11 results on '"One J"'
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2. Facade Style Mixing Using Artificial Intelligence for Urban Infill
- Author
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Ahmed Khairadeen Ali and One Jae Lee
- Subjects
artificial intelligence ,generative adversarial network ,machine learning ,computational design ,urban infill ,facade design ,Architecture ,NA1-9428 - Abstract
Artificial intelligence and machine learning, in particular, have made rapid advances in image processing. However, their incorporation into architectural design is still in its early stages compared to other disciplines. Therefore, this paper addresses the development of an integrated bottom–up digital design approach and describes a research framework for incorporating the deep convolutional generative adversarial network (GAN) for early stage design exploration and the generation of intricate and complex alternative facade designs for urban interiors. In this paper, a novel facade design is proposed using the architectural style, size, scale, and openings of two adjacent buildings as references to create a new building design in the same neighborhood for urban infill. This newly created building contains the outline, style and shape of the two main buildings. A 2D building design is generated as an image, where (1) neighboring buildings are imported as a reference using the cell phone and (2) iFACADE decodes their spatial neighborhood. It is illustrated that iFACADE will be useful for designers in the early design phase to create new facades in relation to existing buildings in a short time, saving time and energy. Moreover, building owners can use iFACADE to show their preferred architectural facade to their architects by mixing two building styles and creating a new building. Therefore, it is presented that iFACADE can become a communication platform in the early design phases between architects and builders. The initial results define a heuristic function for generating abstract facade elements and sufficiently illustrate the desired functionality of the prototype we developed.
- Published
- 2023
- Full Text
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3. Generic design aided robotically facade pick and place in construction site dataset
- Author
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Ahmed Khairadeen Ali, One Jae Lee, and Hayub Song
- Subjects
Robot in construction ,Generative design ,Facade design ,Automation in construction ,AI decision making ,Robotics in architecture ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
This Dataset provides a method of optimizing robot arm, facade pick and place locations in the construction site during facade assembly activity using generative design. A set of generative algorithms are provided in the form of graphical algorithm editors. The dataset is divided into three sets, each set controlling an essential subtask of facade assembly in the construction site. the dataset is called (iFOBOT) and consist of the following sub datasets: generative tool for facade population on building envelop (iFOBOT-D), Generative algorithm aided robot spatial location optimizer (iFOBOT-B), and Quantity take-off generative (iFOBOT-L). A sample project associated with its script and outcome results are included in this dataset to guide readers how to use this tool. This dataset only focuses on robot arm and facade module placement in construction sites. This dataset can generate optimized location of robot arm workstation in jobsite while also reducing robot collision with its body and surrounding objects, 2) reducing reachability rate, 3) reducing robot time travel during operation which in result minimize risk in facade assembly and increase productivity. This dataset is in parametric format which makes it reusable with all its history data using the reproducing guide provided here. More details of how to reuse this dataset and developed tool in construction site is covered in Robot-based Facade Spatial Assembly Optimization paper [1].
- Published
- 2020
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4. It is time to reconsider the use of naturally-occurring endotoxins in endotoxin recovery studies: Part 2 of a BioPhorum harmonized endotoxin recovery study.
- Author
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Bolden J, Knight M, Montz J, One J, Stockman S, and Jones SP
- Abstract
The evaluation of Naturally Occurring Endotoxins (NOEs) for Low Endotoxin Recovery (LER) studies has been a topic in the industry and regulatory agencies have been hesitant to endorse NOE use in LER studies over purified Lipopolysaccharide (LPS) standards such as Control Standard Endotoxin (CSE) or Reference Standard Endotoxin (RSE). In a recent study involving 11 BioPhorum member companies across 13 sites, NOEs prepared in high and low nutrient conditions were evaluated in two common monoclonal antibody buffer formulations: 10 mM Sodium Citrate, 0.05 % Polysorbate 80, pH 6.0 and 20 mM Histidine, 0.05 % Polysorbate 80, pH 6.0. 12 g-negative bacterial isolates were used to prepare NOE analytes, which were spiked into the formulation buffers. Additionally, the NOEs were spiked into Limulus Amebocyte Lysate (LAL) reagent water as controls and purified LPS into the citrate/polysorbate buffer as the LER control. Results showed the average of three runs per organism was >50 % recovery, at the conclusion of the 7-day period, regardless of nutrient culture preparation conditions. Furthermore, purified LPS controls became undetectable (<50 % recovery) in the citrate/polysorbate buffer, highlighting the presence of LER. These findings highlight the potential value of using NOEs from relevant manufacturing facilities to assess overall risk when purified LPS recovery is insufficient., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
5. Ibuprofen Lyell's Syndrome In An Eight-Year-Old Child.
- Author
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Koffi NR, Pete Y, N'Da KC, Ory OA, One JL, Ogondon B, Kouadio S, Able E, Irie B, Kouame KE, and Brouh Y
- Abstract
Lyell's syndrome or toxic epidermal necrolysis (TEN) is a rare but serious drug-like toxiderma. Treated as a recent extensive burn in intensive care, its management must be urgent, and adapted in order to improve the vital prognosis of patients and reduce their mortality. We report a severe case of Lyell's syndrome occurring 24 hours after oral administration of an anti-inflammatory drug (ibuprofen) as a self-medication in an eight-year-old child., (© 2023 Euro-Mediterranean Council for Burns and Fire Disasters.)
- Published
- 2023
6. Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
- Author
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Boon R, Kumar M, Tricot T, Elia I, Ordovas L, Jacobs F, One J, De Smedt J, Eelen G, Bird M, Roelandt P, Doglioni G, Vriens K, Rossi M, Vazquez MA, Vanwelden T, Chesnais F, El Taghdouini A, Najimi M, Sokal E, Cassiman D, Snoeys J, Monshouwer M, Hu WS, Lange C, Carmeliet P, Fendt SM, and Verfaillie CM
- Subjects
- Cell Differentiation physiology, Cell Line, Tumor, Cytochrome P-450 CYP3A, Female, Gene Knockout Techniques, Hep G2 Cells, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 3-gamma, High-Throughput Screening Assays, Homeodomain Proteins, Humans, Liver, Male, Metabolic Engineering, Metabolic Networks and Pathways, Middle Aged, Pluripotent Stem Cells, Stem Cells, Transcriptome, Tumor Suppressor Proteins, Amino Acids metabolism, Carcinoma, Hepatocellular metabolism, Cytochrome P-450 Enzyme System metabolism, Hepatocytes metabolism, Liver Neoplasms metabolism
- Abstract
Predicting drug-induced liver injury in a preclinical setting remains challenging, as cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived hepatocyte-like cells (HLCs), and hepatoma cells exhibit poor drug biotransformation capacity. We here demonstrate that hepatic functionality depends more on cellular metabolism and extracellular nutrients than on developmental regulators. Specifically, we demonstrate that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG2 cells induces glucose independence, mitochondrial function, and the acquisition of a transcriptional profile that is closer to PHHs. Moreover, we show that these high levels of amino acids are sufficient to drive HLC and HepG2 drug biotransformation and liver-toxin sensitivity to levels similar to those in PHHs. In conclusion, we provide data indicating that extracellular nutrient levels represent a major determinant of cellular maturity and can be utilized to guide stem cell differentiation to the hepatic lineage.
- Published
- 2020
- Full Text
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7. Correction to: Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance.
- Author
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Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, and Cook JA
- Abstract
Following publication of the original article [1], we have been notified of a few mistakes.
- Published
- 2019
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8. Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA 2 guidance.
- Author
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Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, and Cook JA
- Subjects
- Consensus, Data Interpretation, Statistical, Delphi Technique, Humans, Randomized Controlled Trials as Topic standards, Randomized Controlled Trials as Topic statistics & numerical data, Treatment Outcome, Clinical Trial Protocols as Topic, Numbers Needed To Treat standards, Randomized Controlled Trials as Topic methods
- Abstract
Background: A key step in the design of a randomised controlled trial is the estimation of the number of participants needed. The most common approach is to specify a target difference in the primary outcome between the randomised groups and then estimate the corresponding sample size. The sample size is chosen to provide reassurance that the trial will have high statistical power to detect the target difference at the planned statistical significance level. Alternative approaches are also available, though most still require specification of a target difference. The sample size has many implications for the conduct of the study, as well as incurring scientific and ethical aspects. Despite the critical role of the target difference for the primary outcome in the design of a randomised controlled trial (RCT), the manner in which it is determined has received little attention. This article reports the development of the DELTA
2 guidance on the specification and reporting of the target difference for the primary outcome in a sample size calculation for a RCT., Methods: The DELTA2 (Difference ELicitation in TriAls) project has five components comprising systematic literature reviews of recent methodological developments (stage 1) and existing funder guidance (stage 2), a Delphi study (stage 3), a 2-day consensus meeting bringing together researchers, funders and patient representatives (stage 4), and the preparation and dissemination of a guidance document (stage 5)., Results: The project started in April 2016. The literature search identified 28 articles of methodological developments relevant to a method for specifying a target difference. A Delphi study involving 69 participants, along with a 2-day consensus meeting were conducted. In addition, further engagement sessions were held at two international conferences. The main guidance text was finalised on April 18, 2018, after revision informed by feedback gathered from stages 2 and 3 and from funder representatives., Discussion: The DELTA2 Delphi study identified a number of areas (such as practical recommendations and examples, greater coverage of different trial designs and statistical approaches) of particular interest amongst stakeholders which new guidance was desired to meet. New relevant references were identified by the review. Such findings influenced the scope, drafting and revision of the guidance. While not all suggestions could be accommodated, it is hoped that the process has led to a more useful and practical document.- Published
- 2018
- Full Text
- View/download PDF
9. SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
- Author
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García-León JA, Kumar M, Boon R, Chau D, One J, Wolfs E, Eggermont K, Berckmans P, Gunhanlar N, de Vrij F, Lendemeijer B, Pavie B, Corthout N, Kushner SA, Dávila JC, Lambrichts I, Hu WS, and Verfaillie CM
- Subjects
- Amyotrophic Lateral Sclerosis genetics, Amyotrophic Lateral Sclerosis therapy, Antigens, Surface genetics, Gene Expression Regulation, Developmental, Humans, Multiple Sclerosis genetics, Multiple Sclerosis pathology, Multiple Sclerosis therapy, Myelin Basic Protein genetics, Neurons pathology, Neurons transplantation, Oligodendroglia cytology, Oligodendroglia transplantation, Pluripotent Stem Cells cytology, Pluripotent Stem Cells transplantation, Transcriptome genetics, Cell Differentiation genetics, Oligodendroglia metabolism, Pluripotent Stem Cells metabolism, SOXE Transcription Factors genetics
- Abstract
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel therapies. Here, we demonstrate that overexpression of the transcription factor SOX10 is sufficient to generate surface antigen O4-positive (O4
+ ) and myelin basic protein-positive OLs from hPSCs in only 22 days, including from patients with multiple sclerosis or amyotrophic lateral sclerosis. The SOX10-induced O4+ population resembles primary human OLs at the transcriptome level and can myelinate neurons in vivo. Using in vitro OL-neuron co-cultures, myelination of neurons by OLs can also be demonstrated, which can be adapted to a high-throughput screening format to test the response of pro-myelinating drugs. In conclusion, we provide an approach to generate OLs in a very rapid and efficient manner, which can be used for disease modeling, drug discovery efforts, and potentially for therapeutic OL transplantation., (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2018
- Full Text
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10. Tissue-engineered vascular grafts created from human induced pluripotent stem cells.
- Author
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Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang AH, and Niklason L
- Subjects
- Antigens, Differentiation biosynthesis, Cell Line, Extracellular Matrix metabolism, Humans, Blood Vessel Prosthesis, Induced Pluripotent Stem Cells cytology, Induced Pluripotent Stem Cells metabolism, Tissue Engineering methods
- Abstract
The utility of human induced pluripotent stem cells (hiPSCs) to create tissue-engineered vascular grafts was evaluated in this study. hiPSC lines were first induced into a mesenchymal lineage via a neural crest intermediate using a serum-free, chemically defined differentiation scheme. Derived cells exhibited commonly known mesenchymal markers (CD90, CD105, and CD73 and negative marker CD45) and were shown to differentiate into several mesenchymal lineages (osteogenic, chondrogenic, and adipogenic). Functional vascular grafts were then engineered by culturing hiPSC-derived mesenchymal progenitor cells in a pulsatile bioreactor system over 8 weeks to induce smooth muscle cell differentiation and collagenous matrix generation. Histological analyses confirmed layers of calponin-positive smooth muscle cells in a collagen-rich matrix. Mechanical tests revealed that grafts had an average burst pressure of 700 mmHg, which is approximately half that of native veins. Additionally, studies revealed that karyotypically normal mesenchymal stem cell clones led to generation of grafts with predicted features of engineered vascular grafts, whereas derived clones having chromosomal abnormalities generated calcified vessel constructs, possibly because of cell apoptosis during culture. Overall, these results provide significant insight into the utility of hiPS cells for vascular graft generation. They pave the way for creating personalized, patient-specific vascular grafts for surgical applications, as well as for creating experimental models of vascular development and disease., (©AlphaMed Press.)
- Published
- 2014
- Full Text
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11. [Transbronchofiberscopic aspiration biopsy using a special catheter (author's transl)].
- Author
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Kato H, One J, Niizuma M, Seo Y, Konaka C, Hayashi N, Kawamura I, Oho K, and Hayata Y
- Subjects
- Adenocarcinoma, Bronchiolo-Alveolar diagnosis, Adult, Carcinoid Tumor diagnosis, Catheterization instrumentation, Female, Fiber Optic Technology, Humans, Lung Neoplasms diagnosis, Male, Middle Aged, Tuberculosis, Lymph Node diagnosis, Biopsy, Needle instrumentation, Bronchoscopes
- Published
- 1978
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