50,084 results on '"Olive, A."'
Search Results
2. Using Gamified Experiments to Tame Complexity: the case of the Schelling Model of Segregation
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Olivé, Aleix Nicolás, Prignano, Luce, Marinelli, Dimitri, and Cozzo, Emanuele
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Physics - Physics and Society - Abstract
This study employs gamified experiments to investigate and refine the Schelling Model of Segregation, a framework that demonstrates how individual preferences can lead to systemic segregation. Using a movement selection algorithm derived from a board game adaptation of the classical Schelling Model, the research examines player strategies aimed at minimizing segregation and maximizing happiness within a controlled environment. Rooted in greedy optimization, the model balances these objectives through a tunable parameter. Empirical data from gameplay is analyzed using Approximate Bayesian Computation, providing insights into player strategies and their alignment with systemic outcomes. The findings highlight the potential of gamification as a tool for engaging with complex social phenomena, enhancing agent-based models, and fostering participatory approaches in the study of emergent behaviors. This dual-layered framework incorporates collective decision-making into micro-macro models, addressing critiques of oversimplification and expanding their utility in educational and policy contexts., Comment: working paper
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- 2025
3. Aspects of Gravitational Portals and Freeze-in during Reheating
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Henrich, Stephen E., Mambrini, Yann, and Olive, Keith A.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We conduct a systematic investigation of freeze-in during reheating while taking care to include both direct and indirect production of dark matter (DM) via gravitational portals and inflaton decay. Direct production of DM can occur via gravitational scattering of the inflaton, while indirect production occurs through scattering in the Standard Model radiation bath. We consider two main contributions to the radiation bath during reheating. The first, which may dominate at the onset of the reheating process, is produced via gravitational scattering of the inflaton. The second (and more standard contribution) comes from inflaton decay. We consider a broad class of DM production rates parameterized as $R_{\chi} \propto T^{n+6}/\Lambda^{n+2}$, and inflaton potentials with a power-law form $V(\phi) \propto \phi^{k}$ about the minimum. We find the relic density produced by freeze-in for each contribution to the Standard Model bath for arbitrary $k$ and $n$, and compare these with the DM density produced gravitationally by inflaton scattering. We find that freeze-in production from the gravitationally-produced radiation bath can exceed that of the conventional decay bath and account for the observed relic density provided that $m_{\chi} > T_{\rm RH}$, with additional $k$- and $n$-dependent constraints. For each freeze-in interaction considered, we also find $m_{\chi}$- and $T_{\rm RH}$-dependent limits on the BSM scale, $\Lambda$, for which gravitational production will exceed ordinary freeze-in production., Comment: 23 pages, 22 figures
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- 2024
4. Carnot-Carath\'{e}odory metrics associated to degenerate elliptic operators in three dimensions
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Korobenko, Lyudmila, Meister, Florian, and Ross, Olive
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Mathematics - Analysis of PDEs ,Mathematics - Metric Geometry - Abstract
This note is a companion paper to arXiv:1608.01630 [math.CA]. Here we generalize some of the geometric results of arXiv:1608.01630 [math.CA] to the case of a $3\times 3$ matrix function $A(x)\approx \mathrm{diag}\{1,f(x_1), g(x_1)\}$. More precisely, we make explicit calculations of the geodesics in the Carnot-Carath\'{e}odory space associated to $A$, and provide estimates on the Lebesgue measures of metric balls centered at the origin in that space.
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- 2024
5. Experiences of Peer Educators in a High School Sexual and Reproductive Health Peer Education Programme in Rwanda
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Aimable Nkurunziza, Germaine Tuyisenge, Michael Habtu, Edward Rwagasore, Erigene Rutayisire, Nadja Van Endert, Justine Bagirisano, Jean Bosco Henri Hitayezu, Olive Tengera, Goele Jans, Beatha Mukarwego, and Assoumpta Yamuragiye
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Background: To contribute to a reduction in teenage pregnancy among in-school adolescents in Rwanda, a sexual and reproductive health peer education programme (SRHPEP) was developed and implemented. Reflecting on the unique characteristics of this newly implemented programme, and understanding peer educators' (PEs) and facilitators' perspectives, can provide insights into the programme's effectiveness and feedback to improve the programme in the future. This study explored the experiences of being a PE in the SRHPEP from the perspectives of PEs and facilitators. Design: Qualitative exploratory design. Setting: Data collection took placed in three public high schools in Rwanda. Method: Three focus group discussions (FGDs) with 22 PEs and 5 in-depth interviews with facilitators were conducted. Results: Thematic analysis identified the benefits of being a PE, including increased competence, enhanced relationships and an improved society's understanding of sexual and reproductive health (SRH). PEs faced challenges, however, including bullying, limited resources and time constraints. A support system (comprising PEs themselves, facilitators and school leadership) and refresher training made being a PE easier. Study participants suggested allocating enough time, training larger numbers of PEs and the provision of contextually relevant educational materials to improve the programme. Conclusion: Findings from this study can be used to guide the development of future ways of strengthening the SRHPEP in schools. They can also help to ensure that PEs are adequately supported in their roles and the needs of the students are met.
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- 2024
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6. Brief Report: Differential Persistence of Primary Reflexes for Children with Autism Spectrum Disorder-- A Systematic Replication
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Olive Healy, Elaine Reilly, Joanna Davies, Victoria Lovett, and Phil Re
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Primary reflexes are highly stereotypical, automatic movements comprising much of the motor repertoire of newborns. The current study examined rates of presence of five primary reflexes (snout, visual rooting, sucking, tactile rooting, and grasp) and variables predictive of their persistence for children with ASD (n = 35), developmental disability (n = 30), and typically developing children matched to participants with ASD on chronological age (n = 30). There was a higher prevalence of snout and visual rooting reflex among children with ASD. These data suggest that the persistence of primary reflexes holds promise as a biomarker for autism spectrum disorder (ASD).
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- 2024
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7. Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure
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Schwartz, Lilith A, Norman, Jordan O, Hasan, Sharika, Adamek, Olive E, Dzuong, Elisa, Lowenstein, Jasmine C, Yost, Olivia G, Sankaran, Banumathi, and McLaughlin, Krystle J
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Biochemistry and Cell Biology ,Biological Sciences ,Autoimmune Disease ,Digestive Diseases ,Microbiome ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Oral and gastrointestinal ,Bacteroides ,Crystallography ,X-Ray ,Gastrointestinal Microbiome ,Amidohydrolases ,Humans ,Models ,Molecular ,Bacterial Proteins ,Catalytic Domain ,Protein Conformation ,Medicinal and Biomolecular Chemistry ,Medical Biochemistry and Metabolomics ,Biochemistry & Molecular Biology ,Biochemistry and cell biology ,Medical biochemistry and metabolomics ,Medicinal and biomolecular chemistry - Abstract
Bacteroides are often the most abundant, commensal species in the gut microbiome of industrialized human populations. One of the most commonly detected species is Bacteroides ovatus. It has been linked to benefits like the suppression of intestinal inflammation but is also correlated with some autoimmune disorders, for example irritable bowel disorder (IBD). Bacterial cell surface carbohydrates, like capsular polysaccharides (CPS), may play a role in modulating these varied host interactions. Recent studies have begun to explore the diversity of CPS loci in Bacteroides; however, there is still much unknown. Here, we present structural and functional characterization of a putative polysaccharide deacetylase from Bacteroides ovatus (BoPDA) encoded in a CPS biosynthetic locus. We solved four high resolution crystal structures (1.36-1.56 Å) of the enzyme bound to divalent cations Co2+, Ni2+, Cu2+, or Zn2+ and performed carbohydrate binding and deacetylase activity assays. Structural analysis of BoPDA revealed an atypical domain architecture that is unique to this enzyme, with a carbohydrate esterase 4 (CE4) superfamily catalytic domain inserted into a carbohydrate binding module (CBM). Additionally, BoPDA lacks the canonical CE4 His-His-Asp metal binding motif and our structures show it utilizes a noncanonical His-Asp dyad to bind metal ions. BoPDA is the first protein involved in CPS biosynthesis from B. ovatus to be characterized, furthering our understanding of significant biosynthetic processes in this medically relevant gut microbe.
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- 2025
8. A descriptive summary of the WHO availability assessments of medical abortion medicines in eight African countries.
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Grossman, Amy, Prata, Ndola, Jones, Sarah, Läser, Laurence, Ganatra, Bela, Lavelanet, Antonella, Williams, Natalie, Asmani, Chilanga, Elamin, Hayfa, Ouedraogo, Leopold, Maribe, Lucy, Gbenou, Dina, Hien, Yelmali, Dadjoari, Moussa, Dao, Fousséni, Adame Gbanzi, Mariette, Mulunda Kanke, Robert, Biayi Kanumpepa, Franck, Dlamini, Dudu, Mefane, Grace, Bantiewalu, Sirak, Brantuo, Mary, Sentumbwe-Mugisa, Olive, Mugahi, Richard, Ojo, Olumuyiwa, Aderoba, Adeniyi, and Rehnström Loi, Ulrika
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Abortion ,Botswana ,Burkina Faso ,Central African Republic ,Combi-pack ,Democratic Republic of the Congo ,Eswatini ,Lesotho ,Medical abortion ,Mifepristone ,Misoprostol ,Namibia ,Uganda ,Humans ,Abortion ,Induced ,Female ,Health Services Accessibility ,Africa ,Pregnancy ,World Health Organization ,Abortifacient Agents ,Misoprostol ,Mifepristone - Abstract
BACKGROUND: The use of medical abortion using either a combination of mifepristone and misoprostol, or misoprostol alone has contributed to increased safety and decreased mortality and morbidity. The availability of quality medical abortion medicines is an essential component in the provision of quality abortion care. Understanding the factors that influence the availability of medical abortion medicines is important to help in-country policymakers, program planners, and providers improve availability and use of medical abortion. METHODS: Using a national assessment protocol and an availability framework, we assessed the availability of medical abortion medicines across five elements (Registration & Quality Assurance, Policy & Financing, Procurement & Distribution, Provider Knowledge, and End-user Knowledge) in eight countries: Botswana, Burkina Faso, Central African Republic, Democratic Republic of the Congo, Eswatini, Lesotho, Namibia and Uganda between November 2020 and November 2021. The assessment included an online desk review and virtual or telephone-based key informant interviews. RESULTS: Registration of medical abortion medicines-misoprostol or co-packaged mifepristone and misoprostol products (combi-pack)-was established in all countries, except the Central African Republic. In Lesotho and Eswatini, the national regulatory agency is still in development and importation of Cytotec™ misoprostol is permitted for off-label use in obstetrics/gynecology. Misoprostol was included in all countries essential medicines lists, except Botswana. Burkina Faso and Democratic Republic of the Congo also include mifepristone on their essential medicines list and medical abortion regimens in national abortion care service and delivery guidelines. Additionally, guidelines clarified health worker roles in the provision of abortion care specific to the legal context of each country and permitted task-shifting of abortion service provision. Where guidelines did not exist, medical abortion medicines and their use were not well integrated into the public health care system. Community awareness activities on abortion rights and services have been limited in scope across the countries assessed, however, end-users awareness of misoprostol as a medical abortion medicine was reported. CONCLUSION: The national landscape assessments identified several cross-cutting opportunities to improve availability of medical abortion medicines, including importing quality-assured medical abortion medicines; developing nationally approved abortion service and delivery guidelines that optimize healthcare worker roles; and expanding communication strategies to reach end-users and pharmacists.
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- 2024
9. Asymmetric Opinion Formation of Emotional Eccitable Agents
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Ferri, Irene, Cozzo, Emanuele, Nicolas-Olive, Aleix, Diaz-Guilera, Albert, and Prignano, Luce
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Physics - Physics and Society ,91C20, 91D30 - Abstract
The bounded confidence model represents a widely adopted framework for modeling opinion dynamics wherein actors have a continuous-valued opinion and interact and approach their positions in the opinion space only if their opinions are within a specified confidence threshold. Here, we propose a novel framework where the confidence bound is determined by a decreasing function of their emotional arousal, an additional independent variable distinct from the opinion value. Additionally, our framework accounts for agents' ability to broadcast messages, with interactions influencing the timing of each other's message emissions. Our findings underscore the significant role of synchronization in shaping consensus formation. Furthermore, we demonstrate that variable confidence intervals alter the impact of step length when navigating the opinion space, leading to deviations from observations in the traditional Deffuant model., Comment: 21 pages, 18 figures. This paper extends the bounded confidence model by incorporating emotion-driven bound tuning, multibody interactions, and synchronization dynamics. Previously submitted to the Conference on Complex Systems 2021 and 2022, and Complex Networks 2021
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- 2024
10. Anisotropic transverse magnetoresistance temperature dependence in Mn3Ga Weyl semimetal with chiral anomaly
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Cota-Martínez, I. M., Antón, R. López, Garay-Tapia, A. M., Matutes-Aquino, J. A., Santillán-Rodríguez, C. R., Saénz-Hernández, R. J., Gutiérrez-Pérez, R. M., Holguín-Momaca, J. T., Ross, C. A., and Olive-Méndez, Sion F.
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Condensed Matter - Materials Science - Abstract
Hexagonal antiferromagnetic D019-Mn3X (X = Sn, Ge, Ga) compounds, with a non-collinear Kagome spin structure, are Weyl semimetals exhibiting novel topological transport properties. The longitudinal magnetoresistance of c-oriented epitaxial Ru/Mn3Ga thin films exhibits a positive quadratic dependence on magnetic field over a wide range of temperatures. Here we describe the transverse magnetoresistance, with the field in the out-of-plane direction, for c-oriented epitaxial GaN (0001)/Mn3Ga films. There is a transition from a negative linear to a positive quadratic dependence on magnetic field in the temperature range from 200 K to 300 K. The electrical resistivity shows a metallic to semiconductor transition at 230 K. By applying the electric field along two perpendicular in-plane directions we find asymmetry in the magnetoresistance curves due to self-spin polarized currents created through magnetic octupole clusters. First principles calculations confirmed the metallic to semiconductor transition corresponds to reordering the spin structure to a higher symmetry configuration., Comment: 16 pages, 4 figures, to be submitted to Nano Letters
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- 2024
11. $R^2$--Inflation Derived from 4d Strings, the Role of the Dilaton, and Turning the Swampland into a Mirage
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Antoniadis, Ignatios, Nanopoulos, Dimitri V., and Olive, Keith A.
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High Energy Physics - Theory - Abstract
Based on a previously derived superstring model possessing a cosmological sector that mimics Starobinsky inflation, we analyze several questions addressed in the recent literature: the generation of an effective $R^2$-term, the stability of the sgoldstino , the modular symmetry of the inflaton potential and the large distance swampland conjecture. We first show that the presence of the string dilaton stabilizes the sgoldstino direction in the supersymmetric case and no modification of the K\"ahler potential is needed. This is a generic property of a large class of Starobinsky type models within the framework of no-scale supergravity. We then present an explicit example of a string derived inflaton potential where the large values of the inflaton field during inflation imply a decompactification of two extra dimensions, while the scale of inflation is generated by higher order $\alpha'$-corrections via expectation values that cancel the D-term of an anomalous $U(1)$ symmetry and break the modular symmetry of the scalar potential. As a result, the scale of inflation is much lower than the compactification scale which at the end of inflation is fixed at the free-fermionic self-dual point at an (approximate) supersymmetric minimum., Comment: 24 pages
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- 2024
12. OATH: Efficient and Flexible Zero-Knowledge Proofs of End-to-End ML Fairness
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Franzese, Olive, Shamsabadi, Ali Shahin, and Haddadi, Hamed
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Computer Science - Computers and Society ,Computer Science - Machine Learning - Abstract
Though there is much interest in fair AI systems, the problem of fairness noncompliance -- which concerns whether fair models are used in practice -- has received lesser attention. Zero-Knowledge Proofs of Fairness (ZKPoF) address fairness noncompliance by allowing a service provider to verify to external parties that their model serves diverse demographics equitably, with guaranteed confidentiality over proprietary model parameters and data. They have great potential for building public trust and effective AI regulation, but no previous techniques for ZKPoF are fit for real-world deployment. We present OATH, the first ZKPoF framework that is (i) deployably efficient with client-facing communication comparable to in-the-clear ML as a Service query answering, and an offline audit phase that verifies an asymptotically constant quantity of answered queries, (ii) deployably flexible with modularity for any score-based classifier given a zero-knowledge proof of correct inference, (iii) deployably secure with an end-to-end security model that guarantees confidentiality and fairness across training, inference, and audits. We show that OATH obtains strong robustness against malicious adversaries at concretely efficient parameter settings. Notably, OATH provides a 1343x improvement to runtime over previous work for neural network ZKPoF, and scales up to much larger models -- even DNNs with tens of millions of parameters.
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- 2024
13. The Role of the Curvaton Post-Planck
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Choi, Gongjun, Ke, Wenqi, and Olive, Keith A.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The expected improvements in the precision of inflationary physics observables including the scalar spectral index $n_{s}$ and the tensor-to-scalar ratio $r$ will reveal more than just the viability of a particular model of inflation. In the presence of a curvaton field $\chi$, supposedly dead models of inflation can be resurrected as these observables are affected by curvaton perturbations. For currently successful models, improved constraints will enable us to constrain the properties of extra decaying scalar degrees of freedom produced during inflation. In this work, we demonstrate these diverse uses of a curvaton field with the most recent constraints on ($n_{s},r$) and two exemplary inflation models, the Starobinsky model, and a model of new inflation. Our analysis invokes three free parameters: the curvaton mass $m_{\chi}$, its decay rate $\Gamma_{\chi}$ the reheating temperature $T_{\rm RH}$ produced by inflaton decays. We systematically analyze possible post-inflationary era scenarios of a curvaton field. By projecting the most recent CMB data on ($n_{s},r$) into this parameter space, we can either set constraints on the curvaton parameters from successful models of inflation (so that the success is not spoiled) or determine the parameters which are able to save a model for which $n_{s}$ is predicted to be below the experimental data. We emphasize that the initial value of $\langle \chi^2 \rangle \propto H^4/m_\chi^2$ produced during inflation is determined from a stochastic approach and thus not a free parameter in our analysis. We also investigate the production of local non-Gaussianity $f_{NL}^{(\rm loc)}$ and apply current CMB constraints to the parameter space. Intriguingly, we find that a large value of $f_{NL}^{(\rm loc)}$ of $\mathcal{O}(1)$ can be produced for both of the two representative inflation models., Comment: 14 pages, 4 figures
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- 2024
14. Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium (MarkVCID)
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Duke University, Johns Hopkins University, University of New Mexico, University of Southern California, University of Kentucky, Rush University Medical Center, University of Maryland, Baltimore, University of California, San Francisco, University of California, Los Angeles, University of California, Davis, University of Texas, The University of Texas Health Science Center at San Antonio, The University of Texas Health Science Center, Houston, Mayo Clinic, University of Mississippi Medical Center, Washington University School of Medicine, Olive View-UCLA Education & Research Institute, and Steven M. Greenberg, MD,PhD, Director, Hemorrhagic Stroke Research
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- 2025
15. Youth Partners in Care for Suicide Prevention (YPIC-SP)
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Duke University, Brown University, University of Utah, Olive View-UCLA Education & Research Institute, RAND, Patient-Centered Outcomes Research Institute, and Joan Asarnow, Professor of Psychiatry & Biboehavioral Sciences
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- 2024
16. Collaboration Leading to Addiction Treatment and Recovery From Other Stresses (CLARO)
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University of New Mexico, Boston Medical Center, First Choice Community Healthcare, Hidalgo Medical Services, National Institute of Mental Health (NIMH), Stanford University, University of Pittsburgh, Saint John's Cancer Institute, Olive View-UCLA Education & Research Institute, and Katherine Watkins, Senior Physician Policy Researcher
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- 2024
17. Non-universal SUSY models, $g_\mu-2$, $m_H$ and dark matter
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Ellis, John, Olive, Keith A., and Spanos, Vassilis C.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Experiment ,High Energy Physics - Theory - Abstract
We study the anomalous magnetic moment of the muon, $g_\mu - 2 \equiv 2 a_\mu$, in the context of supersymmetric models beyond the CMSSM, where the unification of either the gaugino masses $M_{1,2,3}$ or sfermion and Higgs masses is relaxed, taking into account the measured mass of the Higgs boson, $m_H$, the cosmological dark matter density and the direct detection rate. We find that the model with non-unified gaugino masses can make a contribution $\Delta a_\mu\sim 20 \times 10^{-10}$ to the anomalous magnetic moment of the muon, for example if $M_{1,2} \sim 600$ GeV and $M_3\sim 8$ TeV. The model with non-universal sfermion and Higgs masses can provide even larger $\Delta a_\mu \sim 24 \times 10^{-10}$ if the sfermion masses for the first and the second generations are $ \sim 400 $ GeV and that of the third is $ \sim 8 $ TeV. We discuss the prospects for collider searches for supersymmetric particles in specific benchmark scenarios illustrating these possibilities, focusing in particular on the prospects for detecting the lighter smuon and the lightest neutralino., Comment: 34 pages, 17 figures
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- 2024
18. Inflaton Production of Scalar Dark Matter through Fluctuations and Scattering
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Choi, Gongjun, Garcia, Marcos A. G., Ke, Wenqi, Mambrini, Yann, Olive, Keith A., and Verner, Sarunas
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
We study the effects on particle production of a Planck-suppressed coupling between the inflaton and a scalar dark matter candidate, $\chi$. In the absence of this coupling, the dominant source for the relic density of $\chi$ is the long wavelength modes produced from the scalar field fluctuations during inflation. In this case, there are strong constraints on the mass of the scalar and the reheating temperature after inflation from the present-day relic density of $\chi$ (assuming $\chi$ is stable). When a coupling $\sigma \phi^2 \chi^2$ is introduced, with $\sigma = {\tilde \sigma} m_\phi^2/ M_P^2 \sim 10^{-10} {\tilde \sigma}$, where $m_\phi$ is the inflaton mass, the allowed parameter space begins to open up considerably even for ${\tilde \sigma}$ as small as $\gtrsim 10^{-7}$. For ${\tilde \sigma} \gtrsim \frac{9}{16}$, particle production is dominated by the scattering of the inflaton condensate, either through single graviton exchange or the contact interaction between $\phi$ and $\chi$. In this regime, the range of allowed masses and reheating temperatures is maximal. For $0.004 < {\tilde \sigma} < 50$, constraints from isocurvature fluctuations are satisfied, and the production from parametric resonance can be neglected., Comment: 13 pages, 4 Figures
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- 2024
19. Building Analysis and Models to Enhance Naval Infrastructure Resilience
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Oliveros, Olive
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- 2024
20. A neoantigen vaccine generates antitumour immunity in renal cell carcinoma
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Braun, David A., Moranzoni, Giorgia, Chea, Vipheaviny, McGregor, Bradley A., Blass, Eryn, Tu, Chloe R., Vanasse, Allison P., Forman, Cleo, Forman, Juliet, Afeyan, Alexander B., Schindler, Nicholas R., Liu, Yiwen, Li, Shuqiang, Southard, Jackson, Chang, Steven L., Hirsch, Michelle S., LeBoeuf, Nicole R., Olive, Oriol, Mehndiratta, Ambica, Greenslade, Haley, Shetty, Keerthi, Klaeger, Susan, Sarkizova, Siranush, Pedersen, Christina B., Mossanen, Matthew, Carulli, Isabel, Tarren, Anna, Duke-Cohan, Joseph, Howard, Alexis A., Iorgulescu, J. Bryan, Shim, Bohoon, Simon, Jeremy M., Signoretti, Sabina, Aster, Jon C., Elagina, Liudmila, Carr, Steven A., Leshchiner, Ignaty, Getz, Gad, Gabriel, Stacey, Hacohen, Nir, Olsen, Lars R., Oliveira, Giacomo, Neuberg, Donna S., Livak, Kenneth J., Shukla, Sachet A., Fritsch, Edward F., Wu, Catherine J., Keskin, Derin B., Ott, Patrick A., and Choueiri, Toni K.
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- 2025
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21. Advancing Global Landslide Segmentation: A Coupled Multispectral Attention and Data Augmentation Approach Using the Novel MRGSLD Dataset
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Emani, Ghislain Franck, Xu, Weiya, Guédé, Kanon Guédet, Nattabi, Firdawus Ssemugga, and Yemele, Olive Mekontchou
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- 2025
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22. Young Adults with Type 1 Diabetes’ Clinical Outcomes and Satisfaction Related to the Use of Videoconferencing for Type 1 Diabetes Healthcare: A Narrative Review
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James, Steven, Saiyed, Mahira, James, Olive, Gokalani, Rutul, Paterson, Megan, Mehta, Kiran Mejia, Klatman, Emma, Craft, Judy, and Mehta, Roopa
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- 2025
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23. Faith in Crisis: An Exploratory Qualitative Study of the Role of Faith Community Leaders and Faith Community Nurses in Balancing Public Health Guidance and Spiritual Leadership During COVID-19 in the United States
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Yang, Cindy and Olive, Kenneth
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- 2024
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24. The Effect of Combination of Mediterranean Diet and Oleocanthal in Patients with Mild Cognitive Impairment (MeDi-SUPOL)
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Greek Alzheimer's Association and Related Disorders, University of Glasgow, World Olive Center for Health, and Magda Tsolaki, Emeritus Professor Tsolaki Magdalini
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- 2024
25. Inflaton decay in No-Scale Supergravity and Starobinsky-like models
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Ema, Yohei, Garcia, Marcos A. G., Ke, Wenqi, Olive, Keith A., and Verner, Sarunas
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
We consider the decay of the inflaton in Starobinsky-like models arising from either an $R+R^2$ theory of gravity or $N=1$ no-scale supergravity models. If Standard Model matter is simply introduced to the $R + R^2$ theory, the inflaton (which appears when the theory is conformally transformed to the Einstein frame) couples to matter predominantly in Standard Model Higgs kinetic terms. This will typically lead to a reheating temperature of $\sim 3 \times 10^9$~GeV. However, if the Standard Model Higgs is conformally coupled to curvature, the decay rate may be suppressed and vanishes for a conformal coupling $\xi = 1/6$. Nevertheless, inflaton decays through the conformal anomaly leading to a reheating temperature of order $10^8$~GeV. The Starobinsky potential may also arise in no-scale supergravity. In this case, the inflaton decays if there is a direct coupling of the inflaton to matter in the superpotential or to gauge fields through the gauge kinetic function. We also discuss the relation between the theories and demonstrate the correspondence between the no-scale models and the conformally coupled $R+R^2$ theory (with $\xi = 1/6$)., Comment: 21 pages, 2 figures, Contribution to Universe Special Issue: Particle Physics and Cosmology: A Themed Issue in Honour of Professor Dimitri Nanopoulos
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- 2024
26. The minimal control time for the exact controllability by internal controls of 1D linear hyperbolic balance laws
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Hu, Long and Olive, Guillaume
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Mathematics - Optimization and Control ,35L40, 93B05 - Abstract
In this article we study the internal controllability of 1D linear hyperbolic balance laws when the number of controls is equal to the number of state variables. The controls are supported in space in an arbitrary open subset. Our main result is a complete characterization of the minimal control time for the exact controllability property.
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- 2024
27. Dark Matter Line Searches with the Cherenkov Telescope Array
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Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Ruiter, A. J., Rulten, C. B., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sánchez-Conde, M., Sandaker, H., Sangiorgi, P., Sano, H., Santander, M., Santos-Lima, R., Sapienza, V., Šarić, T., Sarkar, A., Sarkar, S., Saturni, F. G., Savarese, S., Scherer, A., Schiavone, F., Schipani, P., Schleicher, B., Schovanek, P., Schubert, J. L., Schwanke, U., Arroyo, M. Seglar, Seitenzahl, I. R., Sergijenko, O., Servillat, M., Siegert, T., Siejkowski, H., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Hatlen, E. Sæther, Stolarczyk, T., Strišković, J., Suda, Y., Świerk, P., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tavernier, T., Tejedor, L. A., Terauchi, K., Teshima, M., Testa, V., Tian, W. W., Tibaldo, L., Tibolla, O., Peixoto, C. J. Todero, Torradeflot, F., Torres, D. F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., and Zuriaga-Puig, J.
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High Energy Physics - Phenomenology ,Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
Monochromatic gamma-ray signals constitute a potential smoking gun signature for annihilating or decaying dark matter particles that could relatively easily be distinguished from astrophysical or instrumental backgrounds. We provide an updated assessment of the sensitivity of the Cherenkov Telescope Array (CTA) to such signals, based on observations of the Galactic centre region as well as of selected dwarf spheroidal galaxies. We find that current limits and detection prospects for dark matter masses above 300 GeV will be significantly improved, by up to an order of magnitude in the multi-TeV range. This demonstrates that CTA will set a new standard for gamma-ray astronomy also in this respect, as the world's largest and most sensitive high-energy gamma-ray observatory, in particular due to its exquisite energy resolution at TeV energies and the adopted observational strategy focussing on regions with large dark matter densities. Throughout our analysis, we use up-to-date instrument response functions, and we thoroughly model the effect of instrumental systematic uncertainties in our statistical treatment. We further present results for other potential signatures with sharp spectral features, e.g.~box-shaped spectra, that would likewise very clearly point to a particle dark matter origin., Comment: 44 pages JCAP style (excluding author list and references), 19 figures; minor changes to match published version
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- 2024
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28. In the Absence of Sound
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Howden, Olive
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Pure silence is not simply the absence of sound. It is the piercing memory of it, a raging void that howls with mimicries. Even when I cannot hear, my world is never fully quiet. “In the Absence of Sound” is a collection of creative short stories, poems, vignettes, and images centered around my experiences as a deaf individual with cochlear implants. My hearing is dependent on technology, but not even the most cutting-edge scientific advances can replace natural sound. I have lived my life not quite hearing the entire conversation, relying on lipreading and other aids to compensate where my hearing falls short. Through this project, I explored and reflected on the struggle of being surrounded by conversation, while comprehension is just out of reach. It can be lonely to be caught between the hearing and deaf worlds, even as they cut and bleed into one another. But the hard-of-hearing community is vast, and more often I find myself encountering others with similar experiences. With the support and understanding of my friends and family, I appreciate my hearing more every day. Sounds that were once artificial and tinny are now beautiful melodies. I hope this project is a glimpse into the deaf experience.
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- 2024
29. 'We've Been Forgotten': First-Hand Perspectives on Teacher Leaders and Teacher Leadership in Urban Schools
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Meredith L. Wronowski, Bryan A. VanGronigen, Wesley L.C. Henry, and James L. Olive
- Abstract
The use of teacher leadership in PK-12 education has experienced a resurgence since the late 1990s as school leadership models have evolved to include the engagement of diverse stakeholders in school and district leadership processes aimed at improvement efforts. Despite this resurgence, there remain several barriers to understanding the nature of the work in which teacher leaders engage and the contributions that they make. This grounded theory study examined teacher perceptions of teacher leadership, the types of work in which teacher leaders do and should engage, the boundaries of that work, and barriers to teacher leadership. Leveraging interviews with teachers in a large urban school district, we found that teachers function in many domains of work and are eager for pathways to leverage their expertise, but some faced a lack of access to their school's leadership and management space. We conclude by discussing the implications from our findings for school- and district-level leaders, local and state policymakers, and educational leadership preparation programs.
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- 2024
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30. Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice
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Mittal, Ekansh, Prasad, G. V. R. Krishna, Upadhyay, Sandeep, Sadadiwala, Jully, Olive, Andrew J., Yang, Guozhe, Sassetti, Christopher M., and Philips, Jennifer A.
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- 2024
- Full Text
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31. The Impact of Combined Within- and Across-Activity Choice on the Indices of Happiness and Unhappiness of Autistic Children
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Ramey, Devon, Healy, Olive, and McEnaney, Emma
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- 2024
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32. What are the Factors Influencing Service Provider Response to Working with Families Affected by Intimate Partner Violence and Abuse? A Qualitative Systematic Review of the Literature
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Mayrhofer, Andrea M., Alderson, Hayley, Sarma, Kausiki, Jackson, Caroline, Olive, Philippa, Toma, Madalina, Mansuri, Nushra, Waterfield, Amy, Crossen, Sharon, Parker, Deborah, Forder, Julien, Kaner, Eileen, Miller, Robin, Gabbay, Mark, Akeju, Dorcas, and McGovern, Ruth
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- 2024
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33. Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials
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Maduka, Chima V., Schmitter-Sánchez, Axel D., Makela, Ashley V., Ural, Evran, Stivers, Katlin B., Pope, Hunter, Kuhnert, Maxwell M., Habeeb, Oluwatosin M., Tundo, Anthony, Alhaj, Mohammed, Kiselev, Artem, Chen, Shoue, Donneys, Alexis, Winton, Wade P., Stauff, Jenelle, Scott, Peter J. H., Olive, Andrew J., Hankenson, Kurt D., Narayan, Ramani, Park, Sangbum, Elisseeff, Jennifer H., and Contag, Christopher H.
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- 2024
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34. Eco-toxicological impacts of industrial wastewater and the role of bio-electrochemical systems (BES) in remediation: a review
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Usman, Muhammad, Zhao, Zhenhua, Yemele, Olive Mekontchou, Ibrahim, Muhammad, Raza, Waleed, Rehman, Zia Ur, Omer, Abduelrahman Adam, Talpur, Mir Moazzam Ali, Jeridi, Mouna, Ashraf, Ghulam Abbas, and Danjaji, Hafsat Alhassan
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- 2024
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35. Racialized Immigrants’ Encounters of Barriers and Facilitators in Seeking Mental Healthcare Services in Ontario, Canada
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Salam, Zoha, Carranza, Mirna, Newbold, Bruce, Wahoush, Olive, and Joseph, Ameil
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- 2024
- Full Text
- View/download PDF
36. On the enumeration of signatures of XOR-CNF's
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Creignou, Nadia, Defrain, Oscar, Olive, Frédéric, and Vilmin, Simon
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Computer Science - Data Structures and Algorithms ,Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
Given a CNF formula $\varphi$ with clauses $C_1, \dots, C_m$ over a set of variables $V$, a truth assignment $\mathbf{a} : V \to \{0, 1\}$ generates a binary sequence $\sigma_\varphi(\mathbf{a})=(C_1(\mathbf{a}), \ldots, C_m(\mathbf{a}))$, called a signature of $\varphi$, where $C_i(\mathbf{a})=1$ if clause $C_i$ evaluates to 1 under assignment $\mathbf{a}$, and $C_i(\mathbf{a})=0$ otherwise. Signatures and their associated generation problems have given rise to new yet promising research questions in algorithmic enumeration. In a recent paper, B\'erczi et al. interestingly proved that generating signatures of a CNF is tractable despite the fact that verifying a solution is hard. They also showed the hardness of finding maximal signatures of an arbitrary CNF due to the intractability of satisfiability in general. Their contribution leaves open the problem of efficiently generating maximal signatures for tractable classes of CNFs, i.e., those for which satisfiability can be solved in polynomial time. Stepping into that direction, we completely characterize the complexity of generating all, minimal, and maximal signatures for XOR-CNFs., Comment: 21 pages, 5 figures
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- 2024
37. Bare mass effects on the reheating process after inflation
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Clery, Simon, Garcia, Marcos A. G., Mambrini, Yann, and Olive, Keith A.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We consider the effects of a bare mass term for the inflaton, when the inflationary potential takes the form $V(\phi)= \lambda \phi^k$ about its minimum with $k \ge 4$. We concentrate on $k=4$, but discuss general cases as well. Further, we assume $\lambda \phi_{\rm end}^2 \gg m_\phi^2$, where $\phi_{\rm end}$ is the inflaton field value when the inflationary expansion ends. We show that the presence of a mass term (which may be present due to radiative corrections or supersymmetry breaking) can significantly alter the reheating process, as the equation of state of the inflaton condensate changes from $w_\phi=\frac{1}{3}$ to $w_\phi=0$ when $\lambda \phi^2$ drops below $m_\phi^2$. We show that for a mass $m_\phi \gtrsim T_{\rm RH}/250$, the mass term will dominate at reheating. We compute the effects on the reheating temperature for cases where reheating is due to inflaton decay (to fermions, scalars, or vectors) or to inflaton scattering (to scalars or vectors). For scattering to scalars and in the absence of a decay, we derive a strong upper limit to the inflaton bare mass $m_\phi < 350~{\rm MeV} (T_{\rm RH}/10^{10}~{\rm GeV})^{3/5}$, as there is always a residual inflaton background which acts as cold dark matter. We also consider the effect of the bare mass term on the fragmentation of the inflaton condensate., Comment: 16 pages, 10 figures
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- 2024
38. Minimal Production of Prompt Gravitational Waves during Reheating
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Choi, Gongjun, Ke, Wenqi, and Olive, Keith A.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The inflationary reheating phase begins when accelerated expansion ends. As all Standard Model particles are coupled to gravity, gravitational interactions will lead to particle production. This includes the thermal bath, dark matter and gravitational radiation. Here, we compute the spectrum of gravitational waves from the inflatoncondensate during the initial phase of reheating. As particular examples of inflation, we consider the Starobinsky model and T-models, all of which are in good phenomenological agreement with CMB anisotropy measurements. The T-models are distinguished by the shape of the potential about its minimum and can be approximated by $V \sim \phi^k$, where $\phi$ is the inflaton. Interestingly, the shape of the gravitational wave spectrum (when observed) can be used to distinguish among the models considered. As we show, the Starobinsky model and T-models with $k=2$, provide very different spectra when compared to models with $k=4$ or $k>4$. Observation of multiple harmonics in the spectrum can be interpreted as a direct measurement of the inflaton mass. Furthermore, the cutoff in frequency can be used to determine the reheating temperature., Comment: 11 pages, 4 figures
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- 2024
39. A brittle constitutive law for long-term tectonic modeling based on sub-critical crack growth
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Petit, Léo, Olive, Jean-Arthur, Schubnel, Alexandre, Pourhiet, Laetitia Le, and Bhat, Harsha S.
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Physics - Geophysics - Abstract
Adequate representations of brittle deformation (fracturing and faulting) are essential ingredients of long term tectonic simulations. Such models commonly rely on Mohr Coulomb plasticity coupled with prescribed softening of cohesion and/or friction with accumulated plastic strain. This approach captures fundamental properties of brittle failure, but is overly sensitive to empirical softening parameters that cannot be determined experimentally. Here we design a brittle constitutive law that captures key processes of brittle deformation, and can be straightforwardly implemented in standard geodynamic models. In our Sub Critically Altered Maxwell (SCAM) flow law, brittle failure begins with the accumulation of distributed brittle damage, which represents the sub critical lengthening of tensile micro cracks prompted by slip on pre existing shear defects. Damage progressively and permanently weakens the rock's elastic moduli, until cracks catastrophically interact and coalesce up to macroscopic failure. The model's micromechanical parameters can be fully calibrated against rock deformation experiments, alleviating the need for ad hoc softening parameters. Upon implementing the SCAM flow law in 2 D plane strain simulations of rock deformation experiments, we find that it can produce Coulomb oriented shear bands which originate as damage bands. SCAM models can also be used to extrapolate rock strength from laboratory to tectonic strain rates, and nuance the use of Byerlee's law as an upper bound on lithosphere stresses. We further show that SCAM models can be upscaled to simulate tectonic deformation of a 10 km thick brittle plate over millions of years. These features make the SCAM rheology a promising tool to further investigate the complexity of brittle behavior across scales.
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- 2024
40. From Politics to Transformative Politics of Nature in Canada (book excerpt)
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Beazley, Karen F., Olive, Andrea, and Finegan, Chance
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An excerpt from the opening chapter Transformative Politics of Nature: Overcoming Barriers to Conservation in Canada, edited by Andrea Olive, Chance Finegan, and Karen F. Beazley (University of Toronto Press, 2023).
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- 2024
41. Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab.
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Chandrakasan, Shanmuganathan, Jordan, Michael, Baker, Ashley, Behrens, Edward, Bhatla, Deepika, Chien, May, Eckstein, Olive, Henry, Michael, Hermiston, Michelle, Hinson, Ashley, Leiding, Jennifer, Oladapo, Abiola, Patel, Sachit, Pednekar, Priti, Ray, Anish, Dávila Saldaña, Blachy, Sarangi, Susmita, Walkovich, Kelly, Yee, John, Zoref-Lorenz, Adi, and Allen, Carl
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Humans ,Lymphohistiocytosis ,Hemophagocytic ,Female ,Male ,Treatment Outcome ,Adolescent ,Child ,Retrospective Studies ,Child ,Preschool ,Infant ,Young Adult ,Antibodies ,Monoclonal ,Adult - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening, hyperinflammatory syndrome. Emapalumab, a fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon gamma, is approved in the United States to treat primary HLH (pHLH) in patients with refractory, recurrent, or progressive disease, or intolerance with conventional HLH treatments. REAL-HLH, a retrospective study, conducted across 33 US hospitals, evaluated real-world treatment patterns and outcomes in patients treated with ≥1 dose of emapalumab between 20 November 2018 and 31 October 2021. In total, 46 patients met the pHLH classification criteria. Median age at diagnosis was 1.0 year (range, 0.3-21.0). Emapalumab was initiated for treating refractory (19/46), recurrent (14/46), or progressive (7/46) pHLH. At initiation, 15 of 46 patients were in the intensive care unit, and 35 of 46 had received prior HLH-related therapies. Emapalumab treatment resulted in normalization of key laboratory parameters, including chemokine ligand 9 (24/33, 72.7%), ferritin (20/45, 44.4%), fibrinogen (37/38, 97.4%), platelets (39/46, 84.8%), and absolute neutrophil count (40/45, 88.9%). Forty-two (91.3%) patients were considered eligible for transplant. Pretransplant survival was 38 of 42 (90.5%). Thirty-one (73.8%) transplant-eligible patients proceeded to transplant, and 23 of 31 (74.2%) of those who received transplant were alive at the end of the follow-up period. Twelve-month survival probability from emapalumab initiation for the entire cohort (N = 46) was 73.1%. There were no discontinuations because of adverse events. In conclusion, results from the REAL-HLH study, which describes treatment patterns, effectiveness, and outcomes in patients with pHLH treated with emapalumab in real-world settings, are consistent with the emapalumab pivotal phase 2/3 pHLH trial.
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- 2024
42. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17
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Cavagnero, Kellen J, Li, Fengwu, Dokoshi, Tatsuya, Nakatsuji, Teruaki, O’Neill, Alan M, Aguilera, Carlos, Liu, Edward, Shia, Michael, Osuoji, Olive, Hata, Tissa, and Gallo, Richard L
- Subjects
Biomedical and Clinical Sciences ,Infectious Diseases ,Inflammatory and immune system ,Mice ,Animals ,Humans ,Interleukin-17 ,Neutrophil Infiltration ,Staphylococcus aureus ,Skin ,Fibroblasts ,Chemokine CXCL12 ,Medical and Health Sciences ,Immunology ,Biomedical and clinical sciences ,Health sciences - Abstract
The skin provides an essential barrier for host defense through rapid action of multiple resident and recruited cell types, but the complex communication network governing these processes is incompletely understood. To define these cell-cell interactions more clearly, we performed an unbiased network analysis of mouse skin during invasive S. aureus infection and revealed a dominant role for CXCL12+ fibroblast subsets in neutrophil communication. These subsets predominantly reside in the reticular dermis, express adipocyte lineage markers, detect IL-17 and TNFα, and promote robust neutrophil recruitment through NFKBIZ-dependent release of CXCR2 ligands and CXCL12. Targeted deletion of Il17ra in mouse fibroblasts resulted in greatly reduced neutrophil recruitment and increased infection by S. aureus. Analogous human CXCL12+ fibroblast subsets abundantly express neutrophil chemotactic factors in psoriatic skin that are subsequently decreased upon therapeutic targeting of IL-17. These findings show that CXCL12+ dermal immune acting fibroblast subsets play a critical role in cutaneous neutrophil recruitment and host defense.
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- 2024
43. Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimers disease.
- Author
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Martinelli, Filippo, Heinken, Almut, Henning, Ann-Kristin, Ulmer, Maria, Hensen, Tim, González, Antonio, Arnold, Matthias, Asthana, Sanjay, Budde, Kathrin, Engelman, Corinne, Estaki, Mehrbod, Grabe, Hans-Jörgen, Heston, Margo, Johnson, Sterling, Kastenmüller, Gabi, Martino, Cameron, McDonald, Daniel, Rey, Federico, Kilimann, Ingo, Peters, Olive, Wang, Xiao, Spruth, Eike, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Hansen, Niels, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Laske, Christoph, Munk, Matthias, Spottke, Annika, Roy, Nina, Nauck, Matthias, Teipel, Stefan, Kaddurah-Daouk, Rima, Bendlin, Barbara, Hertel, Johannes, Thiele, Ines, and Knight, Rob
- Subjects
Alzheimer’s disease ,Co-metabolism ,Constraint-based modelling ,Formate ,Host-microbiome ,Metabolic modelling ,Metabolomics ,Microbiome ,Pathways ,Humans ,Alzheimer Disease ,Microbiota ,Gastrointestinal Microbiome ,Genomics ,Formates - Abstract
In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimers disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individuals with AD and controls, revealing decreased formate and fumarate concentrations in AD. Additionally, we utilised whole-genome sequencing (WGS) data obtained from a separate group of individuals with AD and controls. This information allowed us to create and investigate host-microbiome personalised whole-body metabolic models. Notably, AD individuals displayed diminished formate microbial secretion in these models. Additionally, we identified specific reactions responsible for the production of formate in the host, and interestingly, these reactions were linked to genes that have correlations with AD. This study suggests formate as a possible early AD marker and highlights genetic and microbiome contributions to its production. The reduced formate secretion and its genetic associations point to a complex connection between gut microbiota and AD. This holistic understanding might pave the way for novel diagnostic and therapeutic avenues in AD management.
- Published
- 2024
44. Knowledge of hand hygiene and evaluation of hand washing technique among nurses at the University of Nigeria Teaching Hospital
- Author
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Nwosu, Nnamdi Ikechukwu, Mmerem, Juliet Ijeoma, Ozougwu, Jideofor Jacob, Nlewedim, Paul Ikechukwu, Ugwa, Onyekachi Michael, Ugwunna, Nwachukwu Chinedu, Nwosu, Ezinne Olive, and Ndu, Anne Chigedu
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- 2024
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45. Research utilization competency development in the health workforce pipeline: Design and formative evaluation of learning objectives for health professions students
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Yini Karway, Olive W., Wleh, Jeremiah, Kpatakolee, Yamah, Sieka, Joseph, Candy, Neima, Talbert-Slagle, Kristina, Dahn, Bernice T., Harmon-Gray, Wahdae-Mai, and Skrip, Laura A.
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- 2024
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46. Towards sustainable construction in Cameroon : impact of tropical plant fibers on the performance of compressed earth bricks
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Ebanda, Fabien Betene, Mewoli, Armel Edwige, Njom, Abel Emmanuel, Kibong, Marius Tony, Anicet Noah, Pierre Marcel, Ndiwé, Benoit, Ndengue, Marie Josette, Biloa Otiti, Sandrine Olive, Lucien Meva’a, Jean Raymond, and Ateba, Atangana
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- 2024
- Full Text
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47. Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease
- Author
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Martinelli, Filippo, Heinken, Almut, Henning, Ann-Kristin, Ulmer, Maria A., Hensen, Tim, González, Antonio, Arnold, Matthias, Asthana, Sanjay, Budde, Kathrin, Engelman, Corinne D., Estaki, Mehrbod, Grabe, Hans-Jörgen, Heston, Margo B., Johnson, Sterling, Kastenmüller, Gabi, Martino, Cameron, McDonald, Daniel, Rey, Federico E., Kilimann, Ingo, Peters, Olive, Wang, Xiao, Spruth, Eike Jakob, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Hansen, Niels, WenzelGlanz, Buerger, Katharina, Janowitz, Daniel, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Nauck, Matthias, Teipel, Stefan, Knight, Rob, Kaddurah-Daouk, Rima F., Bendlin, Barbara B., Hertel, Johannes, and Thiele, Ines
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- 2024
- Full Text
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48. Factors associated with perceived health of school-aged children in rural Rwanda: an opportunity to leverage community health workers to enhance school health promotion and primary healthcare systems linkages
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Manzi, Anatole, Nguyen, Daniel, Katz, Benjamin, Michel, Clara Agyapomaa, Nilingiyimana, Theophile, Sendarasi, Titien, Niyonzima, Joseph, Nyiraneza, Olive, Bimenyimana, Norbert Blaise, and Bloom, Elizabeth
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- 2024
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49. An Overview of Film-Forming Emulsions for Dermal and Transdermal Drug Delivery
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Morales-Becerril, Aideé, Aranda-Lara, Liliana, Isaac-Olive, Keila, Ramírez-Villalva, Alejandra, Ocampo-García, Blanca, and Morales-Avila, Enrique
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- 2024
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50. Factors influencing abortion care-seeking outside of formal healthcare settings: lived experiences from Rwandan young women
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Ndayisenga, Jean Pierre, Yamuragiye, Assumpta, Oudshoorn, Abe, Katende, Godfrey, Nkurunziza, Aimable, Tengera, Olive, Hitayezu, Jean Bosco Henri, Bagirisano, Justine, Ayinkamiye, Jeanne d’ Arc, and Uwitonze, Gilbert
- Published
- 2024
- Full Text
- View/download PDF
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