Search

International audience; This study aims at suggesting a new approach to peri-implant healing models, providing a set of taxis-diffusion-reaction equations under the combined influence of mechanical and biochemical factors. Early events of osseointegration were simulated for titanium screw implants inserted into a pre-drilled trabecular bone environment, up to twelve weeks of peri-implant bone healing. Simulations showed the ability of the model to reproduce biological events occurring at the implant interface through osteogenesis. Implants with shallow healing chamber showed higher proportions of lamellar bone, enhanced by the increase of mechanical stimulation. Osteoconduction was observed through the surface treatment model and similar bone healing patterns compared to in vivo studies.

Objective: The aim of this study was to assess, through biological analysis, the local effects and osseointegration of dental implants incorporating surface micro/nanofeatures compared to implants of identical design without surface treatment. Background: Known to impact bone cell behavior, surface chemical and topography modifications target improved osseointegration and long-term success of dental implants. Very few studies assess the performance of implants presenting both micro-and nanofeatures in vivo on the animal models used in preclinical studies for medical device certification. Methods: Implant surfaces were characterized in terms of topography and surface chemical composition. After 4 weeks and 13 weeks of implantation in sheep femoral condyles, forty implants were evaluated through micro-computed tomography, histopathologic, and histomorphometric analyses. Results: No local adverse effects were observed around implants. Histomorphometric analyses showed significantly higher bone-to-implant contact in the coronal region of the surface treated implant at week 4 and week 13, respectively 79.3$\pm$11.2% and 86.4$\pm$6.7%, compared to the untreated implant's 68.3$\pm$8.8% and 74.8$\pm$13%. Micro-computed tomography analyses revealed that healing patterns differed between coronal and apical regions, with higher coronal boneto-implant contact at week 13. Histopathologic results showed, at week 13, bone healing around the surface treated implant with undistinguishable defect margins while the untreated implant still presented bone condensation and traces of the initial drill defect. Conclusion: Our results suggest that the surface treated implant not only shows no deleterious effects on local tissues but also promotes faster bone healing around the implant. (word count: 241, Journal of Periodontal Research, Wiley, 2021