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3. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Hemmes, Sabrine NT., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Uhlig, Christopher, Marín, Conrado Minguez, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Della Rocca, Giorgio, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe DJ., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Gil, Manuel Granell, Vidal Melo, Marcos F., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Ferrando, Carlos, Belda, Javier, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, Garcia del Valle, Santiago, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, Matta, Manuel de la, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Galve, Ana Isabel, Izquierdo, Ana, Jurado, Ana, Pérez, Ana María, Mugarra, Ana, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Román, Javie Ignacio, Acosta, Jesús, Rico-Feijoo, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., Pérez, Jose María, Marcos, Jose Miguel, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Mᵃ Justina, Tisner, Manuel, Barrio, María, Alonso, María Dolores, García, María, Hernández, María J., Alberola, María José, Parra, María, Argente, María Pilar, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Saleh Alfouzan, Rawan Abdullah, Alruqaie, Reef, Altermatt, Fernando, Luís de Castro Araujo, Bruno, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Tortosa, Isabel Belda, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Pérez, Elena Biosca, Birr, Katja, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Dincer, Pelin Corman, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, Junior, Paulo do Nascimento, Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Arı, Dilek Erdoğan, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Palahí, Christina Fortià, Galimberti, Andrea, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Ilić, Maja Karaman, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Barcelos, Gleicy Keli, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kivrak, Selin, Klarić, Vlasta, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Freitas de Lemos, Marília, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K., Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Pinheiro Módolo, Norma Sueli, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K., Murphy, Zoe, Nalwaya, Pramod, Naumovski, Filip, Navalesi, Paolo, Navarro e Lima, Lais Helena, Adam, Višnja Nesek, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, O'Connor, Michael, Oprea, Günther, Sungur, Mukadder Orhan, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Gonzalez, Estefania Palma, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Machado, Humberto S., Nunes, Catarina S., Sabbatini, Giovanni, Samuels, Jon D., Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Artiles, Tania Socorro, Castro, Diogo Sousa, Sousa, Miguel, Spadaro, Savino, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Altun, Gulbin Tore, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, Zhong, Jing, Campos, Niklas S., Librero, Julian, Ball, Lorenzo, and Serpa Neto, A.

Published
2022
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4. Comprehensive Characterization of a Porcine Model of The “Small-for-Flow” Syndrome

Author

Orue-Echebarria, Maitane I., Vaquero Martín, Francisco Javier, Lisbona, Cristina J., Lozano, Pablo, Steiner, Miguel A., Morales, Álvaro, López Baena, José Ángel, Laso, Juan, Hernández, Inmaculada, Olmedilla, Luis, García Sabrido, José Luis, Peligros Gómez, María Isabel, Sola Vendrell, Emma, Fernández Carballal, Carlos, Vara Ameigeiras, Elena María, Asencio Pascual, José Manuel, Orue-Echebarria, Maitane I., Vaquero Martín, Francisco Javier, Lisbona, Cristina J., Lozano, Pablo, Steiner, Miguel A., Morales, Álvaro, López Baena, José Ángel, Laso, Juan, Hernández, Inmaculada, Olmedilla, Luis, García Sabrido, José Luis, Peligros Gómez, María Isabel, Sola Vendrell, Emma, Fernández Carballal, Carlos, Vara Ameigeiras, Elena María, and Asencio Pascual, José Manuel

Abstract

Methods We performed subtotal (90%) hepatectomies in 10 female MiniPigs using a simplified transection technique with a tourniquet. Blood tests, hepatic and systemic hemodynamics, and hepatic function and histology were assessed before (Bas), 15 min (t-15 min) and 24 h (t-24 h) after the operation. Some pigs underwent computed tomography (CT) scans for hepatic volumetry (n = 4) and intracranial pressure (ICP) monitoring (n = 3). Postoperative care was performed in an intensive care unit environment. Results All hepatectomies were successfully performed, and hepatic volumetry confirmed liver remnant volumes of 9.2% [6.2–11.2]. The hepatectomy resulted in characteristic hepatic hemodynamic alterations, including portal hyperperfusion, relative decrease of hepatic arterial blood flow, and increased portal pressure (PP) and portal-systemic pressure gradient. The model reproduced major diagnostic features including the development of cholestasis, coagulopathy, encephalopathy with increased ICP, ascites, and renal failure, hyperdynamic circulation, and hyperlactatemia. Two animals (20%) died before t-24 h. Histological liver damage was observed at t-15 min and at t-24 h. The degree of histological damage at t-24 h correlated with intraoperative PP (r = 0.689, p = 0.028), hepatic arterial blood flow (r = 0.655, p = 0.040), and hepatic arterial pulsatility index (r = 0.724, p = 0.066). All animals with intraoperative PP > 20 mmHg presented liver damage at t-24 h. Conclusion The present 90% hepatectomy porcine experimental model is a feasible and reproducible model for investigating the “Small-for-Flow” syndrome., Sociedad Española de Trasplante Hepático (SETH), Instituto de Salud Carlos III, Depto. de Farmacología y Toxicología, Fac. de Veterinaria, TRUE, pub

Published
2024

5. Comparison of the hemodynamic effects of a single 5 mg/kg dose of lidocaine with or without epinephrine for thoracic paravertebral block.

Author

Garutti Martínez, Ignacio, Olmedilla, Luis, Cruz, Patricia, Piñeiro, Patricia, Gala Sánchez, Francisco De La, Cirujano, Ana, Garutti Martínez, Ignacio, Olmedilla, Luis, Cruz, Patricia, Piñeiro, Patricia, Gala Sánchez, Francisco De La, and Cirujano, Ana

Abstract

Background and objectives: Epinephrine is often added to local anesthetic solutions to minimize and slow the systemic absorption of local anesthetics, and thus reduce the possibility of adverse effects of these drugs. In an earlier study we found that the injection of 5 mg/kg of lidocaine via the paravertebral route depressed myocardial contractility by up to 30%, with practically no changes in heart rate or blood pressure. In the present study we investigated whether these alterations are due to systemic absorption of the local anesthetic, and whether such absorption can be minimized by adding epinephrine to the local anesthetic solution. Methods: A prospective, blind, and randomized study was made of 50 patients subjected to lung resection surgery. The subjects were divided into two groups: Lid group (5 mg/kg bolus dose of lidocaine in the thoracic paravertebral space) and Lid+E group (addition of 5 mcg/mL of epinephrine to the local anesthetic). The anesthetic solution was administered through a paravertebral catheter ipsilateral to the operative side. In addition to routine hemodynamic monitoring (heart rate and radial artery blood pressure), an aortic transpulmonary thermodilution catheter was inserted into the femoral artery for recording of the following variables: cardiac index, cardiac function index, maximum pressure derivative, global end diastolic volume, and intrathoracic total blood volume index. Data collection was carried out immediately before administration of the anesthetic solution and 15, 30, and 45 minutes after administration. Measurements were made of the plasma lidocaine levels at those same postparavertebral injection time points. Results: Prior to paravertebral dosing there were no differences in terms of the hemodynamic variables studied. However, 15 minutes after dosing in the Lid+E group, lesser reductions in contractility, cardiac function index, and cardiac index were recorded, compared with the Lid group, with a significant reduction, SOCIEDAD DE ANESTESIA Y REANIMACIÓN DE MADRID, Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub

Published
2024

6. Arterial oxygenation during one-lung ventilation: combined versus general anesthesia

Author

Garutti Martínez, Ignacio, Quintana Villamandos, María Begoña, Olmedilla, Luis, Cruz, Alberto, Barranco, Monica, García De Lucas, Elvira, Garutti Martínez, Ignacio, Quintana Villamandos, María Begoña, Olmedilla, Luis, Cruz, Alberto, Barranco, Monica, and García De Lucas, Elvira

Abstract

The optimal anesthetic management of patients undergoing thoracotomy for pulmonary resection has not been definitely determined. We evaluated whether general i.v. anesthesia (propofol-fentanyl) provides superior PaO2 during one-lung ventilation (OLV) compared with thoracic epidural anesthesia (TEA) with supplemental local and general anesthetics. We studied 60 patients who had prolonged periods of OLV for elective thoracic surgery for lung cancer and who were prospectively randomized into two groups. In 30 patients (GA group), fentanyl/propofol/rocuronium anesthesia was used. Another 30 patients (TEA group) were anesthetized with propofol/rocuronium/epidural thoracic bupivacaine 0.5%. A double-lumen endotracheal tube was inserted, and mechanical ventilation with 100% oxygen was used during the entire study. Arterial and venous blood gases were recorded before surgery in a lateral position with two-lung ventilation, 15 and 30 min after OLV (OLV + 15 and OLV + 30, respectively) in all patients. We measured PaO2, venous central oxygen tension, arterial and central venous oxygen saturation, venous admixture percentage (Qs/Qt%), and arterial and central venous oxygen content. The mean values for PaO2 during OLV in the GA group after 15 min (175 mm Hg) and 30 min (182 mm Hg) were significantly (P < 0.05) higher compared with the TEA group (120 and 118 mm Hg, respectively). Furthermore, Qs/Qt% was significantly (P < 0.05) increased in the TEA group during OLV. There were no other significant differences. We conclude that using the TEA regimen is associated with a lower PaO2 and a larger intrapulmonary shunt during OLV than with total i.v. anesthesia alone. Implications: Sixty patients undergoing elective lung surgery during a prolonged period of intraoperative one-lung ventilation were studied and randomized to receive general i.v. anesthesia or general i.v. anesthesia combined with thoracic epidural anesthesia. The arterial oxygenation in the first group was better than t, Depto. de Farmacología y Toxicología, Fac. de Medicina, FALSE, pub

Published
2024

7. Presence of methylated arginine derivatives in orthotopic human liver transplantation: Relevance for liver function

Author

Martín Sanz, Paloma, Olmedilla, Luis, Dulin, Elena, Casado, Marta, Callejas, Nuria A., Pérez Peña, José M., Garutti Martínez, Ignacio, Sanz, Javier M., Calleja, Javier, Barrigón Vázquez, Santos, Bosca Gomar, Lisardo, Martín Sanz, Paloma, Olmedilla, Luis, Dulin, Elena, Casado, Marta, Callejas, Nuria A., Pérez Peña, José M., Garutti Martínez, Ignacio, Sanz, Javier M., Calleja, Javier, Barrigón Vázquez, Santos, and Bosca Gomar, Lisardo

Abstract

Orthotopic liver transplantation (OLT) is a frequent option in the treatment of liver diseases. During the cold ischemia period of the donor liver, there is an accumulation of metabolites that are potent inhibitors of the cytokine-inducible and endothelial nitric oxide synthase isoenzymes. We identified the presence of L-N-monomethylarginine and asymmetric dimethylarginine (ADMA) as the main inhibitors by means of analytic high-pressure liquid chromatography and mass spectrometry techniques. An average ADMA concentration of 450 micromol/L was measured in the preservation medium of donor livers with poor outcomes after OLT. A statistically significant relationship was observed between the concentration of methylated arginine derivatives in the graft and liver function after OLT. These data suggest that measurement of methylated arginine, released after liver protein catabolism, might provide an indication of functional status of the liver that can help the development of strategies intended to improve graft viability., Universidad Complutense de Madrid, Comunidad de Madrid, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

8. Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation

Author

Olmedilla, Luis, Pérez Peña, José María, Ripoll, Cristina, Garutti Martínez, Ignacio, De Diego, Roberto, Salcedo Plaza, María Magdalena, Jiménez, Consuelo, Bañares Cañizares, Rafael, Olmedilla, Luis, Pérez Peña, José María, Ripoll, Cristina, Garutti Martínez, Ignacio, De Diego, Roberto, Salcedo Plaza, María Magdalena, Jiménez, Consuelo, and Bañares Cañizares, Rafael

Abstract

Early diagnosis of graft dysfunction in liver transplantation is essential for taking appropriate action. Indocyanine green clearance is closely related to liver function and can be measured noninvasively by spectrophotometry. The objectives of this study were to prospectively analyze the relationship between the indocyanine green plasma disappearance rate (ICGPDR) and early graft function after liver transplantation and to evaluate the role of ICGPDR in the prediction of severe graft dysfunction (SGD). One hundred seventy-two liver transplants from deceased donors were analyzed. Ten patients had SGD: 6 were retransplanted, and 4 died while waiting for a new graft. The plasma disappearance rate was measured 1 hour (PDRr60) and within the first 24 hours (PDR1) after reperfusion, and it was significantly lower in the SGD group. PDRr60 and PDR1 were excellent predictors of SGD. A threshold PDRr60 value of 10.8%/minute and a PDR1 value of 10%/minute accurately predicted SGD with areas under the receiver operating curve of 0.94 (95% confidence interval, 0.89-0.97) and 0.96 (95% confidence interval, 0.92-0.98), respectively. In addition, survival was significantly lower in patients with PDRr60 values below 10.8%/minute (53%, 47%, and 47% versus 95%, 94%, and 90% at 3, 6, and 12 months, respectively) and with PDR1 values below 10%/minute (62%, 62%, and 62% versus 94%, 92%, and 88%). In conclusion, very early noninvasive measurement of ICGPDR can accurately predict early severe graft dysfunction and mortality after liver transplantation., Depto. de Farmacología y Toxicología, Fac. de Medicina, TRUE, pub

Published
2024

9. Preconditioning by portal vein embolization modulates hepatic hemodynamics and improves liver function in pigs with extended hepatectomy

Author

Asencio Pascual, José Manuel, García Sabrido, José Luis, López Baena, José Ángel, Peligros Gómez, María Isabel, Sola Vendrell, Emma, Bañares Cañizares, Rafael, Vaquero Martín, Francisco Javier, Olmedilla, Luis, Lozano, Pablo, Morales-Taboada, Alvaro, Fernandez-Mena, Carolina, Steiner, Miguel Angel, Perez-Peña, Jose Maria, Herrero, Miriam, Laso, Juan, Lisbona, Cristina, Casanova, Javier, Asencio Pascual, José Manuel, García Sabrido, José Luis, López Baena, José Ángel, Peligros Gómez, María Isabel, Sola Vendrell, Emma, Bañares Cañizares, Rafael, Vaquero Martín, Francisco Javier, Olmedilla, Luis, Lozano, Pablo, Morales-Taboada, Alvaro, Fernandez-Mena, Carolina, Steiner, Miguel Angel, Perez-Peña, Jose Maria, Herrero, Miriam, Laso, Juan, Lisbona, Cristina, and Casanova, Javier

Abstract

Background. Portal vein embolization is performed weeks before extended hepatic resections to increase the future liver remnant and prevent posthepatectomy liver failure. Portal vein embolization performed closer to the operation also could be protective, but worsening of portal hyper-perfusion is a major concern. We determined the hepatic hemodynamic effects of a portal vein embolization performed 24 hours prior to hepatic operation. Methods. An extended (90%) hepatectomy was performed in swine undergoing (portal vein embolization) or not undergoing (control) a portal vein embolization 24 hours earlier (n = 10/group). Blood tests, hepatic and systemic hemodynamics, hepatic function (plasma disappearance rate of indocyanine green), liver histology, and volumetry (computed tomographic scanning) were assessed before and after the hepatectomy. Hepatocyte proliferating cell nuclear antigen expression and hepatic gene expression also were evaluated. Results. Swine in the control and portal vein embolization groups maintained stable systemic hemodynamics and developed similar increases of portal blood flow (302 ± 72% vs 486 ± 92%, P = .13). Portal pressure drastically increased in Controls (from 9.4 ± 1.3 mm Hg to 20.9 ± 1.4 mm Hg, P < .001), while being markedly attenuated in the portal vein embolization group (from 11.4 ± 1.5 mm Hg to 16.1 ± 1.3 mm Hg, P = .061). The procedure also improved the preservation of the hepatic artery blood flow, liver function, and periportal edema. These effects occurred in the absence of hepatocyte proliferation or hepatic growth and were associated with the induction of the vasoprotective gene Klf2. Conclusion. Portal vein embolization preconditioning represents a potential hepato-protective strategy for extended hepatic resections. Further preclinical studies should assess its medium-term effects, including survival. Our study also supports the relevance of hepatic hemodynamics as the main pathogenetic factor of post-hepatectomy liver fa, Mineco, ISCIII-Fondos FEDER, Sociedad Española de Trasplante Hepático, Depto. de Farmacología y Toxicología, Fac. de Veterinaria, TRUE, pub

Published
2024

12. Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial

Author

Acosta, Jesús, Aguilar, Gerardo, Alberola, María José, Alcón, Amalia, Alonso, Jose M., Alonso, María Dolores, Anaya, Rafael, Argente, María Pilar, Agilaga, Marta, Arocas, Blanca, Asensio, Ana, Ayas, Begoña, Ayuso, Mercedes, Balandrón, Victor, Barrio, María, Bejarano, Natalia, Benítez, Inmaculada, Cabrera, Sergio, Carbonell, Jose A., Carramiñana, Albert, Carrizo, Juan, Cegarra, Virginia, Chamorro, Estefanía, Charco, Pedro, Cruz, Patricia, Daviu, Francisco, De Fez, Mario, De Miguel, Ángeles, Del Río, Elena, Delgado, Carlos, Díaz, Ruben, Díaz, Susana, Díez, Fernando, Dosdá, Rosa, Duca, Alejandro, Etulain, M<ce:sup loc='post">a</ce:sup> Justina, Fernández, Carmen, Franco, Tania, Fuentes, Isabel, Gallego, Clara, Gallego-Casilda, Alberto, Galve, Ana Isabel, Garcés, Cristina, García, Mercedes, García, Pablo, Garrigues, Beatriz, Gilabert, Vicente, González, Domingo, Gutiérrez, Andrea, Hernández, Inmaculada, Izquierdo, Ana, Jurado, Ana, Katime, Antonio, Llamazares, Eduardo, Lardies, Rosa, Lisbona, Cristina, López-Herrera, Daniel, López, Ramiro, Lozano, Angels, Lozano, Elena, Marcos, Jose Miguel, Martin, Silvia, Martínez, Nilda, Martínez, Rocío, Martínez-Pallí, Graciella, Mazzinari, Guido, Miñana, Amanda, Moral, Victoria, Moreno, Tania, Mugarra, Ana, Muñoz, Lorena, Navarro, Jose, Olmedilla, Luis, Olmedo, Jonathan, Ojeda, Nazario, Parera, Ana, Parra, María, Parrilla, Cristina, Pastor, Ernesto, Peña, Natalia, Pérez, Ana María, Pérez, Jose María, Piqueras, Laura, Rico-Feijoo, Jesús, Rodríguez, Rayco, Román, Javier Ignacio, Romero, Antonio, Romero, Carolina, Romero, Esther, Ruiz, Isabel, Sánchez, Ester, Sandín, Francisco, Serralta, Ferran, Socorro, Tania, Soriano, Laura, Tisner, Manuel, Valencia, Lucia, Valls, Paola, Vaquero, Laura, Varón, Viviana, Vila, María, Villazala, Rubén, Villena, Abigail, Zapatero, Sara, Ferrando, Carlos, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Canet, Jaume, Librero, Julián, Pozo, Natividad, Peiró, Salvador, Llombart, Alicia, León, Irene, India, Inmaculada, Aldecoa, Cesar, Díaz-Cambronero, Oscar, Pestaña, David, Redondo, Francisco J, Garutti, Ignacio, Balust, Jaume, García, Jose I, Ibáñez, Maite, Granell, Manuel, Rodríguez, Aurelio, Gallego, Lucía, de la Matta, Manuel, Gonzalez, Rafael, Brunelli, Andrea, García, Javier, Rovira, Lucas, Barrios, Francisco, Torres, Vicente, Hernández, Samuel, Gracia, Estefanía, Giné, Marta, García, María, García, Nuria, Miguel, Lisset, Sánchez, Sergio, Piñeiro, Patricia, Pujol, Roger, García-del-Valle, Santiago, Valdivia, José, Hernández, María J, Padrón, Oto, Colás, Ana, Puig, Jaume, Azparren, Gonzalo, Tusman, Gerardo, Villar, Jesús, and Belda, Javier

Published
2018
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13. Preconditioning by portal vein embolization modulates hepatic hemodynamics and improves liver function in pigs with extended hepatectomy

Author

Asencio, José M., García-Sabrido, José L., López-Baena, José A., Olmedilla, Luis, Peligros, Isabel, Lozano, Pablo, Morales-Taboada, Álvaro, Fernández-Mena, Carolina, Steiner, Miguel A., Sola, Emma, Perez-Peña, José M., Herrero, Miriam, Laso, Juan, Lisbona, Cristina, Bañares, Rafael, Casanova, Javier, and Vaquero, Javier

Published
2017
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15. Effect of intraoperative paravertebral or intravenous lidocaine versus control during lung resection surgery on postoperative complications: A randomized controlled trial

Author

De la Gala, Francisco, Piñeiro, Patricia, Reyes, Almudena, Simón, Carlos, Vara, Elena, Rancan, Lisa, Huerta, Luis Javier, Gonzalez, Guillermo, Benito, Carmen, Muñoz, Marta, Grande, Pilar, Paredes, Sergio D., Aznar, Pablo Tomas, Perez, Alvaro, Martinez, David, Higuero, Fernando, Sanz, David, De Miguel, Juan Pedro, Cruz, Patricia, Olmedilla, Luis, Lopez Gil, Elena, Duque, Patricia, Sanchez-Pedrosa, Guillermo, Valle, Mayte, and Garutti, Ignacio

Published
2019
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20. Mecanismos del precondicionamiento regenerativo en hepatectomías subtotales en modelo porcino

Author

Orue-Echebarria, Maitane I., primary, Vaquero, Javier, additional, Vara, Elena, additional, Rancan, Lisa, additional, Lozano, Pablo, additional, Lisbona, Cristina J., additional, Laso, Juan, additional, Fernández-Mena, Carolina, additional, Olmedilla, Luis, additional, Peligros, Isabel, additional, García-Sabrido, José L., additional, and Asencio, José M., additional

Published
2022
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21. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Campos, Niklas S., primary, Bluth, Thomas, additional, Hemmes, Sabrine N.T., additional, Librero, Julian, additional, Pozo, Natividad, additional, Ferrando, Carlos, additional, Ball, Lorenzo, additional, Mazzinari, Guido, additional, Pelosi, Paolo, additional, Gama de Abreu, Marcelo, additional, Schultz, Marcus J., additional, Serpa Neto, A., additional, Hemmes, Sabrine NT., additional, Severgnini, Paolo, additional, Hollmann, Markus W., additional, Binnekade, Jan M., additional, Wrigge, Hermann, additional, Canet, Jaume, additional, Hiesmayr, Michael, additional, Schmid, Werner, additional, Tschernko, Edda, additional, Jaber, Samir, additional, Hedenstierna, Göran, additional, Putensen, Christian, additional, Marti, Agnes, additional, Bacuzzi, Alessandro, additional, Brodhun, Alexander, additional, Molin, Alexandre, additional, Merten, Alfred, additional, Parera, Ana, additional, Brunelli, Andrea, additional, Cortegiani, Andrea, additional, Güldner, Andreas, additional, Reske, Andreas W., additional, Gratarola, Angelo, additional, Giarratano, Antonino, additional, Bastin, Bea, additional, Heyse, Bjorn, additional, Mazul-Sunko, Branka, additional, Amantea, Bruno, additional, Barberis, Bruno, additional, Uhlig, Christopher, additional, Marín, Conrado Minguez, additional, Celentano, Cristian, additional, La Bella, Daniela, additional, D’Antini, David, additional, Velghe, David, additional, Sulemanji, Demet, additional, De Robertis, Edoardo, additional, Hartmann, Eric, additional, Montalto, Francesca, additional, Tropea, Francesco, additional, Mills, Gary H., additional, Cinnella, Gilda, additional, Della Rocca, Giorgio, additional, Caggianelli, Girolamo, additional, Pellerano, Giulia, additional, Mollica, Giuseppina, additional, Bugedo, Guillermo, additional, Mulier, Jan-Paul, additional, Vandenbrande, Jeroen, additional, Geib, Johann, additional, Yaqub, Jonathan, additional, Florez, Jorge, additional, Mayoral, Juan F., additional, Sprung, Juraj, additional, Van Limmen, Jurgen, additional, Bos, Lieuwe DJ., additional, de Baerdemaeker, Luc, additional, Jamaer, Luc, additional, Spagnolo, Luigi, additional, Strys, Lydia, additional, Gil, Manuel Granell, additional, Vidal Melo, Marcos F., additional, Unzueta, Maria Carmen, additional, Moral, Maria Victoria, additional, Ferner, Marion, additional, Weiss, Martin, additional, Vanoni, Massimo, additional, Schaefer, Maximilian S., additional, Prieto, Mercè, additional, Grio, Michele, additional, Spieth, Peter Markus, additional, Simon, Philipp, additional, Bodger, Phoebe, additional, Sierra, Pilar, additional, Laufenberg-Feldmann, Rita, additional, Rusca, Roberta, additional, Proietti, Rodolfo, additional, Raineri, Santi Maurizio, additional, Caroleo, Santo, additional, Sabaté, Sergi, additional, De Hert, Stefan, additional, Pezzato, Stefano, additional, Treschan, Tanja A., additional, Goranovic, Tatjana, additional, Koch, Thea, additional, Kiss, Thomas, additional, Perilli, Valter, additional, Cegarra, Virginia, additional, Belda, Javier, additional, Soro, Marina, additional, Unzueta, Carmen, additional, Suarez-Sipmann, Fernando, additional, Librero, Julián, additional, Llombart, Alicia, additional, Rovira, Lucas, additional, Granell, Manuel, additional, Aldecoa, César, additional, Diaz-Cambronero, Oscar, additional, Balust, Jaume, additional, Garutti, Ignacio, additional, Gonzalez, Rafael, additional, Gallego, Lucia, additional, Garcia del Valle, Santiago, additional, Redondo, Javier, additional, Pestaña, David, additional, Rodríguez, Aurelio, additional, García, Javier, additional, Matta, Manuel de la, additional, Ibáñez, Maite, additional, Barrios, Francisco, additional, Hernández, Samuel, additional, Torres, Vicente, additional, Peiró, Salvador, additional, Villena, Abigail, additional, Carramiñana, Albert, additional, Gallego-Casilda, Alberto, additional, Duca, Alejandro, additional, Alcón, Amalia, additional, Miñana, Amanda, additional, Asensio, Ana, additional, Colás, Ana, additional, Galve, Ana Isabel, additional, Izquierdo, Ana, additional, Jurado, Ana, additional, Pérez, Ana María, additional, Mugarra, Ana, additional, Gutierrez, Andrea, additional, De Miguel, Ángeles, additional, Lozano, Angels, additional, Katime, Antonio, additional, Romero, Antonio, additional, Garrigues, Beatriz, additional, Ayas, Begoña, additional, Arocas, Blanca, additional, Delgado, Carlos, additional, Fernández, Carmen, additional, Romero, Carolina, additional, Gallego, Clara, additional, Garcés, Cristina, additional, Lisbona, Cristina, additional, Parrilla, Cristina, additional, López-Herrera, Daniel, additional, González, Domingo, additional, Llamazares, Eduardo, additional, Del Rio, Elena, additional, Lozano, Elena, additional, Pastor, Ernesto, additional, Chamorro, Estefanía, additional, Gracia, Estefanía, additional, Sánchez, Ester, additional, Romero, Esther, additional, Díez, Fernando, additional, Serralta, Ferran, additional, Daviu, Francisco, additional, Sandín, Francisco, additional, Aguilar, Gerardo, additional, Tusman, Gerardo, additional, Azparren, Gonzalo, additional, Martínez-Pallí, Graciela, additional, Benítez, Inmaculada, additional, Hernandéz, Inmaculada, additional, India, Inmaculada, additional, León, Irene, additional, Fuentes, Isabel, additional, Ruiz, Isabel, additional, Puig, Jaume, additional, Román, Javie Ignacio, additional, Acosta, Jesús, additional, Rico-Feijoo, Jesús, additional, Olmedo, Jonathan, additional, Carbonell, Jose A., additional, Alonso, Jose M., additional, Pérez, Jose María, additional, Marcos, Jose Miguel, additional, Navarro, Jose, additional, Valdivia, Jose, additional, Carrizo, Juan, additional, Piqueras, Laura, additional, Soriano, Laura, additional, Vaquero, Laura, additional, Miguel, Lisset, additional, Muñoz, Lorena, additional, Valencia, Lucia, additional, Olmedilla, Luis, additional, Etulain, Mᵃ Justina, additional, Tisner, Manuel, additional, Barrio, María, additional, Alonso, María Dolores, additional, García, María, additional, Hernández, María J., additional, Alberola, María José, additional, Parra, María, additional, Argente, María Pilar, additional, Vila, María, additional, De Fez, Mario, additional, Agilaga, Marta, additional, Gine, Marta, additional, Ayuso, Mercedes, additional, García, Mercedes, additional, Bejarano, Natalia, additional, Peña, Natalia, additional, Ojeda, Nazario, additional, Martínez, Nilda, additional, García, Nuria, additional, Padrón, Oto, additional, García, Pablo, additional, Valls, Paola, additional, Cruz, Patricia, additional, Piñeiro, Patricia, additional, Charco, Pedro, additional, Anaya, Rafael, additional, López, Ramiro, additional, Rodríguez, Rayco, additional, Martínez, Rocío, additional, Pujol, Roger, additional, Dosdá, Rosa, additional, Lardies, Rosa, additional, Díaz, Ruben, additional, Villazala, Rubén, additional, Zapatero, Sara, additional, Cabrera, Sergio, additional, Sánchez, Sergio, additional, Martin, Silvia, additional, Diaz, Suzana, additional, Franco, Tania, additional, Moreno, Tania, additional, Socorro, Tania, additional, Gilabert, Vicente, additional, Balandrón, Victor, additional, Moral, Victoria, additional, Cegarra, Virgina, additional, Varón, Viviana, additional, Abelha, Fernando, additional, Abitağaoğlu, Sühayla, additional, Achilles, Marc, additional, Adebesin, Afeez, additional, Adriaensens, Ine, additional, Ahene, Charles, additional, Akbar, Fatima, additional, Al Harbi, Mohammed, additional, Al Khoury al Kallab, Rita, additional, Albanel, Xavier, additional, Aldenkortt, Florence, additional, Saleh Alfouzan, Rawan Abdullah, additional, Alruqaie, Reef, additional, Altermatt, Fernando, additional, Luís de Castro Araujo, Bruno, additional, Arbesú, Genaro, additional, Artsi, Hanna, additional, Aurilio, Caterina, additional, Ayanoglu, Omer Hilmi, additional, Baig, Harris, additional, Baird, Yolanda, additional, Balonov, Konstantin, additional, Banks, Samantha, additional, Bao, Xiaodong, additional, Baumgartner, Mélanie, additional, Tortosa, Isabel Belda, additional, Bergamaschi, Alice, additional, Bergmann, Lars, additional, Bigatello, Luca, additional, Pérez, Elena Biosca, additional, Birr, Katja, additional, Bojaxhi, Elird, additional, Bonenti, Chiara, additional, Bonney, Iwona, additional, Bos, Elke M.E., additional, Bowman, Sara, additional, Braz, Leandro Gobbo, additional, Brugnoni, Elisa, additional, Brull, Sorin J., additional, Brunetti, Iole, additional, Bruni, Andrea, additional, Buenvenida, Shonie L., additional, Busch, Cornelius Johannes, additional, Camerini, Giovanni, additional, Capatti, Beatrice, additional, Carmona, Javiera, additional, Carungcong, Jaime, additional, Carvalho, Marta, additional, Cattan, Anat, additional, Cavaleiro, Carla, additional, Chiumello, Davide, additional, Ciardo, Stefano, additional, Coburn, Mark, additional, Colella, Umberto, additional, Contreras, Victor, additional, Dincer, Pelin Corman, additional, Cotter, Elizabeth, additional, Crovetto, Marcia, additional, Darrah, William, additional, Davies, Simon, additional, Del Cojo Peces, Enrique, additional, Delphin, Ellise, additional, Diaper, John, additional, Junior, Paulo do Nascimento, additional, Donatiello, Valerio, additional, Dong, Jing, additional, Dourado, Maria do Socorro, additional, Dullenkopf, Alexander, additional, Ebner, Felix, additional, Elgendy, Hamed, additional, Ellenberger, Christoph, additional, Arı, Dilek Erdoğan, additional, Ermert, Thomas, additional, Farah, Fadi, additional, Fernandez-Bustamante, Ana, additional, Ferreira, Cristina, additional, Fiore, Marco, additional, Fonte, Ana, additional, Palahí, Christina Fortià, additional, Galimberti, Andrea, additional, Garofano, Najia, additional, Giaccari, Luca Gregorio, additional, Gilsanz, Fernando, additional, Girrbach, Felix, additional, Gobbi, Luca, additional, Godfried, Marc Bernard, additional, Goettel, Nicolai, additional, Goldstein, Peter A., additional, Goren, Or, additional, Gorlin, Andrew, additional, Graterol, Juan, additional, Guyon, Pierre, additional, Haire, Kevin, additional, Harou, Philippe, additional, Helf, Antonia, additional, Hempel, Gunther, additional, Hernández Cádiz, María José, additional, Heyse, Björn, additional, Huercio, Ivan, additional, Ilievska, Jasmina, additional, Jakus, Lien, additional, Jeganath, Vijay, additional, Jelting, Yvonne, additional, Jung, Minoa, additional, Kabon, Barbara, additional, Kacha, Aalok, additional, Ilić, Maja Karaman, additional, Karuppiah, Arunthevaraja, additional, Kavas, Ayse Duygu, additional, Barcelos, Gleicy Keli, additional, Kellogg, Todd A., additional, Kemper, Johann, additional, Kerbrat, Romain, additional, Khodr, Suraya, additional, Kienbaum, Peter, additional, Kir, Bunyamin, additional, Kivrak, Selin, additional, Klarić, Vlasta, additional, Köksal, Ceren, additional, Kowark, Ana, additional, Kranke, Peter, additional, Kuvaki, Bahar, additional, Kuzmanovska, Biljana, additional, Laffey, John, additional, Lange, Mirko, additional, Freitas de Lemos, Marília, additional, Licker, Marc-Joseph, additional, López-Baamonde, Manuel, additional, López-Hernández, Antonio, additional, Lopez-Martinez, Mercedes, additional, Luise, Stéphane, additional, MacGregor, Mark, additional, Magalhães, Danielle, additional, Maillard, Julien, additional, Malerbi, Patrizia, additional, Manimekalai, Natesan, additional, Margarson, Michael, additional, Markstaller, Klaus, additional, Martin, Archer K., additional, Martin, David P., additional, Martin, Yvette N., additional, Martínez-Ocon, Julia, additional, Martin-Loeches, Ignacio, additional, Maseda, Emilio, additional, Matot, Idit, additional, McAuliffe, Niamh, additional, McKenzie, Travis J., additional, Medina, Paulina, additional, Meersch, Melanie, additional, Menzen, Angelika, additional, Mertens, Els, additional, Meurer, Bernd, additional, Meyer-Treschan, Tanja, additional, Miao, Changhong, additional, Micalizzi, Camilla, additional, Milić, Morena, additional, Pinheiro Módolo, Norma Sueli, additional, Moine, Pierre, additional, Mölders, Patrick, additional, Montero-Feijoo, Ana, additional, Moret, Enrique, additional, Muller, Markus K., additional, Murphy, Zoe, additional, Nalwaya, Pramod, additional, Naumovski, Filip, additional, Navalesi, Paolo, additional, Navarro e Lima, Lais Helena, additional, Adam, Višnja Nesek, additional, Neumann, Claudia, additional, Newell, Christopher, additional, Nisnevitch, Zoulfira, additional, Nizamuddin, Junaid, additional, Novazzi, Cecilia, additional, O'Connor, Michael, additional, Oprea, Günther, additional, Sungur, Mukadder Orhan, additional, Özbilgin, Şule, additional, Pace, Maria Caterina, additional, Pacheco, Marcos, additional, Packianathaswamy, Balaji, additional, Gonzalez, Estefania Palma, additional, Papaspyros, Fotios, additional, Paredes, Sebastián, additional, Passavanti, Maria Beatrice, additional, Pedemonte, Juan Cristobal, additional, Peremin, Sanja, additional, Philipsenburg, Christoph, additional, Pinho, Daniela, additional, Pinho, Silvia, additional, Posthuma, Linda M., additional, Pota, Vincenzo, additional, Preckel, Benedikt, additional, Priani, Paolo, additional, Rached, Mohamed Aymen, additional, Radoeshki, Aleksandar, additional, Ragazzi, Riccardo, additional, Rajamanickam, Tamilselvan, additional, Rajamohan, Arthi, additional, Ramakrishna, Harish, additional, Rangarajan, Desikan, additional, Reiterer, Christian, additional, Renew, J. Ross, additional, Reynaud, Thomas, additional, Rhys, Rhidian, additional, Rivas, Eva, additional, Robitzky, Luisa, additional, Rossaint, Rolf, additional, Rubulotta, Francesca, additional, Machado, Humberto S., additional, Nunes, Catarina S., additional, Sabbatini, Giovanni, additional, Samuels, Jon D., additional, Sanahuja, Josep Martí, additional, Sansone, Pasquale, additional, Santos, Alice, additional, Sayedalahl, Mohamed, additional, Scharffenberg, Martin, additional, Schiffer, Eduardo, additional, Schliewe, Nadja, additional, Schorer, Raoul, additional, Schumann, Roman, additional, Selmo, Gabriele, additional, Sendra, Mar, additional, Senturk, Mert, additional, Shaw, Kate, additional, Shosholcheva, Mirjana, additional, Sibai, Abdulrazak, additional, Simonassi, Francesca, additional, Sinno, Claudia, additional, Sivrikoz, Nukhet, additional, Skandalou, Vasiliki, additional, Smith, Neil, additional, Soares, Maria, additional, Artiles, Tania Socorro, additional, Castro, Diogo Sousa, additional, Sousa, Miguel, additional, Spadaro, Savino, additional, Stamatakis, Emmanouil, additional, Steiner, Luzius A., additional, Stevenazzi, Andrea, additional, Suarez-de-la-Rica, Alejandro, additional, Suppan, Mélanie, additional, Teichmann, Robert, additional, Tena Guerrero, José Maria, additional, Thiel, Bram, additional, Tolós, Raquel, additional, Altun, Gulbin Tore, additional, Tucci, Michelle, additional, Turnbull, Zachary A., additional, Turudić, Žana, additional, Unterberg, Matthias, additional, Van Nieuwenhove, Yves, additional, Van Waesberghe, Julia, additional, Vidal Melo, Marcos Francisco, additional, Vitković, Bibiana, additional, Vivona, Luigi, additional, Vizcaychipi, Marcela, additional, Volta, Carlo Alberto, additional, Weber, Anne, additional, Weingarten, Toby N., additional, Wittenstein, Jakob, additional, Wyffels, Piet, additional, Yagüe, Julio, additional, Yates, David, additional, Yavru, Ayşen, additional, Zac, Lilach, additional, and Zhong, Jing, additional

Published
2022
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26. Mechanisms of regenerative preconditioning in pigs with subtotal hepatectomies.

Author

Orue-Echebarria, Maitane I., Vaquero, Javier, Vara, Elena, Rancan, Lisa, Lozano, Pablo, Lisbona, Cristina J., Laso, Juan, Fernández-Mena, Carolina, Olmedilla, Luis, Peligros, Isabel, García-Sabrido, José L., and Asencio, José M.

Subjects
REGENERATIVE medicine, PORTAL vein, HEPATECTOMY, SWINE anatomy, ENERGY metabolism
Abstract

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Published
2022
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30. Intraoperative Troponin Elevation in Liver Transplantation Is Independently Associated With Mortality: A Prospective Observational Study

Author

Vilchez‐Monge, Almudena L., primary, Garutti, Ignacio, additional, Jimeno, Concepción, additional, Zaballos, Matilde, additional, Jimenez, Consuelo, additional, Olmedilla, Luis, additional, Piñeiro, Patricia, additional, Duque, Patricia, additional, Salcedo, Magdalena, additional, Asencio, Jose M., additional, Lopez‐Baena, Jose A, additional, Maruszewski, Przemyslaw, additional, Bañares, Rafael, additional, and Perez‐Peña, Jose M., additional

Published
2020
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33. Additional file 1: of Effect of intraoperative paravertebral or intravenous lidocaine versus control during lung resection surgery on postoperative complications: A randomized controlled trial

Author

Gala, Francisco De La, PiĂąeiro, Patricia, Reyes, Almudena, SimĂłn, Carlos, Vara, Elena, Rancan, Lisa, Huerta, Luis, Gonzalez, Guillermo, Benito, Carmen, MuĂąoz, Marta, Grande, Pilar, Paredes, Sergio, Aznar, Pablo, Perez, Alvaro, Martinez, David, Higuero, Fernando, Sanz, David, Miguel, Juan De, Cruz, Patricia, Olmedilla, Luis, Gil, Elena Lopez, Duque, Patricia, Sanchez-Pedrosa, Guillermo, Valle, Mayte, and Garutti, Ignacio

Abstract

SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (DOC 121 kb)

Published
2019
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34. Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)

Author

Carraminana, Albert, Ferrando, Carlos, Unzueta, M. Carmen, Navarro, Ricard, Suarez-Sipmann, Fernando, Tusman, Gerardo, Garutti, Ignacio, Soro, Marina, Pozo, Natividad, Librero, Julian, Gallego, Lucia, Ramasco, Fernando, Rabanal, Jose M., Rodriguez, Aurelio, Sastre, Jose, Martinez, Jesus, Coves, Silvia, Garcia, Pablo, Aguirre-Puig, Pilar, Yepes, Jose, Lluch, Aitana, Lopez-Herrera, Daniel, Leal, Sonsoles, Vives, Marc, Bellas, Soledad, Socorro, Tania, Trespalacios, Ramon, Salazar, Claudia J., Mugarra, Ana, Cinnella, Gilda, Spadaro, Savino, Futier, Emmanuel, Ferrer, Leopoldo, Cabrera, Maria, Ribeiro, Helder, Celestino, Catarina, Kucur, Evrim, Cervantes, Oriol, Morocho, Diego, Delphy, Dalia, Ramos, Carolina, Villar, Jesus, Belda, Javier, Monedero, Pablo, Martinez, Samira, Comino, Oscar, Coy, Alberto, Armengol, Laura, Pineiro, Patricia, Cruz, Patricia, Duque, Patricia, Andres de la Gala, Francisco, Sanchez, Guillermo, Olmedilla, Luis, de la Fuente, Elena, Erquicia, Inaqui, Reyes, Almudena, Lopez, Elena, Palencia, Maria, Bunger, Beatriz, Ramos, Rafael, Terradillos, Estrella, Almaraz, Carolina, Minguez Lujan, Laura, Lopez, Amparo, Femenia, Francisco, Botella, Santiago, Cimadevilla, Bonifacio, Pascual, Rebeca, Pardo, Sara, Gonzalez, Miren, Lopez, Carlos, Trabanco, Sonia, Zaldibar, Estibaliz, Barolome, Maria J., Pereira, Denis, Otero, Teresa, Blanco, Luisa, Ramon Reparaz, Jose, Ceresuela, Reyes, Castellano, Pedro, Martinez, Pedro, Martinez, Olga, Franco, Juan, Hernandez, Jessica, Pastor, Oriana, Perez, Sara, Solera, Jorge, Guerra, Elisabet, Hussein Dib, Zoraya, Farina, Roberto, Cabrera, Sergio, Pilar Arribas, Maria, Alfonso Sastre, Jose, de Celis, Isabel, Jesus Pascual, Maria, Garcia-Barberena, Belen, Arango, Enrique, Amaya, Oswaldo, Madrid, Guillermo, Triana, Carlos, Pabon, Stefanie, Paola Diaz, Diana, Ortells, Fernando, Perez, Bernardino, Aracil, Ruth, Sanchez, Raquel, Acosta, Jesus, de la Matta, Manuel, Gonzalez, Domingo, Mirabella, Lucia, Rauseo, Michela, Lamanna, Angela, Volta, Carlo Alberto, Ragazzi, Riccardo, Cachapuz, Marta, Correia, Ines, Parera, Ana, Argilaga, Marta, Azparren, Gonzalo, Bausili, Marc, Almajano, Rosa, Aragon, Cristian, Colas, Ana, Cotera, Ignacio, Embun, Raul, Forcada, Pilar, Garces, Cristina, Gil, Fernando, Gracia, Alejandro, Herrero, Miriam, Izquierdo, Blanca, Molinos, Irene, Munoz, Nadia, Puertolas, Maria, Quesada, Natividad, Luis Recuero, Jose, Royo, Inigo, Romero, Blanca, Rubio, Borja, Sandin, Francisco, Alberto Sanjuan-Villarreal, T., Visiedo, Sara, Cordoba, Jose, Pintor, Jestis, Planas, Antonio, Nieves, Jesus M., Garcia, Esther, Vallejo, Carmen, Santidrian, Sheila, Rofso, Paloma, Arocas, Blanca, Gutierrez, Andrea, Charco, Pedro, Jose Parra, Maria, Antonio Carbonell, Jose, Jurado, Ana, Serralta, Ferran, Sancho, Laura, Barcena, Elizabeth, Lascorz, Laura, Belmonte, Luis, Cuervo, Javier, Florea, Raluca, Martinez, Sara, Monleon, Berta, Garcia, Laura, Hurtado, Luis, Pardo, Pablo, Segura, Nasara, Utrera, Esther, Martin, Beatriz, Mellado, Patricia, Juan Arcas, Jose, Martinez, Nuria, Maric, Marina, Enrique Munoz, Luis, Callejas Gonzalez, Raquel, Busquets, Jordi, Homs, Marta, Jimenez, Anabel, Pintanel, Teresa, Martinez, Esther, Moret, Enric, Sercakacilar, Gokhan, Diaz, Maria, Tiago Souteiro, Joao, Benito, Alba, Cebrian, Alba, Mestres, Gerard, Ibrahim Mohamed, Mohamed, Ahmed Yousef, Shahira, Mohamed Osman, Yasser, Moreno, Andres, Tutillo, Andres, Pilco, Henry, Pena, Andrea, Llano, Miguel, Carrillo, Elizabeth, Salazar, Claudia, Dominguez, David, Espinosa, Elena, Carraminana, Albert, Ferrando, Carlos, Unzueta, M. Carmen, Navarro, Ricard, Suarez-Sipmann, Fernando, Tusman, Gerardo, Garutti, Ignacio, Soro, Marina, Pozo, Natividad, Librero, Julian, Gallego, Lucia, Ramasco, Fernando, Rabanal, Jose M., Rodriguez, Aurelio, Sastre, Jose, Martinez, Jesus, Coves, Silvia, Garcia, Pablo, Aguirre-Puig, Pilar, Yepes, Jose, Lluch, Aitana, Lopez-Herrera, Daniel, Leal, Sonsoles, Vives, Marc, Bellas, Soledad, Socorro, Tania, Trespalacios, Ramon, Salazar, Claudia J., Mugarra, Ana, Cinnella, Gilda, Spadaro, Savino, Futier, Emmanuel, Ferrer, Leopoldo, Cabrera, Maria, Ribeiro, Helder, Celestino, Catarina, Kucur, Evrim, Cervantes, Oriol, Morocho, Diego, Delphy, Dalia, Ramos, Carolina, Villar, Jesus, Belda, Javier, Monedero, Pablo, Martinez, Samira, Comino, Oscar, Coy, Alberto, Armengol, Laura, Pineiro, Patricia, Cruz, Patricia, Duque, Patricia, Andres de la Gala, Francisco, Sanchez, Guillermo, Olmedilla, Luis, de la Fuente, Elena, Erquicia, Inaqui, Reyes, Almudena, Lopez, Elena, Palencia, Maria, Bunger, Beatriz, Ramos, Rafael, Terradillos, Estrella, Almaraz, Carolina, Minguez Lujan, Laura, Lopez, Amparo, Femenia, Francisco, Botella, Santiago, Cimadevilla, Bonifacio, Pascual, Rebeca, Pardo, Sara, Gonzalez, Miren, Lopez, Carlos, Trabanco, Sonia, Zaldibar, Estibaliz, Barolome, Maria J., Pereira, Denis, Otero, Teresa, Blanco, Luisa, Ramon Reparaz, Jose, Ceresuela, Reyes, Castellano, Pedro, Martinez, Pedro, Martinez, Olga, Franco, Juan, Hernandez, Jessica, Pastor, Oriana, Perez, Sara, Solera, Jorge, Guerra, Elisabet, Hussein Dib, Zoraya, Farina, Roberto, Cabrera, Sergio, Pilar Arribas, Maria, Alfonso Sastre, Jose, de Celis, Isabel, Jesus Pascual, Maria, Garcia-Barberena, Belen, Arango, Enrique, Amaya, Oswaldo, Madrid, Guillermo, Triana, Carlos, Pabon, Stefanie, Paola Diaz, Diana, Ortells, Fernando, Perez, Bernardino, Aracil, Ruth, Sanchez, Raquel, Acosta, Jesus, de la Matta, Manuel, Gonzalez, Domingo, Mirabella, Lucia, Rauseo, Michela, Lamanna, Angela, Volta, Carlo Alberto, Ragazzi, Riccardo, Cachapuz, Marta, Correia, Ines, Parera, Ana, Argilaga, Marta, Azparren, Gonzalo, Bausili, Marc, Almajano, Rosa, Aragon, Cristian, Colas, Ana, Cotera, Ignacio, Embun, Raul, Forcada, Pilar, Garces, Cristina, Gil, Fernando, Gracia, Alejandro, Herrero, Miriam, Izquierdo, Blanca, Molinos, Irene, Munoz, Nadia, Puertolas, Maria, Quesada, Natividad, Luis Recuero, Jose, Royo, Inigo, Romero, Blanca, Rubio, Borja, Sandin, Francisco, Alberto Sanjuan-Villarreal, T., Visiedo, Sara, Cordoba, Jose, Pintor, Jestis, Planas, Antonio, Nieves, Jesus M., Garcia, Esther, Vallejo, Carmen, Santidrian, Sheila, Rofso, Paloma, Arocas, Blanca, Gutierrez, Andrea, Charco, Pedro, Jose Parra, Maria, Antonio Carbonell, Jose, Jurado, Ana, Serralta, Ferran, Sancho, Laura, Barcena, Elizabeth, Lascorz, Laura, Belmonte, Luis, Cuervo, Javier, Florea, Raluca, Martinez, Sara, Monleon, Berta, Garcia, Laura, Hurtado, Luis, Pardo, Pablo, Segura, Nasara, Utrera, Esther, Martin, Beatriz, Mellado, Patricia, Juan Arcas, Jose, Martinez, Nuria, Maric, Marina, Enrique Munoz, Luis, Callejas Gonzalez, Raquel, Busquets, Jordi, Homs, Marta, Jimenez, Anabel, Pintanel, Teresa, Martinez, Esther, Moret, Enric, Sercakacilar, Gokhan, Diaz, Maria, Tiago Souteiro, Joao, Benito, Alba, Cebrian, Alba, Mestres, Gerard, Ibrahim Mohamed, Mohamed, Ahmed Yousef, Shahira, Mohamed Osman, Yasser, Moreno, Andres, Tutillo, Andres, Pilco, Henry, Pena, Andrea, Llano, Miguel, Carrillo, Elizabeth, Salazar, Claudia, Dominguez, David, and Espinosa, Elena

Abstract

Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.

Published
2019
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35. Protective role of hepatocyte cyclooxygenase-2 expression against liver ischemia-reperfusion injury in mice

Author

Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Ministerio de Economía y Competitividad (España), Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Fuertes-Agudo, Marina, Cucarella, Carme, Flores, Juana María, Vallejo-Cremades, Maria T., Olmedilla, Luis, Pérez Peña, José, Boscá, Lisardo, Casado, Marta, Martín-Sanz, Paloma, Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), European Commission, Ministerio de Economía y Competitividad (España), Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Fuertes-Agudo, Marina, Cucarella, Carme, Flores, Juana María, Vallejo-Cremades, Maria T., Olmedilla, Luis, Pérez Peña, José, Boscá, Lisardo, Casado, Marta, and Martín-Sanz, Paloma

Abstract

Liver ischemia and reperfusion injury (IRI) remains a serious clinical problem affecting liver transplantation outcomes. IRI causes up to 10% of early organ failure and predisposes to chronic rejection. Cyclooxygenase‐2 (COX‐2) is involved in different liver diseases, but the significance of COX‐2 in IRI is a matter of controversy. This study was designed to elucidate the role of COX‐2 induction in hepatocytes against liver IRI. In the present work, hepatocyte‐specific COX‐2 transgenic mice (hCOX‐2‐Tg) and their wild‐type (Wt) littermates were subjected to IRI. hCOX‐2‐Tg mice exhibited lower grades of necrosis and inflammation than Wt mice, in part by reduced hepatic recruitment and infiltration of neutrophils, with a concomitant decrease in serum levels of proinflammatory cytokines. Moreover, hCOX‐2‐Tg mice showed a significant attenuation of the IRI‐induced increase in oxidative stress and hepatic apoptosis, an increase in autophagic flux, and a decrease in endoplasmic reticulum stress compared to Wt mice. Interestingly, ischemic preconditioning of Wt mice resembles the beneficial effects observed in hCOX‐2‐Tg mice against IRI due to a preconditioning‐derived increase in endogenous COX‐2, which is mainly localized in hepatocytes. Furthermore, measurement of prostaglandin E2 (PGE2) levels in plasma from patients who underwent liver transplantation revealed a significantly positive correlation of PGE2 levels and graft function and an inverse correlation with the time of ischemia. Conclusion: These data support the view of a protective effect of hepatic COX‐2 induction and the consequent rise of derived prostaglandins against IRI.

Published
2019

40. Cyclooxygenase-2 expression in hepatocytes protects against hepatic ischemia/reperfusion injury in mice

Author

Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Cucarella, Carme, Fuertes-Agudo, Marina, Flores, Juana María, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, Martín-Sanz, Paloma, Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Casado, Marta, and Casado, Marta [0000-0001-6457-4650]

Abstract

Póster presentado al XLI Congreso de la SEBBM. Santander, 10-13 de septiembre de 2018, Comunicación núm. 6. Liver ischemia and reperfusion injury (IRI) remains a serious clinical problem affecting liver transplantation outcomes. IRI causes up to 10% of early organ failure and predisposes to chronic rejection. Cyclooxygenase-2 (COX-2) is involved in different liver diseases but the significance of COX-2 in liver IRI is a matter of controversy. This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of liver IRI. In the present work hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were subjected to partial IRI and the results show that hCOX-2-Tg exhibited lower grades of necrosis and inflammation than Wt mice in part by reduced recruitment and infiltration of hepatic macrophages and netrophils with a corresponding decrease in serum levels of pro-inflammatory cytokines. Moreover hCOX-2-Tg mice showed a significant attenuation of the IRI-induced increase in oxidative stress and hepatic apoptosis an increase in autophagic flux and a decrease in endoplasmic reticulum (ER) stress comparing with that observed in Wt mice. Preconditioning of Wt mice resembles the beneficial effects of hCOX-2-Tg mice in IRI due to an increase in endogenous COX-2 expression. Furthermore measurement of PGE2 levels in plasma from patients who underwent orthotopic liver transplantation revealed a significantly negative correlation between PGE2 levels and graft function and time of ischemia. Overall the data support the view of the beneficial effects of hepatic COX-2 dependent prostaglandins after liver IRI., This work was supported by i‐COOP2016‐20213 (CSIC) to D.F., P.M.S; SAF2014‐52492 (MINECO, Spain) to L.B.; CIBERcv and CIBERehd (ISCIII, Spain) to L.B., P.M.S and M.C.; SAF2016‐75004‐R (MINECO, Spain) to P.M.S. and M.C. M F‐A. is recipient of FPI fellowship from MINECO (BES‐2017‐081928).

Published
2018

41. Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study

Author

Lominchar, Pablo Lozano, primary, Orue-Echebarria, Maitane Igone, additional, Martín, Lorena, additional, Lisbona, Cristina Julia, additional, Salcedo, María Magdalena, additional, Olmedilla, Luis, additional, Sharma, Hemant, additional, Asencio, Jose Manuel, additional, and López-Baena, José Ángel, additional

Published
2019
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42. Protective Role of Hepatocyte Cyclooxygenase‐2 Expression Against Liver Ischemia–Reperfusion Injury in Mice

Author

Motiño, Omar, primary, Francés, Daniel E., additional, Casanova, Natalia, additional, Fuertes‐Agudo, Marina, additional, Cucarella, Carme, additional, Flores, Juana M., additional, Vallejo‐Cremades, María Teresa, additional, Olmedilla, Luis, additional, Pérez Peña, José, additional, Bañares, Rafael, additional, Boscá, Lisardo, additional, Casado, Marta, additional, and Martín‐Sanz, Paloma, additional

Published
2019
Full Text
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43. Cyclooxygenase-2 expression in hepatocytes protects against hepatic ischemia-reperfusion injury in mice

Author

Ministerio de Economía y Competitividad (España), Casado, Marta [0000-0001-6457-4650], Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Cucarella, Carme, Fuertes-Agudo, Marina, Flores, Juana María, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, Martín-Sanz, Paloma, Ministerio de Economía y Competitividad (España), Casado, Marta [0000-0001-6457-4650], Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Cucarella, Carme, Fuertes-Agudo, Marina, Flores, Juana María, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, and Martín-Sanz, Paloma

Abstract

Comunicación núm. 6. Liver ischemia and reperfusion injury (IRI) remains a serious clinical problem affecting liver transplantation outcomes. IRI causes up to 10% of early organ failure and predisposes to chronic rejection. Cyclooxygenase-2 (COX-2) is involved in different liver diseases but the significance of COX-2 in liver IRI is a matter of controversy. This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of liver IRI. In the present work hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were subjected to partial IRI and the results show that hCOX-2-Tg exhibited lower grades of necrosis and inflammation than Wt mice in part by reduced recruitment and infiltration of hepatic macrophages and netrophils with a corresponding decrease in serum levels of pro-inflammatory cytokines. Moreover hCOX-2-Tg mice showed a significant attenuation of the IRI-induced increase in oxidative stress and hepatic apoptosis an increase in autophagic flux and a decrease in endoplasmic reticulum (ER) stress comparing with that observed in Wt mice. Preconditioning of Wt mice resembles the beneficial effects of hCOX-2-Tg mice in IRI due to an increase in endogenous COX-2 expression. Furthermore measurement of PGE2 levels in plasma from patients who underwent orthotopic liver transplantation revealed a significantly negative correlation between PGE2 levels and graft function and time of ischemia. Overall the data support the view of the beneficial effects of hepatic COX-2 dependent prostaglandins after liver IRI.

Published
2018

44. Cyclooxygenase-2 expression in hepatocytes protects against hepatic ischemia/reperfusion injury in mice

Author

Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Cucarella, Carme, Fuertes-Agudo, Marina, Flores, Juana María, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, Martín-Sanz, Paloma, Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Motiño, Omar, Francés, Daniel E., Casanova, Natalia, Cucarella, Carme, Fuertes-Agudo, Marina, Flores, Juana María, Olmedilla, Luis, Pérez Peña, José, Bañares, Rafael, Boscá, Lisardo, Casado, Marta, and Martín-Sanz, Paloma

Abstract

Liver ischemia and reperfusion injury (IRI) remains a serious clinical problem affecting liver transplantation outcomes. IRI causes up to 10% of early organ failure and predisposes to chronic rejection. Cyclooxygenase-2 (COX-2) is involved in different liver diseases but the significance of COX-2 in liver IRI is a matter of controversy. This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of liver IRI. In the present work hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were subjected to partial IRI and the results show that hCOX-2-Tg exhibited lower grades of necrosis and inflammation than Wt mice in part by reduced recruitment and infiltration of hepatic macrophages and netrophils with a corresponding decrease in serum levels of pro-inflammatory cytokines. Moreover hCOX-2-Tg mice showed a significant attenuation of the IRI-induced increase in oxidative stress and hepatic apoptosis an increase in autophagic flux and a decrease in endoplasmic reticulum (ER) stress comparing with that observed in Wt mice. Preconditioning of Wt mice resembles the beneficial effects of hCOX-2-Tg mice in IRI due to an increase in endogenous COX-2 expression. Furthermore measurement of PGE2 levels in plasma from patients who underwent orthotopic liver transplantation revealed a significantly negative correlation between PGE2 levels and graft function and time of ischemia. Overall the data support the view of the beneficial effects of hepatic COX-2 dependent prostaglandins after liver IRI.

Published
2018

46. Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial

Author

Ferrando, Carlos, primary, Soro, Marina, additional, Unzueta, Carmen, additional, Suarez-Sipmann, Fernando, additional, Canet, Jaume, additional, Librero, Julián, additional, Pozo, Natividad, additional, Peiró, Salvador, additional, Llombart, Alicia, additional, León, Irene, additional, India, Inmaculada, additional, Aldecoa, Cesar, additional, Díaz-Cambronero, Oscar, additional, Pestaña, David, additional, Redondo, Francisco J, additional, Garutti, Ignacio, additional, Balust, Jaume, additional, García, Jose I, additional, Ibáñez, Maite, additional, Granell, Manuel, additional, Rodríguez, Aurelio, additional, Gallego, Lucía, additional, de la Matta, Manuel, additional, Gonzalez, Rafael, additional, Brunelli, Andrea, additional, García, Javier, additional, Rovira, Lucas, additional, Barrios, Francisco, additional, Torres, Vicente, additional, Hernández, Samuel, additional, Gracia, Estefanía, additional, Giné, Marta, additional, García, María, additional, García, Nuria, additional, Miguel, Lisset, additional, Sánchez, Sergio, additional, Piñeiro, Patricia, additional, Pujol, Roger, additional, García-del-Valle, Santiago, additional, Valdivia, José, additional, Hernández, María J, additional, Padrón, Oto, additional, Colás, Ana, additional, Puig, Jaume, additional, Azparren, Gonzalo, additional, Tusman, Gerardo, additional, Villar, Jesús, additional, Belda, Javier, additional, Acosta, Jesús, additional, Aguilar, Gerardo, additional, Alberola, María José, additional, Alcón, Amalia, additional, Alonso, Jose M., additional, Alonso, María Dolores, additional, Anaya, Rafael, additional, Argente, María Pilar, additional, Agilaga, Marta, additional, Arocas, Blanca, additional, Asensio, Ana, additional, Ayas, Begoña, additional, Ayuso, Mercedes, additional, Balandrón, Victor, additional, Barrio, María, additional, Bejarano, Natalia, additional, Benítez, Inmaculada, additional, Cabrera, Sergio, additional, Carbonell, Jose A., additional, Carramiñana, Albert, additional, Carrizo, Juan, additional, Cegarra, Virginia, additional, Chamorro, Estefanía, additional, Charco, Pedro, additional, Cruz, Patricia, additional, Daviu, Francisco, additional, De Fez, Mario, additional, De Miguel, Ángeles, additional, Del Río, Elena, additional, Delgado, Carlos, additional, Díaz, Ruben, additional, Díaz, Susana, additional, Díez, Fernando, additional, Dosdá, Rosa, additional, Duca, Alejandro, additional, Etulain, Ma Justina, additional, Fernández, Carmen, additional, Franco, Tania, additional, Fuentes, Isabel, additional, Gallego, Clara, additional, Gallego-Casilda, Alberto, additional, Galve, Ana Isabel, additional, Garcés, Cristina, additional, García, Mercedes, additional, García, Pablo, additional, Garrigues, Beatriz, additional, Gilabert, Vicente, additional, González, Domingo, additional, Gutiérrez, Andrea, additional, Hernández, Inmaculada, additional, Izquierdo, Ana, additional, Jurado, Ana, additional, Katime, Antonio, additional, Llamazares, Eduardo, additional, Lardies, Rosa, additional, Lisbona, Cristina, additional, López-Herrera, Daniel, additional, López, Ramiro, additional, Lozano, Angels, additional, Lozano, Elena, additional, Marcos, Jose Miguel, additional, Martin, Silvia, additional, Martínez, Nilda, additional, Martínez, Rocío, additional, Martínez-Pallí, Graciella, additional, Mazzinari, Guido, additional, Miñana, Amanda, additional, Moral, Victoria, additional, Moreno, Tania, additional, Mugarra, Ana, additional, Muñoz, Lorena, additional, Navarro, Jose, additional, Olmedilla, Luis, additional, Olmedo, Jonathan, additional, Ojeda, Nazario, additional, Parera, Ana, additional, Parra, María, additional, Parrilla, Cristina, additional, Pastor, Ernesto, additional, Peña, Natalia, additional, Pérez, Ana María, additional, Pérez, Jose María, additional, Piqueras, Laura, additional, Rico-Feijoo, Jesús, additional, Rodríguez, Rayco, additional, Román, Javier Ignacio, additional, Romero, Antonio, additional, Romero, Carolina, additional, Romero, Esther, additional, Ruiz, Isabel, additional, Sánchez, Ester, additional, Sandín, Francisco, additional, Serralta, Ferran, additional, Socorro, Tania, additional, Soriano, Laura, additional, Tisner, Manuel, additional, Valencia, Lucia, additional, Valls, Paola, additional, Vaquero, Laura, additional, Varón, Viviana, additional, Vila, María, additional, Villazala, Rubén, additional, Villena, Abigail, additional, and Zapatero, Sara, additional

Published
2018
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48. Early Measurement of Indocyanine Green Clearance Accurately Predicts Short-Term Outcomes After Liver Transplantation

Author

Olmedilla, Luis, primary, Lisbona, Cristina J., additional, Pérez-Peña, José M., additional, López-Baena, José A., additional, Garutti, Ignacio, additional, Salcedo, Magdalena, additional, Sanz, Javier, additional, Tisner, Manuel, additional, Asencio, José M., additional, Fernández-Quero, Lorenzo, additional, and Bañares, Rafael, additional

Published
2016
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49. Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery

Author

de la Gala, Francisco, primary, Piñeiro, Patricia, additional, Garutti, Ignacio, additional, Reyes, Almudena, additional, Olmedilla, Luis, additional, Cruz, Patricia, additional, Duque, Patricia, additional, Casanova, Javier, additional, Rancan, Lisa, additional, Benito, Pilar, additional, and Vara, Elena, additional

Published
2015
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50. Extravascular Lung Water and Pulmonary Vascular Permeability Index Measured at the End of Surgery Are Independent Predictors of Prolonged Mechanical Ventilation in Patients Undergoing Liver Transplantation

Author

Garutti, Ignacio, primary, Sanz, Javier, additional, Olmedilla, Luis, additional, Tranche, Itziar, additional, Vilchez, Almudena, additional, Fernandez-Quero, Lorenzo, additional, Bañares, Rafael, additional, and Perez-Peña, Jose María, additional

Published
2015
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