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7. Portal Hypertension

Author

Millar, Alastair J. W., Ong, Evelyn G. P., Ameh, Emmanuel A., editor, Bickler, Stephen W., editor, Lakhoo, Kokila, editor, Nwomeh, Benedict C., editor, and Poenaru, Dan, editor

Published
2020
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8. Obstructive Jaundice

Author

Uba, Francis Aba, Abdel-Latif, Mohammed, Hamza, Alaa F., Ong, Evelyn G. P., Ameh, Emmanuel A., editor, Bickler, Stephen W., editor, Lakhoo, Kokila, editor, Nwomeh, Benedict C., editor, and Poenaru, Dan, editor

Published
2020
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12. Incidence of Isolated Biliary Atresia during the COVID Lockdown in Europe: Results from a Collaborative Project by RARE-Liver

Author

Nomden, Mark, Alizai, Naved K., Betalli, Pietro, Bruggink, Janneke L.M., Cananzi, Mara, Christensen, Vibeke Brix, D’Antiga, Lorenzo, Davenport, Mark, Fischler, Björn, Hindemith, Luise, Hukkinen, Maria, Johansen, Lars S., de Kleine, Ruben H., Madadi-Sanjani, Omid, Ong, Evelyn G.P., Pakarinen, Mikko P., Petersen, Claus, Ruiz, Mathias, Schunn, Matthias, Sturm, Ekkehard, Verkade, Henkjan J., Wildhaber, Barbara E., Hulscher, Jan B.F., and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
COVID lockdown, biliary atresia, epidemiology, stringency index, European reference network RARE-LIVER
Abstract

Background: Biliary atresia (BA) is a rare cholangiopathy where one of the proposed aetiological mechanisms is an infectious viral trigger. Coronavirus disease-19 (COVID) lockdown restrictions were implemented to reduce the transmission of infections. Strictness of lockdown varied across European countries. This study aimed to investigate if there was an association between strictness of lockdown and change in isolated BA (IBA) incidence in Europe. Methods: We approached European centres involved in the European Reference Network RARE-LIVER. We included IBA patients born between 2015 and June 2020. We calculated the number of IBA patients born per centre per month. The Stringency Index (SI) was used as lockdown strictness indicator. The association between percentage change of mean number of IBA patients born per month and the SI was assessed. Results: We included 412 IBA patients from thirteen different centres. The median number of patients per month did not change: 6 (1–15) pre-lockdown and 7 (6–9) during lockdown (p = 0.34). There was an inverse association between SI and percentage change in IBA (B = -0.73, p = 0.03). Median age at Kasai portoenterostomy (days) did not differ between time periods (51 (9–179) vs. 53 (19–126), p = 0.73). Conclusion: In this European study, a stricter COVID-lockdown was seemingly accompanied by a simultaneous larger decrease in the number of IBA patients born per month in the lockdown. Results should be interpreted with caution due to the assumptions and limitations of the analysis.

Published
2023

13. Long‐term outcomes of pediatric liver transplantation using organ donation after circulatory death: Comparison between full and reduced grafts

Author

Alnagar, Amr, primary, Mirza, Darius F., additional, Muiesan, Paolo, additional, G. P. Ong, Evelyn, additional, Gupte, Girish, additional, Van Mourik, Indra, additional, Hartley, Jane, additional, Kelly, Deirdre, additional, Lloyd, Carla, additional, Perera, Thamara P. R., additional, and Sharif, Khalid, additional

Published
2022
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14. Malrotation

Author

Pierro, Agostino, Ong, Evelyn G. P., Lumley, J. S. P., editor, Siewert, J. R., editor, Puri, Prem, editor, and Höllwarth, Michael E., editor

Published
2006
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15. Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause

Author

Kelgeri, Chayarani, primary, Couper, Michael, additional, Gupte, Girish L., additional, Brant, Alexandra, additional, Patel, Mitul, additional, Johansen, Lauren, additional, Valamparampil, Joseph, additional, Ong, Evelyn, additional, Hartog, Hermien, additional, Perera, M.T.P.R., additional, Mirza, Darius, additional, van Mourik, Indra, additional, Sharif, Khalid, additional, and Hartley, Jane, additional

Published
2022
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22. Contributors

Author

Adams, Mark C., primary, Adzick, N. Scott, additional, Albanese, Craig T., additional, Alexander, Fred, additional, Altman, R. Peter, additional, Andrassy, Richard J., additional, Andrews, Walter S., additional, Applebaum, Harry, additional, Arca, Marjorie J., additional, Arensman, Robert M., additional, Atkinson, James B., additional, Azizkhan, Richard G., additional, Baban, Anwar, additional, Barnhart, Douglas C., additional, Bartlett, Robert H., additional, Baskin, Laurence S., additional, Beasley, Spencer W., additional, Bentz, Michael L., additional, Boston, Victor E., additional, Boulanger, Scott C., additional, Bove, Edward L., additional, Brandt, Mary L., additional, Brock, John W., additional, Brown, Rebeccah L., additional, Browne, Marybeth, additional, Buchmiller, Terry L., additional, Busuttil, Ronald W., additional, Caird, Michelle S., additional, Caldamone, Anthony A., additional, Campbell, Darrell A., additional, Caniano, Donna A., additional, Caty, Michael G., additional, Chung, Dai H., additional, Cilley, Robert E., additional, Colombani, Paul M., additional, Cooper, Joel D., additional, Coran, Arnold G., additional, Cotton, Robin T., additional, Dalsing, Michael C., additional, Daneman, Alan, additional, Davidoff, Andrew M., additional, Davidson, Richard S., additional, DeMarco, Romano T., additional, DeUgarte, Daniel A., additional, Devaney, Eric, additional, Didelot, William, additional, DiFiore, John W., additional, Dillon, Patrick A., additional, Dillon, Peter W., additional, Donahoe, Patricia K., additional, Dunn, James C.Y., additional, Eaton, Simon, additional, Eichelberger, Martin R., additional, Ein, Sigmund H., additional, Ells, Carolyn, additional, Eppley, Barry L., additional, Fallat, Mary E., additional, Farmer, Diana L., additional, Farmer, Douglas G., additional, Fishman, Steven J., additional, Flake, Alan W., additional, Foglia, Robert P., additional, Fonkalsrud, Eric W., additional, Ford, Henri R., additional, Fuller, Stephanie M.P., additional, Garcia, Victor F., additional, Gatti, John M., additional, Gauderer, Michael W.L., additional, Geiger, James D., additional, Georgeson, Keith E., additional, Gingalewski, Cynthia A., additional, Glassberg, Kenneth I., additional, Glick, Philip L., additional, Gordon, Sherilyn A., additional, Grikscheit, Tracy C., additional, Grosfeld, Jay L., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guzzetta, Philip C., additional, Harmon, Carroll M., additional, Harrison, Michael R., additional, Hayes-Jordan, Andrea A., additional, Hays, Stephen R., additional, Healey, John H., additional, Hendren, W. Hardy, additional, Hering, Bernhard J., additional, Herndon, David N., additional, Hirschl, Ronald B., additional, Holcomb, George W., additional, Huddleston, Charles B., additional, Hutchinson, Raymond J., additional, Hutson, John M., additional, Inge, Thomas, additional, Jasonni, Vincenzo, additional, Jibri, Nishwan, additional, Joyner, Byron D., additional, Kaefer, Martin, additional, Kawamoto, Henry K., additional, Kay, Robert M., additional, Kayes, Kosmas, additional, Kayton, Mark L., additional, Kelly, Robert E., additional, Kim, Stephen S., additional, Klein, Michael D., additional, Klement, Giannoula, additional, Krasin, Matthew J., additional, Krummel, Thomas M., additional, Laberge, Jean-Martin, additional, Landsman, Ira S., additional, La Quaglia, Michael P., additional, Lau, Stanley T., additional, Lee, Steven L., additional, Lelli, Joseph L., additional, Levitt, Marc A., additional, Lindahl, Harry, additional, Lobe, Thom E., additional, Loder, Randall T., additional, Luerssen, Thomas G., additional, Lukish, Jeffrey R., additional, Lund, Dennis P., additional, Madonna, Mary Beth, additional, Magee, John C., additional, Martucciello, Giuseppe, additional, Mathes, Stephen J., additional, McGahren, Eugene D., additional, McQuiston, Leslie T., additional, Metcalfe, Peter, additional, Millar, Alastair J.W., additional, Minevich, Eugene, additional, Miranda, Edward P., additional, Mitchell, Michael E., additional, Miyano, Takeshi, additional, Mount, Delora, additional, Mouriquand, Pierre, additional, Murase, Noriko, additional, Murphy, J. Patrick, additional, Nathan, Saminathan S., additional, Newman, Kurt D., additional, Numanoglu, Alp, additional, Nuss, Donald, additional, Ohye, Richard, additional, Oldham, Keith T., additional, O'Neill, James A., additional, Ong, Evelyn, additional, Oppenheim, William L., additional, Othersen, H. Biemann, additional, Pakarinen, Mikki, additional, Pandurangi, Keshav, additional, Pearl, Richard H., additional, Peña, Alberto, additional, Pieretti, Rafael V., additional, Pierro, Agostino, additional, Potsic, William P., additional, Puligandla, Pramod S., additional, Puapong, Devin P., additional, Puri, Prem, additional, Randolph, Judson G., additional, Rescorla, Frederick J., additional, Reyes, Jorge, additional, Ricketts, Richard R., additional, Rink, Richard C., additional, Rintala, Risto J., additional, Rocchini, Albert P., additional, Rode, Heinz, additional, Rodgers, Bradley M., additional, Sadove, A. Michael, additional, Saggi, Bob H., additional, Sanford, Arthur P., additional, Scherer, L.R., additional, Schnitzer, Jay J., additional, Schwartz, Marshall Z., additional, Shamberger, Robert C., additional, Shapiro, Nina L., additional, Sheldon, Curtis A., additional, Shochat, Stephen J., additional, Skinner, Michael A., additional, Smith, C.D., additional, Smith, Jodi L., additional, Smith, Samuel D., additional, Snyder, Charles L., additional, Spitz, Lewis, additional, Spray, Thomas L., additional, Starzl, Thomas E., additional, Stolar, Charles J.H., additional, Storm, Phillip B., additional, Stylianos, Steven, additional, Su, Wendy T., additional, Superina, Riccardo, additional, Sutherland, David E.R., additional, Sutton, Leslie N., additional, Tagge, Edward P., additional, Teitelbaum, Daniel H., additional, Templeman, Claire L., additional, Tekant, Gonca Topuzlu, additional, Tepas, Joseph J., additional, Thomas, Patrick B., additional, Thompson, Dana Mara, additional, Tovar, Juan A., additional, Upperman, Jeffrey S., additional, Vacanti, Joseph P., additional, Vane, Dennis W., additional, Vustar, Mirjana, additional, Warner, Brad W., additional, Weber, Thomas R., additional, Wesson, David E., additional, West, Karen W., additional, Wetmore, Ralph F., additional, Wiener, Eugene, additional, Wilson, Jay M., additional, Woo, Russell K., additional, Wu, Hsi-Yang, additional, Yerkes, Elizabeth, additional, Young, Daniel G., additional, and Ziegler, Moritz M., additional

Published
2006
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25. Fifteen-Year Single-Center Experience of Biliary Complications in Liver Trauma Patients: Changes in the Management of Posttraumatic Bile Leak.

Author

Stonelake, Stephen, Ali, Sana, Pinkey, Benjamin, Ong, Evelyn, Anbarasan, Ravindar, McGuirk, Simon, Perera, Thamera, Mirza, Darius, Muiesan, Paolo, and Sharif, Khalid

Subjects
INJURY complications, CHOLANGITIS, LENGTH of stay in hospitals, CHOLANGIOGRAPHY, ENDOSCOPIC retrograde cholangiopancreatography, RADIONUCLIDE imaging, DIAGNOSIS
Abstract

Introduction:  Management of posttraumatic bile leak has evolved over time in our unit, from endoscopic retrograde cholangiopancreatography (ERCP) stenting to intraperitoneal drainage (IPD) alone as first-line treatment for intraperitoneal bile leak.Materials and Methods:  Retrospective review of liver trauma patients from 2002 to 2017. Demographics, time and mode of diagnosis of bile leak, management, and outcome were analyzed of the box plot.Results:  In 118 patients, there were 28 traumatic bile leaks. Eighteen were free intraperitoneal and 10 were localized bilomas. The median time of diagnosis was 6 days following injury. The modes of diagnosis were preemptive hepatobiliary scintigraphy (18), computed tomography (CT) or ultrasound (7), and laparotomy (3). Free intraperitoneal biliary leak management included 11 IPD alone, 3 IPD plus ERCP, 2 IPD plus transcystic biliary stent (TBS), 1 operative cholangiogram, and 1 no intervention. Median time of IPD duration was 7 days (4-95) in IPD alone versus 14 days (6-40) in IPD + ERCP/TBS (p = 0.3). Median inpatient length of stay was 13 days (8-44) in IPD alone versus 12 days (8-22) in IPD + ERCP/TBS (p = 0.4).Conclusion:  Placement of IPD alone, as first-line treatment, is safe and effective in the management of intraperitoneal bile leaks, avoiding the costs and potential complications of ERCP. [ABSTRACT FROM AUTHOR]

Published
2021
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26. An investigation of minimisation criteria

Author

Pierro Agostino, Eaton Simon, Pan Huiqi, Wade Angie, and Ong Evelyn

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Minimisation can be used within treatment trials to ensure that prognostic factors are evenly distributed between treatment groups. The technique is relatively straightforward to apply but does require running tallies of patient recruitments to be made and some simple calculations to be performed prior to each allocation. As computing facilities have become more widely available, minimisation has become a more feasible option for many. Although the technique has increased in popularity, the mode of application is often poorly reported and the choice of input parameters not justified in any logical way. Methods We developed an automated package for patient allocation which incorporated a simulation arm. We here demonstrate how simulation of data can help to determine the input parameters to be used in a subsequent application of minimisation. Results Several scenarios were simulated. Within the selected scenarios, increasing the number of factors did not substantially adversely affect the extent to which the treatment groups were balanced with respect to the prognostic factors. Weighting of the factors tended to improve the balance when factors had many categories with only a slight negative effect on the factors with fewer categories. When interactions between factors were included as minimisation factors, there was no major reduction in the balance overall. Conclusion With the advent of widely available computing facilities, researchers can be better equipped to implement minimisation as a means of patient allocation. Simulations prior to study commencement can assist in the choice of minimisation parameters and can be used to justify those selections.

Published
2006
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28. Hepatopulmonary Syndrome in Children: A 20‐Year Review of Presenting Symptoms, Clinical Progression, and Transplant Outcome

Author

Warner, Suz, primary, McKiernan, Patrick J., additional, Hartley, Jane, additional, Ong, Evelyn, additional, van Mourik, Indra D., additional, Gupte, Girish, additional, Abdel‐Hady, Mona, additional, Muiesan, Paolo, additional, Perera, Thamera, additional, Mirza, Darius, additional, Sharif, Khalid, additional, Kelly, Deirdre A., additional, and Beath, Susan V., additional

Published
2018
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31. Intention to Split Policy

Author

Battula, Narendra R., primary, Platto, Marco, additional, Anbarasan, Ravindar, additional, Perera, M. Thamara P. R., additional, Ong, Evelyn, additional, Roll, Garrett R., additional, Ferraz Neto, Ben-Hur, additional, Mergental, Hynek, additional, Isaac, John, additional, Muiesan, Paolo, additional, Sharif, Khalid, additional, and Mirza, Darius F., additional

Published
2017
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34. A study on sensory properties of sodium reduction and replacement in Asian food using difference-from - control test.

Author

Leong, Jasmine, Kasamatsu, Chinatsu, Ong, Evelyn, Hoi, Jia Tse, and Loong, Mann Na

Subjects
TASTE testing of food, FOOD industry, FOOD testing, SODIUM content of food, SALTINESS (Taste)
Abstract

This study examined the effects of sodium reduction and flavor enhancers on the sensory profile of two types of hawker foods commonly consumed in Singapore, namely chicken rice and mee soto broth. The 'difference-from-control' test was the method adopted in this study involving 24-29 trained panelists. Combinations included blind control, two levels of sodium reduction, and two levels of flavor enhancers in sodium-reduced recipes. In the sodium-reduced recipes, two levels of NaCl, 0.48% and 0.55%, for chicken rice, and 0.76% and 0.86% for mee soto (equivalent to 31% and 22% reduction in NaCl), were used. Monosodium glutamate ( MSG) or Ajiplus® (a blend of MSG and nucleotides) at 0.20% and 0.40% were added to the recipes comprising a reduction of 40% in NaCl (equivalent to 31% and 22% reduction in sodium, respectively) compared with the control. It was found that the inclusion of MSG or Ajiplus® in 40% NaCl-reduced recipe resulted in a significant increase in perception of umami taste ( P < 0.05) when compared to the control. By adding flavor enhancers into the 40%-reduced salt chicken rice recipes, the perception of saltiness was significantly increased when compared to 22% and 31% sodium reduced recipes. Similarly for mee soto broth, there was a significant increase in perception of chicken flavor, umami taste, mouthfeel sensation, and sweet taste ( P < 0.05) with a decrease in the perception of sour and bitter taste when compared to control. By adding 0.40% MSG into the 40%-reduced salt recipes, the perception of saltiness was maintained when compared with control. [ABSTRACT FROM AUTHOR]

Published
2016
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41. The advice zone

Author

McCaul, James, primary, Jones, Emma, additional, Wilson, Mark, additional, Ong, Evelyn, additional, Skew, Peter, additional, and Beeching, Nick, additional

Published
2004
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43. Incidence of Isolated Biliary Atresia during the COVID Lockdown in Europe: Results from a Collaborative Project by RARE-Liver.

Author

Nomden M, Alizai NK, Betalli P, Bruggink JLM, Cananzi M, Christensen VB, D'Antiga L, Davenport M, Fischler B, Hindemith L, Hukkinen M, Johansen LS, de Kleine RH, Madadi-Sanjani O, Ong EGP, Pakarinen MP, Petersen C, Ruiz M, Schunn M, Sturm E, Verkade HJ, Wildhaber BE, Hulscher JBF, and On Behalf Of Members Of The Biliary Atresia And Related Disorders Bard Community The Ern Ra-Re-Liver

Abstract

Background: Biliary atresia (BA) is a rare cholangiopathy where one of the proposed aetiological mechanisms is an infectious viral trigger. Coronavirus disease-19 (COVID) lockdown restrictions were implemented to reduce the transmission of infections. Strictness of lockdown varied across European countries. This study aimed to investigate if there was an association between strictness of lockdown and change in isolated BA (IBA) incidence in Europe., Methods: We approached European centres involved in the European Reference Network RARE-LIVER. We included IBA patients born between 2015 and June 2020. We calculated the number of IBA patients born per centre per month. The Stringency Index (SI) was used as lockdown strictness indicator. The association between percentage change of mean number of IBA patients born per month and the SI was assessed., Results: We included 412 IBA patients from thirteen different centres. The median number of patients per month did not change: 6 (1-15) pre-lockdown and 7 (6-9) during lockdown ( p = 0.34). There was an inverse association between SI and percentage change in IBA (B = -0.73, p = 0.03). Median age at Kasai portoenterostomy (days) did not differ between time periods (51 (9-179) vs. 53 (19-126), p = 0.73)., Conclusion: In this European study, a stricter COVID-lockdown was seemingly accompanied by a simultaneous larger decrease in the number of IBA patients born per month in the lockdown. Results should be interpreted with caution due to the assumptions and limitations of the analysis.

Published
2023
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