1. Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)
- Author
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Olsen, EA, Harries, M, Tosti, A, Bergfeld, W, Blume-Peytavi, U, Callender, V, Chasapi, V, Correia, O, Cotsarelis, G, Dhurat, R, Dlova, N, Doche, I, Enechukwu, N, Grimalt, R, Itami, S, Hordinsky, M, Khobzei, K, Lee, W-S, Malakar, S, Messenger, A, McMichael, A, Mirmirani, P, Ovcharenko, Y, Papanikou, S, Pinto, GM, Piraccini, BM, Pirmez, R, Reygagne, P, Roberts, J, Rudnicka, L, Saceda-Corralo, D, Shapiro, J, Silyuk, T, Sinclair, R, Soares, RO, Souissi, A, Vogt, A, Washenik, K, Zlotogorski, A, Canfield, D, Vano-Galvan, S, Olsen, EA, Harries, M, Tosti, A, Bergfeld, W, Blume-Peytavi, U, Callender, V, Chasapi, V, Correia, O, Cotsarelis, G, Dhurat, R, Dlova, N, Doche, I, Enechukwu, N, Grimalt, R, Itami, S, Hordinsky, M, Khobzei, K, Lee, W-S, Malakar, S, Messenger, A, McMichael, A, Mirmirani, P, Ovcharenko, Y, Papanikou, S, Pinto, GM, Piraccini, BM, Pirmez, R, Reygagne, P, Roberts, J, Rudnicka, L, Saceda-Corralo, D, Shapiro, J, Silyuk, T, Sinclair, R, Soares, RO, Souissi, A, Vogt, A, Washenik, K, Zlotogorski, A, Canfield, D, and Vano-Galvan, S
- Abstract
BACKGROUND: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. OBJECTIVES: To enable data to be collected worldwide on FFA using common criteria and assessment methods. METHODS: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. RESULTS: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. CONCLUSIONS: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.
- Published
- 2021