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2. Discovery of tau neutrino appearance in the CNGS neutrino beam with the OPERA experiment

Author

OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bodnarchuk, I., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fornari, F., Fukuda, T., Galati, G., Garfagnini, A., Goldberg, J., Gornushkin, Y., Grella, G., Guler, A. M., Gustavino, C., Hagner, C., Hara, T., Hayakawa, H., Hollnagel, A., Hosseini, B., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Laudisio, F., Lauria, A., Ljubicic, A., Longhin, A., Loverre, P. F., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matsushita, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Miyanishi, M., Mizutani, F., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Olchevsky, A., Omura, T., Ozaki, K., Paoloni, A., Paparella, L., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Schmidt-Parzefall, W., Shakirianova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Sotnikov, A., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladymyrov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., and Zemskova, S.

Subjects
High Energy Physics - Experiment
Abstract

The OPERA experiment was designed to search for $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations in appearance mode, i.e. by detecting the $\tau$-leptons produced in charged current $\nu_{\tau}$ interactions. The experiment took data from 2008 to 2012 in the CERN Neutrinos to Gran Sasso beam. The observation of $\nu_{\mu} \rightarrow \nu_{\tau}$ appearance, achieved with four candidate events in a sub-sample of the data, was previously reported. In this paper, a fifth $\nu_{\tau}$ candidate event, found in an enlarged data sample, is described. Together with a further reduction of the expected background, the candidate events detected so far allow assessing the discovery of $\nu_{\mu}\rightarrow \nu_{\tau}$ oscillations in appearance mode with a significance larger than 5 $\sigma$., Comment: 7 pages, 3 figures

Published
2015
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3. Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam

Author

OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bodnarchuk, I., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Goldberg, J., Gornushkin, Y., Grella, G., Guler, A. M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Ljubicic, A., Longhin, A., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Omura, T., Ozaki, K., Paoloni, A., Paparella, L., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakirianova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladymyrov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., and Zemskova, S.

Subjects
High Energy Physics - Experiment
Abstract

The OPERA experiment, exposed to the CERN to Gran Sasso $\nu_\mu$ beam, collected data from 2008 to 2012. Four oscillated $\nu_\tau$ Charged Current interaction candidates have been detected in appearance mode, which are consistent with $\nu_\mu \to \nu_\tau$ oscillations at the atmospheric $\Delta m^2$ within the "standard" three-neutrino framework. In this paper, the OPERA $\nu_\tau$ appearance results are used to derive limits on the mixing parameters of a massive sterile neutrino., Comment: 11 pages, 4 figures; reference to Planck result updated in the Introduction. Submitted to JHEP

Published
2015
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4. Observation of nu_tau appearance in the CNGS beam with the OPERA experiment

Author

OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buttne, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hayakawa, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawada, J., Kawahara, H., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malenica, M., Malgin, A., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Meyer, M., Mikado, S., Miyanishi, M., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Umemoto, A., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yaguchi, I., Yoshimoto, M., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment
Abstract

The OPERA experiment is searching for nu_mu -> nu_tau oscillations in appearance mode i.e. via the direct detection of tau leptons in nu_tau charged current interactions. The evidence of nu_mu -> nu_tau appearance has been previously reported with three nu_tau candidate events using a sub-sample of data from the 2008-2012 runs. We report here a fourth nu_tau candidate event, with the tau decaying into a hadron, found after adding the 2012 run events without any muon in the final state to the data sample. Given the number of analysed events and the low background, nu_mu -> nu_tau oscillations are established with a significance of 4.2sigma., Comment: Submitted to Progress of Theoretical and Experimental Physics (PTEP)

Published
2014
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5. Determination of the muon charge sign with the dipolar spectrometers of the OPERA experiment

Author

OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Goloubkov, D., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Meyer, M., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Rostovtseva, I., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zaitsev, Y., Zemskova, S., and Zghiche, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The OPERA long-baseline neutrino-oscillation experiment has observed the direct appearance of $\nu_\tau$ in the CNGS $\nu_\mu$ beam. Two large muon magnetic spectrometers are used to identify muons produced in the $\tau$ leptonic decay and in $\nu_\mu^{CC}$ interactions by measuring their charge and momentum. Besides the kinematic analysis of the $\tau$ decays, background resulting from the decay of charmed particles produced in $\nu_\mu^{CC}$ interactions is reduced by efficiently identifying the muon track. A new method for the charge sign determination has been applied, via a weighted angular matching of the straight track-segments reconstructed in the different parts of the dipole magnets. Results obtained for Monte Carlo and real data are presented. Comparison with a method where no matching is used shows a significant reduction of up to 40\% of the fraction of wrongly determined charges., Comment: 10 pages. Improvements in the text

Published
2014

6. Procedure for short-lived particle detection in the OPERA experiment and its application to charm decays

Author

Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Gollnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment
Abstract

The OPERA experiment, designed to perform the first observation of $\nu_\mu \rightarrow \nu_\tau$ oscillations in appearance mode through the detection of the $\tau$ leptons produced in $\nu_\tau$ charged current interactions, has collected data from 2008 to 2012. In the present paper, the procedure developed to detect $\tau$ particle decays, occurring over distances of the order of 1 mm from the neutrino interaction point, is described in detail. The results of its application to the search for charmed hadrons are then presented as a validation of the methods for $\nu_\tau$ appearance detection.

Published
2014
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7. Measurement of TeV atmospheric muon charge ratio with the full OPERA data

Author

Agafonova, N., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Buettner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment
Abstract

The OPERA detector, designed to search for $\nu_{\mu} \to \nu_{\tau}$ oscillations in the CNGS beam, is located in the underground Gran Sasso laboratory, a privileged location to study TeV-scale cosmic rays. For the analysis here presented, the detector was used to measure the atmospheric muon charge ratio in the TeV region. OPERA collected charge-separated cosmic ray data between 2008 and 2012. More than 3 million atmospheric muon events were detected and reconstructed, among which about 110000 multiple muon bundles. The charge ratio $R_{\mu} \equiv N_{\mu^+}/N_{\mu^-}$ was measured separately for single and for multiple muon events. The analysis exploited the inversion of the magnet polarity which was performed on purpose during the 2012 Run. The combination of the two data sets with opposite magnet polarities allowed minimizing systematic uncertainties and reaching an accurate determination of the muon charge ratio. Data were fitted to obtain relevant parameters on the composition of primary cosmic rays and the associated kaon production in the forward fragmentation region. In the surface energy range 1-20 TeV investigated by OPERA, $R_{\mu}$ is well described by a parametric model including only pion and kaon contributions to the muon flux, showing no significant contribution of the prompt component. The energy independence supports the validity of Feynman scaling in the fragmentation region up to $200$ TeV/nucleon primary energy., Comment: 8 pages, 2 figures, 4 tables

Published
2014
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8. Evidence for $\nu_\mu \to \nu_\tau$ appearance in the CNGS neutrino beam with the OPERA experiment

Author

Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Autiero, D., Dhahbi, A. Ben, Badertscher, A., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Brunet, F., Brunetti, G., Buonaura, A., Buontempo, S., Buettner, B., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. Del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Favier, J., Ferber, T., Ferone, G., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, M., Gustavino, C., Hagner, C., Hakamata, K., Hara, T., Hayakawa, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Ishikawa, M., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawada, J., Kawahara, H., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Miyanishi, M., Miyashita, E., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Rostovtseva, I., Rubbia, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefal, W., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Yoshimoto, M., Zaitsev, Y., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The OPERA experiment is designed to search for $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations in appearance mode i.e. through the direct observation of the $\tau$ lepton in $\nu_{\tau}$ charged current interactions. The experiment has taken data for five years, since 2008, with the CERN Neutrino to Gran Sasso beam. Previously, two $\nu_{\tau}$ candidates with a $\tau$ decaying into hadrons were observed in a sub-sample of data of the 2008-2011 runs. Here we report the observation of a third $\nu_\tau$ candidate in the $\tau^-\to\mu^-$ decay channel coming from the analysis of a sub-sample of the 2012 run. Taking into account the estimated background, the absence of $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillations is excluded at the 3.4 $\sigma$ level., Comment: 9 pages, 5 figures, 1 tables

Published
2014
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9. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

Author

Omura, T, Omura, K, Tedeschi, A, Riva, P, Painter, MW, Rojas, L, Martin, J, Lisi, V, Huebner, EA, Latremoliere, A, Yin, Y, Barrett, LB, Singh, B, Lee, S, Crisman, T, Gao, F, Li, S, Kapur, K, Geschwind, DH, Kosik, KS, Coppola, G, He, Z, Carmichael, ST, Benowitz, LI, Costigan, M, and Woolf, CJ

Subjects
Neurology & Neurosurgery, Neurosciences, Cognitive Sciences, Psychology
Abstract

Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability. Omura et al. screened for neuronal growth on myelin and find CAST/Ei inbred mice are uniquely able to regenerate axons in the injured CNS through Activin signaling. Enhancing Activin signaling confers a CNS-regenerative capacity in normally non-regenerative mouse strains.

Published
2015

10. New results on $\nu_\mu \to \nu_\tau$ appearance with the OPERA experiment in the CNGS beam

Author

OPERA Collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Asada, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Brunetti, G., Buettner, B., Buontempo, S., Chaussard, L., Chernyavskiy, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., Sanchez, P. Del Amo, De Lellis, G., De Serio, M., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Ebert, J., Ereditato, A., Favier, J., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, A. M., Gustavino, C., Hagner, C., Hakamata, K., Hara, T., Hayakawa, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Ishikawa, M., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Katsuragawa, T., Kawahara, H., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Migliozzi, P., Mikado, S., Minotti, A., Miyanishi, M., Miyashita, E., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schembri, A., Schmidt-Parzefall, W., Shakiryanova, I., Schcedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Yoshimoto, M., Zaitsev, Y., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The OPERA neutrino experiment is designed to perform the first observation of neutrino oscillations in direct appearance mode in the $\nu_\mu \to \nu_\tau$ channel, via the detection of the $\tau$-leptons created in charged current $\nu_\tau$ interactions. The detector, located in the underground Gran Sasso Laboratory, consists of an emulsion/lead target with an average mass of about 1.2 kt, complemented by electronic detectors. It is exposed to the CERN Neutrinos to Gran Sasso beam, with a baseline of 730 km and a mean energy of 17 GeV. The observation of the first $\nu_\tau$ candidate event and the analysis of the 2008-2009 neutrino sample have been reported in previous publications. This work describes substantial improvements in the analysis and in the evaluation of the detection efficiencies and backgrounds using new simulation tools. The analysis is extended to a sub-sample of 2010 and 2011 data, resulting from an electronic detector-based pre-selection, in which an additional $\nu_\tau$ candidate has been observed. The significance of the two events in terms of a $\nu_\mu \to \nu_\tau$ oscillation signal is of 2.40 $\sigma$., Comment: 33 pages, 12 figures, 5 tables. Prepared for submission to JHEP

Published
2013

11. Search for $\nu_\mu \rightarrow \nu_e$ oscillations with the OPERA experiment in the CNGS beam

Author

OPERA collaboration, Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Autiero, D., Badertscher, A., Dhahbi, A. Ben, Bertolin, A., Bozza, C., Brugnera, R., Brunet, F., Brunetti, G., Buettner, B., Buontempo, S., Chaussard, L., Chernyavsky, M., Chiarella, V., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Sanchez, P. del Amo, Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievsky, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Ferber, T., Fini, R. A., Fukuda, T., Garfagnini, A., Giacomelli, G., Goellnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Grianti, F., Guler, A. M., Gustavino, C., Hagner, C., Hamada, K., Hara, T., Hierholzer, M., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Juget, F., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J. H., Kim, S. H., Kimura, M., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Mancini-Terracciano, C., Mandrioli, G., Marteau, J., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meisel, F. W., Meregaglia, A., Migliozzi, P., Mikado, S., Minotti, A., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Nakamura, M., Nakano, T., Nakatsuka, Y., Naumov, D., Niwa, K., Ogawa, S., Okateva, N., Olchevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B. D., Park, I. G., Pastore, A., Patrizii, L., Pennacchio, E., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pretzl, K., Pupilli, F., Rescigno, R., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Rostovtseva, I., Rubbia, A., Russo, A., Ryazhskaya, O., Sato, O., Sato, Y., Schchedrina, T., Schembri, A., Schmidt-Parzefall, W., Shakiryanova, I., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strauss, T., Strolin, P., Suzuki, K., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tolun, P., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J. -L., Wilquet, G., Wonsak, B., Yoon, C. S., Yoshida, J., Zaitsev, Y., Zemskova, S., and Zghiche, A.

Subjects
High Energy Physics - Experiment
Abstract

A first result of the search for \numu $\rightarrow$ \nue oscillations in the OPERA experiment, located at the Gran Sasso Underground Laboratory, is presented. The experiment looked for the appearance of \nue in the CNGS neutrino beam using the data collected in 2008 and 2009. Data are compatible with the non-oscillation hypothesis in the three-flavour mixing model. A further analysis of the same data constrains the non-standard oscillation parameters $\theta_{new}$ and $\Delta m^2_{new}$ suggested by the LSND and MiniBooNE experiments. For large $\Delta m^{2}_{new}$ values ($>$0.1 eV$^{2}$), the OPERA 90% C.L. upper limit on sin$^{2}(2\theta_{new})$ based on a Bayesian statistical method reaches the value $7.2 \times 10^{-3}$.

Published
2013

14. The OPERA experiment

Author

Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Del Amo Sanchez, P., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R.A., Fukuda, T., Galati, G., Garfagnini, A., Giacomelli, G., Göllnitz, C., Goldberg, J., Gornushkin, Y., Grella, G., Guler, M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishida, H., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kawada, J., Kim, J.H., Kim, S.H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Lenkeit, J., Ljubicic, A., Longhin, A., Loverre, P., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M.C., Morishima, K., Muciaccia, M.T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Okateva, N., Olshevsky, A., Omura, T., Ozaki, K., Paoloni, A., Park, B.D., Park, I.G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Pistillo, C., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Rokujo, H., Roganova, T., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakiryanova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S.M., Stipcevic, M., Strauss, T., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladimirov, M., Votano, L., Vuilleumier, J.L., Wilquet, G., Wonsak, B., Yoon, C.S., Zemskova, S., and Zghiche, A.

Published
2015
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15. Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

Author

Cronin, SJF, Rao, S, Tejada, MA, Turnes, BL, Licht-Mayer, S, Omura, T, Brenneis, C, Jacobs, E, Barrett, L, Latremoliere, A, Andrews, N, Channon, KM, Latini, A, Arvanites, AC, Davidow, LS, Costigan, M, Rubin, LL, Penninger, JM, and Woolf, CJ

Subjects
ErbB Receptors, Proto-Oncogene Proteins p21(ras), Analgesics, Mice, Lung Neoplasms, Animals, Humans, Neuralgia, General Medicine, GTP Cyclohydrolase, Biopterin, Article
Abstract

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads to both reduced BH4 and pain. However, little is known about the regulation of Gch1 expression upon nerve injury and whether this could be modulated as an analgesic therapeutic intervention. We performed a phenotypic screen using about 1000 bioactive compounds, many of which are target-annotated FDA-approved drugs, for their effect on regulating Gch1 expression in rodent injured dorsal root ganglion neurons. From this approach, we uncovered relevant pathways that regulate Gch1 expression in sensory neurons. We report that EGFR/KRAS signaling triggers increased Gch1 expression and contributes to neuropathic pain; conversely, inhibiting EGFR suppressed GCH1 and BH4 and exerted analgesic effects, suggesting a molecular link between EGFR/KRAS and pain perception. We also show that GCH1/BH4 acts downstream of KRAS to drive lung cancer, identifying a potentially druggable pathway. Our screen shows that pharmacologic modulation of GCH1 expression and BH4 could be used to develop pharmacological treatments to alleviate pain and identified a critical role for EGFR-regulated GCH1/BH4 expression in neuropathic pain and cancer in rodents.

Published
2022

16. Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam

Author

Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bodnarchuk, I., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavsky, M., Chukanov, A., Consiglio, L., D’Ambrosio, N., De Lellis, G., De Serio, M., Del Amo Sanchez, P., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fukuda, T., Galati, G., Garfagnini, A., Goldberg, J., Gornushkin, Y., Grella, G., Guler, A. M., Gustavino, C., Hagner, C., Hara, T., Hollnagel, A., Hosseini, B., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kim, J. H., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Lauria, A., Ljubicic, A., Longhin, A., Malgin, A., Malenica, M., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Nakatsuka, Y., Niwa, K., Ogawa, S., Omura, T., Ozaki, K., Paoloni, A., Paparella, L., Park, B. D., Park, I. G., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakirianova, I., Shchedrina, T., Sheshukov, A., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Tufanli, S., Vilain, P., Vladymyrov, M., Votano, L., Vuilleumier, J. L., Wilquet, G., Wonsak, B., Yoon, C. S., Zemskova, S., and The OPERA collaboration

Published
2015
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25. Development of a position-sensitive detector for TOF-PET

Author

Moriya, T., Omura, T., Watanabe, M., and Yamashita, T.

Subjects
PET imaging -- Equipment and supplies, Photoelectric multipliers -- Usage, Photoelectric multipliers -- Properties, Crystals -- Properties, Business, Electronics, Electronics and electrical industries
Abstract

A position-sensitive detector (PS-detector) for a time-of-flight (TOF) PET system has been developed and evaluated. The PS-detector consists of a flat panel position-sensitive photomultiplier tube (PS-PMT; Hamamatsu R8400-00-M64 MOD) and 2.9 mm x 2.9 mm x 20 mm LYSO crystals arranged in a 16 x 16 array. The PS-PMT has eight stages of metal channel dynode and 8 x 8 multiple anodes in a 52.0 mm square x 14.8 mm high metal can package. In order to compensate for the non-uniform amplitude from the multiple anodes of the PS-PMT, an application specific integrated circuit (ASIC) having 64-channel variable gain amplifiers is attached to the front-end circuits. The ASIC also has a readout circuit to reduce 64-channel outputs down to four position signals and an energy signal. The performance of PS-detector was evaluated for TOF-PET application. The coincidence response functions (CRFs) were measured by scanning a [sup.22]Na point source with 0.4 mm steps across the center of a pair of the PS-detectors. The average FWHM value of the CRFs is 2.3 mm. The energy resolution corresponding to each crystal element at 511 keV is 10.9% on the average. The timing resolutions of the PS-detector at FWHM, with a Ba[F.sub.2] reference detector, range from 421 ps to 787 ps, with an average of 505 ps. A new PS-PMT having high QE is now under development. The timing resolutions of the new PS-PMT coupled to a La[Br.sub.3] and a LYSO single crystal are 236 ps FWHM and 366 ps FWHM, respectively, with a Ba[F.sub.2] reference detector. We are developing a new TOF-PET system with PS-detectors. Index Terms--Positron emission tomography (PET), position sensitive PMT, time-of-flight PET.

Published
2008

26. Development of a small animal PET scanner using DOI detectors

Author

Yamada, R., Watanabe, M., Omura, T., Sato, N., Shimizu, K., Takahashi, M., Ote, K., Katabe, A., Moriya, T., Sakai, K., Yamashita, T., and Tanaka, E.

Subjects
PET imaging -- Methods, Image processing -- Technology application, Image processing -- Equipment and supplies, Imaging systems -- Design and construction, Imaging technology, Technology application, Business, Electronics, Electronics and electrical industries
Abstract

A small animal PET scanner using 256-channel PS-PMTs has been designed, constructed, and evaluated. The scanner has twelve detector modules, each of which consists of a double-layer array of LYSO crystals and three PS-PMTs (Hamamatsu R8400-00-M256). In the LYSO crystal block, 32 x 53 crystal elements are optically coupled to 32 x 54 crystal elements with a shift of half the element pitch in the axial direction. The dimension of each crystal element is 1.275 x 2.675 [mm.sup.2] in cross section and 7 mm in depth. The twelve detector modules are positioned on a 182 mm diameter ring to form 107 detector rings with 1.4 nun pitch. The trausaxial FOV is 100 mm in diameter and the axial FOV is 151 mm, which is sufficient to cover the whole body of a mouse. In order to compensate for non-uniform outputs from the multi-anodes of the PS-PMTs, ASICs having 64-channel variable gain amplifiers and summing amplifiers are used in the front-end circuits. The preliminary experimental results are the transaxial resolution of 2.0 mm FWHM in the CFOV, and the axial resolution of 2.8 mm FWHM on the axis of the ring. The absolute coincidence sensitivity is 8.1% for a point source at the CFOV with setting an energy window of 350-750 keV and a timing window of 10 us. The applicable imaging capability of the scanner was demonstrated by animal studies with a rat. Index Terms--Depth of interaction (DOI), positron emission tomography (PET), position sensitive PMT, small animal imaging.

Published
2008

28. The key clinical symptoms that differentiates cervical radiculopathy from cubital tunnel syndrome

Author

Ogawa, T, Omura, T, Hasegawa, T, and Matsuyama, Y

Subjects
ddc: 610, cubital tunnel syndrome, cervical radiculopathy, 610 Medical sciences, Medicine
Abstract

Objectives/Interrogation: Ulnar nerve is supplied by fibers originating from C8, T1 roots and it is sometimes difficult to differentiate cubital tunnel syndrome (CuTS) from C8 radiculopathy. The purpose of this study was to retrospectively review cases of C8 radiculopathy that were referred to [for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

Published
2020
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39. A high-throughput whole-body PET scanner using flat panel PS-PMTs

Author

Watanabe, M., Shimizu, K., Omura, T., Sato, N., Takahashi, M., Kosugi, T., Ote, K., Katabe, A., Yamada, R., Yamashita, T., and Tanaka, E.

Subjects
Nuclear physics -- Research, Business, Electronics, Electronics and electrical industries
Abstract

A new positron emission tomography (PET) scanner for whole-body studies has been developed. The scanner has 720 block detectors, each of which consists of a flat panel position-sensitive photomultiplier and a 16 x 8 BGO crystal array. The detector system is composed of 12 layers of block detector rings stacked axially, and each ring consists of a circular array of 60 block detectors. Since each block detector ring contains eight crystal rings, the total number of detector rings is 96 and the axial field of view (FOV) is 685 mm, which is sufficient to measure a whole-body with two steps of scan. The detector ring diameter is 1 020 mm and the transaxial FOV is 600 mm in diameter. Coarse slice septa are placed between the block detector rings, which are effective to reduce scattered coincidence events while keeping a high detection sensitivity. Parallel 16 personal computers are used for the data acquisition and processing to deal with a large amount of event data. The acquired data in 3-D manner are converted to 2-D data set with Fourier rebinning algorithm and reconstructed with a fast iterarive algorithm 'DRAMA'. The reconstructed images for the whole body are obtained within 5 min after the scan. By using the coarse septa, the scatter fraction measured with NEMA NU2-2001 standard was 31.4% whose value was significantly lower than that of 3-D PET without septa. The system sensitivity was 9.72 cps/kBq, and the peak counts of the noise equivalent count rate used with direct random-subtraction was 113.6 keps at 10.5 kBq/ml. Index Terms--High-throughput, position sensitive PMT, positron emission tomography (PET), whole-body scan.

Published
2004

44. A new high-resolution PET scanner dedicated to brain research

Author

Watanabe, M., Shimizu, K., Omura, T., Takahashi, M., Kosugi, T., Yoshikawa, E., Sato, N., Okada, H., and Yamashita, T.

Subjects
PET imaging -- Evaluation, Detectors -- Design and construction, Brain -- Medical examination, Business, Electronics, Electronics and electrical industries
Abstract

A high-resolution positron emission tomography (PET) scanner dedicated to brain studies has been developed and its physical performance was evaluated. The block detector consists of a new compact position-sensitive photomultiplier tube (PS-PMT, Hamamatsu R7600-C12) and an 8 x 4 bismuth germanate (BGO) array. The size of each crystal is 2.8 mm x 6.55 mm x 30 mm. The system has a total of 11 520 crystals arranged in 24 detector rings 508 mm in diameter (480 per ring). The field of view (FOV) is 330 mm in diameter x 163 mm, which is sufficient to measure the entire human brain. The diameter of the scanner's opening is equal to the transaxial FOV (330 mm). The system can be operated in three-dimensional (3-D) data acquisition mode, when the slice septa are retracted. The mechanical motions of the gantry and bed are specially designed to measure the patient in various postures; lying, sitting, and even standing postures. The spatial resolution of 2.9 mm in both the transaxial and axial directions is obtained at the center of the FOV. The total system sensitivity is 6.4 kc/s/kBq/ml in two-dimensional (2-D) mode, with a 20-cm-diameter cylindrical phantom. The imaging capabilities of the scanner were studied with the Hoffman brain phantom and with a normal volunteer. Index Terms--Instrumentation, performance measurements, positron emission tomography (PET).

Published
2002

45. More results from the OPERA experiment

Author

Galati, G., Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bodnarchuk, I., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavskiy, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Del Amo Sanchez, P., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., A.Fini, R., Fornari, F., Fukuda, T., Garfagnini, A., Goldberg, J., Gornushkin, Y., Grella, G., M.Guler, A., Gustavino, C., Hagner, C., Hara, T., Hayakawa, H., Hollnagel, A., Hosseini, B., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., H.Kim, S., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Laudisio, F., Lauria, A., Ljubicic, A., Longhin, A., F.Loverre, P., Malenica, M., Malgin, A., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Miyanishi, M., Mizutani, F., Monacelli, P., C.Montesi, M., Morishima, K., T.Muciaccia, M., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Niwa, K., Ogawa, S., Omura, T., Osaki, K., Paoloni, A., Paparella, L., D.Park, B., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakirianova, I., Shchedrina, T., Sheshukov, A., Shibayama, E., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sirignano, C., Sirri, G., Sotnikov, A., Spinetti, M., Stanco, L., Starkov, N., M.Stellacci, S., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Vasina, S., Vilain, P., Voevodina, E., Votano, L., L.Vuilleumier, J., Wilquet, G., S.Yoon, C., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Galati, G, Agafonova, N, Aleksandrov, A, Anokhina, A, Aoki, S, Ariga, A, Ariga, T, Bender, D, Bertolin, A, Bodnarchuk, I, Bozza, C, Brugnera, R, Buonaura, A, Buontempo, S, Büttner, B, Chernyavskiy, M, Chukanov, A, Consiglio, L, D'Ambrosio, N, De Lellis, G, De Serio, M, Del Amo Sanchez, P, Di Crescenzo, A, Di Ferdinando, D, Di Marco, N, Dmitrievski, S, Dracos, M, Duchesneau, D, Dusini, S, Dzhatdoev, T, Ebert, J, Ereditato, A, Fini, R, Fornari, F, Fukuda, T, Garfagnini, A, Goldberg, J, Gornushkin, Y, Grella, G, Guler, A, Gustavino, C, Hagner, C, Hara, T, Hayakawa, H, Hollnagel, A, Hosseini, B, Ishiguro, K, Jakovcic, K, Jollet, C, Kamiscioglu, C, Kamiscioglu, M, Kim, S, Kitagawa, N, Klicek, B, Kodama, K, Komatsu, M, Kose, U, Kreslo, I, Laudisio, F, Lauria, A, Ljubicic, A, Longhin, A, Loverre, P, Malenica, M, Malgin, A, Mandrioli, G, Matsuo, T, Matveev, V, Mauri, N, Medinaceli, E, Meregaglia, A, Mikado, S, Miyanishi, M, Mizutani, F, Monacelli, P, Montesi, M, Morishima, K, Muciaccia, M, Naganawa, N, Naka, T, Nakamura, M, Nakano, T, Niwa, K, Ogawa, S, Omura, T, Osaki, K, Paoloni, A, Paparella, L, Park, B, Pasqualini, L, Pastore, A, Patrizii, L, Pessard, H, Podgrudkov, D, Polukhina, N, Pozzato, M, Pupilli, F, Roda, M, Roganova, T, Rokujo, H, Rosa, G, Ryazhskaya, O, Sato, O, Schembri, A, Shakirianova, I, Shchedrina, T, Sheshukov, A, Shibayama, E, Shibuya, H, Shiraishi, T, Shoziyoev, G, Simone, S, Sirignano, C, Sirri, G, Sotnikov, A, Spinetti, M, Stanco, L, Starkov, N, Stellacci, S, Stipcevic, M, Strolin, P, Takahashi, S, Tenti, M, Terranova, F, Tioukov, V, Vasina, S, Vilain, P, Voevodina, E, Votano, L, Vuilleumier, J, Wilquet, G, Yoon, C, Galati, G., Agafonova, N., Aleksandrov, A., Anokhina, A., Aoki, S., Ariga, A., Ariga, T., Bender, D., Bertolin, A., Bodnarchuk, I., Bozza, C., Brugnera, R., Buonaura, A., Buontempo, S., Büttner, B., Chernyavskiy, M., Chukanov, A., Consiglio, L., D'Ambrosio, N., De Lellis, G., De Serio, M., Del Amo Sanchez, P., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dmitrievski, S., Dracos, M., Duchesneau, D., Dusini, S., Dzhatdoev, T., Ebert, J., Ereditato, A., Fini, R. A., Fornari, F., Fukuda, T., Garfagnini, A., Goldberg, J., Gornushkin, Y., Grella, G., Guler, A. M., Gustavino, C., Hagner, C., Hara, T., Hayakawa, H., Hollnagel, A., Hosseini, B., Ishiguro, K., Jakovcic, K., Jollet, C., Kamiscioglu, C., Kamiscioglu, M., Kim, S. H., Kitagawa, N., Klicek, B., Kodama, K., Komatsu, M., Kose, U., Kreslo, I., Laudisio, F., Lauria, A., Ljubicic, A., Longhin, A., Loverre, PIER FERRUCCIO, Malenica, M., Malgin, A., Mandrioli, G., Matsuo, T., Matveev, V., Mauri, N., Medinaceli, E., Meregaglia, A., Mikado, S., Miyanishi, M., Mizutani, F., Monacelli, P., Montesi, M. C., Morishima, K., Muciaccia, M. T., Naganawa, N., Naka, T., Nakamura, M., Nakano, T., Niwa, K., Ogawa, S., Omura, T., Osaki, K., Paoloni, A., Paparella, L., Park, B. D., Pasqualini, L., Pastore, A., Patrizii, L., Pessard, H., Podgrudkov, D., Polukhina, N., Pozzato, M., Pupilli, F., Roda, M., Roganova, T., Rokujo, H., Rosa, G., Ryazhskaya, O., Sato, O., Schembri, A., Shakirianova, I., Shchedrina, T., Sheshukov, A., Shibayama, E., Shibuya, H., Shiraishi, T., Shoziyoev, G., Simone, S., Sirignano, C., Sirri, G., Sotnikov, A., Spinetti, M., Stanco, L., Starkov, N., Stellacci, S. M., Stipcevic, M., Strolin, P., Takahashi, S., Tenti, M., Terranova, F., Tioukov, V., Vasina, S., Vilain, P., Voevodina, E., Votano, L., Vuilleumier, J. L., Wilquet, G., Yoon, C. S., Fini, R.A., Guler, A.M., Kim, S.H., Loverre, P.F., Montesi, M.C., Muciaccia, M.T., Park, B.D., Stellacci, S.M., Vuilleumier, J.L., and Yoon, C.S.

Subjects
Physics and Astronomy (miscellaneous), OPERA, neutrino: mass difference, Astronomy and Astrophysics, Astronomy and Astrophysic, neutrino: mixing angle, neutrino/mu: secondary beam, Gran Sasso, muon: cosmic radiation, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], neutrino/tau: particle identification, neutrino: oscillation, talk: La Thuile 2017/03/05, neutrino: mixing, experimental results
Abstract

International audience; The OPERA experiment reached its main goal by proving the appearance of ντ in the CNGS νμ beam. Five ντ candidates were detected with a S/B ratio of ∼ 10, allowing to reject the null hypothesis at 5.1σ. The search has been extended by loosening the selection criteria in order to improve the statistical uncertainty. One of the ντ candidates selected with the new strategy shows a double vertex topology and, after a dedicated multivariate analysis, is compatible with being a ντ interaction with charm production. Based on the enlarged data sample the estimation of Δm2 23 in appearance mode is being performed. The search for νe interactions has been extended over the full data set with a more than twofold increase in statistics: data are compatible with the non-oscillation hypothesis in the three-flavour mixing model. The implications of the electron neutrino sample in the framework of the 3+1 sterile mode will lead to exclusion limits on sin2 2θμe. Finally, the analysis of the annual modulation of cosmic muons is introduced.

Published
2017

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