223 results on '"Oliveira LP"'
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2. SÍNDROME MIELODISPLÁSICA (SMD) INFANTIL COM CARIÓTIPO COMPLEXO E MANIFESTAÇÃO CUTÂNEA: RELATO DE CASO
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Oliveira, LP, primary, Fernandes, CG, additional, Dias, JO, additional, Pena, ALB, additional, Cardoso, BA, additional, Souza, C, additional, Giovanardi, MF, additional, Maciel, EAW, additional, Guedes, RL, additional, and Tavares, LG, additional
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- 2023
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3. AVALIAÇÃO DOS PACIENTES COM DEFICIÊNCIA DE GLICOSE-6-FOSFATO DESIDROGENASE (G6PD) ACOMPANHADOS EM SERVIÇO PARTICULAR DE HEMATOLOGIA PEDIÁTRICA
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Oliveira, LP, primary, Pena, ALB, additional, Cardoso, BA, additional, Souza, C, additional, Giovanardi, MF, additional, Maciel, EAW, additional, Fernandes, CG, additional, Dias, JO, additional, Tavares, LG, additional, and Fernandes, ABP, additional
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- 2023
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4. ANEMIA HEMOLÍTICA AUTO IMUNE PÓS-INFECÇÃO POR MYCOPLASMA PNEUMONIAE: RELATO DE CASO
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Oliveira, LP, primary, Coelho, IS, additional, Oliveira, LGM, additional, Seidel, H, additional, Fernandes, ABP, additional, and Guedes, RL, additional
- Published
- 2022
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5. TRATAMENTO DE RESGATE COM INIBIDOR DO BCL-2 (VENETOCLAX) EM PACIENTE COM RECIDIVA DA LEUCEMIA LINFOCÍTICA AGUDA (LLA) PÓS TRANSPLANTE DE MEDULA ÓSSEA (TMO)
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Oliveira, LP, primary, Pena, ALB, additional, Cardoso, BA, additional, Giovanardi, MF, additional, Souza, C, additional, and Guedes, RL, additional
- Published
- 2022
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6. LACTENTE COM RECIDIVA MUITO PRECOCE DA LEUCEMIA LINFOCÍTICA AGUDA (LLA) E TRANSFORMAÇÃO PARA A LINHAGEM DE SWITCH DURANTE A INFUSÃO DE BLLINATUMUMAB SUBMETIDA AO TRANSPLANTE DE MEDULA ÓSSEA (TMO)
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Oliveira, LP, primary, Pena, ALB, additional, Cardoso, BA, additional, Giovanardi, MF, additional, Souza, C, additional, and Guedes, RL, additional
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- 2022
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7. DIAGNÓSTICO DIFERENCIAL DE INFECÇÃO POR EPSTEIN-BARR E DOENÇA LINFOPROLIFERATIVA: RELATO DE CASO
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Oliveira, LP, primary, Coelho, IS, additional, Oliveira, LGM, additional, Seidel, H, additional, Fernandes, ABP, additional, and Guedes, RL, additional
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- 2022
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8. Caries and oral health related behaviours among homeless adults from Porto, Portugal
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Pereira, ML, Oliveira, LP, Lunet, N, and Instituto de Saúde Pública
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stomatognathic diseases ,Oral health - Caries - Abstract
Purpose: To describe caries prevalence and oral-health-related behaviours in a sample of homeless adults from the city of Porto, Portugal. Materials and Methods: Subjects attending any of two temporary shelters or two institutions that provide meal programmes were consecutively invited (n = 196); 42 (21.4%) refused to participate. Trained interviewers applied a structured questionnaire to obtain sociodemographic, behavioural, health and oral health status data. An oral examination was conducted to evaluate the past and present history of caries (Decayed Missing Filled Teeth [DMFT] index) and the presence of oral lesions. Those classifi ed as houseless were considered for the present analysis (n = 141). The association between homelessness, sociodemographic and behavioural characteristics and oral health indexes was quantifi ed through crude β coeffi cients and β coeffi cients adjusted for age, gender, education, nationality and duration of homelessness, as well as the respective 95% confi dence intervals (CI). Results: The median age of the participants was 45 years, most were male (86.3%), reported having less than a 9thgrade education (80.1%) and were unemployed (82.1%). The median duration of homelessness was 24 months. The mean (SD) DMFT index, number of decayed, lost and fi lled teeth were 12.8 (7.9), 4.2 (4.4), 8.0 (7.6) and 0.6 (1.9), respectively. Older subjects and those homeless for longer periods presented higher DMFT index scores (β = 3.4, 95% CI: 0.0 to 6.8) and higher number of decayed teeth (β = 2.8, 95% CI: 0.4 to 5.2). Filled teeth were more frequent among the more educated (>9 vs ≤4 years: β = 1.6, 95% CI: 0.7 to 2.6). Conclusions: This population of homeless subjects showed poor oral health, particularly with respect to caries and missing teeth, resulting in high oral treatment needs.
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- 2014
9. Combining transcriptomics-based and proteomics-based approaches for functional characterization of terpene synthases of “Arnica da Serra” (Asteraceae)
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Pavarini, DP, primary, Oliveira, LP, additional, Pereira, LM, additional, Natsui, AP, additional, Spring, O, additional, and Lopes, NP, additional
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- 2013
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10. Comparison of the Recovery Response from High-Intensity and High-Volume Resistance Exercise in Trained Men
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Sandro Bartolomei, Ran Wang, Jeffrey R. Stout, Jay R. Hoffman, Joseph A. Gordon, Eliott Arroyo, Kyle S. Beyer, Alyssa N. Varanoske, Leonardo P. Oliveira, David D. Church, Eliahu Sadres, and Bartolomei S, Sadres E, Church DD, Arroyo E, Gordon JA III, Varanoske AN, Wang R, Beyer KS, Oliveira LP, Stout JR, Hoffman JR
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Adult ,Male ,medicine.medical_specialty ,Sports medicine ,Hydrocortisone ,Physiology ,Squat ,Isometric exercise ,Muscle damage ,High-Intensity Interval Training ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,Lactate dehydrogenase ,Isometric Contraction ,medicine ,Humans ,Orthopedics and Sports Medicine ,Testosterone ,Muscle, Skeletal ,Creatine Kinase ,Leg ,biology ,L-Lactate Dehydrogenase ,Resistance training Performance Testosterone Cortisol Inflammation Muscle damage ,business.industry ,Interleukin-6 ,Myoglobin ,Public Health, Environmental and Occupational Health ,Resistance training ,Resistance Training ,030229 sport sciences ,General Medicine ,Myalgia ,Recovery of Function ,Endocrinology ,C-Reactive Protein ,chemistry ,biology.protein ,Creatine kinase ,business ,030217 neurology & neurosurgery - Abstract
Purpose The purpose of this study was to compare the physiological responses of a high-volume (HV; 8 sets of 10 repetitions) versus high-intensity (HI; 8 sets of 3 repetitions) exercise protocol in resistance-trained men. Methods Twelve men (24.5 ± 4.2 years; 82.3 ± 8.4 kg; 175.2 ± 5.5 cm) with 6.3 ± 3.4 years of resistance training experience performed each protocol in a counterbalanced, randomized order. Performance [counter movement jump peak power (CMJP), isokinetic (ISOK) and isometric leg extension (MVIC), isometric mid-thigh pull (IMTP), and isometric squat (ISQ)] and muscle morphological [cross-sectional area (CSA) of vastus lateralis] assessments were performed at baseline (BL), 30-min (P-30 min), 24-h (P-24 h), 48-h (P-48 h), and 72-h (P-72 h) post-exercise for each testing session. In addition, endocrine (testosterone and cortisol), inflammatory [interleukin-6 (IL-6) and C-reactive protein (CRP)], and markers of muscle damage [creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin (Mb)] were assessed at the same time points. Results Significantly greater reductions in CMJP (p
- Published
- 2017
11. Impact of Complete Intermittent Blood Flow Restriction in Upper Limbs Strength and Neural Function.
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de Castro FMP, Oliveira LP, Aquino R, Tourinho Filho H, and Puggina EF
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- Humans, Male, Young Adult, Female, Adult, Regional Blood Flow physiology, Resistance Training methods, Muscle Strength physiology, Upper Extremity physiology, Upper Extremity blood supply, Muscle, Skeletal physiology, Muscle, Skeletal blood supply, Adaptation, Physiological physiology
- Abstract
Purpose: We aimed to investigate the chronic effects of low-load strength training (LT) with complete intermittent blood flow restriction (IBFR) on neural adaptations and strength in biceps brachii. Methods: Nineteen volunteers were randomly assigned into two different 9-week training protocols consisting of three assessment weeks and six training weeks: (a) LT with complete IBFR (LT-IBFR; n = 10) and (b) LT without complete IBFR (LT; n = 9). Strength was evaluated by predicted 1 repetition maximum (1RM) at weeks 1, 5, and 9 and neural function by root mean square (RMS) and median frequency (MDF) at sessions 1, 7, and 12 during the first three and last three repetitions. Both groups performed three sets of Scott curl with 20% of predicted 1RM interspersed with 90s rest twice a week. Results: No changes were found in predicted 1RM throughout the training protocols nor between groups. LT-IBFR group showed lower RMS in the first set than LT for the first three repetitions and higher RMS in all sets for the last three repetitions with decreases in this value across the sets with no longitudinal changes for both groups. MDF in the first three repetitions did not differentiate between groups, however, in the last three repetitions, MDF were lower for LTIBFR group in all sets and it increased across the sets for this condition with no chronical changes for both groups in both repetitions zones. These results suggest that LT-IBFR may be ineffective for increasing Q5 strength and it did not promote chronic neural adaptations.
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- 2024
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12. Jump Squat Vs. Resisted Sprint Training Programs Applied to Elite Youth Soccer Players: Effects on Sprint and Power-Related Performance.
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Loturco I, Pereira LA, Mercer VP, Oliveira LP, Zanetti V, Lima L, Bastos T, Moura TBMA, and McGuigan MR
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Abstract: Loturco, I, Pereira, LA, Mercer, VP, Oliveira, LP, Zanetti, V, Lima, L, Bastos, T, Moura, TBMA, and McGuigan, MR. Jump squat vs. resisted sprint training programs applied to elite youth soccer players: effects on sprint and power-related performance. J Strength Cond Res XX(X): 000-000, 2024-This study examined the effectiveness of 2 different and widely used training programs on the sprint and power-related performance of youth soccer players. Two distinct training strategies-vertically oriented jump squats (JSs) or horizontally oriented resisted sprints (RSs)-were executed under the same absolute loading conditions (i.e., 30% of the athletes' body mass [BM]) during a 4-week preseason period. Training schemes, loading intensities (based on %BM), and the number of experimental sessions were designed in conjunction with the soccer club's coaching staff, considering the calendar, available resources, and regular training programs. Twenty-five under-17 soccer players performed a series of speed, power, and jump tests before and after 10 resisted training sessions, consisting solely of loaded JS or RS. Overall, neither group (i.e., JS or RS training groups) exhibited any improvement in linear sprint and change-of-direction (COD) speed. Conversely, vertical jumping ability and peak velocity in the loaded JS increased significantly only in the JS group, which may positively affect players' performance and training prescription during short soccer preseasons. Given the challenges in enhancing sprint speed among soccer players during preseasons (and even over the competitive season), coupled with the limited effectiveness of RS in improving sprinting, COD, and jumping capabilities within congested and short training phases (i.e., ≤4 weeks), the regular use of RS training methods during these phases may be highly questionable. Coaches should carefully consider these critical limitations and potential disadvantages when designing neuromuscular training programs for soccer players during the preparatory phases of the annual training season., (Copyright © 2024 National Strength and Conditioning Association.)
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- 2024
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13. Oral health self-perception, maximum bite force and masticatory efficiency in patients with overdentures with different attachment systems-A crossover study.
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de Oliveira Lima AL, Jabr CL, de Melo Rocha CO, Oliveira LP, de Oliveira Ribeiro RA, de Assis Mollo Júnior F, and Arioli Filho JN
- Abstract
Background: The literature is unclear about how the different attachment systems for overdentures impact the maximum bite force, the masticatory efficiency and how this impact in the oral health self-perception in patients., Objective: To evaluate the effect of two attachment systems (O-ring and Locator) for mandibular overdenture using single implant on quality of life, maximum bite force (BF) and masticatory efficiency (ME)., Methods: Twenty-eight completely edentulous denture wearers with a mandibular symphysis implant were randomly selected and allocated into two groups in a crossover study, considering O-ring and Locator attachment types. The quality of life and self-perception of oral health were assessed using the Oral Health Impact Profile (OHIP-Edent) and Geriatric Index of Determination of Oral Health (GOHAI) questionnaires, respectively. BF was measured using a gnathodynamometer and ME by chewing silicone cubes and almonds in different numbers of cycles., Results: There was no difference between the attachment systems about self-perceived oral health and impact on quality of life (p > .05). The O-ring-type system obtained a significantly higher BF than the locator-type system (p = .04). Regardless of the food chewed, no statistically significant difference was observed with the type of attachment (p > .05). The ME was directly proportional to the masticatory cycles only for almonds (p < .01)., Conclusions: Locator and O-ring inserts had a similar impact on patients' quality of life, self-perception of oral health and ME. Additionally, the O-ring system exhibited superior properties in the BF., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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14. Ruthenium(II) complexes of curcumin and β-diketone derivatives: effect of structural modifications on their cytotoxicity.
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Jacinto FE, de Oliveira LP, Batista AA, Oliveira KM, and Correa RS
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Ruthenium(II) complexes ( Ru1 - Ru3 ) with the general formula [Ru(O-O)(PPh
3 )2 (bipy)]PF6, bearing two triphenylphosphine (PPh3 ), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and calf thymus DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780 cis ), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC50 ) values ranging from 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity against the A2780 cis cell line, with IC50 ranging from 0.39 to 0.82 µM. Among them, Ru2 exhibited the highest cytotoxicity, with an IC50 value of 0.39 µM. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents., Competing Interests: We declare we have no competing interests., (© 2024 The Authors.)- Published
- 2024
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15. Exploring the potential of ruthenium(II)-phosphine-mercapto complexes as new anticancer agents.
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Palmeira-Mello MV, Costa AR, de Oliveira LP, Blacque O, Gasser G, and Batista AA
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- Humans, Cell Line, Tumor, Sulfhydryl Compounds chemistry, Sulfhydryl Compounds pharmacology, Cell Proliferation drug effects, Cell Survival drug effects, Drug Screening Assays, Antitumor, Molecular Structure, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Phosphines chemistry, Phosphines pharmacology, Ruthenium chemistry, Ruthenium pharmacology, Coordination Complexes chemistry, Coordination Complexes pharmacology, Coordination Complexes chemical synthesis
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The search for new metal-based anticancer drug candidates is a fundamental task in medicinal inorganic chemistry. In this work, we assessed the potential of two new Ru(II)-phosphine-mercapto complexes as potential anticancer agents. The complexes, with the formula [Ru(bipy)(dppen)(Lx)]PF
6 [(1), HL1 = 2-mercapto-pyridine and (2), HL2 = 2-mercapto-pyrimidine, bipy = 2,2'-bipyridine, dppen = cis -1,2-bis(diphenylphosphino)-ethylene] were synthesized and characterized by nuclear magnetic resonance (NMR) [1 H,31 P(1 H), and13 C], high resolution mass spectrometry (HR-MS), cyclic voltammetry, infrared and UV-Vis spectroscopies. Complex 2 was obtained as a mixture of two isomers, 2a and 2b, respectively. The composition of these metal complexes was confirmed by elemental analysis and liquid chromatography-mass spectrometry (LC-MS). To obtain insights into their lipophilicity, their distribution coefficients between n -octanol/PBS were determined. Both complexes showed affinity mainly for the organic phase, presenting positive log P values. Also, their stability was confirmed over 48 h in different media ( i.e. , DMSO, PBS and cell culture medium) via HPLC, UV-Vis and31 P{1 H} NMR spectroscopies. Since enzymes from the P-450 system play a crucial role in cellular detoxification and metabolism, the microsomal stability of 1, which was found to be the most interesting compound of this study, was investigated using human microsomes to verify its potential oxidation in the liver. The analyses by LC-MS and ESI-MS reveal three main metabolites, obtained by oxidation in the dppen and bipy moieties. Moreover, 1 was able to interact with human serum albumin (HSA). The cytotoxicity of the metal complexes was tested in different cancerous and non-cancerous cell lines. Complex 1 was found to be more selective than cisplatin against MDA-MB-231 breast cancer cells when compared to MCF-10A non-cancerous cells. In addition, complex 1 affects cell morphology and migration, and inhibits colony formation in MDA-MB-231 cells, making it a promising cytotoxic agent against breast cancer.- Published
- 2024
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16. Challenges to the operation of Brazilian LTCIs and changes in oversight.
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de Oliveira LP and da Silva HS
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- Brazil, Humans, Cross-Sectional Studies, Aged, Homes for the Aged standards, Qualitative Research, Long-Term Care methods
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Background: Despite 18 years since health surveillance regulations were promulgated in Brazil to govern Long-Term Care Institutions for Older Adults (LTCIs), many institutions fail to comply with the Differentiated Regime for Public Procurement (Resolution No. 502/2021) due to structural and operational conditions. This study aimed to investigate Brazilian LTCI managers' understanding of challenges that significantly impact institutional operation and gather suggestions for enhancing RDC No. 502/21., Methods: A cross-sectional, exploratory, and qualitative study was conducted, involving 90 managers or technical supervisors from Brazilian LTCIs. Data were collected using a self-administered Google Forms instrument and analyzed through Thematic Analysis based on the Organizing for Quality (OQ) framework., Results: The most impactful challenges for LTCIs were healthcare, financing, human resources, relationship with oversight bodies, and family members., Discussion: Proposed improvements for RDC No. 502/21 included enhanced professional training, infrastructure revision, increased financial support from the state, realistic oversight/regulations, and tailored monitoring approaches., Conclusion: LTCIs in Brazil face numerous challenges, and the suggested improvements aim to adapt regulations to institutional realities. However, considering the regulations' variability and purposes, further investigation is warranted., (© 2024. The Author(s).)
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- 2024
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17. Counting Sorting Scenarios and Intermediate Genomes for the Rank Distance.
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Zanetti JPP, Oliveira LP, Meidanis J, and Chindelevitch L
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- Sequence Analysis, DNA methods, Models, Genetic, Humans, Algorithms, Genome genetics, Genomics methods
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An important problem in genome comparison is the genome sorting problem, that is, the problem of finding a sequence of basic operations that transforms one genome into another whose length (possibly weighted) equals the distance between them. These sequences are called optimal sorting scenarios. However, there is usually a large number of such scenarios, and a naïve algorithm is very likely to be biased towards a specific type of scenario, impairing its usefulness in real-world applications. One way to go beyond the traditional sorting algorithms is to explore all possible solutions, looking at all the optimal sorting scenarios instead of just an arbitrary one. Another related approach is to analyze all the intermediate genomes, that is, all the genomes that can occur in an optimal sorting scenario. In this article, we show how to enumerate the optimal sorting scenarios and the intermediate genomes between any two given genomes, under the rank distance.
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- 2024
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18. Masticatory performance, self-perception of oral health, oral health-related quality of life and nutritional status of completely edentulous elderly patients submitted to different rehabilitation treatments: A cross-sectional study.
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Jabr CL, Oliveira LP, Pero AC, de Assis Mollo Júnior F, and Filho JNA
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- Aged, Humans, Cross-Sectional Studies, Oral Health, Quality of Life, Nutritional Status, Mouth, Edentulous
- Abstract
Background: The impact of treatments on completely edentulous individuals on masticatory performance (MP), oral health-related quality of life (OHRQoL), nutritional status (NS) and socio-economic profile (SP) is unclear in the literature., Objective: To compare the MP, OHRQoL, NS and SP of totally edentulous elderly users of bimaxillary complete dentures (CD) and users of lower implant-supported fixed complete dentures (IFCD)., Methods: Forty participants were allocated into groups according to rehabilitation treatment (n = 20): bimaxillary CD (G1) and lower IFCD, and upper CD (G2). The evaluation of MP used almonds by the method of sieves. Four questionnaires (Geriatric Oral Health Assessment Index-GOHAI and Oral Health Impact Profile Edent-OHIP-Edent, Brazilian Economic Classification Criteria-ABEP and Mini Nutritional Assessment-MNA) were applied to assess the OHRQoL, SP and NS of the elderly, respectively. After evaluating the statistical assumptions, the Mann-Whitney (α = .05) test was applied to compare the groups regarding MP, OHRQoL, NS and SP. Spearman's correlation (α = .05) was performed to verify the correlation between the MP, the OHRQoL and the NS of the participants., Results: G2 showed better MP (p < .05) in all masticatory cycles, OHRQoL (p < .05) and NS than the G1. However, the participants' self-perception of oral health did not differ between groups (p < .05). A moderate negative correlation was found between MP and OHRQoL for 40 masticatory cycles (r
2 = -0.513; p = .001)., Conclusion: Individuals rehabilitated with IFCD had a higher average monthly family income and achieved superior behaviour in MP and OHRQoL, in addition to lower risks of malnutrition when compared to individuals using bimaxillary CD., (© 2023 John Wiley & Sons Ltd.)- Published
- 2024
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19. ORTHOSTATIC SUPPORT IN PARAPLEGIC AND AMPUTEE PATIENTS: A CONTROLLED TRIAL.
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Hotta GH, Aguiar DP, Alves GCVM, Oliveira LP, de Leopoldino MAM, Fortes JPA, Oliveira FCMB, and Santos FFU
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Introduction: Functional incapacity caused by physical alterations leads to significant limitations in daily activities and has a major impact on the return of people with disabilities to the social space and the workplace. This calls for an evaluation of the long-term influence of the use of a device specially developed for orthostatic posture on the physiological, biomechanical and functional parameters of amputees and spinal cord patients., Objective: The objective was evaluate the effect of postural support device use on function, pain, and biomechanical and cardiologic parameters in spinal cord injury and amputees patients compared to a control group., Methods: The orthostatic device was used by the participants for a period of ten consecutive days, for three cycles of 50 minutes each day, and a 15-day follow-up. Participants were positioned and stabilized using adjustable straps on the shoulders, trunk, and hips. The primary outcome was brief pain inventory. Fifteen participants were included the control group, 15 in the amputee group, and 15 in the spinal cord group., Results: Our results demonstrate that the use of the device allows the orthostatic position of amputees and spinal cord patients evaluated for ten days, leading to improved functionality and pain in the spinal cord and amputee groups compared to the control group. In addition, no changes were observed for secondary outcomes, indicating that the use of the device did not cause harm interference to patients., Conclusion: The long-term use of the orthostatic device is beneficial for improving functionality, reduce pain in amputees and spinal cord injury patients. Level of evidence II; Therapeutic Studies - Investigating the results of treatment ., Competing Interests: The authors declare financial support for the development of this study by Dell Computers, developed at Ceará State University under the project entitled "Technologies for job accessibilization in Brazilian Electronic Industry", through research grants to the authors, allowing data collection and support for the development of the equipment used in the collection. The authors declare that there is no conflict of interest about the judgment and validity of the results presented.
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- 2024
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20. The Brazilian version of the High-Activity Arthroplasty Score: cross-cultural adaptation.
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Oliveira NSP, Cardinot TM, Caputo DDCS, Soares JR, Mathias LNCDC, Batista LA, and Oliveira LP
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- Male, Humans, Adult, Middle Aged, Female, Brazil, Cross-Sectional Studies, Surveys and Questionnaires, Translations, Reproducibility of Results, Cross-Cultural Comparison, Arthroplasty, Replacement, Knee
- Abstract
Background: The High Activity Arthroplasty Score (HAAS) is a self-administered questionnaire, developed in British English, that reliably and validly measures the levels of sports activities in patients following hip and knee arthroplasty surgery., Objective: To cross-culturally adapt the HAAS to Brazilian Portuguese language., Design and Setting: A cross-sectional study was conducted at a public university hospital in Brazil., Methods: The Brazilian version of the HAAS was created through a six-step process: translation, synthesis, committee review, pretesting, back-translation, and submission to developers. The translation step was conducted by two independent bilingual translators, both native speakers of Brazilian Portuguese. The back-translation was performed by an independent translator, a native speaker of British English. To ensure the questionnaire's comprehensibility, 46 volunteers (51% men; average age 34-63) participated in the pre-testing step., Results: The cross-cultural adaptation process necessitated modifications to certain terms and expressions to achieve cultural equivalence with the original HAAS., Conclusion: The HAAS has been translated from English into Brazilian Portuguese and culturally adapted for Brazil. The validation process for HAAS-Brazil is currently underway.
- Published
- 2023
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21. Standardization of the Radiographic Study of the Foot Using the Niza Box.
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Fernandes JVC, Oliveira LP, Fernandes PAA, Niza AC, and Cerqueira ALSL
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Objective This study proposes the Niza box, a device created to reduce interpretive errors among professionals and facilitate the correct positioning of structures by standardizing orthopedic radiography of the foot in anteroposterior, loaded, and Saltzman views. Methods Descriptive study based on material collected at an Orthopedics Ambulatory from a tertiary service in a large Brazilian city. The X-ray device was a Lotus X, model HF 500 M, 500 milliamperes and 125 kilovolts capacity, 100 cm focus-film distance, and 24 × 30 cm radiographic chassis. Device controls were set at 100 mA, 5 mA/sec, and 60 kilovolts, depending on the variable size of the foot. The same team of previously trained radiography technicians performed the tests under the authors' supervision. The chassis were positioned in three specific Niza box spaces per the proposed incidence. Data from 50 images from people between 18 and 70 years old were analyzed. Results Radiographs taken using the proposed device usually had a satisfactory quality, allowing correct identification of the anatomical elements of the foot and ankle and angular reconstruction. Small image variations due to foot size were acceptable and expected, allowing radiograph standardization. Conclusion The Niza box is a good method for minimizing interference and avoiding radiographic interpretation errors, providing quality and agility to the examination, and reducing cost and unnecessary repetitions. It is an innovative, low-cost device made of recyclable and biodegradable material., Competing Interests: Conflito de Interesses Os autores declaram não haver conflito de interesses., (Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
- Published
- 2023
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22. Clinical evaluation of the alcohol use disorders identification test (AUDIT) in Moshi, Tanzania.
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Vissoci JRN, Friedman K, Caruzzo NM, de Oliveira LP, Pauley A, Zadey S, Menegassi V, Sakita F, Boshe J, Staton CA, and Mmbaga B
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- Adult, Humans, Tanzania epidemiology, Reproducibility of Results, Sensitivity and Specificity, Alcohol Drinking epidemiology, Psychometrics, Surveys and Questionnaires, Alcoholism diagnosis, Alcoholism epidemiology
- Abstract
Background: Alcohol use disorder is a major cause of morbidity and mortality in low- and middle-income countries. Alcohol screening using a validated tool is a useful way to capture high-risk patients and engage them in early harm reduction interventions. Our objectives were to 1) evaluate the psychometric evidence the Alcohol Use Disorders Identification Test (AUDIT) and its subscales in the general population of Moshi, Tanzania, and 2) evaluate the usefulness of the tool at predicting alcohol-related harms., Methods: Two hundred and fifty-nine adults living in Moshi, Tanzania were included in the study. We used the AUDIT and its subscales to determine the classification of harmful and hazardous drinking. To analyze the internal structure of AUDIT and the model adequacy we used Confirmatory Factor Analysis (CFA). The reliability of AUDIT was analyzed for Cronbach's alpha, Omega 6 and Composite Reliability. The optimal cut off point for the AUDIT was determined by the receiver operating characteristic (ROC) curve, using the Youden approach to maximize sensitivity and specificity., Results: The median score of the AUDIT was 1 (inter-quartile range: 0-7). The internal structure of the AUDIT showed factor loadings ranging from 0.420 to 0.873. Cronbach's alpha, Omega and Composite Reliability produced values above 0.70. The Average Variance Extracted was 0.530. For the AUDIT, a score of 8 was identified as the ideal cut-off value in our population., Conclusions: This study validates AUDIT in the general population of Moshi and is one of the only studies in Africa to include measures of the internal structure of the AUDIT and its subscales., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Vissoci et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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23. Macroscopic and histological aspects of the pharynx and larynx of the giant anteater (Myrmecophaga tridactyla Linnaeus, 1758).
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de Oliveira E, Nascente EP, Oliveira LP, Neto JMS, de Lima BSG, Cardoso JR, and de Moura VMBD
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- Animals, Vermilingua, Pharynx, Microscopy veterinary, Xenarthra anatomy & histology, Larynx
- Abstract
Giant anteater (Myrmecophaga tridactyla) is an endangered species that resides in much of Latin America, but it has been losing its habitat, especially in the Cerrado biome, where it constantly suffers traumas resulting from fires and roadkill. The anatomical knowledge of structures of the respiratory system is important for a better morphophysiological understanding of the species. Thus, this study aimed to perform the macroscopic and histomorphological description of the pharynx and larynx of the giant anteater. Twelve adult giant anteaters were used, three of them fixed in buffered formalin for further dissection and pharynx and larynx macroscopic analysis of structures. From the other animals, samples of the pharynx and larynx were collected and prepared for histological evaluation under optical microscope. Macroscopically, their pharynx and soft palate are extensive, and the anatomical location of these structures and the larynx differs greatly from that described in other species. The larynx, although more caudal, was similar to that of other animals. Histologically, the epithelium of these regions varied between the pseudostratified ciliated columnar and the non-keratinized stratified squamous epithelium. Laryngeal cartilages were composed of elastic (epiglotti) and hyaline cartilages (arytenoid, cricoid and thyroid cartilage), with an ossification process and glandular clusters around the hyaline cartilage. The distinct anatomical location of the pharynx and larynx of Myrmecophaga tridactyla is the main macroscopic finding of this study, besides the length of the pharynx and soft palate of these animals., (© 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.)
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- 2023
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24. Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review.
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Entessari M and Oliveira LP
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- Humans, Injections, Intra-Articular, Osteoarthritis, Knee therapy, Osteoarthritis, Hip therapy, Mesenchymal Stem Cells, Mesenchymal Stem Cell Transplantation methods
- Abstract
There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections. Only two studies provided information on radiological changes and findings were positive. None of the studies reported major complications. Small series of non-randomized controlled trials completed to date in the use of mesenchymal stem cells for the treatment of hip osteoarthritis reported the procedures to be safe and provide a positive clinical response. Randomized controlled trials must be performed to further confirm mesenchymal stem cells as a treatment option for hip osteoarthritis.
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- 2023
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25. Handgrip force and bite force in dentulous and edentulous individuals.
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Jabr CL, Oliveira LP, Campos LA, Campos JADB, de Oliveira Lima AL, de Assis Mollo Júnior F, and Filho JNA
- Subjects
- Adult, Humans, Female, Bite Force, Denture, Complete, Molar, Hand Strength, Mouth, Edentulous
- Abstract
Background: The literature is unclear about bite force (BF) and handgrip force (HF) in a specific group of different ages and dentate conditions, or even a predictive model for each specific group, using BF and HF as factors., Objective: To establish the correlation between HF and BF in female participants with distinct ages and dentate conditions; also create a predictive model of BF as a function of HF., Methods: Participants were divided into three groups (GI: young natural dentate women, n = 65; GII: adult natural dentate women, n = 67; and GIII: edentulous women users of bimaxillary complete dentures, n = 67) and subjected to an HF measurement test using a digital dynamometer. Subsequently, BF was measured using a digital gnathodynamometer in the molar region. Pearson correlation coefficient (r) and multivariate analysis of variance (α = 0.05) were performed, and simple linear regression was used to obtain a model to predict BF from HF for each group separately (α = 0.05)., Results: All groups presented moderate and strong correlations among the variables (GI: r = 0.838; GII: r = 0.714; GIII: r = 0.646). A significant difference in BF was observed (GI > GII > GIII; p < .05). GIII presented a significantly lower HF than the other groups (p < .05). Besides, three equations predicting BF, using HF, were obtained for use in young/adult dentate and edentulous women., Conclusion: All groups found a positive and significant correlation between BF, HF and groups. HF can be a simple and efficient method for predicting BF using the predictive models developed for women with good health., (© 2023 John Wiley & Sons Ltd.)
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- 2023
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26. Erratum: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study - CORRIGENDUM.
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Arns B, Agani CAJO, Sesin GP, Horvath JDC, Fogazzi DV, Romeiro Silva FK, Costa LS, Pereira AJ, Nassar Junior AP, Cavalcanti BT, Dietrich C, Veiga VC, Catarino DGM, Cheno MY, Biasi A, Ferronatto BR, Bassetti BR, Fernandes CCF, Deutschendorf C, Grion CMC, Vidal CFL, de Oliveira CD, Caser EB, Boschi E, Silva EM, Pizzol FD, Urbano HCA, Silva I, Maia IS, Rego LRM, Oliveira LP, Tavares MB, Dracoulakis MDA, Bainy MP, Golin NA, Tomba PO, Kurtz PMP, Foernges RB, Prestes RM, de Melo RMV, Da Silva RR, Toledo TGP, Lima VP, Fernandes VF, Lovato WJ, and Zavascki AP
- Abstract
[This corrects the article DOI: 10.1017/ash.2023.136.]., (© The Author(s) 2023.)
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- 2023
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27. Clinical and molecular overview of immunotherapeutic approaches for malignant skin melanoma: Past, present and future.
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Venzel R, Campos MCP, de Oliveira LP, Dan Lins RV, Siena ÁDD, Mesquita KT, Moreira Dos Santos TP, Nohata N, Arruda LCM, Sales-Campos H, and Neto MPC
- Subjects
- Humans, Immunotherapy methods, Melanoma, Cutaneous Malignant, Melanoma drug therapy, Skin Neoplasms genetics, Skin Neoplasms therapy
- Abstract
Traditional therapeutic approaches for malignant melanoma, have proved to be limited and/or ineffective, especially with respect to their role in improving patient survival and tumor recurrence. In this regard, immunotherapy has been demonstrated to be a promising therapeutic alternative, boosting antitumor responses through the modulation of cell signaling pathways involved in the effector mechanisms of the immune system, particularly, the so-called "immunological checkpoints". Clinical studies on the efficacy and safety of immunotherapeutic regimens, alone or in combination with other antitumor approaches, have increased dramatically in recent decades, with very encouraging results. Hence, this review will discuss the current immunotherapeutic regimens used to treat malignant melanoma, as well as the molecular and cellular mechanisms involved. In addition, current clinical studies that have investigated the use, efficacy, and adverse events of immunotherapy in melanoma will also be discussed., Competing Interests: Declaration of Competing Interest The authors certify that they have NO conflict of interest, affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. Nijiro Nohata is an employee of MSD K.K., a subsidiary of Merck & Co., Inc. and reports personal fees from MSD K.K. outside this study., (Copyright © 2023 Elsevier B.V. All rights reserved.)
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- 2023
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28. Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1 H -pyrazol-4-yl)-1 H -tetrazole: role of NO/cGMP pathway and calcium channels.
- Author
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de Oliveira LP, Florentino IF, Silva DPB, Pazini F, de Carvalho FS, Sanz G, Vaz BG, da Rocha FF, Fajemiroye JO, Ghedini PC, Lião LM, Menegatti R, Costa EA, and de Oliveira TS
- Subjects
- Mice, Animals, Calcium Channels adverse effects, Calcium Channels metabolism, Carrageenan adverse effects, Anti-Inflammatory Agents pharmacology, Pyrazoles pharmacology, Edema chemically induced, Edema drug therapy, Edema metabolism, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Formaldehyde, Analgesics pharmacology, Vasodilator Agents
- Abstract
Molecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this study presents a new pyrazole derivative 5-(1-(2-fluorophenyl)-1 H -pyrazol-4-yl)-1 H -tetrazole (LQFM039) and evaluated the anti-inflammatory, analgesic, and vasorelaxant effects of this compound as well the mechanisms of action involved in the pharmacological effects. For this, mice were orally treated with LQFM039 (17.5, 35, or 70 mg/kg) prior acetic acid-induced abdominal writhing, formalin, tail flick, and carrageenan-induced paw edema protocols. In addition, vascular reactivity protocols were made with aortic rings contraction with phenylephrine and stimulated with graded concentrations of LQFM039. Abdominal writhing and licking time in both neurogenic and inflammatory phases of formalin were reduced with LQFM039 without altering latency to nociceptive response in the tail flick test. Carrageenan-induced paw edema showed that LQFM039 reduces edema and cell migration. In addition, the mechanism of action of LQFM039 involves NO/cGMP pathway and calcium channels, since this new pyrazole derivate elicited concentration-dependent relaxation attenuated by Nω-nitro-l-arginine methyl ester and 1 H -[1,2,4] oxadiazolo [4,3-alpha]quinoxalin-1-one, and blockade of CaCl
2 -induced contraction. Altogether, our finding suggests anti-inflammatory, antinociceptive, and vasorelaxant effect of this new pyrazole derivative with involvement of NO/cGMP pathway and calcium channels.- Published
- 2023
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29. Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study.
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Arns B, Agani CAJO, Sesin GP, Horvath JDC, Fogazzi DV, Romeiro Silva FK, Costa LS, Pereira AJ, Nassar Junior AP, Cavalcanti BT, Dietrich C, Veiga VC, Catarino DGM, Cheno MY, Biasi A, Ferronatto BR, Bassetti BR, Fernandes CCF, Deutschendorf C, Grion CMC, Vidal CFL, de Oliveira CD, Caser EB, Boschi E, Silva EM, Pizzol FD, Urbano HCA, Silva I, Maia IS, Rego LRM, Oliveira LP, Tavares MB, Dracoulakis MDA, Bainy MP, Golin NA, Tomba PO, Kurtz PMP, Foernges RB, Prestes RM, de Melo RMV, Da Silva RR, Toledo TGP, Lima VP, Fernandes VF, Lovato WJ, and Zavascki AP
- Abstract
Objective: Data are scarce regarding hospital infection control committees and compliance with infection prevention and control (IPC) recommendations in Brazil, a country of continental dimensions. We assessed the main characteristics of infection control committees (ICCs) on healthcare-associated infections (HAIs) in Brazilian hospitals., Methods: This cross-sectional study was conducted in ICCs of public and private hospitals distributed across all Brazilian regions. Data were collected directly from the ICC staff by completing an online questionnaire and during on-site visits through face-to-face interviews., Results: In total, 53 Brazilian hospitals were evaluated from October 2019 to December 2020. All hospitals had implemented the IPC core components in their programs. All centers had protocols for the prevention and control of ventilator-associated pneumonia as well as bloodstream, surgical site, and catheter-associated urinary tract infections. Most hospitals (80%) had no budget specifically allocated to the IPC program; 34% of the laundry staff had received specific IPC training; and only 7.5% of hospitals reported occupational infections in healthcare workers., Conclusions: In this sample, most ICCs complied with the minimum requirements for IPC programs. The main limitation regarding ICCs was the lack of financial support. The findings of this survey support the development of strategic plans to improve IPCs in Brazilian hospitals., Competing Interests: A.P.Z. is a research fellow of the National Council for Scientific and Technological Development, Ministry of Science and Technology, Brazil. A.P.Z. received a research grant from Pfizer and was a member of the advisory board for Spero Therapeutics and Eurofarma. All other authors have no competing interests to declare., (© The Author(s) 2023.)
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- 2023
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30. Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model.
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Guimarães VHD, Lelis DF, Oliveira LP, Borém LMA, Guimarães FAD, Farias LC, de Paula AMB, Guimarães ALS, and Santos SHS
- Subjects
- Animals, Humans, Male, Mice, Diet, High-Fat, Dietary Fats metabolism, Liver metabolism, Obesity etiology, Obesity metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Sugars metabolism, Metabolic Syndrome etiology, Metabolic Syndrome metabolism
- Abstract
Background: Diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases., Objective: The present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice., Methods: Swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed., Results: The main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-α), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity., Conclusions: High-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.
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- 2023
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31. Comparative analysis between cytomorphology and flow cytometry methods in central nervous system infiltration assessment in oncohematological patients.
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Rocha JMC, Murao M, Cancela CSP, de Oliveira LP, Perim LP, Santos JP, and de Oliveira BM
- Abstract
Introduction: Oncohematological patients require the evaluation for possible infiltration of the central nervous system (CNS) by neoplastic cells at diagnosis and/or during the monitoring of the chemotherapeutic treatment. Morphological analysis using conventional microscopy is considered the method of choice to evaluate the cerebrospinal fluid (CSF) samples, despite technical limitations., Objective: This study aimed to compare the performance of the cytomorphology and flow cytometric immunophenotyping (FC) in the detection of CNS infiltration., Method: We evaluated 520 CSF samples collected from 287 oncohematological patients for whom the detection of neoplastic cells was simultaneously requested by cytomorphology and FC., Results: Laboratory analyses revealed 435/520 (83.7%) conclusive results by the two methods evaluated, among which 385 (88.5%) were concordant. Discordance between the methods was observed in 50/435 (11.5%) samples, 45 (90%) being positive by FC. Furthermore, the FC defined the results in 69/72 (95.8%) inconclusive samples by cytomorphology. The positivity of FC was particularly higher among hypocellular samples. Among 431 samples with a cell count of < 5/μL, the FC identified neoplastic cells in 75 (17.4%), while the cytomorphology reported positive results in 26 (6%). Among the samples that presented adequate cell recovery for evaluation by both methods (506/520), the comparative analysis between FC and cytomorphology revealed a Kappa coefficient of 0.45 (CI: 0.37-0.52), interpreted as a moderate agreement., Conclusion: The data showed that the CSF analysis by FC helps in the definition of CNS infiltration by neoplastic cells, particularly in the cases with dubious morphological analysis or in the evaluation of samples with low cellularity., Competing Interests: Conflicts of interest The authors certify that they have no financial interest in the subject matter or materials discussed in this manuscript., (Copyright © 2021 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2023
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32. Low-power laser in increasing doses improve wound healing process in rats.
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de Oliveira LP, de Lima Chagas A, de Souza TR, Araújo IR, de Menezes LB, Miguel MP, and Vulcani VAS
- Subjects
- Rats, Male, Animals, Rats, Wistar, Wound Healing, Collagen pharmacology, Lasers, Skin pathology, Low-Level Light Therapy methods
- Abstract
Low-power laser has been studied and applied as an auxiliary tool in wound healing. However, as it is a therapy with several variables to be controlled, there is great difficulty in establishing protocols and comparing its efficacy. Therefore, the objective of this study was to evaluate the effects of the use of low-power laser in fixed and crescent doses in the healing of skin wounds in rats. Seventy-five male Wistar rats were divided into three groups: G1 with animals that did not receive laser radiation; G2 with animals treated with fixed dose of 3 J/cm
2 laser; G3 with animals treated with laser in increasing doses of 1 J/cm2 , 3 J/cm2 , 5 J/cm2 . Macroscopic and histological analysis were performed. The lowest intensity of PMN was observed in the irradiated groups and G3 had lower intensity of this infiltrate compared to G1 and G2 (p <0.05). On the seventh day of injury, PMN infiltrate decreased in all groups, especially in G3 (p<0.05). It was observed that G2 had more blood vessels than G1 and G3 after 7 days of wound creation (p ˂ 0.05). Collagen quantification showed that laser-treated groups have increased collagen deposition. Different responses in the wound healing process were observed comparing G2 and G3 groups. The fluence of 1J/cm2 presented better results in the anti-inflammatory action than 3 J/cm2 , although G3 presented the greatest amount of total collagen after ten days of treatment., (© 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)- Published
- 2023
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33. A randomised crossover clinical trial of masticatory function in complete denture wearers with conventional and lingualised balanced occlusion.
- Author
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Pereira RP, Rocha COM, Jabr CL, Oliveira LP, and Arioli Filho JN
- Subjects
- Aged, Female, Humans, Male, Dental Occlusion, Dental Occlusion, Balanced, Mastication, Cross-Over Studies, Denture Design, Denture, Complete
- Abstract
Objectives: The purposes of the present study were as follows: (1) to conduct a randomised crossover clinical trial to evaluate masticatory performance in wearers of conventional complete dentures in both arcs with conventional balanced occlusion (CBO) and lingualised balanced occlusion (LBO), using almonds as natural test food chewed for (a) 30 chewing cycles, (b) 40 chewing cycles and (c) until the subject felt ready to swallow and (2) to perform a randomised crossover clinical trial of oral health self-perception through the Geriatric Oral Health Assessment Index (GOHAI) questionnaire., Background: During rehabilitation with full dentures, achieving stability and retention is essential for masticatory performance. A factor that can act is the appropriate occlusal scheme to be used, although the literature is full of discussions as to the most suitable occlusal scheme to be used, being CBO and LBO the most used in complete dentures., Materials and Methods: The clinical trial was conducted with 30 participants (14 males and 16 females; average age 65.8 years). A base of interchangeable posterior teeth in the lower dentures was used, thereby changing the occlusal schemes without needing to make another complete denture. The masticatory tests and GOHAI application were conducted in two sessions: first with each occlusal scheme, and second only after participants did not report discomfort with dentures. The analysis of variance for the mixed repeated-measures test (ANOVA) was used to verify the results (α = 0.05)., Results: The results showed no difference in masticatory performance according to the occlusal scheme (P = .519). The masticatory performance increased with the number of cycles (P < .001) tested, regardless of the type of occlusion scheme, and oral health self-perception was higher after the second masticatory evaluation session (P = .027)., Conclusion: The masticatory performance was similar between the two occlusal schemes, increasing according to the number of chewing cycles. The adaptive period is relevant, regardless of the occlusion scheme, because the time factor was decisive for the improvements noted in the oral health self-perception of the participants (according to the GOHAI results)., (© 2021 Gerodontology Association. John Wiley & Sons Ltd.)
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- 2022
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34. IMPACTO-MR: a Brazilian nationwide platform study to assess infections and multidrug resistance in intensive care units.
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Tomazini BM, Nassar AP Jr, Lisboa TC, Azevedo LCP, Veiga VC, Catarino DGM, Fogazzi DV, Arns B, Piastrelli FT, Dietrich C, Negrelli KL, Jesuíno IA, Reis LFL, Mattos RR, Pinheiro CCG, Luz MN, Spadoni CCDS, Moro EE, Bueno FR, Sampaio CSJC, Silva DP, Baldassare FP, Silva ACA, Veiga T, Barbante L, Lambauer M, Campos VB, Santos E, Santos RHN, Laranjeiras LN, Valeis N, Santucci E, Miranda TA, Patrocínio ACLD, Carvalho A, Sousa EMC, Sousa AHF, Malheiro DT, Bezerra IL, Rodrigues MB, Malicia JC, Silva SSD, Gimenes BDP, Sesin GP, Zavascki AP, Sganzerla D, Medeiros GS, Santos RDRMD, Silva FKR, Cheno MY, Abrahão CF, Oliveira Junior HA, Rocha LL, Nunes Neto PA, Pereira VC, Paciência LEM, Bueno ES, Caser EB, Ribeiro LZ, Fernandes CCF, Garcia JM, Silva VFF, Santos AJD, Machado FR, Souza MA, Ferronato BR, Urbano HCA, Moreira DCA, Souza-Dantas VC, Duarte DM, Coelho J, Figueiredo RC, Foreque F, Romano TG, Cubos D, Spirale VM, Nogueira RS, Maia IS, Zandonai CL, Lovato WJ, Cerantola RB, Toledo TGP, Tomba PO, Almeida JR, Sanches LC, Pierini L, Cunha M, Sousa MT, Azevedo B, Dal-Pizzol F, Damasio DC, Bainy MP, Beduhn DAV, Jatobá JDVN, Moura MTF, Rego LRM, Silva AVD, Oliveira LP, Sodré Filho ES, Santos SSD, Neves IL, Leão VCA, Paes JLL, Silva MCM, Oliveira CD, Santiago RCB, Paranhos JLDR, Wiermann IGDS, Pedroso DFF, Sawada PY, Prestes RM, Nascimento GC, Grion CMC, Carrilho CMDM, Dantas RLAM, Silva EP, Silva ACD, Oliveira SMB, Golin NA, Tregnago R, Lima VP, Silva KGND, Boschi E, Buffon V, Machado AS, Capeletti L, Foernges RB, Carvalho AS, Oliveira Junior LC, Oliveira DC, Silva EM, Ribeiro J, Pereira FC, Salgado FB, Deutschendorf C, Silva CFD, Gobatto ALN, Oliveira CB, Dracoulakis MDA, Alvaia NOS, Souza RM, Araújo LLC, Melo RMV, Passos LCS, Vidal CFL, Rodrigues FLA, Kurtz P, Shinotsuka CR, Tavares MB, Santana IDV, Gavinho LMDS, Nascimento AB, Pereira AJ, and Cavalcanti AB
- Subjects
- Humans, Prospective Studies, Brazil, Drug Resistance, Multiple, Bacterial, Intensive Care Units, Cross Infection epidemiology
- Abstract
Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria., Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform., Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database., Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials.
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- 2022
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35. The Use of Orthostatic Device for 90 Minutes Does Not Change Cardiovascular and Biomechanical Parameters of Patients with Spinal Cord Injury.
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Oliveira LP, da Silva RF, de Leopoldino MAM, Frota SC, de Melo Alves GCV, Fortes JPA, Muniz PHG, Hotta GH, de Mattos Brito Oliveira FC, and Santos-Júnior FFU
- Abstract
Background: Changes in autonomic function are often caused by spinal cord injuries, which lead to limited orthostatic positioning in these patients., Objective: To investigate the cardiovascular and biomechanical parameters during 90 min of postural elevation equipment usage comparing spinal cord injury and healthy subjects., Methods: A device was used that allowed patients with spinal cord injuries to remain in an orthostatic posture for 90 min. During this period, the physiological parameters were measured every 15 min. Cardiovascular parameters (heart rate, oxygen saturation, blood pressure, and autonomic nervous system) and biomechanical parameters of the plantar pressure distribution were evaluated. For blood pressure, heart rate, oxygen saturation, and autonomic nervous system, a two-way analysis of variance was applied. The mixed-effect model was applied to plantar pressure. The significance level was set at p < 0.05 for all statistical analyses., Results: No differences were observed between the groups in systolic blood pressure ( F = 0.07), diastolic blood pressure ( F = 0.14), heart rate ( F = 0.56), and oxygen saturation ( F = 0.23) at any of the time intervals throughout the experiment ( p > 0.05). No statistical difference was observed in the mean plantar pressure values between the groups ( p = 0.35) during the period in which they remained in the orthostatic position., Conclusion: The present study showed the absence of differences between spinal cord injury patients and control participants using the orthostatic device in terms of cardiovascular and biomechanical parameters over 90 min., Competing Interests: The authors declare that there is no conflict of interest about the judgment and validity of the results presented., (Copyright © 2022 Liana Praça Oliveira et al.)
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- 2022
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36. Validation of the Brazilian version of the Hip Sports Activity Scale (HSAS) for patients with femoroacetabular impingement: a cross-sectional study.
- Author
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Mathias LNCDC, Cardinot TM, Sá-Caputo DDC, Freitas JP, Bernardo Filho M, Costa RMP, Oliveira NSP, and Oliveira LP
- Subjects
- Humans, Male, Female, Cross-Sectional Studies, Hip Joint surgery, Brazil, Reproducibility of Results, Treatment Outcome, Femoracetabular Impingement diagnosis, Femoracetabular Impingement surgery
- Abstract
Background: The Hip Sports Activity Scale (HSAS) is a hip-specific instrument for assessing the present levels of physical activity among patients with femoroacetabular impingement (FAI) syndrome. When evaluating treatment outcomes in patients with FAI syndrome, it is necessary to use joint-specific instruments and ones that can evaluate the levels of physical activity in these patients, such as the HSAS-Brazil., Objective: To validate the HSAS-Brazil among a group of physically active patients after arthroscopic treatment of FAI syndrome., Design and Setting: Cross-sectional research of quantitative and qualitative types using data obtained from July 2018 to October 2019., Methods: A total of 58 patients of both genders diagnosed with FAI syndrome and who had undergone hip arthroscopy participated in this research. To establish reliability and validity, patients first answered the Brazilian versions of the 12-Item Short-Form Health Survey (SF-12), Nonarthritic Hip Score (NAHS), and HSAS; after a 48-hour interval, they answered the HSAS-Brazil again., Results: For test-retest reliability, the interclass correlation was 0.908 (P < 0.001). The HSAS-Brazil correlated to the NAHS-Brazil (r = 0.63, P < 0.001), as well as the SF-12 (Physical Health) (r = 0.42, P = 0.001)., Conclusion: The HSAS-Brazil was validated and proved to be a reliable and valid scale to assess sports activity levels in physically active patients with FAI syndrome after arthroscopic treatment.
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- 2022
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37. Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with MRI-negative focal epilepsy.
- Author
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Oliveira LP, Pérez-Enríquez C, Barguilla A, Langohr K, Conesa G, Infante N, Principe A, and Rocamora R
- Subjects
- Humans, Treatment Outcome, Stereotaxic Techniques, Seizures surgery, Electroencephalography methods, Magnetic Resonance Imaging, Retrospective Studies, Electrocoagulation methods, Epilepsies, Partial surgery, Epilepsy surgery, Drug Resistant Epilepsy surgery
- Abstract
Objective: Coupled with stereo-electroencephalography (SEEG), radiofrequency thermocoagulation (RFTC) has emerged as a therapeutic alternative for patients with refractory focal epilepsy, with proven safe but highly variable results across studies. The authors aimed to describe the outcomes and safety of SEEG-RFTC, focusing on patients with MRI-negative epilepsy., Methods: A retrospective observational study was conducted on patients evaluated by SEEG in the authors' center. Of 84 total cases, 55 underwent RFTC, with 31 MRI-negative epilepsies that were ultimately included in the study. The primary outcome was freedom from disabling seizures at last follow-up. Secondary outcomes were reduction in seizure frequency (RFTC response = seizure frequency reduction > 50%), peri-interventional complications, and neuropsychological outcomes. Potential factors influencing post-RFTC outcome were considered by comparing different variables between responders and nonresponders., Results: The mean follow-up period was 30.9 months (range 7.1-69.8 months). Three patients underwent subsequent resection/laser interstitial thermal therapy within the 1st year after RFTC failure. All other patients completed a minimum follow-up period of 1 year. Fourteen patients (45.2%) showed at least a 50% reduction in seizure frequency (responders), and 8 were seizure free (25.8% of the whole cohort). One case showed a permanent complication not directly related to thermolesions. Most patients (76%) showed no significant cognitive decline. Electrically elicited seizures (EESs) were observed in all seizure-free patients and were more frequent in responders (p = 0.038). All patients who were seizure free at the 6-month visit maintained their status during long-term follow-up., Conclusions: SEEG-RFTC is a safe procedure and leads to a good response in many cases of MRI-negative focal epilepsies. One-quarter of the patients were seizure free and almost one-half were responders at the last follow-up. Although these results are still far from those achieved through conventional resection, a nonnegligible proportion of patients may benefit from this one-stage and much less invasive approach. Factors associated with seizure outcome remain to be elucidated; however, responders were significantly more frequent among patients with EESs, and achieving 6 months of seizure freedom appears to predict a good long-term response. In addition, the positive predictive value of RFTC response may be a valuable factor in the decision to proceed to subsequent surgery.
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- 2022
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38. First Report of an Asymptomatic Leishmania (Viannia) shawi Infection Using a Nasal Swab in Amazon, Brazil.
- Author
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Oliveira LP, Nascimento LCS, Santos FS, Takamatsu JLC, Sanchez LRP, Santos WS, and Garcez LM
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- Brazil, Humans, Polymerase Chain Reaction, Leishmania genetics, Leishmania braziliensis genetics, Leishmaniasis, Cutaneous diagnosis
- Abstract
The state of Pará has recorded seven Leishmania species that cause tegumentary leishmaniasis (TL). Leishmania species induce distinct immunological responses from the host and exhibit resistance to Glucantime, the first-line drug treatment for TL in Brazil., Objective: Identify the etiology of TL in an Amazonian city in the state of Pará., Material and Methods: Eleven patients with TL were recruited and nasal swabs, lesion swabs, and skin fragments samples were collected. In the control group (n = 6), only the nasal swabs were collected. Polymerase Chain Reaction (PCR) amplification of the gene region hsp70-234 was performed using the extracted DNA from the samples, from which nine patients with TL and five in the control group were positive. Products were sequenced, mounted in CAP3 software, aligned using MAFFT v.7.221, edited in Geneious software v.8.1.7, and compared and aligned with sequences available in GenBank using the BLAST tool., Results: For patients with TL, six molecular diagnosis at the species level ( L. ( Viannia ) braziliensis (n = 5/9), L. ( Viannia ) shawi (n = 1/9)) and three at the genus level ( Leishmania sp. (n = 3/9)) were obtained. In the control group, four individuals were infected with Leishmania sp. (n = 4/5) and L. (V.) shawi (n = 1/5)., Conclusion: This is the first report of L. (V.) shawi infection in the mucosal secretion of a healthy person in Brazil. Moreover, genetic variants were identified in the haplotypes of L. (V.) braziliensis in the gene sequence hsp70-234.
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- 2022
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39. Bioinformatic analyses to uncover genes involved in trehalose metabolism in the polyploid sugarcane.
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de Oliveira LP, Navarro BV, de Jesus Pereira JP, Lopes AR, Martins MCM, Riaño-Pachón DM, and Buckeridge MS
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- Computational Biology, Glucosyltransferases metabolism, Polyploidy, Trehalase genetics, Saccharum genetics, Saccharum metabolism, Trehalose genetics, Trehalose metabolism
- Abstract
Trehalose-6-phosphate (T6P) is an intermediate of trehalose biosynthesis that plays an essential role in plant metabolism and development. Here, we comprehensively analyzed sequences from enzymes of trehalose metabolism in sugarcane, one of the main crops used for bioenergy production. We identified protein domains, phylogeny, and in silico expression levels for all classes of enzymes. However, post-translational modifications and residues involved in catalysis and substrate binding were analyzed only in trehalose-6-phosphate synthase (TPS) sequences. We retrieved 71 putative full-length TPS, 93 trehalose-6-phosphate phosphatase (TPP), and 3 trehalase (TRE) of sugarcane, showing all their conserved domains, respectively. Putative TPS (Classes I and II) and TPP sugarcane sequences were categorized into well-known groups reported in the literature. We measured the expression levels of the sequences from one sugarcane leaf transcriptomic dataset. Furthermore, TPS Class I has specific N-glycosylation sites inserted in conserved motifs and carries catalytic and binding residues in its TPS domain. Some of these residues are mutated in TPS Class II members, which implies loss of enzyme activity. Our approach retrieved many homo(eo)logous sequences for genes involved in trehalose metabolism, paving the way to discover the role of T6P signaling in sugarcane., (© 2022. The Author(s).)
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- 2022
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40. Management Solutions for the Restructuring of Laboratories Associated to the Sentinel Services for Syphilis and Other STIs.
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Coutinho KD, Valentim RAM, Vieira GV, Sidrim M, Evangelista PHG, and de Oliveira LP
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- Humans, Laboratories, Sexually Transmitted Diseases diagnosis, Syphilis diagnosis
- Abstract
This article aims to develop management solutions to accompany the processes of acquiring and distributing equipment and/or materials needed for the restructuring of associated laboratories to the sentinel services (Sentinel Laboratories) for syphilis and other sexually transmitted infection in the scope of the "Syphilis No!" Project. To this end, we have taken steps to create an overview of the restructuring project for the sentinel laboratories, define the stages of project execution, monitor the implementation of the project, and elaborate a standard operating procedure for the delivery of equipment and/or materials to the sentinel laboratories. Among the results, we highlight: the detailed workflow for the process of public procurement through direct purchases or bidding; the workflow for storage of the equipment and materials; the standard operating procedures (SOP) for contact with the laboratories; and the SOP for delivery of items acquired for the sentinel laboratories., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Coutinho, Valentim, Vieira, Sidrim, Evangelista and Oliveira.)
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- 2022
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41. No effect of combined tele-exercises and nutritional coaching on anthropometric, body composition or exercise capacity outcomes in overweight and obese women: a randomized clinical trial.
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Silva JAD, De Salles Painelli V, Santos IC, Marques DC, Oliveira FM, Oliveira LP, and Branco BHM
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- Body Composition physiology, Body Mass Index, Exercise Tolerance, Female, Humans, Obesity therapy, Quality of Life, Mentoring, Overweight therapy
- Abstract
Introduction: Background: we aimed to investigate the isolated effect of tele-exercises (TE) and their combined effect with nutritional coaching (NC) on health-related parameters of overweight and obese individuals. Methods: forty-one overweight (body mass index ≥ 25 kg/m2) and obese (body mass index ≥ 30 kg/m2) women were randomly assigned to the experimental groups: TE (n = 20) or TE+NC (n = 21). TE was applied 3 days/week in both groups, while TE+NC also received NC 1 day/week. Anthropometric, body composition, and exercise capacity-related outcomes, quality of life, and eating behavior were assessed before and after 8 weeks of the intervention. Results: a significant main time effect (p < 0.01) was detected for flexibility, isometric muscle strength and dynamic muscle endurance, but no main group effect was noted (p > 0.05). On the other hand, neither a significant main time nor group effect (p > 0.05) was detected in the anthropometric and body composition measures, quality of life, or eating behavior. Similarly, no significant between-group difference was observed in the absolute or relative change analysis (all comparisons, p > 0.05). Conclusions: an 8-week TE program enhanced exercise capacity, but did not impact anthropometric or body composition-related outcomes. The combination of NC+TE did not have a clinical advantage in the management of overweight and obesity.
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- 2022
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42. The Brazilian version of the Hip Sports Activity Scale: translation and cross-cultural adaptation.
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Mathias LNCDC, Cardinot TM, Sá-Caputo DDC, Moura-Fernandes MC, Bernardo-Filho M, Soares GLOL, Batista LA, and Oliveira LP
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- Adult, Brazil, Cross-Sectional Studies, Female, Humans, Male, Reproducibility of Results, Surveys and Questionnaires, Young Adult, Cross-Cultural Comparison, Translations
- Abstract
Background: The Hip Sports Activity Scale (HSAS) is a reliable and valid tool for determining the levels of sports activities among patients with femoroacetabular impingement (FAI)., Objective: To translate and cross-culturally adapt the HSAS to the Brazilian Portuguese language., Design and Setting: This was a cross-sectional study conducted at the State University of Rio de Janeiro., Methods: The Brazilian version of the HSAS was developed following a process that comprised six steps: translation, synthesis, back-translation, review by committee, pretesting and submission of documentation to the developers. The translation phase involved three independent bilingual translators whose mother language was Brazilian Portuguese. The back-translation phase involved three independent translators whose mother language was English. In order to verify comprehension of the questionnaire, 30 undergraduate students in physical education (65% men), with mean age 23.2 years (standard deviation = 6.8), participated in the pre-testing phase., Results: During the translation step, some terms and expressions were changed to obtain cultural equivalence to the original HSAS. In the pre-testing phase, each item of the scale showed a comprehension level of 100%., Conclusion: The HSAS was translated from English to the Brazilian Portuguese language and adapted to Brazilian culture. The HSAS validation is ongoing.
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- 2022
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43. Polysaccharide-Based Membrane Biocompatibility Study of Anacardium occidentale L. and Polyvinyl Alcohol after Subcutaneous Implant in Rats.
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Chagas ALD, Oliveira LP, Cruz MV, Melo RM, Miguel MP, Fernandes KF, and Menezes LB
- Abstract
Polymeric membranes are a viable and sustainable option for the biotechnology industry from an economic and environmental point of view. In this study, we evaluated tissue response and tolerance to the implantation of a polymeric membrane prepared with cashew gum polysaccharide (CGP) associated with polyvinyl alcohol (PVA). The objective was to characterize the biocompatibility of the CGP/PVA membrane in vivo. Following the evaluation criteria of the ISO 10993-6 standard, we demonstrated that the CGP/PVA membrane showed moderate tissue reaction, with a non-irritating ISO pattern, a thinner fibrous capsule, and a smaller amount of collagen compared to the positive control group. At 30 and 60 days, the membrane presented a similar amount of mast cells to that observed in the negative control group. The data demonstrate that the CGP/PVA membrane presents biocompatibility in accordance with the ISO 10993-6 standard.
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- 2022
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44. Secondary infections in a cohort of patients with COVID-19 admitted to an intensive care unit: impact of gram-negative bacterial resistance.
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Costa RLD, Lamas CDC, Simvoulidis LFN, Espanha CA, Moreira LPM, Bonancim RAB, Weber JVLA, Ramos MRF, Silva ECF, and Oliveira LP
- Subjects
- Gram-Negative Bacteria, Humans, Intensive Care Units, Pandemics, Retrospective Studies, SARS-CoV-2, COVID-19, Coinfection, Cross Infection epidemiology, Gram-Negative Bacterial Infections epidemiology
- Abstract
Some studies have shown that secondary infections during the COVID-19 pandemic may have contributed to the high mortality. Our objective was to identify the frequency, types and etiology of bacterial infections in patients with COVID-19 admitted to an intensive care unit (ICU) and to evaluate the results of ICU stay, duration of mechanical ventilation (MV) and in-hospital mortality. It was a single-center study with a retrospective cohort of patients admitted consecutively to the ICU for more than 48 h between March and May 2020. Comparisons of groups with and without ICU- acquired infection were performed. A total of 191 patients with laboratory-confirmed COVID-19 were included and 57 patients had 97 secondary infectious events. The most frequent agents were Acinetobacter baumannii (28.9%), Pseudomonas aeruginosa (22.7%) and Klebsiella pneumoniae (14.4%); multi-drug resistance was present in 96% of A. baumannii and in 57% of K. pneumoniae. The most prevalent infection was ventilator-associated pneumonia in 57.9% of patients with bacterial infections, or 17.3% of all COVID-19 patients admitted to the ICU, followed by tracheobronchitis (26.3%). Patients with secondary infections had a longer ICU stay (40.0 vs. 17 days; p < 0.001), as well as a longer duration of MV (24.0 vs 9.0 days; p= 0.003). There were 68 (35.6%) deaths overall, of which 27 (39.7%) patients had bacterial infections. Among the 123 survivors, 30 (24.4%) had a secondary infections (OR 2.041; 95% CI 1.080 - 3.859). A high incidence of secondary infections, mainly caused by gram-negative bacteria has been observed. Secondary infections were associated with longer ICU stay, MV use and higher mortality.
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- 2022
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45. Use of technology for self-care in surgical wound infection surveillance: integrative review.
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Oliveira LP, Lucato ALS, Fernandes DR, Vieira LG, Santos BND, and Silveira RCCP
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- Cross-Sectional Studies, Humans, Surgical Wound Infection epidemiology, Technology, Self Care, Text Messaging
- Abstract
Objectives: to synthesize knowledge about technology for self-care in surgical wound infection surveillance., Methods: integrative review conducted in CINAHL, Embase, LILACS, PubMed, Scopus and Web of Science databases with the descriptors "surgical wound infection" and "self-care", in addition to manual search in the references of the included studies. The selection and evaluation of the methodological quality of the studies and data collection were performed by two independent reviewers; conflicts were resolved by a third reviewer., Results: nine primary studies were included, published between 2011 and 2019. Six are cross-sectional, two are randomized clinical trials, and one is a case report. Mobile, text messaging, and imaging applications, computer software, assessments, and data storage capacity stand out., Conclusions: the technologies identified for self-care in surgical wound infection surveillance were the creation and use of mHealth and the use of health apps on mobile devices. Effective technologies in surveillance of surgical wound infection that enable rapprochement with the healthcare team, encourage a greater number of surgical wound assessments, enhance self-care actions, and decrease patient anxiety. Technology is also a monitored and recorded form of patient care, one of the main axes of infection surveillance.
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- 2022
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46. Factors associated with sarcopenia in institutionalized elderly.
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de Oliveira Neto L, de Oliveira LP, Agrícola PMD, de Oliveira Tavares VD, Gomes IC, Sales MC, and Lima KC
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- Aged, Anthropometry, Cross-Sectional Studies, Humans, Middle Aged, Prevalence, Sarcopenia diagnosis, Sarcopenia epidemiology
- Abstract
Background: The diagnosis of sarcopenia is based on the analysis of strength, functionality and muscle mass. The objective was to verify the factors associated with sarcopenia in institutionalized elderly., Methods: In total, 219 elderly individuals (≥60 years old) living in long-term institutions in Natal/RN were included in the study. After defining the elderly as sarcopenic or non-sarcopenic, anthropometric, biochemical, sociodemographic and health-related were analyzed. The Student t-test and Mann-Whitney test were used to analyze the quantitative, while the chi-square test was used for the qualitative variables. Finally, Poisson regression was used to provide prevalence ratios for those variables that presented differences in the bivariate analyses., Results: Physical capacity and anthropometry were associated with sarcopenia. For each 1 cm of knee height, the elderly presented 2.71% more chance of not having sarcopenia, and eutrophic or overweight individuals (according to BMI) presented 37.71 and 91.81% chances, respectively, of not presenting sarcopenia. Elderly individuals who ambulate have a 30.08% chance of not being considered sarcopenic. In addition, biochemical and anthropometric indicators demonstrated a relationship of sarcopenia with malnutrition., Conclusion: Sarcopenia is associated with a loss of body mass, not only selective muscle mass, and greater physical inability to ambulate., (© The Author(s) 2020. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2021
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47. UCEasy: A software package for automating and simplifying the analysis of ultraconserved elements (UCEs).
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Ribeiro CVR, Oliveira LP, Batista R, and De Sousa M
- Abstract
Background: The use of Ultraconserved Elements (UCEs) as genetic markers in phylogenomics has become popular and has provided promising results. Although UCE data can be easily obtained from targeted enriched sequencing, the protocol for in silico analysis of UCEs consist of the execution of heterogeneous and complex tools, a challenge for scientists without training in bioinformatics. Developing tools with the adoption of best practices in research software can lessen this problem by improving the execution of computational experiments, thus promoting better reproducibility., New Information: We present UCEasy, an easy-to-install and easy-to-use software package with a simple command line interface that facilitates the computational analysis of UCEs from sequencing samples, following the best practices of research software. UCEasy is a wrapper that standardises, automates and simplifies the quality control of raw reads, assembly and extraction and alignment of UCEs, generating at the end a data matrix with different levels of completeness that can be used to infer phylogenetic trees. We demonstrate the functionalities of UCEasy by reproducing the published results of phylogenomic studies of the bird genus Turdus (Aves) and of Adephaga families (Coleoptera) containing genomic datasets to efficiently extract UCEs., (Caio V. R. Ribeiro, Lucas P. Oliveira, Romina Batista, Marcos De Sousa.)
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- 2021
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48. Gut microbiota: A potential therapeutic target for management of diabetic retinopathy?
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Alarcón Yempén RE, Venzel R, Paulino Campos MC, de Oliveira LP, Lins RVD, Pessoni AM, Fanaro GB, de Oliveira Souza A, Calaza KDC, de Brito Alves JL, and Cavalcanti-Neto MP
- Subjects
- Diabetes Mellitus physiopathology, Diabetic Retinopathy therapy, Dysbiosis, Humans, Inflammation physiopathology, Retina metabolism, Diabetic Retinopathy microbiology, Gastrointestinal Microbiome physiology
- Abstract
Diabetic Retinopathy (DR) is one of the main complications of Diabetes Mellitus (DM), drastically impacting individuals of working age over the years, being one of the main causes of blindness in the world. The existing therapies for its treatment consist of measures that aim only to alleviate the existing clinical signs, associated with the microvasculature. These treatments are limited only to the advanced stages and not to the preclinical ones. In response to a treatment with little resolution and limited for many patients with DM, investigations of alternative therapies that make possible the improvement of the glycemic parameters and the quality of life of subjects with DR, become extremely necessary. Recent evidence has shown that deregulation of the microbiota (dysbiosis) can lead to low-grade, local and systemic inflammation, directly impacting the development of DM and its microvascular complications, including DR, in an axis called the intestine-retina. In this regard, the present review seeks to comprehensively describe the biochemical pathways involved in DR as well as the association of the modulation of these mechanisms by the intestinal microbiota, since direct changes in the microbiota can have a drastic impact on various physiological processes. Finally, emphasize the strong potential for modulation of the gut-retina axis, as therapeutic and prophylactic target for the treatment of DR., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
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49. Thromboembolism in Arthroplasty: Compliance to Prophylaxis.
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Viana LMAT, Nogueira IAL, Fontenele AMM, and Oliveira LP
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Objective The present paper aims to identify the profile of compliance to thromboembolism drug prophylaxis in patients undergoing knee or hip arthroplasty at a public hospital. Methods This is a prospective cohort study, carried out from August 2017 to September 2018, with adult patients who were followed-up from admission until the postoperative period. The Morisky Medication Adherence Scale, consisting of eight items, was applied. Compliance was quantified according to the sum of all correct answers as high (8 points), medium (6 to < 8 points), and low compliance (< 6 points). For the present study, subjects with high compliance were referred as highly compliant, whereas those with medium to low compliance were referred as partially compliant. Results The compliance analysis showed that 73.0% of the patients were highly compliant and 27.0% were partially compliant to thromboprophylaxis. The anticoagulant prescribed at hospital discharge was rivaroxaban, a direct factor Xa inhibitor. Compliance was greater in patients who did not require reinforcement in prophylaxis guidance during follow-up; these subjects reported good and excellent acceptance of prophylaxis, although they were on multiple medications at discharge. Conclusion The data analysis allowed us to conclude that the factors that most influenced compliance were the levels of understanding and acceptance of prophylaxis by the patients, the amount of medication used per day by the subject, the cost of the anticoagulant agent, and its potential to cause adverse reactions., Competing Interests: Conflito de Interesses Os autores declaram não haver conflito de interesses., (Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2021
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50. Factors associated with inflamm-aging in institutionalized older people.
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de Oliveira Neto L, Tavares VDO, Agrícola PMD, de Oliveira LP, Sales MC, de Sena-Evangelista KCM, Gomes IC, Galvão-Coelho NL, Pedrosa LFC, and Lima KC
- Subjects
- Aged, Aged, 80 and over, Brazil, Endothelium, Vascular metabolism, Endothelium, Vascular pathology, Female, Homes for the Aged statistics & numerical data, Humans, Male, Middle Aged, Nursing Homes statistics & numerical data, Triglycerides blood, Zinc blood, Aging blood, Geriatric Assessment statistics & numerical data, Interleukin-6 blood, Tumor Necrosis Factor-alpha blood
- Abstract
The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death., (© 2021. The Author(s).)
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- 2021
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