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Supplemental material, sj-docx-1-car-10.1177_19476035211069251 for The Association of Blood Biomarkers and Body Mass Index in Knee Osteoarthritis: A Cross-Sectional Study by Paul Schadler, Birgit Lohberger, Bettina Thauerer, Martin Faschingbauer, Werner Kullich, Martin Helmut Stradner, Andreas Leithner, Valentin Ritschl, Maisa Omara and Bibiane Steinecker-Frohnwieser in CARTILAGE

OBJECTIVE: To be fit-for-purpose, oral health-related quality of life instruments must possess a range of psychometric properties which had not been fully examined in the 16-item Short Form Child Perceptions Questionnaire for children aged 11 to 14 years (CPQ11-14 ISF-16). We used advanced statistical approaches to determine the CPQ's measurement accuracy, precision, invariance and dimensionality and analyzed whether age range could be extended from 8 to 15 years. METHODS: Fit to the Rasch model was examined in 6648 8-to-15-year-olds from Australia, New Zealand, Brunei, Cambodia, Hong Kong, Malaysia, Thailand, Germany, United Kingdom, Brazil and Mexico. RESULTS: In all but two items, the initial five answer options were reduced to three or four, to increase precision of the children's selection. Items 10 (Shy/embarrassed) and 11 (Concerned what others think) showed an 'extra' dependency between item scores beyond the relationship related to the underlying latent construct represented by the instrument, and so were deleted. Without these two items, the CPQ was unidimensional. The three oral symptoms items (4 Food stuck in teeth, 3 Bad breath and 1 Pain) were required for a sufficient person-item coverage. In three out of 14 items (21 %), Europe and South America showed regional differences in the patterns of how the answer options were selected. No differential item functioning was detected for age. CONCLUSION: Except for a few modifications, the present analysis supports the combination of items, the cross-cultural validity of the CPQ with 14 items and the extension of the age range from 8 to 15 years. CLINICAL SIGNIFICANCE: The valid, reliable, shortened and age-extended version of the CPQ resulting from this study should be used in routine care and clinical research. Less items and a wider age range increase its usability. Symptoms items are needed to precisely differentiate between children with higher and lower quality of life

Cancer is one of the leading causes of death worldwide. Oral cancer, the most common cancer of the head and neck region, ranks eighth among the most prevalent cancers in the world. In Egypt in 1991 the adjusted death rates for malignant neoplasm of the lip, oral cavity and pharynx were 0.3 per 100,000 person-years for males and 0.2 per 100,000 person-years for females. The etiology of oral cancer is multifactorial, the most important risk factors being tobacco, excess consumption of alcohol and betel quid usage, factors which act separately and synergistically. Much oral and other cancer therefore is potentially preventable by lifestyle change. This study aimed to describe predisposing factors & oral findings of oral cancer patients. A total sample of 89 patients, fulfilling the inclusion criteria were enrolled in the study at university hospitals in Cairo, Alexandria and El Menia during the study period (2011-2012). The result of the study revealed that the majority of sample was males and more than half of the sample (52.5%) belonged to 41-60years age group, also about two thirds of them were illiterate or read and write (62.5%). Regarding cancer location, about half of the sample (40%) had naso-pharyngeal cancer. Most of the sample smoked tobacco products (71.4%) and Cigarettes were the most common type followed by shisha. The majority of the sample had a history of dental problem (76.3%), about half (52.6%) never used tooth brush and only 5.3% visited dentist every 6-12 month.

Background. Oral health is related to major chronic diseases and contributes to general health.Oral healtherelated quality of life (OHRQoL) is, therefore, an essential part of well-being. Measurement of OHRQoL over the lifetime requires accurate and comparable outcome measures that are suitable for different age groups. The most frequently used instrument for children aged 11 through 14 years is the Child Perceptions Questionnaire (CPQ-11-14). The authors aimed to examine the psychometric properties of the CPQ-11-14 using modern statistical approaches. Methods. The authors carried out a psychometric analysis of 2 population-representative data sets from Germany (N ¼ 2,658) and a randomly selected smaller sample (n ¼ 300) on the basis of theRasch model. Results. The authors detected a right-skewed distribution of the CPQ-11-14 total scores. Theinstrument items did not match the level of OHRQoL of the study participants. Moreover, a large number of questionnaire items (range, 51.4%-94.3%) had so-called disordered thresholds, meaning that the answer categories did not work as intended. Unidimensionality was achieved via splitting the CPQ-11-14 into 2 subscales, namely socioemotional and oral symptoms and functioning. Conclusions. Despite its classic validation, the CPQ-11-14 needs adaptions for meaningful clinical use. More items on the better end of the scale are needed to better differentiate between children with higher and lower OHRQoL. Practical Implications. The Rasch model addresses psychometric properties of questionnaires on an item-based level, which were not detected via classic approaches. The results reported by the authors are needed to generate a well-calibrated outcome measure for accurate clinical and public health assessment of OHRQoL. Refereed/Peer-reviewed

Overview about the content of the intervention program and the activity-inducing material used. (DOCX 14 kb)

Baseline characteristics of start-to-end participants and surrogates. (DOCX 14 kb)

Interview questions for the needs assessment. (DOCX 14 kb)

Interview questions for the pilot and the rollout phases. (DOCX 16 kb)