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2. Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes

Author

Oliviero, Barbara, Dei Cas, Michele, Zulueta, Aida, Maiello, Roberta, Villa, Alessandro, Martinelli, Carla, Del Favero, Elena, Falleni, Monica, Montavoci, Linda, Varchetta, Stefania, Mele, Dalila, Donadon, Matteo, Soldani, Cristiana, Franceschini, Barbara, Maestri, Marcello, Piccolo, Gaetano, Barabino, Matteo, Bianchi, Paolo Pietro, Banales, Jesus M., Mantovani, Stefania, Mondelli, Mario U., and Caretti, Anna

Published
2023
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3. FRI-514 Fatty acids accumulate in intrahepatic cholangiocarcinomaderived tissue and sera

Author

Mantovani, Stefania, primary, Dei Cas, Michele, additional, Oliviero, Barbara, additional, Montavoci, Linda, additional, Falleni, Monica, additional, Tosi, Delfina, additional, Donadon, Matteo, additional, Maestri, Marcello, additional, Barabino, Matteo, additional, Piccolo, Gaetano, additional, Mondelli, Mario Umberto, additional, and Caretti, Anna, additional

Published
2024
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4. Long‐term dynamics of natural killer cells in response to SARS‐CoV‐2 vaccination: Persistently enhanced activity postvaccination

Author

Mele, Dalila, primary, Ottolini, Sabrina, additional, Lombardi, Andrea, additional, Conteianni, Daniela, additional, Bandera, Alessandra, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Cassaniti, Irene, additional, Baldanti, Fausto, additional, Gori, Andrea, additional, Mondelli, Mario U., additional, and Varchetta, Stefania, additional

Published
2024
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5. Unique immunological profile in patients with COVID-19

Author

Varchetta, Stefania, Mele, Dalila, Oliviero, Barbara, Mantovani, Stefania, Ludovisi, Serena, Cerino, Antonella, Bruno, Raffaele, Castelli, Alberto, Mosconi, Mario, Vecchia, Marco, Roda, Silvia, Sachs, Michele, Klersy, Catherine, and Mondelli, Mario U.

Published
2021
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7. VDAC1 selective molecules promote patients’-derived cancer organoids death through mitochondrial-dependent metabolic interference

Author

Conti Nibali, Stefano, primary, De Siervi, Silvia, additional, Luchinat, Enrico, additional, Magrì, Andrea, additional, Brocca, Lorenza, additional, Mantovani, Stefania, additional, Oliviero, Barbara, additional, Mondelli, Mario U., additional, De Pinto, Vito, additional, Turato, Cristian, additional, Arrigoni, Cristina, additional, and Lolicato, Marco, additional

Published
2023
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12. Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host's Immunity.

Author

Mondelli, Mario U., Ottolini, Sabrina, Oliviero, Barbara, Mantovani, Stefania, Cerino, Antonella, Mele, Dalila, and Varchetta, Stefania

Subjects
HEPATITIS C virus, T-cell exhaustion, IMMUNITY, VACCINE effectiveness, IMMUNE response
Abstract

Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of the host's immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct-acting antivirals (DAA) has created hope for the progressive elimination of chronic HCV infections; however, this approach requires a monumental global effort. HCV elicits a prompt innate immune response in the host, characterized by a robust production of interferon-α (IFN-α), although interference in IFN-α signaling by HCV proteins may curb this effect. The late appearance of largely ineffective neutralizing antibodies and the progressive exhaustion of T cells, particularly CD8 T cells, result in the inability to eradicate the virus in most infected patients. Moreover, an HCV cure resulting from DAA treatment does not completely restore the normal immunologic homeostasis. Here, we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes.

Author

Oliviero, Barbara, primary, Cas, Michele Dei, additional, Zulueta, Aida, additional, Maiello, Roberta, additional, Villa, Alessandro, additional, Martinelli, Carla, additional, Favero, Elena Del, additional, Falleni, Monica, additional, Montavoci, Linda, additional, Varchetta, Stefania, additional, Mele, Dalila, additional, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Maestri, Marcello, additional, Piccolo, Gaetano, additional, Barabino, Matteo, additional, Bianchi, Paolo, additional, Banales, Jesus M, additional, Mantovani, Stefania, additional, Mondelli, Mario, additional, and Caretti, Anna, additional

Published
2023
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16. Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells

Author

Mantovani, Stefania, primary, Varchetta, Stefania, additional, Mele, Dalila, additional, Maiello, Roberta, additional, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Torzilli, Guido, additional, Tartaglia, Giuseppe, additional, Maestri, Marcello, additional, Piccolo, Gaetano, additional, Barabino, Matteo, additional, Opocher, Enrico, additional, Bernuzzi, Stefano, additional, Mondelli, Mario U., additional, and Oliviero, Barbara, additional

Published
2022
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20. MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma

Author

Oliviero, Barbara, primary, Varchetta, Stefania, additional, Mele, Dalila, additional, Pessino, Greta, additional, Maiello, Roberta, additional, Falleni, Monica, additional, Tosi, Delfina, additional, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Torzilli, Guido, additional, Piccolo, Gaetano, additional, Barabino, Matteo, additional, Opocher, Enrico, additional, Maestri, Marcello, additional, Bernuzzi, Stefano, additional, Wucherpfennig, Kai W., additional, Mondelli, Mario U., additional, and Mantovani, Stefania, additional

Published
2022
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21. High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders

Author

Mele, Dalila, primary, Calastri, Anna, additional, Maiorano, Eugenia, additional, Cerino, Antonella, additional, Sachs, Michele, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Baldanti, Fausto, additional, Bruno, Raffaele, additional, Benazzo, Marco, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Mondelli, Mario U., additional, and Varchetta, Stefania, additional

Published
2021
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24. A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C

Author

Varchetta, Stefania, primary, Mele, Dalila, additional, D'Ambrosio, Roberta, additional, Perbellini, Riccardo, additional, Lombardi, Andrea, additional, Rojas, Angela, additional, Paolucci, Stefania, additional, Baldanti, Fausto, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Tinelli, Carmine, additional, De Silvestri, Annalisa, additional, Romero Gomez, Manuel, additional, Lampertico, Pietro, additional, and Mondelli, Mario U., additional

Published
2021
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25. SARS Cov-2 infection in a renal-transplanted patient: A case report

Author

Seminari, Elena, Colaneri, Marta, Sambo, Margherita, Gallazzi, Ilaria, Di Matteo, Angela, Roda, Silvia, Bruno, Raffaele, Mondelli, Mario U., Brunetti, Enrico, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Sciarra, Marco, Asperges, Erika, Di Filippo, Alessandro, Biscarini, Simona, Lupi, Matteo, Pieri, Teresa C., Sachs, Michele, Valsecchi, Pietro, Perlini, Stefano, Alfano, Claudia, Bonzano, Marco, Briganti, Federica, Crescenzi, Giuseppe, Falchi, Anna G., Guarnone, Roberta, Guglielmana, Barbara, Maggi, Elena, Martino, Ilaria, Pettenazza, Pietro, Pioli di Marco, Serena, Quaglia, Federica, Sabena, Anna, Salinaro, Francesco, Speciale, Francesco, Zunino, Ilaria, De Lorenzo, Marzia, Secco, Gianmarco, Dimitry, Lorenzo, Cappa, Giovanni, Maisak, Igor, Chiodi, Benedetta, Sciarrini, Massimiliano, Barcella, Bruno, Resta, Flavia, Moroni, Luca, Vezzoni, Giulia, Scattaglia, Lorenzo, Boscolo, Elisa, Zattera, Caterina, Fidel, Tassi M., Vincenzo, Capozza, Vignaroli, Damiano, Bazzini, Marco, Iotti, Giorgio, Mojoli, Francesco, Belliato, Mirko, Perotti, Luciano, Mongodi, Silvia, Tavazzi, Guido, Marseglia, Gianluigi, Licari, Amelia, Brambilla, Ilaria, Daniela, Barbarini, Antonella, Bruno, Patrizia, Cambieri, Giulia, Campanini, Giuditta, Comolli, Marta, Corbella, Rossana, Daturi, Milena, Furione, Bianca, Mariani, Roberta, Maserati, Enza, Monzillo, Stefania, Paolucci, Maurizio, Parea, Elena, Percivalle, Antonio, Piralla, Francesca, Rovida, Antonella, Sarasini, Maurizio, Zavattoni, Guy, Adzasehoun, Laura, Bellotti, Ermanna, Cabano, Giuliana, Casali, Luca, Dossena, Gabriella, Frisco, Gabriella, Garbagnoli, Alessia, Girello, Viviana, Landini, Claudia, Lucchelli, Valentina, Maliardi, Simona, Pezzaia, Marta, Premoli, Alice, Bonetti, Giacomo, Caneva, Irene, Cassaniti, Alfonso, Corcione, Di Martino, Raffella, Di Napoli, Annapia, Alessandro, Ferrari, Guglielmo, Ferrari, Loretta, Fiorina, Federica, Giardina, Alessandra, Mercato, Federica, Novazzi, Giacomo, Ratano, Beatrice, Rossi, Maria, Sciabica I., Monica, Tallarita, Edoardo, Vecchio N., Cerino, Antonella, Varchetta, Stefania, Oliviero, Barbara, Mantovani, Stefania, Mele, Dalila, Calvi, Monica, Tizzonis, Michela, Nicora, Carlo, Triarico, Antonio, Petronella, Vincenzo, Marena, Carlo, Muzzi, Alba, Lago, Paolo, Comandatore, Francesco, Bissignandi, Gherard, Gaiarsa, Stefano, Rettani, Marco, and Band, Claudio

Subjects
Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, infectious disease, Disease, 030230 surgery, clinical research/practice, Asymptomatic, Tacrolimus, Kidney Failure, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Glomerulonephritis, medicine, Extracorporeal membrane oxygenation, Immunology and Allergy, immunosuppressant – calcineurin inhibitor: tacrolimus, infection and infectious agents – viral, COVID-19, Ceftriaxone, Coronavirus Infections, Cytokines, Glomerulonephritis, IGA, Humans, Immunosuppression Therapy, Kidney Failure, Chronic, Middle Aged, Mycophenolic Acid, Pandemics, Pneumonia, Viral, SARS-CoV-2, Treatment Outcome, Kidney Transplantation, Pharmacology (medical), Viral, Chronic, Intensive care medicine, Kidney transplantation, IGA, Mechanical ventilation, Transplantation, business.industry, Immunosuppression, Pneumonia, medicine.disease, medicine.symptom, Cytokine storm, business
Abstract

The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient infected with SARS CoV-2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can "be protective" as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.

Published
2020

28. An Anti-MICA/B Antibody and IL-15 Rescue Altered NKG2D-Dependent NK Cell Responses in Hepatocellular Carcinoma

Author

Mantovani, Stefania, primary, Varchetta, Stefania, additional, Mele, Dalila, additional, Donadon, Matteo, additional, Torzilli, Guido, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Porta, Camillo, additional, Chiellino, Silvia, additional, Pedrazzoli, Paolo, additional, Santambrogio, Roberto, additional, Barabino, Matteo, additional, Cigala, Claudia, additional, Piccolo, Gaetano, additional, Opocher, Enrico, additional, Maestri, Marcello, additional, Sangiovanni, Angelo, additional, Bernuzzi, Stefano, additional, Lhospice, Florence, additional, Kraiem, Manel, additional, Mondelli, Mario Umberto, additional, and Oliviero, Barbara, additional

Published
2020
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30. Unique immunological profile in patients with COVID-19

Author

Varchetta, Stefania, primary, Mele, Dalila, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Ludovisi, Serena, additional, Cerino, Antonella, additional, Bruno, Raffaele, additional, Castelli, Alberto, additional, Mosconi, Mario, additional, Vecchia, Marco, additional, Roda, Silvia, additional, Sachs, Michele, additional, Klersy, Catherine, additional, and Mondelli, Mario U., additional

Published
2020
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33. High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders.

Author

Mele, Dalila, Calastri, Anna, Maiorano, Eugenia, Cerino, Antonella, Sachs, Michele, Oliviero, Barbara, Mantovani, Stefania, Baldanti, Fausto, Bruno, Raffaele, Benazzo, Marco, Grifoni, Alba, Sette, Alessandro, Mondelli, Mario U., and Varchetta, Stefania

Subjects
SARS-CoV-2, T cells, TASTE disorders, SMELL disorders, ACUTE phase proteins, IMMUNOLOGIC diseases
Abstract

Olfactory and taste disorders (OTD) are commonly found as presenting symptoms of SARS-CoV-2 infection in patients with clinically mild COVID-19. Virus-specific T cells are thought to play an important role in the clearance of SARS-CoV-2; therefore the study of T cell specific immune responses in patients with mild symptoms may help to understand their possible role in protection from severe disease. We evaluated SARS-CoV-2-specific T cell responses to four different peptide megapools covering all SARS-CoV-2 proteins during the acute phase of the disease in 33 individuals with mild or no other symptom beside OTD and in 22 age-matched patients with severe infection. A control group of 15 outpatients with OTD and consistently negative nasopharyngeal SARS-CoV-2 RNA swabs and virus-specific IgG serology was included in the study. Increased frequencies of virus-specific CD4+ and CD8+ T cells were found in SARS-CoV-2 positive patients with OTD compared with those with severe COVID-19 and with SARS-CoV-2 negative OTD individuals. Moreover, enhanced CD4+ and CD8+ T-cell activation induced by SARS-CoV-2 peptides was associated with higher interferon (IFN)γ production. Increased frequencies of Spike (S1/S2)-specific CD4+ T cells showing enhanced IFNγ secretion and granzyme B content were associated with serum spike-specific IgG in the OTD group. In conclusion, patients with SARS-CoV-2 induced OTD develop highly functional virus-specific CD4+ and CD8+ T cells during the symptomatic phase of the disease, suggesting that robust and coordinated T-cell responses provide protection against extension of COVID-19 to the lower respiratory tract. [ABSTRACT FROM AUTHOR]

Published
2021
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37. THU-482-A human anti-MICA/B antibody boost NK cell responses in hepatocellular carcinoma

Author

MANTOVANI, STEFANIA, primary, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Santambrogio, Roberto, additional, Cigala, Claudia, additional, Maestri, Marcello, additional, Porta, Camillo, additional, Varchetta, Stefania, additional, Mele, Dalila, additional, Mondelli, Mario Umberto, additional, and Oliviero, Barbara, additional

Published
2019
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38. Deficient Natural Killer Cell NKp30‐Mediated Function and Altered NCR3 Splice Variants in Hepatocellular Carcinoma

Author

Mantovani, Stefania, primary, Oliviero, Barbara, additional, Lombardi, Andrea, additional, Varchetta, Stefania, additional, Mele, Dalila, additional, Sangiovanni, Angelo, additional, Rossi, Giorgio, additional, Donadon, Matteo, additional, Torzilli, Guido, additional, Soldani, Cristiana, additional, Porta, Camillo, additional, Pedrazzoli, Paolo, additional, Chiellino, Silvia, additional, Santambrogio, Roberto, additional, Opocher, Enrico, additional, Maestri, Marcello, additional, Bernuzzi, Stefano, additional, Rossello, Armando, additional, Clément, Sophie, additional, De Vito, Claudio, additional, Rubbia‐Brandt, Laura, additional, Negro, Francesco, additional, and Mondelli, Mario U., additional

Published
2019
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44. Lack of Siglec-7 expression identifies a dysfunctional natural killer cell subset associated with liver inflammation and fibrosis in chronic HCV infection

Author

Varchetta, Stefania, primary, Mele, Dalila, additional, Lombardi, Andrea, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Tinelli, Carmine, additional, Spreafico, Marta, additional, Prati, Daniele, additional, Ludovisi, Serena, additional, Ferraioli, Giovanna, additional, Filice, Carlo, additional, Aghemo, Alessio, additional, Lampertico, Pietro, additional, Facchetti, Floriana, additional, Bernuzzi, Francesca, additional, Invernizzi, Pietro, additional, and Mondelli, Mario U, additional

Published
2015
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46. Lack of Siglec-7 expression identifies a dysfunctional natural killer cell subset associated with liver inflammation and fibrosis in chronic HCV infection.

Author

Varchetta, Stefania, Mele, Dalila, Lombardi, Andrea, Oliviero, Barbara, Mantovani, Stefania, Tinelli, Carmine, Spreafico, Marta, Prati, Daniele, Ludovisi, Serena, Ferraioli, Giovanna, Filice, Carlo, Aghemo, Alessio, Lampertico, Pietro, Facchetti, Floriana, Bernuzzi, Francesca, Invernizzi, Pietro, and Mondelli, Mario U.

Subjects
CHRONIC hepatitis C, PROTEIN expression, CELL membranes, MEMBRANE proteins, FIBROSIS, PROTEOMICS
Published
2016
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48. Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection

Author

Oliviero, Barbara, primary, Mele, Dalila, additional, Degasperi, Elisabetta, additional, Aghemo, Alessio, additional, Cremonesi, Eleonora, additional, Rumi, Maria Grazia, additional, Tinelli, Carmine, additional, Varchetta, Stefania, additional, Mantovani, Stefania, additional, Colombo, Massimo, additional, and Mondelli, Mario U., additional

Published
2013
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50. Reconstitution dynamics of plasmacytoid and myeloid dendritic cell precursors after allogeneic myeloablative hematopoietic stem cell transplantation

Author

Fagnoni, Francesco F, Oliviero, Barbara, Giorgiani, Giovanna, De Stefano, Piero, Dehò, Anna, Zibera, Carlo, Gibelli, Nadia, Maccario, Rita, Da Prada, Gianantonio, Zecca, Marco, Locatelli, Franco, Locatelli, Franco (ORCID:0000-0002-7976-3654), Fagnoni, Francesco F, Oliviero, Barbara, Giorgiani, Giovanna, De Stefano, Piero, Dehò, Anna, Zibera, Carlo, Gibelli, Nadia, Maccario, Rita, Da Prada, Gianantonio, Zecca, Marco, Locatelli, Franco, and Locatelli, Franco (ORCID:0000-0002-7976-3654)

Abstract

Dendritic cells (DCs) are fundamental for immunity. We investigated reconstitution of plasmacytoid DC (PDC) and myeloid DC (My-DC) precursors in the first 2 months after allogeneic hematopoietic stem cell transplantation (Allo-HSCT). Circulating DCs were monitored from the earliest phase of hematopoietic reconstitution in 43 children given standard therapy to prevent graft-versus-host disease (GVHD) and either treated or untreated with granulocyte colony-stimulating factor (G-CSF) after HSCT. In patients without GVHD, both My-DCs and PDCs reached consistently high absolute values during the initial phase. Time of engraftment did not differ between My-DCs and PDCs, regardless of administration of G-CSF. Treatment with G-CSF (1) accelerated early recovery of My-DC absolute numbers; (2) was associated with lower numbers of both My-DCs and PDCs in the later phase; and (3) significantly reduced the proportion of interleukin-12 (IL-12)secreting cells. In some patients who developed acute GVHD, we found high numbers of circulating DC precursors during the early phase of this complication. However, treatment with steroids invariably induced rapid decrease of PDCs. Altogether, these data provide an evaluation of DC release after Allo-HSCT, indicate that postgrafting administration of G-CSIF impairs the appearance of IL-12-producing DCs, and suggest that DC homeostasis may be disrupted at onset of GVHD.

Published
2004

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