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1,058 results on '"Olsson, Ann"'

4. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

Olsson, Ann, Bouaoun, Liacine, Schuz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jockel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernandez-Tardon, Guillermo, Zaridze, David, Field, John K., Lissowska, Jolanta, Swiatkowska, Beata, McLaughlin, John R., Demers, Paul A., Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Bruning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Subjects
Smoking -- Research -- Risk factors, Lung cancer -- Research -- Risk factors, Polycyclic aromatic hydrocarbons -- Research, Silica -- Research, Cigarettes -- Research, Environmental issues, Health
Abstract

Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents. Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking. Methods: In the international 14-center SYNERGY project, occupational exposures were assigned to 16,901 lung cancer cases and 20,965 control subjects using a quantitative job-exposure matrix (SYN-JEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed for ever vs. never exposure using logistic regression models stratified by sex and adjusted for study center, age, and smoking habits. Joint effects among pairs of agents were assessed on multiplicative and additive scales, the latter by calculating the relative excess risk due to interaction (RERI). Results: All pairwise joint effects of lung carcinogens in men were associated with an increased risk of lung cancer. However, asbestos/metals and metals/PAH resulted in less than additive effects; while the chromium-VI/silica pair showed marginally synergistic effect in relation to adenocarcinoma (RERI: 0.24; CI: 0.02, 0.46; p = 0.05). In women, several pairwise joint effects were observed for small cell lung cancer including exposure to PAH/silica (OR = 5.12; CI: 1.77, 8.48), and to asbestos/silica (OR = 4.32; CI: 1.35, 7.29), where exposure to PAH/silica resulted in a synergistic effect (RERI: 3.45; CI: 0.10, 6.8). Discussion: Small or no deviation from additive or multiplicative effects was observed, but co-exposure to the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380, Introduction Occupational carcinogens represent a significant threat on worker's health, and exposed workers may be (simultaneously) exposed to more than one carcinogen. The European CAREX project estimated that 23% of [...]

Published
2024
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5. Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden

Author

Corbin, Sara, Togawa, Kayo, Schüz, Joachim, Le Cornet, Charlotte, Fervers, Beatrice, Feychting, Maria, Wiebert, Pernilla, Hansen, Johnni, Dalton, Susanne Oksbjerg, Kjærheim, Kristina, Nordby, Karl-Christian, Østrem, Ragnhild Strand, Skakkebæk, Niels E., Uuksulainen, Sanni, Pukkala, Eero, and Olsson, Ann

Published
2022
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7. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Brenner, Darren R, Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Diao, Nancy, Hong, Yun-Chul, Landi, Maria T, Morgenstern, Hal, Schwartz, Ann G, Rennert, Gad, Saliba, Walid, McLaughlin, John R, Harris, Curtis C, Orlow, Irene, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J, Andrew, Angeline S, Consonni, Dario, Olsson, Ann, Hung, Rayjean J, and Straif, Kurt

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Sciences, Public Health, Oncology and Carcinogenesis, Cancer, Alcoholism, Alcohol Use and Health, Lung Cancer, Lung, Prevention, Substance Misuse, 2.2 Factors relating to the physical environment, Aetiology, Stroke, Good Health and Well Being, Adenocarcinoma, Aged, Alcohol Drinking, Alcoholic Beverages, Carcinoma, Squamous Cell, Case-Control Studies, Cohort Studies, Female, Humans, Lung Neoplasms, Male, Middle Aged, Odds Ratio, Risk Factors, Surveys and Questionnaires, Alcohol, Lung cancer, Pooled analysis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThere is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.MethodsTwenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.ResultsWe observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).ConclusionsWhether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Published
2019

9. Application of two job indices for general occupational demands in a pooled analysis of case–control studies on lung cancer

Author

Hovanec, Jan, Siemiatycki, Jack, Conway, David I, Olsson, Ann, Guenel, Pascal, Luce, Danièle, Jöckel, Karl-Heinz, Pohlabeln, Hermann, Ahrens, Wolfgang, Karrasch, Stefan, Wichmann, Heinz-Erich, Gustavsson, Per, Consonni, Dario, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Fortes, Cristina, Parent, Marie-Élise, McLaughlin, John R, Demers, Paul, Landi, Maria Teresa, Caporaso, Neil, Fernández-Tardón, Guillermo, Zaridze, David, Świątkowska, Beata, Pándics, Tamas, Lissowska, Jolanta, Fabianova, Eleonora, Field, John K, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Kromhout, Hans, Vermeulen, Roel, Boffetta, Paolo, Straif, Kurt, Schüz, Joachim, Casjens, Swaantje, Pesch, Beate, Brüning, Thomas, and Behrens, Thomas

Published
2021

10. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Author

Schüz, Joachim, primary, Kovalevskiy, Evgeny V., additional, Olsson, Ann, additional, Moissonnier, Monika, additional, Ostroumova, Evgenia, additional, Ferro, Gilles, additional, Feletto, Eleonora, additional, Schonfeld, Sara J., additional, Byrnes, Graham, additional, Tskhomariia, Iraklii M., additional, Straif, Kurt, additional, Morozova, Tatiana V., additional, Kromhout, Hans, additional, and Bukhtiyarov, Igor V., additional

Published
2024
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12. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Fehringer, Gordon, Brenner, Darren R, Zhang, Zuo‐Feng, Lee, Yuan‐Chin Amy, Matsuo, Keitaro, Ito, Hidemi, Lan, Qing, Vineis, Paolo, Johansson, Mattias, Overvad, Kim, Riboli, Elio, Trichopoulou, Antonia, Sacerdote, Carlotta, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David C, Hong, Yun‐Chul, Landi, Maria Teresa, Morgenstern, Hal, Schwartz, Ann G, Wenzlaff, Angela S, Rennert, Gad, McLaughlin, John R, Harris, Curtis C, Olivo‐Marston, Susan, Orlow, Irene, Park, Bernard J, Zauderer, Marjorie, Dios, Juan M Barros, Raviña, Alberto Ruano, Siemiatycki, Jack, Koushik, Anita, Lazarus, Philip, Fernández‐Somoano, Ana, Tardon, Adonina, Le Marchand, Loic, Brenner, Hermann, Saum, Kai‐Uwe, Duell, Eric J, Andrew, Angeline S, Szeszenia‐Dabrowska, Neonila, Lissowska, Jolanta, Zaridze, David, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Foretova, Lenka, Janout, Vladimir, Bencko, Vladimir, Holcatova, Ivana, Pesatori, Angela Cecilia, Consonni, Dario, Olsson, Ann, Straif, Kurt, and Hung, Rayjean J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Cancer, Substance Misuse, Tobacco, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Prevention, Lung Cancer, Cardiovascular, Stroke, Respiratory, Good Health and Well Being, Aged, Alcohol Drinking, Alcoholic Beverages, Asia, Case-Control Studies, Cohort Studies, Europe, Female, Humans, Lung Neoplasms, Male, Middle Aged, North America, Risk Factors, Smoking, alcohol, lung cancer, wine, beer, liquor, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

Published
2017

13. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Abstract

OBJECTIVES: The quantitative job-exposure matrix SYN-JEM consists of various dimensions: job-specific estimates, region-specific estimates, and prior expert ratings of jobs by the semi-quantitative DOM-JEM. We analyzed the effect of different JEM dimensions on the exposure-response relationships between occupational silica exposure and lung cancer risk to investigate how these variations influence estimates of exposure by a quantitative JEM and associated health endpoints.METHODS: Using SYN-JEM, and alternative SYN-JEM specifications with varying dimensions included, cumulative silica exposure estimates were assigned to 16 901 lung cancer cases and 20 965 controls pooled from 14 international community-based case-control studies. Exposure-response relationships based on SYN-JEM and alternative SYN-JEM specifications were analyzed using regression analyses (by quartiles and log-transformed continuous silica exposure) and generalized additive models (GAM), adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk.RESULTS: SYN-JEM and alternative specifications generated overall elevated and similar lung cancer odds ratios ranging from 1.13 (1st quartile) to 1.50 (4th quartile). In the categorical and log-linear analyses SYN-JEM with all dimensions included yielded the best model fit, and exclusion of job-specific estimates from SYN-JEM yielded the poorest model fit. Additionally, GAM showed the poorest model fit when excluding job-specific estimates.CONCLUSION: The established exposure-response relationship between occupational silica exposure and lung cancer was marginally influenced by varying the dimensions of SYN-JEM. Optimized modelling of exposure-response relationships will be obtained when incorporating all relevant dimensions, namely prior rating, job, time, and region. Quantitative job-specific estimates appeared to be the most prominent dimens

Published
2024

14. Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

Author

Schüz, Joachim, Kovalevskiy, Evgeny, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J, Byrnes, Graham, Tskhomariia, Iraklii, Straif, Kurt, Morozova, Tatiana, Kromhout, Hans, Bukhtiyarov, Igor, Schüz, Joachim, Kovalevskiy, Evgeny, Olsson, Ann, Moissonnier, Monika, Ostroumova, Evgenia, Ferro, Gilles, Feletto, Eleonora, Schonfeld, Sara J, Byrnes, Graham, Tskhomariia, Iraklii, Straif, Kurt, Morozova, Tatiana, Kromhout, Hans, and Bukhtiyarov, Igor

Abstract

BACKGROUND: We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation.METHODS: This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models.RESULTS: A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR = 7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR = 4.56, 95% CI = 0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer.CONCLUSION: In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted.

Published
2024

15. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Abstract

Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer. Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03-1.22) to 1.32 (95% confidence interval, 1.18-1.48) (Ptrend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (Ptrend < 0.001) and a decreasing trend with longer time since last exposure (Ptrend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. Conclusions: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Published
2024

16. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

17. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, Peters, Susan, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Published
2024

18. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Published
2024

19. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

20. Political representatives' experiences of child participation in decision‐making processes: A qualitative interview study.

Author

Juliussen, Annika Karlsson, Garmy, Pernilla, and Olsson, Ann‐Margreth

Subjects
QUALITATIVE research, CONTENT analysis, DECISION making, DESCRIPTIVE statistics, ATTITUDE (Psychology), HUMAN rights, PRACTICAL politics, DATA analysis software, HEALTH promotion, PATIENT participation, LOCAL government
Abstract

The aim was to explore political representatives' experiences of child participation in decision‐making processes in municipalities. Interviews were conducted with Swedish politicians (n = 7) representing four municipalities. Qualitative content analysis was used to analyse the data. Politicians had experiences in child participation and methods for involving children and young people in the practice. However, methods were not formalized within the organizations, underlining that work lies ahead to ensure children's participation in decisions that concern them. Further research should focus on methods for including child participation at the municipal level and on following the implementation of the UNCRC. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Ohlander, Johan, primary, Kromhout, Hans, additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Kendzia, Benjamin, additional, Savary, Barbara, additional, Cavallo, Domenico, additional, Cattaneo, Andrea, additional, Migliori, Enrica, additional, Richiardi, Lorenzo, additional, Plato, Nils, additional, Wichmann, Heinz-Erich, additional, Karrasch, Stefan, additional, Consonni, Dario, additional, Landi, Maria Teresa, additional, Caporaso, Neil E, additional, Siemiatycki, Jack, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Ahrens, Wolfgang, additional, Pohlabeln, Hermann, additional, Fernández-Tardón, Guillermo, additional, Zaridze, David, additional, Jolanta Lissowska, Jolanta Lissowska, additional, Beata Swiatkowska, Beata Swiatkowska, additional, John K Field, John K Field, additional, McLaughlin, John R, additional, Demers, Paul A, additional, Pandics, Tamas, additional, Forastiere, Francesco, additional, Fabianova, Eleonora, additional, Schejbalova, Miriam, additional, Foretova, Lenka, additional, Janout, Vladimir, additional, Mates, Dana, additional, Barul, Christine, additional, Brüning, Thomas, additional, Behrens, Thomas, additional, Straif, Kurt, additional, Schüz, Joachim, additional, Olsson, Ann, additional, and Peters, Susan, additional

Published
2024
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23. Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case–control study

Author

Paul, Adèle, primary, Danjou, Aurélie M. N., additional, Deygas, Floriane, additional, Guth, Margot, additional, Coste, Astrid, additional, Lefevre, Marie, additional, Dananché, Brigitte, additional, Kromhout, Hans, additional, Spinosi, Johan, additional, Béranger, Rémi, additional, Pérol, Olivia, additional, Boyle, Helen, additional, Hersant, Christel, additional, Loup-Cabaniols, Vanessa, additional, Veau, Ségolène, additional, Bujan, Louis, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Fervers, Béatrice, additional, and Charbotel, Barbara, additional

Published
2024
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24. Prevalent occupational exposures and risk of lung cancer among women: Results from the application of the Canadian Job‐Exposure Matrix (CANJEM) to a combined set of ten case–control studies

Author

Xu, Mengting, primary, Ho, Vikki, additional, Lavoué, Jérôme, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Richardson, Lesley, additional, Parent, Marie‐Elise, additional, McLaughlin, John R., additional, Demers, Paul A., additional, Guénel, Pascal, additional, Radoi, Loredana, additional, Wichmann, Heinz‐Erich, additional, Ahrens, Wolfgang, additional, Jöckel, Karl‐Heinz, additional, Consonni, Dario, additional, Landi, Maria T., additional, Richiardi, Lorenzo, additional, Simonato, Lorenzo, additional, 't' Mannetje, Andrea, additional, Świątkowska, Beata, additional, Field, John K., additional, Pearce, Neil, additional, and Siemiatycki, Jack, additional

Published
2024
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25. Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring : findings from the Childhood Leukaemia International Consortium (CLIC)

Author

Talibov, Madar, Olsson, Ann, Bailey, Helen, Erdmann, Friederike, Metayer, Catherine, Magnani, Corrado, Petridou, Eleni, Auvinen, Anssi, Spector, Logan, Clavel, Jacqueline, Roman, Eve, Dockerty, John, Nikkilä, Atte, Lohi, Olli, Kang, Alice, Psaltopoulou, Theodora, Miligi, Lucia, Vila, Javier, Cardis, Elisabeth, and Schüz, Joachim

Published
2019

26. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Brenner, Darren R., Fehringer, Gord, Zhang, Zuo-Feng, Lee, Yuan-Chin Amy, Meyers, Travis, Matsuo, Keitaro, Ito, Hidemi, Vineis, Paolo, Stucker, Isabelle, Boffetta, Paolo, Brennan, Paul, Christiani, David. C., Diao, Nancy, Hong, Yun-Chul, Landi, Maria T., Morgenstern, Hal, Schwartz, Ann G., Rennert, Gad, Saliba, Walid, McLaughlin, John R., Harris, Curtis C., Orlow, Irene, Barros Dios, Juan M., Ruano Raviña, Alberto, Siemiatycki, Jack, Koushik, Anita, Cote, Michele, Lazarus, Philip, Fernandez-Tardon, Guillermo, Tardon, Adonina, Le Marchand, Loïc, Brenner, Hermann, Saum, Kai-Uwe, Duell, Eric J., Andrew, Angeline S., Consonni, Dario, Olsson, Ann, Hung, Rayjean J., and Straif, Kurt

Published
2019
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27. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

Wan, Wenxin, primary, Peters, Susan, additional, Portengen, Lützen, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Ahrens, Wolfgang, additional, Schejbalova, Miriam, additional, Boffetta, Paolo, additional, Behrens, Thomas, additional, Brüning, Thomas, additional, Kendzia, Benjamin, additional, Consonni, Dario, additional, Demers, Paul A, additional, Fabiánová, Eleonóra, additional, Fernández-Tardón, Guillermo, additional, Field, John K., additional, Forastiere, Francesco, additional, Foretova, Lenka, additional, Guénel, Pascal, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Karrasch, Stefan, additional, Landi, Maria Teresa, additional, Lissowska, Jolanta, additional, Barul, Christine, additional, Mates, Dana, additional, McLaughlin, John R., additional, Merletti, Franco, additional, Migliore, Enrica, additional, Richiardi, Lorenzo, additional, Pándics, Tamás, additional, Pohlabeln, Hermann, additional, Siemiatycki, Jack, additional, Świątkowska, Beata, additional, Wichmann, Heinz-Erich, additional, Zaridze, David, additional, Ge, Calvin, additional, Straif, Kurt, additional, Kromhout, Hans, additional, and Vermeulen, Roel, additional

Published
2023
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32. Listening to the voice of children : systemic dialogue coaching : inviting participation and partnership in social work

Author

Olsson, Ann-Margreth E.

Subjects
362.7, systemic, dialogical, social work, dialogue, coaching, children, participatory action research, systemic practice, systemic research
Abstract

This is a study in and about systemic coaching in social work – systemic, and, as it unfolded, dialogical coaching, later named Dialogue Coaching (DC). Focus lies on what the conducted coaching brought forth, generated and created in the context of social work and for the members of the participating social welfare organisations. My specialities as coach became to inspire social workers to invite clients and especially children into partnership, making their voices heard, both in the written text and in the process of social investigations. The study was integral parts of commissions (and vice versa) of the County Administrative Board of Scania, Sweden, in my profession as systemic consultant and supervisor in Sweden. It was a study in how dialogical communication could improve how social workers, listening to the children’s invitation, could make children’s voices more heard in social investigations. In all, 55 social workers in seven municipalities participated in the dialogical participatory action research (DPAR) study, developing coaching and improving the dialogical interaction in social investigations. Focus moved from collecting data for decision-making, about what would be best for the child and other clients, to focusing on the changing process in relation to the participating clients, including children when they wanted to and could, co-creating new orientation on how to go on. The focus on communication and dialogue in the coaching changed and developed the participants’ approach in relation to clients and one another and others. In the emerging awareness of how we reciprocally and reflexively cocreate occurrences and outcomes, including who we become in relation to one another, the participating social workers’ awareness of the impact of their own contributions, and their own importance in relation to children and other clients, also improved. The expressions listening ears and listening questions were invented, capturing my, the coach’s, participation of placing myself completely 8 at the other participants’ disposal, completely accessible in the mutual responsiveness in the moment – being here and now in the present. The systemic methods and techniques were reflexively influenced and adapted from within the relational dynamic of joint actions in the dialogical interplay, metaphorically presented as peloton cycling in a voyage tour, becoming living tools in both the social workers’ practice and the coaching researcher’s practice, facilitating learning-by-doing with methods and approach connected to Appreciative Inquiry (AI). One of the living tools was reflecting teams emerging also into so called delta-reflecting teams with open narrating included.

Published
2010

36. Exposure–Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case–Control Studies

Author

Olsson, Ann C., Vermeulen, Roel, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Behrens, Thomas, Portengen, Lützen, Mirabelli, Dario, Gustavsson, Per, Kendzia, Benjamin, Almansa, Josue, Luzon, Veronique, Vlaanderen, Jelle, Stücker, Isabelle, Guida, Florence, Consonni, Dario, Caporaso, Neil, Landi, Maria Teresa, Field, John, Brüske, Irene, Wichmann, Heinz-Erich, Siemiatycki, Jack, Parent, Marie-Elise, Richiardi, Lorenzo, Merletti, Franco, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Plato, Nils, Tardón, Adonina, Zaridze, David, McLaughlin, John, Demers, Paul, Szeszenia-Dabrowska, Neonila, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Dumitru, Rodica Stanescu, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Brüning, Thomas, and Straif, Kurt

Published
2017

40. Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure–Effect Analyses Using a Quantitative Job Exposure Matrix

Author

Hall, Amy L., Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I., Curado, Maria Paula, Daudt, Alexander W., Fernandez, Leticia, Hashibe, Mia, Healy, Claire M., Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J., Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Yuan-Chin, Amy Lee, Znaor, Ariana, Straif, Kurt, and Olsson, Ann

Published
2020
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41. Testicular germ cell tumour risk by occupation and industry: a French case–control study – TESTIS

Author

Guth, Margot, primary, Coste, Astrid, additional, Lefevre, Marie, additional, Deygas, Floriane, additional, Danjou, Aurélie, additional, Ahmadi, Shukrullah, additional, Dananché, Brigitte, additional, Pérol, Olivia, additional, Boyle, Helen, additional, Schüz, Joachim, additional, Bujan, Louis, additional, Metzler-Guillemain, Catherine, additional, Giscard d’Estaing, Sandrine, additional, Teletin, Marius, additional, Ducrocq, Berengere, additional, Frapsauce, Cynthia, additional, Olsson, Ann, additional, Charbotel, Barbara, additional, and Fervers, Béatrice, additional

Published
2023
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43. Supplementary Table 1 from Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case–Control Study

Author

Togawa, Kayo, primary, Le Cornet, Charlotte, primary, Feychting, Maria, primary, Tynes, Tore, primary, Pukkala, Eero, primary, Hansen, Johnni, primary, Olsson, Ann, primary, Oksbjerg Dalton, Susanne, primary, Nordby, Karl-Christian, primary, Uuksulainen, Sanni, primary, Wiebert, Pernilla, primary, Woldbæk, Torill, primary, Skakkebæk, Niels E., primary, Fervers, Béatrice, primary, and Schüz, Joachim, primary

Published
2023
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44. Supplementary Table 2 from Parental Occupational Exposure to Heavy Metals and Welding Fumes and Risk of Testicular Germ Cell Tumors in Offspring: A Registry-Based Case–Control Study

Author

Togawa, Kayo, primary, Le Cornet, Charlotte, primary, Feychting, Maria, primary, Tynes, Tore, primary, Pukkala, Eero, primary, Hansen, Johnni, primary, Olsson, Ann, primary, Oksbjerg Dalton, Susanne, primary, Nordby, Karl-Christian, primary, Uuksulainen, Sanni, primary, Wiebert, Pernilla, primary, Woldbæk, Torill, primary, Skakkebæk, Niels E., primary, Fervers, Béatrice, primary, and Schüz, Joachim, primary

Published
2023
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47. O-106 Paternal occupational exposure to heavy metals and welding fumes and testicular germ cell tumors in sons in France

Author

Olsson, Ann, primary, Ahmadi, Shukrullah, additional, Guth, Margot, additional, Coste, Astrid, additional, Bouaoun, Liacine, additional, Danjou, Aurélie, additional, Lefevre, Marie, additional, Dananché, Brigitte, additional, Praud, Delphine, additional, Tongeren, Martie Van, additional, Bujan, Louis, additional, Pérol, Olivia, additional, Schüz, Joachim, additional, Charbotel, Barbara, additional, and Fervers, Béatrice, additional

Published
2023
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49. Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study

Author

Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, Charbotel, Barbara, Paul, Adèle, Danjou, Aurélie M N, Deygas, Floriane, Guth, Margot, Coste, Astrid, Lefevre, Marie, Dananché, Brigitte, Kromhout, Hans, Spinosi, Johan, Béranger, Rémi, Pérol, Olivia, Boyle, Helen, Hersant, Christel, Loup-Cabaniols, Vanessa, Veau, Ségolène, Bujan, Louis, Olsson, Ann, Schüz, Joachim, Fervers, Béatrice, and Charbotel, Barbara

Abstract

BACKGROUND: Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.METHODS: A case-control study was conducted, including 454 TGCT cases aged 18-45 from 20 French university hospitals, matched to 670 controls based on region and year of birth. Data collected from participants included parental jobs at birth coded according to the International Standard Classification of Occupation-1968 and the French nomenclature of activities-1999. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.RESULTS: Paternal jobs at birth as service workers (OR = 1.98, CI 1.18-3.30), protective service workers (OR = 2.40, CI 1.20-4.81), transport equipment operators (OR = 1.96, CI 1.14-3.37), specialized farmers (OR = 2.66, CI 1.03-6.90), and maternal jobs as secondary education teachers (OR = 2.27, CI 1.09-4.76) or in secondary education (OR = 2.35, CI 1.13-4.88) were significantly associated with adult TGCT. The risk of seminoma was increased for the above-mentioned paternal jobs and that of non-seminomas for public administration and defence; compulsory social security (OR = 1.99, CI 1.09-3.65); general, economic, and social administration (OR = 3.21, CI 1.23-8.39) for fathers; and secondary education teacher (OR = 4.67, CI 1.87-11.67) and secondary education (OR = 3.50, CI 1.36-9.01) for mothers.CONCLUSION: Some paternal jobs, such as service workers, transport equipment operators, or specialized farmers, and maternal jobs in secondary education seem to be associated with an increased risk of TGCT with specific features depending on the histological type. These data allow hypotheses to be put forward for further studies as to the invo

Published
2023

50. Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Author

Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Behrens, Thomas, Ge, Calvin, Vermeulen, Roel, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Pesch, Beate, Peters, Susan, Portengen, Lützen, Gustavsson, Per, Mirabelli, Dario, Guénel, Pascal, Luce, Danièle, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz Erich, Siemiatycki, Jack, Parent, Marie Elise, Richiardi, Lorenzo, Simonato, Lorenzo, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, McLaughlin, John R., Demers, Paul A., Świątkowska, Beata, Lissowska, Jolanta, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimír, Boffetta, Paolo, Bueno-de-Mesquita, Bas, Forastiere, Francesco, Straif, Kurt, and Brüning, Thomas

Abstract

There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates.

Published
2023

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