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Background: Despite the known need for empirical research-to-policy studies, little is known about the factors and conditions needed to support meaningful evidence use or how to intervene to promote quality evidence use. Aims and objectives: To study research-policy processes empirically and descriptively, we conducted an ethnography that focused on the impact of the Research-to-Policy Collaboration (RPC) on legislator and researcher evidence use or policy engagement, including whether and how researchers and policymakers created and sustained meaningful relationships. Methods: The ethnography included participant observation as well as pre- and post- semi-structured interviews from policymakers (n=17), researchers (n=23), and RPC staff (n=5). The team attended relevant events as well as observed the formal and informal ways research is used in policymaking. Findings: In the paper, we describe how 1) legislative priorities were identified; 2) networks were established and maintained; 3) trainings evolved over time; 4) relationships between RPC staff, congressional staff, and researchers were facilitated; and 5) RPC followed up with policymakers and researchers. Discussion and conclusions: We 1) describe the experiences of participants and whether involvement in the intervention changed attitudes or behaviours about evidence use in policy; 2) describe the RPC process in practice, and how it was implemented and evolved over time; and 3) better understand the conditions supporting evidence use in policymaking. We conclude with the value of the RPC as a resource to fill a niche within the evidence and policy space, as well as suggestions for future research-to-policy programmes and practices.

Background: To improve the use of evidence in policy and practice, many organisations and individuals seek to promote research-policy engagement activities, but little is known about what works. Aims and objectives: We sought (a) to identify existing research-policy engagement activities, and (b) evidence on impacts of these activities on research and decision making. Methods: We conducted systematic desk-based searches for organisations active in this area (such as funders, practice organisations, and universities) and reviewed websites, strategy documents, published evaluations and relevant research. We used a stakeholder roundtable, and follow-up survey and interviews, with a subset of the sample to check the quality and robustness of our approach. Findings: We identified 1923 initiatives in 513 organisations world-wide. However, we found only 57 organisations had publicly-available evaluations, and only 6% (141/2321) of initiatives were evaluated. Most activities aim to improve research dissemination or create relationships. Existing evaluations offer an often rich and nuanced picture of evidence use in particular settings (such as local government), sectors (such as policing), or by particular providers (such as learned societies), but are extremely scarce. Discussion and conclusions: Funders, research- and decision-making organisations have contributed to a huge expansion in research-policy engagement initiatives. Unfortunately, these initiatives tend not to draw on existing evidence and theory, and are mostly unevaluated. The rudderless mass of activity therefore fails to provide useful lessons for those wishing to improve evidence use, leading to wasted time and resources. Future initiatives should draw on existing evidence about what works, seek to contribute to this evidence base, and respond to a more realistic picture of the decision-making context.

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), with approximately 90% of patients harboring at least one copy of the disease-associated variant F508del. We utilized a yeast phenomic system to identify genetic modifiers of F508del-CFTR biogenesis, from which ribosomal protein L12 (RPL12/uL11) emerged as a molecular target. In the present study, we investigated mechanism(s) by which suppression of RPL12 rescues F508del protein synthesis and activity. Using ribosome profiling, we found that rates of translation initiation and elongation were markedly slowed by RPL12 silencing. However, proteolytic stability and patch-clamp assays revealed RPL12 depletion significantly increased F508del-CFTR steady-state expression, interdomain assembly, and baseline open-channel probability. We next evaluated whether Rpl12-corrected F508del-CFTR could be further enhanced with concomitant pharmacologic repair (e.g., using clinically approved modulators lumacaftor and tezacaftor) and demonstrated additivity of these treatments. Rpl12 knockdown also partially restored maturation of specific CFTR variants in addition to F508del, and WT Cftr biogenesis was enhanced in the pancreas, colon, and ileum of Rpl12 haplosufficient mice. Modulation of ribosome velocity therefore represents a robust method for understanding both CF pathogenesis and therapeutic response., Introduction Cystic fibrosis (CF) is caused by abnormalities of the CF transmembrane conductance regulator (CFTR), with the most common variant being F508del (deletion of phenylalanine at position 508). The F508del [...]

Background: Arguments supporting the involvement of users in research have even more weight when involving the public in systematic reviews of research. We aimed to explore the potential for public involvement in systematic reviews of observational and qualitative studies. Methods: Two consultative workshops were carried out with a group of young people (YP) aged 12-17 years to examine two ongoing reviews about obesity: one about children's views and one on the link between obesity and educational attainment. YP were invited to comment on the credibility of themes, to propose elements of interventions, to suggest links between educational attainment and obesity and to comment on their plausibility. Results: Researchers had more confidence in review findings, after checking that themes identified as important by YP were emphasised appropriately. Researchers were able to use factors linking obesity and attainment identified as important by YP to identify limitations in the scope of extant research. Conclusion: Consultative workshops helped researchers draw on the perspectives of YP when interpreting and reflecting upon two systematic reviews. Involving users in judging synthesis credibility and identifying concepts was easier than involving them in interpreting findings. Involvement activities for reviews should be designed with review stage, purpose and group in mind.