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Byline: Memorial Sloan-Kettering Cancer Center NEW YORK, Dec. 24 (AScribe Newswire) -- Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by [...]

A report, 'Effects of motexafin gadolinium in a phase II trial in refractory chronic lymphocytic leukemia,' is newly published data in Leukemia & Lymphoma. 'Chronic lymphocytic leukemia (CLL) cells are [...]

Fresh data on life sciences are presented in the report 'The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer.' According [...]

New investigation results, 'Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression,' are detailed in a study published in Neoplasia. 'The cancer stem cell paradigm postulates that [...]

'Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps [...]

'Signal transducer and activator of transcription-3 (STAT3) is downstream of growth factor and cytokine receptors, and regulates key oncogenic pathways in non-small cell lung cancer (NSCLC). Activation of STAT3 by [...]

'p21-activated kinase 1 (Pak1), a serine/threonine kinase, has been implicated in cytoskeletal remodelling, cell motility, apoptosis and transformation. However, the role of Pak1 in gastric cancer remains unclear,' scientists in [...]

'We explored whether adipocyte Culture medium affects the secreted chemokine profile of tumor cells, because adipocytes stimulate progression or metastasis of breast cancer cells, and chemokines secreted from tumor cells [...]

New investigation results, 'Biochemical and pathological response of prostate cancer in a patient with metastatic renal cell carcinoma on sunitinib treatment,' are detailed in a study published in Japanese Journal [...]

Data detailed in 'Manipulating prohibitin levels provides evidence for an in vivo role in androgen regulation of prostate tumours' have been presented. 'Current hormonal therapies for prostate cancer are effective [...]

'Lindera erythrocarpa Makino (Lauraceae) is used as a traditional medicine for analgesic, antidote, and antibacterial purposes and shows anti-tumor activity. We studied the effects of Lindera erythrocarpa on the human [...]

A report, 'CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer,' is newly published data in British Journal of Cancer. 'Endocrine therapies of breast cancer are effective but [...]

According to a study from the United States, 'The cytochrome P450 enzyme, CYP1B1, is an established target in prostate cancer chemoprevention. Compounds inhibiting CYP1B1 activity are contemplated to exert beneficial [...]

According to a study from Rome, Italy, 'This multinational, double-blind, randomized, placebo-controlled, phase III trial assessed the efficacy and tolerability of the oral platinum analog satraplatin in patients with metastatic [...]

'Little is known about the molecules that contribute to tumor progression of epithelial ovarian cancer (EOC), currently a leading cause of mortality from gynecological malignancies. Glucocorticoid-Induced Leucine Zipper (GILZ), an [...]

Researchers at Uppsala University and University Children's Hospital in Uppsala have devised powerful new tools for typing cells from children with acute lymphatic leukemia and for prediction of how children [...]

Scientists discuss in 'Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha' new findings in angiogenesis. 'Hypoxia contributes to the progression of a variety of cancers [...]

Current study results from the report, 'Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge,' have been published. According to recent research published in the journal Oncogene, [...]

'Regulatory T cell (Treg) frequency and activity are increased in cancer patients and play a major role in tumor escape. Although disease progression is favored by the presence of Treg, [...]

Fresh data on tics are presented in the report 'Capecitabine in the routine treatment of advanced breast cancer: results from a non-interventional observational study in 870 patients.' 'This observational study [...]

A new study, 'Local expression of insulin-like growth factor-I, insulin-like growth factor-I receptor, and estrogen receptor alpha in ovarian cancer,' is now available. According to a study from Harbin, People's [...]

Investigators publish new data in the report 'Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.' 'Tumor-associated macrophages mediate the link between [...]

'and background. Carboxylesterase-2 has been identified as the key enzyme in the metabolic activation of irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors,' scientists [...]

'Arsenite is a well-known human carcinogen that especially targets skin. The tumor progression locus 2 (Tpl2) gene encodes a serine/threonine protein kinase that is over-expressed in various cancer cells,' scientists [...]

'EGFR is a major anticancer drug target in human epithelial. tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib,' scientists in the [...]

A report, 'Second-line chemotherapy with biweekly paclitaxel after failure of fluoropyrimidine-based treatment in patients with advanced or recurrent gastric cancer: a report from the gastrointestinal oncology group of the Tokyo [...]

'Little data are available on radical prostatectomy findings in men who experience disease progression following active surveillance. A total of 470 men in our active surveillance program underwent annual repeat [...]

'Squamous cell carcinoma (SCC) of the skin is the most clinically aggressive form of non-melanoma skin cancer. We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring [...]

'Cathepsin S is a cysteine protease that promotes the invasion of tumor and endothelial cells during cancer progression. Here we investigated the potential to target cathepsin S using an antagonistic [...]

According to a study from Osaka, Japan, 'Since the 1970s, it has been well known that long-standing ulcerative colitis (UC) disposes to the development of colorectal adenocarcinoma (CRC). To date, [...]

'Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is [...]

According to a study from Perth, Australia, 'MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and are aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is [...]

A new study, 'Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells,' is [...]

According to a study from the United States, 'In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer [...]

Current study results from the report, 'Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells,' have been published. According to [...]

A new study, 'The promiscuous receptor,' is now available. 'To determine the effectiveness of vitamin D therapy in patients with asymptomatic, prostate-specific antigen (PSA)-progression of prostate cancer. Twenty-six patients with [...]

New research, 'Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export,' is the subject of a report. According to a study from Tokyo, [...]

New research, 'Mouse orthotopic models for bladder cancer research,' is the subject of a report. According to recent research published in the journal Bju International, 'Bladder cancer is a common [...]

'Androgen receptors have been shown to play a critical role in prostate cancer. We used ultrasound imaging techniques to track tumor response to antiandrogen and rapamycin treatment in a prostate-specific [...]

'Suppressor of cytokine signaling-3 (SOCS-3) acts as a negative feedback regulator of the Janus-activated kinase/signal transducers and activators of transcription factors signaling pathway and plays an important role in the [...]

According to a study from Barcelona, Spain, 'Colorectal cancer is the second cause of cancer-related death in the western world, and although the genetic and molecular mechanisms involved in the [...]

'Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this Study was to determine 8-hydroxydeoxyguanosine (8-OHdG) level as a market of [...]

According to a study from the United States, 'Multiple genome-wide association studies have identified several susceptibility variants for colon cancer at 8q24. However, the functional roles of these variants have [...]

A new study, 'Differential expression of galectin-3, beta-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands,' is now available. 'Galectin-3 has been implicated in [...]

According to a study from Norway, 'The interleukin-8 (IL-8) network is involved in the colorectal cancer (CRC) progression. However, its role during the adenoma-carcinoma transition to date has not been [...]

'High levels of activated Stat3 are often found in human breast cancers and can correlate with poor patient outcome,' researchers in Montreal, Canada report (see also Breast Cancer). 'We employed [...]