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A glucose-appended bio-compatible Ir(iii) complex which absorbs light strongly, photo-catalytically oxidizes cellular coenzymes NAD(P)H, and decreases the mitochondrial membrane potential, resulting in cancer cell apoptosis and necrosis.

Metals play vital roles in nutrients and medicines and provide chemical functionalities that are not accessible to purely organic compounds. At least 10 metals are essential for human life and about 46 other non-essential metals (including radionuclides) are also used in drug therapies and diagnostic agents. These include platinum drugs (in 50% of cancer chemotherapies), lithium (bipolar disorders), silver (antimicrobials), and bismuth (broad-spectrum antibiotics). While the quest for novel and better drugs is now as urgent as ever, drug discovery and development pipelines established for organic drugs and based on target identification and high-throughput screening of compound libraries are less effective when applied to metallodrugs. Metallodrugs are often prodrugs which undergo activation by ligand substitution or redox reactions, and are multi-targeting, all of which need to be considered when establishing structure–activity relationships. We focus on early-stage in vitro drug discovery, highlighting the challenges of evaluating anticancer, antimicrobial and antiviral metallo-pharmacophores in cultured cells, and identifying their targets. We highlight advances in the application of metal-specific techniques that can assist the preclinical development, including synchrotron X-ray spectro(micro)scopy, luminescence, and mass spectrometry-based methods, combined with proteomic and genomic (metallomic) approaches. A deeper understanding of the behavior of metals and metallodrugs in biological systems is not only key to the design of novel agents with unique mechanisms of action, but also to new understanding of clinically-established drugs., The vital roles of metals in nutrients and medicines are not accessible to purely organic compounds.

Natural minerals (‘stone drugs’) have been used in traditional Chinese medicines for over 2000 years, but there is potential for modern-day use of inorganic minerals to combat viral infections, antimicrobial resistance, and for other areas in need of new therapies and diagnostic aids. Metal and mineral surfaces on scales from milli-to nanometres, either natural or synthetic, are patterned or can be modified with hydrophilic/hydrophobic and ionic/covalent target-recognition sites. They introduce new strategies for medical applications. Such surfaces have novel properties compared to single metal centres. Moreover, 3D mineral particles (including hybrid organo-minerals) can have reactive cavities, and some minerals have dynamic movement of metal ions, anions, and other molecules within their structures. Minerals have a unique ability to interact with viruses, microbes and macro-biomolecules through multipoint ionic and/or non-covalent contacts, with potential for novel applications in therapy and biotechnology. Investigations of mineral deposits in biology, with their often inherent heterogeneity and tendency to become chemically-modified on isolation, are highly challenging, but new methods for their study, including in intact tissues, hold promise for future advances.

While greenhouse gases trap heat emanating from the Earth and thereby heat the surface atmosphere, they act as emitters in the high atmosphere and cool the air there. In 1989 Roble and Dickinson (1989) estimated the cooling that would occur in the thermosphere (250–500 km altitude) due to a doubling of greenhouse gas densities. Ever since, long-term data bases have been scoured for evidence of this thermospheric "global cooling." Here we show evidence that the thermosphere did indeed cool over the period 1966–1987, but the data suggest that the cooling accelerated at a "breakpoint year" around 1979 to a rate far larger than may be attributed to greenhouse cooling. This 1979 breakpoint year appears to coincide with a breakpoint year in ozone (O3) column density. Further, the cooling was confined largely to the daytime thermosphere while the nighttime showed only a small trend. These results suggest, first, that the greenhouse cooling of the thermosphere may well not be detectable with current data sets and, second, that the long-term cooling that is clearly seen may be due largely to O3 depletion.

International audience; The Saint Santin (45 N) incoherent scatter radar data base shows a local enhancement in nighttime ion temperature that occurs in winter only. Its amplitude can exceed 100 K and averages 40 K on the basis of a conservative computation. The enhancement peaks near 4 LT and has a duration of about 4 hours. We discuss two possible explanations for this feature: (1) it is caused by the convergence of global winds at the global pressure minimum, under which Saint Santin rotates at winter solstice, and (2) it is an extension or propagation of the well-known low-latitude midnight temperature maximum to midlatitudes, perhaps to that pressure minimum.

Recent studies of the ion energy balance in the mid-latitude ionosphere have led to the suggestion that hot neutral atomic oxygen may play a significant role; the presence of a population of hot O could explain some of the problems met in balancing the ion energy budget for Incoherent Scatter (IS) observations. The aim of the present study is to look at such effects by using numerical simulation. The TRANSCAR model is a time-dependent, 13-moment ionosphere model developed for high latitude studies. It was first adapted for mid-latitude conditions. In a first step the model was calibrated and cross-checked with St. Santin IS measurements for the winter case of 27 January 1972 around noon using, in particular, the MSIS neutral atmosphere model. This provides a reference diurnal variation of the ionosphere. The second step investigated the influence of a maxwellian population of hot neutral atomic oxygen introduced in addition to the standard neutral atmosphere. The paper describes the initial comparison between the model and St. Santin IS data, and then the effects induced by a hot atomic oxygen population.Key words. Ionosphere (ionosphere-atmosphere interactions; ion chemistry and composition; mid-latitude ionosphere)