3,583 results on '"Olson, James"'
Search Results
2. Intelligence and the War on Terror: How Dirty Are We Willing to Get Our Hands?
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Olson, James M.
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- 2008
3. CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target
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Le, Quy, Hadland, Brandon, Smith, Jenny L, Leonti, Amanda, Huang, Benjamin J, Ries, Rhonda, Hylkema, Tiffany A, Castro, Sommer, Tang, Thao T, McKay, Cyd N, Perkins, LaKeisha, Pardo, Laura, Sarthy, Jay, Beckman, Amy K, Williams, Robin, Idemmili, Rhonda, Furlan, Scott, Ishida, Takashi, Call, Lindsey, Srivastava, Shivani, Loeb, Anisha M, Milano, Filippo, Imren, Suzan, Morris, Shelli M, Pakiam, Fiona, Olson, James M, Loken, Michael R, Brodersen, Lisa Eidenschink, Riddell, Stanley R, Tarlock, Katherine, Bernstein, Irwin D, Loeb, Keith R, and Meshinchi, Soheil
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Pediatric Research Initiative ,Pediatric ,Cancer ,Genetics ,Pediatric Cancer ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Human ,Stem Cell Research - Nonembryonic - Non-Human ,Biotechnology ,Hematology ,Rare Diseases ,Childhood Leukemia ,Orphan Drug ,2.1 Biological and endogenous factors ,Aetiology ,Animals ,Child ,Child ,Preschool ,Humans ,Infant ,Disease Models ,Animal ,Folate Receptor 1 ,Immunotherapy ,Adoptive ,Leukemia ,Megakaryoblastic ,Acute ,Oncogene Proteins ,Fusion ,T-Lymphocytes ,Transcriptome ,Xenograft Model Antitumor Assays ,Cancer immunotherapy ,Leukemias ,Oncogenes ,Oncology ,Therapeutics ,Medical and Health Sciences ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the transformation of human cord blood hematopoietic stem and progenitor cells (CB HSPCs) in an endothelial cell coculture system that recapitulates the transcriptome, morphology, and immunophenotype of C/G acute myeloid leukemia (AML) and induces highly aggressive leukemia in xenograft models. Interrogating the transcriptome of C/G-CB cells and primary C/G AML identified a library of C/G-fusion-specific genes that are potential targets for therapy. We developed chimeric antigen receptor (CAR) T cells directed against one of the targets, folate receptor α (FOLR1), and demonstrated their preclinical efficacy against C/G AML using in vitro and xenograft models. FOLR1 is also expressed in renal and pulmonary epithelium, raising concerns for toxicity that must be addressed for the clinical application of this therapy. Our findings underscore the role of the endothelial niche in promoting leukemic transformation of C/G-transduced CB HSPCs. Furthermore, this work has broad implications for studies of leukemogenesis applicable to a variety of oncogenic fusion-driven pediatric leukemias, providing a robust and tractable model system to characterize the molecular mechanisms of leukemogenesis and identify biomarkers for disease diagnosis and targets for therapy.
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- 2022
4. Fair play: The moral dilemmas of spying
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Olson, James M.
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BOOK REVIEWS - Published
- 2007
5. Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Hendrikse, Liam D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H, Erickson, Anders W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L, Shokouhian, Mohammad, Suárez, Raúl A, Ly, Michelle, Borlase, Stephanie, Scott, David S, Vladoiu, Maria C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y, Kumar, Sachin A, Balin, Polina, Visvanathan, Abhirami, Lee, John JY, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L, Luu, Betty, Bérubé, Pierre, Wang, Yu C, Pfister, Stefan M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J, Kros, Johan M, Zitterbart, Karel, Bailey, Swneke D, Eberhart, Charles G, Rao, Amulya AN, Giannini, Caterina, Olson, James M, Garami, Miklós, Hauser, Peter, Phillips, Joanna J, Ra, Young S, de Torres, Carmen, Mora, Jaume, Li, Kay KW, Ng, Ho-Keung, Poon, Wai S, Pollack, Ian F, López-Aguilar, Enrique, Gillespie, G Yancey, Van Meter, Timothy E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S, Van Meir, Erwin G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G, Faria, Claudia C, Roussel, Martine F, Boop, Frederick, Chan, Jennifer A, Aldinger, Kimberly A, Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E, and Thompson, Eric M
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Stem Cell Research ,Brain Disorders ,Neurosciences ,Rare Diseases ,Stem Cell Research - Nonembryonic - Non-Human ,Aetiology ,1.1 Normal biological development and functioning ,Underpinning research ,2.1 Biological and endogenous factors ,Cell Differentiation ,Cell Lineage ,Cerebellar Neoplasms ,Cerebellum ,Core Binding Factor alpha Subunits ,Hedgehog Proteins ,Histone Demethylases ,Humans ,Ki-67 Antigen ,Medulloblastoma ,Metencephalon ,Muscle Proteins ,Mutation ,Otx Transcription Factors ,Repressor Proteins ,T-Box Domain Proteins ,Transcription Factors ,General Science & Technology - Abstract
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.
- Published
- 2022
6. Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
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Przystal, Justyna, Cianciolo Cosentino, Chiara, Yadavilli, Sridevi, Zhang, Jie, Laternser, Sandra, Bonner, Erin, Prasad, Rachna, Dawood, Adam, Lobeto, Nina, Chin Chong, Wai, Biery, Matt, Myers, Carrie, Olson, James, Panditharatna, Eshini, Kritzer, Bettina, Mourabit, Sulayman, Vitanza, Nicholas, Filbin, Mariella, de Iuliis, Geoffry, Dun, Matthew, Koschmann, Carl, Cain, Jason, Grotzer, Michael, Waszak, Sebastian, Mueller, Sabine, and Nazarian, Javad
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ClpP ,ONC201 ,ONC206 ,diffuse midline glioma (DMG) ,integrated stress response (ISR) ,Animals ,Antineoplastic Agents ,Cell Line ,Tumor ,Cell Lineage ,Child ,Energy Metabolism ,Glioma ,Heterocyclic Compounds ,4 or More Rings ,Humans ,Mice ,Zebrafish - Abstract
BACKGROUND: Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. The imipridone ONC201 has shown early clinical efficacy in a subset of DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not been fully described in DMGs. METHODS: DMG models including primary human in vitro (n = 18) and in vivo (murine and zebrafish) models, and patient (n = 20) frozen and FFPE specimens were used. Drug-target engagement was evaluated using in silico ChemPLP and in vitro thermal shift assay. Drug toxicity and neurotoxicity were assessed in zebrafish models. Seahorse XF Cell Mito Stress Test, MitoSOX and TMRM assays, and electron microscopy imaging were used to assess metabolic signatures. Cell lineage differentiation and drug-altered pathways were defined using bulk and single-cell RNA-seq. RESULTS: ONC201 and ONC206 reduce viability of DMG cells in nM concentrations and extend survival of DMG PDX models (ONC201: 117 days, P = .01; ONC206: 113 days, P = .001). ONC206 is 10X more potent than ONC201 in vitro and combination treatment was the most efficacious at prolonging survival in vivo (125 days, P = .02). Thermal shift assay confirmed that both drugs bind to ClpP, with ONC206 exhibiting a higher binding affinity as assessed by in silico ChemPLP. ClpP activation by both drugs results in impaired tumor cell metabolism, mitochondrial damage, ROS production, activation of integrative stress response (ISR), and apoptosis in vitro and in vivo. Strikingly, imipridone treatment triggered a lineage shift from a proliferative, oligodendrocyte precursor-like state to a mature, astrocyte-like state. CONCLUSION: Targeting mitochondrial metabolism and ISR activation effectively impairs DMG tumorigenicity. These results supported the initiation of two pediatric clinical trials (NCT05009992, NCT04732065).
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- 2022
7. Effect of incubation conditions of cellulase hydrolysis on mechanical pulp fibre morphology
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Frias, Mariana, Reynoso, Santiago, Rambhia, Shriya, Noki, Gloria, Olson, James, Stoeber, Boris, and Trajano, Heather L.
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- 2024
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8. How Cancer Crossed the Color Line (review)
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Olson, James S.
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- 2011
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9. Unnatural History: Breast Cancer and American Society (review)
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Olson, James S.
- Published
- 2009
10. Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks
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Jaeger-Ruckstuhl, Carla A., Lo, Yun, Fulton, Elena, Waltner, Olivia G., Shabaneh, Tamer B., Simon, Sylvain, Muthuraman, Pranav V., Correnti, Colin E., Newsom, Oliver J., Engstrom, Ian A., Kanaan, Sami B., Bhise, Shruti S., Peralta, Jobelle M.C., Ruff, Raymond, Price, Jason P., Stull, Sylvia M., Stevens, Andrew R., Bugos, Grace, Kluesner, Mitchell G., Voillet, Valentin, Muhunthan, Vishaka, Morrish, Fionnuala, Olson, James M., Gottardo, Raphaël, Sarthy, Jay F., Henikoff, Steven, Sullivan, Lucas B., Furlan, Scott N., and Riddell, Stanley R.
- Published
- 2024
- Full Text
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11. Dietary Predictors of Urinary Biomarkers of Pyrethroids in the General Population – A Scoping Review
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Koyratty, Nadia, Olson, James R, Kawyn, Marissa, Curl, Cynthia L, and Kordas, Katarzyna
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- 2024
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12. Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma—and individual participant data meta-analysis (IPDMA)
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Wang, Shelly, Sun, Matthew Z, Abecassis, I Joshua, Weil, Alexander G, Ibrahim, George M, Fallah, Aria, Ene, Chibawanye, Leary, Sarah ES, Cole, Bonnie L, Lockwood, Christina M, Olson, James M, Geyer, J Russell, Ellenbogen, Richard G, Ojemann, Jeffrey G, and Wang, Anthony C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Cancer ,Good Health and Well Being ,Astrocytoma ,Brain Neoplasms ,Female ,Ganglioglioma ,Humans ,Infant ,Male ,Meningeal Carcinomatosis ,Neoplasm Recurrence ,Local ,BRAF ,Desmoplastic ,Infantile ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
PurposeDesmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are classified together as grade I neuronal and mixed neuronal-glial tumor of the central nervous system by the World Health Organization (WHO). These tumors are rare and have not been well characterized in terms of clinical outcomes. We aimed to identify clinical predictors of mortality and tumor recurrence/progression by performing an individual patient data meta-analysis (IPDMA) of the literature.MethodsA systematic literature review from 1970 to 2020 was performed, and individualized clinical data for patients diagnosed with DIA/DIG were extracted. Aggregated data were excluded from collection. Outcome measures of interest were mortality and tumor recurrence/progression, as well as time-to-event (TTE) for each of these. Participants without information on these outcome measures were excluded. Cox regression survival analyses were performed to determine predictors of mortality and tumor recurrence / progression.ResultsWe identified 98 articles and extracted individual patient data from 188 patients. The cohort consisted of 58.9% males with a median age of 7 months. The majority (68.1%) were DIGs, while 24.5% were DIAs and 7.5% were non-specific desmoplastic infantile tumors; DIAs presented more commonly in deep locations (p = 0.001), with leptomeningeal metastasis (p = 0.001), and was associated with decreased probability of gross total resection (GTR; p = 0.001). Gender, age, and tumor pathology were not statistically significant predictors of either mortality or tumor recurrence/progression. On multivariate survival analysis, GTR was a predictor of survival (HR = 0.058; p = 0.007) while leptomeningeal metastasis at presentation was a predictor of mortality (HR = 3.27; p = 0.025). Deep tumor location (HR = 2.93; p = 0.001) and chemotherapy administration (HR = 2.02; p = 0.017) were associated with tumor recurrence/progression.ConclusionOur IPDMA of DIA/DIG cases reported in the literature revealed that GTR was a predictor of survival while leptomeningeal metastasis at presentation was associated with mortality. Deep tumor location and chemotherapy were associated with tumor recurrence / progression.
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- 2021
13. Stuart Symington: A life
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Olson, James C.
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BOOK REVIEWS - Published
- 2006
14. Engineering the paper production by combined fiber fractionation and reinforcement with microfibrillated cellulose
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Seifert, Reanna, Gharehkhani, Samira, Vargas Figueroa, Daniela, Mercuur, Jordan, and Olson, James
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- 2023
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15. Polyvinyl-Alcohol Cellulose Fiber Foam as a Sustainable Greenhouse Growth Medium
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Bilek, Michael A., Meyer, Wilfred, Salem, Hayder J., Korehei, Reza, and Olson, James A.
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- 2023
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16. The transcriptional landscape of Shh medulloblastoma.
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Skowron, Patryk, Farooq, Hamza, Cavalli, Florence MG, Morrissy, A Sorana, Ly, Michelle, Hendrikse, Liam D, Wang, Evan Y, Djambazian, Haig, Zhu, Helen, Mungall, Karen L, Trinh, Quang M, Zheng, Tina, Dai, Shizhong, Stucklin, Ana S Guerreiro, Vladoiu, Maria C, Fong, Vernon, Holgado, Borja L, Nor, Carolina, Wu, Xiaochong, Abd-Rabbo, Diala, Bérubé, Pierre, Wang, Yu Chang, Luu, Betty, Suarez, Raul A, Rastan, Avesta, Gillmor, Aaron H, Lee, John JY, Zhang, Xiao Yun, Daniels, Craig, Dirks, Peter, Malkin, David, Bouffet, Eric, Tabori, Uri, Loukides, James, Doz, François P, Bourdeaut, Franck, Delattre, Olivier O, Masliah-Planchon, Julien, Ayrault, Olivier, Kim, Seung-Ki, Meyronet, David, Grajkowska, Wieslawa A, Carlotti, Carlos G, de Torres, Carmen, Mora, Jaume, Eberhart, Charles G, Van Meir, Erwin G, Kumabe, Toshihiro, French, Pim J, Kros, Johan M, Jabado, Nada, Lach, Boleslaw, Pollack, Ian F, Hamilton, Ronald L, Rao, Amulya A Nageswara, Giannini, Caterina, Olson, James M, Bognár, László, Klekner, Almos, Zitterbart, Karel, Phillips, Joanna J, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Liau, Linda M, Garami, Miklós, Hauser, Peter, Li, Kay Ka Wai, Ng, Ho-Keung, Poon, Wai Sang, Yancey Gillespie, G, Chan, Jennifer A, Jung, Shin, McLendon, Roger E, Thompson, Eric M, Zagzag, David, Vibhakar, Rajeev, Ra, Young Shin, Garre, Maria Luisa, Schüller, Ulrich, Shofuda, Tomoko, Faria, Claudia C, López-Aguilar, Enrique, Zadeh, Gelareh, Hui, Chi-Chung, Ramaswamy, Vijay, Bailey, Swneke D, Jones, Steven J, Mungall, Andrew J, Moore, Richard A, Calarco, John A, Stein, Lincoln D, Bader, Gary D, Reimand, Jüri, Ragoussis, Jiannis, Weiss, William A, Marra, Marco A, Suzuki, Hiromichi, and Taylor, Michael D
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Humans ,Medulloblastoma ,Cerebellar Neoplasms ,Signal Transduction ,Gene Expression Regulation ,Neoplastic ,Adolescent ,Adult ,Middle Aged ,Child ,Child ,Preschool ,Infant ,Female ,Male ,Hedgehog Proteins ,Gene Regulatory Networks ,Genetic Variation ,Young Adult ,Transcriptome ,Pediatric Research Initiative ,Brain Cancer ,Pediatric ,Rare Diseases ,Genetics ,Pediatric Cancer ,Clinical Research ,Brain Disorders ,Neurosciences ,Biotechnology ,Human Genome ,Cancer ,2.1 Biological and endogenous factors - Abstract
Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Furthermore, we discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several loss-of-function fusions in tumor suppressor genes PTCH1, SUFU and NCOR1. Molecular convergence on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma and open up opportunities for therapeutic intervention.
- Published
- 2021
17. Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma
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Noll, Alyssa, Myers, Carrie, Biery, Matthew C., Meechan, Michael, Tahiri, Sophie, Rajendran, Asmitha, Berens, Michael E., Paine, Danyelle, Byron, Sara, Zhang, Jiaming, Winter, Conrad, Pakiam, Fiona, Leary, Sarah E.S., Cole, Bonnie L., Jackson, Evangeline R., Dun, Matthew D., Foster, Jessica B., Evans, Myron K., Pattwell, Siobhan S., Olson, James M., and Vitanza, Nicholas A.
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- 2023
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18. Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
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Rusert, Jessica M, Juarez, Edwin F, Brabetz, Sebastian, Jensen, James, Garancher, Alexandra, Chau, Lianne Q, Tacheva-Grigorova, Silvia K, Wahab, Sameerah, Udaka, Yoko T, Finlay, Darren, Seker-Cin, Huriye, Reardon, Brendan, Gröbner, Susanne, Serrano, Jonathan, Ecker, Jonas, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia A, Henderson, Jacob J, Berens, Michael E, Vuori, Kristiina, Milde, Till, Cho, Yoon-Jae, Li, Xiao-Nan, Olson, James M, Reyes, Iris, Snuderl, Matija, Wong, Terence C, Dimmock, David P, Nahas, Shareef A, Malicki, Denise, Crawford, John R, Levy, Michael L, Van Allen, Eliezer M, Pfister, Stefan M, Tamayo, Pablo, Kool, Marcel, Mesirov, Jill P, and Wechsler-Reya, Robert J
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Clinical Sciences ,Oncology and Carcinogenesis ,Brain Disorders ,Neurosciences ,Pediatric ,Orphan Drug ,Biotechnology ,Genetic Testing ,Cancer ,Human Genome ,Pediatric Research Initiative ,Rare Diseases ,Brain Cancer ,Pediatric Cancer ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,Generic health relevance ,Good Health and Well Being ,Animals ,Antineoplastic Agents ,Cell Line ,Tumor ,Cerebellar Neoplasms ,Child ,Dactinomycin ,Gene Expression Regulation ,Neoplastic ,High-Throughput Screening Assays ,Humans ,Male ,Medulloblastoma ,Mice ,Inbred NOD ,Mutation ,Polymorphism ,Single Nucleotide ,Precision Medicine ,Exome Sequencing ,Xenograft Model Antitumor Assays ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterogeneity, most patients with medulloblastoma receive similar therapies, including surgery, radiation, and intensive chemotherapy. Although these treatments prolong survival, many patients still die from the disease and survivors suffer severe long-term side effects from therapy. We hypothesize that each patient with medulloblastoma is sensitive to different therapies and that tailoring therapy based on the molecular and cellular characteristics of patients' tumors will improve outcomes. To test this, we assembled a panel of orthotopic patient-derived xenografts (PDX) and subjected them to DNA sequencing, gene expression profiling, and high-throughput drug screening. Analysis of DNA sequencing revealed that most medulloblastomas do not have actionable mutations that point to effective therapies. In contrast, gene expression and drug response data provided valuable information about potential therapies for every tumor. For example, drug screening demonstrated that actinomycin D, which is used for treatment of sarcoma but rarely for medulloblastoma, was active against PDXs representing Group 3 medulloblastoma, the most aggressive form of the disease. Functional analysis of tumor cells was successfully used in a clinical setting to identify more treatment options than sequencing alone. These studies suggest that it should be possible to move away from a one-size-fits-all approach and begin to treat each patient with therapies that are effective against their specific tumor. SIGNIFICANCE: These findings show that high-throughput drug screening identifies therapies for medulloblastoma that cannot be predicted by genomic or transcriptomic analysis.
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- 2020
19. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma
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Nobre, Liana, Zapotocky, Michal, Khan, Sara, Fukuoka, Kohei, Fonseca, Adriana, McKeown, Tara, Sumerauer, David, Vicha, Ales, Grajkowska, Wieslawa A, Trubicka, Joanna, Li, Kay Ka Wai, Ng, Ho-Keung, Massimi, Luca, Lee, Ji Yeoun, Kim, Seung-Ki, Zelcer, Shayna, Vasiljevic, Alexandre, Faure-Conter, Cécile, Hauser, Peter, Lach, Boleslaw, van Veelen-Vincent, Marie-Lise, French, Pim J, Van Meir, Erwin G, Weiss, William A, Gupta, Nalin, Pollack, Ian F, Hamilton, Ronald L, Rao, Amulya A Nageswara, Giannini, Caterina, Rubin, Joshua B, Moore, Andrew S, Chambless, Lola B, Vibhakar, Rajeev, Ra, Young Shin, Massimino, Maura, McLendon, Roger E, Wheeler, Helen, Zollo, Massimo, Ferruci, Veronica, Kumabe, Toshihiro, Faria, Claudia C, Sterba, Jaroslav, Jung, Shin, López-Aguilar, Enrique, Mora, Jaume, Carlotti, Carlos G, Olson, James M, Leary, Sarah, Cain, Jason, Krskova, Lenka, Zamecnik, Josef, Hawkins, Cynthia E, Tabori, Uri, Huang, Annie, Bartels, Ute, Northcott, Paul A, Taylor, Michael D, Yip, Stephen, Hansford, Jordan R, Bouffet, Eric, and Ramaswamy, Vijay
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Cancer ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Antineoplastic Combined Chemotherapy Protocols ,Biomarkers ,Tumor ,Cerebellar Neoplasms ,Child ,Cyclophosphamide ,Female ,Humans ,Ifosfamide ,Male ,Medulloblastoma ,Middle Aged ,Neoplasm Recurrence ,Local ,Progression-Free Survival ,medulloblastoma ,WNT ,genomics ,cyclophosphamide ,chemotherapy ,prognosis ,survival - Abstract
Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.
- Published
- 2020
20. Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers
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Anger, W Kent, Farahat, Fayssal M, Lein, Pamela J, Lasarev, Michael R, Olson, James R, Farahat, Taghreed M, and Rohlman, Diane S
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Neurosciences ,Clinical Research ,Acetylcholinesterase ,Attention ,Butyrylcholinesterase ,Chlorpyrifos ,Egypt ,Executive Function ,Humans ,Male ,Neuropsychological Tests ,Occupational Exposure ,Pesticides ,Pyridones ,Organophosphorus pesticide ,OP ,Neurotoxicology ,Dose response ,Occupational exposure ,Toxicology ,Pharmacology and pharmaceutical sciences - Abstract
Chronic occupational exposure to organophosphorus pesticides (OPs) is consistently associated with deficits on behavioral tests when compared to unexposed comparison groups. However, a dose-response relationship has yet to be established, leading some to doubt an association between occupational OP exposure and behavioral deficits. Pesticide application teams in Egypt who are primarily exposed to one OP, chlorpyrifos (CPF), were recruited into a field assessment. Trail Making A and the more challenging Trail Making B tests were administered to 54 engineers (who supervise the pesticide application process, usually from the side of the field), 59 technicians (who guide the pesticide applicators in the field), 31 applicators (who mix and apply pesticides using knapsack sprayers), and 150 controls (who did not work in the fields) at two different times during the OP application season as well as immediately after applications had ended and 1.5 months later. All participants were males since only males work on pesticide application teams in Egypt. Urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy), a specific metabolite of CPF, confirmed the pattern of lower to higher CPF exposures from engineers to technicians to applicators, and these were all greater than urinary metabolite levels in controls. A consistent relationship between job title and performance speed on the behavioral task was observed: Controls had the best (fastest) performance on Trail Making A and B tests throughout the application season, and applicators had significantly slower performance than engineers on Trail Making A (p = 0.015) and B (p = 0.003). However, individual urinary TCPy, blood acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) levels did not predict individual performance. This study identifies a dose-related effect based on job title, which serves as a surrogate for chronic exposure in that differing job titles exhibit varying group exposure levels. The results establish that chronic occupational exposure to chlorpyrifos is neurotoxic and suggest that the classic biomarkers of recent CPF exposure are not predictive of chronic exposure effects.
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- 2020
21. Where the domino fell: America and Vietnam, 1945 to 1990
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Olson, James S. and Roberts, Randy
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BOOK REVIEWS - Published
- 1993
22. Evaluating how occupational exposure to organophosphates and pyrethroids impacts ADHD severity in Egyptian male adolescents
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Eadeh, Hana-May, Davis, Jonathan, Ismail, Ahmed A., Abdel Rasoul, Gaafar M., Hendy, Olfat M., Olson, James R., Bonner, Matthew R., and Rohlman, Diane S.
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- 2023
- Full Text
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23. Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics
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Nealy, Eric S., primary, Reed, Steven J., additional, Adelmund, Steven M., additional, Badeau, Barry A., additional, Shadish, Jared A., additional, Girard, Emily J., additional, Brasel, Kenneth, additional, Pakiam, Fiona J., additional, Mhyre, Andrew J., additional, Price, Jason P., additional, Sarkar, Surojit, additional, Kalia, Vandana, additional, DeForest, Cole A., additional, and Olson, James M., additional
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- 2024
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24. FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers
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Hoellerbauer, Pia, primary, Kufeld, Megan, additional, Arora, Sonali, additional, Mitchell, Kelly, additional, Girard, Emily J, additional, Herman, Jacob A, additional, Olson, James M, additional, and Paddison, Patrick J, additional
- Published
- 2024
- Full Text
- View/download PDF
25. Investigation of properties and applications of cellulose-mycelium foam
- Author
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Ahmadi, Hoda, O’Keefe, Amanda, Bilek, Michael A., Korehei, Reza, Sella Kapu, Nuwan, Martinez, Mark D., and Olson, James A.
- Published
- 2022
- Full Text
- View/download PDF
26. Preparation and benchmarking of novel cellulose nanopaper
- Author
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Kargupta, Wriju, Seifert, Reanna, Martinez, Mark, Olson, James, Tanner, Joanne, and Batchelor, Warren
- Published
- 2022
- Full Text
- View/download PDF
27. Social Cognition
- Author
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Higgins, E. Tory, primary, Kuiper, Nicholas A., additional, and Olson, James M., additional
- Published
- 2022
- Full Text
- View/download PDF
28. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse
- Author
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Zhang, Liguo, He, Xuelian, Liu, Xuezhao, Zhang, Feng, Huang, L Frank, Potter, Andrew S, Xu, Lingli, Zhou, Wenhao, Zheng, Tao, Luo, Zaili, Berry, Kalen P, Pribnow, Allison, Smith, Stephanie M, Fuller, Christine, Jones, Blaise V, Fouladi, Maryam, Drissi, Rachid, Yang, Zeng-Jie, Gustafson, W Clay, Remke, Marc, Pomeroy, Scott L, Girard, Emily J, Olson, James M, Morrissy, A Sorana, Vladoiu, Maria C, Zhang, Jiao, Tian, Weidong, Xin, Mei, Taylor, Michael D, Potter, S Steven, Roussel, Martine F, Weiss, William A, and Lu, Q Richard
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Genetics ,Cancer ,Stem Cell Research ,Rare Diseases ,Brain Cancer ,Stem Cell Research - Nonembryonic - Non-Human ,Stem Cell Research - Nonembryonic - Human ,Human Genome ,Biotechnology ,Neurosciences ,Pediatric ,Brain Disorders ,2.1 Biological and endogenous factors ,Aetiology ,Animals ,Brain Neoplasms ,Cell Line ,Tumor ,Cell Proliferation ,Cell Transformation ,Neoplastic ,Child ,Preschool ,Datasets as Topic ,Disease Models ,Animal ,Female ,Gene Expression Regulation ,Neoplastic ,Gene Knockdown Techniques ,Gene Regulatory Networks ,Hedgehog Proteins ,Humans ,Male ,Medulloblastoma ,Mice ,Transgenic ,Neoplasm Recurrence ,Local ,Neoplastic Stem Cells ,Neuroglia ,Oligodendrocyte Transcription Factor 2 ,Prognosis ,RNA-Seq ,Signal Transduction ,Single-Cell Analysis ,Survival Analysis ,Transcriptome ,AURORA-A/MYCN ,HIPPO-YAP/TAZ ,OLIG2 ,OPC-like ,glial progenitors ,medulloblastomas ,progenitor heterogeneity ,recurrent tumors ,single-cell transcriptomics ,sonic hedgehog (SHH) signaling ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Progenitor heterogeneity and identities underlying tumor initiation and relapse in medulloblastomas remain elusive. Utilizing single-cell transcriptomic analysis, we demonstrated a developmental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OLIG2-expressing glial progenitors as transit-amplifying cells at the tumorigenic onset. Although OLIG2+ progenitors become quiescent stem-like cells in full-blown tumors, they are highly enriched in therapy-resistant and recurrent medulloblastomas. Depletion of mitotic Olig2+ progenitors or Olig2 ablation impeded tumor initiation. Genomic profiling revealed that OLIG2 modulates chromatin landscapes and activates oncogenic networks including HIPPO-YAP/TAZ and AURORA-A/MYCN pathways. Co-targeting these oncogenic pathways induced tumor growth arrest. Together, our results indicate that glial lineage-associated OLIG2+ progenitors are tumor-initiating cells during medulloblastoma tumorigenesis and relapse, suggesting OLIG2-driven oncogenic networks as potential therapeutic targets.
- Published
- 2019
29. Where the domino fell: America and Vietnam, 1945 to 1990
- Author
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Olson, James S. and Roberts, Randy
- Subjects
BOOK REVIEWS - Published
- 1992
30. Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations
- Author
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Wang, Anthony C, Jones, David TW, Abecassis, Isaac Joshua, Cole, Bonnie L, Leary, Sarah ES, Lockwood, Christina M, Chavez, Lukas, Capper, David, Korshunov, Andrey, Fallah, Aria, Wang, Shelly, Ene, Chibawanye, Olson, James M, Geyer, J Russell, Holland, Eric C, Lee, Amy, Ellenbogen, Richard G, and Ojemann, Jeffrey G
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Rare Diseases ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Astrocytoma ,Child ,Preschool ,Female ,Ganglioglioma ,Humans ,Infant ,Male ,Mutation ,Neoplasm Recurrence ,Local ,Oncogene Proteins ,Fusion ,Proto-Oncogene Proteins B-raf ,Tumor Suppressor Protein p53 ,Exome Sequencing ,X-linked Nuclear Protein ,Developmental Biology ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Desmoplastic infantile ganglioglioma (DIG) and desmoplastic infantile astrocytoma (DIA) are extremely rare tumors that typically arise in infancy; however, these entities have not been well characterized in terms of genetic alterations or clinical outcomes. Here, through a multi-institutional collaboration, the largest cohort of DIG/DIA to date is examined using advanced laboratory and data processing techniques. Targeted DNA exome sequencing and DNA methylation profiling were performed on tumor specimens obtained from different patients (n = 8) diagnosed histologically as DIG/DIGA. Two of these cases clustered with other tumor entities, and were excluded from analysis. The remaining 16 cases were confirmed to be DIG/DIA by histology and by DNA methylation profiling. Somatic BRAF gene mutations were discovered in 7 instances (43.8%); 4 were BRAFV600E mutations, and 3 were BRAFV600D mutations. Three instances of malignant transformation were found, and sequencing of the recurrence demonstrated a new TP53 mutation in one case, new ATRX deletion in one case, and in the third case, the original tumor harbored an EML4-ALK fusion, also present at recurrence. DIG/DIA are distinct pathologic entities that frequently harbor BRAFV600 mutations. Complete surgical resection is the ideal treatment, and overall prognosis is excellent. While, the small sample size and incomplete surgical records limit a definitive conclusion about the risk of tumor recurrence, the risk appears quite low. In rare cases with wild-type BRAF, malignant progression can be observed, frequently with the acquisition of other genetic alterations.Implications: DIG/DIA are a distinct molecular entity, with a subset frequently harboring either BRAF V600E or BRAF V600D mutations. Mol Cancer Res; 16(10); 1491-8. ©2018 AACR.
- Published
- 2018
31. Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
- Author
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Malhi, Harman, Homad, Leah J., Wan, Yu-Hsin, Poudel, Bibhav, Fiala, Brooke, Borst, Andrew J., Wang, Jing Yang, Walkey, Carl, Price, Jason, Wall, Abigail, Singh, Suruchi, Moodie, Zoe, Carter, Lauren, Handa, Simran, Correnti, Colin E., Stoddard, Barry L., Veesler, David, Pancera, Marie, Olson, James, King, Neil P., and McGuire, Andrew T.
- Published
- 2022
- Full Text
- View/download PDF
32. Preclinical Analysis of JAA-F11, a Specific Anti–Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging
- Author
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Karacosta, Loukia G, Fisk, John C, Jessee, Joseph, Tati, Swetha, Turner, Bradley, Ghazal, Diala, Ludwig, Rachel, Johnson, Holly, Adams, Julia, Sajjad, Munawwar, Koury, Steven, Roy, Rene, Olson, James R, and Rittenhouse-Olson, Kate
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Breast Cancer ,Biochemistry and Cell Biology ,Clinical Sciences ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials. Wide tumor reactivity of JAA-F11, relative to the matched mouse IgG3 (control), was observed in 85% of 1269 cases of breast, lung, prostate, colon, bladder, and ovarian cancer. Staining on tissues from breast cancer cases was similar regardless of hormonal or Her2 status, and this is particularly important in finding a target on the currently untargetable triple-negative breast cancer subtype. Humanization of JAA-F11 was recently carried out as explained in a companion paper "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" (Neoplasia 19: 716-733, 2017), and it was confirmed that humanization did not affect chemical specificity. IHC studies with humanized JAA-F11 showed similar binding to human breast tumor tissues. In vivo imaging and biodistribution studies in a mouse syngeneic breast cancer model and in a mouse-human xenograft lung cancer model with humanized 124I- JAA-F11 construct confirmed in vitro tumor reactivity and specificity. In conclusion, the tumor reactivity of JAA-F11 supports the continued development of JAA-F11 as a targeted cancer therapeutic for multiple cancers, including those with unmet need.
- Published
- 2018
33. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
- Author
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Meehan, Terrence F, Conte, Nathalie, Goldstein, Theodore, Inghirami, Giorgio, Murakami, Mark A, Brabetz, Sebastian, Gu, Zhiping, Wiser, Jeffrey A, Dunn, Patrick, Begley, Dale A, Krupke, Debra M, Bertotti, Andrea, Bruna, Alejandra, Brush, Matthew H, Byrne, Annette T, Caldas, Carlos, Christie, Amanda L, Clark, Dominic A, Dowst, Heidi, Dry, Jonathan R, Doroshow, James H, Duchamp, Olivier, Evrard, Yvonne A, Ferretti, Stephane, Frese, Kristopher K, Goodwin, Neal C, Greenawalt, Danielle, Haendel, Melissa A, Hermans, Els, Houghton, Peter J, Jonkers, Jos, Kemper, Kristel, Khor, Tin O, Lewis, Michael T, Lloyd, KC Kent, Mason, Jeremy, Medico, Enzo, Neuhauser, Steven B, Olson, James M, Peeper, Daniel S, Rueda, Oscar M, Seong, Je Kyung, Trusolino, Livio, Vinolo, Emilie, Wechsler-Reya, Robert J, Weinstock, David M, Welm, Alana, Weroha, S John, Amant, Frédéric, Pfister, Stefan M, Kool, Marcel, Parkinson, Helen, Butte, Atul J, and Bult, Carol J
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Good Health and Well Being ,Animals ,Databases as Topic ,Disease Models ,Animal ,Humans ,Mice ,Neoplasms ,Patients ,Xenograft Model Antitumor Assays ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.
- Published
- 2017
34. Identifying and preventing the neurotoxic effects of pesticides
- Author
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Rohlman, Diane S., primary, Olson, James R., additional, Ismail, Ahmed A., additional, Bonner, Matthew R., additional, Abdel Rasoul, Gaafar, additional, and Hendy, Olfat, additional
- Published
- 2022
- Full Text
- View/download PDF
35. Recycling Paper-Plastic laminate coffee cups using a Single-Disk Refiner: Energy requirements and recovered fiber quality
- Author
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Bilek, Michael A., Salem, Hayder J., Korehei, Reza, and Olson, James A.
- Published
- 2021
- Full Text
- View/download PDF
36. Understanding the limits of screening operation. Part 2: Characterizing the operational window
- Author
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Villalba, Miguel E., primary, Olson, James A., additional, and Martinez, D. Mark, additional
- Published
- 2024
- Full Text
- View/download PDF
37. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments
- Author
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Kim, Dayoung, primary, Olson, James M., additional, and Cooper, Jonathan A., additional
- Published
- 2024
- Full Text
- View/download PDF
38. Temperature stability of urinary F2-isoprostane and 8-hydroxy-2′-deoxyguanosine
- Author
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Kordas, Katarzyna, primary, Ghazal, Diala, additional, Queirolo, Elena I., additional, Olson, James R., additional, Beledo, María Inés, additional, and Browne, Richard W., additional
- Published
- 2024
- Full Text
- View/download PDF
39. Understanding the limits of a screening operation. Part 1: Characterization of screen plugging
- Author
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Villalba, Miguel E., primary, Olson, James A., additional, and Martinez, D. Mark, additional
- Published
- 2024
- Full Text
- View/download PDF
40. CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect
- Author
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Crook, Zachary R., primary, Sevilla, Gregory P., additional, Young, Pamela, additional, Girard, Emily J., additional, Phi, Tinh-Doan, additional, Howard, Monique, additional, Olson, James M., additional, and Nairn, Natalie W., additional
- Published
- 2024
- Full Text
- View/download PDF
41. Systemically administered low-affinity HER2 CAR T cells mediate antitumor efficacy without toxicity
- Author
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Shabaneh, Tamer Basel, primary, Stevens, Andrew R, additional, Stull, Sylvia M, additional, Shimp, Kristen R, additional, Seaton, Brandon W, additional, Gad, Ekram A, additional, Jaeger-Ruckstuhl, Carla A, additional, Simon, Sylvain, additional, Koehne, Amanda L, additional, Price, Jason P, additional, Olson, James M, additional, Hoffstrom, Benjamin G, additional, Jellyman, David, additional, and Riddell, Stanley R, additional
- Published
- 2024
- Full Text
- View/download PDF
42. A first-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and safety in skin cancer patients
- Author
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Yamada, Miko, Miller, Dennis M., Lowe, Melinda, Rowe, Casey, Wood, Dominic, Soyer, H. Peter, Byrnes-Blake, Kelly, Parrish-Novak, Julia, Ishak, Laura, Olson, James M., Brandt, Gordon, Griffin, Paul, Spelman, Lynda, and Prow, Tarl W.
- Published
- 2021
- Full Text
- View/download PDF
43. Intertumoral Heterogeneity within Medulloblastoma Subgroups
- Author
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Cavalli, Florence MG, Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David JH, Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M, Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Rao, Amulya A Nageswara, Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G, Pollack, Ian F, Hamilton, Ronald L, Gillespie, G Yancey, Olson, James M, Leary, Sarah, Weiss, William A, Lach, Boleslaw, Chambless, Lola B, Thompson, Reid C, Cooper, Michael K, Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C, Kros, Johan M, French, Pim J, Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G, Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R, Rubin, Joshua B, Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E, Jung, Shin, Moore, Andrew S, Hallahan, Andrew R, Chan, Jennifer A, Tirapelli, Daniela PC, Carlotti, Carlos G, Fouladi, Maryam, Pimentel, José, Faria, Claudia C, Saad, Ali G, Massimi, Luca, Liau, Linda M, Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K, Perezpeña-Diazconti, Mario, de León, Fernando Chico Ponce, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E, Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B, Rutka, James T, Bader, Gary D, Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, and Taylor, Michael D
- Subjects
Genetics ,Rare Diseases ,Pediatric Cancer ,Cancer ,Brain Cancer ,Pediatric Research Initiative ,Pediatric ,Human Genome ,Brain Disorders ,Cluster Analysis ,Cohort Studies ,DNA Copy Number Variations ,DNA Methylation ,Gene Expression Profiling ,Genomics ,Humans ,Medulloblastoma ,Precision Medicine ,copy number ,gene expression ,integrative clustering ,medulloblastoma ,methylation ,subgroups ,Neurosciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
- Published
- 2017
44. Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival
- Author
-
Crotty, Erin E., Smith, Stephanie M. C., Brasel, Ken, Pakiam, Fiona, Girard, Emily J., Connor, Yamicia D., Zindy, Frederique, Mhyre, Andrew J., Roussel, Martine F., and Olson, James M.
- Published
- 2021
- Full Text
- View/download PDF
45. A tractable approximation for stochastic MPC and application to mechanical pulping processes
- Author
-
Tian, Hui, Prakash, Jagadeesan, Zavala, Victor M., Olson, James A., and Gopaluni, R. Bhushan
- Published
- 2020
- Full Text
- View/download PDF
46. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments.
- Author
-
Dayoung Kim, Olson, James M., and Cooper, Jonathan A.
- Subjects
- *
CELL migration , *CADHERINS , *GLIOMAS , *EXTRACELLULAR matrix , *BLOOD vessels - Abstract
Pediatric high-grade gliomas are highly invasive and essentially incurable. Glioma cells migrate between neurons and glia, along axon tracts, and through extracellular matrix surrounding blood vessels and underlying the pia. Mechanisms that allow adaptation to such complex environments are poorly understood. N-cadherin is highly expressed in pediatric gliomas and associated with shorter survival. We found that intercellular homotypic N-cadherin interactions differentially regulate glioma migration according to the microenvironment, stimulating migration on cultured neurons or astrocytes but inhibiting invasion into reconstituted or astrocyte-deposited extracellular matrix. N-cadherin localizes to filamentous connections between migrating leader cells but to epithelial-like junctions between followers. Leader cells have more surface and recycling N-cadherin, increased YAP1/TAZ signaling, and increased proliferation relative to followers. YAP1/TAZ signaling is dynamically regulated as leaders and followers change position, leading to altered N-cadherin levels and organization. Together, the results suggest that pediatric glioma cells adapt to different microenvironments by regulating N-cadherin dynamics and cell-cell contacts. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
47. Impact of chlorpyrifos exposure on lung function in Egyptian adolescent agriculture workers.
- Author
-
Mendez, Ernesto E., Davis, Jonathan, Bonner, Matthew R., Abdel Rasoul, Gaafar M., Ismail, Ahmed A., Hendy, Olfat M., Olson, James R., and Rohlman, Diane S.
- Abstract
Chlorpyrifos (CPF) is a widely used organophosphate insecticide that has been linked to detrimental health effects that range from neurological impacts to respiratory disease. The objective of this study was to assess respiratory symptoms associated with CPF exposure throughout the application season. Urine samples were collected from Egyptian adolescent applicators (n = 206) and non-applicators (n = 72) to assess 3,5,6-trichloro-2-pyridinol (TCPy), a biomarker for CPF exposure, along with spirometry measures to determine lung ventilatory function. Samples were collected over 7 months in 2016. Logistic regression was used to model the odds of reporting wheeze symptoms based on urinary TCPy concentrations while controlling for age and smoking in the household. Ordinal multinomial logistic regression was used to model the percent reference for forced expiratory volume in one second (rFEV
1 ) based on urinary TCPy concentration (µg/g creatinine). Wheezing increased with increasing pesticide exposure (OR = 1.74 (1.32 − 2.31)). There was no statistically significant relationship between rFEV1 and TCPy concentration. Efforts to reduce pesticide exposure should be implemented to prevent the potential onset or exacerbation of any linked respiratory complications in adolescents. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
48. Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation
- Author
-
Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H., Erickson, Anders W., Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L., Shokouhian, Mohammad, Suárez, Raúl A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Vladoiu, Maria C., Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L., Luu, Betty, Bérubé, Pierre, Wang, Yu C., Pfister, Stefan M., Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J., Kros, Johan M., Zitterbart, Karel, Bailey, Swneke D., Eberhart, Charles G., Rao, Amulya A. N., Giannini, Caterina, Olson, James M., Garami, Miklós, Hauser, Peter, Phillips, Joanna J., Ra, Young S., de Torres, Carmen, Mora, Jaume, Li, Kay K. W., Ng, Ho-Keung, Poon, Wai S., Pollack, Ian F., López-Aguilar, Enrique, Gillespie, G. Yancey, Van Meter, Timothy E., Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C., Cooper, Michael K., Rubin, Joshua B., Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S., Van Meir, Erwin G., Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G., Faria, Claudia C., Roussel, Martine F., Boop, Frederick, Chan, Jennifer A., Aldinger, Kimberly A., Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E., Thompson, Eric M., Ansari, Marc, Garre, Maria L., Chico, Fernando, Eguía, Pilar, Pérezpeña, Mario, Morrissy, A. Sorana, Cavalli, Florence M. G., Wu, Xiaochong, Daniels, Craig, Rich, Jeremy N., Jones, Steven J. M., Moore, Richard A., Marra, Marco A., Huang, Xi, Reimand, Jüri, Sorensen, Poul H., Wechsler-Reya, Robert J., Weiss, William A., Pugh, Trevor J., Garzia, Livia, Kleinman, Claudia L., Stein, Lincoln D., Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey A., Ellison, David W., Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E., Suzuki, Hiromichi, Millen, Kathleen J., and Taylor, Michael D.
- Published
- 2022
- Full Text
- View/download PDF
49. Eerdmans Commentary on the Bible: First Enoch
- Author
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Daniel C. Olson, James D. G. Dunn, John W. Rogerson and Daniel C. Olson, James D. G. Dunn, John W. Rogerson
- Published
- 2021
50. Circumventing colistin resistance by combining colistin and antimicrobial peptides to kill colistin-resistant and multidrug-resistant Gram-negative bacteria
- Author
-
Witherell, Kaitlin S., Price, Jason, Bandaranayake, Ashok D., Olson, James, and Call, Douglas R.
- Published
- 2020
- Full Text
- View/download PDF
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