7 results on '"Olsson, P. (Per)"'
Search Results
2. Dopamine D2 Occupancy as a Biomarker for Antipsychotics: Quantifying the Relationship with Efficacy and Extrapyramidal Symptoms
- Author
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de Greef, Rik, Maloney, Alan, Olsson-Gisleskog, Per, Schoemaker, Joep, and Panagides, John
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- 2011
- Full Text
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3. Population Pharmacokinetics Meta-Analysis of Recombinant Human Erythropoietin in Healthy Subjects
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Olsson-Gisleskog, Per, Jacqmin, Philippe, and Perez-Ruixo, Juan Jose
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- 2007
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4. Transformative spaces in the making: key lessons from nine cases in the Global South
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Pereira, L. (Laura), Frantzeskaki, N. (Niki), Hebinck, A. (Aniek), Charli-Joseph, L. (Lakshmi), Drimie, S. (Scott), Dyer, M. (Michelle), Eakin, H. (Hallie), Galafassi, D. (Diego), Karpouzoglou, T. (Timothy), Marshall, F. (Fiona), Moore, M.-L. (Michele-Lee), Olsson, P. (Per), Siqueiros-García, J.M. (J. Mario), van Zwanenberg, P. (Patrick), Vervoort, J.M. (Joost M.), Pereira, L. (Laura), Frantzeskaki, N. (Niki), Hebinck, A. (Aniek), Charli-Joseph, L. (Lakshmi), Drimie, S. (Scott), Dyer, M. (Michelle), Eakin, H. (Hallie), Galafassi, D. (Diego), Karpouzoglou, T. (Timothy), Marshall, F. (Fiona), Moore, M.-L. (Michele-Lee), Olsson, P. (Per), Siqueiros-García, J.M. (J. Mario), van Zwanenberg, P. (Patrick), and Vervoort, J.M. (Joost M.)
- Abstract
Creating a just and sustainable planet will require not only small changes, but also systemic transformations in how humans relate to the planet and to each other, i.e., social–ecological transformations. We suggest there is a need for collaborative environments where experimentation with new configurations of social–ecological systems can occur, and we refer to these as transformative spaces. In this paper, we seek a better understanding of how to design and enable the creation of transformative spaces in a development context. We analyse nine case studies from a previous special issue on Designing Transformative Spaces that aimed to collect examples of cutting-edge action-oriented research on transformations from the Global South. The analysis showed five design phases as being essential: Problem Definition Phase; Operationalisation Phase; Tactical Phase; Outcome Phase; and Reflection Phase. From this synthesis, we distilled five key messages that should be considered when designing research, including: (a) there are ethical dilemmas associated with creating a transformative space in a system; (b) it is important to assess the readiness of the system for change before engaging in it; (c) there is a need to balance between ‘safe’ and ‘safe-enough’ spaces for transformation; (d) convening a transformative space requires an assemblage of diverse methodological frameworks and tools; and (e) transformative spaces can act as a starting point for institutionalising transformative change. Many researchers are now engaging in transdisciplinary transformations research, and are finding themselves at the knowledge–action interface contributing to transformative space-making. We hope that by analysing experiences from across different geographies we can contribute towards better understanding of how to navigate the processes needed for the urgent global transformations that are being called for to create a more equitable and sustainable planet Earth.
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- 2019
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5. Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjogren's syndrome
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Olsson, P. (Per), Bodewes, I.L.A. (Iris), Nilsson, A.M., Turesson, C., Jacobsson, L.T.H., Theander, E., Versnel, M.A. (Marjan), Mandl, T., Olsson, P. (Per), Bodewes, I.L.A. (Iris), Nilsson, A.M., Turesson, C., Jacobsson, L.T.H., Theander, E., Versnel, M.A. (Marjan), and Mandl, T.
- Abstract
Several studies have shown a negative association between smoking and primary Sjögren’s syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patients filled out the EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) form and a structured questionnaire regarding smoking habits. EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) scores were calculated and blood samples were analysed for type I interferon signature using RT-PCR. Of 90 patients (93% women, median age 66.5 years), 72% were type I IFN signature positive and 6, 42 and 53% were current, former and never smokers, respectively. No significant differences by smoking status were found regarding ESSDAI total score, activity in the ESSDAI domains or type I IFN signature. Patients with a higher cumulative cigarette consumption (≥ median) had higher scores in ESSPRI total [5.0 (3.0–6.3) vs 8.0 (6.0–8.3); p < 0.01] and ESSPRI sicca and pain domains. Comparing type I IFN signature negative and positive patients, the latter had significantly lower activity
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- 2019
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6. Ten essentials for action-oriented and second order energy transitions, transformations and climate change research
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Fazey, I. (Ioan), Schäpke, N. (Niko), Caniglia, G. (Guido), Patterson, J. (James), Hultman, J. (Johan), Van Mierlo, B. (Barbara), Säwe, F. (Filippa), Wiek, A. (Arnim), Wittmayer, J.M. (Julia), Aldunce, P. (Paulina), Al Waer, H. (Husam), Battacharya, N. (Nandini), Bradbury, H. (Hilary), Carmen, E. (Esther), Colvin, J. (John), Cvitanovic, C. (Christopher), D'Souza, M. (Marcella), Gopel, M. (Maja), Goldstein, B. (Bruce), Hämäläinen, T. (Timo), Harper, G. (Gavin), Henfry, T. (Tom), Hodgson, A. (Anthony), Howden, M.S. (Mark S.), Kerr, A. (Andy), Klaes, M. (Matthias), Lyon, C. (Christopher), Midgley, G. (Gerald), Moser, S. (Susanne), Mukherjee, N. (Nandan), Müller, K. (Karl), O'Brien, K. (Karen), O'Connell, D.A. (Deborah A.), Olsson, P. (Per), Page, G. (Glenn), Reed, M.S. (Mark S.), Searle, B. (Beverley), Silvestri, G. (Giorgia), Spaiser, V. (Viktoria), Strasser, T. (Tim), Tschakert, P. (Petra), Uribe-Calvo, N. (Natalia), Waddell, S. (Steve), Rao-Williams, J. (Jennifer), Wise, R. (Russell), Wolstenholme, R. (Ruth), Woods, M. (Mel), Wyborn, C. (Carina), Fazey, I. (Ioan), Schäpke, N. (Niko), Caniglia, G. (Guido), Patterson, J. (James), Hultman, J. (Johan), Van Mierlo, B. (Barbara), Säwe, F. (Filippa), Wiek, A. (Arnim), Wittmayer, J.M. (Julia), Aldunce, P. (Paulina), Al Waer, H. (Husam), Battacharya, N. (Nandini), Bradbury, H. (Hilary), Carmen, E. (Esther), Colvin, J. (John), Cvitanovic, C. (Christopher), D'Souza, M. (Marcella), Gopel, M. (Maja), Goldstein, B. (Bruce), Hämäläinen, T. (Timo), Harper, G. (Gavin), Henfry, T. (Tom), Hodgson, A. (Anthony), Howden, M.S. (Mark S.), Kerr, A. (Andy), Klaes, M. (Matthias), Lyon, C. (Christopher), Midgley, G. (Gerald), Moser, S. (Susanne), Mukherjee, N. (Nandan), Müller, K. (Karl), O'Brien, K. (Karen), O'Connell, D.A. (Deborah A.), Olsson, P. (Per), Page, G. (Glenn), Reed, M.S. (Mark S.), Searle, B. (Beverley), Silvestri, G. (Giorgia), Spaiser, V. (Viktoria), Strasser, T. (Tim), Tschakert, P. (Petra), Uribe-Calvo, N. (Natalia), Waddell, S. (Steve), Rao-Williams, J. (Jennifer), Wise, R. (Russell), Wolstenholme, R. (Ruth), Woods, M. (Mel), and Wyborn, C. (Carina)
- Abstract
The most critical question for climate research is no longer about the problem, but about how to facilitate the transformative changes necessary to avoid catastrophic climate-induced change. Addressing this question, however, will require massive upscaling of research that can rapidly enhance learning about transformations. Ten essentials for guiding action-oriented transformation and energy research are therefore presented, framed in relation to second-order science. They include: (1) Focus on transformations to low-carbon, resilient living; (2) Focus on solution processes; (3) Focus on ‘how to’ practical knowledge; (4) Approach research as occurring from within the system being intervened; (5) Work with normative aspects; (6) Seek to transcend current thinking; (7) Take a multi-faceted approach to understand and shape change; (8) Acknowledge the value of alternative roles of researchers; (9) Encourage second-order experimentation; and (10) Be reflexive. Joint application of the essentials would create highly adaptive, reflexive, collaborative and impact-oriented research able to enhance capacity to respond to the climate challenge. At present, however, the practice of such approaches is limited and constrained by dominance of other approaches. For wider transformations to low carbon living and energy systems to occur, transformations will therefore also be needed in the way in which knowledge is produced and used.
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- 2018
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7. Extrapolation and Justification of Nplate Dosing to Improve Overall Survival in Acute Radiation Syndrome
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Doshi, Sameer, Jones, Zachary, Pritchard-Bell, Ari, Park, Joseph, and Olsson Gisleskog, Per
- Abstract
Background: Acute Radiation Syndrome (ARS) is an acute illness caused by exposure to a high dose of penetrating radiation over a short period of time. Hematopoietic subsyndrome of ARS (HS-ARS) is characterized by dose dependent bone marrow depression leading to lymphopenia, neutropenia, thrombocytopenia, and anemia. Death due to HS-ARS from infection or excessive bleeding usually occurs within 2 to 3 weeks. Duration of thrombocytopenia is a predictor of overall survival (OS) in irradiated animal models, suggesting that a treatment for thrombocytopenia may increase survival in humans with HS-ARS. Romiplostim, a thrombopoietin receptor agonist, treatment resulted in prevention of severe thrombocytopenia and increased OS in irradiated animals. As human clinical trials for HS-ARS are not feasible or ethical, a romiplostim pharmacokinetic/pharmacodynamic (PKPD)-OS model for irradiated humans was developed. The model, informed by PKPD data in healthy/irradiated rhesus monkeys (RM) and healthy volunteers (HV), was subsequently used to predict the survival benefit of romiplostim relative to placebo in humans with HS-ARS.
- Published
- 2020
- Full Text
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