1. Comparative Analysis of Hand-Crafted and Machine-Driven Histopathological Features for Prostate Cancer Classification and Segmentation
- Author
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Baqain, Feda Bolus Al and Al-Kadi, Omar Sultan
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods - Abstract
Histopathological image analysis is a reliable method for prostate cancer identification. In this paper, we present a comparative analysis of two approaches for segmenting glandular structures in prostate images to automate Gleason grading. The first approach utilizes a hand-crafted learning technique, combining Gray Level Co-Occurrence Matrix (GLCM) and Local Binary Pattern (LBP) texture descriptors to highlight spatial dependencies and minimize information loss at the pixel level. For machine driven feature extraction, we employ a U-Net convolutional neural network to perform semantic segmentation of prostate gland stroma tissue. Support vector machine-based learning of hand-crafted features achieves impressive classification accuracies of 99.0% and 95.1% for GLCM and LBP, respectively, while the U-Net-based machine-driven features attain 94% accuracy. Furthermore, a comparative analysis demonstrates superior segmentation quality for histopathological grades 1, 2, 3, and 4 using the U-Net approach, as assessed by Jaccard and Dice metrics. This work underscores the utility of machine-driven features in clinical applications that rely on automated pixel-level segmentation in prostate tissue images., Comment: 13 pages, 14 figures, 2 tables
- Published
- 2025
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