1. Mechanobiological model to study the influence of screw design and surface treatment on osseointegration
- Author
-
Jean-Louis Milan, Patrick Chabrand, Nicolas Rousseau, Olivier Richart, Arnaud Destainville, Selenium Medical, 9049 rue de Québec, CS80875, 17043 La Rochelle, France, Aix Marseille Univ, CNRS, ISM, Marseille, France, Abys Medical, 40 rue Chef de Baie, 17000 La Rochelle, France, Institut du Mouvement et de l’appareil Locomoteur [Hôpital Sainte-Marguerite - APHM] (IML), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Rhumatologie [Sainte- Marguerite - APHM] ( Hôpitaux Sud), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Materials science ,Surface Properties ,Bone Screws ,0206 medical engineering ,Surface treatment ,Biomedical Engineering ,Lamellar bone ,Bioengineering ,02 engineering and technology ,Bone healing ,Bone and Bones ,Osseointegration ,Mechanobiological model ,Finite element simulation ,03 medical and health sciences ,Osteogenesis ,030304 developmental biology ,Dental Implants ,Titanium ,0303 health sciences ,Implant design ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,General Medicine ,020601 biomedical engineering ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Computer Science Applications ,Human-Computer Interaction ,Trabecular bone ,Implant ,Biomedical engineering - Abstract
International audience; This study aims at suggesting a new approach to peri-implant healing models, providing a set of taxis-diffusion-reaction equations under the combined influence of mechanical and biochemical factors. Early events of osseointegration were simulated for titanium screw implants inserted into a pre-drilled trabecular bone environment, up to twelve weeks of peri-implant bone healing. Simulations showed the ability of the model to reproduce biological events occurring at the implant interface through osteogenesis. Implants with shallow healing chamber showed higher proportions of lamellar bone, enhanced by the increase of mechanical stimulation. Osteoconduction was observed through the surface treatment model and similar bone healing patterns compared to in vivo studies.
- Published
- 2021