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1. GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Author

Fejzo, M., Rocha, N., Cimino, I., Lockhart, S. M., Petry, C. J., Kay, R. G., Burling, K., Barker, P., George, A. L., Yasara, N., Premawardhena, A., Gong, S., Cook, E., Rimmington, D., Rainbow, K., Withers, D. J., Cortessis, V., Mullin, P. M., MacGibbon, K. W., Jin, E., Kam, A., Campbell, A., Polasek, O., Tzoneva, G., Gribble, F. M., Yeo, G. S. H., Lam, B. Y. H., Saudek, V., Hughes, I. A., Ong, K. K., Perry, J. R. B., Sutton Cole, A., Baumgarten, M., Welsh, P., Sattar, N., Smith, G. C. S., Charnock-Jones, D. S., Coll, A. P., Meek, C. L., Mettananda, S., Hayward, C., Mancuso, N., and O’Rahilly, S.

Published
2024
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2. MC3R links nutritional state to childhood growth and the timing of puberty

Author

Lam, B. Y. H., Williamson, A., Finer, S., Day, F. R., Tadross, J. A., Gonçalves Soares, A., Wade, K., Sweeney, P., Bedenbaugh, M. N., Porter, D. T., Melvin, A., Ellacott, K. L. J., Lippert, R. N., Buller, S., Rosmaninho-Salgado, J., Dowsett, G. K. C., Ridley, K. E., Xu, Z., Cimino, I., Rimmington, D., Rainbow, K., Duckett, K., Holmqvist, S., Khan, A., Dai, X., Bochukova, E. G., Trembath, R. C., Martin, H. C., Coll, A. P., Rowitch, D. H., Wareham, N. J., van Heel, D. A., Timpson, N., Simerly, R. B., Ong, K. K., Cone, R. D., Langenberg, C., Perry, J. R. B., Yeo, G. S., and O’Rahilly, S.

Published
2021
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4. GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Author

Fejzo, M., primary, Rocha, N., additional, Cimino, I., additional, Lockhart, S. M., additional, Petry, C. J., additional, Kay, R. G., additional, Burling, K., additional, Barker, P., additional, George, A. L., additional, Yasara, N., additional, Premawardhena, A., additional, Gong, S., additional, Cook, E., additional, Rimmington, D., additional, Rainbow, K., additional, Withers, D. J., additional, Cortessis, V., additional, Mullin, P. M., additional, MacGibbon, K. W., additional, Jin, E., additional, Kam, A., additional, Campbell, A., additional, Polasek, O., additional, Tzoneva, G., additional, Gribble, F. M., additional, Yeo, G. S. H., additional, Lam, B. Y. H., additional, Saudek, V., additional, Hughes, I. A., additional, Ong, K. K., additional, Perry, J. R. B., additional, Sutton Cole, A., additional, Baumgarten, M., additional, Welsh, P., additional, Sattar, N., additional, Smith, G. C. S., additional, Charnock-Jones, D. S., additional, Coll, A. P., additional, Meek, C. L., additional, Mettananda, S., additional, Hayward, C., additional, Mancuso, N., additional, and O’Rahilly, S., additional

Published
2023
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10. Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study

Author

Abbas, Z., Abburu, S., Abd Ghaffar, M. K., Abdelhadi, M., Abdikadir, H. R., Abdulmajid, A., Abid, H., Abid, A., Abuhussein, N., Abul, M. H., Acquaah, F., Acres, M., Adams, R., Adams, R. D., Adebayo, A. A., Adeleja, I., Adjei, H., Afzal, Z., Agarwal, V., Ahern, N., Ahmad, K., Ahmad, S., Ahmed, M., Ahmed, H., Ahmed, N., Ahmed, S., Ahmed, F., Ahn, J. S., Aidoo-Micah, G. E., Aildasani, L., Aithie, J. M., Akhtar, S., Ali, S., Ali, A., Ali, B., Ali, M., Ali, H., Alizadeh, M., Allan, C., Allen, J. L. Y., Allot, R., Al-Mousawi, A., Al-Obaedi, O., Al-Robeye, A., Amajuoyi, A., Amin, H., Amin, O., Amphlett, A. H., Anandarajah, C., Anderson, L., Anderson, L. B., Anderson, S. M., Ang, A., Angelov, S., Anilkumar, A., Anim-Addo, N., Ansari, N., Antoniou, I., Archer, C. H., Arif, T., Asbjoernsen, C. A., Ashfaq, U., Ashken, L., Ashraf, S. F., Ashraf, S., Ashton, A. J., Ashwood, J., Aslanyan, A., Asmadi, A., Assadullah, S., Atayi, A., Atraszkiewicz, B. A., Attalla, M., Austreng, L., Auyoung, E., Avery, P., Axelson, T., Aziz, H., Aziz, N., Baker, A. N., Bakewell, Z. R., Bakhsh, A., Balaji, S., Balian, V., Bamgbose, F. A., Barai, I., Barnes, J., Barrow, T. R., Barthorpe, A. E., Bartlett, J., Bartlett, R. D., Barton, E. C., Bassam, N., Bassett, J., Bassiony, S., Bath, M. F., Batho, A., Batt, E., Bazeer, H. Z., Beckett, J., Beecroft, S., Behar, N., Bell, N., Bell, L., Bell, A., Bemand, T. P., Bergara, T., Bernstein, I., Bethell, G. S., Bhanderi, S., Bhangu, A., Bhaskaran, G., Bhatt, N., Bhatti, M., Bhome, R., Bhudia, R., Bingham, G., Blege, H. K., Blessed, R., Bloomer, J., Bloomfield, T., Blore, C. D., Bolton, W., Bolton, L., Bonsu, S., Bookless, L. R., Bose, R., Botchey, S., Boulton, A. J., Boxall, N., Boyle, J., Braganza, L., Brathwaite-Shirley, C., Bravo, M., Brecher, J., Bremner, R. H., Brennan, C., Brennan, E., Brennan, K., Brent, G., Brewer, C. F., Brewster, O., Bright, M., Brown, D., Brown, E., Brown, F. S., Brown, E. J., Broyd, A., Brzyska, K., Buakuma, P., Buchan, A. M., Buckle, R. T., Bucko, A. M., Bulley, F., Bullman, L. M., Bullock, N. P., Burgess, A., Burke, J., Burke, D., Burke, E., Burney, L. J., Callan, R., Campbell, J., Canning, N., Canning, E., Cao, Y., Cardwell, A. E., Carr, L., Carr, R., Carroll, A. F., Carter, D., Carthew, L., Chamberlain, M., Chan, N., Chan, C., Chandan, N., Chapman, S. J., Charalambos, M. A., Charalambous, G., Charania, A., Charavanamuttu, V., Chaudhary, M., Chaudhry, F. I., Chaudhry, W. W., Cheema, H., Chen, J. H., Chen, X., Chen, M., Cheng, K., Chervenkoff, J., Cheskes, L., Cheung, F., Chew, L. S., Chew, L., Chhabra, A., Chhina, C., Chilima, C. P., Chillarge, G., Chilvers, N. J., Chin, H., Chin, R., Chisholm, E. G., Chitnis, A. R., Chiu, S. M., Chong, B. F., Chong, J., Choo, K. P., Chrastek, D., Chua, E. Y., Chung, A., Claireaux, H. A., Clark, I. J., Clarke, A. K., Cleere, J., Clement, K. D., Clesham, K., Coates, A., Cody, A., Cody, N., Coffey, D., Coffey, C. J., Coffin, J., Cole, S. J., Collier, H., Collins, A., Collins, D., Collinson, S., Cooper, G. E., Cooper, D., Copley, H. C., Copley, P. C., Cornish, E., Cotton, A., Coulson, R., Cox, S. E., Craig, A. R., Craig, E., Craig-McQuaide, A., Crewdson, J. A., Croall, A., Crozier, L., Cullen, C., Cullen, S., Culleton, G., Cumber, E., Cumber, E. M., Cumming, S., Cundy, O. J., Cunha, P., Curran, A., Cuthbert, G., Cymes, W., Daoub, A., Darr, S., Das, M., Datta, U., Davies, N., Davies, J., Davies, J. E., Davies, K., Davis-Hall, M., Dawar, R., Dawson, P. M., de Bernier, G. L., Deall, C., Dean, R., Dean, S., Dean, W., Dear, K., Deas, G., Debenham, R., Deekonda, P., Delport, A., Demetri, A. M., Dennis, Y. F., Dennis, R., Derbyshire, L., Devabalan, Y., Devlin, E., Dewdney, C. J., Dhanji, A., Dhar, M., Dhutia, A. J., Diaper, C., Dickson, J., Din, W., Dindyal, S., Dinsmore, L., Doan, L., Dobson, J., Dogra, T., Doherty, C., Dolaghan, M., Dolbec, K. S., Dorman, C., Drake, T. M., Drislane, C., Dube, P., Duffy, A., Duke, K., Duncumb, J. W., Dunn, C. E., Durr, A., Durrani, B., Dutt, S., Dyal, A. R., Dynes, K., Edison, M. A., Edozie, F., Egan, R. J., Egerton, C., Elangovan, V., Elf, D., Elkawafi, M., Elliott, L. E., Elseedawy, M., Empey, J., English, W., Entwisle, J. H., Eparh, K., Eragat, M., Eraifej, J., Esteve, L., Farmer, J. D., Fautz, T., Favero, N., Fawaz, A. S., Fergurson, P., Fern, J., Filby, J. J., Filipescu, T., Fitzgerald, J. E., FitzPatrick, D., Fleck, R., Fletcher, L., Fong, J., Forrest, P. R., Forte, B., Foster, N. L., Francescon, C. T., Frank, A. L., Fung, T. M. P., Gabriel, J., Gaffney, S., Galloway, E., Gandhi, K., Gardiner, N., Gardner, E., Gardner, H., Gatfield, W. A., Gauntlett, L., Gentry, S., George, D., Geraghty, J. M., Ghaffar, A., Gilbert, H., Giles, J. E., Gill, P., Gill, C. K., Girling, C., Glasbey, J. C., Glover, T. E., Goh, B., Goh, R. W., Gohil, K., Gokani, S., Gold, D., Golding, D. M., Goldsmith, T., Goodier, R., Goradia, H., Gouda, P., Gouldthrope, C., Govinden, S., Graham, C. J., Gratton, R., Gray, L., Greenhalgh, A. D., Greig, R. J., Griffin, E. J., Grossart, C. M., Grundy, L., Gulati, J., Gundogan, B., Gupta, V., Gwozdz, A. M., Siddiqui, Z. H., Hague, A., Hameed, M., Hanrahan, M., Haq, H., Harbhajan Singh, G. S., Hardie, J., Harding, F., Hardy, M. R., Harries, P., Harris, R. T., Harris, L. N., Harrison, E. M., Harrison, P. L. M., Hartley, J., Hartley, S., Harvey, J., Hassan, S., Hayat, M., Hayat, U., Hayes, J. D. B., He, A., Healy, L., Heathcote, E., Heer, R. S., Heminway, R., Henderson, I., Henderson, L. A., Henderson, C., Heneghan, H., Henson, A. D., Heppenstall-Harris, G., Herron, J., Heskin, J., Hester, E., Hewitt, C. M., Heywood, E. G., Hibberd, A., Hickling, S. L., Higgins, A., Higgs, L., Hill, A., Hindle Fisher, I., Hirani, S., Hirst, F., Hitchen, N., Ho, W., Ho, S., Hoban, K. A., Holliday, R. B. S., Holloway, C., Holmes, C., Holmes, M. J. V., Holton, P., Holyoak, H., Horne, L., Horst, C., Horth, D., Hoskins, T. C., Howells, L., Hu, L., Huang, H. C., Hudson-Phillips, S., Hughes, F., Hughes, B. A., Hughes, R. K., Hulley, K., Hung, G., Hurst, P. C., Husnoo, S. B., Hussain, N., Hussain, O., Ibrahim, I., Ibrahim, A., Ingham, R., Ingram, E., Iqbal, S., Iqbal, A., Isaac, A., Jackson, H. R., Jackson, S., Jacob, L., Jafree, D. J., Jaitley, A., Jalota, P., Jamal, N., Jathanna, N., Jawad, A. S., Jayakody, N., Jenkin, S. L., Jenvey, C., Jewell, P. D., Jhala, H., Jindal, A., Johnston, A., Johnston, J., Johnstone, M., Jordan, H. E. M., Joshi, K. R., Joshi, D., Joyce, H. L., Joyner, C., Jubainville, C. L., Jull, P., Kadicheeni, M., Kahar, A., Kalra, N., Kanabar, S., Kane, T., Karia, M., Karia, P., Karsan, R. B., Karunakaran, P., Kaushal, A., Kazmi, Z., Keane, P., Keane, C. P., Keane, N., Kee, J. Y., Keeling, R. E., Keelty, N., Keevil, H., Kelly, M., Kelly, M. E., Kelly, N., Kennedy, E. D., Kennedy, H. R., Kerai, A., Kerr, A. L., Khajuria, A., Khalid, H., Khan, T., Khan, M., Khan, S., Khan, U., Khan, A., Khangura, J., Khanijau, R., Khatri, C., Khattak, M., Khetarpal, A. A., Khokhar, H. A., Khonat, Z., Khonsari, P., Kiff, R., Kim, S., Kim, J. W., Kimani, L., King, M., Kishore, A., Kisyov, I., Kitt, H., Knight, C. L., Kong, C. Y., Kong, C., Kosasih, S. R., Koshy, R. M., Kotecha, D., Koumpa, F., Kow, K., Koysombat, K., Kreibich, A., Kretzmer, L., Kumar, A. N., Kumaran, G., Kwan, M. L., Kwang, P., Lakhani, M., Lakhani, S. M., Lakshmipathy, G., Lalor, P., Lamont, J., Lankage, C. M., Lavery, J., Lazenby, D., Ledsam, A., Lee, A. H. Y., Lee, S., Lees, D. M., Lek, C., Leong, S., Leslie, K. E., Leung, W., Lewis, T., Li, N., Li, M. M., Liew, Y., Liew, W., Lim, K., Lim, J., Lim, D., Lim, A. E., Lim, S. J., Lim, S., Lim, E., Linton, A., Liu, S., Liu, C., Livesey, A., Lo, T., Lockey, J. W., Logan, A. E., Loke, W., Long, F., Lopes, S., Lotfallah, A., Lou, C. N., Loughran, D., Loveday, J., Low, J. Y. L., Lu, Q., Lua Boon Xuan, J., de Carvalho, J. Lucas, Luhishi, A., Luk, C. Y., Lunawat, S., Lwin, K. N., Lykoudis, P. M., Lynch, A. S., Lynne, S., Lyons, R., Maamari, R., MacAskill, A., MacDonald, J., Mackin, S., Maclennan, D., Mah, J., Mahboob, S., Maheswaran, Y., Mahmood, J., Majid, S., Major, C., Malaj, M., Malik, A., Mallick, S., Malys, M. K., Manson, R., Mansoor, S., Maple, N., Marchal, S. T., Markham, R. M., Marsden, M., Marsh, A., Marshall, D. C., Martin, A. L., Martin, R., Maru, D., Mason, J. D., Masood, M., Mastan, A., Matheson, J., Matthams, J., Matthews, B. W., Matthews, J. H., Maxwell-Armstrong, C., Mazan, K., Mazumdar, E., McAleer, S., McAleer, E., McAllister, R., McAuley, D., McBride, A., McCabe, G., McCance, E., McCann, M., McClymont, L. F., McCormack, D. R., McCrann, C., McDowell, M., McEnhill, P. M., McFarlane, H., McGalliard, R. J., McGarrigle, C., McGarvie, S., Mcgenity, C., McGowan, C., McGrath, A., McGregor, R. J., McIntyre, C. J., Mckean, E., McKelvey, L. L., McKerr, C. N., McKevitt, K. L., McLaughin, C., McLean, R. C., McLure, S. W., McMenamin, M., McMullan, R., McNamee, L., McRobbie, H. D., Meek, J., Mehdi, A., Mehta, J. K., Menon, A., Mian, A., Mills, E. D., Mills, M., Mills, H., Milne, S., Minhas, M., Miranda, B. H., Mirdavoudi, V., Mirza, M., Mishra, A., Mistry, S., Mistry, B. D., Mitchell, H., Mitha, N., Mithrakumar, P., Mitrasinovic, S., Mittapalli, D., Mogan, Y. P., Mohamud, M., Mohan, M., Mohan, K., Mohite, A., Momoh, Z., Moody, N., Moon, R. D. C., Moradzadeh, J., Morgan, F., Morgan, C., Morley, R., Morris, F., Morris, S., Morrison, P., Morrison, C. J., Mortimer, A., Murkin, C., Murphy, L., Murray, S. E., Murtaza, A., Mushtaq, J., Nachiappan, R., Nadanakumaran, K., Naqib, S., Narain, A., Naran, P., Narang, Y., Narayan, P., Narramore, R., Narwani, V., Navayogaarajah, V., Naveed, H., Nayee, H., Nehikhare, I., Nelaj, S., Neo, Y. N., Neophytou, C., Nepogodiev, D., Nesargikar, P. N., Ng, K., Ng, J. C. K., Ng, G. S., Ng, J. Q., Ng, A. Y. L., Ng, S., Ng, L., Nicholls, K., Nixon, G., Norris, J. M., North, A. S., Norton, J., Ntala, C., O’Bryan, M., O’Carroll, O., O’Connell, C., O’Connor, A., O’Connor, S., O’Flynn, L. D., O’Kane, A., O’Loughlin, R. A., O’Neill, S., O’Neill, E. M., O’Reilly, D., O’Sullivan, D. A., O’Sullivan, K., Obute, R. D., Odeleye, A., Omar, A., Omara, S., Omer, H. M., Ong, K. K., Oremule, B., Osei-Kuffour, D., Osman, S., Owasil, R., Owczarek, S., Williams, R. P., Paine, H. R., Pal, S., Palkhi, E., Palmer, C., Pandey, A., Pandey, G., Paraoan, V., Park, J. H., Parker, O., Parker, J., Parkin, J., Parsons, S., Parthiban, S., Patel, P., Patel, M., Patel, T., Patel, S., Patel, N., Patel, J. B., Patel, V., Patel, B. Y., Patel, B., Patel, B. A., Patel, K., Paul, J., Pearce, J., Pearse, R. J., Peck, F. S., Perera, M., Pericleous, A., Peroos, S., Peters, M., Petra, H., Petrarca, M., Pezas, T. P., Phan, P. N., Phillips, C., Pickard, J., Pinto, R., Piquet, A., Pitts-Tucker, T., Pizzolato, A., Player, C., Ponweera, A., Poo, S. X., Pope, S., Prabhudesai, A., Prakash, E., Preece, R., Prest-Smith, J., Priestland, R., Prys-Jones, O., Ptacek, I. B., Puan, L., Punj, R., Punjabi, N., Qamar, M. A., Qureshi, S., Qureshi, U., Qureshi, A., Rabinthiran, S., Radotra, A., Rafiq, N. M., Raghuvir, V., Raghvani, T., Rajan, N., Raji, K., Raman, K. P., Ramjeeawon, N., Ramnarine, A., Rampal, R., Ramsay, N., Ramtoola, T., Rangan, T., Rangedara, A., Raphael, M., Rashid, S., Rashid, M., Rasiah, M. G., Ratnakumaran, R., Rattan, G., Ratu, S. G., Raut, P., Reakes, T., Redgrave, N. A., Reed, A., Reeder, C., Reehal, R. S., Rees, C., Reeves, T., Reid, N. B., Reid, R., Reid, K. G., Remedios, J., Rhema, I. A., Rinkoff, S., Roberts, E. J., Roberts, A. W., Roberts, H. F., Roberts, C., Robertson, K. L., Robertson, V., Robertson, D. T., Robinson, M., Robinson, C., Robson, J., Rocke, A. S., Rogers, J. E., Rogers, S., Rojoa, D., Rookes, C. W., Rosen O’Sullivan, H., Ross, T., Ross, H., Rothwell, L., Roy, C. S. D., Ruiz, E. M., Russell, G., Ryan, M., Sabine, L. M., Sagar, R., Sagmeister, M., Sahathevan, A., Sait, M. S., Sajjad, U., Salam, G. J., Sale, T., Salem, M., Salih, A. E., Salmon, D., Sanders, J. A., Sandhu, K. K., Sandhu, S., Sangal, P., Sarvanandan, T., Sarwar, S., Sasapu, K., Satterthwaite, L., Schulz, T. M., Scotcher, S. E., Seager, E., Seedat, M., Segall, E., Sellathurai, J., Selvachandran, H., Semana, A. D., Semnani, S. A., Semple, E., Seneviratne, N., Sethi, R. K., Shafi, A. M. A., Shafiq, N. M., Shah, A., Shah, J. P., Shah, R., Shah, S., Shaheen, H., Shahid, S., Shahidi, S., Shakweh, E., Shanahan, D., Sharifpour, M., Shatkar, V., Shaunak, R., Sheldon, A., Shepherd, R., Shepherd, P., Sherif, M. A., Sherliker, G. X. J., Sheth, S., Shoa, M., Shufflebotham, H., Shuker, B. A., Shukla, A., Shumon, S., Shurovi, B. N., Shuttleworth, R. H., Siddiqui, M., Sii, S., Sim, N. K., Sim, P., Sim, D., Simpson, R., Simpson, A., Singagireson, S., Singh, B., Singh, K., Singh, R., Singh, S., Sinha, Y., Sirakaya, M., Sitta, O., Slade, R., Smith, N., Smith, D. N. E., Smith, A. C. D., Sng, S., Soo, Y. H., Soon, W. C., Sorah, T., Spence, O., Spencer, T., Springford, L. R., Sreh, A., Srikantharajah, M., Sritharan, P., Stanger, S. A., Stanley, G. H., Stather, P. W., Steel, M., Stein, J., Stevens, S., Stewart, G. E., Stezaker, S., Stoddart, M. T., Stokes, S., Stone, E. J., Stott, G. D., Strange, E., Street, A. N., Sukkari, M., Sukumar, S., Suleman, Y. N., Sullivan, J. A. L., Sun, E., Sundar-Singh, M., Suresh, S., Suresh, R. S., Syeed, J. A., Sykes, M. C., Szczap, A., Tahir, M., Tahmina, A., Tai, A., Talukdar, S. S., Tan, Y. H., Tan, R., Tan, E. T., Tan, D., Tan, Y., Tan, S., Tan, E. S. M., Tay, A. Y., Tayeh, S., Tear, A. K., Telfer, R., Teng, V., Teoh, P. J., Thacoor, A., Thakker, C. E., Thakur, H., Tharakan, R. G., Tharmachandirar, T., Theodoreson, M. D., Theodoropoulou, K., Thethi, R., Thevathasan, A. A., Thirumal, V., Thomas, G., Thomas, D., Thompson, O. D., Thompson, J. D., Tilston, T. W., Toale, C., Toh, C., Toner, E., Tongo, F., Tonkins, M., Topham, C., Torlot, G. E., Torrance, H. D., Trail, M., Traynor, B. P., Trecarten, S., Trimble, A., Trist, A. J., Tsui, A. Y., Tung, L., Turaga, S., Turley, H., Turnbull, J. A., Turner, L., Turner, M., Turner, E. J. H., Turner, J., Ungcharoen, N., Uppal, E., Valli, A., Vanmali, P., Varley, R., Varma, R. K., Varma, D., Varma, N., Vaughan, R., Venn, M., Ventre, C. M., Verma, K., Verma, S., Vernon, O. K., Vithanage, N. A., Vivekanantham, S., Wadanamby, S., Waldron, R. M., Walford, R. A., Wali, A., Wall, C., Walsh, S. L., Wan, J. C., Wang, S., Wang, A., Ward, N., Ward, T., Ward, A. E., Warren, N., Warwick, H. L., Watson, N., Watson, R. P., Weaver, R., Webb, E., Weinberg, D., Wells, M., Weston, C., Wetherall, N., Whacha, C., Whatling, E. A., Whewell, H., White, A., White, C. J., White, U., Whitehurst, K., Whitham, R. D. J., Whittingham, H., Wijesekera, M., Wild, J. R. L., Wilkinson, D., Williams, M., Williams, M. R., Williams, P., Wills, J., Wilson, H. C. P., Wilson, H., Wilson, R., Wiltshire, J. J., Winarski, A., Wing, V. C., Wingfield, L. R., Winslow, F., Woin, E., Wong, V., Wong, E., Wood, A. D., Woodcock, N., Woodward, H., Woon, E., Wright, A., Wright, E. V., Wye, J., Wylam, D., Wylie, J., Wynell-Mayow, W. M., Xiao, C., Xu, G. X., Xylas, D., Yan, A., Yang, T., Yates, J. A., Yener, A., Yim, N., Yoganathan, S., Yong, C. S., Yong, N., Yousif, A., Yow, L., Yuen, R., Zegeye, M. I., Zhao, J., Ziff, O., Ziprin, P., Zuhair, M., and STARSurg Collaborative

Published
2017
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12. Genetic analyses identify widespread sex-differential participation bias

Author

Pirastu N., Cordioli M., Nandakumar P., Mignogna G., Abdellaoui A., Hollis B., Kanai M., Rajagopal V. M., Parolo P. D. B., Baya N., Carey C. E., Karjalainen J., Als T. D., Van der Zee M. D., Day F. R., Ong K. K., Agee M., Aslibekyan S., Bell R. K., Bryc K., Clark S. K., Elson S. L., Fletez-Brant K., Fontanillas P., Furlotte N. A., Gandhi P. M., Heilbron K., Hicks B., Huber K. E., Jewett E. M., Jiang Y., Kleinman A., Lin K. -H., Litterman N. K., Luff M. K., McIntyre M. H., McManus K. F., Mountain J. L., Mozaffari S. V., Noblin E. S., Northover C. A. M., O'Connell J., Petrakovitz A. A., Pitts S. J., Poznik G. D., Sathirapongsasuti J. F., Shelton J. F., Shringarpure S., Tian C., Tung J. Y., Tunney R. J., Vacic V., Wang X., Zare A., Mortensen P. B., Mors O., Werge T., Nordentoft M., Hougaard D. M., Bybjerg-Grauholm J., Baekvad-Hansen M., Morisaki T., de Geus E., Bellocco R., Okada Y., Borglum A. D., Joshi P., Auton A., Hinds D., Neale B. M., Walters R. K., Nivard M. G., Perry J. R. B., Ganna A., Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V, Parolo, P, Baya, N, Carey, C, Karjalainen, J, Als, T, Van der Zee, M, Day, F, Ong, K, Agee, M, Aslibekyan, S, Bell, R, Bryc, K, Clark, S, Elson, S, Fletez-Brant, K, Fontanillas, P, Furlotte, N, Gandhi, P, Heilbron, K, Hicks, B, Huber, K, Jewett, E, Jiang, Y, Kleinman, A, Lin, K, Litterman, N, Luff, M, Mcintyre, M, Mcmanus, K, Mountain, J, Mozaffari, S, Noblin, E, Northover, C, O'Connell, J, Petrakovitz, A, Pitts, S, Poznik, G, Sathirapongsasuti, J, Shelton, J, Shringarpure, S, Tian, C, Tung, J, Tunney, R, Vacic, V, Wang, X, Zare, A, Mortensen, P, Mors, O, Werge, T, Nordentoft, M, Hougaard, D, Bybjerg-Grauholm, J, Baekvad-Hansen, M, Morisaki, T, de Geus, E, Bellocco, R, Okada, Y, Borglum, A, Joshi, P, Auton, A, Hinds, D, Neale, B, Walters, R, Nivard, M, Perry, J, Ganna, A, Biological Psychology, APH - Personalized Medicine, APH - Mental Health, and Adult Psychiatry

Subjects
Adult, Inheritance Pattern, Male, Sex Characteristics, Inheritance Patterns, Sex Characteristic, Polymorphism, Single Nucleotide, Article, United Kingdom, Bias, Genetic Loci, Sample Size, Bia, Artifact, Biological Specimen Bank, Humans, Chromosomes, Human, Female, Artifacts, Biological Specimen Banks, Genome-Wide Association Study, Human
Abstract

Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study contrasting one subgroup versus another. For example, we showed that sex exhibits artifactual autosomal heritability in the presence of sex-differential participation bias. By performing a genome-wide association study of sex in approximately 3.3 million males and females, we identified over 158 autosomal loci spuriously associated with sex and highlighted complex traits underpinning differences in study participation between the sexes. For example, the body mass index-increasing allele at FTO was observed at higher frequency in males compared to females (odds ratio = 1.02, P = 4.4 × 10-36). Finally, we demonstrated how these biases can potentially lead to incorrect inferences in downstream analyses and propose a conceptual framework for addressing such biases. Our findings highlight a new challenge that genetic studies may face as sample sizes continue to grow.

Published
2021
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15. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Author

Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), Järvelin, M.-R. (Marjo-Riitta), Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), and Järvelin, M.-R. (Marjo-Riitta)

Abstract

We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.

Published
2022

21. Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestinal surgery

Author

Chapman, S. J., Glasbey, J., Kelly, M., Khatri, C., Nepogodiev, D., Fitzgerald, J. E. F., Bhangu, A., Harrison, E. M., Adams, R., Patel, K., Retchless, A. R., Elsaddig, M., Curtis, A. E., McMahon, R., Mittapalli, D., Ferguson, L. A., Gentry, S. V., Kong, C. Y. N., Naqvi, Z., Amin, H., Chaudhry, B., Burke, J., Henderson, I., Trecarten, S., Clements, J. M., Drake, T. M., Wild, J. R. L., Venkatesh, H., Butters, N., Ahmeidat, H., Goergen, N., Black, D., Robertson, K., Jama, G. M., McGuire, S. A., Ahl, R., Suri, T. S., Kuo, R., Fadhlillah, M., Mills, H., Mitchell, R., Goodship, J., Tan, M., Barker, T., Wright, T., Mohamad, W., Hanna, N., Laing, G., Warnock, M. W. C., Baird-Fraser, P. R., Logan, T., Young, F. M., Fane De Salis, A. C., McHugh, R., Hickson, C., Paszkiewicz, J., Anderson, L. B., Neeson, D., Mohan, M., Narang, Y., Brophy, T., Punj, R., Majumdar, S., Kauser, S., Jong, G., Palkhi, E., Finch, D., Mitchell, H., Carter, N., Viyasar, T., Sammut, T., Cook, N., Powell, M. M., Horne, S., Allen, J. L. Y., Marshall, D., McIntyre, C., S Koh, D. T., Shi, J., Reid, T., Armugam, N. P., Luck, J., Fozard, T., OʼCallaghan, J., Copley, P. C., Tilliriou, V., Aiyer, R., Yazdi, A., Wiltshire, A., Blower, E., Jewitt, C., Cheung, L. K., Fourali, S., Rahimi, Y., Velho, R., Taylor, C., Satterthwaite, L., Eze, N. V., Johnston, J. P. M., McCain, R. S., Hess, E. C. F., Thumbadoo, R. P., Turner, E. J. H., Wookey, R., Morris, R., Gasteratos, K., Heywood, E., Simpson, S. J., Rai, Z., Kazzazi, D., Ducey, J., Livesey, M. J., Finan, C., Staunton, E., Haddad, S. D., Karanjia, R., Bokobza, I., Ahmed, M., Howell, J., Grainger, C., Woo, A., McDowall, M., Bulley, F., Keating, R., Tan, B., Sng, S., Brown, C., Aidoo-Micah, G., Champsi, A., Ellis, R., Darwazeh, S., Polson, R., Chan, J. Z., Chong, B. F. H. K., Park, J. H., Kong, C. Y., Mogan, Y. P., Stevens, S., Sekhon, H. K., McIntosh, R., Ochiltree, D. W., Jamieson, P. D., Naumann, D. N., Bowley, D. M., Howell, G., Clark, T., Dear, K., James, L., Upchurch, E., Wilson, H., Hughes, M., Modayur, S. M., Datta, U., Chen, J. H. C., Williams, L. J. L., Selby, J., Prabhudesai, A., Mahomed, K., Shah, H. A., Kong, K., Chandramoorthy, S., Marshall, L., De Kauwe, C., Rana, R., Patel, J., Pezas, T., Ma, J., Stohlner, V., Kinsella, M. S., Gardiner, S. N., Smith, R. A., Glover, M., Akinfala, M., Lee, J. Z. C., Aggarwal, V., Waters, S., Atif, M., Hill, M., Ramasubramoni, A., Jaffry, Z., Sagoo, H., Jeyakumar, J., Kosasih, S., Davis, J., Stanley, G. H. M., Nijran, J., Tang, I., Mehta, K., Fillery, A., Watson, N. F., Shah, D., Naidu, S., Grewal, T. K., Singh, P., Reissis, D., Marusza, C., Pettit, W., Timbrell, S., Woods, R., Phillips, J., Vaughan, R., Dean, S., Gibby, R., Jones, T. F., Rao, R., Torrance, H. D. T., Thirumal, V., McMahon, R. K., Yap, D., Shaw, A., Claireaux, H. A., Pang, Y. L., Narramore, R., Holmes, C., Caldwell, A., Daoub, A., Bibby, L., Hague, A. G., Sykes, M. C., Morar, P., Downes, G., Shah, S., Walimohamed, S., Alsulaimi, A., Biswas, V., Gnaneswaran, B., Davies, N., Narwani, V., Hernon, J., Jumbu, A., Ilyas, M., Johal, G., Atia, F., Williams, A., Chan, C., McAnelly, S., Evans, A., Chan, K. Y., Flegg, K., Carter, S., Coley, J., Khaw, R., Jayakody, N., Jones, B., Fawcett, N., Ghali, C., Jalundhwala, K., Ariyaratnam, P., Colville, H., Walls, M., Lindsay, J., Keane, M., Ban, V. S., Kambasha, C., Sait, S., Tahir, M., Tharakan, R., Voll, J., Shiwani, H., Al-Omran, Y., Hawash, A., McCaughan, V., Shatkar, V., Gohil, K., Greenhalgh, A., Higgins, E., Moody, T., Booth, M. B., Chan, W. H., Shanthakumaran, S., Maple, N., McNish, D., Shahin, B., Nicholas, J., McDermid, R., Narayan, P., Brodie, C., Hurrey, S., Panayi, V., Turner, B., Kopala, K., Winfield, Clayton S. A., Mohamud, A., Venkatesh, A., Hosein, S., Olimpio, C., Gkiousias, V., Kilgour, J. M., Cogbill, E., Ramcham, M., Carr, G., Bannerman, A., Grundy, L., White, S., Beamish, A., Neo, Y. N., Cragg, A. R., Perkins, A., Wynn-Hebden, A., Khan, T., Ali, M., Battersby, C. L. F., Pinto, R. S., Poon, S. S., Patel, M., Patel, P., Shafi, A. M. A., Vedage, D., Ghorbhanian, S., Klimach, S., Bradley, J., de Sausmarez, E., Hayward, P., Naqib, S., Flanigan, C., Shuttleworth, R. H. A., McElvanna, K., Shelton, B., Westbrook, N., Weir, A., Webb, P., Alam, M., Bhanderi, S., Roberts, C., Al-Shakarchi, J., Lu, M., Harvey, J., Chowdhury, M. U., McGow, C., Antoniou, I., Good, D. F., Gerasimova, N., Eragat, M., Pressler, N., Santos, C. R. D., Arshad, W., Patel, H. R., Kassim, Y., Jayaratne, N., Perera, A., Chandramoorthy, L., Quan, V., Ponweera, A., Tadjkarimi, J., Moyes, L., Metcalfe, C., Napier-Hemy, T, Bull, A., Jaffer, Y., Mushtaq, J., Warren, M., Jarrar, Z., Wickenden, R., Kang, M., Holohan, G., Isbister, T., Strachan, E., Varma, R., Simpson, R., Rajasekar, N., Panayiotou, H., Walsh, E., Thacoor, A., Willson, J. M. H., Mustafa, A., Barai, I., Menon, A., Soon, W. C., Thakrar, C., McCurdie, S., Carr, E. C. F., Westwood, K. J., Wardell, H., Weinberg, D., Craig, A. R. J., Khan, F. A. S., Mulla, A., Dann, P., Saleh, M., Pignatelli, I. C., Igbagiri, K. V., Panagoulas, E. V., Tilston, T. W., Thayaparan, A. J., Navaratnam, J., Aryasomayajula, S., Joji, N., Screen, R., Quinn, C., Harrison, R., Arnaout, A., McCartan, N., Allen, W., Gabriel, R., Hartelius, C. F., Makinde, M. L., Sivasubramaniam, S., Spreadborough, P., Lobo, R., Surendran, H., Couch, L., Butters, T., Beale, K., Markiewicz, O., Kennedy, E. D., Neely, D. M., Martin, A., Al-Moasseb, Z. H., Ong, K. K., Letchumanan, S., Lam, W. L., Yapp, L., Skelly, B. L., Stallard, S., Westhuizen, P. V. D., Rafferty, A. R., Lambert, A., Tay, Y. Z., Koshnow, Z., Elamin, O., Shah, A., Kim, E., English, W., Farrell, A., Sharma, J., Rowan, Chudek. D. K., Mullan, B., Brown, R. J., McCarter, J. A., Johnston, D., Symonds, C., Gatfield, W., Messenger, D., Knox, J. D., Jani, P., Trinquet, J., Naqvi, Z. B., Hussain, K., Jaffer, A., McAleer, E., Joshi, H., Cecil, E., Lochrane, A., Woolley, T., Marriott, P., Bolton, W., Balian, V., Scott, A. J., and Tan, Y. H.

Published
2014
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26. A genome-wide association study of sex at birth in 3 million individuals reveals widespread sex-differential participation bias with potential implications for GWAS interpretation

Author

Piratsu, N., Cordioli, M., Mignogna, G., Abdellaoui, A., Nandakumar, P., Hollis, B., Kanai, M., Manikandan, V., Parolo, P. Della Briotta, Baya, N., Carey, C., Karjalainen, J., Als, T. D., Van der Zee, M. D., Day, F. R., Ong, K. K., Morisaki, T., De Geus, E., Bellocco, R., Okada, Y., Borglum, A., Joshi, P., Auton, A., Hinds, D., Neale, B., Walters, R., Nivard, M. G., Perry, J. R. B., Ganna, A., Biological Psychology, Faculty of Behavioural and Movement Sciences, APH - Mental Health, APH - Methodology, and Political Science

Published
2020

27. The trans-ancestral genomic architecture of glycemic traits

Author

Chen, J. (Ji), Spracklen, C. N. (Cassandra N.), Marenne, G. (Gaelle), Varshney, A. (Arushi), Corbin, L. J. (Laura J.), Luan, J. (Jian'an), Willems, S. M. (Sara M.), Wu, Y. (Ying), Zhang, X. (Xiaoshuai), Horikoshi, M. (Momoko), Boutin, T. S. (Thibaud S.), Magi, R. (Reedik), Waage, J. (Johannes), Li-Gao, R. (Ruifang), Chan, K. H. (Kei Hang Katie), Yao, J. (Jie), Anasanti, M. D. (Mila D.), Chu, A. Y. (Audrey Y.), Claringbould, A. (Annique), Heikkinen, J. (Jani), Hong, J. (Jaeyoung), Hottenga, J.-J. (Jouke-Jan), Huo, S. (Shaofeng), Kaakinen, M. A. (Marika A.), Louie, T. (Tin), Maerz, W. (Winfried), Moreno-Macias, H. (Hortensia), Ndungu, A. (Anne), Nelson, S. C. (Sarah C.), Nolte, I. M. (Ilja M.), North, K. E. (Kari E.), Raulerson, C. K. (Chelsea K.), Ray, D. (Debashree), Rohde, R. (Rebecca), Rybin, D. (Denis), Schurmann, C. (Claudia), Sim, X. (Xueling), Southam, L. (Lorraine), Stewart, I. D. (Isobel D.), Wang, C. A. (Carol A.), Wang, Y. (Yujie), Wu, P. (Peitao), Zhang, W. (Weihua), Ahluwalia, T. S. (Tarunveer S.), Appel, E. V. (Emil V. R.), Bielak, L. F. (Lawrence F.), Brody, J. A. (Jennifer A.), Burtt, N. P. (Noel P.), Cabrera, C. P. (Claudia P.), Cade, B. E. (Brian E.), Chai, J. F. (Jin Fang), Chai, X. (Xiaoran), Chang, L.-C. (Li-Ching), Chen, C.-H. (Chien-Hsiun), Chen, B. H. (Brian H.), Chitrala, K. N. (Kumaraswamy Naidu), Chiu, Y.-F. (Yen-Feng), de Haan, H. G. (Hugoline G.), Delgado, G. E. (Graciela E.), Demirkan, A. (Ayse), Duan, Q. (Qing), Engmann, J. (Jorgen), Fatumo, S. A. (Segun A.), Gayan, J. (Javier), Giulianini, F. (Franco), Gong, J. H. (Jung Ho), Gustafsson, S. (Stefan), Hai, Y. (Yang), Hartwig, F. P. (Fernando P.), He, J. (Jing), Heianza, Y. (Yoriko), Huang, T. (Tao), Huerta-Chagoya, A. (Alicia), Hwang, M. Y. (Mi Yeong), Jensen, R. A. (Richard A.), Kawaguchi, T. (Takahisa), Kentistou, K. A. (Katherine A.), Kim, Y. J. (Young Jin), Kleber, M. E. (Marcus E.), Kooner, I. K. (Ishminder K.), Lai, S. (Shuiqing), Lange, L. A. (Leslie A.), Langefeld, C. D. (Carl D.), Lauzon, M. (Marie), Li, M. (Man), Ligthart, S. (Symen), Liu, J. (Jun), Loh, M. (Marie), Long, J. (Jirong), Lyssenko, V. (Valeriya), Mangino, M. (Massimo), Marzi, C. (Carola), Montasser, M. E. (May E.), Nag, A. (Abhishek), Nakatochi, M. (Masahiro), Noce, D. (Damia), Noordam, R. (Raymond), Pistis, G. (Giorgio), Preuss, M. (Michael), Raffield, L. (Laura), Rasmussen-Torvik, L. J. (Laura J.), Rich, S. S. (Stephen S.), Robertson, N. R. (Neil R.), Rueedi, R. (Rico), Ryan, K. (Kathleen), Sanna, S. (Serena), Saxena, R. (Richa), Schraut, K. E. (Katharina E.), Sennblad, B. (Bengt), Setoh, K. (Kazuya), Smith, A. V. (Albert V.), Sparso, T. (Thomas), Strawbridge, R. J. (Rona J.), Takeuchi, F. (Fumihiko), Tan, J. (Jingyi), Trompet, S. (Stella), van den Akker, E. (Erik), van der Most, P. J. (Peter J.), Verweij, N. (Niek), Vogel, M. (Mandy), Wang, H. (Heming), Wang, C. (Chaolong), Wang, N. (Nan), Warren, H. R. (Helen R.), Wen, W. (Wanqing), Wilsgaard, T. (Tom), Wong, A. (Andrew), Wood, A. R. (Andrew R.), Xie, T. (Tian), Zafarmand, M. H. (Mohammad Hadi), Zhao, J.-H. (Jing-Hua), Zhao, W. (Wei), Amin, N. (Najaf), Arzumanyan, Z. (Zorayr), Astrup, A. (Arne), Bakker, S. J. (Stephan J. L.), Baldassarre, D. (Damiano), Beekman, M. (Marian), Bergman, R. N. (Richard N.), Bertoni, A. (Alain), Blueher, M. (Matthias), Bonnycastle, L. L. (Lori L.), Bornstein, S. R. (Stefan R.), Bowden, D. W. (Donald W.), Cai, Q. (Qiuyin), Campbell, A. (Archie), Campbell, H. (Harry), Chang, Y. C. (Yi Cheng), de Geus, E. J. (Eco J. C.), Dehghan, A. (Abbas), Du, S. (Shufa), Eiriksdottir, G. (Gudny), Farmaki, A. E. (Aliki Eleni), Franberg, M. (Mattias), Fuchsberger, C. (Christian), Gao, Y. (Yutang), Gjesing, A. P. (Anette P.), Goel, A. (Anuj), Han, S. (Sohee), Hartman, C. A. (Catharina A.), Herder, C. (Christian), Hicks, A. A. (Andrew A.), Hsieh, C.-H. (Chang-Hsun), Hsueh, W. A. (Willa A.), Ichihara, S. (Sahoko), Igase, M. (Michiya), Ikram, M. A. (M. Arfan), Johnson, W. C. (W. Craig), Jorgensen, M. E. (Marit E.), Joshi, P. K. (Peter K.), Kalyani, R. R. (Rita R.), Kandeel, F. R. (Fouad R.), Katsuya, T. (Tomohiro), Khor, C. C. (Chiea Chuen), Kiess, W. (Wieland), Kolcic, I. (Ivana), Kuulasmaa, T. (Teemu), Kuusisto, J. (Johanna), Lall, K. (Kristi), Lam, K. (Kelvin), Lawlor, D. A. (Deborah A.), Lee, N. R. (Nanette R.), Lemaitre, R. N. (Rozenn N.), Li, H. (Honglan), Lin, S.-Y. (Shih-Yi), Lindstrom, J. (Jaana), Linneberg, A. (Allan), Liu, J. (Jianjun), Lorenzo, C. (Carlos), Matsubara, T. (Tatsuaki), Matsuda, F. (Fumihiko), Mingrone, G. (Geltrude), Mooijaart, S. (Simon), Moon, S. (Sanghoon), Nabika, T. (Toru), Nadkarni, G. N. (Girish N.), Nadler, J. L. (Jerry L.), Nelis, M. (Mari), Neville, M. J. (Matt J.), Norris, J. M. (Jill M.), Ohyagi, Y. (Yasumasa), Peters, A. (Annette), Peyser, P. A. (Patricia A.), Polasek, O. (Ozren), Qi, Q. (Qibin), Raven, D. (Dennis), Reilly, D. F. (Dermot F.), Reiner, A. (Alex), Rivideneira, F. (Fernando), Roll, K. (Kathryn), Rudan, I. (Igor), Sabanayagam, C. (Charumathi), Sandow, K. (Kevin), Sattar, N. (Naveed), Schuermann, A. (Annette), Shi, J. (Jinxiu), Stringham, H. M. (Heather M.), Taylor, K. D. (Kent D.), Teslovich, T. M. (Tanya M.), Thuesen, B. (Betina), Timmers, P. R. (Paul R. H. J.), Tremoli, E. (Elena), Tsai, M. Y. (Michael Y.), Uitterlinden, A. (Andre), van Dam, R. M. (Rob M.), van Heemst, D. (Diana), van Hylckama Vlieg, A. (Astrid), van Vliet-Ostaptchouk, J. V. (Jana V.), Vangipurapu, J. (Jagadish), Vestergaard, H. (Henrik), Wang, T. (Tao), Willems van Dijk, K. (Ko), Zemunik, T. (Tatijana), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Aguilar-Salinas, C. A. (Carlos Alberto), Alarcon-Riquelme, M. E. (Marta E.), An, P. (Ping), Aviles-Santa, L. (Larissa), Becker, D. M. (Diane M.), Beilin, L. J. (Lawrence J.), Bergmann, S. (Sven), Bisgaard, H. (Hans), Black, C. (Corri), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boehm, B. O. (Bernhard O.), Bonnelykke, K. (Klaus), Boomsma, D. I. (D. I.), Bottinger, E. P. (Erwin P.), Buchanan, T. A. (Thomas A.), Canouil, M. (Mickael), Caulfield, M. J. (Mark J.), Chambers, J. C. (John C.), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Cheng, C.-Y. (Ching-Yu), Collins, F. S. (Francis S.), Correa, A. (Adolfo), Cucca, F. (Francesco), de Silva, H. J. (H. Janaka), Dedoussis, G. (George), Elmstahl, S. (Solve), Evans, M. K. (Michele K.), Ferrannini, E. (Ele), Ferrucci, L. (Luigi), Florez, J. C. (Jose C.), Franks, P. W. (Paul W.), Frayling, T. M. (Timothy M.), Froguel, P. (Philippe), Gigante, B. (Bruna), Goodarzi, M. O. (Mark O.), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grarup, N. (Niels), Grimsgaard, S. (Sameline), Groop, L. (Leif), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Hamsten, A. (Anders), Hansen, T. (Torben), Hayward, C. (Caroline), Heckbert, S. R. (Susan R.), Horta, B. L. (Bernardo L.), Huang, W. (Wei), Ingelsson, E. (Erik), James, P. S. (Pankow S.), Järvelin, M.-R. (Marjo-Ritta), Jonas, J. B. (Jost B.), Jukema, J. W. (J. Wouter), Kaleebu, P. (Pontiano), Kaplan, R. (Robert), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Keinanen-Kiukaanniemi, S. M. (Sirkka M.), Kim, B.-J. (Bong-Jo), Kivimaki, M. (Mika), Koistinen, H. A. (Heikki A.), Kooner, J. S. (Jaspal S.), Koerner, A. (Antje), Kovacs, P. (Peter), Kuh, D. (Diana), Kumari, M. (Meena), Kutalik, Z. (Zoltan), Laakso, M. (Markku), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Leander, K. (Karin), Li, H. (Huaixing), Lin, X. (Xu), Lind, L. (Lars), Lindgren, C. (Cecilia), Liu, S. (Simin), Loos, R. J. (Ruth J. F.), Magnusson, P. K. (Patrik K. E.), Mahajan, A. (Anubha), Metspalu, A. (Andres), Mook-Kanamori, D. O. (Dennis O.), Mori, T. A. (Trevor A.), Munroe, P. B. (Patricia B.), Njolstad, I. (Inger), O'Connell, J. R. (Jeffrey R.), Oldehinkel, A. J. (Albertine J.), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Palmer, C. N. (Colin N. A.), Palmer, N. D. (Nicholette D.), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Porteous, D. J. (David J.), Pramstaller, P. P. (Peter P.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Raffel, L. J. (Leslie J.), Rauramaa, R. (Rainer), Redline, S. (Susan), Ridker, P. M. (Paul M.), Rosendaal, F. R. (Frits R.), Saaristo, T. E. (Timo E.), Sandhu, M. (Manjinder), Saramies, J. (Jouko), Schneiderman, N. (Neil), Schwarz, P. (Peter), Scott, L. J. (Laura J.), Selvin, E. (Elizabeth), Sever, P. (Peter), Shu, X.-o. (Xiao-ou), Slagboom, P. E. (P. Eline), Small, K. S. (Kerrin S.), Smith, B. H. (Blair H.), Snieder, H. (Harold), Sofer, T. (Tamar), Sorensen, T. I. (Thorkild I. A.), Spector, T. D. (Tim D.), Stanton, A. (Alice), Steves, C. J. (Claire J.), Stumvoll, M. (Michael), Sun, L. (Liang), Tabara, Y. (Yasuharu), Tai, E. S. (E. Shyong), Timpson, N. J. (Nicholas J.), Tonjes, A. (Anke), Tuomilehto, J. (Jaakko), Tusie, T. (Teresa), Uusitupa, M. (Matti), van der Harst, P. (Pim), van Duijn, C. (Cornelia), Vitart, V. (Veronique), Vollenweider, P. (Peter), Vrijkotte, T. G. (Tanja G. M.), Wagenknecht, L. E. (Lynne E.), Walker, M. (Mark), Wang, Y. X. (Ya X.), Wareham, N. J. (Nick J.), Watanabe, R. M. (Richard M.), Watkins, H. (Hugh), Wei, W. B. (Wen B.), Wickremasinghe, A. R. (Ananda R.), Willemsen, G. (Gonneke), Wilson, J. F. (James F.), Wong, T.-Y. (Tien-Yin), Wu, J.-Y. (Jer-Yuarn), Xiang, A. H. (Anny H.), Yanek, L. R. (Lisa R.), Yengo, L. (Loic), Yokota, M. (Mitsuhiro), Zeggini, E. (Eleftheria), Zheng, W. (Wei), Zonderman, A. B. (Alan B.), Rotter, J. I. (Jerome I.), Gloyn, A. L. (Anna L.), McCarthy, M. I. (Mark I.), Dupuis, J. (Josee), Meigs, J. B. (James B.), Scott, R. A. (Robert A.), Prokopenko, I. (Inga), Leong, A. (Aaron), Liu, C.-T. (Ching-Ti), Parker, S. C. (Stephen C. J.), Mohlke, K. L. (Karen L.), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), Morris, A. P. (Andrew P.), Barroso, I. (Ines), Chen, J. (Ji), Spracklen, C. N. (Cassandra N.), Marenne, G. (Gaelle), Varshney, A. (Arushi), Corbin, L. J. (Laura J.), Luan, J. (Jian'an), Willems, S. M. (Sara M.), Wu, Y. (Ying), Zhang, X. (Xiaoshuai), Horikoshi, M. (Momoko), Boutin, T. S. (Thibaud S.), Magi, R. (Reedik), Waage, J. (Johannes), Li-Gao, R. (Ruifang), Chan, K. H. (Kei Hang Katie), Yao, J. (Jie), Anasanti, M. D. (Mila D.), Chu, A. Y. (Audrey Y.), Claringbould, A. (Annique), Heikkinen, J. (Jani), Hong, J. (Jaeyoung), Hottenga, J.-J. (Jouke-Jan), Huo, S. (Shaofeng), Kaakinen, M. A. (Marika A.), Louie, T. (Tin), Maerz, W. (Winfried), Moreno-Macias, H. (Hortensia), Ndungu, A. (Anne), Nelson, S. C. (Sarah C.), Nolte, I. M. (Ilja M.), North, K. E. (Kari E.), Raulerson, C. K. (Chelsea K.), Ray, D. (Debashree), Rohde, R. (Rebecca), Rybin, D. (Denis), Schurmann, C. (Claudia), Sim, X. (Xueling), Southam, L. (Lorraine), Stewart, I. D. (Isobel D.), Wang, C. A. (Carol A.), Wang, Y. (Yujie), Wu, P. (Peitao), Zhang, W. (Weihua), Ahluwalia, T. S. (Tarunveer S.), Appel, E. V. (Emil V. R.), Bielak, L. F. (Lawrence F.), Brody, J. A. (Jennifer A.), Burtt, N. P. (Noel P.), Cabrera, C. P. (Claudia P.), Cade, B. E. (Brian E.), Chai, J. F. (Jin Fang), Chai, X. (Xiaoran), Chang, L.-C. (Li-Ching), Chen, C.-H. (Chien-Hsiun), Chen, B. H. (Brian H.), Chitrala, K. N. (Kumaraswamy Naidu), Chiu, Y.-F. (Yen-Feng), de Haan, H. G. (Hugoline G.), Delgado, G. E. (Graciela E.), Demirkan, A. (Ayse), Duan, Q. (Qing), Engmann, J. (Jorgen), Fatumo, S. A. (Segun A.), Gayan, J. (Javier), Giulianini, F. (Franco), Gong, J. H. (Jung Ho), Gustafsson, S. (Stefan), Hai, Y. (Yang), Hartwig, F. P. (Fernando P.), He, J. (Jing), Heianza, Y. (Yoriko), Huang, T. (Tao), Huerta-Chagoya, A. (Alicia), Hwang, M. Y. (Mi Yeong), Jensen, R. A. (Richard A.), Kawaguchi, T. (Takahisa), Kentistou, K. A. (Katherine A.), Kim, Y. J. (Young Jin), Kleber, M. E. (Marcus E.), Kooner, I. K. (Ishminder K.), Lai, S. (Shuiqing), Lange, L. A. (Leslie A.), Langefeld, C. D. (Carl D.), Lauzon, M. (Marie), Li, M. (Man), Ligthart, S. (Symen), Liu, J. (Jun), Loh, M. (Marie), Long, J. (Jirong), Lyssenko, V. (Valeriya), Mangino, M. (Massimo), Marzi, C. (Carola), Montasser, M. E. (May E.), Nag, A. (Abhishek), Nakatochi, M. (Masahiro), Noce, D. (Damia), Noordam, R. (Raymond), Pistis, G. (Giorgio), Preuss, M. (Michael), Raffield, L. (Laura), Rasmussen-Torvik, L. J. (Laura J.), Rich, S. S. (Stephen S.), Robertson, N. R. (Neil R.), Rueedi, R. (Rico), Ryan, K. (Kathleen), Sanna, S. (Serena), Saxena, R. (Richa), Schraut, K. E. (Katharina E.), Sennblad, B. (Bengt), Setoh, K. (Kazuya), Smith, A. V. (Albert V.), Sparso, T. (Thomas), Strawbridge, R. J. (Rona J.), Takeuchi, F. (Fumihiko), Tan, J. (Jingyi), Trompet, S. (Stella), van den Akker, E. (Erik), van der Most, P. J. (Peter J.), Verweij, N. (Niek), Vogel, M. (Mandy), Wang, H. (Heming), Wang, C. (Chaolong), Wang, N. (Nan), Warren, H. R. (Helen R.), Wen, W. (Wanqing), Wilsgaard, T. (Tom), Wong, A. (Andrew), Wood, A. R. (Andrew R.), Xie, T. (Tian), Zafarmand, M. H. (Mohammad Hadi), Zhao, J.-H. (Jing-Hua), Zhao, W. (Wei), Amin, N. (Najaf), Arzumanyan, Z. (Zorayr), Astrup, A. (Arne), Bakker, S. J. (Stephan J. L.), Baldassarre, D. (Damiano), Beekman, M. (Marian), Bergman, R. N. (Richard N.), Bertoni, A. (Alain), Blueher, M. (Matthias), Bonnycastle, L. L. (Lori L.), Bornstein, S. R. (Stefan R.), Bowden, D. W. (Donald W.), Cai, Q. (Qiuyin), Campbell, A. (Archie), Campbell, H. (Harry), Chang, Y. C. (Yi Cheng), de Geus, E. J. (Eco J. C.), Dehghan, A. (Abbas), Du, S. (Shufa), Eiriksdottir, G. (Gudny), Farmaki, A. E. (Aliki Eleni), Franberg, M. (Mattias), Fuchsberger, C. (Christian), Gao, Y. (Yutang), Gjesing, A. P. (Anette P.), Goel, A. (Anuj), Han, S. (Sohee), Hartman, C. A. (Catharina A.), Herder, C. (Christian), Hicks, A. A. (Andrew A.), Hsieh, C.-H. (Chang-Hsun), Hsueh, W. A. (Willa A.), Ichihara, S. (Sahoko), Igase, M. (Michiya), Ikram, M. A. (M. Arfan), Johnson, W. C. (W. Craig), Jorgensen, M. E. (Marit E.), Joshi, P. K. (Peter K.), Kalyani, R. R. (Rita R.), Kandeel, F. R. (Fouad R.), Katsuya, T. (Tomohiro), Khor, C. C. (Chiea Chuen), Kiess, W. (Wieland), Kolcic, I. (Ivana), Kuulasmaa, T. (Teemu), Kuusisto, J. (Johanna), Lall, K. (Kristi), Lam, K. (Kelvin), Lawlor, D. A. (Deborah A.), Lee, N. R. (Nanette R.), Lemaitre, R. N. (Rozenn N.), Li, H. (Honglan), Lin, S.-Y. (Shih-Yi), Lindstrom, J. (Jaana), Linneberg, A. (Allan), Liu, J. (Jianjun), Lorenzo, C. (Carlos), Matsubara, T. (Tatsuaki), Matsuda, F. (Fumihiko), Mingrone, G. (Geltrude), Mooijaart, S. (Simon), Moon, S. (Sanghoon), Nabika, T. (Toru), Nadkarni, G. N. (Girish N.), Nadler, J. L. (Jerry L.), Nelis, M. (Mari), Neville, M. J. (Matt J.), Norris, J. M. (Jill M.), Ohyagi, Y. (Yasumasa), Peters, A. (Annette), Peyser, P. A. (Patricia A.), Polasek, O. (Ozren), Qi, Q. (Qibin), Raven, D. (Dennis), Reilly, D. F. (Dermot F.), Reiner, A. (Alex), Rivideneira, F. (Fernando), Roll, K. (Kathryn), Rudan, I. (Igor), Sabanayagam, C. (Charumathi), Sandow, K. (Kevin), Sattar, N. (Naveed), Schuermann, A. (Annette), Shi, J. (Jinxiu), Stringham, H. M. (Heather M.), Taylor, K. D. (Kent D.), Teslovich, T. M. (Tanya M.), Thuesen, B. (Betina), Timmers, P. R. (Paul R. H. J.), Tremoli, E. (Elena), Tsai, M. Y. (Michael Y.), Uitterlinden, A. (Andre), van Dam, R. M. (Rob M.), van Heemst, D. (Diana), van Hylckama Vlieg, A. (Astrid), van Vliet-Ostaptchouk, J. V. (Jana V.), Vangipurapu, J. (Jagadish), Vestergaard, H. (Henrik), Wang, T. (Tao), Willems van Dijk, K. (Ko), Zemunik, T. (Tatijana), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Aguilar-Salinas, C. A. (Carlos Alberto), Alarcon-Riquelme, M. E. (Marta E.), An, P. (Ping), Aviles-Santa, L. (Larissa), Becker, D. M. (Diane M.), Beilin, L. J. (Lawrence J.), Bergmann, S. (Sven), Bisgaard, H. (Hans), Black, C. (Corri), Boehnke, M. (Michael), Boerwinkle, E. (Eric), Boehm, B. O. (Bernhard O.), Bonnelykke, K. (Klaus), Boomsma, D. I. (D. I.), Bottinger, E. P. (Erwin P.), Buchanan, T. A. (Thomas A.), Canouil, M. (Mickael), Caulfield, M. J. (Mark J.), Chambers, J. C. (John C.), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Cheng, C.-Y. (Ching-Yu), Collins, F. S. (Francis S.), Correa, A. (Adolfo), Cucca, F. (Francesco), de Silva, H. J. (H. Janaka), Dedoussis, G. (George), Elmstahl, S. (Solve), Evans, M. K. (Michele K.), Ferrannini, E. (Ele), Ferrucci, L. (Luigi), Florez, J. C. (Jose C.), Franks, P. W. (Paul W.), Frayling, T. M. (Timothy M.), Froguel, P. (Philippe), Gigante, B. (Bruna), Goodarzi, M. O. (Mark O.), Gordon-Larsen, P. (Penny), Grallert, H. (Harald), Grarup, N. (Niels), Grimsgaard, S. (Sameline), Groop, L. (Leif), Gudnason, V. (Vilmundur), Guo, X. (Xiuqing), Hamsten, A. (Anders), Hansen, T. (Torben), Hayward, C. (Caroline), Heckbert, S. R. (Susan R.), Horta, B. L. (Bernardo L.), Huang, W. (Wei), Ingelsson, E. (Erik), James, P. S. (Pankow S.), Järvelin, M.-R. (Marjo-Ritta), Jonas, J. B. (Jost B.), Jukema, J. W. (J. Wouter), Kaleebu, P. (Pontiano), Kaplan, R. (Robert), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Keinanen-Kiukaanniemi, S. M. (Sirkka M.), Kim, B.-J. (Bong-Jo), Kivimaki, M. (Mika), Koistinen, H. A. (Heikki A.), Kooner, J. S. (Jaspal S.), Koerner, A. (Antje), Kovacs, P. (Peter), Kuh, D. (Diana), Kumari, M. (Meena), Kutalik, Z. (Zoltan), Laakso, M. (Markku), Lakka, T. A. (Timo A.), Launer, L. J. (Lenore J.), Leander, K. (Karin), Li, H. (Huaixing), Lin, X. (Xu), Lind, L. (Lars), Lindgren, C. (Cecilia), Liu, S. (Simin), Loos, R. J. (Ruth J. F.), Magnusson, P. K. (Patrik K. E.), Mahajan, A. (Anubha), Metspalu, A. (Andres), Mook-Kanamori, D. O. (Dennis O.), Mori, T. A. (Trevor A.), Munroe, P. B. (Patricia B.), Njolstad, I. (Inger), O'Connell, J. R. (Jeffrey R.), Oldehinkel, A. J. (Albertine J.), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Palmer, C. N. (Colin N. A.), Palmer, N. D. (Nicholette D.), Pedersen, O. (Oluf), Pennell, C. E. (Craig E.), Porteous, D. J. (David J.), Pramstaller, P. P. (Peter P.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Raffel, L. J. (Leslie J.), Rauramaa, R. (Rainer), Redline, S. (Susan), Ridker, P. M. (Paul M.), Rosendaal, F. R. (Frits R.), Saaristo, T. E. (Timo E.), Sandhu, M. (Manjinder), Saramies, J. (Jouko), Schneiderman, N. (Neil), Schwarz, P. (Peter), Scott, L. J. (Laura J.), Selvin, E. (Elizabeth), Sever, P. (Peter), Shu, X.-o. (Xiao-ou), Slagboom, P. E. (P. Eline), Small, K. S. (Kerrin S.), Smith, B. H. (Blair H.), Snieder, H. (Harold), Sofer, T. (Tamar), Sorensen, T. I. (Thorkild I. A.), Spector, T. D. (Tim D.), Stanton, A. (Alice), Steves, C. J. (Claire J.), Stumvoll, M. (Michael), Sun, L. (Liang), Tabara, Y. (Yasuharu), Tai, E. S. (E. Shyong), Timpson, N. J. (Nicholas J.), Tonjes, A. (Anke), Tuomilehto, J. (Jaakko), Tusie, T. (Teresa), Uusitupa, M. (Matti), van der Harst, P. (Pim), van Duijn, C. (Cornelia), Vitart, V. (Veronique), Vollenweider, P. (Peter), Vrijkotte, T. G. (Tanja G. M.), Wagenknecht, L. E. (Lynne E.), Walker, M. (Mark), Wang, Y. X. (Ya X.), Wareham, N. J. (Nick J.), Watanabe, R. M. (Richard M.), Watkins, H. (Hugh), Wei, W. B. (Wen B.), Wickremasinghe, A. R. (Ananda R.), Willemsen, G. (Gonneke), Wilson, J. F. (James F.), Wong, T.-Y. (Tien-Yin), Wu, J.-Y. (Jer-Yuarn), Xiang, A. H. (Anny H.), Yanek, L. R. (Lisa R.), Yengo, L. (Loic), Yokota, M. (Mitsuhiro), Zeggini, E. (Eleftheria), Zheng, W. (Wei), Zonderman, A. B. (Alan B.), Rotter, J. I. (Jerome I.), Gloyn, A. L. (Anna L.), McCarthy, M. I. (Mark I.), Dupuis, J. (Josee), Meigs, J. B. (James B.), Scott, R. A. (Robert A.), Prokopenko, I. (Inga), Leong, A. (Aaron), Liu, C.-T. (Ching-Ti), Parker, S. C. (Stephen C. J.), Mohlke, K. L. (Karen L.), Langenberg, C. (Claudia), Wheeler, E. (Eleanor), Morris, A. P. (Andrew P.), and Barroso, I. (Ines)

Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021

28. The trans-ancestral genomic architecture of glycemic traits

Author

Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J. -J., Huo, S., Kaakinen, M. A., Louie, T., Marz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D., Wang, C. A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S., Appel, E. V. R., Bielak, L. F., Brody, J. A., Burtt, N. P., Cabrera, C. P., Cade, B. E., Chai, J. F., Chai, X., Chang, L. -C., Chen, C. -H., Chen, B. H., Chitrala, K. N., Chiu, Y. -F., de Haan, H. G., Delgado, G. E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S. A., Gayan, J., Giulianini, F., Gong, J. H., Gustafsson, S., Hai, Y., Hartwig, F. P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M. Y., Jensen, R. A., Kawaguchi, T., Kentistou, K. A., Kim, Y. J., Kleber, M. E., Kooner, I. K., Lai, S., Lange, L. A., Langefeld, C. D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M. E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L. J., Rich, S. S., Robertson, N. R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K. E., Sennblad, B., Setoh, K., Smith, A. V., Sparso, T., Strawbridge, R. J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P. J., Verweij, N., Vogel, M., Wang, H., Wang, Chin Heng, Wang, N., Warren, H. R., Wen, W., Wilsgaard, T., Wong, A., Wood, A. R., Xie, T., Zafarmand, M. H., Zhao, J. -H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S. J. L., Baldassarre, D., Beekman, M., Bergman, R. N., Bertoni, Anna Marta Maria, Bluher, M., Bonnycastle, L. L., Bornstein, S. R., Bowden, D. W., Cai, Q., Campbell, A., Campbell, H., Chang, Y. C., de Geus, E. J. C., Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A. E., Franberg, M., Fuchsberger, C., Gao, Y., Gjesing, A. P., Goel, A., Han, S., Hartman, C. A., Herder, C., Hicks, A. A., Hsieh, C. -H., Hsueh, W. A., Ichihara, S., Igase, M., Ikram, M. A., Johnson, W. C., Jorgensen, M. E., Joshi, P. K., Kalyani, R. R., Kandeel, F. R., Katsuya, T., Khor, C. C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Lall, K., Lam, K., Lawlor, D. A., Lee, N. R., Lemaitre, R. N., Li, H., Lin, S. -Y., Lindstrom, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, Geltrude, Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G. N., Nadler, J. L., Nelis, M., Neville, M. J., Norris, J. M., Ohyagi, Y., Peters, A., Peyser, P. A., Polasek, O., Qi, Q., Raven, D., Reilly, D. F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schurmann, A., Shi, J., Stringham, H. M., Taylor, K. D., Teslovich, T. M., Thuesen, B., Timmers, P. R. H. J., Tremoli, Elena, Tsai, M. Y., Uitterlinden, A., van Dam, R. M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J. V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G. R., Adair, L. S., Aguilar-Salinas, C. A., Alarcon-Riquelme, M. E., An, P., Aviles-Santa, L., Becker, D. M., Beilin, L. J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Bohm, B. O., Bonnelykke, K., Boomsma, D. I., Bottinger, E. P., Buchanan, T. A., Canouil, M., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Cheng, C. -Y., Collins, F. S., Correa, A., Cucca, F., de Silva, H. J., Dedoussis, G., Elmstahl, S., Evans, M. K., Ferrannini, E., Ferrucci, L., Florez, J. C., Franks, P. W., Frayling, T. M., Froguel, P., Gigante, B., Goodarzi, M. O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S. R., Horta, B. L., Huang, W., Ingelsson, E., James, P. S., Jarvelin, M. -R., Jonas, J. B., Jukema, J. W., Kaleebu, P., Kaplan, R., Kardia, S. L. R., Kato, N., Keinanen-Kiukaanniemi, S. M., Kim, B. -J., Kivimaki, M., Koistinen, H. A., Kooner, J. S., Korner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T. A., Launer, L. J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, R. J. F., Magnusson, P. K. E., Mahajan, A., Metspalu, A., Mook-Kanamori, D. O., Mori, T. A., Munroe, P. B., Njolstad, I., O'Connell, J. R., Oldehinkel, A. J., Ong, K. K., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pedersen, O., Pennell, C. E., Porteous, D. J., Pramstaller, P. P., Province, M. A., Psaty, B. M., Qi, L., Raffel, L. J., Rauramaa, R., Redline, S., Ridker, P. M., Rosendaal, F. R., Saaristo, T. E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L. J., Selvin, E., Sever, P., Shu, X. -O., Slagboom, P. E., Small, K. S., Smith, B. H., Snieder, H., Sofer, T., Sorensen, T. I. A., Spector, T. D., Stanton, A., Steves, C. J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E. S., Timpson, N. J., Tonjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, T. G. M., Wagenknecht, L. E., Walker, M., Wang, Y. X., Wareham, N. J., Watanabe, R. M., Watkins, H., Wei, W. B., Wickremasinghe, A. R., Willemsen, G., Wilson, J. F., Wong, T. -Y., Wu, J. -Y., Xiang, A. H., Yanek, L. R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A. B., Rotter, J. I., Gloyn, A. L., Mccarthy, M. I., Dupuis, J., Meigs, J. B., Scott, R. A., Prokopenko, I., Leong, A., Liu, C. -T., Parker, S. C. J., Mohlke, K. L., Langenberg, C., Wheeler, E., Morris, A. P., Barroso, I., van Willems van Dijk, K., Wang C., Bertoni A. (ORCID:0000-0001-7228-8718), Mingrone G. (ORCID:0000-0003-2021-528X), Tremoli E., Chen, J., Spracklen, C. N., Marenne, G., Varshney, A., Corbin, L. J., Luan, J., Willems, S. M., Wu, Y., Zhang, X., Horikoshi, M., Boutin, T. S., Magi, R., Waage, J., Li-Gao, R., Chan, K. H. K., Yao, J., Anasanti, M. D., Chu, A. Y., Claringbould, A., Heikkinen, J., Hong, J., Hottenga, J. -J., Huo, S., Kaakinen, M. A., Louie, T., Marz, W., Moreno-Macias, H., Ndungu, A., Nelson, S. C., Nolte, I. M., North, K. E., Raulerson, C. K., Ray, D., Rohde, R., Rybin, D., Schurmann, C., Sim, X., Southam, L., Stewart, I. D., Wang, C. A., Wang, Y., Wu, P., Zhang, W., Ahluwalia, T. S., Appel, E. V. R., Bielak, L. F., Brody, J. A., Burtt, N. P., Cabrera, C. P., Cade, B. E., Chai, J. F., Chai, X., Chang, L. -C., Chen, C. -H., Chen, B. H., Chitrala, K. N., Chiu, Y. -F., de Haan, H. G., Delgado, G. E., Demirkan, A., Duan, Q., Engmann, J., Fatumo, S. A., Gayan, J., Giulianini, F., Gong, J. H., Gustafsson, S., Hai, Y., Hartwig, F. P., He, J., Heianza, Y., Huang, T., Huerta-Chagoya, A., Hwang, M. Y., Jensen, R. A., Kawaguchi, T., Kentistou, K. A., Kim, Y. J., Kleber, M. E., Kooner, I. K., Lai, S., Lange, L. A., Langefeld, C. D., Lauzon, M., Li, M., Ligthart, S., Liu, J., Loh, M., Long, J., Lyssenko, V., Mangino, M., Marzi, C., Montasser, M. E., Nag, A., Nakatochi, M., Noce, D., Noordam, R., Pistis, G., Preuss, M., Raffield, L., Rasmussen-Torvik, L. J., Rich, S. S., Robertson, N. R., Rueedi, R., Ryan, K., Sanna, S., Saxena, R., Schraut, K. E., Sennblad, B., Setoh, K., Smith, A. V., Sparso, T., Strawbridge, R. J., Takeuchi, F., Tan, J., Trompet, S., van den Akker, E., van der Most, P. J., Verweij, N., Vogel, M., Wang, H., Wang, Chin Heng, Wang, N., Warren, H. R., Wen, W., Wilsgaard, T., Wong, A., Wood, A. R., Xie, T., Zafarmand, M. H., Zhao, J. -H., Zhao, W., Amin, N., Arzumanyan, Z., Astrup, A., Bakker, S. J. L., Baldassarre, D., Beekman, M., Bergman, R. N., Bertoni, Anna Marta Maria, Bluher, M., Bonnycastle, L. L., Bornstein, S. R., Bowden, D. W., Cai, Q., Campbell, A., Campbell, H., Chang, Y. C., de Geus, E. J. C., Dehghan, A., Du, S., Eiriksdottir, G., Farmaki, A. E., Franberg, M., Fuchsberger, C., Gao, Y., Gjesing, A. P., Goel, A., Han, S., Hartman, C. A., Herder, C., Hicks, A. A., Hsieh, C. -H., Hsueh, W. A., Ichihara, S., Igase, M., Ikram, M. A., Johnson, W. C., Jorgensen, M. E., Joshi, P. K., Kalyani, R. R., Kandeel, F. R., Katsuya, T., Khor, C. C., Kiess, W., Kolcic, I., Kuulasmaa, T., Kuusisto, J., Lall, K., Lam, K., Lawlor, D. A., Lee, N. R., Lemaitre, R. N., Li, H., Lin, S. -Y., Lindstrom, J., Linneberg, A., Lorenzo, C., Matsubara, T., Matsuda, F., Mingrone, Geltrude, Mooijaart, S., Moon, S., Nabika, T., Nadkarni, G. N., Nadler, J. L., Nelis, M., Neville, M. J., Norris, J. M., Ohyagi, Y., Peters, A., Peyser, P. A., Polasek, O., Qi, Q., Raven, D., Reilly, D. F., Reiner, A., Rivideneira, F., Roll, K., Rudan, I., Sabanayagam, C., Sandow, K., Sattar, N., Schurmann, A., Shi, J., Stringham, H. M., Taylor, K. D., Teslovich, T. M., Thuesen, B., Timmers, P. R. H. J., Tremoli, Elena, Tsai, M. Y., Uitterlinden, A., van Dam, R. M., van Heemst, D., van Hylckama Vlieg, A., van Vliet-Ostaptchouk, J. V., Vangipurapu, J., Vestergaard, H., Wang, T., Willems van Dijk, K., Zemunik, T., Abecasis, G. R., Adair, L. S., Aguilar-Salinas, C. A., Alarcon-Riquelme, M. E., An, P., Aviles-Santa, L., Becker, D. M., Beilin, L. J., Bergmann, S., Bisgaard, H., Black, C., Boehnke, M., Boerwinkle, E., Bohm, B. O., Bonnelykke, K., Boomsma, D. I., Bottinger, E. P., Buchanan, T. A., Canouil, M., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. -D. I., Cheng, C. -Y., Collins, F. S., Correa, A., Cucca, F., de Silva, H. J., Dedoussis, G., Elmstahl, S., Evans, M. K., Ferrannini, E., Ferrucci, L., Florez, J. C., Franks, P. W., Frayling, T. M., Froguel, P., Gigante, B., Goodarzi, M. O., Gordon-Larsen, P., Grallert, H., Grarup, N., Grimsgaard, S., Groop, L., Gudnason, V., Guo, X., Hamsten, A., Hansen, T., Hayward, C., Heckbert, S. R., Horta, B. L., Huang, W., Ingelsson, E., James, P. S., Jarvelin, M. -R., Jonas, J. B., Jukema, J. W., Kaleebu, P., Kaplan, R., Kardia, S. L. R., Kato, N., Keinanen-Kiukaanniemi, S. M., Kim, B. -J., Kivimaki, M., Koistinen, H. A., Kooner, J. S., Korner, A., Kovacs, P., Kuh, D., Kumari, M., Kutalik, Z., Laakso, M., Lakka, T. A., Launer, L. J., Leander, K., Lin, X., Lind, L., Lindgren, C., Liu, S., Loos, R. J. F., Magnusson, P. K. E., Mahajan, A., Metspalu, A., Mook-Kanamori, D. O., Mori, T. A., Munroe, P. B., Njolstad, I., O'Connell, J. R., Oldehinkel, A. J., Ong, K. K., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pedersen, O., Pennell, C. E., Porteous, D. J., Pramstaller, P. P., Province, M. A., Psaty, B. M., Qi, L., Raffel, L. J., Rauramaa, R., Redline, S., Ridker, P. M., Rosendaal, F. R., Saaristo, T. E., Sandhu, M., Saramies, J., Schneiderman, N., Schwarz, P., Scott, L. J., Selvin, E., Sever, P., Shu, X. -O., Slagboom, P. E., Small, K. S., Smith, B. H., Snieder, H., Sofer, T., Sorensen, T. I. A., Spector, T. D., Stanton, A., Steves, C. J., Stumvoll, M., Sun, L., Tabara, Y., Tai, E. S., Timpson, N. J., Tonjes, A., Tuomilehto, J., Tusie, T., Uusitupa, M., van der Harst, P., van Duijn, C., Vitart, V., Vollenweider, P., Vrijkotte, T. G. M., Wagenknecht, L. E., Walker, M., Wang, Y. X., Wareham, N. J., Watanabe, R. M., Watkins, H., Wei, W. B., Wickremasinghe, A. R., Willemsen, G., Wilson, J. F., Wong, T. -Y., Wu, J. -Y., Xiang, A. H., Yanek, L. R., Yengo, L., Yokota, M., Zeggini, E., Zheng, W., Zonderman, A. B., Rotter, J. I., Gloyn, A. L., Mccarthy, M. I., Dupuis, J., Meigs, J. B., Scott, R. A., Prokopenko, I., Leong, A., Liu, C. -T., Parker, S. C. J., Mohlke, K. L., Langenberg, C., Wheeler, E., Morris, A. P., Barroso, I., van Willems van Dijk, K., Wang C., Bertoni A. (ORCID:0000-0001-7228-8718), Mingrone G. (ORCID:0000-0003-2021-528X), and Tremoli E.

Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.

Published
2021

29. Genetic analyses identify widespread sex-differential participation bias

Author

Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V, Parolo, P, Baya, N, Carey, C, Karjalainen, J, Als, T, Van der Zee, M, Day, F, Ong, K, Agee, M, Aslibekyan, S, Bell, R, Bryc, K, Clark, S, Elson, S, Fletez-Brant, K, Fontanillas, P, Furlotte, N, Gandhi, P, Heilbron, K, Hicks, B, Huber, K, Jewett, E, Jiang, Y, Kleinman, A, Lin, K, Litterman, N, Luff, M, Mcintyre, M, Mcmanus, K, Mountain, J, Mozaffari, S, Noblin, E, Northover, C, O'Connell, J, Petrakovitz, A, Pitts, S, Poznik, G, Sathirapongsasuti, J, Shelton, J, Shringarpure, S, Tian, C, Tung, J, Tunney, R, Vacic, V, Wang, X, Zare, A, Mortensen, P, Mors, O, Werge, T, Nordentoft, M, Hougaard, D, Bybjerg-Grauholm, J, Baekvad-Hansen, M, Morisaki, T, de Geus, E, Bellocco, R, Okada, Y, Borglum, A, Joshi, P, Auton, A, Hinds, D, Neale, B, Walters, R, Nivard, M, Perry, J, Ganna, A, Pirastu N., Cordioli M., Nandakumar P., Mignogna G., Abdellaoui A., Hollis B., Kanai M., Rajagopal V. M., Parolo P. D. B., Baya N., Carey C. E., Karjalainen J., Als T. D., Van der Zee M. D., Day F. R., Ong K. K., Agee M., Aslibekyan S., Bell R. K., Bryc K., Clark S. K., Elson S. L., Fletez-Brant K., Fontanillas P., Furlotte N. A., Gandhi P. M., Heilbron K., Hicks B., Huber K. E., Jewett E. M., Jiang Y., Kleinman A., Lin K. -H., Litterman N. K., Luff M. K., McIntyre M. H., McManus K. F., Mountain J. L., Mozaffari S. V., Noblin E. S., Northover C. A. M., O'Connell J., Petrakovitz A. A., Pitts S. J., Poznik G. D., Sathirapongsasuti J. F., Shelton J. F., Shringarpure S., Tian C., Tung J. Y., Tunney R. J., Vacic V., Wang X., Zare A., Mortensen P. B., Mors O., Werge T., Nordentoft M., Hougaard D. M., Bybjerg-Grauholm J., Baekvad-Hansen M., Morisaki T., de Geus E., Bellocco R., Okada Y., Borglum A. D., Joshi P., Auton A., Hinds D., Neale B. M., Walters R. K., Nivard M. G., Perry J. R. B., Ganna A., Pirastu, N, Cordioli, M, Nandakumar, P, Mignogna, G, Abdellaoui, A, Hollis, B, Kanai, M, Rajagopal, V, Parolo, P, Baya, N, Carey, C, Karjalainen, J, Als, T, Van der Zee, M, Day, F, Ong, K, Agee, M, Aslibekyan, S, Bell, R, Bryc, K, Clark, S, Elson, S, Fletez-Brant, K, Fontanillas, P, Furlotte, N, Gandhi, P, Heilbron, K, Hicks, B, Huber, K, Jewett, E, Jiang, Y, Kleinman, A, Lin, K, Litterman, N, Luff, M, Mcintyre, M, Mcmanus, K, Mountain, J, Mozaffari, S, Noblin, E, Northover, C, O'Connell, J, Petrakovitz, A, Pitts, S, Poznik, G, Sathirapongsasuti, J, Shelton, J, Shringarpure, S, Tian, C, Tung, J, Tunney, R, Vacic, V, Wang, X, Zare, A, Mortensen, P, Mors, O, Werge, T, Nordentoft, M, Hougaard, D, Bybjerg-Grauholm, J, Baekvad-Hansen, M, Morisaki, T, de Geus, E, Bellocco, R, Okada, Y, Borglum, A, Joshi, P, Auton, A, Hinds, D, Neale, B, Walters, R, Nivard, M, Perry, J, Ganna, A, Pirastu N., Cordioli M., Nandakumar P., Mignogna G., Abdellaoui A., Hollis B., Kanai M., Rajagopal V. M., Parolo P. D. B., Baya N., Carey C. E., Karjalainen J., Als T. D., Van der Zee M. D., Day F. R., Ong K. K., Agee M., Aslibekyan S., Bell R. K., Bryc K., Clark S. K., Elson S. L., Fletez-Brant K., Fontanillas P., Furlotte N. A., Gandhi P. M., Heilbron K., Hicks B., Huber K. E., Jewett E. M., Jiang Y., Kleinman A., Lin K. -H., Litterman N. K., Luff M. K., McIntyre M. H., McManus K. F., Mountain J. L., Mozaffari S. V., Noblin E. S., Northover C. A. M., O'Connell J., Petrakovitz A. A., Pitts S. J., Poznik G. D., Sathirapongsasuti J. F., Shelton J. F., Shringarpure S., Tian C., Tung J. Y., Tunney R. J., Vacic V., Wang X., Zare A., Mortensen P. B., Mors O., Werge T., Nordentoft M., Hougaard D. M., Bybjerg-Grauholm J., Baekvad-Hansen M., Morisaki T., de Geus E., Bellocco R., Okada Y., Borglum A. D., Joshi P., Auton A., Hinds D., Neale B. M., Walters R. K., Nivard M. G., Perry J. R. B., and Ganna A.

Abstract

Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it requires the genotypes of unseen individuals. Here we demonstrate that it is possible to estimate comparative biases by performing a genome-wide association study contrasting one subgroup versus another. For example, we showed that sex exhibits artifactual autosomal heritability in the presence of sex-differential participation bias. By performing a genome-wide association study of sex in approximately 3.3 million males and females, we identified over 158 autosomal loci spuriously associated with sex and highlighted complex traits underpinning differences in study participation between the sexes. For example, the body mass index–increasing allele at FTO was observed at higher frequency in males compared to females (odds ratio = 1.02, P = 4.4 × 10−36). Finally, we demonstrated how these biases can potentially lead to incorrect inferences in downstream analyses and propose a conceptual framework for addressing such biases. Our findings highlight a new challenge that genetic studies may face as sample sizes continue to grow.

Published
2021

48. Maternal serum concentrations of bisphenol A and propyl paraben in early pregnancy are associated with male infant genital development

Author

Fisher, B. G., Thankamony, A., Mendiola, J., Petry, C. J., Frederiksen, H., Andersson, A. M., Juul, A., Ong, K. K., Dunger, D. B., Hughes, I. A., Acerini, C. L., Fisher, B. G., Thankamony, A., Mendiola, J., Petry, C. J., Frederiksen, H., Andersson, A. M., Juul, A., Ong, K. K., Dunger, D. B., Hughes, I. A., and Acerini, C. L.

Abstract

STUDY QUESTION: Are maternal serum phthalate metabolite, phenol and paraben concentrations measured at 10-17 weeks of gestation associated with male infant genital developmental outcomes, specifically cryptorchidism, anogenital distance (AGD), penile length and testicular descent distance, at birth and postnatally? SUMMARY ANSWER: Maternal serum bisphenol A (BPA) concentration at 10-17 weeks of gestation was positively associated with congenital or postnatally acquired cryptorchidism, and n-propyl paraben (n-PrP) concentration was associated with shorter AGD from birth to 24 months of age. WHAT IS KNOWN ALREADY: Male reproductive disorders are increasing in prevalence, which may reflect environmental influences on foetal testicular development. Animal studies have implicated phthalates, BPA and parabens, to which humans are ubiquitously exposed. However, epidemiological studies have generated conflicting results and have often been limited by small sample size and/or measurement of chemical exposures outside the most relevant developmental window. STUDY DESIGN, SIZE, DURATION: Case-control study of cryptorchidism nested within a prospective cohort study (Cambridge Baby Growth Study), with recruitment of pregnant women at 10-17 postmenstrual weeks of gestation from a single UK maternity unit between 2001 and 2009 and 24 months of infant follow-up. Of 2229 recruited women, 1640 continued with the infancy study after delivery, of whom 330 mothers of 334 male infants (30 with congenital cryptorchidism, 25 with postnatally acquired cryptorchidism and 279 unmatched controls) were included in the present analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS: Maternal blood was collected at enrolment, and serum levels of 16 phthalate metabolites, 9 phenols (including BPA) and 6 parabens were measured using liquid chromatography/tandem mass spectrometry. Logistic regression was used to model the association of cryptorchidism with serum chemical concentrations, adjusting for

Published
2020

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