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The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) is a proposed dual-satellite mission to observe Ultra-High-Energy Cosmic Rays (UHECRs), increasing the statistics at the highest energies, and Very-High-Energy Neutrinos (VHENs), following multi-messenger alerts of astrophysical transient events throughout the universe such as gamma-ray bursts and gravitational wave events. POEMMA-Balloon with Radio (PBR) is a scaled-down version of the POEMMA design, adapted to be flown as a payload on one of NASA's sub-orbital Super Pressure Balloons (SPBs) circling over the Southern Ocean for up to 100 days after a launch from Wanaka, New Zealand. This overview will provide a summary of the mission with its science goals, the instruments, and the current status of PBR.

The POEMMA-Balloon with Radio (PBR) is a proposed payload to fly on a NASA Super Pressure Balloon (SPB). It will act as a pathfinder of the Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) detector. PBR will consist of an innovative hybrid focal surface featuring a Fluorescence Camera (FC, based on Multi-Anode Photomultiplier Tubes [MAPMTs], 1.05 $\mu$s time resolution) and a Cherenkov Camera (based on SiPMs, 10 ns time resolution), both mounted on the same tiltable frame that can point from nadir up to 13$^\circ$ above the horizon. The FC's main scientific goal is to observe, for the first time, the fluorescence emission of Extensive Air Showers produced by Ultra-High Energy Cosmic Rays from sub-orbital altitudes. This measurement will validate the detection strategy for future space-based missions, such as POEMMA. As a secondary goal, the FC will perform a search for macroscopic dark matter through slowly evolving showers that will leave a signal similar to (but distinct from) a meteor. PBR targets a launch in 2027 as a payload of an ultra-long duration balloon flight with a duration of up to 100 days.

Chronic wounds pose an ongoing health concern globally, largely due to the prevalence of conditions such as diabetes and leprosy's disease. The standard method of monitoring these wounds involves visual inspection by healthcare professionals, a practice that could present challenges for patients in remote areas with inadequate transportation and healthcare infrastructure. This has led to the development of algorithms designed for the analysis and follow-up of wound images, which perform image-processing tasks such as classification, detection, and segmentation. However, the effectiveness of these algorithms heavily depends on the availability of comprehensive and varied wound image data, which is usually scarce. This paper introduces the CO2Wounds-V2 dataset, an extended collection of RGB wound images from leprosy patients with their corresponding semantic segmentation annotations, aiming to enhance the development and testing of image-processing algorithms in the medical field., Comment: 2024 IEEE International Conference on Image Processing (ICIP 2024)

The Extreme Universe Space Observatory on a Super Pressure Balloon 2 (EUSO-SPB2) flew on May 13$^{\text{th}}$ and 14$^{\text{th}}$ of 2023. Consisting of two novel optical telescopes, the payload utilized next-generation instrumentation for the observations of extensive air showers from near space. One instrument, the fluorescence telescope (FT) searched for Ultra-High Energy Cosmic Rays (UHECRs) by recording the atmosphere below the balloon in the near-UV with a 1~$\mu$s time resolution using 108 multi-anode photomultiplier tubes with a total of 6,912 channels. Validated by pre-flight measurements during a field campaign, the energy threshold was estimated around 2~EeV with an expected event rate of approximately 1 event per 10 hours of observation. Based on the limited time afloat, the expected number of UHECR observations throughout the flight is between 0 and 2. Consistent with this expectation, no UHECR candidate events have been found. The majority of events appear to be detector artifacts that were not rejected properly due to a shortened commissioning phase. Despite the earlier-than-expected termination of the flight, data were recorded which provide insights into the detectors stability in the near-space environment as well as the diffuse ultraviolet emissivity of the atmosphere, both of which are impactful to future experiments.

The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33~km). After 12~days and 4~hours aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of approximately 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search., Comment: 18 pages, 19 figures

This is a collection of papers presented by the JEM-EUSO Collaboration at the 38th International Cosmic Ray Conference (Nagoya, Japan, July 26-August 3, 2023)

JEM--EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAFin the framework of the JEM--EUSO program and explain the physical assumptions used. We present here the implementation of the JEM--EUSO, POEMMA, K--EUSO, TUS, Mini--EUSO, EUSO--SPB1 and EUSO--TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.

The second generation of the Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB2) is a balloon instrument that searched for ultra high energy cosmic rays (UHECRs) with energies above 1 EeV and very high energy neutrinos with energies above 1 PeV. EUSO-SPB2 consists of two telescopes: a fluorescence telescope pointed downward for the detection of UHECRs and a Cherenkov telescope toward the limb for the detection of PeV-scale showers produced by neutrino-sourced tau decay (just below the limb) and by cosmic rays (just above the limb). Clouds inside the fields of view of these telescopes--particularly that of the fluorescence telescope--reduce EUSO-SPB2's geometric aperture. As such, cloud coverage and cloud-top altitude within the field of view of the fluorescence telescope must be monitored throughout data-taking. The University of Chicago Infrared Camera (UCIRC2) monitored these clouds using two infrared cameras centered at 10 and 12 $\mu$m. By capturing images at wavelengths spanning the cloud thermal emission peak, UCIRC2 measured cloud color-temperatures and thus cloud-top altitudes. In this contribution, we provide an overview of UCIRC2, including an update on its construction and performance. We also show first results from the flight., Comment: 10 pages, 7 figures, proceedings of the 38th International Cosmic Ray Conference (ICRC 2023). arXiv admin note: substantial text overlap with arXiv:2112.09618, arXiv:1909.02663

Mini-EUSO is a wide Field-of-View (FoV, 44$^{\circ}$) telescope currently in operation from a nadia-facing UV-transparent window in the Russian Zvezda module on the International Space Station (ISS). It is the first detector of the JEM-EUSO program deployed on the ISS, launched in August 2019. The main goal of Mini-EUSO is to measure the UV emissions from the ground and atmosphere, using an orbital platform. Mini-EUSO is mainly sensitive in the 290-430 nm bandwidth. Light is focused by a system of two Fresnel lenses of 25 cm diameter each on the Photo- Detector-Module (PDM), which consists of an array of 36 Multi-Anode Photomultiplier Tubes (MAPMTs), for a total of 2304 pixels working in photon counting mode, in three different time resolutions of 2.5 ${\mu}$s, 320 ${\mu}$s, 40.96 ms operation in parallel. In the longest time scale, the data is continuously acquired to monitor the UV emission of the Earth. It is best suited for the observation of ground sources and therefore has been used for the observational campaigns of the Mini-EUSO. In this contribution, we present the assembled UV flasher, the operation of the field campaign and the analysis of the obtained data. The result is compared with the overall efficiency computed from the expectations which takes into account the atmospheric attenuation and the parameterization of different effects such as the optics efficiency, the MAPMT detection efficiency, BG3 filter transmittance and the transparency of the ISS window.

The Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) was designed as a NASA Astrophysics probe-class mission to identify the sources of ultrahigh energy cosmic rays (UHECRs) and observe cosmic neutrinos from extremely energetic transient sources. POEMMA consists of two identical spacecraft flying in a loose formation at 525 km altitude oriented to view a common atmospheric volume and to provide full-sky coverage for both types of messengers. Each spacecraft hosts a wide field of view Schmidt telescope with a hybrid focal plane optimized to observe both the UV fluorescence signal from extensive air showers (EASs) and the optical Cherenkov signals from EASs. When in stereo close to nadir mode, POEMMA can measure the spectrum, composition, and full-sky distribution of the UHECRs above 20 EeV and be sensitive to UHE neutrinos. When pointing just below the Earth's limb, POEMMA will be sensitive to cosmic tau neutrinos above 20 PeV by observing the Cherenkov radiation of EASs produced by upward-moving tau decays, induced from tau neutrino interactions in the Earth. POEMMA is designed to quickly re-orient to follow a Target-of-Opportunity (ToO) neutrino transient from astrophysical sources with exceptional sensitivity to neutrinos from both short-duration transients, such as short-gamma-ray bursts (sGRBs), and long-duration sources, such as binary neutron star (BNS) mergers. Here we review the POEMMA mission and discuss the recent progress towards its technical readiness provided by the Mini-EUSO and EUSO-SPB2 missions and the forthcoming Terzina and POEMMA-Balloon-Radio missions, Comment: 12 pages, 5 figures, Proceeding 38th ICRC 2023 Nagoya, Japan. arXiv admin note: substantial text overlap with arXiv:1909.09466

Observing ultra-high energy cosmic rays (UHECR) and very high energy (VHE) neutrinos from space is a promising way to measure their extremely low fluxes by significantly increasing the observed volume. The Extreme Universe Space Observatory on a Super Pressure Balloon 2 (EUSO-SPB2), the next, most advanced pathfinder for such a mission, was launched May 13th 2023 from Wanaka New Zealand. The pioneering EUSO-SPB2 payload flew a Fluorescence Telescope (FT) with a PMT camera pointed in nadir to record fluorescence light from cosmic ray extensive air shower (EAS) with energies above 1 EeV, and a Cherenkov telescope (CT) with a silicon photomultiplier focal surface for observing Cherenkov emission of cosmic ray EAS with energies above 1 PeV with an above-the-limb geometry and of PeV-scale EAS initiated by neutrino-sourced tau decay. As the CT is a novel instrument, optical background measurements for space neutrino observation are an important goal of the mission. Any data collected during the mission will influence and improve the development of a space-based multi-messenger observatory such as the Probe of Extreme Multi-Messenger Astrophysics (POEMMA). We present an overview of the EUSO-SPB2 mission and its science goals and summarize results as available, from the 2023 flight., Comment: Proceeding 38th ICRC 2023 Nagoya, Japan

Using the Earth as a neutrino converter, tau neutrino fluxes from astrophysical point sources can be detected by tau-lepton-induced extensive air showers (EASs). Both muon neutrino and tau neutrino induced upward-going EAS signals can be detected by terrestrial, sub-orbital and satellite-based instruments. The sensitivity of these neutrino telescopes can be evaluated with the nuSpaceSim package, which includes the nuPyProp simulation package. The nuPyProp package propagates neutrinos ($\nu_\mu$, $\nu_\tau$) through the Earth to produce the corresponding charged leptons (muons and tau-leptons). We use nuPyProp to quantify the uncertainties from Earth density models, tau depolarization effects and photo-nuclear electromagnetic energy loss models in the charged lepton exit probabilities and their spectra. The largest uncertainties come from electromagnetic energy loss modeling, with as much as a 20-50% difference between the models. We compare nuPyProp results with other simulation package results., Comment: 9 pages, 6 figures, Proceedings for International Cosmic Ray Conference (ICRC) 2023

About ten years ago, a paper proposed the first integer linear programming formulation for the constrained two-dimensional guillotine cutting problem (with unlimited cutting stages). Since, six other formulations followed, five of them in the last two years. This spike of interest gave no opportunity for a comprehensive comparison between the formulations. We review each formulation and compare their empirical results over instance datasets of the literature. We adapt most formulations to allow for piece rotation. The possibility of adaptation was already predicted but not realized by the prior work. The results show the dominance of pseudo-polynomial formulations until the point instances become intractable by them, while more compact formulations keep achieving good primal solutions. Our study also reveals a small but consistent advantage of the Gurobi solver over the CPLEX solver in our context; that the choice of solver hardly benefits one formulation over another; and a mistake in the generation of the T instances, which should have the same optima with or without guillotine cuts. Our study also proposes hybridising the most recent formulation with a prior formulation for a restricted version of the problem. The hybridisations show a reduction of about 20% of the branch-and-bound time thanks to the symmetries broken by the hybridisation., Comment: 23 pages, 7 tables, 3 figures

Mini-EUSO (Multiwavelength Imaging New Instrument for the Extreme Universe Space Observatory) is a telescope observing the Earth from the International Space Station since 2019. The instrument employs a Fresnel-lens optical system and a focal surface composed of 36 multi-anode photomultiplier tubes, 64 channels each, for a total of 2304 channels with single photon counting sensitivity. Mini-EUSO also contains two ancillary cameras to complement measurements in the near infrared and visible ranges. The scientific objectives of the mission range from the search for extensive air showers generated by Ultra-High Energy Cosmic Rays (UHECRs) with energies above 10$^{21}$ eV, the search for nuclearites and Strange Quark Matter (SQM), up to the study of atmospheric phenomena such as Transient Luminous Events (TLEs), meteors and meteoroids. Mini-EUSO can map the night-time Earth in the near UV range (between 290-430 nm) with a spatial resolution of about 6.3 km (full field of view of 44{\deg}) and a maximum temporal resolution of 2.5 $\mu$s, observing our planet through a nadir-facing UV-transparent window in the Russian Zvezda module. The detector saves triggered transient phenomena with a sampling rate of 2.5 $\mu$s and 320 $\mu$s, as well as continuous acquisition at 40.96 ms scale. In this paper we discuss the detector response and the flat-fielding and calibration procedures. Using the 40.96 ms data, we present $\simeq$6.3 km resolution night-time Earth maps in the UV band, and report on various emissions of anthropogenic and natural origin. We measure ionospheric airglow emissions of dark moonless nights over the sea and ground, studying the effect of clouds, moonlight, and artificial (towns, boats) lights. In addition to paving the way forward for the study of long-term variations of natural and artificial light, we also estimate the observation live-time of future UHECR detectors., Comment: 49 pages, 27 figures, 1 table, published in Remote Sensing of Environment

Ultra-high-energy neutrinos serve as messengers of some of the highest energy astrophysical environments. Given that neutrinos are neutral and only interact via weak interactions, neutrinos can emerge from sources, traverse astronomical distances, and point back to their origins. Their weak interactions require large target volumes for neutrino detection. Using the Earth as a neutrino converter, terrestrial, sub-orbital, and satellite-based instruments are able to detect signals of neutrino-induced extensive air showers. In this paper, we describe the software code $\texttt{nuPyProp}$ that simulates tau neutrino and muon neutrino interactions in the Earth and predicts the spectrum of the $\tau$-lepton and muons that emerge. The $\texttt{nuPyProp}$ outputs are lookup tables of charged lepton exit probabilities and energies that can be used directly or as inputs to the $\texttt{nuSpaceSim}$ code designed to simulate optical and radio signals from extensive air showers induced by the emerging charged leptons. We describe the inputs to the code, demonstrate its flexibility and show selected results for $\tau$-lepton and muon exit probabilities and energy distributions. The $\texttt{nuPyProp}$ code is open source, available on Github., Comment: 42 pages, 21 figures, fixed typo in one of the author's name. Code available at https://github.com/NuSpaceSim/nupyprop

Cosmic Probes of Fundamental Physics take two primary forms: Very high energy particles (cosmic rays, neutrinos, and gamma rays) and gravitational waves. Already today, these probes give access to fundamental physics not available by any other means, helping elucidate the underlying theory that completes the Standard Model. The last decade has witnessed a revolution of exciting discoveries such as the detection of high-energy neutrinos and gravitational waves. The scope for major developments in the next decades is dramatic, as we detail in this report., Comment: Report of theTopical Group on Cosmic Probes of Fundamental Physics, for the U.S. decadal Particle Physics Planning Exercise (Snowmass 2021)

The next generation of ultra-high energy cosmic ray (UHECR) and very-high energy neutrino observatories will address the challenge of the extremely low fluxes of these particles at the highest energies. EUSO-SPB2 (Extreme Universe Space Observatory on a Super Pressure Balloon2) is designed to prepare space missions to address this challenge. EUSO-SPB2 is equipped with 2 telescopes: the Fluorescence Telescope, which will point downwards and measure fluorescence emission from UHECR air showers with an energy above 2EeV, and the Cherenkov Telescope (CT), which will point towards the Earth's limb and measure direct Cherenkov emission from cosmic rays with energies above 1PeV, verifying the technique. Pointed below the limb, the CT will search for Cherenkov emission produced by neutrino-sourced tau-lepton decays above 10PeV energies and study backgrounds for such events. The EUSO-SPB2 mission will provide pioneering observations and technical milestones on the path towards a space-based multi-messenger observatory., Comment: Submission to SciPost Phys. Proc

Home health care problems consist of scheduling visits to home patients by health professionals while following a series of requirements. This paper studies the Home Health Care Routing and Scheduling Problem, which comprises a multi-attribute vehicle routing problem with soft time windows. Additional route inter-dependency constraints apply for patients requesting multiple visits, either by simultaneous visits or visits with precedence. We apply a mathematical programming solver to obtain lower bounds for the problem. We also propose a biased random-key genetic algorithm, and we study the effects of additional state-of-art components recently proposed in the literature for this genetic algorithm. We perform computational experiment using a publicly available benchmark dataset. Regarding the previous local search-based methods, we find results up to 26.1% better than those of the literature. We find improvements from around 0.4% to 6.36% compared to previous results from a similar genetic algorithm., Comment: 32 pages, 5 figures, submitted to International Transactions in Operational Research

The present white paper is submitted as part of the "Snowmass" process to help inform the long-term plans of the United States Department of Energy and the National Science Foundation for high-energy physics. It summarizes the science questions driving the Ultra-High-Energy Cosmic-Ray (UHECR) community and provides recommendations on the strategy to answer them in the next two decades., Comment: Prepared as a solicited white paper for the 2021 Snowmass process. To be published in the Journal of High Energy Astrophysics. v2: fixed typos in author list. v3: included all community feedback received by July 1st 2022 and added the list of endorsers. v4 is the post-reviewer preprint accepted to Astroparticle Physics vol. 149

Compilation of papers presented by the JEM-EUSO Collaboration at the 37th International Cosmic Ray Conference (ICRC), held on July 12-23, 2021 (online) in Berlin, Germany., Comment: html page with links to the JEM-EUSO Collaboration papers presented at ICRC-2021, Berlin, Germany

The Fluorescence Telescope is one of the two telescopes on board the Extreme Universe Space Observatory on a Super Pressure Balloon II (EUSO-SPB2). EUSO-SPB2 is an ultra-long-duration balloon mission that aims at the detection of Ultra High Energy Cosmic Rays (UHECR) via the fluorescence technique (using a Fluorescence Telescope) and of Ultra High Energy (UHE) neutrinos via Cherenkov emission (using a Cherenkov Telescope). The mission is planned to fly in 2023 and is a precursor of the Probe of Extreme Multi-Messenger Astrophysics (POEMMA). The Fluorescence Telescope is a second generation instrument preceded by the telescopes flown on the EUSO-Balloon and EUSO-SPB1 missions. It features Schmidt optics and has a 1-meter diameter aperture. The focal surface of the telescope is equipped with a 6912-pixel Multi Anode Photo Multipliers (MAPMT) camera covering a 37.4 x 11.4 degree Field of Regard. Such a big Field of Regard, together with a flight target duration of up to 100 days, would allow, for the first time from suborbital altitudes, detection of UHECR fluorescence tracks. This contribution will provide an overview of the instrument including the current status of the telescope development., Comment: ICRC 2021

The second generation of the Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB2) is a balloon instrument for the detection of ultra high energy cosmic rays (UHECRs) with energies above 1 EeV and very high energy neutrinos with energies above 10 PeV. EUSO-SPB2 consists of two telescopes: a fluorescence telescope pointed downward for the detection of UHECRs and a Cherenkov telescope pointed towards the limb for the detection of tau lepton-induced showers produced by up-going tau neutrinos and background signals below the limb. Clouds inside the field of view of these telescopes reduce EUSO-SPB2's geometric aperture, in particular that of the fluorescence telescope. For this reason, cloud coverage and cloud-top altitude within the field of view of the fluorescence telescope must be monitored throughout data-taking. The University of Chicago Infrared Camera (UCIRC2) will monitor these clouds using two infrared cameras with response centered at wavelengths 10 and 12 microns. By capturing images at wavelengths spanning the cloud thermal emission peak, UCIRC2 will measure cloud color-temperatures and thus cloud-top altitudes. In this contribution, we provide an overview of UCIRC2, including an update on its construction and a discussion of the techniques used to calibrate the instrument., Comment: 12 pages, 5 figures, proceedings of the 37th International Cosmic Ray Conference (ICRC 2021). arXiv admin note: substantial text overlap with arXiv:1909.02663

The Extreme Universe Space Observatory - Super Pressure Balloon (EUSO-SPB2) mission will fly two custom telescopes that feature Schmidt optics to measure \v{C}erenkov- and fluorescence-emission of extensive air-showers from cosmic rays at the PeV and EeV-scale, and search for tau-neutrinos. Both telescopes have 1-meter diameter apertures and UV/UV-visible sensitivity. The \v{C}erenkov telescope uses a bifocal mirror segment alignment, to distinguish between a direct cosmic ray that hits the camera versus the \v{C}erenkov light from outside the telescope. Telescope integration and laboratory calibration will be performed in Colorado. To estimate the point spread function and efficiency of the integrated telescopes, a test beam system that delivers a 1-meter diameter parallel beam of light is being fabricated. End-to-end tests of the fully integrated instruments will be carried out in a field campaign at dark sites in the Utah desert using cosmic rays, stars, and artificial light sources. Laser tracks have long been used to characterize the performance of fluorescence detectors in the field. For EUSO-SPB2 an improvement in the method that includes a correction for aerosol attenuation is anticipated by using a bi-dynamic Lidar configuration in which both the laser and the telescope are steerable. We plan to conduct these field tests in Fall 2021 and Spring 2022 to accommodate the scheduled launch of EUSO-SPB2 in 2023 from Wanaka, New Zealand.