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1. Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial

Author

Albert, Ben, Cai, Shirong, Calder, Philip C., Carvalho, Ryan, Guiao Castro, Julie Ann, Cavanagh, Mary, Chan, Jerry KY., Chang, Mei Ling, Chi, Claudia, Childs, Caroline E., Choh, Mei Kit, Chong, Mary FF., Chu, Anne HY., Conlon, Cathryn, Paula Costello, Cyrus Cooper, Cox, Vanessa, Galani, Sevasti, Hammond, Judith, Harvey, Nicholas C., Holt, Richard, Inskip, Hazel M., Jagtap, Mrunalini, Jeon, Gene, Karnani, Neerja, Nembrini, Chiara, Lillycrop, Karen A., Müller-Riemenschneider, Falk, Natarajan, Padmapriya, Ng, Sharon, Ramasamy, Adaikalavan, Tham, Elizabeth, Tint, Mya Thway, O’Sullivan, Justin M., Satianegara, Gernalia, Shek, Lynette PC., Silva-Zolezzi, Irma, Sim, Wendy, Soh, Shu E., Tay, Vicky, Taylor, Rachel, Theodosia, Salika, Wall, Clare, Woon, Gladys, Vickers, Mark, Ying, Wei, Chan, Shiao-Yng, Barton, Sheila J., Loy, See Ling, Chang, Hsin Fang, Titcombe, Philip, Wong, Jui-Tsung, Ebreo, Marilou, Ong, Judith, Tan, Karen ML., Nield, Heidi, El-Heis, Sarah, Kenealy, Timothy, Chong, Yap-Seng, Baker, Philip N., Cutfield, Wayne S., and Godfrey, Keith M.

Published
2023
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3. Higher Plasma Myo-Inositol in Pregnancy Associated with Reduced Postpartum Blood Loss: Secondary Analyses of the NiPPeR Trial.

Author

Chang, Hsin F., Yong, Hannah E. J., Han Zhang, Jui-Tsung Wong, Barton, Sheila J., Titcombe, Philip, Albert, Benjamin B., El-Heis, Sarah, Nield, Heidi, Ong, Judith, Lavelle, Luca, Ramos-Nieves, J. Manuel, Godin, Jean-Philippe, Silva-Zolezzi, Irma, Cutfield, Wayne S., Godfrey, Keith M., and Shiao-Yng Chan

Abstract

We previously reported that a combined myo-inositol, probiotics, and enriched micronutrient supplement (intervention) taken preconception and in pregnancy reduced postpartum blood loss (PBL) and major postpartum hemorrhage compared with a standard micronutrient supplement (control), as secondary outcomes of the NiPPeR trial. This study aimed to identify the intervention components that may contribute to this effect. Associations of plasma concentrations of myoinositol and vitamins B2, B6, B12, and D at preconception (before and after supplementation), early (~7-weeks), and late pregnancy (~28-weeks) with PBL were assessed by multiple linear regression, adjusting for site, ethnicity, preconception BMI, parity, and previous cesarean section. Amongst 583 women, a higher concentration of myo-inositol in early pregnancy was associated with a PBL reduction [βadj −1.26 (95%CI −2.23, −0.29) mL per µmol/L myo-inositol increase, p = 0.011]. Applying this co-efficient to the increase in mean 7-week-myo-inositol concentration of 23.4 µmol/L with the intervention equated to a PBL reduction of 29.5 mL (~8.4% of mean PBL of 350 mL among controls), accounting for 84.3% of the previously reported intervention effect of 35 mL. None of the examined vitamins were associated with PBL. Therefore, myo-inositol may be a key intervention component mediating the PBL reduction. Further work is required to determine the mechanisms involved [ABSTRACT FROM AUTHOR]

Published
2024
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7. Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial

Author

Chan, Shiao-Yng, primary, Barton, Sheila J., additional, Loy, See Ling, additional, Chang, Hsin Fang, additional, Titcombe, Philip, additional, Wong, Jui-Tsung, additional, Ebreo, Marilou, additional, Ong, Judith, additional, Tan, Karen ML., additional, Nield, Heidi, additional, El-Heis, Sarah, additional, Kenealy, Timothy, additional, Chong, Yap-Seng, additional, Baker, Philip N., additional, Cutfield, Wayne S., additional, Godfrey, Keith M., additional, Albert, Ben, additional, Cai, Shirong, additional, Calder, Philip C., additional, Carvalho, Ryan, additional, Guiao Castro, Julie Ann, additional, Cavanagh, Mary, additional, Chan, Jerry KY., additional, Chang, Mei Ling, additional, Chi, Claudia, additional, Childs, Caroline E., additional, Choh, Mei Kit, additional, Chong, Mary FF., additional, Chu, Anne HY., additional, Conlon, Cathryn, additional, Paula Costello, Cyrus Cooper, additional, Cox, Vanessa, additional, Galani, Sevasti, additional, Hammond, Judith, additional, Harvey, Nicholas C., additional, Holt, Richard, additional, Inskip, Hazel M., additional, Jagtap, Mrunalini, additional, Jeon, Gene, additional, Karnani, Neerja, additional, Nembrini, Chiara, additional, Lillycrop, Karen A., additional, Müller-Riemenschneider, Falk, additional, Natarajan, Padmapriya, additional, Ng, Sharon, additional, Ramasamy, Adaikalavan, additional, Tham, Elizabeth, additional, Tint, Mya Thway, additional, O’Sullivan, Justin M., additional, Satianegara, Gernalia, additional, Shek, Lynette PC., additional, Silva-Zolezzi, Irma, additional, Sim, Wendy, additional, Soh, Shu E., additional, Tay, Vicky, additional, Taylor, Rachel, additional, Theodosia, Salika, additional, Wall, Clare, additional, Woon, Gladys, additional, Vickers, Mark, additional, and Ying, Wei, additional

Published
2023
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9. BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study

Author

Mattar, Citra NZ, primary, Koh, Winston, additional, Seow, Yiqi, additional, Hoon, Shawn, additional, Venkatesh, Aparna, additional, Dashraath, Pradip, additional, Lim, Li Min, additional, Ong, Judith, additional, Lee, Rachel, additional, Johana, Nuryanti, additional, Yeo, Julie SL, additional, Chong, David, additional, Tan, Lay-Kok, additional, Chan, Jerry KY, additional, Choolani, Mahesh, additional, and Tambyah, Paul Anantharajah, additional

Published
2022
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11. Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination

Author

Mattar, Citra NZ, primary, Koh, Winston, additional, Seow, Yiqi, additional, Hoon, Shawn, additional, Venkatesh, Aparna, additional, Dashraath, Pradip, additional, Lim, Li Min, additional, Ong, Judith, additional, Lee, Rachel, additional, Johana, Nuryanti, additional, Yeo, Julie SL, additional, Chong, David, additional, Tan, Lay-Kok, additional, Chan, Jerry, additional, Choolani, Mahesh, additional, and Tambyah, Paul Anantharajah, additional

Published
2021
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