treatment options over the last 2 years are summarized and integrated into a suggested model of precision medicine in CRS. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Sino-orbital desmoid tumor in a pediatric patient – Case report with review of literature.

Author

Parulan, Mariel Angelou, Sundar, Gangadhara, Ong, Yew Kwang, Yeo, Tseng Tsai, Lee, Victor, and Kimpo, Miriam Santiago

Subjects
DESMOID tumors, SOFT tissue tumors, SKULL base, LITERATURE reviews, CELL tumors
Abstract

We report a case of a 2-year-old female who presented with bilateral progressive proptosis, visual loss, nasal obstruction, and breathing difficulty. Magnetic resonance imaging revealed a large sino-orbital mass that was extending to the orbital apex and skull base. An initial diagnosis of rhabdomyosarcoma was made elsewhere on the basis of the presence of round and spindle cell tumor. Subsequent biopsy with immunohistochemical staining was positive for nuclear staining with β-catenin, shifting the diagnosis to a myofibroblastic tumor, favoring desmoid-type fibromatosis. With image guidance, near complete excision of tumor was performed by a multidisciplinary team, while respecting danger zones such as the skull base and the optic nerve. Following a recurrence over 2 months, additional excision was performed with a 6-month treatment of methotrexate and vinblastine. Desmoid tumor is a rare form of soft tissue tumor uncommonly seen in the orbital area. Although benign, it is known to be recurrent and infiltrative. Few data are known and further information will aid in the management of these tumors. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Downregulation and Aberrant Localization of Forkhead Box J1 in Allergic Nasal Mucosa

Author

Peng, Yang, primary, Chen, Zhuo, additional, Guan, Wei-Jie, additional, Zhu, Zhenchao, additional, Tan, Kai Sen, additional, Hong, Haiyu, additional, Zi, Xiaoxue, additional, Zeng, Jie, additional, Li, Yixuan, additional, Ong, Yew Kwang, additional, Thong, Mark, additional, Shi, Li, additional, Yang, Qintai, additional, Qiu, Qianhui , additional, and Wang, De-Yun, additional

Published
2018
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49. In Vitro Model of Fully Differentiated Human Nasal Epithelial Cells Infected With Rhinovirus Reveals Epithelium-Initiated Immune Responses.

Author

Kai Sen Tan, Hsiao Hui Ong, Yan Yan, Jing Liu, Chunwei Li, Yew Kwang Ong, Kim Thye Thong, Hyung Won Choi, De-Yun Wang, Vincent T. Chow, Tan, Kai Sen, Ong, Hsiao Hui, Yan, Yan, Liu, Jing, Li, Chunwei, Ong, Yew Kwang, Thong, Kim Thye, Choi, Hyung Won, Wang, De-Yun, and Chow, Vincent T

Subjects
COMMON cold treatments, PATHOGENIC microorganisms, RESPIRATORY disease diagnosis, RESPIRATORY infection treatment, IMMUNE response, EPITHELIAL cells
Abstract

Human rhinoviruses (HRVs) are the commonest cause of the common cold. While HRV is less pathogenic than other respiratory viruses, it is frequently associated with exacerbation of chronic respiratory diseases such as rhinosinusitis and asthma. Nasal epithelial cells are the first sites of viral contact, immune initiation, and airway interconnectivity, but there are limited studies on HRV infection of nasal epithelial cells. Hence, we established a model of HRV infection of in vitro-differentiated human nasal epithelial cells (hNECs) derived from multiple individuals. Through HRV infection of hNECs, we found that HRV mainly targeted ciliated cells and preferentially induced type I and III interferon antiviral pathways. Quantitative polymerase chain reaction analysis of inflammatory genes suggested predominant type 1 immunity signaling and recruitment, with secreted CXCL9, IP-10, CXCL11, and RANTES as likely initiators of airway inflammatory responses. Additionally, we further explored HRV bidirectional release from the hNECs and identified 11 associated genes. Other HRV interactions were also identified through a systematic comparison with influenza A virus infection of hNECs. Overall, this in vitro hNEC HRV infection model provides a platform for repeatable and controlled studies of different individuals, thus providing novel insights into the roles of human nasal epithelium in HRV interaction and immune initiation. [ABSTRACT FROM AUTHOR]

Published
2018
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