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5 results on '"Olivieri, M. C."'

1. The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs

Author

Poole, D., Finazzi, S., Nattino, G., Radrizzani, D., Gristina, G., Malacarne, P., Livigni, S., Bertolini, G., Sorgato, C., Mannoni, R., Agnelli, V., Chiani, C., Lanza, G., Venturini, E., Gianni, M., Olivieri, M. C., Guerriero, B., Della Mora, E., Palmer, M., Blasetti, A., Coletta, R., Covani Frigieri, F., Guarducci, M. D., Caracciolo, A., Lain, G., Bernard, M., DE Blasio, E., Zanni, V., Marchesi, G., Madeira, S. M., Spagarino, E., Potalivo, A., Mengoli, F., Parrini, V., Sagliaschi, U., Prandini, A., Rosano, A., Natalini, G., Piccioni, G., Schiavuzzi, M., Bronzini, N., Piva, S., Besozzi, A., Napoleone, A., Patrignani, L., Pisu, M., Mancosu, S., Chiarello, M., Pastorini, S., Bassi, G., Negro, G., Orsini, I., Marifoglou, D., Pota, V., Pegoraro, M., Sucre, M. J., DI Masi, P., Castiglione, G., Morello, G., Garofalo, G., Caroleo, S., Visconti, M. G., Gamberini, E., Mastroianni, A., Liccardi, M. M., Anelati, D., Martinelli, S., Bonato, A., Adorni, A., Colombo, D., Dal Cero, P., Crema, L., Petrucci, N., Beck, E., Alleva, S., Giuntini, R., DA Re, D., Casalini, P., Fabi, M. C., Galeotti, E., Bagalini, G., Bellonzi, A., Zoppellari, R., Lamborghini, S., Pera, L., Doni, L., Bonizzoli, M., Librenti, M., Barattini, M., Mangani, V., Terzitta, M., Guagliardi, C., Bruzzone, C., Arditi, E., Cerana, M., Tavola, M., Falini, S., Vespignani, M. G., Salvi, G., Ramello, P. L., Molesi, A., Ceradelli, M., Buonanno, R., Righini, E., DI Cocco, A., DI Martino, R., Cinque, E., Bonfiglio, M., Ciceri, R., Colombo, L., Nardini, M., Rossi, G., Boccalatte-Rosa, D. L., Babini, M., Zompanti, V., Negri, G., Antonini, B., Baratta, A., Zuccaro, F., Rossi, M., Pedeferri, M., Bellin, M., Sicignano, A., Pezzi, A., Leggieri, C., Fontana, G., Faraldi, L., Cigada, M. G., Magenta, P., Colombo, R., Colombo, S., Gonzi, S., Pizzali, M., Girardis, M., Piccinini, P., Bignone, P., Padovan, L., Bianchin, A., Caria, F. C., Randellini, R., Roticiani, V., Grassi, M., Belluomo Anello, C., Decristofaro, M., Postiglione, M., Giacomello, S., Olivieri, C., Vaccari, C., Dal Ferro, M., Messina, M., Belgiorno, N., Odetto, L., Pasetti, G. S., Balicco, B., Pizzaballa, M. L., Muraro, L., Pignataro, A., Guadagna, A., Fabbri, P. G., Tetamo, R., Bottazzi, A., Mediani, T. S., Gorietti, A., Breschi, C., Ciani, A., Segalini, P., Codeluppi, V., Berruto, F., Pastorelli, M., Comite, C., Pelati, E., Bertolini, R., Lefons, U., DI Pasquale, D. A., Mannolini, G., Vlassich, F., Becarelli, S., Garelli, A., Salsi, P., Rossi, S., Facondini, F., Alampi, D., Cingolani, E., Molino, F. M., Nardi, G., Casula, M., DE Blasi, R. A., Vulcano, G. A., Azzolini, M., Bernasconi, M. O., Bellato, V., Calicchio, G., Righetti, F., Turati, M., Dei Poli, M., Zaro, G., Brizio, E., Coaloa, M., Falzetti, G., Mamprin, F., Liverani, C. M., Clementi, S., Bonucci, P., Varesio, V., Pannacci, R., Fiore, G., Gallo, M., Torta, M., Selvaggi, P., Bert, P. P., Segala, V., Pettazzi, G., Bensi, M., Bocchi, A., Cima, M., Morbelli, M., Peta, M., DI Stella, R., Maggiolo, C., Lembo, R., Pero, A., Marafon, S., Carnevale, L., Vanzino, R., Vecchiarelli, P., and Marino, G.

Subjects
Male, medicine.medical_specialty, Cirrhosis, Disease, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Patient Admission, Postoperative Complications, law, Internal medicine, 80 and over, aged, critical care, prognosis, Medicine, Dementia, Humans, Hospital Mortality, Elective surgery, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Critical care, Prognosis, Female, Intensive Care Units, Italy, Chronic Disease, 030208 emergency & critical care medicine, Odds ratio, medicine.disease, Comorbidity, Intensive care unit, Anesthesiology and Pain Medicine, 030228 respiratory system, Cohort, business
Abstract

BACKGROUND The number of elderly patients undergoing major surgical interventions and then needing admission to intensive care unit (ICU) grows steadily. We investigated this issue in a cohort of 232,278 patients admitted in five years (2011-2015) to 163 Italian general ICUs. METHODS Surgical patients older than 75 registered in the GiViTI MargheritaPROSAFE project were analyzed. The impact on hospital mortality of important chronic conditions (severe COPD, NYHA class IV, dementia, end-stage renal disease, cirrhosis with portal hypertension) was investigated with two prognostic models developed yearly on patients staying in the ICU less or more than 24 hours. RESULTS 44,551 elderly patients (19.2%) underwent emergency (47.3%) or elective surgery (52.7%). At least one severe comorbidity was present in 14.6% of them, yielding a higher hospital mortality (32.4%, vs. 21.1% without severe comorbidity). In the models for patients staying in the ICU 24 hours or more, cirrhosis, NYHA class IV, and severe COPD were constant independent predictors of death (adjusted odds ratios [ORs] range 1.67-1.97, 1.54-1.91, and 1.34-1.50, respectively), while dementia was statistically significant in four out of five models (adjusted ORs 1.23-1.28). End-stage renal disease, instead, never resulted to be an independent prognostic factor. For patients staying in the ICU less than 24 hours, chronic comorbidities were only occasionally independent predictors of death. CONCLUSIONS Our study confirms that elderly surgical patients represent a relevant part of all ICUs admissions. About one of seven bear at least one severe chronic comorbidity, that, excluding end-stage renal disease, are all strong independent predictors of hospital death.

Published
2017

2. Current adoption of lung ultrasound in Intensive Care Units: An Italian multi-center survey

Author

Calamai, I, Greco, M, Bertolini, G, Spina, R, Adorni, A, Andreoni, P, Babini, M, Bellonzi, A, Bernasconi, M, Berruto, F, Bonfiglio, M, Boniotti, C, Bonucci, P, Bossi, L, Bottazzi, A, Buonanno, R, Buscaglia, G, Candido, M, Caracciolo, A, Carrara, G, Casalini, P, Ceradelli, M, Ciani, A, Clementi, S, Cocciolo, F, Crema, L, Dal Cero, P, Di Masi, P, Di Pasquale, D, Fabi, M, Facondini, F, Falini, S, Falzetti, G, Faraldi, L, Galeotti, E, Ghillino, E, Gianni, M, Giudici, R, Giuntini, R, Gorietti, A, Grioni, A, Guadagnucci, A, Guagliardi, C, Guarducci, M, Laici, C, Lefons, U, Livigni, S, Malacarne, P, Manzi, R, Marafon, S, Marchesi, G, Marchi, M, Marudi, A, Mediani, T, Meinardi, S, Messina, M, Modano, P, Morello, G, Nardi, G, Nardini, M, Nascimben, E, Nattino, G, Negro, G, Neri, M, Olivieri, C, Olivieri, M, Parrini, V, Pasetti, G, Passafiume, M, Pellicioli, I, Pompa, C, Postiglione, M, Raffaeli, M, Righetti, F, Rossi, S, Sacchi, M, Salsi, P, Sciacca, P, Sicignano, A, Silvestri, S, Sparicio, D, Terzitta, M, Tibaldi, G, Todesco, L, Vaj, M, Vulcano, G, Zamperoni, A, Zappa, S, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Mengoli, F, Palma, D, Poole, D, Portolani, L, Radrizzani, D, Tavola, M, Calamai I., Greco M., Bertolini G., Spina R., Adorni A., Andreoni P., Babini M., Bellonzi A., Bernasconi M., Berruto F., Bonfiglio M., Boniotti C., Bonucci P., Bossi L., Bottazzi A., Buonanno R., Buscaglia G., Candido M., Caracciolo A., Carrara G., Casalini P., Ceradelli M., Ciani A., Clementi S., Cocciolo F., Crema L., Dal Cero P., Di Masi P., Di Pasquale D., Fabi M. C., Facondini F., Falini S., Falzetti G., Faraldi L., Galeotti E., Ghillino E., Gianni M., Giudici R., Giuntini R., Gorietti A., Grioni A., Guadagnucci A., Guagliardi C., Guarducci M. D., Laici C., Lefons U., Livigni S., Malacarne P., Manzi R. C., Marafon S., Marchesi G., Marchi M., Marudi A., Mediani T. S., Meinardi S., Messina M., Modano P., Morello G., Nardi G., Nardini M., Nascimben E., Nattino G., Negro G., Neri M., Olivieri C., Olivieri M. C., Parrini V., Pasetti G., Passafiume M., Pellicioli I., Pompa C. P., Postiglione M., Raffaeli M., Righetti F., Rossi S., Sacchi M., Salsi P., Sciacca P. F., Sicignano A., Silvestri S., Sparicio D., Terzitta M., Tibaldi G., Todesco L., Vaj M., Vulcano G. A., Zamperoni A., Zappa S., Zuccaro F., Barattini M., Chieregato A., Fumagalli R., Mengoli F., Palma D., Poole D., Portolani L., Radrizzani D., Tavola M., Calamai, I, Greco, M, Bertolini, G, Spina, R, Adorni, A, Andreoni, P, Babini, M, Bellonzi, A, Bernasconi, M, Berruto, F, Bonfiglio, M, Boniotti, C, Bonucci, P, Bossi, L, Bottazzi, A, Buonanno, R, Buscaglia, G, Candido, M, Caracciolo, A, Carrara, G, Casalini, P, Ceradelli, M, Ciani, A, Clementi, S, Cocciolo, F, Crema, L, Dal Cero, P, Di Masi, P, Di Pasquale, D, Fabi, M, Facondini, F, Falini, S, Falzetti, G, Faraldi, L, Galeotti, E, Ghillino, E, Gianni, M, Giudici, R, Giuntini, R, Gorietti, A, Grioni, A, Guadagnucci, A, Guagliardi, C, Guarducci, M, Laici, C, Lefons, U, Livigni, S, Malacarne, P, Manzi, R, Marafon, S, Marchesi, G, Marchi, M, Marudi, A, Mediani, T, Meinardi, S, Messina, M, Modano, P, Morello, G, Nardi, G, Nardini, M, Nascimben, E, Nattino, G, Negro, G, Neri, M, Olivieri, C, Olivieri, M, Parrini, V, Pasetti, G, Passafiume, M, Pellicioli, I, Pompa, C, Postiglione, M, Raffaeli, M, Righetti, F, Rossi, S, Sacchi, M, Salsi, P, Sciacca, P, Sicignano, A, Silvestri, S, Sparicio, D, Terzitta, M, Tibaldi, G, Todesco, L, Vaj, M, Vulcano, G, Zamperoni, A, Zappa, S, Zuccaro, F, Barattini, M, Chieregato, A, Fumagalli, R, Mengoli, F, Palma, D, Poole, D, Portolani, L, Radrizzani, D, Tavola, M, Calamai I., Greco M., Bertolini G., Spina R., Adorni A., Andreoni P., Babini M., Bellonzi A., Bernasconi M., Berruto F., Bonfiglio M., Boniotti C., Bonucci P., Bossi L., Bottazzi A., Buonanno R., Buscaglia G., Candido M., Caracciolo A., Carrara G., Casalini P., Ceradelli M., Ciani A., Clementi S., Cocciolo F., Crema L., Dal Cero P., Di Masi P., Di Pasquale D., Fabi M. C., Facondini F., Falini S., Falzetti G., Faraldi L., Galeotti E., Ghillino E., Gianni M., Giudici R., Giuntini R., Gorietti A., Grioni A., Guadagnucci A., Guagliardi C., Guarducci M. D., Laici C., Lefons U., Livigni S., Malacarne P., Manzi R. C., Marafon S., Marchesi G., Marchi M., Marudi A., Mediani T. S., Meinardi S., Messina M., Modano P., Morello G., Nardi G., Nardini M., Nascimben E., Nattino G., Negro G., Neri M., Olivieri C., Olivieri M. C., Parrini V., Pasetti G., Passafiume M., Pellicioli I., Pompa C. P., Postiglione M., Raffaeli M., Righetti F., Rossi S., Sacchi M., Salsi P., Sciacca P. F., Sicignano A., Silvestri S., Sparicio D., Terzitta M., Tibaldi G., Todesco L., Vaj M., Vulcano G. A., Zamperoni A., Zappa S., Zuccaro F., Barattini M., Chieregato A., Fumagalli R., Mengoli F., Palma D., Poole D., Portolani L., Radrizzani D., and Tavola M.

Abstract

BACKGROUND: Lung ultrasound (LUS) is a useful tool for assessing lung status in critically ill patients, but is not widely applied in intensive care units (ICUs). The aim of this study was to investigate the use of LUS in Italian ICUs. METHODS: A questionnaire was distributed to 116 ICU representatives belonging to the Italian GiViTI network, participating in a national project on continuous quality of care assessment. The answers to the questionnaire were analyzed with the data collected in the course of said project. RESULTS: 87 ICUs took part in the study. LUS was performed in 94.3% of them, generally by an internal intensivist. The mean number of tests per bed per week was 0.97 (SD, 1.0). A standardized reporting format was present in only 11% of ICUs. LUS was generally used to investigate known or suspected diseases and as a screening tool in only 10%. The number of testes per bed per week was inversely correlated to the number of beds per physician (P<0.001) and to the provider performing the LUS (P<0.001), but not to other structural, organizational or performance data. CONCLUSIONS: LUS is performed in the majority of ICUs and is generally used to investigate known or suspected diseases. Frequency of use appears to be low and related to selected organizational factors. There is generally no standardized format for reporting LUS findings.

Published
2017

3. Inhibition of hepatic gluconeogenesis by the Rp-diastereomer of adenosine cyclic 3′,5′-phosphorothioate

Author

Dragland-Meserve, C J, Olivieri, M C, and Botelho, L H P

Abstract

The specific intracellular cyclic AMP-dependent protein kinase antagonist, the Rp-diastereomer of adenosine cyclic 3′,5′-phosphorothioate (Rp-cAMPS), inhibited both basal and cyclic AMP-agonist-induced rates of gluconeogenesis in hepatocytes isolated from fasted rats. Incubation of the cells in the presence of pyruvate and lactate and either the Sp-diastereomer of adenosine cyclic 3′,5′-phosphorothioate (Sp-cAMPS) or glucagon produced a concentration-dependent increase in the rate of gluconeogenic glucose production which was shifted to higher concentrations of Sp-cAMPS or glucagon in the presence of Rp-cAMPS. Incubation of the cells with Rp-cAMPS in the absence of agonist produced no increase in the rate of glucose production and, in most cases, 100 microM-Rp-cAMPS resulted in 14-20% decrease in the substrate-stimulated rate of glucose production. Sp-cAMPS-induced gluconeogenesis was inhibited half-maximally at 1 microM-Rp-cAMPS and glucagon-induced gluconeogenesis was inhibited half-maximally at 12 microM-Rp-cAMPS. Approx. 10-15% of the inhibition of gluconeogenesis observed in the presence of Rp-cAMPS was due to conversion of glucose 6-phosphate to liver glycogen, consistent with Rp-cAMPS-induced reactivation of glycogen synthase. The remaining 85-90% inhibition of gluconeogenic glucose production resulted from the action of Rp-cAMPS on the cyclic AMP-sensitive enzymes controlling the rate of gluconeogenesis.

Published
1986
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4. [Pulsed magnetic fields. Observations in 353 patients suffering from chronic pain].

Author

Di Massa A, Misuriello I, Olivieri MC, and Rigato M

Subjects
Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Follow-Up Studies, Humans, Male, Middle Aged, Spinal Diseases therapy, Electromagnetic Fields, Electromagnetic Phenomena, Pain Management
Abstract

Three hundred-fifty-three patients with chronic pain have been treated with pulsed electromagnetic fields. In this work the Authors show the result obtained in the unsteady follow-up (2-60 months). The eventual progressive reduction of benefits is valued by Spearman's test. We noted the better results in the group of patients with post-herpetic pain (deafferentation) and in patients simultaneously suffering from neck and low back pain.

Published
1989

5. Synergistic inhibition of hepatic ketogenesis in the presence of insulin and a cAMP antagonist.

Author

Olivieri MC and Botelho LH

Subjects
3-Hydroxybutyric Acid, Acetoacetates biosynthesis, Animals, Cyclic AMP pharmacology, Drug Synergism, Hydroxybutyrates biosynthesis, Liver drug effects, Male, Rats, Rats, Inbred Strains, Stereoisomerism, Cyclic AMP analogs & derivatives, Cyclic AMP antagonists & inhibitors, Insulin pharmacology, Ketones biosynthesis, Liver metabolism, Thionucleotides pharmacology
Abstract

The separate or combined effects of insulin and the cAMP antagonist, the Rp-diastereomer of adenosine cyclic 3',5'-phosphorothioate (Rp-cAMPS), were examined on fatty acid-stimulated ketogenesis in hepatocytes from normal fasted rats. Addition of 0.4 mM oleic acid or 0.4 mM octanoic acid resulted in a linear increase in ketone production measured over 60 min. When oleic acid was the substrate, incubation with 1 to 30 microns Rp-cAMPS alone or 0.1 to 10 nM insulin alone caused a variable decrease in the production of ketones which did not exceed an average value of 30% in any one experiment. The simultaneous addition of Rp-cAMPS and insulin resulted in a greater than additive inhibition which reached average values between 47-60% when the theoretical combined inhibitory effect of the insulin alone plus the Rp-cAMPS alone was less than 18%. No significant effects of either insulin or Rp-cAMPS, alone or in combination, were seen when octanoic acid was the substrate. These data imply that Rp-cAMPS can potentiate insulin inhibition of hepatic ketogenesis through inhibition of a cAMP-mediated process.

Published
1989
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