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151 results on '"Olivola, Enrica"'

1. Multidisciplinary care use in neurodegenerative complex diseases: The example of progressive supranuclear palsy and advanced Parkinson's disease in real-life

Author

Serio, Marina, Zibetti, Maurizio, Bissacco, Jacopo, Satolli, Sara, Sambati, Luisa, Bacchin, Ruggero, Longo, Chiara, Marchese, Roberta, Panetta, Salvatore, Magistrelli, Luca, Contaldi, Elena, Moschella, Vincenzo, Altavista, Maria Concetta, Costanzo, Matteo, Fabbrini, Giovanni, Olivola, Enrica, Modugno, Nicola, Cincotta, Massimo, Piccininni, Maristella, Capecci, Marianna, Baldini, Nicolò, Ciammola, Andrea, Ticozzi, Nicola, Raffaella, Di Giacopo, De Togni, Laura, Sala, Francesca, Nicoletti, Alessandra, Cicero, Edoardo, Ceravolo, Roberto, Del Prete, Eleonora, Fabbri, Margherita, Ledda, Claudia, Schirinzi, Tommaso, Artusi, Carlo Alberto, Avallone, Anna Rosa, Zenuni, Henri, De Micco, Rosa, Aloisio, Simone, Cani, Ilaria, Malaguti, Maria Chiara, Di Biasio, Francesca, Calandra-Buonaura, Giovanna, Stefani, Alessandro, Lopiano, Leonardo, Barone, Paolo, and Picillo, Marina

Published
2024
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3. Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?

Author

Ercoli, Tommaso, Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Spano, Giorgio, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Stocchi, Fabrizio, and Defazio, Giovanni

Published
2022
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4. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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5. Functional motor phenotypes: to lump or to split?

Author

Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Magro, Giuseppe, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Zanolin, Elisabetta, Albanese, Alberto, Ferrazzano, Gina, De Micco, Rosa, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Ercoli, Tommaso, Morgante, Francesca, and Erro, Roberto

Published
2021
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7. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, Albanese, Alberto (ORCID:0000-0002-5864-0006), Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

BackgroundFunctional motor disorders (FMD) are a frequent neurological condition affecting patients with movement disorders. Commonly described in younger adults, their manifestation can be also associated to an elderly onset.ObjectiveTo assess the prevalence and describe the clinical manifestations of FMD with elderly and younger onset and their relationship with demographical and clinical variables.MethodsWe recruited patients with a "clinically definite" diagnosis of FMD from the Italian Registry of FMD. Patients underwent extensive clinical assessments. For elderly onset, we set a chronological cut-off at 65 years or older according to WHO definition. Multivariate regression models were implemented to estimate adjusted odds ratio of elderly FMD onset related to clinical characteristics.ResultsAmong the 410 patients, 34 (8.2%) experienced elderly-onset FMD, with a mean age at onset of 70.9 years. The most common phenotype was tremor (47.1%), followed by gait disorders, weakness, and dystonia (29.4%, 23.5%, 14.7%, respectively). Eleven elderly patients had a combined phenomenology: 9 exhibited two phenotypes, 2 had three phenotypes. Weakness was isolated in 3/8 patients and combined with another phenotype in 5/8, manifesting as paraplegia (n = 4); upper limb diplegia (n = 2), hemiparesis/hemiplegia (n = 1), and tetraparesis/tetraplegia (n= 1). Non-motor and other functional neurological disorders occurred more frequently in the younger group (89.1%) than the elderly (73.5%). Neurological and non-neurological comorbidities were more prevalent in the elderly group (82.4%) as opposed to the younger (32.7%). In a multivariate regression analysis, elderly-onset FMD was significantly associated with neurological comorbidities, including parkinsonism (OR 6.73) and cerebrovascular diseases (OR 5.48).ConclusionsThese results highlight the importance of achieving an accurate diagnosis of FMD in the elderly, as it is crucial for effectively managing FMD symptoms and addressi

Published
2024

8. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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9. Levodopa–carbidopa intrajejunal infusion in Parkinson’s disease: untangling the role of age

Author

Morgante, Francesca, Oppo, Valentina, Fabbri, Margherita, Olivola, Enrica, Sorbera, Chiara, De Micco, Rosa, Ielo, Giovanna Chiara, Colucci, Fabiana, Bonvegna, Salvatore, Novelli, Alessio, Modugno, Nicola, Sensi, Mariachiara, Zibetti, Maurizio, Lopiano, Leonardo, Tessitore, Alessandro, Pilleri, Manuela, Cilia, Roberto, Elia, Antonio E., Eleopra, Roberto, Ricciardi, Lucia, and Cossu, Giovanni

Published
2021
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11. Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.

Author

Erro, Roberto, Lazzeri, Giulia, Terranova, Carmen, Paparella, Giulia, Gigante, Angelo Fabio, De Micco, Rosa, Magistrelli, Luca, Di Biasio, Francesca, Valentino, Francesca, Moschella, Vincenzo, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Malaguti, Maria Chiara, Ceravolo, Roberto, Dallocchio, Carlo, Spagnolo, Francesca, Nicoletti, Alessandra, De Rosa, Anna, and Di Giacopo, Raffaella

Subjects
ESSENTIAL tremor, TREMOR, DYSTONIA, SEX distribution, REGRESSION analysis, QUALITY of life
Abstract

Background: Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non‐parkinsonian tremors is relatively high. Objectives: To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD). Methods: We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life. Results: Three‐hundred‐eighty‐three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task‐specificity, and position‐dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor. Conclusions: Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra‐group heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, primary, Petracca, Martina, additional, Di Tella, Sonia, additional, Marcuzzo, Enrico, additional, Erro, Roberto, additional, Cuoco, Sofia, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Romito, Luigi Michele, additional, Eleopra, Roberto, additional, Zappia, Mario, additional, Nicoletti, Alessandra, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Laterza, Vincenzo, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Bonanni, Laura, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, Tessitore, Alessandro, additional, Lopiano, Leonardo, additional, Calandra‐Buonaura, Giovanna, additional, Morgante, Francesca, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Tesolin, Lucia, additional, Teatini, Francesco, additional, Camozzi, Serena, additional, Ercoli, Tommaso, additional, Stocchi, Fabrizio, additional, Coletti Moja, Mario, additional, Defazio, Giovanni, additional, and Tinazzi, Michele, additional

Published
2023
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15. Contributors

Author

Abboud, Hesham, primary, Abdelkader, Noha F., additional, Abellanas, Miguel A., additional, Adams, Warwick R., additional, Airavaara, Mikko, additional, Al-Busaidi, Ibrahim S., additional, Alamri, Yassar, additional, Alberico, Stephanie L., additional, Alexiou, Athanasios, additional, Almeida, Lorena Rosa S., additional, Anderton, Ryan S., additional, Antipova, Veronica, additional, Aragona, Emanuela, additional, Arrigo, Alessandro, additional, Ashraf, Ghulam Md, additional, Auffret, Manon, additional, Aymerich, Maria S., additional, Bakeberg, Megan, additional, Barnes, Graham R., additional, Belbasis, Lazaros, additional, Bellou, Vanesa, additional, Benedetti, Fabrizio, additional, Benson, Patrick, additional, Bergantin, Leandro Bueno, additional, Bhidayasiri, Roongroj, additional, Bortolanza, Mariza, additional, Byrnes, Michelle, additional, Calamuneri, Alessandro, additional, Caricati-Neto, Afonso, additional, Carlino, Elisa, additional, Chaudhary, Sapana Sameer, additional, Chaudhary, Sameer, additional, Chmielarz, Piotr, additional, Chuproski, Ana Paula, additional, Del-Bel, Elaine, additional, De Risi, Marco, additional, Devedjian, J.C., additional, Devos, D., additional, Di Gennaro, Giancarlo, additional, Domanskyi, Andrii, additional, Dominico, Patrícia, additional, Drapier, Sophie, additional, Duce, J.A., additional, Dutta, Aloke K., additional, Eidelberg, David, additional, Evangelou, Evangelos, additional, Fagotti, Juliane, additional, Farotti, Lucia, additional, Fisichella, M., additional, Forjaz, Maria João, additional, Frisaldi, Elisa, additional, Fuermaier, Anselm B.M., additional, Fukushima, Kikuro, additional, Fukushima, Junko, additional, Gaeta, Michele, additional, Gordon, Luke, additional, Hawlitschka, Alexander, additional, Holzmann, Carsten, additional, Jansen, Josephien, additional, Januário, Cristina, additional, Jesus-Ribeiro, Joana, additional, Johnstone, Daniel M., additional, Koerts, Janneke, additional, Konovalova, Julia, additional, Kurth, Jens, additional, Lachaud, C., additional, Laloux, C., additional, Lanotte, Michele, additional, LeWitt, Peter A., additional, Lima, Marcelo M.S., additional, Lindner, Tobias, additional, Loewenbrück, K.F., additional, Lopiano, Leonardo, additional, Luo, Dan, additional, Mann, Teresa, additional, Mao, Peizhong, additional, Mao, Yifan, additional, Martinez–Martin, Pablo, additional, Mastaglia, Frank L., additional, Mizutani, Yasuaki, additional, Modugno, Nicola, additional, Moreau, C., additional, Mormina, Enricomaria, additional, Müller, Thomas, additional, Mutoh, Tatsuro, additional, Nagao, Kanae, additional, Narayanan, Nandakumar S., additional, Nascimento, Glauce Crivelaro, additional, Natesan, Saieswari, additional, Neilson, Lee, additional, Niimi, Yoshiki, additional, Olivola, Enrica, additional, Pan-Montojo, F., additional, Panhelainen, Anne, additional, Paolini Paoletti, Federico, additional, Pardeshi, Tanvee, additional, Parnetti, Lucilla, additional, Paul, Serene S., additional, Perovnik, Matej, additional, Petrucco, Claudia, additional, Piedimonte, Alessandro, additional, Rawat, Sakshi, additional, Reichmann, H., additional, Reith, Maarten, additional, Riley, Maddeson, additional, Rodríguez-Blázquez, Carmen, additional, Rožanković, Petra Bago, additional, Rus, Tomaž, additional, Sakakibara, Ryuji, additional, Santos-Lobato, Bruno L., additional, Scorza, Fúlvio Alexandre, additional, Stone, Jonathan, additional, Tang, Chris C., additional, Targa, Adriano D.S., additional, Tateno, Fuyuki, additional, Tomše, Petra, additional, Trošt, Maja, additional, Tsiang, John T.H., additional, Tucha, Lara, additional, Tucha, Oliver, additional, Uchiyama, Tomoyuki, additional, Valenca, Guilherme T., additional, Vérin, Marc, additional, Vieira, Daniela, additional, Willis, Gregory L., additional, Witt, Martin, additional, Woo, Benjamin K.P., additional, Wree, Andreas, additional, Yamamoto, Tatsuya, additional, Zande, Jonathan, additional, and Zibetti, Maurizio, additional

Published
2020
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16. Validation of the Italian version of the PSP Quality of Life questionnaire

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B., Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, and Barone, Paolo

Published
2019
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17. Validation of the Italian version of carers’ quality-of-life questionnaire for parkinsonism (PQoL Carer) in progressive supranuclear palsy

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruno, Antonino, Bruschi, Fabio, Cappiello, Arianna, De Micco, Rosa, De Rosa, Anna, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Lopiano, Leonardo, Marchese, Roberta, Mercuri, Nicola B, Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, and Barone, Paolo

Published
2019
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22. Levodopa Equivalent Dose of Safinamide: A Multicenter, Longitudinal, Case–Control Study

Author

Cilia, Roberto, primary, Cereda, Emanuele, additional, Piatti, Marco, additional, Pilotto, Andrea, additional, Magistrelli, Luca, additional, Golfrè Andreasi, Nico, additional, Bonvegna, Salvatore, additional, Contaldi, Elena, additional, Mancini, Francesca, additional, Imbalzano, Gabriele, additional, De Micco, Rosa, additional, Colucci, Fabiana, additional, Braccia, Arianna, additional, Bellini, Gabriele, additional, Brovelli, Francesco, additional, Zangaglia, Roberta, additional, Lazzeri, Giulia, additional, Russillo, Maria Claudia, additional, Olivola, Enrica, additional, Sorbera, Chiara, additional, Cereda, Viviana, additional, Pinto, Patrizia, additional, Sucapane, Patrizia, additional, Gelosa, Giorgio, additional, Meloni, Mario, additional, Pistoia, Francesca, additional, Sessa, Maria, additional, Canesi, Margherita, additional, Modugno, Nicola, additional, Pacchetti, Claudio, additional, Brighina, Laura, additional, Pellecchia, Maria Teresa, additional, Ceravolo, Roberto, additional, Sensi, Mariachiara, additional, Zibetti, Maurizio, additional, Comi, Cristoforo, additional, Padovani, Alessandro, additional, Zecchinelli, Anna L., additional, Di Fonzo, Alessio, additional, Tessitore, Alessandro, additional, Morgante, Francesca, additional, and Eleopra, Roberto, additional

Published
2023
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23. Data-driven clustering of combined Functional Motor Disorders based on the Italian registry

Author

Mostile, Giovanni, primary, Geroin, Christian, additional, Erro, Roberto, additional, Luca, Antonina, additional, Marcuzzo, Enrico, additional, Barone, Paolo, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Romito, Luigi Michele, additional, Eleopra, Roberto, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Bruno, Pietro Antonio, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Bonanni, Laura, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, De Micco, Rosa, additional, Zibetti, Maurizio, additional, Calandra-Buonaura, Giovanna, additional, Petracca, Martina, additional, Morgante, Francesca, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Stocchi, Fabrizio, additional, Coletti Moja, Mario, additional, Di Vico, Ilaria Antonella, additional, Tesolin, Lucia, additional, De Bertoldi, Francesca, additional, Ercoli, Tommaso, additional, Defazio, Giovanni, additional, Zappia, Mario, additional, Nicoletti, Alessandra, additional, and Tinazzi, Michele, additional

Published
2022
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25. Clinical correlates of "pure" essential tremor: the TITAN study.

Author

Erro, Roberto, Lazzeri, Giulia, Gigante, Angelo Fabio, Pilotto, Andrea, Magistrelli, Luca, Bologna, Matteo, Terranova, Carmen, Olivola, Enrica, Dallocchio, Carlo, Moschella, Vincenzo, Valentino, Francesca, Di Biasio, Francesca, Nicoletti, Alessandra, De Micco, Rosa, Brusa, Livia, Sorrentino, Cristiano, Matinella, Angela, Bertino, Salvatore, Paparella, Giulia, and Modugno, Nicola

Subjects
TREMOR, ESSENTIAL tremor, AGE of onset, DISEASE duration, AGE distribution, SEX distribution, DATABASES
Abstract

Background: To date, there are no large studies delineating the clinical correlates of "pure" essential tremor (ET) according to its new definition. Methods: From the ITAlian tremor Network (TITAN) database, we extracted data from patients with a diagnosis of "pure" ET and excluded those with other tremor classifications, including ET-plus, focal, and task-specific tremor, which were formerly considered parts of the ET spectrum. Results: Out of 653 subjects recruited in the TITAN study by January 2022, the data of 208 (31.8%) "pure" ET patients (86M/122F) were analyzed. The distribution of age at onset was found to be bimodal. The proportion of familial cases by the age-at-onset class of 20 years showed significant differences, with sporadic cases representing the large majority of the class with an age at onset above 60 years. Patients with a positive family history of tremor had a younger onset and were more likely to have leg involvement than sporadic patients despite a similar disease duration. Early-onset and late-onset cases were different in terms of tremor distribution at onset and tremor severity, likely as a function of longer disease duration, yet without differences in terms of quality of life, which suggests a relatively benign progression. Treatment patterns and outcomes revealed that up to 40% of the sample was unsatisfied with the current pharmacological options. Discussion: The findings reported in the study provide new insights, especially with regard to a possible inversed sex distribution, and to the genetic backgrounds of "pure" ET, given that familial cases were evenly distributed across age-at-onset classes of 20 years. Deep clinical profiling of "pure" ET, for instance, according to age at onset, might increase the clinical value of this syndrome in identifying pathogenetic hypotheses and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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26. A Bayesian approach to Essential Tremor plus: A preliminary analysis of the TITAN cohort

Author

Angela Matinella, Sciarretta, Massimo, Perillo, Sandra, Giglio, Augusta, Raglione, Laura Maria, Terranova, Carmen, Altavista, Maria Concetta, Spagnolo, Francesca, Pecoraro, Pasquale Maria, Malaguti, Maria Chiara, Misceo, Salvatore, Zoccolella, Stefano, Marchese, Roberta, Benzi, Tiziana, Gallo, Silvia, Paparella, Giulia, Angelini, Luca, Lazzeri, Giulia, Franco, Giulia, Di Giacopo, Raffaella, De Micco, Rosa, Aramini, Simone, Ceravolo, Roberto, Mostile, Giovanni, Morgante, Francesca, Brusa, Livia, Erro, Roberto, Pilotto, Andrea, Magistrelli, Luca, Olivola, Enrica, Nicoletti, Alessandra, Di Fonzo, Alessio, Dallocchio, Carlo, Di Biasio, Francesca, Bologna, Matteo, Tessitore, Alessandro, De Rosa, Anna, Gigante, Angelo Fabio, Esposito, Marcello, Moschella, Vincenzo, di Biase, Lazzaro, Valentino, Francesca, Russo, Maria, Contaldi, Elena, Modugno, Nicola, Padovani, Alessandro, and Barone, Paolo

Published
2022
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27. Functional gait disorders: Demographic and clinical correlations

Author

Tinazzi, Michele, Pilotto, Andrea, Morgante, Francesca, Marcuzzo, Enrico, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Magro, Giuseppe, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Zanolin, Elisabetta, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Defazio, Giovanni, Ercoli, Tommaso, Stocchi, Fabrizio, Erro, Roberto, Zappia, Mario, and Geroin, Christian

Published
2021
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33. Functional motor disorders associated with other neurological diseases: Beyond the boundaries of “organic” neurology

Author

Tinazzi, Michele, primary, Geroin, Christian, additional, Erro, Roberto, additional, Marcuzzo, Enrico, additional, Cuoco, Sofia, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Romito, Luigi Michele, additional, Eleopra, Roberto, additional, Zappia, Mario, additional, Nicoletti, Alessandra, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Pascarella, Angelo, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Bonanni, Laura, additional, Antelmi, Elena, additional, Zanolin, Elisabetta, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, Micco, Rosa, additional, Lopiano, Leonardo, additional, Calandra‐Buonaura, Giovanna, additional, Petracca, Martina, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Stocchi, Fabrizio, additional, Coletti Moja, Mario, additional, Antonini, Angelo, additional, Ercoli, Tommaso, additional, and Morgante, Francesca, additional

Published
2021
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34. Levodopa–carbidopa intrajejunal infusion in Parkinson’s disease: untangling the role of age

Author

Morgante, Francesca, primary, Oppo, Valentina, additional, Fabbri, Margherita, additional, Olivola, Enrica, additional, Sorbera, Chiara, additional, De Micco, Rosa, additional, Ielo, Giovanna Chiara, additional, Colucci, Fabiana, additional, Bonvegna, Salvatore, additional, Novelli, Alessio, additional, Modugno, Nicola, additional, Sensi, Mariachiara, additional, Zibetti, Maurizio, additional, Lopiano, Leonardo, additional, Tessitore, Alessandro, additional, Pilleri, Manuela, additional, Cilia, Roberto, additional, Elia, Antonio E., additional, Eleopra, Roberto, additional, Ricciardi, Lucia, additional, and Cossu, Giovanni, additional

Published
2020
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35. Clinical Correlates of Functional Motor Disorders: An Italian Multicenter Study

Author

Tinazzi, Michele, primary, Morgante, Francesca, additional, Marcuzzo, Enrico, additional, Erro, Roberto, additional, Barone, Paolo, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Romito, Luigi M., additional, Eleopra, Roberto, additional, Zappia, Mario, additional, Nicoletti, Alessandra, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Pascarella, Angelo, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Di Stefano, Vincenzo, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, Tessitore, Alessandro, additional, Zibetti, Maurizio, additional, Calandra‐Buonaura, Giovanna, additional, Petracca, Martina, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Stocchi, Fabrizio, additional, Coletti Moja, Mario, additional, Antonini, Angelo, additional, Defazio, Giovanni, additional, and Geroin, Christian, additional

Published
2020
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39. Progressive Supranuclear Palsy Quality of Life Scale--Italian Version

Author

Picillo, Marina, primary, Cuoco, Sofia, additional, Amboni, Marianna, additional, Bonifacio, Francesco Paolo, additional, Bruschi, Fabio, additional, Carotenuto, Immacolata, additional, De Micco, Rosa, additional, De Rosa, Anna, additional, Del Prete, Eleonora, additional, Di Biasio, Francesca, additional, Elifani, Francesca, additional, Erro, Roberto, additional, Fabbri, Margherita, additional, Falla, Marika, additional, Franco, Giulia, additional, Frosini, Daniela, additional, Galantucci, Sebastiano, additional, Lazzeri, Giulia, additional, Magistrelli, Luca, additional, Malaguti, Maria Chiara, additional, Milner, Anna Vera, additional, Minafra, Brigida, additional, Olivola, Enrica, additional, Pilotto, Andrea, additional, Rascunà, Cristina, additional, Rizzetti, Maria Cristina, additional, Schirinzi, Tommaso, additional, Borroni, Barbara, additional, Ceravolo, Roberto, additional, Di Fonzo, Alessio, additional, Marchese, Roberta, additional, Mercuri, Nicola B., additional, Modugno, Nicola, additional, Nicoletti, Alessandra, additional, Padovani, Alessandro, additional, Santangelo, Gabriella, additional, Stefani, Alessandro, additional, Tessitore, Alessandro, additional, Volontè, Maria Antonietta, additional, Zangaglia, Roberta, additional, Zappia, Mario, additional, Zibetti, Maurizio, additional, and Barone, Paolo, additional

Published
2019
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40. Parkinsonism Carers Quality of Life--Italian Version

Author

Piccilo, Marina, primary, Cuoco, Sofia, additional, Amboni, Marianna, additional, Bonifacio, Francesco Paolo, additional, Bruno, Antonino, additional, Bruschi, Fabio, additional, Cappiello, Arianna, additional, De Micco, Rosa, additional, De Rosa, Anna, additional, Di Biasio, Francesca, additional, Elifani, Francesca, additional, Erro, Roberto, additional, Fabbri, Margherita, additional, Falla, Marika, additional, Franco, Giulia, additional, Frosini, Daniela, additional, Galantucci, Sebastiano, additional, Lazzeri, Giulia, additional, Magistrelli, Luca, additional, Malaguti, Maria Chiara, additional, Milner, Anna Vera, additional, Minafra, Brigida, additional, Olivola, Enrica, additional, Pilotto, Andrea, additional, Rascunà, Cristina, additional, Rizzetti, Maria Cristina, additional, Schirinzi, Tommaso, additional, Borroni, Barbara, additional, Ceravolo, Roberto, additional, Di Fonzo, Alessio, additional, Lopiano, Leonardo, additional, Marchese, Roberta, additional, Mercuri, Nicola B., additional, Modugno, Nicola, additional, Nicoletti, Alessandra, additional, Padovani, Alessandro, additional, Santangelo, Gabriella, additional, Stefani, Alessandro, additional, Tessitore, Alessandro, additional, Volontè, Maria Antonietta, additional, Zangaglia, Roberta, additional, Zappia, Mario, additional, and Barone, Paolo, additional

Published
2019
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41. Effects of Prismatic Lenses on Lateral Axial Dystonia in Parkinson's Disease: A Pilot Study.

Author

MEGLIO, MICHELE, OLIVOLA, ENRICA, SANTILLI, MARCO, LENA, FRANCESCO, CENTONZE, DIEGO, BOLOGNA, MATTEO, and MODUGNO, NICOLA

Subjects
BACKACHE prevention, PILOT projects, PISA syndrome, PAIN measurement, TREATMENT effectiveness, SEVERITY of illness index, PRE-tests & post-tests, PARKINSON'S disease, DISEASE duration, DESCRIPTIVE statistics, LENSES, DISEASE complications, EVALUATION
Abstract

OBJECTIVE: In Parkinson's disease (PD), postural abnormalities such as lateral axial dystonia (LAD) are relatively common. Evidence suggests that both peripheral and central mechanisms contribute to these postural abnormalities. We previously reported an improvement in LAD following the use of prisms in two PD patients. Here, we further investigate the eff ects of prismatic lenses in a case series of nine patients with PD and LAD. METHODS: Nine patients underwent an orthoptic evaluation and were provided with prismatic lenses. Patients were evaluated at baseline and after one and three months of permanent prismatic lens use and again re-evaluated one month after the discontinuation of prismatic lens use. RESULTS: We found a linear relationship between disease duration and LAD severity. Compared to basal measurements, we observed a slight improvement in LAD. Furthermore, we found a significant reduction in self-perceived back pain due to the use of prismatic lenses. There was no significant association between the individual effects of prismatic lenses in patients with PD and their baseline LAD or other clinical and demographic features (all P>0.05). CONCLUSION: The present pilot study provides novel data on the possible effectiveness of prismatic lenses for LAD treatment in PD patients. [ABSTRACT FROM AUTHOR]

Published
2021

42. Early-stage Parkinson's patients show selective impairment in reactive but not proactive inhibition.

Author

Di Caprio, Veronica, Modugno, Nicola, Mancini, Christian, Olivola, Enrica, and Mirabella, Giovanni

Abstract

Background: It is well known that a deficit in inhibitory control is a hallmark of Parkinson's disease (PD). However, inhibition is not a unitary construct, and it is unclear whether patients in the early stage of the disease (Hoehn and Yahr stage 1) exhibit a deficit in outright stopping (reactive inhibition), a deficit in the ability to shape their response strategies according to the context (proactive inhibition), or both.Objective: We assessed whether PD patients at Hoehn and Yahr stage 1 show a global or selective impairment in inhibitory control. As it has been suggested that inhibition relies upon a right-lateralized pathway, we tested whether left-dominant PD patients suffered from a more severe deficit in this executive function than right-dominant PD patients.Methods: Via a reaching stop-signal task, we assessed both proactive and reactive inhibition in 17 left-dominant PD and 17 right-dominant PD patients and in 24 age-matched participants.Results: We found that reactive inhibition was more impaired in PD patients than in healthy participants. However, proactive inhibition was not affected. Furthermore, we found no differences between left-dominant PD and right-dominant PD patients.Conclusions: For the first time, we found evidence for a deficit of reactive inhibition in the early-stage PD patients in the absence of evidence for deficits in proactive inhibition. These findings have clinical relevance as they provide critical insights on the time course of the disease. In addition, we confirmed, on a population of PD patients at Hoehn and Yahr stage 1, previous results showing that the onset of the disease does not affect inhibition. © 2019 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2020
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44. Low Serum 25(OH)D Levels in Parkinson ’s Disease; a Non Specific Marker of Neurodegeneration?

Author

Olivola Enrica, Conti Marco, Stefani Aless, Liguori Claudio, Pierantozzi Mariangela, and Cerroni Rocco

Subjects
medicine.medical_specialty, Mini–Mental State Examination, Parkinson's disease, medicine.diagnostic_test, business.industry, Neurodegeneration, medicine.disease, Gastroenterology, Internal medicine, Cohort, Vitamin D and neurology, medicine, Dementia, Settore MED/26 - Neurologia, Amyotrophic lateral sclerosis, business, Pathological, Neuroscience
Abstract

Objective: Several investigations have recently inferred that a low serum vitamin D concentration may contribute to cognitive impairment in the elderly. Here, we assessed whether in a cohort of Parkinson’s disease (PD) patients attributable to any disease stage a deficit in serum 25-hydroxyvitamin D (25(OH) D) levels occurred as previously proposed and, more importantly, if it is correlated with cognitive impairment or disease duration. Methods: Our PD group (n=54) was compared to an age-matched control group (n= 30), but also to patients afflicted by Alzheimer’s disease (AD) (n= 17) and motor neuron disease (amyotrophic lateral sclerosis - ALS) (n=19). Results: Serum 25(OH)D levels > 30 ng/ml was found in 37% of PD patients (versus 76% in controls); in 34 out of 54 PD patients low 25(OH)D levels occurred (28,73 ± 20,22 ng/ml vs 44,52 ± 18,48 ng/ml in control group); however, no correlation with mini mental state examination (MMSE) or disease progression emerged in PD patients. AD cohort was characterized by a significantly lower vitamin D concentration (half manifesting severe deficiency below 10 ng/ml, in contrast with 18% amongst PD). To note, also in ALS, pathological low levels of vitamin D, comparable to PD, was found. Conclusion: Our findings highlight that vitamin D insufficiency or deficiency is shared by multiple neurodegenerative diseases, albeit a-specifically. In PD, 25(OH) D levels do not correlate with cognitive performance. On one hand, these data confirm the opportunity to restore vitamin D levels in a variety of neurological disorders; on the other, they suggest that, in PD, at contrast with AD, vitamin D insufficiency should not play a relevant role in influencing disease severity or unmasking an associated dementia.

Published
2015

50. A Bayesian approach to Essential Tremor plus: A preliminary analysis of the TITAN cohort.

Author

Erro, Roberto, Pilotto, Andrea, Magistrelli, Luca, Olivola, Enrica, Nicoletti, Alessandra, Di Fonzo, Alessio, Dallocchio, Carlo, Di Biasio, Francesca, Bologna, Matteo, Tessitore, Alessandro, De Rosa, Anna, Gigante, Angelo Fabio, Esposito, Marcello, Moschella, Vincenzo, di Biase, Lazzaro, Valentino, Francesca, Russo, Maria, Contaldi, Elena, Modugno, Nicola, and Padovani, Alessandro

Subjects
*DYSTONIA, *TREMOR, *ESSENTIAL tremor, *PROBABILITY theory, *LONGITUDINAL method
Abstract

Background: The construct of Essential Tremor plus (ET-plus) refers to patients who also have rest tremor and/or mild neurologic signs of unknown significance. It is unclear whether soft signs represent confounding factors or are useful in suspecting an alternative condition.Methods: Using a Bayesian approach to ET-plus patients recruited in The ITAlian tremor Network (TITAN), we analyzed the probability that these patients do not have ET.Results: The data of 274 ET-plus patients were extracted from the TITAN database. The majority of patients (240/274; 87.5%) had a single soft sign. The post-test probability of not having ET was different according to the specific soft sign: namely, 0.64 (rest tremor); 0.46 (questionable dystonia); 0.85 (questionable bradykinesia); 0.19 (soft gait impairment); and 0.09 (questionable cognitive issues). In patients with multiple soft signs, the post-test probability of not having ET was higher than 50% for 7 out of 11 combinations, accounting for 44.1% of subjects. Overall, the post-test probability of not having ET was higher than 50% in up to 71.5% of ET-plus patients.Discussion: We have here shown that: 1) the soft signs differently contribute in modulating the probability that a patient does not have ET; and 2) the effect of multiple soft signs are not always addictive. Future studies are needed to collect prevalence figures of soft signs in different neurological disorders as well as in the elderly and to calculate their value in predicting the development of an alternative tremor syndrome. [ABSTRACT FROM AUTHOR]

Published
2022
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