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1. Association of troponin level and age with mortality in 250 000 patients : cohort study across five UK acute care centres

Author

Kaura, Amit, Panoulas, Vasileios, Glampson, Benjamin, Davies, Jim, Mulla, Abdulrahim, Woods, Kerrie, Omigie, Joe, Shah, Anoop D, Channon, Keith M, Weber, Jonathan N, Thursz, Mark R, Elliott, Paul, Hemingway, Harry, Williams, Bryan, Asselbergs, Folkert, O’Sullivan, Michael, Kharbanda, Rajesh, Lord, Graham M, Melikian, Narbeh, Patel, Riyaz S, Perera, Divaka, Shah, Ajay M, Francis, Darrel P, and Mayet, Jamil

Published
2019

2. Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Author

Kaura, Amit, Hartley, Adam, Panoulas, Vasileios, Glampson, Ben, Shah, Anoop S. V., Davies, Jim, Mulla, Abdulrahim, Woods, Kerrie, Omigie, Joe, Shah, Anoop D., Thursz, Mark R., Elliott, Paul, Hemmingway, Harry, Williams, Bryan, Asselbergs, Folkert W., O'Sullivan, Michael, Lord, Graham M., Trickey, Adam, Sterne, Jonathan AC, Haskard, Dorian O., Melikian, Narbeh, Francis, Darrel P., Koenig, Wolfgang, Shah, Ajay M., Kharbanda, Rajesh, Perera, Divaka, Patel, Riyaz S., Channon, Keith M., Mayet, Jamil, and Khamis, Ramzi

Subjects
Mortality -- Risk factors, Acute coronary syndrome -- Prognosis -- Patient outcomes, C-reactive protein -- Measurement -- Health aspects, Biological sciences
Abstract

Background There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond troponin in a large real-world cohort of unselected patients presenting with suspected acute coronary syndrome (ACS) is unknown. We evaluated whether a mildly elevated hsCRP (up to 15 mg/L) was associated with mortality risk, beyond troponin level, in patients with suspected ACS. Methods and findings We conducted a retrospective cohort study based on the National Institute for Health Research Health Informatics Collaborative data of 257,948 patients with suspected ACS who had a troponin measured at 5 cardiac centres in the United Kingdom between 2010 and 2017. Patients were divided into 4 hsCRP groups ( Following the exclusion criteria, there were 102,337 patients included in the analysis (hsCRP 15 mg/L makes it unlikely that sepsis was a major contributor. Conclusions These multicentre, real-world data from a large cohort of patients with suspected ACS suggest that mildly elevated hsCRP (up to 15 mg/L) may be a clinically meaningful prognostic marker beyond troponin and point to its potential utility in selecting patients for novel treatments targeting inflammation. Trial registration ClinicalTrials.gov - NCT03507309, Author(s): Amit Kaura 1,2, Adam Hartley 1,2, Vasileios Panoulas 1,2, Ben Glampson 2, Anoop S. V. Shah 1,2,3, Jim Davies 4, Abdulrahim Mulla 2, Kerrie Woods 4, Joe Omigie 5, [...]

Published
2022
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3. Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data

Author

Kaura, Amit, primary, Sterne, Jonathan A C, additional, Trickey, Adam, additional, Abbott, Sam, additional, Mulla, Abdulrahim, additional, Glampson, Benjamin, additional, Panoulas, Vasileios, additional, Davies, Jim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith M, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W, additional, O'Sullivan, Michael, additional, Lord, Graham M, additional, Melikian, Narbeh, additional, Johnson, Thomas, additional, Francis, Darrel P, additional, Shah, Ajay M, additional, Perera, Divaka, additional, Kharbanda, Rajesh, additional, Patel, Riyaz S, additional, and Mayet, Jamil, additional

Published
2020
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4. Prognostic significance of troponin level in 3121 patients presenting with atrial fibrillation (The NIHR Health Informatics Collaborative TROP‐AF study)

Author

Kaura, Amit, primary, Arnold, Ahran D., additional, Panoulas, Vasileios, additional, Glampson, Benjamin, additional, Davies, Jim, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D., additional, Channon, Keith M., additional, Weber, Jonathan N., additional, Thursz, Mark R., additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W., additional, O'Sullivan, Michael, additional, Lord, Graham M., additional, Melikian, Narbeh, additional, Lefroy, David C., additional, Francis, Darrel P., additional, Shah, Ajay M., additional, Kharbanda, Rajesh, additional, Perera, Divaka, additional, Patel, Riyaz S., additional, and Mayet, Jamil, additional

Published
2020
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6. 69 The relationship between troponin level and mortality in an unselected population of over 250,000 patients with suspected acute coronary syndrome (NIHR Health Informatics Collaborative Trop-risk study)

Author

Kaura, Amit, primary, Panoulas, Vasileios, additional, Glampson, Ben, additional, Davies, Jim, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert, additional, O’Sullivan, Michael, additional, Lord, Graham, additional, Melikian, Narbeh, additional, Kharbanda, Rajesh, additional, Shah, Ajay, additional, Perera, Divaka, additional, Patel, Riyaz, additional, Francis, Daryl, additional, and Mayet, Jamil, additional

Published
2019
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7. 146 The prognostic implication of a positive troponin across the age spectrum in a quarter of a million patients with suspected acute coronary syndrome (NIHR Health Informatics Collaborative Trop-risk Study)

Author

Kaura, Amit, primary, Panoulas, Vasileios, additional, Glampson, Ben, additional, Davies, Jim, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert, additional, O’Sullivan, Michael, additional, Lord, Graham, additional, Melikian, Narbeh, additional, Kharbanda, Rajesh, additional, Shah, Ajay, additional, Perera, Divaka, additional, Patel, Riyaz, additional, Francis, Daryl, additional, and Mayet, Jamil, additional

Published
2019
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8. 145 The role of high-sensitivity C-reactive protein in predicting mortality beyond troponin in over 100,000 patients with suspected acute coronary syndrome (NIHR Health Informatics Collaborative CRP-risk Study)

Author

Kaura, Amit, primary, Hartley, Adam, additional, Panoulas, Vasileios, additional, Glampson, Ben, additional, Davies, Jim, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert, additional, O’Sullivan, Michael, additional, Haskard, Dorian, additional, Lord, Graham, additional, Melikian, Narbeh, additional, Francis, Daryl, additional, Koenig, Wolfgang, additional, Perera, Divaka, additional, Shah, Ajay, additional, Kharbanda, Rajesh, additional, Patel, Riyaz, additional, Mayet, Jamil, additional, and Khamis, Ramzi, additional

Published
2019
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9. 30 The prognostic implication of troponin level in over 3000 patients presenting with atrial fibrillation (NIHR Health Informatics Collaborative AF-trop Study)

Author

Kaura, Amit, primary, Arnold, Ahran, additional, Panoulas, Vasileios, additional, Glampson, Ben, additional, Davies, Jim, additional, Mulla, Abdulrahim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert, additional, O’Sullivan, Michael, additional, Lord, Graham, additional, Melikian, Narbeh, additional, Lefroy, David, additional, Francis, Daryl, additional, Shah, Ajay, additional, Perera, Divaka, additional, Kharbanda, Rajesh, additional, Patel, Riyaz, additional, and Mayet, Jamil, additional

Published
2019
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10. 57 Invasive versus medical management of elderly patients with non-ST elevation myocardial infarction (NIHR Health Informatics Collaborative Senior-NSTEMI study)

Author

Kaura, Amit, primary, Sterne, Jonathan, additional, Mulla, Abdulrahim, additional, Panoulas, Vasileios, additional, Glampson, Ben, additional, Davies, Jim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D, additional, Channon, Keith, additional, Weber, Jonathan N, additional, Thursz, Mark R, additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert, additional, O’Sullivan, Michael, additional, Lord, Graham, additional, Melikian, Narbeh, additional, Francis, Daryl, additional, Perera, Divaka, additional, Shah, Ajay, additional, Kharbanda, Rajesh, additional, Patel, Riyaz, additional, and Mayet, Jamil, additional

Published
2019
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11. A PROPENSITY MATCHED ANALYSIS OF INVASIVE VERSUS CONSERVATIVE MANAGEMENT OF ELDERLY PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION (SENIOR-NSTEMI STUDY)

Author

Kaura, Amit, primary, Mulla, Abdulrahim, additional, Panoulas, Vasileios, additional, Benjamin, Glampson, additional, Davies, Jim, additional, Woods, Kerrie, additional, Omigie, Joe, additional, Shah, Anoop D., additional, Channon, Keith, additional, Weber, Jonathan N., additional, Thursz, Mark R., additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W., additional, O'Sullivan, Michael, additional, Kharbanda, Rajesh, additional, Lord, Graham M., additional, Melikian, Narbeh, additional, Patel, Riyaz, additional, Perera, Divaka, additional, Shah, Ajay, additional, Francis, Darrel, additional, and Mayet, Jamil, additional

Published
2019
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12. UNEXPECTED INVERTED U-SHAPED RELATIONSHIP BETWEEN TROPONIN LEVEL AND MORTALITY EXPLAINED BY REVASCULARIZATION IN BOTH PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROME (TROP-RISK STUDY)

Author

Kaura, Amit, primary, Panoulas, Vasileios, additional, Glampson, Benjamin, additional, Davies, Jim, additional, Woods, Kerrie, additional, Mulla, Abdulrahim, additional, Omigie, Joe, additional, Shah, Anoop D., additional, Channon, Keith, additional, Weber, Jonathan N., additional, Thursz, Mark R., additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W., additional, O'Sullivan, Michael, additional, Kharbanda, Rajesh, additional, Lord, Graham M., additional, Melikian, Narbeh, additional, Patel, Riyaz, additional, Perera, Divaka, additional, Shah, Ajay, additional, Francis, Darrel, additional, and Mayet, Jamil, additional

Published
2019
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13. CLINICAL IMPORTANCE OF TROPONIN LEVEL IN 3,121 PATIENTS PRESENTING WITH ATRIAL FIBRILLATION (AF-TROP STUDY)

Author

Kaura, Amit, primary, Arnold, Ahran, additional, Panoulas, Vasileios, additional, Glampson, Benjamin, additional, Davies, Jim, additional, Woods, Kerrie, additional, Mulla, Abdulrahim, additional, Omigie, Joe, additional, Shah, Anoop D., additional, Channon, Keith, additional, Weber, Jonathan N., additional, Thursz, Mark R., additional, Elliott, Paul, additional, Hemingway, Harry, additional, Williams, Bryan, additional, Asselbergs, Folkert W., additional, Kharbanda, Rajesh, additional, Lord, Graham M., additional, Melikian, Narbeh, additional, Patel, Riyaz, additional, Perera, Divaka, additional, Shah, Ajay, additional, Lefroy, David, additional, Francis, Darrel, additional, and Mayet, Jamil, additional

Published
2019
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