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21 results on '"Onderwater, Jos"'

6. The microtubule plus-end tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis

Author

Akhmanova, Anna, Mausset-Bonnefont, Anne-Laure, Cappellen, Wiggert van, Keihzer, Nanda, Hoogenraad, Casper C., Stepanova, Tatiana, Drabek, Ksenija, Wees, Jacqueline van der, Mommaas, Mieke, Onderwater, Jos, Meulen, Hans van der, Tanenbaum, Marvin E., Medema, Rene H., Hoogerbrugge, Jos, Vreeburg, Jan, Uringa, Evert-Jan, Grootegoed, J.Anton, Grosveld, Frank, and Galjart, Niels

Subjects
Spermatogenesis in animals -- Research, Mice -- Genetic aspects, Cytoplasmic filaments -- Research, Biological sciences
Abstract

The function of mouse cytoplasmic linker protein of 170 kDa (CLIP-170) is examined. It is found that Clip-170 is able to act both as a (+)TIP and as a structural protein and is also important for normal spermatogenesis.

Published
2005

7. Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta

Author

CMM Groep Coffer, Regenerative Medicine and Stem Cells, Infection & Immunity, Boisset, Jean-Charles, Clapes, Thomas, Klaus, Anna, Papazian, Natalie, Onderwater, Jos, Mommaas-Kienhuis, Mieke, Cupedo, Tom, Robin, Catherine, CMM Groep Coffer, Regenerative Medicine and Stem Cells, Infection & Immunity, Boisset, Jean-Charles, Clapes, Thomas, Klaus, Anna, Papazian, Natalie, Onderwater, Jos, Mommaas-Kienhuis, Mieke, Cupedo, Tom, and Robin, Catherine

Published
2015

8. ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

Author

Heijmans, Jarom, primary, van Lidth de Jeude, Jooske F., additional, Koo, Bon-Kyoung, additional, Rosekrans, Sanne L., additional, Wielenga, Mattheus C.B., additional, van de Wetering, Marc, additional, Ferrante, Marc, additional, Lee, Amy S., additional, Onderwater, Jos J.M., additional, Paton, James C., additional, Paton, Adrienne W., additional, Mommaas, A. Mieke, additional, Kodach, Liudmila L., additional, Hardwick, James C., additional, Hommes, Daniël W., additional, Clevers, Hans, additional, Muncan, Vanesa, additional, and van den Brink, Gijs R., additional

Published
2013
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12. Structural Protein Requirements in Equine Arteritis Virus Assembly

Author

Wieringa, Roeland, primary, de Vries, Antoine A. F., additional, van der Meulen, Jannes, additional, Godeke, Gert-Jan, additional, Onderwater, Jos J. M., additional, van Tol, Hans, additional, Koerten, Henk K., additional, Mommaas, A. Mieke, additional, Snijder, Eric J., additional, and Rottier, Peter J. M., additional

Published
2004
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14. Mannose receptor‐mediated uptake of antigens strongly enhances HLA class II‐restricted antigen presentation by cultured dendritic cells

Author

Tan, M. C. Agnes A., primary, Mommaas, A. Mieke, additional, Drijfhout, Jan Wouter, additional, Jordens, Reina, additional, Onderwater, Jos J. M., additional, Verwoerd, Desiree, additional, Mulder, Aat A., additional, van der Heiden, Annette N., additional, Scheidegger, Doris, additional, Oomen, Lauran C. J. M., additional, Ottenhoff, Tom H. M., additional, Tulp, Abraham, additional, Neefjes, Jacques J., additional, and Koning, Frits, additional

Published
1997
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17. Morphological changes of the dermatophyte Trichophyton rubrum after photodynamic treatment: a scanning electron microscopy study.

Author

Smijs, Threes G. M., Mulder, Aat A., Pavel, Stan, Onderwater, Jos J. M., Koerten, Henk K., and Bouwstra, Joke A.

Abstract

Treatment strategies for superficial mycosis caused by the dermatophyte Trichophyton rubrum consist of the use of topical or oral antifungal preparations. We have recently discovered that T. rubrum is susceptible to photodynamic treatment (PDT), with 5,10,15-tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride (Sylsens B) as a photosensitizer. The susceptibility appeared to depend on the fungal growth stage, with PDT efficacy higher with microconidia when compared to mycelia. The aim of this study was to investigate, with the use of scanning electron microscopy, the morphological changes caused by a lethal PDT dose to T. rubrum when grown on isolated human stratum corneum. Corresponding dark treatment and light treatment without photosensitizer were used as controls. A sub-lethal PDT dose was also included in this investigation The morphologic changes were followed at various time points after the treatment of different fungal growth stages. Normal fungal growth was characterized by a fiber-like appearance of the surface of the hyphae and microconidia with the exception of the hyphal tips in full mycelia and the microconidia shortly after attachment to the stratum corneum. Here, densely packed globular structures were observed. The light dose (108 J/cm2) in the absence of Sylsens B, or the application of the photosensitizer in the absence of light, caused reversible fungal wall deformations and bulge formation. However, after a lethal PDT, a sequence of severe disruptions and deformations of both microconidia and the mycelium were observed leading to extrusion of cell material and emptied fungal elements. In case of a non-lethal PDT, fungal re-growth started on the remnants of the treated mycelium. [ABSTRACT FROM AUTHOR]

Published
2008
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19. Localization of the Low-MrSubunit of Cytochrome b558in Human Blood Phagocytes by Immunoelectron Microscopy

Author

Ginsel, Leo A., Onderwater, Jos J.M., Fransen, Jack A.M., Verhoeven, Arthur J., and Roos, Dirk

Abstract

Cytochrome b558is a membrane-bound component of the NADPH-oxidase system in phagocytes and consists of a low-Mrsubunit of 22 to 23 Kd and a high-Mrsubunit of 75 to 90 Kd. The present study on the subcellular localization of the low Mrsubunit of cytochrome b558(p22-phox) in resting human peripheral blood phagocytes was based on immunogold labeling with monoclonal antibody (MoAb) 449, recently characterized. In post-embedding labeled neutrophils, this subunit was found mainly in the membrane of the specific granules. This conclusion was supported by a quantitative analysis of the results obtained in immunogold double-labeled sections with a polyclonal antiserum against lactoferrin (LF) as a marker for specific granules and a polyclonal antiserum against myeloperoxidase (MPO) used to identify azurophil granules. No labeling of the plasma membrane was observed, because of limited penetration of the antibody into the cryosections, preventing the detection of low antigen concentrations. Pre-embedding labeling of digitonin-permeabilized neutrophils, which has the advantage of a better penetration of the antibody into the cells, showed intense immunoreactivity on the cytoplasmic side of intact granules and low labeling on the inner surface of the plasma membrane. These complementary findings indicate that in resting neutrophils the epitope of p22-phox,recognized by MoAb 449, is present on the cytoplasmic side of the membrane of specific granules and the plasma membrane. Similar observations were made in eosinophils, where MoAb 449 reacted strongly with the cytoplasmic side of numerous small granules, and a low level of labeling was observed on the inner surface of the plasma membrane. In monocytes, MoAb 449 labeling also occurred on the inner surface of plasma membrane, of endocytotic compartments, and the outer surface of relatively small granules differing from peroxidase-containing lysosomes, as shown by immunogold double-labeling with MPO.

Published
1990
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