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2. POS0604 JAKi’S SURVIVAL RATE AND PREDICTORS OF DISCONTINUATION IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS

Author

Larosa, M., primary, Becciolini, A., additional, Parisi, S., additional, Donato, E. DI, additional, Camellino, D., additional, Adorni, G., additional, Lucchini, G., additional, Santilli, D., additional, Fusaro, E., additional, Ditto, M. C., additional, Lo Gullo, A., additional, Paroli, M., additional, Caccavale, R., additional, Volpe, A., additional, Marchetta, A., additional, Raffeiner, B., additional, Celletti, E., additional, Penta, M. DI, additional, Sabatini, E., additional, Cipollone, F., additional, Reta, M., additional, Addimanda, O., additional, Magnani, M., additional, Visalli, E., additional, Foti, R., additional, Amato, G., additional, De Lucia, F., additional, Farina, A., additional, Girelli, F., additional, Bernardi, S., additional, Colina, M., additional, Andracco, R., additional, Mansueto, N., additional, Ferrero, G., additional, Del Medico, P., additional, Molica Colella, A., additional, Franchina, V., additional, Molica Colella, F., additional, Lumetti, F., additional, Sandri, G., additional, Salvarani, C., additional, Giuggioli, D., additional, Priora, M., additional, Serale, F., additional, Ianniello, A., additional, Nucera, V., additional, Ometto, F., additional, Giampietro, C., additional, Bravi, E., additional, Platè, I., additional, Arrigoni, E., additional, Mascella, F., additional, Focherini, M. C., additional, Bezzi, A., additional, Scolieri, P., additional, Bruzzese, V., additional, Ravagnani, V., additional, Rovera, G., additional, Fiorenza, A., additional, Vitetta, R., additional, and Ariani, A., additional

Published
2024
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3. AB0595 DIFFERENCES BETWEEN SELECTIVE AND UNSELECTIVE JAKi: RESULTS FROM A MULTICENTRIC, REAL LIFE STUDY CARRIED OUT ON PATIENTS WITH RA

Author

Larosa, M., primary, Camellino, D., additional, Becciolini, A., additional, Donato, E. DI, additional, Adorni, G., additional, Lucchini, G., additional, Santilli, D., additional, Arrigoni, E., additional, Bravi, E., additional, Platè, I., additional, Bezzi, A., additional, Focherini, M. C., additional, Mascella, F., additional, Bruzzese, V., additional, Scolieri, P., additional, Parisi, S., additional, Ditto, M. C., additional, Fusaro, E., additional, Ravagnani, V., additional, Rovera, G., additional, Fiorenza, A., additional, Vitetta, R., additional, Marchetta, A., additional, Volpe, A., additional, Raffeiner, B., additional, Celletti, E., additional, Penta, M. DI, additional, Sabatini, E., additional, Cipollone, F., additional, Ometto, F., additional, Giampietro, C., additional, Nucera, V., additional, Ianniello, A., additional, Serale, F., additional, Priora, M., additional, Giuggioli, D., additional, Salvarani, C., additional, Sandri, G., additional, Lumetti, F., additional, Molica Colella, F., additional, Franchina, V., additional, Molica Colella, A., additional, Del Medico, P., additional, Caccavale, R., additional, Paroli, M., additional, Ferrero, G., additional, Mansueto, N., additional, Andracco, R., additional, Colina, M., additional, Bernardi, S., additional, Girelli, F., additional, Farina, A., additional, Foti, R., additional, De Lucia, F., additional, Amato, G., additional, Lo Gullo, A., additional, Magnani, M., additional, Addimanda, O., additional, Reta, M., additional, and Ariani, A., additional

Published
2024
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6. AB0452 SURVIVAL RATE OF BARICITINIB IN A LARGE COHORT OF RHEUMATOID ARTHRITIS PATIENTS: ANALYSIS OF REAL-WORLD DATA

Author

Parisi, S., primary, Becciolini, A., additional, Ditto, M. C., additional, Del Medico, P., additional, Farina, A., additional, Visalli, E., additional, Molica Colella, A., additional, Lumetti, F., additional, Caccavale, R., additional, Scolieri, P., additional, Andracco, R., additional, Girelli, F., additional, Bravi, E., additional, Colina, M., additional, Volpe, A., additional, Ianniello, A., additional, Nucera, V., additional, Franchina, V., additional, Platé, I., additional, DI Donato, E., additional, Amato, G., additional, Salvarani, C., additional, Gardelli, L., additional, Lucchini, G., additional, De Lucia, F., additional, Molica Colella, F., additional, Priora, M., additional, Santilli, D., additional, Mansueto, N., additional, Ferrero, G., additional, Rovera, G., additional, Fiorenza, A., additional, Vitetta, R., additional, Marchetta, A., additional, Ravagnani, V., additional, Paroli, M., additional, Bernardi, S., additional, Arrigoni, E., additional, Foti, R., additional, Sandri, G., additional, Bruzzese, V., additional, Ometto, F., additional, Bezzi, A., additional, Focherini, M. C., additional, Adorni, G., additional, Mascella, F., additional, Lo Gullo, A., additional, Bianchi, G., additional, Camellino, D., additional, Larosa, M., additional, Addimanda, O., additional, Reta, M., additional, Ariani, A., additional, and Fusaro, E., additional

Published
2023
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7. AB0481 UPADICITINIB EFFECTIVENESS IN RHEUMATOID ARTHRITIS: OBSERVATION FROM AN ITALIAN MULTI-CENTRIC COHORT

Author

Scolieri, P., primary, Bruzzese, V., additional, Larosa, M., additional, Farina, A., additional, Becciolini, A., additional, Lo Gullo, A., additional, Girelli, F., additional, Parisi, S., additional, Bernardi, S., additional, DI Donato, E., additional, Sandri, G., additional, Salvarani, C., additional, Bianchi, G., additional, Camellino, D., additional, Lumetti, F., additional, Del Medico, P., additional, Colina, M., additional, Bravi, E., additional, Platè, I., additional, Arrigoni, E., additional, Priora, M., additional, De Lucia, F., additional, Visalli, E., additional, Foti, R., additional, Amato, G., additional, Paroli, M., additional, Caccavale, R., additional, Andracco, R., additional, Mansueto, N., additional, Ferrero, G., additional, Molica Colella, F., additional, Franchina, V., additional, Ditto, M. C., additional, Marchetta, A., additional, Santilli, D., additional, Volpe, A., additional, Ianniello, A., additional, Nucera, V., additional, Molica Colella, A., additional, Vitetta, R., additional, Fiorenza, A., additional, Lucchini, G., additional, Adorni, G., additional, Bezzi, A., additional, Focherini, M. C., additional, Mascella, F., additional, Ravagnani, V., additional, Ometto, F., additional, Fusaro, E., additional, and Ariani, A., additional

Published
2023
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9. The impact of diet on disease activity in spondyloarthritis: A systematic literature review

Author

Ortolan, A., Felicetti, M., Lorenzin, M., Cozzi, G., Ometto, F., Striani, G., Favaro, M., Doria, A., and Ramonda, R.

Subjects
Rheumatology, Psoriatic arthritis, Régime alimentaire, Spondyloarthritis, Disease activity, Rhumatisme psoriasique, Activité de la maladie, Dietary supplements, Compléments alimentaire, Diet, Spondyloarthrite
Abstract

Our study aimed to systematically review the evidence about the effect of diet or dietary supplements on spondyloarthritis (SpA) disease activity.a systematic literature review (SLR) was conducted in MEDLINE, EMBASE, Cochrane and SCOPUS according to the "PEO" format (Population, Exposure, Outcome). The population was SpA (axial or peripheral, axSpA/pSpA, including Psoriatic Arthritis-PsA); the intervention any kind of diet/dietary supplement; the outcome disease activity. Inclusion criteria were: adult patients, Randomized Controlled Trials (RCTs) and longitudinal studies (so that a pre-and post-intervention assessment were available), papers in English. Risk of bias (RoB) was conducted with different tools according to the design of the study.Literature search yielded 1390 publications, of which 15 were finally inlcuded: 12 interventional and 3 observational studies. Among those with the lower RoB: a) 2 RCTs, one at unclear and one at low RoB, failed to show benefit of probiotics in SpA b) Two RCTs at unclear RoB provided evidence that weight loss, but not hypocaloric diet, was associated to MDA achievement in PsA. The remaining interventional studies were at high RoB. Among the observational studies, one study on Mediterranean diet demonstrated an association between diet adherence and a ≥ 20% decrease of ASDAS in axSpA. The other two observational studies were judged of poor quality.weight loss seem to be able to impact disease activity in PsA, while probiotics do not seem useful in SpA; evidence for dietary behaviors is scarce and heterogeneous.

Published
2023
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12. AB0481 UPADICITINIB EFFECTIVENESS IN RHEUMATOID ARTHRITIS: OBSERVATION FROM AN ITALIAN MULTI-CENTRIC COHORT

Author

Scolieri, P., Bruzzese, V., Larosa, M., Farina, A., Becciolini, A., Lo Gullo, A., Girelli, F., Parisi, S., Bernardi, S., DI Donato, E., Sandri, G., Salvarani, C., Bianchi, G., Camellino, D., Lumetti, F., Del Medico, P., Colina, M., Bravi, E., Platè, I., Arrigoni, E., Priora, M., De Lucia, F., Visalli, E., Foti, R., Amato, G., Paroli, M., Caccavale, R., Andracco, R., Mansueto, N., Ferrero, G., Molica Colella, F., Franchina, V., Ditto, M.C., Marchetta, A., Santilli, D., Volpe, A., Ianniello, A., Nucera, V., Molica Colella, A., Vitetta, R., Fiorenza, A., Lucchini, G., Adorni, G., Bezzi, A., Focherini, M.C., Mascella, F., Ravagnani, V., Ometto, F., Fusaro, E., and Ariani, A.

Published
2023
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13. AB0386 DIFFERENCES BETWEEN JAKIS-NAIVE AND JAKIS-NOT NAIVE PATIENTS IN A REAL LIFE CLINICAL SETTING: DATA FROM AN PROSPECTIVE MULTICENTRIC ITALIAN STUDY.

Author

Larosa, M., Becciolini, A., Bravi, E., Camellino, D., Platé, I., Arrigoni, E., Ometto, F., DI Donato, E., Adorni, G., Lucchini, G., Santilli, D., Bezzi, A., Focherini, M.C., Mascella, F., Bruzzese, V., Scolieri, P., Parisi, S., Fusaro, E., Ditto, M.C., Ravagnani, V., Sandri, G., Salvarani, C., Priora, M., Paroli, M., Caccavale, R., Andracco, R., Mansueto, N., Colina, M., Reta, M., Addimanda, O., Lo Gullo, A., Visalli, E., Foti, R., Amato, G., De Lucia, F., Farina, A., Girelli, F., Del Medico, P., Molica Colella, A., Franchina, V., Molica Colella, F., Lumetti, F., Ianniello, A., Nucera, V., Vitetta, R., Fiorenza, A., Rovera, G., Volpe, A., Ferrero, G., Marchetta, A., Bernardi, S., Bianchi, G., and Ariani, A.

Published
2023
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14. AB0452 SURVIVAL RATE OF BARICITINIB IN A LARGE COHORT OF RHEUMATOID ARTHRITIS PATIENTS: ANALYSIS OF REAL-WORLD DATA

Author

Parisi, S., Becciolini, A., Ditto, M.C., Del Medico, P., Farina, A., Visalli, E., Molica Colella, A., Lumetti, F., Caccavale, R., Scolieri, P., Andracco, R., Girelli, F., Bravi, E., Colina, M., Volpe, A., Ianniello, A., Nucera, V., Franchina, V., Platé, I., DI Donato, E., Amato, G., Salvarani, C., Gardelli, L., Lucchini, G., De Lucia, F., Molica Colella, F., Priora, M., Santilli, D., Mansueto, N., Ferrero, G., Rovera, G., Fiorenza, A., Vitetta, R., Marchetta, A., Ravagnani, V., Paroli, M., Bernardi, S., Arrigoni, E., Foti, R., Sandri, G., Bruzzese, V., Ometto, F., Bezzi, A., Focherini, M.C., Adorni, G., Mascella, F., Lo Gullo, A., Bianchi, G., Camellino, D., Larosa, M., Addimanda, O., Reta, M., Ariani, A., and Fusaro, E.

Published
2023
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15. AB0302 DISCONTINUATION RATE AND PREDICTORS OF JAKI DISCONTINUATION IN A REAL LIFE COHORT: RESULTS FROM A MULTICENTRIC ITALIAN STUDY ON 864 PATIENTS WITH RA

Author

Larosa, M., Ariani, A., Camellino, D., Becciolini, A., Bianchi, G., Di Donato, E., Adorni, G., Santilli, D., Lucchini, G., Reta, M., Addimanda, O., Lo Gullo, A., Visalli, E., Foti, R., Amato, G., De Lucia, F., Farina, A., Girelli, F., Bernardi, S., Ferrero, G., Andracco, R., Paroli, M., Mansueto, N., Caccavale, R., Del Medico, P., Molica Colella, A., Franchina, V., Molica Colella, F., Lumetti, F., Sandri, G., Salvarani, C., Priora, M., Ianniello, A., Nucera, V., Ometto, F., Platé, I., Arrigoni, E., Bezzi, A., Focherini, M.C., Mascella, F., Bruzzese, V., Scolieri, P., Parisi, S., Ditto, M.C., Fusaro, E., Ravagnani, V., Vitetta, R., Fiorenza, A., Rovera, G., Volpe, A., Marchetta, A., Colina, M., and Bravi, E.

Published
2023
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20. Adherence in rheumatoid arthritis patients assessed with a validated Italian version of the 5-item Compliance Questionnaire for Rheumatology

Author

Ometto, F., Raffeiner, B., Danila Azzolina, Botsios, C., Astorri, D., Friso, L., Favero, M., Done, D. J., Gregori, D., and Doria, A.

Subjects
rheumatoid arthritis, Biological Products, Patients, rheumatoid arthritis, compliance, Socio-culturale, Ambientale, Reproducibility of Results, compliance, Medication Adherence, Arthritis, Rheumatoid, Economica, Rheumatology, Antirheumatic Agents, Surveys and Questionnaires, Humans, Patient Compliance
Abstract

The 5-item Compliance Questionnaire for Rheumatology (CQR5) proved reliability and validity in respect of identification of patients likely to be high adherers (HAs) to anti-rheumatic treatment, or low adherers (LAs), i.e. taking80% of their medications correctly. The objective of the study was to validate an Italian version of CQR5 (I-CQR5) in rheumatoid arthritis (RA) patients and to investigate factors associated with high adherence.RA patients, undergoing treatment with ≥1 self-administered conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) or biological DMARD (bDMARD), were enrolled. The cross-cultural adaptation and validation of I-CQR5 followed standardised guidelines. I-CQR5 was completed by patients on one occasion. Data were subjected to factor analysis and Partial Credit model Parametrisation (PCM) to assess construct validity of I-CQR5. Analysis of factors associated with high adherence included demographic, social, clinical and treatment information. Factors achieving a p0.10 in univariate analysis were included in multivariable analysis.Among 604 RA patients, 274 patients were included in the validation and 328 in the analysis of factors associated with adherence. Factor analysis and PCM confirmed the construct validity and consistency of I-CQR5. HAs were found to be 109 (35.2%) of the patients. bDMARD treatment and employment were found to be independently associated with high adherence: OR 2.88 (1.36-6.1), p=0.006 and OR 2.36 (1.21-4.62), p=0.012, respectively.Only one-third of RA patients were HAs according to I-CQR5. bDMARDs and employment status increased by almost 3-fold the likelihood of being highly adherent to the anti-rheumatic treatment.

Published
2018

21. Erratum to: Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: A 24-month observational study [Arthritis Research & Therapy, (2016), 18: 120] DOI: 10.1186/s13075-016-1019-9

Author

Ometto, F., Raffeiner, B., Bernardi, L., Botsios, C., Veronese, N., Punzi, L., Doria, A., Ometto, F., Raffeiner, B., Bernardi, L., Botsios, C., Veronese, N., Punzi, L., and Doria, A.

Subjects
rheumatoid arthritis
Abstract

Unfortunately, after publication of this article [1], it was noticed that the author name Constantino Botsios was incorrectly spelled during the production process. The corrected name can be seen in the author list above and the original article has also been updated to reflect this. © 2016 Ometto et al.

Published
2016

27. Inclusion of Saccharina latissima in conventional anaerobic digestion systems

Author

Ometto, F., Berg, A., Björn, Annika, Safaric, Luka, Svensson, Bo H., Karlsson, A., Ejlertsson, Jörgen, Ometto, F., Berg, A., Björn, Annika, Safaric, Luka, Svensson, Bo H., Karlsson, A., and Ejlertsson, Jörgen

Abstract

Loading macroalgae into existing anaerobic digestion (AD) plants allows us to overcome challenges such as low digestion efficiencies, trace elements limitation, excessive salinity levels and accumulation of volatile fatty acids (VFAs), observed while digesting algae as a single substrate. In this work, the co-digestion of the brown macroalgae Saccharina latissima with mixed municipal wastewater sludge (WWS) was investigated in mesophilic and thermophilic conditions. The hydraulic retention time (HRT) and the organic loading rate (OLR) were fixed at 19 days and 2.1 g l-1 d-1of volatile solids (VS), respectively. Initially, WWS was digested alone. Subsequently, a percentage of the total OLR (20%, 50% and finally 80%) was replaced by S. latissima biomass. Optimal digestion conditions were observed at medium-low algae loading (=50% of total OLR) with an average methane yield close to [Formula: see text] and [Formula: see text] in mesophilic and thermophilic conditions, respectively. The conductivity values increased with the algae loading without inhibiting the digestion process. The viscosities of the reactor sludges revealed decreasing values with reduced WWS loading at both temperatures, enhancing mixing properties.

Published
2018
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50. An umbrella review of systematic reviews with meta-analyses evaluating positive and negative outcomes of Hydroxychloroquine and chloroquine therapy

Author

Lee Smith, Yvonne Barnett, Jacopo Demurtas, Peter Konstantin Kurotschka, Shahina Pardhan, Francesca Ometto, Petre Cristian Ilie, Nicola Veronese, Pinar Soysal, Erik Lagolio, Roberto Tonelli, Mario Barbagallo, Stefano Celotto, Celotto S., Veronese N., Barbagallo M., Ometto F., Smith L., Pardhan S., Barnett Y., Ilie P.C., Soysal P., Lagolio E., Kurotschka P.K., Tonelli R., Demurtas J., and SOYSAL, PINAR

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, hydroxychloroquine, 030106 microbiology, Disease, Review, lcsh:Infectious and parasitic diseases, law.invention, chloroquine, 03 medical and health sciences, 0302 clinical medicine, systematic review, Randomized controlled trial, law, Chloroquine, Internal medicine, Diabetes mellitus, COVID-19, Hydroxychloroquine, umbrella review, Humans, SARS-CoV-2, medicine, lcsh:RC109-216, 030212 general & internal medicine, business.industry, General Medicine, medicine.disease, Confidence interval, COVID-19 Drug Treatment, Infectious Diseases, Systematic review, Observational study, business, medicine.drug, Human
Abstract

Background & aims: Hydroxychloroquine (HCQ) and chloroquine (CQ) are anti-malarial drugs frequently used in the rheumatologic field. They were recently identified as potential therapeutic options for Coronavirus Disease (COVID-19). The present study aims to map and grade the diverse health outcomes associated with HCQ/CQ using an umbrella review approach. Methods: Umbrella review of systematic reviews of observational and intervention studies. For observational studies, random-effects summary effect size, 95% confidence interval, and 95% prediction interval were estimated. We also assessed heterogeneity, evidence for small-study effect, and evidence for excess significance bias. The quality of evidence was then graded using validated criteria from highly convincing to weak. The evidence from randomized controlled trials (RCTs) was graded using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) tool. Results: From 313 articles returned in the literature search, six meta-analyses were included (n = 25 outcomes). Among meta-analyses (MAs) of observational studies, HCQ/CQ are weakly associated with a reduced risk for cardiovascular events and diabetes when used for autoimmune diseases and with spontaneous abortion; they are also associated with a higher risk of death in COVID-19 patients. Among MAs of RCTs, HCQ/CQ are associated with an improvement of articular manifestations of rheumatic diseases. Conclusions: There is high evidence of the efficacy of HCQ/CQ in the rheumatologic field. The lack of evidence for efficacy and the risk of death associated with the use of HCQ/CQ for COVID-19 indicate the inappropriateness of their inclusion in recent COVID-19 therapy guidelines and the urgent need for RCTs to determine eventual appropriateness as a COVID-19 therapy. Keywords: COVID-19; Chloroquine; Hydroxychloroquine; umbrella review. https://www.sciencedirect.com/science/article/pii/S1201971220325418?via%3Dihub

Published
2021

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