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3. Diagnostic dilemma of paraneoplastic arthritis: case series

Author

KISACIK, Bunyamin, ONAT, Ahmet M., KASIFOGLU, Timucin, PEHLIVAN, Yavuz, PAMUK, Omer N., DALKILIC, Ediz, DONMEZ, Salim, BILGE, Sule Y., YILMAZ, Sedat, ERDEM, Hakan, MERCAN, Ridvan, OZTURK, Mehmet A., BES, Cemal, SOY, Mehmet, ERTEN, Sukran, COBANKARA, Veli, SENEL, Soner, ONER, Fatma A., DIRESKENELI, Haner, YILMAZ, Sema, YAZICI, Ayten, EMMUNGIL, Hakan, AKSU, Kenan, KUL, Seval, CETIN, Gozde Y., and SAYARLIOGLU, Mehmet

Published
2014
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6. Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis

Author

Oztuzcu, Serdar, Onat, Ahmet M., Pehlivan, Yavuz, Alibaz-Oner, Fatma, Donmez, Salim, Cetin, Gozde Y., Demiryurek, Abdullah T., and Ondokuz Mayıs Üniversitesi

Subjects
haplotype, transient receptor potential melastatin, systemic sclerosis, Cation channels, scleroderma, polymorphism
Abstract

bozgeyik, ibrahim/0000-0003-1483-2580; Demiryurek, Abdullah/0000-0003-4762-4745 WOS: 000365993400016 PubMed: 26546534 Background/Aim: Systemic sclerosis (SSc) is an inflammatory disease characterized by vascular abnormalities and fibrosis. The aim of the present study was to investigate the possible role of transient receptor potential melastatin (TRPM) channel genes in the susceptibility and phenotype expression of SSc. Materials and Methods: A total of 339 patients with SSc and 302 healthy controls were studied. Genomic DNA was extracted from leukocytes of the peripheral blood, and 25 single nucleotide polymorphisms in the TRPM channel genes were analyzed by the BioMark HD dynamic array system. Results: There were marked increases in the CC genotype (94.7% vs 81.8%, p

Published
2015

8. Diagnostic dilemma of paraneoplastic arthritis: case series

Author

Yavuz Pehlivan, Kenan Aksu, Mehmet Soy, Ediz Dalkilic, Hakan Emmungil, Sema Yilmaz, Bunyamin Kisacik, Sedat Yilmaz, Fatma Alibaz Öner, Şule Yaşar Bilge, Haner Direskeneli, Veli Cobankara, Seval Kul, Ömer Nuri Pamuk, Rıdvan Mercan, Soner Senel, Ayten Yazici, Ahmet Mesut Onat, Mehmet Akif Ozturk, Hakan Erdem, Salim Dönmez, Şükran Erten, Cemal Bes, Mehmet Sayarlioglu, Timuçin Kaşifoğlu, Gozde Yildirim Cetin, [Kisacik, Bunyamin -- Onat, Ahmet M. -- Pehlivan, Yavuz -- Kul, Seval] Gaziantep Univ, Fac Med, Div Rheumatol, Dept Internal Med, TR-27100 Sahinbey, Gaziantep, Turkey -- [Kasifoglu, Timucin -- Bilge, Sule Y.] Osmangazi Univ, Fac Med, Eskisehir, Turkey -- [Pamuk, Omer N. -- Donmez, Salim] Trakya Univ, Fac Med, Edirne, Turkey -- [Dalkilic, Ediz] Uludag Univ, Fac Med, Bursa, Turkey -- [Yilmaz, Sedat -- Erdem, Hakan] Gulhane Mil Med Acad, Ankara, Turkey -- [Mercan, Ridvan -- Ozturk, Mehmet A.] Gazi Univ, Fac Med, Ankara, Turkey -- [Bes, Cemal -- Soy, Mehmet] AbantIzzetBaysal Univ Med, Bolu, Turkey -- [Erten, Sukran] Ataturk Hosp, Minist Hlth, Div Rheumatol, Ankara, Turkey -- [Erten, Sukran] Dept Internal Med, Div Rheumatol, Ankara, Turkey -- [Cobankara, Veli] Pamukkale Univ, Fac Med, Ankara, Turkey -- [Senel, Soner] Cumhuriyet Univ, Fac Med, Denizli, Turkey -- [Oner, Fatma A. -- Direskeneli, Haner] Marmara Univ, Fac Med, Istanbul, Turkey -- [Yilmaz, Sema] Selcuk Univ, Selcuklu Fac Med, Konya, Turkey -- [Yazici, Ayten] Sakarya Res & Training Hosp, Div Rheumatol, Sakarya, Turkey -- [Emmungil, Hakan -- Aksu, Kenan] Ege Univ, Fac Med, Izmir, Turkey -- [Cetin, Gozde Y. -- Sayarlioglu, Mehmet] Kahramanmaras Sutcu Imam Univ, Fac Med, TR-46050 Kahramanmaras, Turkey, mercan, ridvan -- 0000-0003-1537-2192, SOY, MEHMET -- 0000-0003-1710-7018, and aksu, kenan -- 0000-0001-8889-2688

Subjects
Male, Turkey, Paraneoplastic Syndromes, early rheumatoid arthritis, Arthritis, immunology, Arthritis, Rheumatoid, differential diagnosis, joint, Young adult, Oligoarthritis, predictive value, cyclic citrullinated peptide, clinical trial, Middle Aged, biological marker, Treatment Outcome, Antirheumatic Agents, Polyarthritis, Biological Markers, Female, Adult, medicine.medical_specialty, Malignancy, Early rheumatoid arthritis, Peptides, Cyclic, Diagnosis, Differential, Rheumatology, cyclopeptide, blood, Predictive Value of Tests, Rheumatoid Factor, Internal medicine, medicine, Rheumatoid factor, Humans, human, Aged, L-Lactate Dehydrogenase, business.industry, paraneoplastic arthritis, lactate dehydrogenase, case control study, medicine.disease, Paraneoplastic arthritis, multicenter study, Case-Control Studies, Immunology, antirheumatic agent, pathology, Joints, business, Biomarkers, malignancy
Abstract

WOS: 000344362300007, PubMed ID: 24433553, Objectives: Paraneoplastic arthritis (PA) may mimic rheumatic diseases. While presenting the demographic and laboratory features of the patients diagnosed with PA, this study also aims to provide possible appropriate tools to differentiate the PA cases from early rheumatoid arthritis (ERA). Methods: Sixty-five patients with PA (male/female: 43/22) from 15 different rheumatology clinics and 50 consecutive patients with ERA (male/female: 13/37) fulfilling the 2010 American College of Rheumatology (ACR) criteria for the diagnosis if the RA from Gaziantep Rheumatology Early Arthritis Trial (GREAT) as controls who were diagnosed at least 12 months before, were enrolled into study. Results: Mean ages of the patients with PA and ERA were 50.2 +/- 15.3, and 42.7 +/- 12.3, respectively, and the mean ages of the patients with PA were significantly higher than the ERA. Unlike the ERA patients, in our case series PA was predominantly observed among males. Oligoarthritis was significantly higher in solid tumors in contrast to ERA (P = 0.001). Polyarthritis and symmetric arthritis were significantly higher in the ERA group in contrast to all malignancies (P = 0.001). Rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) positivity were significantly higher in the ERA group (each P = 0.001). Lactic dehydrogenase levels of hematologic malignancies were significantly higher than other groups (each, P = 0.001). Conclusions: ERA patients had more symmetric joint involvement than PA; laboratory markers could be also an alternative where there is high RF and anti-CCP positivity with antibody levels among the ERA patients. Finally, the demographic features can be used as differentiating

Published
2014

9. Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis.

Author

Oztuzcu S, Onat AM, Pehlivan Y, Alibaz-Oner F, Donmez S, Cetin GY, Yolbas S, Bozgeyik I, Yilmaz N, Ozgen M, Cagatay Y, Kisacik B, Koca SS, Pamuk ON, Sayarlioglu M, Direskeneli H, and Demiryurek AT

Subjects
Adult, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Scleroderma, Systemic pathology, Turkey, Genetic Association Studies, Scleroderma, Systemic genetics, TRPM Cation Channels genetics
Abstract

Background/aim: Systemic sclerosis (SSc) is an inflammatory disease characterized by vascular abnormalities and fibrosis. The aim of the present study was to investigate the possible role of transient receptor potential melastatin (TRPM) channel genes in the susceptibility and phenotype expression of SSc., Materials and Methods: A total of 339 patients with SSc and 302 healthy controls were studied. Genomic DNA was extracted from leukocytes of the peripheral blood, and 25 single nucleotide polymorphisms in the TRPM channel genes were analyzed by the BioMark HD dynamic array system., Results: There were marked increases in the CC genotype (94.7% vs 81.8%, p<0.0001) and C allele frequencies (97.0% vs. 90.1%, p<0.0001) in the TRPM3 rs1328142, and TT genotype (19.0% vs. 7.8%, p=0.0002) in TRPM5 rs34551253 (Ala456Thr) polymorphism in SSc patients when compared to controls. TRPM3 gene rs1328142 polymorphism was also markedly associated with disease phenotype. However, no associations with the other 23 polymorphisms studied were found., Conclusion: This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of SSc in the Turkish population., (Copyright © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

10. Impact of rheumatoid arthritis in Turkey: a questionnaire study.

Author

Direskeneli H, Akkoç N, Bes C, Cakir N, Cefle A, Cobankara V, Dalkilic E, Dinc A, Ertenli I, Gul A, Hamuryudan V, Inanc M, Kalyoncu U, Karaaslan Y, Kasifoglu T, Keser G, Keskin G, Kisacik B, Kiraz S, Masatlioglu S, Onat AM, Ozbek S, Ozturk MA, Pamuk ON, Pay S, Pirildar T, Sayarlioglu M, Senel S, Senturk T, Tasan D, Terzioglu E, Yazici A, and Yucel E

Subjects
Adult, Antirheumatic Agents administration & dosage, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid psychology, Biological Products administration & dosage, Biological Products adverse effects, Communication, Drug Administration Schedule, Female, Health Care Surveys, Health Services Needs and Demand, Humans, Male, Middle Aged, Needs Assessment, Patient Preference, Patient Satisfaction, Perception, Severity of Illness Index, Surveys and Questionnaires, Time Factors, Treatment Outcome, Turkey, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Attitude of Health Personnel, Biological Products therapeutic use, Health Knowledge, Attitudes, Practice, Patients psychology, Physician-Patient Relations, Quality of Life
Abstract

Objectives: Unmet needs of rheumatoid arthritis (RA) patients regarding physician/patient communication, treatment preferences and quality of life issues were investigated in a Turkish survey study., Methods: The study was conducted with the contribution of 33 rheumatologists, and included 519 RA patients. The study population included patients who had been on biologic therapy for >6 months and were still receiving biologic therapy (BT group), and those who were biologic naive, but found eligible for biologic treatment (NBT group). Of the RA patients, 35.5% initially had a visit to an internal disease specialist, 25.5% to a physical therapy and rehabilitation specialist, and 12.2% to a rheumatology specialist for their RA complaints. The diagnosis of RA was made by a rheumatologist in 48.2% of patients., Results: The majority of RA patients (86.3%) visit their doctor within 15-week intervals. Most of the physician-patient communication focused on disease symptoms (99.0%) and impact of the disease on quality of life (61.8%). The proportion of RA patients who perceived their health status as good/very good/excellent was higher in the BT group than in the NBT group (74.3% vs. 51.5%, p<0.001). However, of those RA patients in the NBT group, only 24.8% have been recommended to start a biologic treatment by their doctors. With respect to dose frequency options, once-monthly injections were preferred (80%) to a bi-weekly injection schedule (8%)., Conclusions: In conclusion, RA patients receiving biologic therapy reported higher rates of improved symptoms and better quality of life and seemed to be more satisfied with their treatment in our study.

Published
2014

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