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31 results on '"Olive, Georges"'

10. Isoniazid Dose Adjustment in a Pediatric Population

Author

Rey, Elisabeth, primary, Pons, Gérard, additional, Crémier, Odile, additional, Vauzelle-Kervroëdan, Françoise, additional, Pariente-Khayat, Ann, additional, d'Athis, Philippe, additional, Badoual, Jean, additional, Olive, Georges, additional, and Gendrel, Dominique, additional

Published
1998
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12. Vigabatrin

Author

Rey, Elisabeth, primary, Pons, Gérard, additional, and Olive, Georges, additional

Published
1992
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14. Nitrofurantoin Excretion in Human Milk

Author

Pons, Gérard, primary, Rey, Elisabeth, additional, Richard, Marie-Odile, additional, Vauzelle, Françoise, additional, Francoual, Christine, additional, Moran, Claude, additional, d’Athis, Philippe, additional, Badoual, Jean, additional, and Olive, Georges, additional

Published
1990
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16. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants*.

Author

Tran, Agnès, Rey, Elisabeth, Pons, Gérard, Rousseau, Marina, d'Athis, Philippe, Olive, Georges, Mather, Gary G., Bishop, Frances E., Wurden, Colleen J., Labroo, Rita, Trager, William F., Kunze, Kent L., Thummel, Kenneth E., Vincent, Jean C., Gillardin, Jean-Marie, Lepage, Francis, and Levy, René H.

Published
1997
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19. Maturation of Caffeine NDemethylation in Infancy

Author

PONS, GÉRARD, BLAIS, JEAN-CLAUDE, REY, ELISABETH, PLISSONNIER, MARCELLE, RICHARD, MARIE-ODILE, CARRIER, ODILE, D'ATHIS, PHILIPPE, MORAN, CLAUDE, BADOUAL, JEAN, and OLIVE, GEORGES

Abstract

Four premature neonates and eight infants 1–19 months old received caffeine for apnea. The usual morning oral dose was substituted by 1,3,7 13C-trimethylxanthine (13C-tri CAF) as the citrate salt. Five breath samples were collected the day before (day 1) and the day of 13C-tri CAF administration (day 2). Plasma (after each breath collection) and urine were collected on day 2.13C-CO2exhalation was determined by isotope ratio mass spectrometry. Caffeine and its metabolites were measured using high-pressure liquid chromatography. Assessment of the labeled CO2in the breath revealed no detectable 13C-tri CAF N-demethylation activity in infants before 45 wk postconceptional age. However, demethylation (as urinary metabolites) has been detected before that age. Two-, 4-, and 6-h cumulative excretion of 13C-tri CAF as 13C-CO2increased with postnatal age and correlated with caffeine plasma clearance (r = 0.840, p < 0.01). These results were consistent with those obtained for urinary metabolites. In one infant (19 months old) the cumulative excretion of 13C-CO2while crying was 65 of the value observed during quiet breathing. The measurement of caffeine demethylation using the caffeine CO2breath test is feasible in infants and is a safe and noninvasive method to determine age related changes in P4501-dependent N-demethylase activity.

Published
1988

20. Maturation of Caffeine N-Demethylation in Infancy: A Study Using the 13CO2Breath Test

Author

Pons, Gérard, Blais, Jean-Claude, Rey, Elisabeth, Plissonnier, Marcelle, Richard, Marie-Odile, Carrier, Odile, D'Athis, Philippe, Moran, Claude, Badoual, Jean, and Olive, Georges

Abstract

ABSTRACT: Four premature neonates and eight infants 1–19 months old received caffeine for apnea. The usual morning oral dose was substituted by 1,3,7 13C-trimethylxanthine (13C-tri CAF) as the citrate salt. Five breath samples were collected the day before (day 1) and the day of 13C-tri CAF administration (day 2). Plasma (after each breath collection) and urine were collected on day 2.13C-CO2exhalation was determined by isotope ratio mass spectrometry. Caffeine and its metabolites were measured using high-pressure liquid chromatography. Assessment of the labeled CO2in the breath revealed no detectable 13C-tri CAF N-demethylation activity in infants before 45 wk postconceptional age. However, demethylation (as urinary metabolites) has been detected before that age. Two-, 4-, and 6-h cumulative excretion of 13C-tri CAF as 13C-CO2increased with postnatal age and correlated with caffeine plasma clearance (r = 0.840, p < 0.01). These results were consistent with those obtained for urinary metabolites. In one infant (19 months old) the cumulative excretion of 13C-CO2while crying was 65% of the value observed during quiet breathing. The measurement of caffeine demethylation using the caffeine CO2breath test is feasible in infants and is a safe and noninvasive method to determine age related changes in P4501-dependent N-demethylase activity.

Published
1988
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31. [Analgesic/Antipyretic treatment: ibuprofen or acetaminophen? An update].

Author

Olive G

Subjects
Acetaminophen administration & dosage, Acetaminophen pharmacokinetics, Analgesics therapeutic use, Analgesics, Non-Narcotic therapeutic use, Child, Child, Preschool, Humans, Ibuprofen administration & dosage, Ibuprofen pharmacokinetics, Reye Syndrome drug therapy, Acetaminophen therapeutic use, Ibuprofen therapeutic use
Abstract

Because of the adverse effects associated with aspirin, especially Reye's syndrome in children, practitioners currently use as first line therapy drugs such as ibuprofen or acetaminophen. Their pharmacokinetic characteristics are not quite identical: both are absorbed rapidly and have high bioavailability, however, unlike acetaminophen, ibuprofen is characterized by high plasma protein binding and a limited distribution volume. Both drugs are metabolized essentially in the liver into inactive hydroxylated or glucoronidated metabolites by conjugation but acetaminophen is also transformed into an oxidation compound--normally reduced by glutathione--which, in the case of acute overdosing with depletion of endogenous glutathione stores, may lead to severe hepatotoxicity. Old age and light to moderate renal or hepatic failure do not significantly modify their pharmacokinetic parameters, and thus do not call for dose adjustment. Clinical trials have shown both drugs to have comparable efficacy on pain and fever, with perhaps a slight advantage for ibuprofen. In practice, the choice will depend on the prescription habits of the practitioner, patient's (or parents') preferences and, above all, the pathological context and possible contra-indications.

Published
2006
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